{"id":1862,"date":"2021-02-07T22:14:43","date_gmt":"2021-02-07T14:14:43","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2021\/02\/07\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac6%e7%ab%a0%ef%bc%9a%e6%8a%97%e4%bd%93%e5%a4%9a%e6%a0%b7%e6%80%a7\/"},"modified":"2021-02-07T22:14:43","modified_gmt":"2021-02-07T14:14:43","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac6%e7%ab%a0%ef%bc%9a%e6%8a%97%e4%bd%93%e5%a4%9a%e6%a0%b7%e6%80%a7","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2021\/02\/07\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac6%e7%ab%a0%ef%bc%9a%e6%8a%97%e4%bd%93%e5%a4%9a%e6%a0%b7%e6%80%a7\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027"},"content":{"rendered":"
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\u4eba\u4f53\u4f3c\u4e4e\u80fd\u591f\u4ea7\u751f\u65e0\u9650\u91cf\u7684\u6297\u4f53(\u514d\u75ab\u7403\u86cb\u767d[Ig])\u5206\u5b50-\u4e5f\u8bb8\u5b87\u5b99\u4e2d\u7684\u6bcf\u4e2a\u6297\u539f\u81f3\u5c11\u6709\u4e00\u4e2a\uff01\u8ba1\u7b97\u8868\u660e\uff0c\u4eba\u7c7b\u6297\u4f53\u5e93\u4e2d\u53ef\u80fd\u6709\u591a\u8fbe1011<\/sup>\u79cd\u4e0d\u540c\u7684\u6297\u4f53\u5206\u5b50\u53ef\u7528\uff0c\u8fd9\u4e9b\u6297\u4f53\u5177\u6709\u4e0d\u540c\u7279\u5f02\u6027\u3002\u672c\u7ae0\u63cf\u8ff0\u4e86B\u7ec6\u80de\u4e2d\u4ea7\u751f\u6297\u4f53\u591a\u6837\u6027\u7684\u5404\u79cd\u673a\u5236\u3002\u5728T\u7ec6\u80de\u4e2d\u4e5f\u5b58\u5728\u7c7b\u4f3c\u7684\u673a\u5236\u4ea7\u751fT\u7ec6\u80de\u53d7\u4f53(TCR)\u591a\u6837\u6027\uff0c\u4f46\u8fc4\u4eca\u4e3a\u6b62\u5c1a\u672a\u5728\u5176\u4ed6\u57fa\u56e0\u4e2d\u68c0\u6d4b\u5230\u8fd9\u4e9b\u673a\u5236\u3002\u8fd9\u4e9b\u4e0d\u540c\u673a\u5236\u7edf\u79f0\u4e3a\u591a\u6837\u6027\u7684\u4ea7\u751f\u3002\u4e0a\u56fe\u6982\u8ff0\u4e86\u7ec4\u88c5\u5b8c\u6574\u514d\u75ab\u7403\u86cb\u767d\u5206\u5b50\uff08Ig\uff09\u7684\u5404\u4e2a\u6b65\u9aa4\uff0c\u672c\u7ae0\u63cf\u8ff0\u5728B\u7ec6\u80de\u4e2d\u7ec4\u88c5Ig\u7684\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u7b2c\u56db\u7ae0\u6240\u8ff0\uff0cIg\u6709\u4e24\u79cd\u591a\u80bd\u94fe\uff0c\u91cd\u94fe\u548c\u8f7b\u94fe\u3002\u6bcf\u4e2a\u94fe\u90fd\u6709\u4e00\u4e2a\u53d8\u91cf(V)\u548c\u5e38\u6570(C)\u533a\u57df\u3002Ig\u591a\u80bd\u94fe\u7531\u57fa\u56e0\u7247\u6bb5\u7f16\u7801(Fig. 6.1<\/span>)\uff0c\u8fd9\u4e9b\u57fa\u56e0\u7247\u6bb5\u5728B\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u88ab\u91cd\u65b0\u6392\u5217(Fig. 6.2<\/span>) \uff0c\u4ece\u800c\u7ec4\u88c5\u6210\u7f16\u7801\u8f7b\u94fe\u6216\u91cd\u94fe\u7684\u529f\u80fd\u57fa\u56e0 (Fig. 6.3<\/span>)\u3002\u8fd9\u4e9b\u57fa\u56e0\u7247\u6bb5\u9664\u4e86V\u548cC\u57fa\u56e0\u7247\u6bb5\u5916\uff0c\u8fd8\u5305\u62ec\u524d\u5bfc\u57fa\u56e0\u7247\u6bb5(Leader\uff0cL)\u3001\u8fde\u63a5\u57fa\u56e0\u7247\u6bb5(Joining\uff0cJ)\u548c\u591a\u6837\u6027\u57fa\u56e0\u7247\u6bb5(Diversity\uff0cD)\u3002\u57fa\u56e0\u7247\u6bb5\u4ee5\u96c6\u5408\u6216\u7ec4\u7684\u5f62\u5f0f\u5b58\u5728\uff0c\u8fd9\u4e9b\u96c6\u5408\u6216\u7ec4\u662f\u7531\u57fa\u56e0\u7247\u6bb5\u4e0d\u540c\u7248\u672c\u7684\u5e8f\u5217\u6784\u6210\u3002\u4f8b\u5982\uff0c\u4e94\u4e2a\u4e0d\u540c\u7684 Jk\u57fa\u56e0\u7247\u6bb5\u6784\u6210\u4e86 Jk\u96c6\u5408\u3002Fig6.1<\/span>\u5c55\u793a\u4e86\u4eba\u8f7b\u94fe\u548c\u91cd\u94fe\u57fa\u56e0\u7247\u6bb5\u7684\u7ed3\u6784\uff0c\u5e76\u5217\u4e3e\u4e86Igs\u7684\u4e0d\u540c\u57fa\u56e0\u7247\u6bb5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728B\u7ec6\u80de\u7684\u53d1\u80b2\u8fc7\u7a0b\u4e2d(\u7b2c14\u7ae0<\/span>)\uff0cIg\u57fa\u56e0\u7247\u6bb5\u88ab\u91cd\u65b0\u6392\u5217\u5f7c\u6b64\u76f8\u8fde\u5f62\u6210\u5177\u6709\u8fde\u7eed\u6027\u7684\u529f\u80fd\u57fa\u56e0(\u89c1Fig6.3<\/span>)\u3002\u91cd\u6392\u7684\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u4f53\u7ec6\u80de\u91cd\u7ec4\uff0c\u5373\u4f7f\u6ca1\u6709\u6297\u539f\u4e5f\u4f1a\u53d1\u751f\uff0c\u4ece\u800c\u4ea7\u751f\u6f5c\u5728\u7684\u6297\u4f53(\u6297\u539f\u53d7\u4f53)\u5206\u5b50<\/span>\u3002\u4e00\u65e6\u5b8c\u6210\u8f7b\u94fe\u548c\u91cd\u94fe\u57fa\u56e0\u7684\u7ec4\u88c5\uff0c\u5c31\u80fd\u591f\u5408\u6210Ig\u8f7b\u94fe\u548c\u91cd\u94fe\uff0c\u5e76\u5c06\u591a\u80bd\u94fe\u7ec4\u88c5\u6210Ig\u5206\u5b50\u3002\u8fd9\u79cd\u5206\u5b50\u8981\u4e48\u5728B\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff0c\u8981\u4e48\u7531\u79f0\u4e3a\u6d46\u7ec6\u80de\u7684\u5206\u5316B\u7ec6\u80de\u5206\u6ccc(\u89c1Fig6.6<\/span>\u548c\u7b2c14\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6297\u4f53\u94fe\u7684V\u533a\u6784\u6210\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\uff0cC\u533a\u63d0\u4f9b\u7279\u6b8a\u6548\u5e94\u529f\u80fd\uff0c\u5982\u4e0e\u7ec6\u80de\u53d7\u4f53\u6216\u8865\u4f53\u86cb\u767d\u7ed3\u5408<\/span>\u3002\u6297\u4f53\u591a\u6837\u6027\u662f\u901a\u8fc7\u91cd\u7ec4\u4e0d\u540c\u7684\u57fa\u56e0\u7247\u6bb5\uff0c\u6784\u5efa\u4e0d\u540c\u7684V\u533a\u4ea7\u751f\u7684\u3002\u8fd9\u5927\u5927\u51cf\u5c11\u4e86\u539f\u672c\u7f16\u7801\u5927\u91cf\u4e0d\u540c\u6297\u4f53\u5206\u5b50\u7684\u57fa\u56e0\u6570\u91cf\uff0c\u4e5f\u51cf\u5c11\u4e86\u6297\u4f53\u5206\u5b50\u57fa\u56e0\u7684\u57fa\u56e0\u7ec4\u6570\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 6.1<\/span> \u514d\u75ab\u7403\u86cb\u767d\u57fa\u56e0\u5ea7\u7684\u57fa\u56e0\u7ec4\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 6.2<\/span> \u514d\u75ab\u7403\u86cb\u767d\u53ef\u53d8\u533a\u7531\u57fa\u56e0\u7247\u6bb5\u91cd\u7ec4\u800c\u6210<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 6.3<\/span> \u8f7b(A)\u548c\u91cd(B)\u514d\u75ab\u7403\u86cb\u767d(Ig)\u94fe\u5408\u6210\u7684\u4e3b\u8981\u6b65\u9aa4<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6700\u521d\u7684\u57fa\u56e0\u91cd\u6392\u53d1\u751f\u4e4b\u540e(\u89c1Fig6.2<\/span>)\uff0c\u6574\u4e2a\u57fa\u56e0\uff0c\u5305\u62ec\u5916\u663e\u5b50(\u7f16\u7801\u5e8f\u5217)\u548c\u5185\u542b\u5b50(\u975e\u7f16\u7801\u5e8f\u5217)\u88ab\u8f6c\u5f55\u6210\u4e00\u4e2a\u521d\u7ea7RNA\u8f6c\u5f55\u672c(\u89c1Fig6.3<\/span>)\u3002\u7136\u540e\u8fdb\u884cRNA\u526a\u63a5\uff0cRNA\u5904\u7406\u9176\u53bb\u9664\u5185\u542b\u5b50\u5e8f\u5217\u4ece\u800c\u4ea7\u751f\u4fe1\u4f7fRNA(mRNA)\uff0c\u53ef\u7ffb\u8bd1\u6210\u86cb\u767d\u8d28\u3002\u7136\u540e\u86cb\u767d\u6c34\u89e3\u9176\u53bb\u9664\u524d\u5bfc(L)\u80bd\u5e8f\u5217(\u89c1Fig6.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8f7b\u94fe\u57fa\u56e0\u7684V\u533a\u7531V\u3001J\u7247\u6bb5\u7ec4\u6210\uff0c\u91cd\u94fe\u57fa\u56e0\u7684V\u533a\u7531V\u3001D\u548cJ\u4e09\u4e2a\u7247\u6bb5\u7ec4\u6210(\u89c1Fig6.2<\/span>)\u3002\u4e3a\u4e86\u8f6c\u5f55\u4e00\u4e2a\u5b8c\u6574\u7684V\u533a\uff0cV\u533a\u57fa\u56e0\u7247\u6bb5(V\u548cJ\u6216V\u3001D\u548cJ)\u5fc5\u987b\u88ab\u201c\u5207\u5272\u201d\uff0c\u7136\u540e\u7531\u8d1f\u8d23DNA\u91cd\u7ec4\u7684\u9176\u8fde\u63a5\u5728\u4e00\u8d77\u3002\u4f8b\u5982\uff0c\u6765\u81eaJ\u6bb5\u5e8f\u5217\u96c6\u5408\u7684\u4e00\u4e2aJ\u6bb5\u4e0e\u6765\u81eaV\u6bb5\u5e8f\u5217\u96c6\u5408\u7684\u4e00\u4e2aV\u6bb5\u7ec4\u5408\u4ee5\u5f62\u6210VL<\/sub>\u533a\u57df\u3002\u7c7b\u4f3c\u5730\uff0c\u4e00\u4e2aV\u6bb5\u3001\u4e00\u4e2aD\u6bb5\u548c\u4e00\u4e2aJ\u6bb5\u88ab\u91cd\u65b0\u6392\u5217\u5f62\u6210VH\u533a\u57df\u3002\u9996\u5148\u5c06D\u548cJ\u7247\u6bb5\u8fde\u63a5\u8d77\u6765\uff0c\u7136\u540e\u5c06V\u57fa\u56e0\u7247\u6bb5\u4e0eD\u3001J\u7247\u6bb5\u8fde\u63a5\u8d77\u6765\uff0c\u521b\u5efa\u4e00\u4e2a\u5b8c\u6574\u7684VH<\/sub>\u5916\u663e\u5b50(\u89c1Fig6.2<\/span>)\u3002\u56e0\u4e3a\u6709\u591a\u4e2aV\u3001D\u548cJ\u57fa\u56e0\u7247\u6bb5(\u89c1Fig6.1<\/span>)\uff0c\u53ef\u4ee5\u521b\u5efa\u8bb8\u591a\u4e0d\u540c\u3001\u5b8c\u6574\u7684\u53ef\u53d8\u533a\u3002\u4f8b\u5982\uff0cV1\u4e0eJ2\u7ed3\u5408\u7684VL<\/sub>\u533a\uff0cV6\u4e0eJ2\u7ed3\u5408\u5f62\u6210\u7684VL<\/sub>\u533a\u5177\u6709\u4e0d\u540c\u7684\u6297\u539f\u7279\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6dcb\u5df4\u7ec6\u80de\u4e2d\u53c2\u4e0e\u4f53\u7ec6\u80de\u91cd\u7ec4\u7684\u9176\u590d\u5408\u7269\u79f0\u4e3aV(D)J\u91cd\u7ec4\u9176\u3002\u8fd9\u4e9b\u9176\u8d1f\u8d23\u91cd\u6392\u8fc7\u7a0b\u4e2d\u7ec6\u80deDNA\u7684\u5207\u5272\u548c\u91cd\u65b0\u8fde\u63a5\u3002\u5176\u4e2d\u6709\u4e24\u79cd\u9176\u662f\u91cd\u7ec4\u6fc0\u6d3b\u57fa\u56e0RAG1\u548cRAG2\u7684\u4ea7\u7269\uff0c\u8d1f\u8d23\u53c2\u4e0eIg\u57fa\u56e0\u4f53\u7ec6\u80de\u91cd\u7ec4\u7684\u7b2c\u4e00\u6b65\u5207\u5272\u3002RAG-1\u548cRAG-2\u9176\u4ec5\u5b58\u5728\u4e8e\u6dcb\u5df4\u7ec6\u80de\u4e2d\uff0c\u8fd9\u4e9b\u9176\u7684\u7f3a\u9677\u4f1a\u5bfc\u81f4\u6dcb\u5df4\u7ec6\u80de\u53d1\u80b2\u53d7\u963b(\u89c1Box7.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u6b64\uff0cB\u7ec6\u80de\u8054\u54082\u53f7\u67d3\u8272\u4f53(\u03ba\u8f7b\u94fe)\u621622\u53f7\u67d3\u8272\u4f53(\u03bb\u8f7b\u94fe)\u4e0e14\u53f7\u67d3\u8272\u4f53(\u91cd\u94fe)\u4ea7\u751fIg\u3002\u6bcf\u4e2a\u7ec6\u80de\u90fd\u67092\u4e2a\u57fa\u56e0\u5206\u522b\u7ee7\u627f\u4e8e\u53cc\u4eb2\uff1b\u6bcf\u4e2a\u57fa\u56e0\u7684\u4e00\u4e2a\u62f7\u8d1d\u9700\u8981\u88ab\u6c89\u9ed8\uff1a\u5982\u679c\u540c\u65f6\u5904\u7406\u6765\u81ea\u6bcd\u7cfb\u548c\u7236\u7cfb\u57fa\u56e0\u7684\u53ef\u53d8\u7247\u6bb5\uff0cB\u7ec6\u80de\u53ef\u4ee5\u4ea7\u751f\u4e24\u79cd\u4e0d\u540c\u7684\u6297\u4f53\u7279\u5f02\u6027\u3002\u53cc\u4eb2\u6216\u6bcd\u4f53\u57fa\u56e0\u6c89\u9ed8\u7684\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u7b49\u4f4d\u57fa\u56e0\u6392\u65a5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 6.4<\/span> \u03ba\u8f7b\u94fe\u5408\u6210\u8be6\u60c5<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u7b2c\u56db\u7ae0\u6240\u8ff0\uff0c\u4e24\u79cd\u7c7b\u578b\u7684\u8f7b\u94fe\u662fkappa(\u03ba)\u548clambda(\u03bb)\u3002\u5f15\u53d1\u03ba\u8f7b\u94fe\u5408\u6210\u7684\u8fc7\u7a0b\u5982Fig6.4<\/span>\u4e2d\u6240\u793a\uff0c\u5e76\u5728\u4e0b\u9762\u63cf\u8ff0\u3002\u5408\u6210\u03bb\u8f7b\u94fe\u7684\u8fc7\u7a0b\u57fa\u672c\u76f8\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4eba\u7c7b\u751f\u6b96\u7cfb\u4e2d\u76842\u53f7\u67d3\u8272\u4f53\u7684\u03ba\u4f4d\u70b9\u4e0a\u53d1\u73b0\u4e86\u5927\u7ea635\u4e2a\u4e0d\u540c\u7684 Vk<\/sub> \u57fa\u56e0\uff0c\u6bcf\u4e2a Vk<\/sub> \u57fa\u56e0\u7f16\u7801N\u7aef(\u03ba\u53ef\u53d8\u533a\u768495\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa)\u3002Vk\u533a(\u53733\u2018)\u4e0b\u6e38\u67095\u4e2aJk<\/sub>\u5916\u663e\u5b50\u3002\u6bcf\u4e2aJk<\/sub>\u7247\u6bb5\u7f16\u7801\u03ba\u53ef\u53d8\u533a\u7684\u7b2c96\u5230\u7b2c108\u4e2a\u6c28\u57fa\u9178\u3002\u5728\u957f\u5185\u542b\u5b50\u4e4b\u540e\uff0c\u03ba\u4f4d\u70b9\u7ec8\u6b62\u4e8e\u7f16\u7801\u03ba\u8f7b\u94fe\u6052\u5b9a\u533a\u7684\u4e00\u4e2aCk<\/sub>\u5916\u663e\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u5408\u6210\u03ba\u8f7b\u94fe\uff0c\u5904\u4e8eB\u6dcb\u5df4\u7ec6\u80de\u65e9\u671f\u7684\u7ec6\u80de(\u7b2c14\u7ae0<\/span>)\u9009\u62e9\u4e00\u4e2aVk<\/sub>\u5916\u663e\u5b50(\u5982Vk<\/sub>3)\uff0c\u7ecf\u8fc7V(D)J\u91cd\u7ec4\u9176\u7684\u91cd\u6392\u540e\uff0c\u5c06\u5176\u8fde\u63a5\u5230\u4e00\u4e2aJ\u7247\u6bb5(\u5982Jk<\/sub>2)\u3002\u5728\u672c\u4f8b\u4e2d\uff0c\u5c06\u5927\u7ea6\u4eceV3\u76843\u2018\u7aef\u5230J2\u76845\u2019\u7aef\u4e2d\u95f4\u7684\u901a\u8fc7DNA\u5faa\u73af\u5c06\u5176\u5207\u5272\u51fa\u6765\uff0c\u6700\u7ec8\u964d\u89e3\u3002\u7136\u540e\u91cd\u6392\u7684DNA\u8f6c\u5f55\u4ea7\u751f\u4e00\u4e2a\u521d\u7ea7RNA\u8f6c\u5f55\u672c(\u89c1Fig6.4<\/span>)\u3002\u8be5\u521d\u7ea7RNA\u8f6c\u5f55\u672c\u901a\u8fc7RNA\u526a\u63a5\u540e\u5f62\u6210\u6210\u719f\u7684mRNA\uff0c\u5982Vk<\/sub>3\u3001Jk<\/sub>2\u548cCk<\/sub>\u5916\u663e\u5b50\u4e00\u8d77\u4ea7\u751f\u6210\u719f\u7684mRNA\u3002\u526a\u63a5\u53bb\u9664\u4e86\u6240\u6709\u7684\u4e2d\u95f4\u5e8f\u5217(\u5982J3\u3001J4\u548cJ5)\uff0c\u4ece\u800c\u5141\u8bb8RNA\u7ffb\u8bd1\u6210\u7ec6\u80de\u5185\u8d28\u7f51\u4e2d\u7684\u03ba\u591a\u80bd\u94fe\u3002\u03bb\u94fe\u57fa\u56e0\u7684\u8fc7\u7a0b\u4e0e\u6b64\u76f8\u4f3c\uff0c\u53ea\u662f\u5728\u4eba\u7c7b22\u53f7\u67d3\u8272\u4f53\u4e0a\u53d1\u73b0\u4e86\u03bb\u5b58\u5728\u5927\u7ea630V\u03bb<\/sub>\u548c4\u4e2aJ\u03bb<\/sub>\u57fa\u56e0\uff0c\u6bcf\u4e2aJ\u03bb<\/sub>\u57fa\u56e0\u90fd\u4e0e\u4e0d\u540c\u7684C\u03bb<\/sub>\u57fa\u56e0\u76f8\u5173(\u89c1Fig6.1<\/span>)\uff0c\u56e0\u6b64\uff0c\u5728\u4eba\u7c7b\u4e2d\u53ef\u80fd\u5b58\u5728\u56db\u79cd\u4e0d\u540c\u7684\u03bb\u8f7b\u94fe\u4e9a\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4eba\u7c7b\u91cd\u94fe<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4eba\u7c7b\u57fa\u56e0\u7ec414\u53f7\u67d3\u8272\u4f53\u4e0a\u7684\u91cd\u94fe\u4f4d\u70b9\u4e0a\uff0c\u5927\u7ea6\u670950\u4e2aVH<\/sub>\uff0c25\u4e2aDH<\/sub>\u548c6\u4e2aJH<\/sub>\u57fa\u56e0\u7247\u6bb5\u5b58\u5728(\u89c1Fig6.1<\/span>)\u3002\u591a\u6837\u6027(D)\u7247\u6bb5\u548cJ\u7247\u6bb5\u4e00\u6837\uff0c\u7f16\u7801\u91cd\u94fe\u7b2c\u4e09\u9ad8\u53d8\u533a(hv3)\u7684\u6c28\u57fa\u9178\u3002\u672f\u8bed\u201c\u9ad8\u53d8\u533a\u201d\u7528\u4e8eIg\u548cTCR\u591a\u6837\u6027\u7684\u8ba8\u8bba(\u7b2c7\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u91cd\u94fe\u5408\u6210\u7684\u673a\u5236(Fig6.5<\/span>)\u4e0e\u03ba\u8f7b\u94fe\u7684\u5408\u6210\u673a\u5236\u975e\u5e38\u76f8\u4f3c\uff0c\u4e0d\u540c\u7684\u662fVH<\/sub>\u5916\u663e\u5b50\u7684\u7ec4\u88c5\u9700\u8981\u4e09\u4e2a\u7247\u6bb5\u800c\u4e0d\u662f\u4e24\u4e2a\uff0c\u5e76\u4e14\u91cd\u94fe\u4f4d\u70b9\u4e2d\u5b58\u5728\u591a\u4e2aCH<\/sub>\u5916\u663e\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9996\u5148\u8fde\u63a5D\u548cJ\u7247\u6bb5\uff0c\u7136\u540e\u5c06V\u7247\u6bb5\u8fde\u63a5\u5230\u7ec4\u5408\u7684DJ\u7247\u6bb5\u5f62\u6210\u5b8c\u6574\u7684VH<\/sub>\u5916\u663e\u5b50\u3002\u5728\u91cd\u94feRNA\u8f6c\u5f55\u672c\u7684\u52a0\u5de5\u8fc7\u7a0b\u4e2d\uff0cC\u533a\u5916\u663e\u5b50\u88ab\u526a\u63a5\u5230VH<\/sub>\u5916\u663e\u5b50\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982Fig6.5<\/span>\u6240\u793a\uff0c\u5b58\u5728\u591a\u4e2a\u4e0d\u540c\u7684CH<\/sub>\u533a\u57df\u3002\u4efb\u610f\u7ed9\u5b9a\u7684VH<\/sub>\u533a\u90fd\u53ef\u4ee5\u901a\u8fc7\u7c7b\u8f6c\u6362\u7684DNA\u91cd\u6392\u8fc7\u7a0b\u4e0e\u4efb\u4f55CH<\/sub>\u533a\u4e00\u8d77\u8868\u8fbe\u3002\u4e0d\u540c\u7684CH<\/sub>\u533a\u5177\u6709\u4e0d\u540c\u7684\u751f\u7269(\u6548\u5e94)\u529f\u80fd\u3002\u8fd9\u5141\u8bb8\u66f4\u591a\u7684\u591a\u6837\u6027\uff0c\u56e0\u4e3a\u76f8\u540c\u7684\u6297\u539f\u7279\u5f02\u6027(V\u533a)\u53ef\u4ee5\u4e0e\u8d4b\u4e88\u4e0d\u540c\u6548\u5e94\u5668\u5c5e\u6027\u7684CH<\/sub>\u533a\u76f8\u5173\u8054\uff0c\u4f8b\u5982\uff0c\u7a7f\u8fc7\u80ce\u76d8\u7684\u80fd\u529b\u6216\u4e0e\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u4e0a\u7684\u4e0d\u540c\u7ec4\u5206\u7ed3\u6676\u578b(Fc)\u53d7\u4f53\u7ed3\u5408\u7684\u80fd\u529b(\u89c1Fig4.7<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 6.5<\/span> \u91cd\u94fe\u5408\u6210\u7ec6\u8282\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u6297\u4f53\u591a\u6837\u6027\u7684\u4ea7\u751f<\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u4ea7\u751f\u6297\u539f\u53d7\u4f53\u591a\u6837\u6027\uff0cB\u7ec6\u80de\u91c7\u7528\u5982\u4e0b\u6240\u8ff0\u7684\u9057\u4f20\u673a\u5236\uff1a<\/p>\n

1.V\u3001D\u548cJ\u57fa\u56e0\u7247\u6bb5\u6709\u591a\u4e2a\u62f7\u8d1d\uff0c\u4f8b\u5982\u5927\u7ea6\u670935\u4e2aVk\u57fa\u56e0\u7247\u6bb5\u3002\u8fd9\u5c31\u662f\u6240\u8c13\u7684\u79cd\u7cfb\u591a\u6837\u6027\u3002<\/p>\n

2.VJ\u548cVDJ\u57fa\u56e0\u7247\u6bb5\u4ee5\u591a\u79cd\u7ec4\u5408\u91cd\u7ec4\uff0c\u79f0\u4e3a\u7ec4\u5408\u591a\u6837\u6027\uff0c\u4f8b\u5982\uff0c35\u4e2aVk<\/sub>\u548c5\u4e2aJk<\/sub>\u7247\u6bb5\u53ef\u4ee5\u5f62\u6210175\u6761(35\u00d75)\u4e0d\u540c\u53ef\u53d8\u533a\u7684\u4eba\u03ba\u8f7b\u94fe\u3002<\/p>\n

3.\u57fa\u56e0\u7247\u6bb5\u4e4b\u95f4\u5f62\u6210\u8fde\u63a5\u3002\u4f8b\u5982\uff0cV\u57fa\u56e0\u7247\u6bb5\u4e0e\u91cd\u6392\u7684DJ\u57fa\u56e0\u7247\u6bb5\u7684\u8fde\u63a5\u6d89\u53caDNA\u5207\u5272\uff0c\u968f\u540e\u662f\u6838\u82f7\u9178\u7684\u52a0\u51cf\uff0c\u4ee5\u521b\u5efa\u4e00\u4e2a\u8fde\u63a5\u70b9(Table6.1<\/span>)\u3002\u8fd9\u4e9b\u4e8b\u4ef6\u7684\u7ed3\u679c\u662f\uff0c\u4e0d\u540cB\u7ec6\u80de\u4e2d\u8fde\u63a5\u70b9\u5904\u53ef\u4ea7\u751f\u4e0d\u540c\u7684\u7f16\u7801\u5e8f\u5217\uff0c\u4f8b\u5982\uff0c\u901a\u8fc7\u9176\u672b\u7aef\u8131\u6c27\u6838\u82f7\u9178\u8f6c\u79fb\u9176(TDT)\u968f\u673a\u6dfb\u52a0\u6838\u82f7\u9178\u3002\u4e0d\u540c\u5e8f\u5217\u4f1a\u4ea7\u751f\u66f4\u5927\u7684\u6297\u4f53\u591a\u6837\u6027\uff0c\u5373\u8fde\u63a5\u591a\u6837\u6027\u3002\u5982Fig6.6<\/span>\u6240\u793a\uff0c\u5047\u5b9a\u7ed3\u5408\u4f4d\u70b9\u4e0a\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u53ef\u4ee5\u4ece-Ala-Arg-Asn-\u53d8\u4e3a-Ala-Arg-Ile-\uff0c\u8fd9\u662f\u4e3b\u8981\u5316\u5b66\u7ed3\u6784\u53d8\u5316\uff0c\u53ea\u9700\u5728VH<\/sub>\u4e0e DH<\/sub>  JH<\/sub>\u7247\u6bb5\u7684\u8fde\u63a5\u8fc7\u7a0b\u4e2d\u5220\u9664\u4e00\u4e2a\u6838\u82f7\u9178\u5373\u53ef\u3002<\/p>\n

4.\u8f7b\u94fe\u548c\u91cd\u94fe\u53ef\u4ee5\u6709\u591a\u79cd\u7ec4\u5408\u3002\u539f\u5219\u4e0a\uff0c\u4efb\u4f55\u91cd\u94fe\u90fd\u53ef\u4ee5\u4e0e\u4efb\u4f55\u8f7b\u94fe\u7ed3\u5408\u3002\u56e0\u4e3a\u8fd9\u4e24\u6761\u94fe\u90fd\u662f\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\uff0c\u6240\u4ee5\u8fd9\u79cd\u968f\u673a\u6392\u5217\u7684\u8f7b\u94fe\u548c\u91cd\u94fe\u4f1a\u4ea7\u751f\u4e0d\u540c\u7684\u6297\u4f53\u7279\u5f02\u6027\u3002\u4f8b\u5982\uff0c200\u4e2a\u4e0d\u540c\u7684\u8f7b\u94fe\u4e0e2000\u4e2a\u4e0d\u540c\u7684\u91cd\u94fe\u968f\u673a\u7ed3\u5408\uff0c\u53ef\u80fd\u4f1a\u4ea7\u751f420(4\u00d7105<\/sup>)\u4e2a\u4e0d\u540c\u6297\u4f53\u3002<\/p>\n

5.\u6297\u539f\u523a\u6fc0\u540e\u53ef\u53d1\u751f\u4f53\u7ec6\u80de\u9ad8\u7a81\u53d8\u3002\u5728\u7ec4\u88c5\u4e86\u529f\u80fd\u6027\u6297\u4f53\u57fa\u56e0\uff0cB\u7ec6\u80de\u5bf9\u6297\u539f\u4ea7\u751f\u53cd\u5e94\u540e\uff0c\u53e6\u4e00\u79cd\u673a\u5236\uff0c\u79f0\u4e3a\u4f53\u7ec6\u80de\u9ad8\u7a81\u53d8\uff0c\u5728V\u533a\u4ea7\u751f\u989d\u5916\u7684\u591a\u6837\u6027\u3002\u8fd9\u4e2a\u673a\u5236\u7684\u4f5c\u7528\u662f\u4ee5\u975e\u5e38\u9ad8\u7684\u6bd4\u7387\u5c06\u70b9\u7a81\u53d8\u5f15\u5165\u91cd\u94fe\u548c\u8f7b\u94fe\u7684V\u533a\u3002\u4e00\u4e9b\u7a81\u53d8\u4ea7\u751f\u7684\u6297\u4f53\u5206\u5b50\u6bd4\u201c\u539f\u59cb\u201d\u6297\u4f53\u66f4\u9002\u5408\u6297\u539f\u3002\u8fd9\u4e9b\u65b0\u6297\u4f53\u4ee5\u66f4\u9ad8\u7684\u4eb2\u548c\u529b\u7ed3\u5408\u6297\u539f\uff0c\u8868\u8fbe\u5b83\u4eec\u7684B\u7ec6\u80de\u88ab\u4f18\u5148\u9009\u62e9\u6210\u719f\u4e3a\u6d46\u7ec6\u80de(\u7b2c14\u7ae0)<\/span><\/span>\u3002\u8fd9\u79cd\u73b0\u8c61\u6709\u65f6\u88ab\u79f0\u4e3a\u4e2a\u4f53\u4e2d\u6297\u4f53\u5206\u5b50\u7fa4\u4f53\u7684\u4eb2\u548c\u6210\u719f(affinity maturation)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f53B\u7ec6\u80de\u5bf9\u6301\u7eed\u611f\u67d3\u6709\u53cd\u5e94\u65f6\uff0c\u7528\u9176\u8054\u514d\u75ab\u5438\u9644\u8bd5\u9a8c(ELISA)\u6d4b\u5b9a\u7684\u6297\u4f53\u6570\u91cf\u9010\u6e10\u589e\u52a0\u3002\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u4ea7\u751f\u66f4\u591a\u7684B\u7ec6\u80de\uff0c\u8fdb\u800c\u5206\u6ccc\u66f4\u591a\u6297\u4f53\u3002\u53e6\u5916\uff0c\u7531\u4e8e\u53d1\u751f\u4e86\u4f53\u7ec6\u80de\u7a81\u53d8\uff0c\u4ea7\u751f\u7684\u6297\u4f53\u7684\u8d28\u91cf\u5f97\u5230\u4e86\u63d0\u9ad8\uff0c\u4eb2\u548c\u529b\u66f4\u9ad8\u3002\u611f\u67d3\u88ab\u6e05\u9664\u540e\uff0c\u90e8\u5206B\u7ec6\u80de\u5c31\u4f1a\u4f5c\u4e3a\u8bb0\u5fc6B\u7ec6\u80de\u5b58\u6d3b\u4e0b\u6765\u3002\u8fd9\u4e9b\u7ec6\u80de\u6765\u6e90\u4e8eB\u7ec6\u80de\uff0c\u7531\u4e8e\u4eb2\u548c\u6210\u719f\uff0cB\u7ec6\u80de\u5206\u6ccc\u4e86\u6700\u4f73\u7684\u514d\u75ab\u7403\u86cb\u767d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 6.6<\/span>\u7ec6\u80de\u8868\u9762(\u8de8\u819c)\u548c\u5206\u6ccc\u5f62\u5f0f\u7684\u514d\u75ab\u7403\u86cb\u767d(Ig)\u3002pAs.\u5206\u6ccc\u578b\u7684\u805a\u817a\u82f7\u9178\u5316\u4f4d\u70b9; pAm.\u819c\u7ed3\u5408\u578b\u7684\u805a\u817a\u82f7\u9178\u5316\u4f4d\u70b9<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7403\u86cb\u767d\u7c7b\u522b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7c7b\u522b\u8f6c\u6362<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u7b2c\u56db\u7ae0\u6240\u8ff0\uff0c\u4eba\u514d\u75ab\u7403\u86cb\u767d\u6709\u4e94\u7c7b\uff0c\u5206\u522b\u662fIgM\u3001IgD\u3001IgG\u3001IgE\u548cIgA\u3002\u8fd9\u4e9bIgs\u4e2d\u7684\u6bcf\u4e00\u4e2a\u90fd\u6709CH<\/sub>\u57fa\u56e0(\u89c1Fig6.5<\/span>)\uff0c\u76f8\u540c\u7684VH<\/sub>\u5916\u663e\u5b50\u53ef\u4ee5\u91cd\u65b0\u6392\u5217\uff0c\u4ee5\u4fbf\u5728\u514d\u75ab\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u7684\u4e0d\u540c\u65f6\u95f4\u4e0e\u4e0d\u540c\u7684CH<\/sub>\u5916\u663e\u5b50\u76f8\u5173\u8054\u3002\u4f8b\u5982\uff0c\u5728\u5bf9\u6297\u539f\u7684\u514d\u75ab\u53cd\u5e94\u65e9\u671f\uff0cB\u7ec6\u80de\u603b\u662f\u8868\u8fbeIgM\uff0c\u968f\u540e\uff0c\u5728\u5bf9\u540c\u4e00\u6297\u539f\u7684\u53cd\u5e94\uff0c\u7ec4\u88c5\u7684V\u533a\u53ef\u5728IgG\u6297\u4f53\u4e2d\u8868\u8fbe\u3002\u8fd9\u79cd\u53d8\u5316\u6d89\u53ca\u7279\u5b9a\u533a\u57df\u4e4b\u95f4\u7684DNA\u91cd\u7ec4\uff0c\u79f0\u4e3a\u5207\u6362\u533a<\/span>\u3002\u4f7f\u7528\u4e0d\u540c\u7684\u6052\u5b9a\u533a\u57df\u53ef\u521b\u5efa\u989d\u5916\u7684\u591a\u6837\u6027\uff0c\u56e0\u4e3a\u4e0d\u540c\u7684\u6548\u5e94\u5668\u529f\u80fd\u4e0e\u4e0d\u540c\u7684C\u533a\u57df\u76f8\u5173\u8054\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7c7b\u522b\u8f6c\u6362\u4f7fB\u7ec6\u80de\u80fd\u591f\u6839\u636e\u7279\u5b9a\u60c5\u51b5\u5b9a\u5236\u6297\u4f53\u3002\u4f8b\u5982\uff0cIgM\u662f\u4e00\u79cd\u76f8\u5f53\u6709\u7528\u7684\u6297\u4f53\uff0c\u7528\u4e8e\u6cbb\u7597\u8840\u6db2\u4e2d\u7684\u611f\u67d3\uff0c\u4f46\u5176\u9ad8\u5206\u5b50\u91cf\u963b\u6b62\u4e86\u5b83\u6269\u6563\u5230\u7ec4\u7ec7\u4e2d\u3002\u56e0\u6b64\uff0cB\u7ec6\u80de\u5728\u5bf9\u7ec4\u7ec7\u611f\u67d3(\u5982\u8113\u80bf)\u4f5c\u51fa\u53cd\u5e94\u65f6\uff0c\u4f1a\u53d1\u751f\u7c7b\u522b\u8f6c\u6362\uff0c\u4ea7\u751fIgG\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u514d\u75ab\u7cfb\u7edf\u8fdb\u5316\u51faIgA\u4ee5\u5e94\u5bf9\u7c98\u819c\u8868\u9762(\u5982\u80a0\u9053)\u7684\u611f\u67d3\u3002B\u7ec6\u80de\u4f1a\u56e0\u80a0\u9053\u611f\u67d3\u4eceIgM\u8f6c\u53d8\u4e3aIgA\u7ec6\u80de\uff0c\u672c\u7ae0\u4e2d\u7684box\u63cf\u8ff0\u4e86\u8fd9\u4e9b\u77e5\u8bc6\u5982\u4f55\u5e2e\u52a9\u8bca\u65ad\u611f\u67d3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u819c\u7ed3\u5408\u578b\u548c\u5206\u6ccc\u578b\u514d\u75ab\u7403\u86cb\u767d<\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u80fd\u4ea7\u751f\u819c\u7ed3\u5408\u6216\u5206\u6ccc\u5f62\u5f0f\u7684Igs\u3002\u819c\u7ed3\u5408\u578bIg\u5728\u91cd\u94fe\u7684\u672b\u7aef\u6709\u5927\u7ea630\u4e2a\u989d\u5916\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u3002\u8fd9\u4e9b\u6b8b\u57fa\u4e2d\u5305\u62ec\u4e00\u6bb5\u5927\u7ea6\u957f\u5ea6\u4e3a25\u7684\u758f\u6c34\u6c28\u57fa\u9178\uff0c\u5b83\u4eec\u5c06Ig\u951a\u5b9a\u5728\u7ec6\u80de\u819c\u4e0a\uff0c\u5728\u90a3\u91cc\u5b83\u53ef\u4ee5\u4f5c\u4e3a\u53d7\u4f53\u53d1\u6325\u4f5c\u7528(\u89c1\u7b2c11\u7ae0)\u3002\u8fd9\u4e24\u79cd\u4e0d\u540c\u7684\u5f62\u5f0f\u5728\u4e0d\u540c\u7684CH<\/sub>\u5916\u663e\u5b50\u4e2d\u7f16\u7801\uff0c\u5e76\u4e14\u4e0d\u540c\u7684RNA\u52a0\u5de5\u65b9\u5f0f (\u89c1Fig6.6<\/span>)\u7528\u4e8e\u4ea7\u751f\u5206\u6ccc\u578b\u6216\u819c\u7ed3\u5408\u578bIgs\u3002\u540c\u6837\uff0c\u8fd9\u79cdRNA\u9009\u62e9\u6027\u52a0\u5de5\u4ee5\u53ca\u591a\u805a\u817a\u82f7\u9178\u4f4d\u70b9\u9009\u62e9\u7684\u8c03\u8282\u673a\u5236\u8fd8\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u53ef\u80fd\u4e0e\u6297\u539f\u7ed3\u5408\u548c\/\u6216\u4e0eT\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u4ea7\u751f\u7684\u4fe1\u53f7\u6709\u5173(\u7b2c16\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 6.1 <\/span>\u4f7f\u7528\u6297\u4f53\u8bca\u65ad\u6025\u6027\u4e59\u578b\u809d\u708e\u611f\u67d3<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u4e00\u4f4d29\u5c81\u7684\u5973\u6027\u60a3\u8005\uff0c\u67094\u5468\u8f7b\u5ea6\u53d1\u70e7\u3001\u4f53\u91cd\u51cf\u8f7b\u548c\u9ec4\u75b8\u75c5\u53f2\u3002\u5e76\u4e14\u6709\u4e0e\u591a\u4e2a\u4f34\u4fa3\u53d1\u751f\u65e0\u4fdd\u62a4\u63aa\u65bd\u6027\u884c\u4e3a\u7684\u5386\u53f2\uff0c\u6709\u4e00\u4e9b\u81ea\u5236\u7eb9\u8eab\u3002\u9664\u4e86\u660e\u663e\u7684\u809d\u529f\u80fd\u5f02\u5e38\u5916\uff0c\u75c5\u6bd2\u5b66\u8bca\u65ad\u7ed3\u679c\u53ef\u4ee5\u5e2e\u52a9\u5224\u65ad\u5979\u9ec4\u75b8\u7684\u8868\u73b0\u662f\u5426\u7531\u6025\u6027\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u5f15\u8d77\u3002\u8840\u6db2\u68c0\u67e5\u663e\u793a\u7532\u578b\u809d\u708e\u548c\u4e19\u578b\u809d\u708e\u75c5\u6bd2\u7684\u6297\u4f53\u5448\u9634\u6027\uff0c\u8bf4\u660e\u8fd9\u4e9b\u611f\u67d3\u4e0d\u592a\u53ef\u80fd\u662f\u5979\u9ec4\u75b8\u7684\u539f\u56e0\u3002\u5979\u7684\u4e59\u809d\u8868\u9762\u6297\u539f(HBsAg)\u6297\u4f53\u5448\u9633\u6027\uff0c\u4f46\u8fd9\u53ef\u80fd\u4e0e\u63a5\u79cd\u75ab\u82d7\u76f8\u5173\uff0c\u4f46\u5979\u4e0d\u786e\u5b9a\u81ea\u5df1\u662f\u5426\u63a5\u79cd\u8fc7\u75ab\u82d7\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u53e6\u5916\u4e24\u79cd\u60c5\u51b5\u53ef\u4ee5\u6392\u9664\u8fd9\u79cd\u53ef\u80fd\u6027\uff1a<\/p>\n

1\u3001HBsAg\u9633\u6027\u3002\u6297\u539f\uff0c\u4e0d\u662f\u6297\u4f53\uff0c\u53ea\u6709\u5728\u4e59\u809d\u611f\u67d3\u540e\u624d\u80fd\u68c0\u6d4b\u5230\uff0c\u800c\u4e0d\u662f\u5728\u63a5\u79cd\u75ab\u82d7\u540e\u3002\u5979\u7684\u75c5\u6bd2DNA\u4e5f\u5448\u9633\u6027\uff0c\u53ea\u6709\u5728\u611f\u67d3\u540e\u624d\u80fd\u51fa\u73b0\u3002<\/p>\n

2.\u6709\u6297\u4e59\u809d\u6838\u5fc3\u6297\u539f\u6297\u4f53(\u6297HBc)\u3002\u75ab\u82d7\u4e2d\u4e0d\u5b58\u5728\u4e59\u809d\u6838\u5fc3\u6297\u539f(Fig6.7A<\/span>)\uff0c\u56e0\u6b64\u63a5\u79cd\u75ab\u82d7\u4e0d\u4f1a\u4ea7\u751f\u9488\u5bf9\u5b83\u7684\u6297\u4f53\u3002\u800c\u4e59\u809d\u75c5\u6bd2\u4e2d\u5b58\u5728\u8840\u7ea2\u86cb\u767d\uff0c\u5728\u611f\u67d3\u540e\u4f1a\u4ea7\u751f\u9488\u5bf9\u5b83\u7684\u6297\u4f53\u3002\u53ef\u80fd\u8bca\u65ad\u662f\u6211\u4eec\u75c5\u4eba\u9ec4\u75b8\u7684\u539f\u56e0\u662f\u4e59\u578b\u809d\u708e\u611f\u67d3\uff0c\u6162\u6027\u4e59\u578b\u809d\u708e\u611f\u67d3\u8005\u5f80\u5f80\u809d\u529f\u80fd\u6b63\u5e38\u3002\u8fd9\u4e9b\u4eba\u7684\u514d\u75ab\u7403\u86cb\u767dG(IgG)\u6297HBc\u68c0\u6d4b\u5448\u9633\u6027\u3002\u4f46\u8be5\u60a3\u8005\u6709IgM\u6297HBc\uff0c\u8868\u660e\u611f\u67d3\u53d1\u751f\u5728\u8fc7\u53bb\u7684\u51e0\u5468\u5185(<\/span>Fig6.7B<\/span>\uff0cC<\/span>\u548cTable6.2<\/span>)\u3002\u6240\u4ee5\u8bca\u65ad\u4e3a\u6025\u6027\u4e59\u578b\u809d\u708e\u611f\u67d3\u7684\u53ef\u80fd\u6027\u5f88\u5927\u3002<\/span><\/p>\n

\u75c5\u4eba\u5728\u6ca1\u6709\u4efb\u4f55\u7279\u6b8a\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\u9010\u6e10\u611f\u89c9\u597d\u591a\u4e86\u3002\u5979\u7684HBsAg\u548c\u75c5\u6bd2DNA\u6d4b\u8bd5\u5448\u9634\u6027\uff0c\u8868\u660e\u5979\u7684\u8eab\u4f53\u6b63\u5728\u63a7\u5236\u611f\u67d3\u3002\u5979\u7684\u6297HBc\u79cd\u7c7b\u4eceIgM\u8f6c\u5230\u4e86IgG\uff0c\u65f6\u95f4\u624d\u80fd\u8bc1\u660e\u5979\u662f\u5426\u4f1a\u6210\u4e3a\u6162\u6027\u643a\u5e26\u8005\uff0c\u4ee5\u53ca\u5979\u672a\u6765\u662f\u5426\u4f1a\u51fa\u73b0\u66f4\u591a\u4e0e\u4e59\u578b\u809d\u708e\u611f\u67d3\u76f8\u5173\u7684\u95ee\u9898(\u89c1\u7b2c23\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n

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Fig 6.7 <\/span>A.\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u7684\u7ed3\u6784\u3002B.\u53ef\u7528\u4e8e\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u4e0d\u540c\u9636\u6bb5\u7684\u68c0\u6d4b\u3002HBC\uff0c\u4e59\u809d\u6838\u5fc3(\u6297\u539f)\uff1bHBsAg\uff0c\u4e59\u809d\u75c5\u6bd2\u8868\u9762\u6297\u539f
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 | \u949f\u96ea\u83b9<\/span><\/span> <\/span> <\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u5f90\u66fc\u65af<\/span><\/span><\/section>\n
\u5ba1\u6838 |  \u738b\u5764 \u5b8b\u4e50<\/span><\/section>\n

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\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/a><\/a>
<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

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\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u4eba\u4f53\u4f3c\u4e4e\u80fd\u591f\u4ea7\u751f\u65e0\u9650\u91cf\u7684\u6297\u4f53(\u514d\u75ab\u7403\u86cb\u767d[Ig])\u5206\u5b50-\u4e5f\u8bb8\u5b87\u5b99\u4e2d\u7684\u6bcf\u4e2a\u6297\u539f\u81f3\u5c11\u6709\u4e00\u4e2a\uff01\u8ba1\u7b97\u8868\u660e\uff0c\u4eba\u7c7b…<\/p>\n","protected":false},"author":1,"featured_media":1861,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[64],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1862"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=1862"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1862\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/1861"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=1862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=1862"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=1862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}