{"id":1866,"date":"2021-03-09T17:13:04","date_gmt":"2021-03-09T09:13:04","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2021\/03\/09\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac8%e7%ab%a0%ef%bc%9a%e4%b8%bb%e8%a6%81%e7%bb%84%e7%bb%87%e7%9b%b8%e5%ae%b9%e6%80%a7%e5%a4%8d%e5%90%88%e7%89%a9mhc\/"},"modified":"2021-03-09T17:13:04","modified_gmt":"2021-03-09T09:13:04","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac8%e7%ab%a0%ef%bc%9a%e4%b8%bb%e8%a6%81%e7%bb%84%e7%bb%87%e7%9b%b8%e5%ae%b9%e6%80%a7%e5%a4%8d%e5%90%88%e7%89%a9mhc","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2021\/03\/09\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac8%e7%ab%a0%ef%bc%9a%e4%b8%bb%e8%a6%81%e7%bb%84%e7%bb%87%e7%9b%b8%e5%ae%b9%e6%80%a7%e5%a4%8d%e5%90%88%e7%89%a9mhc\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC"},"content":{"rendered":"
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\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\u662fDNA\u7684\u4e00\u4e2a\u533a\u57df\uff0c\u4e3a\u4e00\u7ec4\u8bc6\u522b\u6297\u539f\u7684\u5206\u5b50\u7f16\u7801\u3002\u4e0d\u540c\u751f\u7269\u7684MHC\u6709\u7279\u5b9a\u7684\u540d\u79f0\u3002\u5728\u4eba\u7c7b6\u53f7\u67d3\u8272\u4f53\u4e0a\u53d1\u73b0\u7684\u4eba\u7c7bMHC\u88ab\u79f0\u4e3a\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f(HLA)\u3002\u5f53\u5177\u4f53\u63d0\u5230HLA\u57fa\u56e0\u6216HLA\u5206\u5b50\u65f6(\u4f8b\u5982\uff0cHLA-A\u57fa\u56e0\u7f16\u7801HLA-A\u5206\u5b50)\u3002\u5982\u7b2c3\u7ae0<\/span>\u6240\u8ff0\uff0cHLA\u5206\u5b50\u662f\u6297\u539f\u8bc6\u522b\u5206\u5b50\uff0c\u4e0e\u6297\u4f53\u548cT\u7ec6\u80de\u53d7\u4f53(TCR)\u662f\u6297\u539f\u8bc6\u522b\u5206\u5b50\u4e00\u6837\u3002\u7136\u800c\uff0c\u76f4\u5230\u83b7\u5f97\u4e86HLA\u5206\u5b50\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u4eba\u4eec\u624d\u6e05\u695aHLA\u5206\u5b50\u4f5c\u4e3a\u6297\u539f\u8bc6\u522b\u5206\u5b50\u7684\u4f5c\u7528\u3002\u4e0a\u56fe\u6240\u793a\u662fMHC\u7684\u57fa\u56e0\u91cd\u6392\u548cMHC\u57fa\u56e0\u4ea7\u7269\u7684\u7ed3\u6784\u548c\u7ec4\u88c5\u3002MHC\u5206\u5b50\u5c06\u6297\u539f\u80bd\u63d0\u5448\u7ed9T\u7ec6\u80de\u7684\u4f5c\u7528\u4e5f\u88ab\u66f4\u8be6\u7ec6\u5730\u63cf\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u57fa\u56e0\u7684\u6392\u5217<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Fig8.1<\/span>\u663e\u793a\u4e86\u4eba\u7c7bMHC\u4e2d\u7f16\u7801\u57fa\u56e0\u7684\u6392\u5217\uff0c\u53ea\u663e\u793a\u4e86\u4e3b\u8981\u7684\u57fa\u56e0\u4f4d\u70b9\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728HLA\u533a\u57df\u5df2\u7ecf\u53d1\u73b0\u7ea6224\u4e2a\u4f4d\u70b9\u3002\u6b64\u5916\uff0c\u57fa\u56e0\u4f4d\u70b9\u5206\u4e3a\uff1aI\u7c7b\u3001II\u7c7b\u548cIII\u7c7b\u3002\u5982Fig8.2<\/span>\u6240\u793a\uff0c\u5728MHC\u4e2d\u5b58\u5728\u5e7f\u6cdb\u7684\u591a\u6001\u6027(\u5065\u5eb7\u4eba\u7fa4\u4e2d\u5b58\u5728\u5927\u91cf\u7b49\u4f4d\u57fa\u56e0)\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8fd9\u662f\u5df2\u77e5\u7684\u591a\u6001\u4f4d\u70b9\u3002\u7b49\u4f4d\u57fa\u56e0\u7684\u4e0d\u5bfb\u5e38\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u4eec\u5728\u5927\u7ea610-20\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u4e0a\u5b58\u5728\u5dee\u5f02\uff0c\u800c\u4e0d\u4ec5\u4ec5\u53ea\u6709\u4e00\u4e2a\u6216\u51e0\u4e2a\u6b8b\u57fa\u3002Fig8.3<\/span>\u663e\u793a\u4e86\u8be5\u9057\u4f20\u533a\u57df\u7684\u53e6\u4e00\u4e2a\u4e0d\u540c\u5bfb\u5e38\u7684\u7279\u5f81\uff1a\u7b49\u4f4d\u57fa\u56e0(\u5355\u500d\u578b)\u662f\u4e00\u8d77\u9057\u4f20\u7684\uff0c\u800c\u4e14\u5b83\u4eec\u5728\u5bb6\u65cf\u4e2d\u662f\u76f8\u540c\u7684\u3002\u8fd9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u56e0\u4e3aMHC\u4e2d\u7f3a\u4e4f\u57fa\u56e0\u91cd\u7ec4\u3002\u57fa\u56e0\u91cd\u7ec4\u6d89\u53ca\u4ea4\u53c9\uff0c\u5305\u62ecMHC\u7684\u67d3\u8272\u4f53\u7247\u6bb5\u7684\u4ea4\u53c9\u4e8b\u4ef6\u76f8\u5bf9\u8f83\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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HLA  I\u7c7b(A\u3001B\u548cC)\u548cII\u7c7b(DP\u3001DQ\u3001DR)\u57fa\u56e0\u4ea7\u7269(\u89c1Fig8.1<\/span>)\u4e0e\u514d\u75ab\u7403\u86cb\u767d\u548cTCR\u57fa\u56e0\u4ea7\u7269\u4e4b\u95f4\u7684\u4e00\u4e2a\u91cd\u8981\u533a\u522b\u662fMHC\u5206\u5b50\u7b49\u4f4d\u57fa\u56e0\u7684\u5171\u540c\u8868\u8fbe\u3002\u8fd9\u610f\u5473\u7740\u6bcd\u7cfb\u548c\u7236\u7cfb\u884d\u751f\u7684\u7b49\u4f4d\u57fa\u56e0\u90fd\u4ee5\u7ec6\u80de\u8868\u9762\u86cb\u767d\u7684\u5f62\u5f0f\u8868\u8fbe\u3002\u76f8\u53cd\uff0c\u514d\u75ab\u7403\u86cb\u767d\u548cTCR\u57fa\u56e0\u4ea7\u7269\u8868\u73b0\u51fa\u7b49\u4f4d\u57fa\u56e0\u6392\u65a5\u73b0\u8c61\uff1b\u4e5f\u5c31\u662f\u8bf4\uff0c\u6bcf\u4e2a\u7ec6\u80de\u4e0a\u53ea\u8868\u8fbe\u4e00\u79cd\u5f62\u5f0f(\u7b2c6\u7ae0<\/span>)\u3002\u8fd9\u5728Fig8.3<\/span>\u4e2d\u4ee5\u4eba\u7c7b\u5bb6\u5ead\u4e3a\u4f8b\u8fdb\u884c\u4e86\u8bf4\u660e\u3002\u56e0\u6b64\uff0c\u9664\u4e86\u7f55\u89c1\u7684\u91cd\u7ec4\uff0c\u5b69\u5b50\u57fa\u672c\u8868\u8fbe\u7684\u90fd\u662f\u4ed6\u4eec\u4ece\u7236\u6bcd\u90a3\u91cc\u7ee7\u627f\u7684\u5355\u500d\u578b\u3002<\/p>\n

I\u7c7b\u5206\u5b50\u5b58\u5728\u4e8e\u6240\u6709\u6709\u6838\u7ec6\u80de\u4e0a\u3002\u5982\u540e\u9762\u63cf\u8ff0\uff0c\u610f\u5473\u7740\u6240\u6709\u6709\u6838\u7ec6\u80de\u90fd\u53ef\u4ee5\u5448\u9012\u6765\u81ea\u7ec6\u80de\u5185\u75c5\u539f\u4f53\u7684\u6297\u539f\u3002\u8fd9\u4e0eII\u7c7b\u5206\u5b50\u5f62\u6210\u9c9c\u660e\u5bf9\u6bd4\uff0c\u540e\u8005\u662f\u5206\u5316\u6297\u539f\u7684\u4f8b\u5b50\u3002I\u7c7b\u5206\u5b50\u5b58\u5728\u4e8e\u6297\u539f\u63d0\u5448\u7ec6\u80de(APCs)\u4e0a\uff0c\u5305\u62ecB\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u5b83\u4eec\u53ef\u4ee5\u5728\u4eba\u7c7bT\u7ec6\u80de\u4e2d\u88ab\u8bf1\u5bfc\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 8.1 <\/span>\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\u7684\u57fa\u56e0\u6392\u5217<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 8.2<\/span> MHC \u7684\u591a\u6001\u6027(\u6570\u636e\u6765\u81ea\u514d\u75ab\u591a\u6001\u6570\u636e\u5e93)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 8.3  <\/span>A.\u5355\u500d\u578b\u9057\u4f20  B.MHC \u5206\u5b50\u7684\u5171\u663e\u6027\u8868\u8fbe<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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MHC\u57fa\u56e0\u4ea7\u7269\u7684\u7ed3\u6784<\/strong>
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I \u7c7b\u5206\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig8.4<\/span>\u663e\u793a\u4e86I\u7c7b\u57fa\u56e0\u7684\u86cb\u767d\u8d28\u4ea7\u7269\u7684\u7ed3\u6784\u3002I\u7c7b\u5206\u5b50\u662f\u975e\u5171\u4ef7\u7ed3\u5408\u7684\u5f02\u4e8c\u805a\u4f53\uff0c\u5305\u62ec\u5206\u5b50\u91cf\u7ea645,000\u7684\u8de8\u819c\u7cd6\u86cb\u767d(\u03b2\u94fe\uff0cMHC\u4e2d\u7f16\u7801)\u548c\u5206\u5b50\u91cf\u7ea612,000\u4e14\u7f16\u7801\u5728\u5b8c\u5168\u4e0d\u540c\u7684\u67d3\u8272\u4f53\u4e0a(\u4eba\u7c7b\u768415\u53f7\u67d3\u8272\u4f53\u7684\u03b22<\/sub>\u5fae\u7403\u86cb\u767d\u3002\u03b22<\/sub>\u5fae\u7403\u86cb\u767d\u662f\u4e00\u79cd\u53ef\u6eb6\u6027\u86cb\u767d\uff0c\u5b83\u5728\u5185\u8d28\u7f51\u4e2d\u7684\u5408\u6210\u548c\u7ec4\u88c5\u8fc7\u7a0b\u4e2d\u4f1a\u4e0e\u03b1\u94fe\u5f62\u6210\u590d\u5408\u7269\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u662fMHC\u7f16\u7801\u7684\u201c\u91cd\u94fe\u201d\u7684\u591a\u80bd\u7ed3\u5408\u529f\u80fd\u6240\u5fc5\u9700\u7684\u3002\u4e0e\u03b1\u94fe\u4e0d\u540c\u7684\u662f\uff0c\u03b22<\/sub>\u5fae\u7403\u86cb\u767d\u4e0d\u662f\u591a\u6001\u7684\uff1a\u6bcf\u4e2aMHC-I\u7c7b\u5206\u5b50\u90fd\u4f7f\u7528\u5b8c\u5168\u76f8\u540c\u7684\u03b22<\/sub>\u5fae\u7403\u86cb\u767d\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u8bb8\u591aHLA\u5206\u5b50\u83b7\u5f97\u7684DNA\u548c\u86cb\u767d\u8d28\u5e8f\u5217\u8868\u660e\u5b83\u4eec\u5728\u7ed3\u6784\u4e0a\u662f\u540c\u6e90\u7684\uff0c\u4e5f\u5c31\u662f\u8bf4\u5b83\u4eec\u7684\u5e8f\u5217\u975e\u5e38\u76f8\u4f3c\u3002\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539fA(HLA-A)\u5206\u5b50\u7684\u5e8f\u5217\u4e0e\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539fB(HLA-B)\u6216\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f(HLA-C)\u975e\u5e38\u76f8\u4f3c\u3002HLA-A\u3001HLA-B\u6216HLA-C\u7684\u7b49\u4f4d\u57fa\u56e0(\u66ff\u4ee3\u5f62\u5f0f)\u5f7c\u6b64\u66f4\u76f8\u4f3c\u3002\u56e0\u6b64\uff0c\u4e24\u4e2a\u4e0d\u540c\u7684HLA-A\u7b49\u4f4d\u57fa\u56e0\u53ef\u80fd\u6709\u5927\u7ea690%\u7684\u5e8f\u5217\u540c\u6e90\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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HLA-I\u7c7b\u57fa\u56e0\u5177\u6709\u5178\u578b\u7684\u7f16\u7801\u771f\u6838\u819c\u86cb\u767d\u57fa\u56e0\u7684\u5916\u663e\u5b50-\u5185\u542b\u5b50\u7ed3\u6784\u3002HLA-I\u7c7b\u57fa\u56e0\u4e0d\u4f1a\u50cf\u514d\u75ab\u7403\u86cb\u767d(Ig)\u6216TCR\u57fa\u56e0\u4e00\u6837\u53d1\u751f\u57fa\u56e0\u91cd\u6392\u3002\u4e2a\u4f53\u4ece\u7236\u6bcd\u90a3\u91cc\u7ee7\u627f\u4e86\u4e00\u7ec4HLA-I\u7c7b\u57fa\u56e0\uff0c\u4ed6\u4eec\u6700\u591a\u53ef\u4ee5\u8868\u8fbe6\u79cd\u4e0d\u540c\u7684I\u7c7bHLA-A\u3001-B\u6216-C\u5206\u5b50\u3002\u7136\u800c\uff0c\u6574\u4e2a\u7fa4\u4f53\u5177\u6709\u5e7f\u6cdb\u7684\u591a\u6001\u6027\uff0c\u5e76\u4e14\u5728\u4eba\u7c7b\u7fa4\u4f53\u4e2d\u5b58\u5728\u5927\u91cf\u7684\u7b49\u4f4d\u57fa\u56e0\uff0c\u4f8b\u5982\uff0c\u5728HLA-B\u4e0a\uff0c\u5927\u7ea6\u6709700\u4e2a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig8.4<\/span>\u8fd8\u663e\u793a\u4e86HLA I\u7c7b\u5206\u5b50\u7684\u4e09\u7ef4\u5e26\u72b6\u7ed3\u6784\u3002\u4ece\u7ed3\u6784\u53ef\u4ee5\u770b\u51fa\uff0c\u7528\u4e8e\u7ed3\u5408\u591a\u80bd(\u6297\u539f)\u7684\u5206\u5b50\u4e2d\u5f88\u660e\u663e\u5b58\u5728\u4e00\u4e2a\u7ed3\u5408\u69fd\u3002\u8fd9\u79cd\u7ed3\u5408\u69fd\u5728I\u7c7b\u5206\u5b50\u4e2d\u5b8c\u5168\u7531\u03b1\u94fe\u5f62\u6210\u3002\u6784\u6210\u51f9\u69fd\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u662f\u591a\u6001\u6027\u5f62\u6210\u7684\u4e3b\u8981\u4f4d\u70b9\u3002\u5373\u4e0d\u540c\u7684HLA-A\u7b49\u4f4d\u57fa\u56e0\u5728\u6297\u539f\u7ed3\u5408\u69fd\u4e2d\u4ea7\u751f\u4e0d\u540c\u7684\u6c28\u57fa\u9178\uff0c\u56e0\u6b64\u5b83\u4eec\u53ef\u4ee5\u7ed3\u5408\u4e0d\u540c\u8303\u56f4\u7684\u6297\u539f\u80bd\u30023D\u7ed3\u6784\u4e5f\u663e\u793a\u51fa\u4e00\u4e2a\u03b2\u6298\u53e0\u677f\u5e73\u53f0\u6837\u7684\u7ed3\u6784\u6765\u652f\u6301\u03b1\u87ba\u65cb\u7ed3\u5408\u4f4d\u70b9(\u4e0eIg\u540c\u6e90)\u3002\u6297\u539f\u80bd\u5c31\u50cf\u201c\u70ed\u72d7\u5939\u9762\u5305\u201d\u4e00\u6837\uff0c\u53ef\u4ee5\u653e\u5728\u51f9\u69fd\u91cc\u3002I\u7c7b\u7ed3\u5408\u4f4d\u70b9\u7ea6\u542b\u67098~11\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u591a\u80bd\u3002\u4e0e\u67d0\u4e9b\u6c28\u57fa\u9178(\u951a\u5b9a\u6b8b\u57fa)\u5728\u7279\u5b9a\u4f4d\u7f6e\u7684\u5b58\u5728\u60c5\u51b5\u76f8\u6bd4\uff0c\u8fd9\u91cc\u7684\u80bd\u7684\u7cbe\u786e\u5e8f\u5217\u5e76\u4e0d\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 8.4<\/span> MHC I \u7c7b\u5206\u5b50\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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II \u7c7b\u5206\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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II\u7c7bMHC\u5206\u5b50\u662f\u975e\u5171\u4ef7\u7ed3\u5408\u7684\u8de8\u819c\u5f02\u4e8c\u805a\u4f53\uff0c\u5176\u4e2d\u4e24\u6761\u94fe\u90fd\u7f16\u7801\u5728MHC\u4e2d\u3002\u03b1\u94fe\u7684\u5206\u5b50\u91cf\u7ea6\u4e3a33,000\uff0c\u03b2\u94fe\u7684\u5206\u5b50\u91cf\u7ea6\u4e3a29,000(Fig<\/span>8.5<\/span>)\u3002\u4e24\u8005\u90fd\u662f\u591a\u6001\u8de8\u819c\u7cd6\u86cb\u767d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9\u4e8eI\u7c7b\u57fa\u56e0\uff0c\u6ca1\u6709\u8bc1\u636e\u8868\u660e\u8be5\u7c7b\u57fa\u56e0\u53ef\u4ee5\u901a\u8fc7\u57fa\u56e0\u91cd\u7ec4\u4ea7\u751f\u591a\u6837\u6027(\u591a\u6001\u6027)\uff0cII\u7c7b\u57fa\u56e0\u5177\u6709\u5178\u578b\u7684\u819c\u86cb\u767d\u5916\u663e\u5b50-\u5185\u542b\u5b50\u7ed3\u6784\uff0c\u4e0d\u5b58\u5728\u5bf9\u5e94Ig\u548cTCR\u7684\u53ef\u53d8\u533a\u548c\u6052\u5b9a\u533a\u57fa\u56e0\u7c07\u3002\u7136\u800c\uff0c\u5f53\u6bd4\u8f83II\u7c7b\u4f4d\u70b9\u4e0a\u8bb8\u591a\u7b49\u4f4d\u57fa\u56e0\u7684\u57fa\u56e0\u548c\u86cb\u767d\u8d28\u5e8f\u5217\u65f6\uff0c\u6709\u8bc1\u636e\u8868\u660e\u8be5\u533a\u57df\u5177\u6709\u7684\u591a\u6837\u6027\u6709\u5927\u6709\u5c0f\u3002\u8fd9\u4e9b\u591a\u6837\u6027\u533a\u57df\u88ab\u79f0\u4e3a\u591a\u6001\u533a\u57df\uff0c\u5b83\u4eec\u805a\u96c6\u5728\u6298\u53e0\u7684\u5206\u5b50\u4e2d\u5f62\u6210\u4e0e\u6297\u539f\u7ed3\u5408\u7684\u6c9f\u69fd\u3002\u5982Fig8.5<\/span>\u6240\u793a\uff0cII\u7c7b\u5206\u5b50\u7684\u4e09\u7ef4\u7ed3\u6784\u5177\u6709\u03b2\u6298\u53e0\u7684\u7247\u72b6\u5e73\u53f0\u7ed3\u6784\uff0c\u5176\u9876\u90e8\u662f\u7528\u4e8e\u7ed3\u5408\u80bd\u6bb5\u7684\u03b2\u87ba\u65cb\u7ed3\u5408\u4f4d\u70b9\u3002II\u7c7b\u5206\u5b50\u4e2d\u7684\u7ed3\u5408\u69fd\u662f\u7531\u03b1\u548c\u03b2\u94fe\u5171\u540c\u5f62\u6210\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 I\u7c7b\u548cII\u7c7b\u5206\u5b50\u7684\u6574\u4f53\u4e09\u7ef4\u7ed3\u6784\u4e0d\u540c\uff0c\u4f46\u4e24\u8005\u4e5f\u6709\u5f88\u660e\u663e\u7684\u76f8\u4f3c\u4e4b\u5904\u3002II\u7c7b\u5206\u5b50\u80bd\u7ed3\u5408\u4f4d\u70b9\u6bd4I\u7c7b\u66f4\u201c\u5f00\u653e\u201d\uff0c\u591a\u80bd\u66f4\u957f(30\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u6216\u66f4\u957f)\u53ef\u4ee5\u63d2\u5165\u8be5\u4f4d\u70b9\u5e76\u5728\u4e24\u7aef\u91cd\u53e0\u3002\u540c\u6837\uff0c\u5c31\u50cfMHC-I\u7c7b\u5206\u5b50\u4e00\u6837\uff0c\u6297\u539f\u80bd\u7684\u5e8f\u5217\u5e76\u4e0d\u9700\u8981\u5f88\u7cbe\u786e\uff0c\u91cd\u8981\u7684\u662f\u5b83\u5728\u67d0\u4e9b\u4f4d\u7f6e\u542b\u6709\u7279\u5b9a\u7684\u6b8b\u57fa\u3002\u56e0\u6b64\uff0c\u4efb\u4f55\u7ed9\u5b9a\u7684MHC\u5206\u5b50\u90fd\u53ef\u4ee5\u540c\u65f6\u5bb9\u7eb3\u5404\u79cd\u591a\u80bd\u3002\u6240\u4ee5\uff0c\u4efb\u4f55\u7ed9\u5b9a\u7684\u590d\u6742\u6297\u539f\uff0c\u5982\u75c5\u6bd2\uff0c\u90fd\u4e0d\u80fd\u88ab\u4e2a\u4f53\u4e2d\u81f3\u5c11\u4e00\u4e2aMHC\u5206\u5b50\u6709\u6548\u8bc6\u522b\u5e76\u7ed3\u5408\u7684\u6297\u539f\u80bd\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e5f\u662f\u53ef\u80fd\u5b58\u5728\u7684\u3002\u8fd9\u6837\u7684\u4e2a\u4f53\u88ab\u79f0\u4e3a\u5bf9\u8be5\u6297\u539f\u65e0\u5e94\u7b54\u8005\u6216\u4f4e\u5e94\u7b54\u8005\u3002\u56e0\u6b64\uff0c\u63a7\u5236\u673a\u4f53\u514d\u75ab\u5e94\u7b54\u4e5f\u662f\u4e0eMHC\u76f8\u5173\u7684\u9057\u4f20\u7279\u5f81\u4e4b\u4e00\uff0c\u56e0\u4e3aMHC\u5206\u5b50\u5177\u6709\u7ed3\u5408\u6297\u539f\u5e76\u5728\u542f\u52a8\u514d\u75ab\u5e94\u7b54\u524d\u5c06\u5176\u5448\u9012\u7ed9TCRs\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 8.5<\/span> MHC II \u7c7b\u5206\u5b50\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u6297\u539f\u8bc6\u522b\u7684\u9650\u5236\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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MHC\u5206\u5b50\u4e2d\u6297\u539f\u7ed3\u5408\u69fd\u7684\u53d1\u73b0\u6709\u52a9\u4e8e\u89e3\u91ca\u65e9\u5148\u53d1\u73b0\u7684MHC\u9650\u5236\u7684\u6982\u5ff5\u3002\u636e\u89c2\u5bdf\uff0cT\u7ec6\u80de\u5bf9MHC\u548c\u6297\u539f\u5177\u6709\u7279\u5f02\u6027\uff0cMHC\u5206\u5b50\u5fc5\u987b\u662f\u81ea\u8eab\u7684MHC\u3002\u800cB\u7ec6\u80de\u53d7\u4f53\u53ef\u76f4\u63a5\u8bc6\u522b\u6297\u539f\uff0cTCR\u53ea\u8bc6\u522b\u4e0e\u81ea\u8eabMHC\u76f8\u5173\u7684\u975e\u81ea\u8eab\u6297\u539f\uff0c\u4e5f\u5c31\u662f\u8bf4\u6709\u4e00\u4e2a\u53cc\u91cd\u8bc6\u522b\u7684\u8fc7\u7a0b\u3002T\u7ec6\u80de\u5fc5\u987b\u8bc6\u522b\u5916\u6765\u6297\u539f\u548c\u81ea\u8eabMHC\u3002MHC\u65e2\u662f\u975e\u81ea\u8eab\u591a\u80bd\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u53c8\u662fTCR\u7684\u914d\u4f53\u3002TCR\u8bc6\u522b\u7684\u6297\u539f\u80bd\u662f\u5982\u4f55\u4ece\u590d\u6742\u7684\u975e\u81ea\u8eab\u6297\u539f(\u5982\u75c5\u6bd2)\u4e2d\u83b7\u5f97\u7684\uff0c\u4ee5\u53ca\u5b83\u4eec\u662f\u5982\u4f55\u4e0eMHC\u5206\u5b50\u7ed3\u5408\u7684\uff0c\u8fd9\u662f\u7b2c10\u7ae0<\/span>\u7684\u4e3b\u9898\u3002Table 8.1<\/span>\u5c06\u8fd9\u4e24\u79cd\u7c7b\u578b\u7684MHC\u53d7\u4f53\u4e0eT\u7ec6\u80de\u548cB\u7ec6\u80de\u53d7\u4f53\u8fdb\u884c\u4e86\u5bf9\u6bd4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 8.6<\/span> T\u7ec6\u80de\u5bf9\u6297\u539f\u7684\u8bc6\u522b\u53d7\u5230 MHC \u7684\u9650\u5236<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 8.1<\/span>\u6297\u539f\u8bc6\u522b\u5206\u5b50\u57fa\u56e0\u7684\u7ec4\u7ec7<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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MHC-\u6297\u539f-T\u7ec6\u80de<\/strong><\/span>\u53d7\u4f53<\/strong>\u590d\u5408\u4f53\u6a21\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Fig8.7<\/span>\u663e\u793a\u4e86\u6d89\u53caMHC-I\u7c7b\u5206\u5b50\u3001\u975e\u81ea\u8eab\u591a\u80bd\u6297\u539f\u548cTCR\u7684\u8bc6\u522b\u590d\u5408\u4f53\u7684\u793a\u610f\u56fe\u3002TCR\u53ef\u4ee5\u63a5\u89e6\u6765\u81eaMHC-I\u7c7b\u5206\u5b50\u4ee5\u53ca\u6297\u539f\u80bd\u4e2d\u7684\u6c28\u57fa\u9178\u3002\u6297\u539f\u80bd\u4e2d\u67d0\u4e9b\u6c28\u57fa\u9178\u4e0eMHC\u5206\u5b50\u4e2d\u7684\u6c28\u57fa\u9178\u5728\u591a\u80bd\u7ed3\u5408\u69fd\u4e2d\u7ed3\u5408\uff0c\u800c\u5176\u4ed6\u591a\u80bd\u6297\u539f\u6c28\u57fa\u9178\u4eceMHC\u69fd\u4e2d\u4f38\u51fa\u5e76\u4e0eTCR\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80f8\u817a\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u9009\u62e9\u7684TCRs\u4f9d\u8d56\u4e8e\u4e0eMHC\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4e5f\u5c31\u662f\u8bf4T\u7ec6\u80de\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u201c\u8ba4\u8bc6\u201d\u80f8\u817a\u4e2d\u7684\u81ea\u8eabMHC\uff0c\u800c\u90a3\u4e9b\u4e0d\u80fd\u7ed3\u5408\u81ea\u8eabMHC\u5206\u5b50\u7684TCR\u5c06\u88ab\u6d88\u9664\u6216\u4f7f\u5176\u53d8\u5f97\u65e0\u529b(\u5373\u65e0\u53cd\u5e94\uff1b\u89c1\u7b2c15\u7ae0<\/span>)\u3002\u8fd9\u4e5f\u6709\u52a9\u4e8e\u89e3\u91caMHC\u9650\u5236\u73b0\u8c61\uff0c\u5373T\u7ec6\u80de\u53d7\u4f53\u81ea\u8eabMHC\u7279\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 8.7<\/span> MHC-\u6297\u539f-T\u7ec6\u80de\u53d7\u4f53(TCR)\u590d\u5408\u4f53\u7684\u7ed3\u6784<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\u591a\u6001\u6027\u7684\u7fa4\u4f53\u4f18\u52bf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u591a\u4e2a\u4e0d\u540c\u7684HLA-I\u548cII\u7c7b\u57fa\u56e0\u7684\u5b58\u5728\u610f\u5473\u7740\u6709\u8bb8\u591a\u4e0d\u540c\u7684\u6297\u539f\u80bd\u7ed3\u5408\u5206\u5b50\u53ef\u5c06\u6297\u539f\u5448\u9012\u7ed9T\u7ec6\u80de\u3002\u8fd9\u4f3c\u4e4e\u5bf9\u4e2a\u4f53\u548c\u6574\u4e2a\u7fa4\u4f53\u90fd\u6709\u9009\u62e9\u6027\u4f18\u52bf\u3002\u6742\u5408\u5b50\u6bd4\u7eaf\u5408\u5b50\u80fd\u4ea7\u751f\u66f4\u591a\u4e0d\u540c\u7684\u75c5\u539f\u4f53\u6765\u6e90\u7684\u591a\u80bd\u3002HLA I\u7c7b\u7eaf\u5408\u5b50\u5df2\u88ab\u8bc1\u660e\u662fHIV\/AIDS\u7684\u4e0d\u5229\u56e0\u7d20(Box3.1<\/span>)\u3002\u6709\u8bc1\u636e\u8868\u660e\uff0cHLA II\u7c7b\u57fa\u56e0\u7eaf\u5408\u6027\u589e\u52a0\u4e86\u4e59\u809d\u75c5\u6bd2\u6301\u7eed\u611f\u67d3\u7684\u98ce\u9669\u3002\u5f53\u6d41\u884c\u75c5\u5728\u4eba\u7fa4\u4e2d\u8513\u5ef6\u65f6\uff0c\u62e5\u6709\u975e\u5e38\u7f55\u89c1\u7684HLA\u7b49\u4f4d\u57fa\u56e0\u4e5f\u53ef\u80fd\u662f\u6709\u5229\u7684\u3002\u56e0\u6b64\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cMHC\u7684\u591a\u6001\u6027\u786e\u5b9e\u53ef\u80fd\u5728\u5e94\u5bf9\u75c5\u539f\u4f53\u611f\u67d3\u65b9\u9762\u6709\u4e00\u5b9a\u4f18\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u75be\u75c5\u76f8\u5173\u6027<\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

\u8bb8\u591a\u4eba\u7c7b\u75be\u75c5\u4f3c\u4e4e\u4e0e\u67d0\u4e9bHLA\u7b49\u4f4d\u57fa\u56e0\u6709\u5173\u3002\u8fd9\u4e9b\u75be\u75c5\u901a\u5e38\u662f\u708e\u75c7\u6216\u81ea\u8eab\u514d\u75ab\u75c5\u3002\u5e7f\u6cdb\u5bb6\u65cf\u6027HLA\u5206\u578b\u4e0e\u67d0\u4e9bHLA\u7b49\u4f4d\u57fa\u56e0\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u76f8\u5173\u6027\uff0c\u4f8b\u5982\uff0c\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u5173\u8282\u75c5\u4e0eHLA-B27\u7b49\u4f4d\u57fa\u56e0\u9ad8\u5ea6\u76f8\u5173(Box8.3<\/span>)\u3002\u53e6\u4e00\u79cd\u4e0eHLA\u5bc6\u5207\u76f8\u5173\u7684\u75be\u75c5\u662f\u80f0\u5c9b\u7d20\u4f9d\u8d56\u578b\u7cd6\u5c3f\u75c5(IDDM)\u4e0e\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539fDQ2(HLADQ2)\u3002\u9ad8\u8fbe75%\u7684IDDM\u60a3\u8005\u60a3\u6709DQ2\u3002Table8.2<\/span>\u4e2d\u5217\u51fa\u4e86\u5176\u4ed6\u4e00\u4e9b\u9ad8\u76f8\u5173\u6027\u75be\u75c5\u3002\u8fd9\u4e9b\u89c2\u5bdf\u7ed3\u679c\u4ecd\u6709\u5f85\u5145\u5206\u89e3\u91ca\u3002\u5b83\u4eec\u53ef\u80fd\u4e0eMHC\u5206\u5b50\u5728\u7ed3\u5408\u591a\u80bd\u5448\u9012\u7ed9T\u7ec6\u80de\u7684\u4f5c\u7528\u6709\u5173\uff0c\u4e5f\u53ef\u80fd\u662f\u53e6\u4e00\u4e2a\u4e0eHLA\u76f8\u5173\u7684\u57fa\u56e0\u5bfc\u81f4\u7684\u7ed3\u679c\u3002\u5728\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u4e2d\u4e0e\u8865\u4f53\u57fa\u56e0\u76f8\u5173(III\u7c7bMHC\uff0c\u53e6\u89c1\u7b2c28\u7ae0<\/span>\u548c\u7b2c30\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 8.2 <\/span>\u5404\u79cd\u75be\u75c5\u4e0eHLA\u7b49\u4f4d\u57fa\u56e0\u7684\u76f8\u5173\u6027<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

BOX 8.1  <\/span>\u79fb\u690d\u6297\u539f\u4e0e\u6392\u65a5\u53cd\u5e94<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

MHC\u7f16\u7801\u57fa\u56e0\u7684\u4ea7\u7269\u6700\u521d\u88ab\u68c0\u6d4b\u4e3a\u79fb\u690d\u6297\u539f\uff0c\u5f53\u7ec4\u7ec7\u4f5c\u4e3a\u79fb\u690d\u7269\u5728\u4e2a\u4f53\u4e4b\u95f4\u4ea4\u6362\u65f6\u88ab\u8bc6\u522b\u4e3a\u975e\u81ea\u6211\u7684\u6297\u539f(\u5982\u80be\u79fb\u690d)\u3002\u79fb\u690d\u6297\u539f\u662f\u4e0d\u540c\u4e2a\u4f53\u95f4\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u7684\u4e3b\u8981\u539f\u56e0(\u7b2c34\u7ae0<\/span>)\u3002\u5982Fig8.8<\/span>\u6240\u793a\uff0c\u57fa\u56e0\u76f8\u540c(\u540c\u57fa\u56e0)\u7684\u4e2a\u4f53\u4e4b\u95f4\u79fb\u690d\u6210\u529f\u3002\u5982\u679c\u6ca1\u6709\u5176\u4ed6\u5e72\u9884\u63aa\u65bd\uff0c\u6bd4\u5982\u514d\u75ab\u6291\u5236\u836f\u7269(\u5982\u73af\u5b62\u7d20)\uff0c\u6240\u6709\u5176\u4ed6\u836f\u7269\u6700\u7ec8\u90fd\u4f1a\u5931\u6548\u3002\u8fd9\u662f\u79fb\u690d\u7684\u57fa\u672c\u6cd5\u5219\u3002\u79fb\u690d\u6297\u539f\u4e3b\u8981\u662f\u7f16\u7801\u5728MHC\u4e2d\u7684\u5206\u5b50\uff0c\u5b83\u4eec\u5e76\u4e0d\u4ec5\u4ec5\u662f\u4e3a\u4e86\u963b\u6320\u79fb\u690d\u5916\u79d1\u533b\u751f\u7684\u52aa\u529b\u800c\u5b58\u5728,\u540c\u65f6\u4e5f\u662f\u91cd\u8981\u7684\u6297\u539f\u8bc6\u522b\u5206\u5b50\uff0c\u53ef\u4ee5\u201c\u5c55\u793a\u201d\u6297\u539f\uff0c\u4f9bT\u7ec6\u80de\u201c\u68c0\u89c6\u201d\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n

Fig 8.8  <\/span>\u79fb\u690d\u6cd5\u5219<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

BOX 8.2 <\/span>\u8c01\u662f\u51f6\u624b\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u4e00\u540d28\u5c81\u7684\u5973\u5b50\u5728\u5bb6\u4e2d\u88ab\u8c0b\u6740\u3002\u6cd5\u533b\u79d1\u5b66\u5c0f\u7ec4\u53d1\u73b0\u4e86\u5979\u88ab\u52d2\u6b7b\u7684\u8bc1\u636e\uff0c\u5979\u7684\u7537\u670b\u53cb\u662f\u4e3b\u8981\u5acc\u7591\u4eba\u3002\u7136\u800c\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u5979\u7684\u6307\u7532\u4e0b\u53d1\u73b0\u4e86\u4e00\u4e9b\u76ae\u80a4\uff0c\u5e76\u5728\u5979\u7684\u624b\u4e2d\u53d1\u73b0\u4e86\u516d\u6839\u5934\u53d1\u3002\u6709\u8db3\u591f\u7684\u7ec4\u7ec7\u63d0\u53d6DNA\uff0c\u53ef\u4ee5\u7528\u6765\u68c0\u67e5\u76ae\u80a4\u548c\u5934\u53d1\u4e2d\u7684HLA\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u663e\u793a\u4ee5\u4e0bHLA\u7c7b\u578b\uff1aA3A1\u3001B7B8\u3001C7C3\u3001DR5\u3001DR3\u3002\u5979\u7537\u670b\u53cb\u7684HLA\u7c7b\u578b\u662fA3A8\uff0cB7B27\uff0cC7C4\uff0cDR7\uff0cDR7\u3002\u9a8c\u5c38\u65f6\u53d1\u73b0\u7684\u7ec4\u7ec7\u4e0d\u53ef\u80fd\u6765\u81ea\u53d7\u5bb3\u8005\u7684\u7537\u670b\u53cb\uff0c\u80af\u5b9a\u6709\u5176\u4ed6\u4eba\u53c2\u4e0e\u5176\u4e2d\u3002<\/p>\n

\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0cHLA\u5206\u578b\u88ab\u7528\u6765\u6392\u9664\u5acc\u7591\u4eba\u3002\u5373\u4f7f\u5728\u7ec4\u7ec7\u4e2d\u53d1\u73b0\u7684HLA\u7c7b\u578b\u4e0e\u7537\u53cb\u78b0\u5de7\u662f\u76f8\u540c\u7684\uff0c\u8fd9\u4e5f\u4e0d\u80fd\u4f5c\u4e3a\u8bc1\u636e\u6765\u63a8\u65ad\u4ed6\u5728\u8c0b\u6740\u65f6\u4ed6\u5c31\u5728\u73b0\u573a\u3002\u51f6\u624b\u548c\u7537\u53cb\u6709\u76f8\u540c\u7684HLA\u8840\u578b\u7684\u53ef\u80fd\u6027\u5f88\u5c0f\u3002<\/p>\n

HLA\u5206\u578b\u4e5f\u53ef\u4ee5\u7528\u4e8e\u4eb2\u5b50\u9274\u5b9a\uff0c\u4ee5\u786e\u5b9a\u5b69\u5b50\u7684\u7236\u4eb2\u662f\u8c01\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5b9e\u9a8c\u5ba4\u9700\u8981\u9996\u5148\u5bf9\u6bcd\u5a74\u8fdb\u884cHLA\u5206\u578b\u3002\u4e00\u79cd\u5355\u500d\u578b\u9057\u4f20\u81ea\u6bcd\u4eb2\uff0c\u53e6\u4e00\u79cd\u5355\u500d\u578b\u9057\u4f20\u81ea\u7236\u4eb2\u3002\u540c\u6837\u7684\u903b\u8f91\u4e5f\u9002\u7528\u4e8e\u8fd9\u4e2a\u573a\u666f\uff0c\u5c31\u50cf\u4e0a\u9762\u7684\u4e00\u4e2a\u6740\u4eba\u72af\u4e00\u6837\uff1a\u5982\u679c\u5a74\u513f\u7684\u7236\u4eb2\u7684\u5355\u500d\u578b\u4e0d\u540c\u4e8e\u201c\u5acc\u7591\u4eba\u201d\u7236\u4eb2\u62e5\u6709\u7684\u4efb\u4f55\u4e00\u4e2a\u5355\u500d\u578b\uff0c\u4ed6\u5c31\u4e0d\u53ef\u80fd\u662f\u201c\u72af\u7f6a\u8005\u201d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

BOX 8.3 <\/span>HLA-B27\u4e0e\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u76f8\u5173\u6027<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u9057\u4f20\u548c\u73af\u5883\u56e0\u7d20\u90fd\u4f1a\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u5728\u4e0e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0\u4e2d\uff0c\u4e0eMHC\u57fa\u56e0\u7684\u76f8\u5173\u6027\u6700\u5f3a(\u89c1Table8.2<\/span>)\u3002HLA-B27\u548c\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u4e4b\u95f4\u7684\u5173\u8054\u6700\u660e\u663e\u3002\u60a3\u8005\u4f1a\u51fa\u73b0\u810a\u690e\u5173\u8282\u53d1\u708e\u3002\u6700\u521d\u53ef\u80fd\u51fa\u73b0\u4e0b\u80cc\u90e8\u75bc\u75db\u548c\u50f5\u786c\uff0c\u5bfc\u81f4\u884c\u8d70\u56f0\u96be\u3002\u6700\u7ec8\u810a\u690e\u53ef\u80fd\u4f1a\u5f2f\u66f2\u53d7\u9650\u3002\u6d88\u708e\u836f\u901a\u5e38\u80fd\u51cf\u8f7b\u75be\u75c5\u75c7\u72b6\u3002\u643a\u5e26HLA-B27\u7684\u4e2a\u4f53\u60a3\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u53ef\u80fd\u6027\u5927\u7ea6\u662f\u4eba\u7fa4\u4e2d\u5176\u4ed6\u4e2a\u4f53\u768490\u500d\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8be5\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e0eHLA-B27\u76f8\u5173\u7684\u57fa\u7840\u3002\u73af\u5883\u56e0\u7d20\u6709\u5f88\u591a\uff0c\u4e5f\u53ef\u80fd\u662f\u611f\u67d3\uff0c\u611f\u67d3\u5bf9\u8fd9\u79cd\u75be\u75c5\u7684\u5f71\u54cd\u4e0eHLA\u5bf9\u8fd9\u79cd\u75be\u75c5\u7684\u5f71\u54cd\u4e00\u6837\u5927\u3002\u4f8b\u5982\uff0c\u53ea\u6709\u4e00\u5c0f\u90e8\u5206\u8868\u8fbeHLA-B27\u7684\u4eba\u4f1a\u53d1\u5c55\u6210\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n

<\/section>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |  \u738b\u60e0\u742a \u674e\u6f84\u7199 \u90d1\u68a6\u6021<\/span><\/span><\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u949f\u96ea\u83b9<\/span><\/span><\/section>\n
\u5ba1\u6838 |  \u738b\u5764 \u5b8b\u4e50<\/span><\/section>\n

<\/section>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a><\/span>
<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

\n
\n
\n
\n
BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/section>\n
\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a><\/span><\/section>\n
\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/span><\/a>
<\/section>\n
PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/span><\/a>
<\/section>\n
\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/span><\/a>
<\/section>\n
\u5982\u4f55\u6d4b\u91cfWestern Blot\u6761\u5e26\u7070\u5ea6\u503c\uff1f(GelPro\u8f6f\u4ef6\u4f7f\u7528\u65b9\u6cd5)<\/span><\/a>
<\/section>\n

\u5b9e\u9a8c\u4e2d\u5982\u4f55\u6311\u9009\u5230\u4e00\u652f\u597d\u7528\u7684\u6297\u4f53\uff1f<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n
<\/mpprofile><\/section>\n

\u70b9\u51fb\u4e0a\u65b9\u540d\u7247\u5173\u6ce8\u672c\u53f7\u83b7\u53d6\u540e\u7eed\u66f4\u591a\u7cbe\u5f69\u5185\u5bb9~<\/span><\/p>\n


<\/span><\/p>\n


<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u300c\u4e09\u8fde\u300d\uff01<\/span>
<\/section>\n

<\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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