{"id":1878,"date":"2021-05-19T23:24:53","date_gmt":"2021-05-19T15:24:53","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2021\/05\/19\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac14%e7%ab%a0%ef%bc%9ab%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2\/"},"modified":"2021-05-19T23:24:53","modified_gmt":"2021-05-19T15:24:53","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac14%e7%ab%a0%ef%bc%9ab%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2021\/05\/19\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac14%e7%ab%a0%ef%bc%9ab%e7%bb%86%e8%83%9e%e7%9a%84%e5%8f%91%e8%82%b2\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2"},"content":{"rendered":"
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\u6b63\u5982\u7b2c6\u7ae0<\/span>\u548c\u7b2c11\u7ae0<\/span>\u6240\u8ba8\u8bba\u7684\u90a3\u6837\uff0cB\u7ec6\u80de\u8868\u9762\u7684\u819c\u7ed3\u5408\u6297\u4f53\u5206\u5b50\u6784\u6210\u8d1f\u8d23\u8bc6\u522b\u6297\u539f\u7684B\u7ec6\u80de\u53d7\u4f53(BCR)\u7684\u5173\u952e\u90e8\u5206\u3002\u6297\u539f\u7279\u5f02\u6027BCR\u7ecf\u8fc7\u4e00\u7cfb\u5217\u7684\u53d1\u80b2\u8fc7\u7a0b\u624d\u80fd\u6700\u7ec8\u8868\u8fbe\uff0c\u8868\u8fbe\u591a\u79cdBCR\u7684B\u6dcb\u5df4\u7ec6\u80de(\u5c1a\u672a\u88ab\u9009\u62e9)\u5728\u9aa8\u9ad3\u4e2d\u4e0d\u65ad\u4ea7\u751f\u3002\u5728\u53d1\u80b2\u6210\u719f\u4e4b\u524d\uff0c\u53d1\u80b2\u4e2d\u7684B\u7ec6\u80de\u4f1a\u7ecf\u5386\u4e00\u4e2a\u88ab\u79f0\u4e3a\u9634\u6027\u9009\u62e9\u7684\u9009\u62e9\u8fc7\u7a0b\uff0c\u4ee5\u786e\u4fdd\u5b83\u4eec\u7684\u6297\u539f\u53d7\u4f53\u4e0d\u8bc6\u522b\u81ea\u8eab\u6297\u539f\uff0c\u5426\u5219\u81ea\u8eab\u53cd\u5e94\u6027\u53ef\u80fd\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u53d1\u751f(\u7b2c28\u7ae0<\/span>)\u3002\u5728\u9634\u6027\u9009\u62e9\u4e2d\u5e78\u5b58\u4e0b\u6765\u7684B\u7ec6\u80de\u5206\u6563\u5230\u5916\u5468\u6dcb\u5df4\u5668\u5b98(\u7b2c13\u7ae0<\/span>)\uff0c\u5728\u90a3\u91cc\u5b83\u4eec\u53ef\u80fd\u4f1a\u9047\u5230\u5177\u6709\u7279\u5f02\u6027\u7684\u5916\u6765\u6297\u539f\uff0c\u7136\u540e\u88ab\u6fc0\u6d3b\uff0c\u6700\u7ec8\u5206\u5316\u4e3a\u53ef\u4ee5\u4ea7\u751f\u6297\u4f53\u7684\u7ec6\u80de\u3002\u800c\u6ca1\u6709\u9047\u5230\u5408\u9002\u6297\u539f\u7684B\u7ec6\u80de\u4f1a\u5728\u51e0\u5468\u5185\u6b7b\u4ea1\u3002\u672c\u7ae0\u548c\u4e0a\u56fe\u8bb2\u8ff0\u4e86B\u7ec6\u80de\u4ece\u9020\u8840\u5e72\u7ec6\u80de\u5230\u5e38\u89c4\u6210\u719fB\u7ec6\u80de\u7684\u53d1\u80b2\u9636\u6bb5\u3002\u5728\u8fd9\u4e00\u7ae0\u7684\u6700\u540e\uff0c\u63cf\u8ff0\u4e86\u4e24\u79cd\u975e\u5e38\u89c4\u7684B\u7ec6\u80de\u7fa4\u4f53\uff0c\u5373\u975eT\u7ec6\u80de\u4f9d\u8d56\u6027\u7684B\u7ec6\u80de\u548cB1\u578bB\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u6dcb\u5df4\u7ec6\u80de\u7684\u65e9\u671f\u53d1\u80b2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u6765\u6e90\u4e8e\u7531\u9020\u8840\u5e72\u7ec6\u80de\u5206\u5316\u5f62\u6210\u7684\u6dcb\u5df4\u7956\u7ec6\u80de(\u7b2c12\u7ae0<\/span>)\u3002\u4eba\u7684\u4e00\u751f\u90fd\u4f1a\u4ea7\u751fB\u7ec6\u80de\uff0c\u4f46B\u7ec6\u80de\u7684\u5206\u5316\u9996\u5148\u53d1\u751f\u5728\u80ce\u513f\u809d\u810f\uff0c\u51fa\u751f\u540e\u4e0d\u4e45\u4fbf\u8f6c\u79fb\u5230\u9aa8\u9ad3(\u7b2c12\u7ae0\u548c\u7b2c13\u7ae0<\/span>)\u3002\u5728\u6210\u4eba\u9aa8\u9ad3\u4e2d\uff0cB\u7ec6\u80de\u7684\u53d1\u80b2\u6210\u719f\u9014\u5f84\u5448\u653e\u5c04\u72b6\uff0c\u5176\u4e2d\u6700\u4e0d\u6210\u719f\u7684\u7ec6\u80de\u9760\u8fd1\u9aa8\u5185\u819c\u8868\u9762\uff0c\u800c\u8f83\u6210\u719f\u7684\u7ec6\u80de\u96c6\u4e2d\u5728\u9aa8\u9ad3\u4e2d\u592e\u7a7a\u95f4\u3002\u672a\u6210\u719f\u7684B\u7ec6\u80de\u901a\u8fc7\u8840\u7aa6\u6d41\u51fa\u9aa8\u9ad3\uff0c\u5e76\u8fc1\u79fb\u5230\u5916\u5468\uff08\u901a\u5e38\u662f\u813e\u810f\u6216\u6dcb\u5df4\u7ed3\uff09\u3002\u5b83\u4eec\u5728\u9aa8\u9ad3\u4e2d\u7684\u53d1\u80b2\u4f9d\u8d56\u4e8e\u9aa8\u9ad3\u57fa\u8d28\u7ec6\u80de\u63d0\u4f9b\u7684\u5404\u79cd\u751f\u957f\u56e0\u5b50(\u7b2c12\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u6700\u65e9\u7684\u7ec4\u7ec6\u80de–\u9020\u8840\u5e72\u7ec6\u80de\u5f00\u59cb\uff0cB\u7ec6\u80de\u7684\u5206\u5316\u9014\u5f84\u53ef\u7ec6\u5206\u4e3a\u51e0\u4e2a\u53d1\u80b2\u9636\u6bb5\u3002\u8fd9\u4e9b\u9636\u6bb5\u662f\u7531\u514d\u75ab\u7403\u86cb\u767d(Ig)\u91cd\u94fe\u548c\u8f7b\u94fe\u57fa\u56e0\u7684\u91cd\u6392\u4ee5\u53ca\u7ec6\u80de\u8868\u9762\u7684\u5206\u5316\u7279\u5f02\u6027\u5206\u5b50\u7684\u8868\u8fbe\u6765\u5b9a\u4e49\u7684\uff0c\u5982Table14.1<\/span>\u6240\u793a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TABLE14.1<\/span>\u5206\u5316\u7279\u5f02\u6027\u5206\u5b50<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u65e9\u786e\u5b9a\u7684B\u7cfb\u7ec6\u80de\u88ab\u79f0\u4e3a\u539fB\u7ec6\u80de(pro-B cell)\u3002\u8fd9\u79cd\u7ec6\u80de\u662f\u901a\u8fc7B\u7cfb\u7279\u6709\u7684\u8868\u9762\u6807\u5fd7\u7269\u6765\u8bc6\u522b\u7684\uff0c\u4f8b\u5982CD19\uff08\u5171\u53d7\u4f53\u590d\u5408\u4f53\u7684\u4e00\u90e8\u5206\uff09(\u7b2c11\u7ae0<\/span>)\u3002\u91cd\u7ec4\u6fc0\u6d3b\u57fa\u56e0(RAG)\u5728pro-B\u7ec6\u80de\u4e2d\u8f83\u6d3b\u8dc3\uff0cIg\u91cd\u94fe\u57fa\u56e0\u7fa4\u4e2d\u7f16\u7801\u53ef\u53d8\u533a\u7684V\u57fa\u56e0\u7247\u6bb5\uff08VH\uff09\u3001D\u57fa\u56e0\u7247\u6bb5\uff08DH\uff09\u548cJ\u57fa\u56e0\u7247\u6bb5\uff08JH\uff09\u8fdb\u884c\u91cd\u6392\uff0c\u5e76\u4ea7\u751f\u91cd\u94fe\u3002\u5728\u8fd9\u4e9b\u7ec6\u80de\u4e2d, \u672b\u7aef\u8131\u6c27\u6838\u82f7\u9178\u8f6c\u79fb\u9176(TDT)\u4e5f\u662f\u6d3b\u8dc3\u7684\uff0c\u5b83\u53ef\u589e\u52a0\u8fde\u63a5\u7684\u591a\u6837\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u65e6\u8868\u8fbe\u4e86\u00b5\u91cd\u94fe\uff0c\u8be5\u7ec6\u80de\u5c31\u6210\u4e3a\u524dB\u7ec6\u80de\uff08pre-B\u7ec6\u80de\uff09(\u89c1\u7b2c6\u7ae0<\/span>)\u3002\u00b5\u91cd\u94fe(\u00b5H)\u4e0e\u524dB\u7ec6\u80de\u53d7\u4f53(\u03c8L)\u548c\u00b5H\u94fe(\u7b2c11\u7ae0<\/span>)\u4e00\u8d77\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff0c\u5f62\u6210\u524dB\u7ec6\u80de\u53d7\u4f53(pre-BCR)\u7684\u53d7\u4f53\u590d\u5408\u4f53\u3002pre-BCR\u5728pre-B\u7ec6\u80de\u7684\u589e\u6b96\u548c\u4fc3\u8fdb\u5176\u8fdb\u4e00\u6b65\u53d1\u80b2\u7684\u4fe1\u53f7\u4f20\u5bfc\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u589e\u6b96\u4fc3\u8fdb\u4e86\u4e0b\u4e00\u4e2a\u4e3b\u8981\u9636\u6bb5\u2014\u2014\u665a\u671fpre-B\u7ec6\u80de\u7684\u8fdb\u4e00\u6b65\u53d1\u80b2\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728pre-B\u7ec6\u80de\u9636\u6bb5\uff0cV(D)J\u91cd\u7ec4\u9176\u673a\u5236\u542f\u52a8\u8f7b\u94fe\u57fa\u56e0\u91cd\u6392\u3002\u7ec6\u80de\u9996\u5148\u91cd\u7ec4\u03ba\u8f7b\u94fe\uff0c\u5982\u679c\u91cd\u7ec4\u4e0d\u6210\u529f\uff0c\u5b83\u5c06\u4ea7\u751f\u03bb\u8f7b\u94fe\u3002\u5f53\u6210\u5bf9\u7684\u8f7b\u94fe\u548c\u91cd\u94fe\u591a\u80bd\u5f62\u6210\u5b8c\u6574\u7684IgM\u5206\u5b50\uff08BCR\uff09\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u65f6\uff0c\u8868\u660e\u7ec6\u80de\u5df2\u53d1\u80b2\u6210\u672a\u6210\u719fB\u7ec6\u80de(Immature B)\uff0cRAG\u548cTDT\u9176\u5219\u4e0d\u4f1a\u518d\u8fdb\u884c\u8f6c\u5f55(Fig14.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 14.1<\/span> \u5728\u9aa8\u9ad3\u4e2d\u4ea7\u751f\u8868\u8fbeBCR\u7684\u672a\u6210\u719fB\u7ec6\u80de<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u7ecf\u5386\u4e0a\u8ff0\u6210\u719f\u8fc7\u7a0b\u7684\u540c\u65f6\u4e5f\u5728\u5206\u88c2\u548c\u589e\u6b96\u3002\u6700\u7ec8\u53ef\u4ee5\u4ea7\u751f\u5927\u91cf\u7684B\u7ec6\u80de\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u91cd\u7ec4\u4e0d\u80fd\u6210\u529f\u8868\u8fbepre-BCR\u6216BCR\u5bf9\u7ec6\u80de\u6765\u8bf4\u662f\u81f4\u547d\u7684\uff0c\u8fd9\u786e\u4fdd\u4e86\u53ea\u6709BCR\u5b8c\u597d\u7684B\u7ec6\u80de\u624d\u80fd\u5728\u6210\u719f\u8fc7\u7a0b\u4e2d\u5b58\u6d3b\u4e0b\u6765\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u91cd\u7ec4\u5f62\u6210\u4e86\u53d7\u4f53\u591a\u6837\u6027\uff0c\u4f46\u5fc5\u7136\u4f1a\u4ea7\u751f\u4e00\u4e9b\u5177\u6709\u81ea\u8eab\u53cd\u5e94\u6027\u7684\u6297\u539f\u53d7\u4f53\u3002\u8fd9\u4e9b\u53d7\u4f53\u5f88\u53ef\u80fd\u4f1a\u8bc6\u522b\u4e00\u4e9b\u81ea\u8eab\u6297\u539f\uff0c\u8868\u8fbe\u8fd9\u4e9b\u53d7\u4f53\u7684\u7ec6\u80de\u9700\u8981\u88ab\u6740\u6b7b\u6216\u8005\u6291\u5236\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u9634\u6027\u9009\u62e9\u3002\u8fd9\u4e00\u9009\u62e9\u8fc7\u7a0b\u4f7f\u5f97\u672a\u6210\u719f\u7684B\u7ec6\u80de\u5728\u53d7\u5230\u81ea\u8eab\u6297\u539f\u7684\u523a\u6fc0\u65f6\u4e0d\u4f1a\u88ab\u6fc0\u6d3b\uff0c\u8fd9\u79cd\u60c5\u51b5\u88ab\u79f0\u4e3a\u8010\u53d7\u6027\u3002\u5728\u672c\u6587\u4e2d\uff0c\u81ea\u8eab\u6297\u539f\u662f\u6307\u9aa8\u9ad3\u4e2d\u5b58\u5728\u7684\u53ef\u4ee5\u88abBCR\u7ed3\u5408\u7684\u5927\u5206\u5b50\u3002\u8fd9\u4e9b\u5206\u5b50\u53ef\u80fd\u662f\u5b58\u5728\u4e8e\u5065\u5eb7\u7ec6\u80de\u8868\u9762\u7684\u5206\u5b50\uff0c\u4e5f\u53ef\u80fd\u662f\u4ee5\u6eb6\u6db2\u5f62\u5f0f\u5b58\u5728\u4e8e\u7ec6\u80de\u5916\u57fa\u8d28\u4e2d\u7684\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u8868\u9762\u4e30\u5bcc\u7684\u81ea\u8eab\u6297\u539f\u53ef\u4ee5\u5e7f\u6cdb\u5730\u4e0e\u672a\u6210\u719f\u7684BCR\u7ed3\u5408\uff0c\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\uff0c\u5bfc\u81f4\u80fd\u591f\u4e0e\u81ea\u8eab\u6297\u539f\u53cd\u5e94\u7684\u514b\u9686\u88ab\u6e05\u9664\u3002\u672a\u6210\u719f\u7684B\u7ec6\u80de\u5bf9\u5c0f\u4e14\u4e0d\u80fd\u6709\u6548\u7ed3\u5408\u672a\u6210\u719f\u7684BCR\u7684\u53ef\u6eb6\u6027\u86cb\u767d\u7684\u53cd\u5e94\u4e0d\u540c\u3002\u5f53\u672a\u6210\u719f\u7684B\u7ec6\u80de\u66b4\u9732\u5728\u9ad8\u5242\u91cf\u7684\u53ef\u6eb6\u6027\u6297\u539f\u4e0b\u65f6\uff0c\u4ea7\u751f\u53cd\u5e94\u7684B\u7ec6\u80de\u4f1a\u4e0b\u8c03IgM\u7684\u8868\u8fbe\uff0c\u968f\u540e\u5bf9\u6297\u539f\u523a\u6fc0\u4e0d\u4ea7\u751f\u5e94\u7b54\uff0c\u8fd9\u79cd\u60c5\u51b5\u88ab\u79f0\u4e3a\u5931\u80fd\u3002\u8fd9\u4e9bB\u7ec6\u80de\u4e0d\u4f1a\u88ab\u6740\u6b7b\uff0c\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u4ee5\u4ece\u5931\u80fd\u4e2d\u6062\u590d\u8fc7\u6765\u3002\u5728\u9634\u6027\u9009\u62e9\u4e2d\u5e78\u5b58\u4e0b\u6765\u7684B\u7ec6\u80de\u4f1a\u589e\u52a0\u7684IgM\u6c34\u5e73\uff0c\u5e76\u5f00<\/span>\u59cb\u8868\u8fbe\u819c\u7ed3\u5408\u578bIgD(Fig14.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 14.2 <\/span>\u9634\u6027\u9009\u62e9\u786e\u4fdd\u53ea\u5141\u8bb8\u4e0d\u8bc6\u522b\u81ea\u8eab\u6297\u539f\u7684\u672a\u6210\u719fB\u7ec6\u80de\u79bb\u5f00\u9aa8\u9ad3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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IgD\u5728\u91cd\u94fe\u8f6c\u5f55\u672c\u9009\u62e9\u6027\u526a\u63a5\u540e\u8868\u8fbe(\u7b2c6\u7ae0<\/span>)\u3002B\u7ec6\u80de\u7ecf\u8fc7\u8fd9\u4e00\u9636\u6bb5\u540e\u6210\u4e3a\u8868\u8fbe\u8868\u9762IgM\u548c\u8868\u9762IgD\u7684\u6210\u719fB\u7ec6\u80de\u3002\u4e00\u65e6B\u7ec6\u80de\u5728\u9aa8\u9ad3\u4e2d\u5b8c\u6210\u65e9\u671f\u6210\u719f\u9636\u6bb5\uff0c\u5b83\u5c31\u5f00\u59cb\u8fc1\u79fb\u5230\u5916\u5468\u6dcb\u5df4\u5668\u5b98\u4ee5\u5b8c\u6210\u5176\u53d1\u80b2\u3002\u5df2\u5b8c\u5168\u5b8c\u6210Ig\u57fa\u56e0\u91cd\u6392\u4f46\u8fd8\u6ca1\u9047\u5230\u975e\u81ea\u8eab\u6297\u539f\u7684B\u7ec6\u80de\u79f0\u4e3a\u521d\u59cbB\u7ec6\u80de(naive B cells)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6210\u719fB\u7ec6\u80de<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u4e3a\u5e76\u4e0d\u662f\u6240\u6709\u7684\u81ea\u8eab\u6297\u539f\u90fd\u5b58\u5728\u4e8e\u9aa8\u9ad3\u4e2d\uff0c\u8fdb\u5316\u673a\u5236\u53ef\u786e\u4fdd\u6210\u719f\u7684B\u7ec6\u80de\u7fa4\u5bf9\u5468\u56f4\u9047\u5230\u7684\u81ea\u8eab\u6297\u539f\u5177\u6709\u8010\u53d7\u6027\u3002\u6210\u719f\u7684B\u7ec6\u80de\u901a\u5e38\u9700\u8981T\u7ec6\u80de\u7684\u5e2e\u52a9\u624d\u80fd\u4ea7\u751f\u6297\u4f53\u3002\u5982\u679c\u6210\u719f\u7684B\u7ec6\u80de\u4e0e\u6297\u539f\u7ed3\u5408\uff0c\u800c\u8be5\u6297\u539f\u7684\u7279\u5f02\u6027T\u7ec6\u80de\u6ca1\u6709<\/span>\u63d0\u4f9bB\u7ec6\u80de\u5b8c\u5168\u6fc0\u6d3b\u6240\u9700\u7684\u4fe1\u53f7(\u7b2c11\u7ae0\u548c<\/span>\u7b2c16\u7ae0<\/span>)\uff0c\u90a3\u4e48\u8be5\u7ec6\u80de\u5c06\u88ab\u6e05\u9664\u6216\u5931\u80fd\u3002\u4e0e\u672a\u6210\u719f\u7684B\u7ec6\u80de\u4e00\u6837\uff0c\u53d7\u4f53\u7ed3\u5408\u53d6\u51b3\u4e8e\u6240\u9047\u5230\u7684\u6297\u539f\u3002\u591a\u4ef7\u6297\u539f\u901a\u5e38\u5f15\u8d77\u514b\u9686\u6e05\u9664\uff0c\u5355\u4ef7\u6297\u539f\u5219\u5f15\u8d77\u5931\u80fd(Fig14.3<\/span>)\u3002\u7136\u800c\uff0c\u6709\u4e00\u4e9bB\u7ec6\u80de\u5df2\u7ecf\u8fdb\u5316\u6210\u80fd\u591f\u5728\u6ca1\u6709T\u7ec6\u80de\u5e2e\u52a9\u7684\u60c5\u51b5\u4e0b\u5bf9\u591a\u4ef7\u591a\u7cd6\u6297\u539f\u4ea7\u751f\u7279\u5f02\u6027\u53cd\u5e94\uff1b\u8fd9\u4e9b\u4e0d\u4f9d\u8d56\u80f8\u817a(T\u7ec6\u80de\u975e\u4f9d\u8d56\u6027)\u7684B\u7ec6\u80de\u5c06\u5728\u672c\u7ae0\u540e\u9762\u8fdb\u884c\u8ba8\u8bba\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 14.3<\/span> \u751f\u53d1\u4e2d\u5fc3\uff1a\u521d\u59cbB\u7ec6\u80de\u8bc6\u522b\u6297\u539f\u5e76\u63a5\u53d7T\u7ec6\u80de\u7684\u5e2e\u52a9<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6d3b\u5316\u4e0e\u6297\u4f53\u4ea7\u751f<\/p>\n<\/section>\n

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\u5bf9\u7279\u5b9a\u6297\u539f\u505a\u51fa\u53cd\u5e94\u7684B\u7ec6\u80de\u901a\u5e38\u9700\u8981T\u7ec6\u80de\u7684\u5e2e\u52a9\uff0c\u5e76\u9700\u8981\u6ee4\u6ce1\u6811\u7a81\u72b6\u7ec6\u80de(FDCs)\u6765\u63d0\u5448\u6297\u539f\u3002\u6b63\u5982\u7b2c13\u7ae0\u6240\u8ff0<\/span><\/span>\uff0c\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u4e2d\u7684\u6ee4\u6ce1\u63d0\u4f9b\u4e86\u4e00\u4e2a\u73af\u5883\uff0c\u5728\u90a3\u91cc\u6297\u539f\u88ab\u96c6\u4e2d\u5e76\u5448\u9012\u7ed9\u521d\u59cbB\u7ec6\u80de\uff0c\u5e76\u4e14\u521d\u59cb B\u7ec6\u80de\u3001FDCs\u548cT\u7ec6\u80de\u53ef\u4ee5\u76f8\u4e92\u4f5c\u7528\u3002\u6bcf\u79cd\u7c7b\u578b\u7684\u6b21\u7ea7\u6dcb\u5df4\u7ec4\u7ec7\u53ef\u6355\u83b7\u4e0d\u540c\u6765\u6e90\u7684\u6297\u539f\uff1a\u5982\u813e\u810f\u6536\u96c6\u8840\u6db2\u6027\u6297\u539f\uff0c\u6dcb\u5df4\u7ed3\u6355\u83b7\u8fdb\u5165\u6dcb\u5df4\u7cfb\u7edf\u4e2d\u7684\u6297\u539f\u3001\u7c98\u819c\u76f8\u5173\u6dcb\u5df4\u7ec4\u7ec7(MALT)\uff0c\u5982\u80a0\u9053\u4e2d\u7684Peyer\u6591\u5757\u548c\u9f3b\u54bd\u4e2d\u7684\u6241\u6843\u4f53\/\u817a\u6837\u4f53\uff0c\u4ece\u5468\u56f4\u7684\u7c98\u819c\u4e0a\u76ae\u7ec6\u80de\u83b7\u5f97\u6297\u539f\u3002\u6210\u719f\u7684\u521d\u59cbB\u7ec6\u80de\u79bb\u5f00\u9aa8\u9ad3\u540e\u4f1a\u4e0d\u65ad\u5730\u901a\u8fc7\u8840\u6db2\u5faa\u73af\u5230\u4e0d\u540c\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u4e2d\u7684\u6ee4\u6ce1\uff0c\u76f4\u5230\u9047\u5230\u7279\u5b9a\u7684\u6297\u539f\u3002\u7f3a\u4e4f\u76ee\u6807\u6297\u539f\u65f6\uff0c\u521d\u59cbB\u7ec6\u80de\u4f1a\u7a7f\u8fc7\u8fd9\u4e00\u533a\u57df\uff0c\u5e76\u91cd\u65b0\u8fdb\u5165\u8840\u6db2\u5faa\u73af\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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FDCs\u662f\u4e00\u79cd\u7279\u6b8a\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\uff0c\u4ec5\u5728\u6dcb\u5df4\u6ee4\u6ce1\u4e2d\u88ab\u53d1\u73b0\u3002\u5b83\u4eec\u4e0d\u8868\u8fbe\u2161\u7c7b\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\u5206\u5b50\uff0c\u800c\u662f\u5c06\u6297\u539f\u6297\u4f53\u590d\u5408\u7269\u4fdd\u7559\u5728\u5176\u8868\u9762\uff0c\u9644\u7740\u5728Fc\u53d7\u4f53\u6216\u8865\u4f53\u53d7\u4f53\u4e0a\u3002\u8fd9\u4e9b\u7ec6\u80de\u5177\u6709\u5728\u6dcb\u5df4\u6ee4\u6ce1\u5185\u5f62\u6210\u7684\u7f51\u7edc\u72b6\u957f\u7a81\u8d77\uff0c\u4e0e\u5176\u4ed6\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u76f8\u4f3c\uff0c\u4f46\u5b83\u4eec\u53ef\u80fd\u4e0e\u9aa8\u9ad3\u4e2d\u8868\u8fbeMHC II\u7c7b\u5206\u5b50\u7684DC\u7684\u6765\u6e90\u4e0d\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u822c\u6765\u8bf4\uff0c\u5355\u7eaf\u7684\u6297\u539f\u4e0d\u80fd\u6fc0\u6d3b\u521d\u59cbB\u7ec6\u80de\u3002\u9700\u8981\u7b2c\u4e8c\u4e2a\u8f85\u52a9\u4fe1\u53f7\u6765\u5b9e\u73b0B\u7ec6\u80de\u7684\u5b8c\u5168\u6fc0\u6d3b(\u7b2c16\u7ae0<\/span>)\u3002\u5728\u6297\u539f\u662f\u86cb\u767d\u8d28\u7684\u60c5\u51b5\u4e0b\uff0c\u7b2c\u4e8c\u4e2a\u4fe1\u53f7\u7531\u5df2\u6fc0\u6d3b\u7684T\u7ec6\u80de\u63d0\u4f9b\uff0c\u8be5T\u7ec6\u80de\u5e26\u6709\u6297\u539f\u53d7\u4f53(TCR)\uff0c\u53ef\u8bc6\u522b\u76f8\u90bbAPC\u663e\u793a\u7684\u80bd-MHC II\u590d\u5408\u7269\u3002\u53ea\u6709\u901a\u8fc7\u8fd9\u79cd\u5f62\u5f0f\u7684B\u7ec6\u80de-T\u7ec6\u80de\u76f8\u4e92\u534f\u4f5c\u624d\u80fd\u542f\u52a8\u514d\u75ab\u53cd\u5e94\u7684\u6297\u539f\u88ab\u79f0\u4e3a\u80f8\u817a\u4f9d\u8d56\u6027\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u679cB\u7ec6\u80de\u9047\u5230\u5b83\u7684\u76ee\u7684\u6297\u539f\uff0cBCR\u4e0e\u6297\u539f\u7ed3\u5408\u5c31\u4f1a\u89e6\u53d1BCR\u6297\u539f\u590d\u5408\u4f53\u5185\u5316\u8fdb\u5165B\u7ec6\u80de\u3002\u7136\u540e\u6297\u539f\u88ab\u964d\u89e3\uff0c\u6297\u539f\u662f\u86cb\u767d\u8d28\u65f6\uff0c\u5b83\u88ab\u52a0\u5de5\u6210\u80bd-MHC II\u7c7b\u590d\u5408\u7269\uff0c\u968f\u540e\u5448\u9012\u5728\u7ec6\u80de\u8868\u9762(\u7b2c10\u7ae0<\/span>)\u3002\u56e0\u6b64\uff0cB\u7ec6\u80de\u53ef\u4ee5\u5411T\u7ec6\u80de\u5448\u9012\u6297\u539f\uff0cT\u7ec6\u80de\u5219\u5e2e\u52a9\u90bb\u8fd1\u7684B\u7ec6\u80de\u8fdb\u884c\u6fc0\u6d3b\u4f5c\u4e3a\u56de\u62a5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u53d1\u4e2d\u5fc3\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u548c\u7c7b\u522b\u8f6c\u6362<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6297\u539f\u523a\u6fc0\u548cT\u7ec6\u80de\u7684\u5e2e\u52a9\u4e0b\uff0c\u6fc0\u6d3b\u7684B\u7ec6\u80de\u5927\u7ea6\u4ee5\u6bcf6\u5c0f\u65f6\u5206\u88c2\u4e00\u6b21\u5f62\u6210\u751f\u53d1\u4e2d\u5fc3\uff0c\u6dcb\u5df4\u7ed3\u5185\u662f\u7531FDCs\u7ec4\u6210\u7684\u6d45\u67d3\u533a\u57df(\u89c1Fig13.3A\u548cB<\/span>)\u3002\u5728\u6b64\u671f\u95f4\uff0c\u514d\u75ab\u7403\u86cb\u767d\u57fa\u56e0\u53d1\u751f\u9ad8\u9891\u7387\u7684\u70b9\u7a81\u53d8\u800c\u6ca1\u6709\u88ab\u7ea0\u6b63\u3002\u8fd9\u4e00\u72ec\u7279\u7684\u8fc7\u7a0b\u88ab\u79f0\u4e3a\u4f53\u7ec6\u80de\u7a81\u53d8\uff0c\u5728\u4efb\u4f55\u5176\u4ed6\u7c7b\u578b\u7684\u7ec6\u80de\u4e2d\u90fd\u4e0d\u5141\u8bb8\u8fd9\u79cd\u60c5\u51b5\u7684\u53d1\u751f\u3002\u4f53\u7ec6\u80de\u7a81\u53d8\u901a\u5e38\u5305\u62ec\u96c6\u4e2d\u5728\u91cd\u6392\u53ef\u53d8\u533a\u7684\u5916\u663e\u5b50\u53ca\u5176\u5468\u56f4\u7684\u5355\u6838\u82f7\u9178\u66ff\u6362\u3002\u91cd\u94fe\u53ef\u53d8\u533a\u5916\u663e\u5b50\u548c\u8f7b\u94fe\u53ef\u53d8\u533a\u5916\u663e\u5b50\u90fd\u53ef\u80fd\u662f\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u9776\u70b9\u3002\u5f15\u5165\u7684\u7a81\u53d8\u53ef\u80fd\u4f1a\u5f71\u54cdBCR\u4e0e\u6297\u539f\u7684\u7ed3\u5408\u60c5\u51b5\u3002\u90a3\u4e9bBCR\u4e0e\u6297\u539f\u9ad8\u4eb2\u548c\u529b\u7684B\u7ec6\u80de(Fig14.4<\/span>)\u4eceFDCs\u548c\u751f\u53d1\u4e2d\u5fc3T\u7ec6\u80de\u83b7\u5f97\u5b58\u6d3b\u4fe1\u53f7(\u9633\u6027\u9009\u62e9)\uff0c\u800c\u90a3\u4e9b\u4e0d\u80fd\u7ed3\u5408\u6297\u539f\u7684B\u7ec6\u80de\u5f88\u5feb\u51cb\u4ea1\u3002\u4e00\u65e6\u611f\u67d3\u5f97\u5230\u63a7\u5236\uff0c\u6297\u539f\u6c34\u5e73\u5f00\u59cb\u4e0b\u964d\u3002\u9633\u6027\u9009\u62e9\u7684B\u7ec6\u80de\u53ef\u80fd\u4f1a\u7ecf\u5386\u989d\u5916\u7684\u51e0\u8f6e\u589e\u6b96\u3001\u4f53\u7ec6\u80de\u7a81\u53d8\u548c\u6297\u539f\u9009\u62e9\u3002\u5176\u7ed3\u679c\u662f\u4ea7\u751f\u9ad8\u4eb2\u548c\u529b\u6297\u4f53\u7684B\u7ec6\u80de\u5b58\u6d3b\u3002\u7531\u6b64\u5f62\u6210\u7684\u4eb2\u548c\u529b\u6210\u719f\u662f\u6297\u4f53\u8d28\u91cf\u968f\u65f6\u95f4\u63d0\u9ad8\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u4f8b\u5982\uff0cFig2.1<\/span>\u663e\u793a\u4e86\u63a5\u79cd\u75ab\u82d7\u540e\u6297\u4f53\u6c34\u5e73\u662f\u5982\u4f55\u63d0\u9ad8\u7684\u3002\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u662f\u56e0\u4e3a\u66f4\u591a\u7684B\u7ec6\u80de\u4ea7\u751f\u6297\u4f53\uff0c\u4f46\u4e5f\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u56e0\u4e3a\u6297\u4f53\u4ea7\u751f\u7684\u4eb2\u548c\u529b\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u800c\u589e\u52a0\u3002\u514d\u75ab\u7403\u86cb\u767d\u7684\u6570\u91cf\u548c\u6297\u4f53\u7ed3\u5408\u7684\u8d28\u91cf(\u4eb2\u548c\u529b)\u90fd\u4f1a\u5f71\u54cd\u6297\u4f53\u6c34\u5e73\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 14.4 <\/span>\u53d1\u80b2B\u7ec6\u80de\u53ef\u80fd\u6709\u51e0\u79cd\u4e0d\u540c\u7684\u547d\u8fd0<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u53d1\u4e2d\u5fc3\u53d1\u751f\u7684\u7b2c\u4e8c\u4e2a\u91cd\u8981\u53d1\u80b2\u8fc7\u7a0b\u662fIg\u7684\u7c7b\u522b\u8f6c\u6362\u3002\u5728\u6210\u719f\u8fc7\u7a0b\u4e2d\uff0cB\u7ec6\u80de\u8868\u8fbeIgM\u548cIgD\uff0c\u4f46\u53ea\u5206\u6cccIgM\u3002\u8bb8\u591a\u60c5\u51b5\u4e0b\u4ea7\u751f\u5176\u4ed6\u7c7b\u522b\u7684\u6297\u4f53\u662f\u5f88\u91cd\u8981\u7684\u3002\u4f8b\u5982\uff0cIgA\u5728\u5e94\u5bf9\u7c98\u819c\u611f\u67d3\u65f6\u662f\u6709\u5e2e\u52a9\u7684\u3002\u800c\u8fd9\u9700\u8981T\u7ec6\u80de\u4e3aIg\u7c7b\u522b\u8f6c\u6362\u63d0\u4f9b\u7279\u5b9a\u7c7b\u578b\u7684\u5e2e\u52a9(\u7b2c6\u7ae0<\/span>\u548c\u7b2c16\u7ae0)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u6210\u719f\u8fc7\u7a0b\u7684\u4efb\u4f55\u9636\u6bb5B\u7ec6\u80de\u90fd\u53ef\u80fd\u79bb\u5f00\u751f\u53d1\u4e2d\u5fc3\uff0c\u6700\u7ec8\u5206\u5316\u4e3a\u6d46\u7ec6\u80de\u6216\u6210\u4e3a\u518d\u5faa\u73af\u7684\u8bb0\u5fc6B\u7ec6\u80de\uff0c\u8fd9\u4e24\u4e2a\u6b65\u9aa4\u90fd\u9700\u8981B\u7ec6\u80de\u7684\u5e2e\u52a9\u3002\u9aa8\u9ad3\u4e2d\u7684\u6d46\u7ec6\u80de\u53ef\u80fd\u4f1a\u5206\u6ccc\u5927\u91cf\u6297\u4f53\u5e76\u4e14\u81f3\u5c11\u6301\u7eed\u6570\u5468\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bb0\u5fc6B\u7ec6\u80de\u4e0d\u5206\u6ccc\u6297\u4f53\uff0c\u4f46\u53ef\u4ee5\u5728\u4e4b\u540e\u9047\u5230\u6297\u539f\u653b\u51fb\u65f6\u8fc5\u901f\u91cd\u65b0\u6fc0\u6d3b\u3002\u518d\u770b\u770bFig<\/span>2.4\uff0c<\/span>\u5728\u7b2c\u4e8c\u6b21\uff0c\u7279\u522b\u662f\u7b2c\u4e09\u6b21\u52a0\u5f3a\u63a5\u79cd\u4e59\u809d\u75ab\u82d7\u540e\uff0c\u6297\u4f53\u6c34\u5e73\u8fc5\u901f\u4e0a\u5347\u3002\u8fd9\u662f\u5178\u578b\u7684\u8bb0\u5fc6B\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u80f8\u817a\u975e\u4f9d\u8d56\u6027\u6297\u539f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u524d\u6240\u8ff0\uff0c\u5bf9\u591a\u80bd\u6297\u539f\u6709\u53cd\u5e94\u7684B\u7ec6\u80de\u9700\u8981\u4e24\u79cd\u4fe1\u53f7\u624d\u80fd\u5b8c\u5168\u6fc0\u6d3b\uff1a\u4e0eBCR\u7684\u7ed3\u5408\u548cT\u7ec6\u80de\u7684\u5e2e\u52a9\u3002\u7136\u800c\uff0c\u6709\u4e9b\u6297\u539f\u80fd\u591f\u5728\u6ca1\u6709T\u7ec6\u80de\u5e2e\u52a9\u7684\u60c5\u51b5\u4e0b\u76f4\u63a5\u6fc0\u6d3bB\u7ec6\u80de\uff0c\u56e0\u6b64\u5b83\u4eec\u88ab\u79f0\u4e3a\u80f8\u817a\u975e\u4f9d\u8d56\u6027(TI)\u6297\u539f\uff0c\u813e\u810f\u4e2d\u6709\u5927\u91cf\u7684TI B\u7ec6\u80de\u3002B\u7ec6\u80de\u76f4\u5230\u513f\u7ae5\u540e\u671f\u624d\u5b8c\u5168\u53d1\u80b2\uff0c\u8fd9\u662f\u513f\u7ae5\u5bb9\u6613\u53cd\u590d\u53d7\u5230\u7ec6\u83cc\u611f\u67d3\u7684\u539f\u56e0\u4e4b\u4e00\u3002TI\u6297\u539f\u5305\u62ec\u91cd\u590d\u805a\u5408\u7269(\u5982\u7ec6\u83cc\u591a\u7cd6)\u548c\u67d0\u4e9b\u7ec6\u83cc\u7ec6\u80de\u58c1\u6210\u5206(\u5982\u8102\u591a\u7cd6)\u3002\u8fd9\u4e9b\u6297\u539f\u90fd\u6709\u591a\u4e2a\u91cd\u590d\u57fa\u5e8f\uff0c\u5e76\u4e0e\u51e0\u4e2aBCR\u7ed3\u5408\uff0c\u8fd9\u6837\u5c31\u514b\u670d\u4e86\u5bf9\u7b2c\u4e8c\u4e2a\u4fe1\u53f7\u7684\u9700\u8981(Fig14.5<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 14.5<\/span> T\u975e\u4f9d\u8d56\u6027(TI)\u6297\u539f\u901a\u8fc7\u7ed3\u5408\u591a\u4e2aB\u7ec6\u80de\u53d7\u4f53(BCR)\u6765\u514b\u670d\u5bf9T\u7ec6\u80de\u5e2e\u52a9\u7684\u9700\u6c42<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TI\u6297\u539f\u901a\u5e38\u662f\u7ec6\u83cc\u8d77\u6e90\u7684\uff0cTI\u53cd\u5e94\u63d0\u4f9b\u4e86\u4e00\u79cd\u5bf9\u7ec6\u83cc\u75c5\u539f\u4f53\u4ea7\u751f\u65e9\u671f\u548c\u7279\u5f02\u6027\u6297\u4f53\u53cd\u5e94\u7684\u65b9\u6cd5\uff0c\u5b83\u80fd\u62b5\u5fa1\u7ec6\u83cc\u75c5\u539f\u4f53\u7684\u4fb5\u88ad\uff0c\u8fd9\u4e9b\u75c5\u539f\u4f53\u53ef\u4ee5\u8fc5\u901f\u7e41\u6b96\uff0c\u5e76\u4f7f\u514d\u75ab\u7cfb\u7edf\u4e0d\u582a\u91cd\u8d1f\u3002\u7136\u800c\uff0c\u7531\u4e8eT\u7ec6\u80de\u901a\u5e38\u4e0d\u88ab\u52a8\u5458\uff0c\u5728TI\u53cd\u5e94\u671f\u95f4\u4ea7\u751f\u7684\u6297\u4f53\u8c31\u7cfb\u662f\u6709\u9650\u7684\uff0c\u56e0\u4e3a\u4e0d\u4f1a\u8bf1\u5bfc\u4fc3\u8fdb\u4eb2\u548c\u529b\u6210\u719f\u7684T\u7ec6\u80de\u4f9d\u8d56\u4e8b\u4ef6\u3001Ig\u7684\u7c7b\u522b\u8f6c\u6362\u548c\u8bb0\u5fc6B\u7ec6\u80de\u7684\u4ea7\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TI B\u7ec6\u80de\u6709\u4e24\u4e2a\u91cd\u8981\u7684\u610f\u4e49\u3002\u9996\u5148\uff0c\u5f00\u53d1\u51fa\u80fd\u591f\u8bf1\u5bfc\u5bf9\u6709\u835a\u819c\u7684\u7ec6\u83cc\u4ea7\u751f\u4fdd\u62a4\u4f5c\u7528\u7684\u75ab\u82d7\uff0c\u5982\u55dc\u8840\u6746\u83cc\u548c\u80ba\u708e\u7403\u83cc(\u80ba\u708e\u94fe\u7403\u83cc)\u3002\u8fd9\u4e9b\u7ec6\u83cc\u4f1a\u5bfc\u81f4\u5927\u91cf\u513f\u7ae5\u6b7b\u4ea1\u3002\u7136\u800c\uff0c\u4ec5\u4ec5\u57fa\u4e8eTI\u6297\u539f\u591a\u7cd6\u7684\u75ab\u82d7\u4e0d\u80fd\u523a\u6fc0T\u7ec6\u80de\u7684\u5e2e\u52a9\uff0c\u56e0\u4e3a\u5b83\u4eec\u4e0d\u5305\u542b\u53ef\u4ee5\u5206\u89e3\u6210\u591a\u80bd\u7684\u86cb\u767d\u8d28\u3002\u56e0\u6b64\u5728\u5f53\u7528\u4f5c\u75ab\u82d7\u65f6\uff0c\u591a\u7cd6\u53ea\u80fd\u8bf1\u5bfc\u514d\u75ab\u8bb0\u5fc6\u529b\u5dee\u7684\u4f4e\u4eb2\u548c\u529bIgM\u6297\u4f53\u3002\u86cb\u767d\u8d28\u7ed3\u5408\u591a\u7cd6\u75ab\u82d7\u5df2\u7ecf\u6210\u529f\u5730\u514b\u670d\u4e86\u8fd9\u4e2a\u95ee\u9898(\u7b2c16\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u63a5\u53d7\u8fc7\u813e\u5207\u9664\u672f\u7684\u4eba\u53d7\u4fb5\u88ad\u6027\u611f\u67d3\u7684\u98ce\u9669\u5f88\u9ad8\u3002\u6b63\u5982\u7b2c13\u7ae0<\/span>\u6240\u63cf\u8ff0\u7684\uff0c\u90e8\u5206\u539f\u56e0\u662f\u8fd9\u4e9b\u60a3\u8005\u5931\u53bb\u4e86\u5927\u91cf\u80fd\u591f\u8fc7\u6ee4\u8840\u6db2\u7684\u813e\u810f\u5de8\u566c\u7ec6\u80de\u3002\u611f\u67d3\u98ce\u9669\u9ad8\u7684\u7b2c\u4e8c\u4e2a\u539f\u56e0\u662fTI B\u7ec6\u80de\u7684\u4e27\u5931\uff0c\u800c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u7ec8\u751f\u4f7f\u7528\u6297\u751f\u7d20\u548c\u7ed3\u5408\u591a\u7cd6\u75ab\u82d7\u6765\u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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B1 \u7ec6\u80de\u4e0e\u5929\u7136\u6297\u4f53<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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B1\u7ec6\u80de\u7531\u672a\u6210\u719f\u7684B\u7ec6\u80de\u524d\u4f53\u7ec6\u80de\u53d1\u80b2\u800c\u6765\uff0c\u4f46\u5b83\u4eec\u5728\u51e0\u4e2a\u91cd\u8981\u65b9\u9762\u4e0e\u4f20\u7edf\u7684B\u7ec6\u80de\u4e0d\u540c\u3002\u9996\u5148\uff0cB1 \u7ec6\u80de\u4f4d\u4e8e\u4e0d\u5bfb\u5e38\u7684\u90e8\u4f4d\uff0c\u5982\u8179\u819c\uff0c\u800c\u4e0d\u662f\u4f20\u7edf\u7684\u6dcb\u5df4\u5668\u5b98\u3002\u7b2c\u4e8c\uff0cB1 \u7ec6\u80de\u8868\u8fbe\u4e0d\u540c\u7684\u7ec6\u80de\u8868\u9762\u6807\u5fd7\u3002\u4f8b\u5982\uff0c\u8bb8\u591a(\u4f46\u4e0d\u662f\u5168\u90e8)B1\u7ec6\u80de\u8868\u8fbeCD5\u7684\u8868\u9762\u6807\u8bb0\uff0c\u8fd9\u5728\u4f20\u7edf\u7684B\u7ec6\u80de\u4e0a\u662f\u4e0d\u5b58\u5728\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u4ece\u9aa8\u9ad3\u524d\u4f53\u7ec6\u80de\u4e0d\u65ad\u66f4\u65b0\u7684\u4f20\u7edfB\u7ec6\u80de\u4e0d\u540c\uff0c\u6210\u4eba\u7684B1\u7ec6\u80de\u901a\u8fc7\u5916\u5468\u7ec4\u7ec7\u4e2d\u8868\u9762\u643a\u5e26IgM(SIgM+)\u7684\u7ec6\u80de\u7684\u6301\u7eed\u5206\u88c2\u6765\u8fdb\u884c\u8865\u5145\uff0c\u4ece\u800c\u786e\u4fdd\u5728\u5176\u4ea7\u751f\u505c\u6b62\u540e\u7684\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4B1\u7fa4\u4f53\u6570\u91cf\u4fdd\u6301\u4e0d\u53d8\u3002\u8fd9\u4e00\u7279\u6027\u53ef\u80fd\u4f1a\u4fc3\u4f7fB1\u7ec6\u80de\uff08\u7279\u522b\u662fCD5+<\/sup>\u7ec6\u80de\uff09\u6210\u4e3a\u4e00\u79cd\u76f8\u5bf9\u5e38\u89c1\u7684B\u7ec6\u80de\u80bf\u7624\u7684\u5e38\u89c1\u6765\u6e90\uff0c\u79f0\u4e3a\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(\u7b2c35\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u7531\u4e8e\u5c11\u6570VH\u57fa\u56e0\u7684\u4f18\u5148\u4f7f\u7528\uff0cB1\u7ec6\u80de\u53d7\u4f53\u8c31\u7cfb\u53d7\u5230\u5f88\u5927\u9650\u5236\uff0c\u5e76\u4e14\u7531\u4e8e\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u7f3a\u4e4fTDT\u7684\u8868\u8fbe\uff0c\u63d2\u5165\u591a\u6837\u6027\u4e5f\u662f\u6709\u9650\u7684\u3002B1\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684BCR\u901a\u5e38\u5bf9\u7ec6\u83cc\u6297\u539f(\u5982\u591a\u7cd6)\u5177\u6709\u53cd\u5e94\u6027\uff0c\u5e76\u4e14\u5b83\u4eec\u7ecf\u5e38\u8868\u73b0\u51fa\u591a\u91cd\u7279\u5f02\u6027\uff0c\u5373\u4e0e\u591a\u79cd\u6297\u539f\u53d1\u751f\u4ea4\u53c9\u53cd\u5e94\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0cB1\u7ec6\u80de\u5728\u751f\u547d\u65e9\u671f\u5bf9\u6297\u75c5\u539f\u4f53\u529f\u80fd\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u652f\u6301\uff0c\u76f4\u5230\u6210\u5e74\u7ec6\u80de\u53d1\u80b2\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0cB1\u7ec6\u80de\u7c7b\u4f3c\u4e8eTI B\u7ec6\u80de(Table14.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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Table 14.2<\/span> B\u7ec6\u80de\u7684\u5206\u7c7b<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7136\u800c\uff0cB1\u7ec6\u80de\u5728\u4e0d\u53d7\u6297\u539f\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\u4ea7\u751f\u6297\u4f53\u65f6\uff0c\u6297\u4f53\u7ecf\u5e38\u4e0e\u81ea\u8eab\u6297\u539f\u53d1\u751f\u4ea4\u53c9\u53cd\u5e94\u3002\u81ea\u53d1\u4ea7\u751f\u7684\u81ea\u8eab\u53cd\u5e94\u6027\u6297\u4f53\u88ab\u79f0\u4e3a\u5929\u7136\u6297\u4f53\uff0c\u6709\u65f6\u53ef\u80fd\u4f1a\u5f15\u8d77\u81ea\u8eab\u514d\u75ab\uff0c\u5982\u7b2c28\u7ae0<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6700\u540e\uff0c\u7531\u4e8eB1 \u7ec6\u80de\u53ea\u4f7f\u7528\u6709\u9650\u7684\u57fa\u56e0\u8fdb\u884c\u91cd\u6392\uff0c\u4e0d\u4f1a\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb(\u901a\u8fc7\u4eb2\u548c\u529b\u6210\u719f\u6216\u7c7b\u522b\u8f6c\u6362)\u6765\u5b8c\u5584\u5b83\u4eec\u7684\u53cd\u5e94\uff0c\u4e5f\u4e0d\u4f1a\u5f62\u6210\u514d\u75ab\u8bb0\u5fc6\uff0c\u6240\u4ee5\u5b83\u4eec\u53ef\u80fd\u4e0e\u5148\u5929\u6027\u514d\u75ab\u7cfb\u7edf\u6709\u66f4\u591a\u7684\u5171\u540c\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 14.1<\/span>\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u6027\u767d\u8840\u75c5<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u4e00\u540d7\u5c81\u7684\u5973\u5b69\uff0c\u80fd\u91cf\u6444\u5165\u4e0d\u8db3\u548c\u4f53\u91cd\u51cf\u8f7b3\u5468\u3002\u8138\u8272\u82cd\u767d\uff0c\u6dcb\u5df4\u7ed3\u80bf\u5927\uff0c\u817f\u90e8\u6709\u7600\u70b9\u3002\u8840\u5e38\u89c4\u7ed3\u679c\u793a\u8840\u7ea2\u86cb\u767d\u548c\u8840\u5c0f\u677f\u8ba1\u6570\u8f83\u4f4e(TABLE14.3)\u3002\u767d\u7ec6\u80de\u6570\u589e\u591a\uff0c\u4f46\u51e0\u4e4e\u6240\u6709\u7684\u767d\u7ec6\u80de\u90fd\u662f\u6bcd\u7ec6\u80de\uff08\u975e\u5e38\u4e0d\u6210\u719f\u7684\u767d\u7ec6\u80de\uff09\u3002\u8840\u6db2\u5b66\u4e13\u5bb6\u89c2\u5bdf\u8fd9\u4e9b\u7ec6\u80de\u540e\u8ba4\u4e3a\u5b83\u4eec\u53ef\u80fd\u662f\u672a\u6210\u719f\u7684\u6dcb\u5df4\u7ec6\u80de\uff0c\u5e76\u91c7\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u6765\u786e\u5b9a(Table14.4<\/span>)\u3002\u7531\u4e8eCD19\u5448\u9633\u6027\uff0c\u6d41\u5f0f\u7ec6\u80de\u672f\u663e\u793a\u5f02\u5e38\u7ec6\u80de\u662fB\u7ec6\u80de\uff0c\u5e76\u4e14\u8fd9\u4e9bB\u7ec6\u80de\u8868\u8fbeTDT\uff0c\u8868\u660e\u5b83\u4eec\u975e\u5e38\u4e0d\u6210\u719f\u3002\u8fd9\u5bf9\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(ALL)\u7684\u8bca\u65ad\u975e\u5e38\u6709\u610f\u4e49\u3002\u8fd9\u4e00\u8bca\u65ad\u662f\u901a\u8fc7\u5bf9\u9aa8\u9ad3\u6837\u672c\u7684\u68c0\u67e5\u6765\u786e\u8ba4\u7684\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 14.3 <\/span>\u5168\u8840\u7ec6\u80de\u8ba1\u6570<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 14.4 <\/span>\u6d41\u5f0f\u7ec6\u80de\u672f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

ALL\u662f\u5927\u591a\u6570\u53d1\u8fbe\u56fd\u5bb6\u6700\u5e38\u89c1\u7684\u513f\u7ae5\u764c\u75c7\uff0c80%\u60a3\u6709ALL\u7684\u513f\u7ae5\u53ef\u4ee5\u6cbb\u6108\u3002\u6076\u6027\u7ec6\u80de\u8d77\u6e90\u4e8e\u539f\u59cbB\u7ec6\u80de(\u89c1Fig14.1<\/span>)\u3002\u867d\u7136\u66b4\u9732\u4e8e\u8f90\u5c04\u662fALL\u53d1\u75c5\u7684\u5df2\u77e5\u5371\u9669\u56e0\u7d20\u4e4b\u4e00\uff0c\u4f46\u5927\u591a\u6570ALL\u513f\u7ae5\u4f3c\u4e4e\u5e76\u4e0d\u662f\u56e0\u66b4\u9732\u4e8e\u8f90\u5c04\u4e0b\u60a3\u75c5\u7684\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/p>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u848b\u4fca\u535a \u7f57\u4f73\u4f73<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u9648\u6653\u610f<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u5b8b\u4e50<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/span><\/span><\/span><\/strong>
<\/span><\/span><\/section>\n
<\/span>
<\/section>\n

<\/strong><\/strong><\/p>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span>
<\/strong><\/strong><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\n

<\/p>\n

\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n

<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u6b63\u5982\u7b2c6\u7ae0\u548c\u7b2c11\u7ae0\u6240\u8ba8\u8bba\u7684\u90a3\u6837\uff0cB\u7ec6\u80de\u8868\u9762\u7684\u819c\u7ed3\u5408\u6297\u4f53\u5206\u5b50\u6784\u6210\u8d1f\u8d23\u8bc6\u522b\u6297\u539f\u7684B\u7ec6\u80de\u53d7\u4f53(BCR)\u7684\u5173…<\/p>\n","protected":false},"author":1,"featured_media":1877,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[64],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1878"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=1878"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1878\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/1877"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=1878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=1878"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=1878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}