{"id":1888,"date":"2021-08-05T11:23:20","date_gmt":"2021-08-05T03:23:20","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2021\/08\/05\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac19%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%94%9f%e7%90%86%e5%8a%9f%e8%83%bd%e7%ae%80%e8%bf%b0\/"},"modified":"2021-08-05T11:23:20","modified_gmt":"2021-08-05T03:23:20","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac19%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%94%9f%e7%90%86%e5%8a%9f%e8%83%bd%e7%ae%80%e8%bf%b0","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2021\/08\/05\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac19%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%94%9f%e7%90%86%e5%8a%9f%e8%83%bd%e7%ae%80%e8%bf%b0\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c19\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u751f\u7406\u529f\u80fd\u7b80\u8ff0"},"content":{"rendered":"
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\u5bfc \u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7b2c\u4e8c\u8282\uff08\u7b2c3-9\u7ae0\uff09\u8ba8\u8bba\u4e86\u4e0e\u6297\u539f\u8bc6\u522b\u6709\u5173\u7684\u57fa\u56e0\u548c\u5206\u5b50\u4e4b\u540e\uff0c\u7b2c\u4e09\u8282\uff08\u7b2c10-18\u7ae0\uff09\u8fdb\u5165\u5230\u5bf9\u7ec6\u80de\u3001\u7ec4\u7ec7\u548c\u5668\u5b98\u7684\u8ba8\u8bba\uff0c\u4ee5\u53ca\u5bf9\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u4f5c\u4e3a\u4e00\u79cd\u751f\u7406\u7cfb\u7edf\u8fdb\u884c\u4e86\u4e00\u4e2a\u66f4\u5b8f\u89c2\u7684\u6982\u89c8\u3002<\/p>\n

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\u00b7<\/strong><\/span> <\/span>\u6297\u539f\u53d7\u4f53\u8c31\u7cfb\u5982\u4f55\u5229\u7528\u57fa\u56e0\u91cd\u6392\u53d1\u5c55\u8d77\u6765<\/span><\/p>\n

\u00b7 <\/strong><\/span>\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u5982\u4f55\u5904\u7406\u548c\u5448\u9012\u80fd\u88abT\u7ec6\u80de\u8bc6\u522b\u7684\u6297\u539f<\/span><\/p>\n

\u00b7<\/strong> <\/span>\u5e7c\u7a1aB\u3001T\u6dcb\u5df4\u7ec6\u80de\u5982\u4f55\u8bc6\u522b\u6297\u539f\uff0c\u7136\u540e\u88ab\u6fc0\u6d3b\u5e76\u5206\u5316\u4e3a\u6548\u5e94\u7ec6\u80de<\/span><\/p>\n

\u00b7<\/span><\/strong> <\/span>APC\u4e0eB\u3001T\u6dcb\u5df4\u7ec6\u80de\u5982\u4f55\u5728\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u4e2d\u76f8\u4e92\u4f5c\u7528<\/span><\/p>\n

\u00b7<\/span><\/strong>\u6dcb\u5df4\u7ec6\u80de\u5982\u4f55\u518d\u5faa\u73af\u5230\u6dcb\u5df4\u7ec4\u7ec7\u548c\u5916\u5468\u7ec4\u7ec7<\/span><\/p>\n

\u00b7<\/strong><\/span>\u5982\u4f55\u53d1\u751f\u7279\u5b9a\u7684\u53cd\u5e94\uff0c\u4f8b\u5982\uff1a\u514d\u75ab\u7403\u86cb\u767d(Igs)IgG\u3001IgA\u3001IgE\u6216TH1\u3001TH2\u3001TH17\u7b49\u6548\u5e94<\/span><\/p>\n

\u00b7 <\/strong><\/span>\u5982\u4f55\u4fdd\u6301\u5bf9\u5148\u524d\u53cd\u5e94\u7684\u8bb0\u5fc6\uff0c\u4ee5\u4fbf\u5728\u518d\u6b21\u9047\u5230\u76f8\u540c\u75c5\u539f\u4f53\u65f6\u505a\u51fa\u66f4\u5feb\u901f\u3001\u66f4\u6709\u6548\u7684\u53cd\u5e94<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6211\u4eec\u5728\u7b2c10\u7ae0<\/span><\/a>\u4e2d\u8bc1\u5b9e\uff0c\u6297\u539f\u7ecf\u8fc7APCs\u5904\u7406\u540e\u624d\u80fd\u4e0e\u03b1\u03b2T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7ed3\u5408\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u6297\u539f\u5904\u7406\u7684\u9014\u5f84(\u80de\u8d28\u9014\u5f84\u6216\u56ca\u6ce1\u9014\u5f84)\u51b3\u5b9a\u4e86\u6297\u539f\u662f\u7531\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC II)\u7c7b\u5206\u5b50\u63d0\u5448\u7ed9CD4+T\u8f85\u52a9\u7ec6\u80de\u4e0a\u7684TCR\uff0c\u8fd8\u662f\u7531MHC I\u7c7b\u5206\u5b50\u63d0\u5448\u7ed9CD8+\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u4e0a\u7684TCR\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7b2c11\u7ae0<\/span><\/a>\u548c\u7b2c16\u7ae0<\/span><\/a>\u4ecb\u7ecd\u4e86\u4ee5\u4e0b\u5185\u5bb9\uff1a<\/p>\n

\u00b7 <\/span><\/strong>B\u7ec6\u80de\u53d7\u4f53(BCR)\u548cTCR\u7684\u7ed3\u6784\u548c\u529f\u80fd<\/p>\n

\u00b7 <\/span><\/strong>\u5171\u53d7\u4f53\u548c\u5171\u523a\u6fc0\u5206\u5b50\u5728\u4f18\u5316\u6297\u539f\u53d7\u4f53\u529f\u80fd\u4e2d\u7684\u4f5c\u7528<\/p>\n

\u00b7<\/span><\/strong> <\/span>B\u3001T\u6dcb\u5df4\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u4e0e\u4fe1\u53f7\u8f6c\u5bfc\u673a\u5236\u7684\u5173\u7cfb<\/p>\n

\u8fd9\u4e9b\u5185\u5bb9\u4f1a\u8ba9\u4f60\u4e86\u89e3\u6dcb\u5df4\u7ec6\u80de\u662f\u5982\u4f55\u6210\u4e3a\u6548\u5e94\u7ec6\u80de\uff0c\u4ee5\u53ca\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316\u7684\u8fc7\u7a0b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7b2c14\u7ae0<\/span><\/a>\u548c\u7b2c15\u7ae0<\/span><\/a>\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86B\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u7279\u5f02\u6027\u662f\u5982\u4f55\u5f62\u6210\u7684\u3002\u6211\u4eec\u4e86\u89e3\u5230\uff0c\u5728\u9aa8\u9ad3\u548c\u80f8\u817a\u4e2d\u7684B\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u53d1\u80b2\u8fc7\u7a0b\u4e2d\uff0c\u4f1a\u53d1\u751f\u6709\u5e8f\u7684\u57fa\u56e0\u91cd\u6392\u8fc7\u7a0b\uff0c\u8fd8\u63cf\u8ff0\u4e86\u80f8\u817a\u7ec6\u80de\u548cB\u7ec6\u80de\u524d\u4f53\u5982\u4f55\u5728\u6297\u539f\u523a\u6fc0\u4e0b\u53d1\u80b2\u6210\u719f\u4e3aT\u3001B\u6548\u5e94\u7ec6\u80de\u3002B\u3001T\u6dcb\u5df4\u7ec6\u80de\u53ca\u5176\u5404\u81ea\u7684\u6297\u539f\u7279\u5f02\u6027\u53d7\u4f53\u7684\u53d1\u80b2\u6709\u8bb8\u591a\u76f8\u4f3c\u4e4b\u5904\uff0c\u4ed6\u4eec\u4e4b\u95f4\u6700\u5927\u7684\u533a\u522b\u662f\uff0cBCR\u5728\u66b4\u9732\u4e8e\u6297\u539f\u540e\u4f1a\u7ee7\u7eed\u6539\u53d8<\/span>\uff0c\u4eb2\u548c\u529b\u6210\u719f<\/span><\/span>\u548c\u7c7b\u522b\u8f6c\u6362\u8fc7\u7a0b\u53ef\u4ee5\u4f7f\u6548\u5e94B\u7ec6\u80de\u5728\u514d\u75ab\u5e94\u7b54\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u66f4\u9ad8\u4eb2\u548c\u529b\u3001\u66f4\u6709\u6548\u7684\u6297\u4f53\u5206\u5b50\u3002\u867d\u7136TCR\u5728\u514d\u75ab\u5e94\u7b54\u8fc7\u7a0b\u4e2d\u4e0d\u4f1a\u6539\u53d8\u7ed3\u6784\uff0c\u4f46\u514b\u9686\u6269\u589e\u7684\u8bb0\u5fc6T\u7ec6\u80de\u5728\u9047\u5230\u6297\u539f\u65f6\u80fd\u591f\u901a\u8fc7\u8868\u89c2\u9057\u4f20\u4fee\u9970\u66f4\u5feb\u3001\u66f4\u6709\u6548\u5730\u505a\u51fa\u53cd\u5e94(\u7b2c17\u7ae0<\/span><\/a>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u00b7<\/span><\/strong> <\/span>\u6dcb\u5df4\u5668\u5b98\u7684\u7ec6\u80de\u7ec4\u7ec7\u548c\u4e3b\u8981\u529f\u80fd<\/p>\n

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(1)B\u7ec6\u80de\u548cT\u7ec6\u80de\u7fa4\u4f53\u4e2d\u8bf1\u5bfc\u8010\u53d7\u7684\u673a\u5236\uff1b  <\/p>\n

(2)\u79ef\u6781\u6216\u6d88\u6781\u7684\u9009\u62e9\u673a\u5236\uff1b<\/p>\n

(3)\u4e2d\u67a2\u548c\u5916\u5468\u8010\u53d7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7ae0\u5145\u5f53\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u548c\u5148\u5929\u514d\u75ab\u53cd\u5e94\u4e4b\u95f4\u7684\u6865\u6881\uff0c\u5b83\u4ecb\u4e8e\u672c\u4e66\u4e3b\u8981\u6d89\u53ca\u5206\u5b50\u7684\u4e00\u8282\u548c\u4ecb\u7ecd\u514d\u75ab\u5b66\u66f4\u5168\u9762\u7cfb\u7edf\u6cbb\u7597\u7684\u4e00\u8282\u4e4b\u95f4\u3002\u672c\u7ae0\u7684\u5176\u4f59\u90e8\u5206\u65e8\u5728\u5e2e\u52a9\u8bfb\u8005\u66f4\u597d\u8854\u63a5\u8fd9\u4e24\u4e2a\u90e8\u5206\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7cfb\u7edf\u4e0d\u540c\u65b9\u9762\u4e4b\u95f4\u7684\u8054\u7cfb\u8fd9\u4e00\u4e3b\u9898\u4e5f\u662f\u672c\u4e66\u4e0b\u4e00\u8282\u7684\u6838\u5fc3\uff0c\u8fd9\u4e00\u8282\u4e3b\u8981\u63cf\u8ff0\u4e86\u5148\u5929\u514d\u75ab\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b63\u5982\u5728\u4e0b\u4e00\u8282\u4e2d\u5c06\u66f4\u5168\u9762\u5730\u9610\u8ff0\u7684\u90a3\u6837\uff0c\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53(PRR)\u6240\u8d77\u7684\u4f5c\u7528\u662f\u5148\u5929\u7cfb\u7edf\u548c\u9002\u5e94\u6027\u7cfb\u7edf\u4e4b\u95f4\u8054\u7cfb\u7684\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\uff0c\u4f8b\u5982Toll\u6837\u53d7\u4f53(TLRs\uff1b\u89c1BOX 19.1<\/span>)\u3002\u7b2c2\u7ae0<\/span><\/a>\u4ecb\u7ecd\u4e86\u4e0e\u7518\u9732\u805a\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20(MBL)\u548c\u8865\u4f53\u6fc0\u6d3b\u7684\u51dd\u96c6\u7d20\u9014\u5f84\u76f8\u5173\u7684PRRs\u7684\u6982\u5ff5\u3002PRRs\u53ef\u4ee5\u4e0e\u611f\u67d3\u5fae\u751f\u7269\u5171\u6709\u4f46\u5728\u810a\u690e\u52a8\u7269\u4e2d\u627e\u4e0d\u5230\u7684\u5206\u5b50\u7ed3\u5408\uff0c\u4f8b\u5982\uff0c\u9175\u6bcd\u7ec6\u80de\u58c1\u4e2d\u53d1\u73b0\u7684\u540d\u4e3a\u7518\u9732\u805a\u7cd6\u7684\u590d\u6742\u78b3\u6c34\u5316\u5408\u7269\uff0c\u4ee5\u53ca\u9769\u5170\u6c0f\u9634\u6027\u7ec6\u83cc\u7684\u8102\u591a\u7cd6(LPS)\u7ec6\u80de\u58c1\u6210\u5206\u3002\u8102\u591a\u7cd6\u662f\u4e00\u79cd\u53ef\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u5148\u5929\u514d\u75ab\u53cd\u5e94\u7684\u6fc0\u6d3b\u5242(\u89c1BOX 19.1)<\/span>\u3002\u50cfLPS\u548c\u7518\u9732\u805a\u7cd6\u8fd9\u6837\u7684\u9776\u6807\u901a\u5e38\u80fd\u5728\u51e0\u4e2a\u4e0d\u540c\u7684\u7269\u79cd\u4e0a\u53d1\u73b0\uff0c\u751a\u81f3\u5728\u51e0\u4e2a\u4e0d\u76f8\u5173\u7684\u751f\u7269\u4f53\u4e0a\u4e5f\u80fd\u627e\u5230\uff0c\u5b83\u4eec\u88ab\u79f0\u4e3a\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f(PAMPs)\u3002\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u8fd8\u53ef\u4ee5\u8bc6\u522b\u5176\u4ed6\u4e0d\u662f\u7531\u611f\u67d3\u5f15\u8d77\u7684\u6709\u5bb3\u8fc7\u7a0b\uff0c\u5982\u70e7\u4f24\u6216\u5176\u4ed6\u4f24\u5bb3\u3002\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0c\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u8bc6\u522b\u4e0e\u635f\u4f24\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f(DAMPs).\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u54fa\u4e73\u52a8\u7269\u4f7f\u7528\u51e0\u79cd\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u8fdb\u884c\u5148\u5929\u5bbf\u4e3b\u9632\u5fa1\u53cd\u5e94(Fig 19.1<\/span>)\u3002\u5b83\u4eec\u53ef\u4ee5\u4f4d\u4e8e\u7ec6\u80de\u819c\u6216\u7ec6\u80de\u8d28\u4e2d\uff0c\u4e5f\u53ef\u4ee5\u5728\u8840\u6d46\u4e2d\u3002\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u523a\u6fc0\u7ec6\u80de\u8fdb\u884c\u541e\u566c(\u7b2c21\u7ae0<\/span>)\u6216\u5206\u6ccc\u6297\u83cc\u80bd\u3002\u5f53\u8865\u4f53\u88ab\u6fc0\u6d3b\u65f6\uff0c\u5b83\u53ef\u4ee5\u76f4\u63a5\u653b\u51fb\u5fae\u751f\u7269\uff0c\u800c\u5e76\u4e0d\u603b\u662f\u9700\u8981\u5176\u4ed6\u7ec6\u80de\u7684\u5e2e\u52a9(\u7b2c20\u7ae0<\/span>)\u3002\u4e00\u4e9b\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u7684\u591a\u6001\u6027\u53ef\u80fd\u4f1a\u5bfc\u81f4\u75be\u75c5(\u89c1BOX 19.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 19.1<\/span>\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u89e6\u53d1\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u6d3b\u52a8\uff0c\u4e5f\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u8fd9\u4e9b\u5305\u62ec\u8840\u6d46\u4e2d\u7684Toll\u6837\u53d7\u4f53(TLRs)(A)\u3001NOD2(B)\u548c\u8865\u4f53(C)\u3002IL\uff0c\u767d\u7ec6\u80de\u4ecb\u7d20\uff1bLPS\uff0c\u8102\u591a\u7cd6\uff1bTH1\uff0cT\u8f85\u52a9\u7ec6\u80de1<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u7ec6\u80de\u5728\u5165\u4fb5\u540e\u5f88\u5feb\u5c31\u4f1a\u4f7f\u7528PRPs\u6765\u68c0\u6d4b\u75c5\u539f\u4f53\u7684\u5b58\u5728\u3002\u968f\u540e\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u5bf9\u5165\u4fb5\u7684\u75c5\u539f\u4f53\u91c7\u53d6\u884c\u52a8\uff0c\u4f8b\u5982\u541e\u566c\u5b83\u4eec\u6216\u5206\u6ccc\u6297\u83cc\u80bd\u3002\u6b64\u5916\uff0c\u5f53\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u8bc6\u522b\u611f\u67d3\u65f6\uff0c\u5b83\u4eec\u8fd8\u4f1a\u901a\u8fc7\u53d1\u9001\u5371\u9669\u4fe1\u53f7\u6765\u63d0\u9192\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u5371\u9669\u4fe1\u53f7\u53ef\u80fd\u662f\u7ec6\u80de\u56e0\u5b50–\u4f8b\u5982\u767d\u7ec6\u80de\u4ecb\u7d20(IL)12\u621617–\u6216\u8005\u662f\u5171\u523a\u6fc0\u5206\u5b50\u6216\u7ec6\u80de\u7c98\u9644\u5206\u5b50\u8868\u8fbe\u589e\u52a0\u3002\u8fd9\u4e9b\u4fe1\u53f7\u5bf9\u4e8e\u542f\u52a8\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4e0d\u4f1a\u5728\u6ca1\u6709\u5371\u9669\u4fe1\u53f7\u7684\u60c5\u51b5\u4e0b\u5bf9\u611f\u67d3\u505a\u51fa\u53cd\u5e94\u3002\u8fd9\u662f\u5916\u5468\u8010\u53d7\u7684\u4e00\u79cd\u5f62\u5f0f\uff0c\u5b83\u662f\u5148\u5929\u548c\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u7684\u534f\u8c03\u884c\u52a8\uff0c\u4ece\u800c\u6709\u6548\u5730\u5bf9\u6297\u75c5\u539f\u4f53\u7684\u653b\u51fb\u3002\u8fd9\u672c\u4e66\u7684\u4e0b\u4e00\u8282\u5c06\u66f4\u8be6\u7ec6\u5730\u4ecb\u7ecd\u5148\u5929\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 19.1<\/span> Toll\u6837\u53d7\u4f53\u4f5c\u4e3a\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u548c\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u7ebd\u5e26\u7684\u4f5c\u7528<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\u5728\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u4e0a\u53d1\u73b0\u7684\u67d0\u4e9b\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53(PRR)\u53ef\u4ee5\u4f5c\u4e3a\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f(PAMPs)\u7684\u53d7\u4f53\uff0c\u5982\u8102\u591a\u7cd6(LPS)\uff0c\u5e76\u5728\u4e0e\u8fd9\u4e9b\u5206\u5b50\u7ed3\u5408\u65f6\u4f20\u9012\u6fc0\u6d3b\u4fe1\u53f7(\u89c1Fig 19.2<\/span>)\u3002\u8102\u591a\u7cd6\u662f\u8bb8\u591a\u7ec6\u83cc\u7ec6\u80de\u58c1\u7684\u7ec4\u6210\u90e8\u5206\u3002\u7136\u540e\uff0c\u6fc0\u6d3b\u7684APC\u53d1\u51fa\u5371\u9669\u4fe1\u53f7\uff0c\u4f8b\u5982\u901a\u8fc7\u7ec6\u80de\u56e0\u5b50\uff0c\u63d0\u9192\u548c\u6fc0\u6d3b\u6dcb\u5df4\u7ec6\u80de\u3002\u5728\u5bfb\u627e\u5230\u54fa\u4e73\u52a8\u7269\u4e2d\u88ab\u79f0\u4e3a Toll \u53d7\u4f53\u7684\u7b49\u6548\u5206\u5b50\u540e\uff0c\u6267\u884c\u6b64\u64cd\u4f5c\u7684 PRR \u88ab\u786e\u5b9a\u4e3a\u7ec6\u80de\u8868\u9762\u53d7\u4f53\uff0c\u8fd9\u4e9b\u5206\u5b50\u5728\u6606\u866b\u7684\u514d\u75ab\u7cfb\u7edf\u4e2d\u5177\u6709\u5173\u952e\u4f5c\u7528(\u7b2c21\u7ae0<\/span>)\u3002\u679c\u8747\u3001\u9ed1\u8179\u679c\u8747\u548c\u5176\u4ed6\u6606\u866b\u5177\u6709\u826f\u597d\u7684\u5148\u5929\u514d\u75ab\u7cfb\u7edf\uff0c\u80fd\u591f\u62b5\u6297\u5fae\u751f\u7269\u611f\u67d3\u3002\u679c\u8747\u5bbf\u4e3b\u9632\u5fa1\u7684\u4e00\u4e2a\u4e3b\u8981\u65b9\u9762\u662f\u6297\u83cc\u80bd\u7684\u91ca\u653e\u3002\u4eba\u7c7b\u62e5\u6709\u4e0eToll\u540c\u6e90\u7684\u5206\u5b50\uff1a\u88ab\u79f0\u4e3aToll\u6837\u53d7\u4f53(TLRs)\u5206\u5b50\u5bb6\u65cf\u3002\u6709\u51e0\u79cd\u4e0d\u540c\u7684TLR\uff0c\u6bcf\u4e2aTLR\u8bc6\u522b\u4e0d\u540c\u7684\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\u3002\u8bb8\u591a\u7c7b\u578b\u7684\u4eba\u7c7b\u7ec6\u80de\u80fd\u591f\u8868\u8fbeTLR\u5bb6\u65cf\u7684\u6210\u5458\uff0c\u5b83\u4eec\u4f5c\u4e3a\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\u53d1\u6325\u4f5c\u7528\uff0c\u5e76\u4e0eLPS\u7b49\u5206\u5b50\u7ed3\u5408\u3002\u8fd9\u79cdLPS\u7ed3\u5408\u89e6\u53d1\u4e86TLR\uff0cTLR\u7684\u80de\u8d28\u7ed3\u6784\u57df\u53ef\u542f\u52a8\u4e00\u4e2a\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\uff0c\u53ef\u5f15\u8d77\u541e\u566c\u7b49\u53cd\u5e94(\u7b2c21\u7ae0<\/span>)\u3002\u8be5\u4fe1\u53f7\u8fd8\u6fc0\u6d3b\u4e86\u8f6c\u5f55\u56e0\u5b50\u6838\u56e0\u5b50\u03baB(NF-\u03baB)\uff0c\u4ece\u800c\u589e\u52a0\u4e86\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u5982\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1(TNF-\u03b1)\u3001\u767d\u7ec6\u80de\u4ecb\u7d20(IL)1\u30016\u548c12\uff1b\u8d8b\u5316\u56e0\u5b50\u5982IL-8\uff1b\u4ee5\u53ca\u5171\u523a\u6fc0\u5206\u5b50(\u89c1Fig 19.1<\/span>)\u3002\u7ec6\u80de\u56e0\u5b50\u53ef\u5438\u5f15\u6297\u539f\u7279\u5f02\u6027\u6dcb\u5df4\u7ec6\u80de\uff0c\u4ece\u800c\u4ea7\u751f\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 19.2 <\/span>Toll\u6837\u53d7\u4f53(TLRs)\u5728\u5fae\u751f\u7269\u6fc0\u6d3b\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u4e2d\u7684\u4f5c\u7528\u3002LPS, \u8102\u591a\u7cd6\uff1bNF-\u03baB, \u6838\u56e0\u5b50\u03baB\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 19.2 <\/span>\u514b\u7f57\u6069\u75c5\u4e0eNOD2\u57fa\u56e0\u591a\u6001\u6027<\/span><\/p>\n<\/section>\n<\/section>\n

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27\u5c81\u5973\u6027\uff0c\u8179\u6cfb1\u5e74\uff0c\u5177\u6709\u8179\u75db\u548c\u4f53\u91cd\u51cf\u8f7b\u7684\u75c5\u53f2\u3002\u7caa\u4fbf\u4e2d\u6709\u8840\u6db2\u548c\u7c98\u6db2\u3002\u54e5\u54e5\u4e24\u5e74\u524d\u88ab\u8bca\u65ad\u51fa\u60a3\u6709\u514b\u7f57\u6069\u75c5(CD)\u3002\u5979\u8fdb\u884c\u4e86\u7ed3\u80a0\u955c\u68c0\u67e5\uff0c\u68c0\u67e5\u7ed3\u679c\u663e\u793a\u5979\u7684\u7ed3\u80a0\u6709\u7247\u72b6\u6e83\u75a1\uff0c\u56de\u80a0\u672b\u7aef\u6709\u66f4\u5e7f\u6cdb\u7684\u6e83\u75a1\u3002\u6d3b\u68c0\u663e\u793a\u708e\u75c7\u5f71\u54cd\u5230\u4e86\u6574\u4e2a\u80a0\u58c1\u539a\u5ea6,\u75c7\u72b6\u8868\u73b0\u4e3aCD,CD\u662f\u4e00\u79cd\u708e\u75c7\u6027\u80a0\u9053\u75be\u75c5\uff0c\u80a0\u9053\u6162\u6027\u708e\u75c7\u5bfc\u81f4\u6e83\u75a1\u3002\u6709\u8bc1\u636e\u8868\u660e\uff0cT\u8f85\u52a9\u7ec6\u80de1(TH1)\u548cTH17\u7ec6\u80de\u90fd\u4fc3\u8fdb\u4e86\u708e\u75c7\u53d1\u751f\u3002<\/span><\/p>\n

\u5144\u5f1f\u59d0\u59b9\u5982\u679c\u60a3\u6709CD\uff0c\u90a3\u4e48\u81ea\u5df1\u60a3CD\u7684\u53ef\u80fd\u6027\u662f\u6b63\u5e38\u4eba\u768430\u500d\u3002\u9057\u4f20\u57fa\u7840\u53ef\u80fd\u662f\u7531\u4e8eNOD2\u57fa\u56e0\u7684\u591a\u6001\u6027\u9057\u4f20\u6240\u81f4\u3002\u591a\u6001\u6027\u662f\u4e00\u79cd\u53ef\u4ee5\u5728\u5065\u5eb7\u4eba\u4e2d\u53d1\u73b0\u7684\u9057\u4f20\u53d8\u5f02\uff0c\u5728CD\u60a3\u8005\u4e2d\u53d1\u73b0\u7684\u591a\u6001\u6027\u5728\u5065\u5eb7\u4eba\u4e2d\u4e5f\u6709\u53d1\u73b0\uff0c\u4f46\u5728CD\u60a3\u8005\u4e2d\u66f4\u4e3a\u5e38\u89c1\u3002\u6b64\u5916\uff0c\u5e76\u4e0d\u662f\u6bcf\u4e2aCD\u60a3\u8005\u90fd\u9057\u4f20\u4e86\u8fd9\u79cd\u591a\u6001\u6027\uff0c\u56e0\u6b64\u5b83\u4eec\u53ea\u662fCD\u53d1\u5c55\u7684\u51e0\u4e2a\u8d21\u732e\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n

NOD2\u662f\u4e00\u79cd\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53(PRR)\uff0c\u5b58\u5728\u4e8e\u5305\u62ec\u80a0\u4e0a\u76ae\u7ec6\u80de\u5728\u5185\u7684\u591a\u79cd\u7ec6\u80de\u7684\u80de\u6d46\u4e2d\u3002NOD2\u7684\u914d\u4f53\u662f\u80bd\u805a\u7cd6\uff0c\u5b83\u5b58\u5728\u4e8e\u8bb8\u591a\u4e0d\u540c\u7684\u7ec6\u83cc\u7ec6\u80de\u58c1\u4e2d\u3002\u5f53NOD2\u8bc6\u522b\u80bd\u805a\u7cd6\u65f6\uff0c\u7ec6\u80de\u88ab\u523a\u6fc0\u5206\u6ccc\u6297\u83cc\u80bd\u548c\u7ec6\u80de\u56e0\u5b50\uff0c\u5305\u62ec\u767d\u7ec6\u80de\u4ecb\u7d20(IL)23\u548c12\u3002<\/span><\/p>\n

\u90a3\u4e9b\u9057\u4f20\u4e86CD\u4e2d\u51fa\u73b0\u7684NOD2\u591a\u6001\u6027\u7684\u4eba\u4ea7\u751f\u4e86\u4e00\u79cdNOD2\u5206\u5b50\uff0c\u8fd9\u79cd\u5206\u5b50\u5728\u7ed3\u5408\u80bd\u805a\u7cd6\u65b9\u9762\u6548\u7387\u8f83\u4f4e\u3002\u7531\u6b64\u53d1\u5c55\u51fa\u4e86\u4e00\u79cd\u7406\u8bba\uff0c\u5373\u9057\u4f20\u8fd9\u4e9bNOD2\u57fa\u56e0\u591a\u6001\u6027\u7684\u4eba\u5bb9\u6613\u53d7\u5230\u80a0\u9053\u7ec6\u83cc\u611f\u67d3\uff0c\u4ece\u800c\u5f15\u53d1CD\u3002\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd8\u6ca1\u6709\u627e\u5230\u652f\u6301\u8fd9\u4e00\u7406\u8bba\u7684\u8bc1\u636e\u3002\u5f02\u5e38\u7684NOD2\u5206\u5b50\u4ecd\u7136\u6709\u53ef\u80fd\u662f\u901a\u8fc7\u5176\u4ed6\u65b9\u5f0f\u89e6\u53d1\u4e86\u6162\u6027\u708e\u75c7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u848b\u4fca\u535a  \u9648\u8389\u8679<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u7f57\u6e05\u7075<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u9648\u79cb\u8c37 \u5b8b\u4e50<\/span><\/section>\n
\u7ec8\u5ba1 | \u738b\u5764<\/span> \u8096\u5efa\u52c7<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

<\/section>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5373\u5c06\u5f00\u59cb\uff0c\u656c\u8bf7\u671f\u5f85\uff01<\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/span><\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
<\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/span><\/a>
<\/p>\n

\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
<\/p>\n

\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
<\/p>\n

HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
<\/p>\n

PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
<\/p>\n

Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
<\/p>\n

\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
<\/p>\n

PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\n

<\/p>\n

\u957f\u6309\u4e0a\u65b9\u4e8c\u7ef4\u7801\u5373\u53ef\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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