{"id":1890,"date":"2021-08-19T14:52:25","date_gmt":"2021-08-19T06:52:25","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2021\/08\/19\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac20%e7%ab%a0%ef%bc%9a%e5%9b%ba%e6%9c%89%e5%85%8d%e7%96%ab%e7%9a%84%e9%98%b2%e5%be%a1%e4%bd%9c%e7%94%a8\/"},"modified":"2021-08-19T14:52:25","modified_gmt":"2021-08-19T06:52:25","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac20%e7%ab%a0%ef%bc%9a%e5%9b%ba%e6%9c%89%e5%85%8d%e7%96%ab%e7%9a%84%e9%98%b2%e5%be%a1%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2021\/08\/19\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac20%e7%ab%a0%ef%bc%9a%e5%9b%ba%e6%9c%89%e5%85%8d%e7%96%ab%e7%9a%84%e9%98%b2%e5%be%a1%e4%bd%9c%e7%94%a8\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c20\u7ae0\uff1a\u56fa\u6709\u514d\u75ab\u7684\u9632\u5fa1\u4f5c\u7528"},"content":{"rendered":"
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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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\u5bfc \u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u80fd\u591f\u7a81\u7834\u4eba\u4f53\u7269\u7406\u5c4f\u969c\u7684\u611f\u67d3\u4f1a\u6fc0\u6d3b\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u5206\u5b50\u5c4f\u969c\uff0c\u5176\u4e2d\u5305\u62ec\u5e72\u6270\u7d20\u7cfb\u7edf\u548c\u8865\u4f53\u7cfb\u7edf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7531\u4e00\u7cfb\u5217\u975e\u7279\u5f02\u6027\u9632\u5fa1\u7ec4\u6210\uff0c\u53ef\u4ee5\u968f\u65f6\u62b5\u6297\u611f\u67d3\u3002\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u5728\u8bb8\u591a\u65b9\u9762\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u6709\u6240\u4e0d\u540c\uff08Table 20.1\uff09\u3002<\/span>\u63a5\u4e0b\u6765\u7684\u56db\u7ae0\u5c06\u8ba8\u8bba\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u8fd0\u4f5c\u65b9\u5f0f\u4ee5\u53ca\u4e0e\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u76f8\u4e92\u4f5c\u7528\u7684\u65b9\u5f0f\u3002\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u5177\u6709\u4e24\u4e2a\u5173\u952e\u4f5c\u7528\uff1a\uff081\uff09\u5b83\u4f7f\u7528\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRRs\uff09\u8bc6\u522b\u4e0e\u75c5\u539f\u4f53\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f\uff08PAMP\uff09\uff0c\u5e76\u5bf9\u5165\u4fb5\u7684\u75c5\u539f\u4f53\u505a\u51fa\u5feb\u901f\u53cd\u5e94\uff1b\uff082\uff09\u5b83\u8fd8\u53ef\u6fc0\u6d3b\u6574\u4e2a\u8eab\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u7684\u5176\u4ed6\u90e8\u5206\u548c\u7ec4\u7ec7\u3002\u4e3a\u6b64\uff0c\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u4f1a\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u548c\u5176\u4ed6\u51e0\u79cd\u708e\u75c7\u4ecb\u8d28\uff0c\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u548c\u708e\u75c7\u4ecb\u8d28\u88ab\u79f0\u4e3a\u5371\u9669\u4fe1\u53f7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 20.1 \u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4e0e\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u5dee\u5f02 <\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u611f\u67d3\u969c\u788d<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ae\u80a4\u3001\u547c\u5438\u9053\u548c\u80c3\u80a0\u9053\u5df2\u8fdb\u5316\u4e3a\u7279\u6b8a\u7684\u53ef\u62b5\u6297\u611f\u67d3\u7684\u5c4f\u969c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ae\u80a4<\/span><\/strong><\/p>\n<\/section>\n

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\u5c3d\u7ba1\u8bb8\u591a\u751f\u7269\u90fd\u751f\u6d3b\u5728\u76ae\u80a4\u8868\u9762\uff0c\u4f46\u662f\u89d2\u8d28\u7ec6\u80de<\/span>\u7684\u81f4\u5bc6\u5916\u5c42\u963b\u6b62\u4e86\u8fd9\u4e9b\u751f\u7269\u6e17\u900f\u5230\u66f4\u6df1\u5c42\u7684\u7ec4\u7ec7\u4e2d\u3002\u8f83\u6df1\u5c42\u7684\u6d3b\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u662f\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u6d3b\u6027\u6210\u5206\u3002\u5982\u679c\u8fd9\u4e9b\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u88ab\u7834\u574f\uff0c\u5b83\u4eec\u4f1a\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\uff0c\u4f8b\u5982\u767d\u4ecb\u7d208\uff08IL-8\uff09\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\uff0c\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u4e5f\u662f\u7d2b\u5916\u7ebf\u7167\u5c04\u540e\u53d1\u751f\u708e\u75c7\u53cd\u5e94\u7684\u539f\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ae\u80a4\u8fd8\u5305\u542b\u6717\u683c\u6c49\u65af\u7ec6\u80de\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u8c31\u7cfb\u7684\u524d\u54e8\u7ec6\u80de\u3002\u66b4\u9732\u4e8e\u5fae\u751f\u7269\u540e\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5c06\u8fc1\u79fb\u81f3\u5c40\u90e8\u6dcb\u5df4\u7ed3\uff0c\u5e76\u5411T\u7ec6\u80de\u5448\u9012\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ae\u80a4\u662f\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7ec4\u6210\u4e2d\u7684\u5178\u578b\u4ee3\u8868\uff0c\u5b83\u5177\u6709\u5bf9\u523a\u6fc0\u5feb\u901f\u53cd\u5e94\uff0c\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u547c\u5438\u9053\u53ef\u5206\u4e3a\u4e0a\u6bb5\u548c\u4e0b\u6bb5\u3002\u4e0a\u547c\u5438\u9053\u59cb\u4e8e\u9f3b\u5b50\uff0c\u6b62\u4e8e\u7ec6\u652f\u6c14\u7ba1\uff0c\u5e76\u53d7\u5230\u7c98\u819c\u7ea4\u6bdb\u7684\u4fdd\u62a4\u3002\u676f\u72b6\u7ec6\u80de\u5206\u6ccc\u7684\u7c98\u6db2\u53ef\u5f62\u6210\u4e00\u5c42\u8986\u76d6\u547c\u5438\u9053\u5e76\u6355\u83b7\u5fae\u751f\u7269\u7684\u4fdd\u62a4\u5c42\u3002\u7ea4\u6bdb\u5c06\u7c98\u6db2\u5411\u53e3\u8154\u548c\u9f3b\u5b50\u63a8\u52a8\uff0c\u901a\u8fc7\u6253\u55b7\u568f\u6216\u54b3\u55fd\u5c06\u5176\u6e05\u9664\u3002\u60a3\u6709\u4e00\u4e9b\u4e9b\u75be\u75c5\u7684\u60a3\u8005\uff0c\u5982\u56ca\u6027\u7ea4\u7ef4\u5316\u4e2d\u7c98\u6db2\u5206\u6ccc\u5f02\u5e38\uff0c\u7ea4\u6bdb\u5728\u539f\u53d1\u6027\u7ea4\u6bdb\u8fd0\u52a8\u4e0d\u826f\u75c7\u4e2d\u7684\u8fd0\u52a8\u7f3a\u9677\uff0c\u4f1a\u5bfc\u81f4\u547c\u5438\u9053\u611f\u67d3\u7684\u53cd\u590d\u51fa\u73b0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e0b\u547c\u5438\u9053\uff0c\u672b\u7aef\u7ec6\u652f\u6c14\u7ba1\u548c\u80ba\u6ce1\u4e2d\uff0c\u7ea4\u6bdb\u548c\u7c98\u6db2\u5c42\u4f1a\u963b\u788d\u6c27\u6c14\u7684\u6269\u6563\u3002\u8fd9\u91cc\u7684\u4e3b\u8981\u9632\u5fa1\u624b\u6bb5\u662f\u7531\u6392\u5217\u5728\u80ba\u6ce1\uff08II\u578b\u80ba\u6ce1\u7ec6\u80de\uff09\u4e2d\u4e13\u95e8\u7684\u7ec6\u80de\u5206\u6ccc\u7684\u8868\u9762\u6d3b\u6027\u5242\u3002\u8868\u9762\u6d3b\u6027\u5242\u662f\u86cb\u767d\u8d28\u548c\u78f7\u8102\u7684\u6df7\u5408\u7269\uff0c\u53ef\u9632\u6b62\u80ba\u6ce1\u5728\u547c\u6c14\u65f6\u584c\u9677\u3002\u8868\u9762\u6d3b\u6027\u5242\u542b\u6709\u75c5\u539f\u4f53\u7ed3\u5408\u86cb\u767d\uff0c\u662f\u80f6\u539f\u51dd\u96c6\u7d20\u5bb6\u65cf\u7684\u6210\u5458\uff08Fig 20.1<\/span>\uff09\u3002\u8fd9\u4e9b\u5206\u5b50\u5177\u6709\u6a21\u5f0f\u8bc6\u522b\u4f5c\u7528\uff0c\u5177\u6709\u53ef\u4e0e\u5fae\u751f\u7269\u7cd6\u7ed3\u5408\u7684\u7403\u5f62\u51dd\u96c6\u7d20\u6837\u5934\u90e8\uff0c\u4ee5\u53ca\u4e0e\u541e\u566c\u7ec6\u80de\u6216\u8865\u4f53\u7ed3\u5408\u7684\u957f\u80f6\u539f\u6837\u5c3e\u5df4\u3002\u6b64\u5916\uff0c\u547c\u5438\u9053\u7684\u4e24\u4e2a\u90e8\u5206\u4e5f\u90fd\u4f9d\u8d56\u514d\u75ab\u7403\u86cb\u767d\uff0c\u5982\u6297\u4f53\u7f3a\u4e4f\u75c7\u60a3\u8005\u7684\u547c\u5438\u9053\u611f\u67d3\u9891\u7387\u660e\u663e\u4e0a\u5347\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u547c\u5438\u9053\u9ecf\u819c\u4e5f\u4f1a\u5bf9\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u4fe1\u53f7\u4f5c\u51fa\u53cd\u5e94\u3002\u6b63\u5982\u7b2c16\u7ae0<\/span><\/a>\u6240\u8bb2\uff0cT\u8f85\u52a9\u7ec6\u80de17\uff08TH17\uff09\u5728\u54cd\u5e94\u7ec6\u80de\u5916\u75c5\u539f\u4f53\u523a\u6fc0\u65f6\u4f1a\u5206\u6cccIL-17\uff0cIL-17\u53ef\u523a\u6fc0\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u53d1\u751f\u53cd\u5e94\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5728TH2\u53cd\u5e94\u671f\u95f4\uff0cIL-4\u8fd8\u4f1a\u523a\u6fc0\u676f\u72b6\u7ec6\u80de\u7684\u589e\u751f\u548c\u7c98\u6db2\u5206\u6ccc\u589e\u52a0\u4ee5\u53ca\u6c14\u9053\u5468\u56f4\u5e73\u6ed1\u808c\u7684\u80a5\u5927\u3002IL-4\u7684\u8fd9\u4e9b\u4f5c\u7528\u662f\u4e3a\u4e86\u5bf9\u4ed8\u8815\u866b\u7b49\u5927\u578b\u75c5\u539f\u4f53\u8fdb\u5316\u800c\u6765\u7684\uff0c\u4f46\u5728\u4e00\u4e9b\u56fd\u5bb6\uff0c\u5b83\u4eec\u66f4\u5e38\u89c1\u4e8e\u8fc7\u654f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 20.1<\/span>  \u80f6\u539f\u51dd\u96c6\u7d20\u5bb6\u65cf\u5305\u62ec\u8868\u9762\u6d3b\u6027\u86cb\u767d\u548c\u7518\u9732\u805a\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20\uff0c\u4e24\u8005\u90fd\u662f\u91cd\u8981\u7684\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6d88\u5316\u9053<\/strong><\/span><\/p>\n<\/section>\n

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\u80c3\u7684\u4f4epH\u503c\u662f\u62b5\u5fa1\u80a0\u9053\u611f\u67d3\u7684\u4e3b\u8981\u9632\u5fa1\u624b\u6bb5\u4e4b\u4e00\u3002\u4f8b\u5982\uff0c\u65e0\u6cd5\u5206\u6ccc\u80c3\u9178\u7684\u60a3\u8005\u611f\u67d3\u6c99\u95e8\u6c0f\u83cc\u7684\u98ce\u9669\u660e\u663e\u63d0\u5347\u3002\u80a0\u9053\u88ab\u6570\u4ee5\u4e07\u4ebf\u8ba1\u7684\u7ec6\u83cc\u5b9a\u5c45\uff0c\u8fd9\u4e9b\u7ec6\u83cc\u901a\u5e38\u662f\u65e0\u5bb3\u7684\uff0c\u5e76\u6291\u5236\u75c5\u539f\u83cc\u7684\u751f\u957f\u3002\u80a0\u9053\u4e0a\u76ae\u4f1a\u5206\u6ccc\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\uff0c\u4e0d\u662f\u9632\u5fa1\u75c5\u539f\u7ec6\u83cc\uff0c\u800c\u662f\u901a\u8fc7TGF-\u03b2\u8bf1\u5bfcT\u8c03\u8282\u7ec6\u80de\uff08Tregs\uff09\u7684\u5206\u5316\u548c\u805a\u96c6\uff0c\u8fd9\u6709\u52a9\u4e8e\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u8010\u53d7\u65e0\u5bb3\u5171\u751f\u7ec6\u83cc\u7684\u5b58\u5728\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u80de\u5916\u5206\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u4f9d\u8d56\u4e8e\u53ef\u4ee5\u5bf9\u611f\u67d3\u505a\u51fa\u5feb\u901f\u53cd\u5e94\u7684\u86cb\u767d\u8d28\u5bb6\u65cf\u3002I\u578b\u5e72\u6270\u7d20\uff08IFN\uff09\u5728\u5c40\u90e8\u611f\u67d3\u65f6\u4ea7\u751f\uff0c\u5e76\u53ef\u76f4\u63a5\u6291\u5236\u75c5\u539f\u4f53\u7684\u751f\u957f\u3002\u80f6\u539f\u51dd\u96c6\u7d20\uff0c\u8865\u4f53\u548cC\u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u5176\u5b9e\u662f\u7ec4\u6210\u6027\u4ea7\u751f\u7684\u86cb\u767d\uff0c\u867d\u7136\u5728\u611f\u67d3\u8fc7\u7a0b\u4e2d\u5b83\u4eec\u7684\u542b\u91cf\u8f83\u9ad8\uff0c\u5e76\u4e14\u4f1a\u7ed3\u5408\u5230\u75c5\u539f\u4f53\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5e72\u6270\u7d20<\/span><\/strong><\/p>\n<\/section>\n

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\u5e72\u6270\u7d20\u4e4b\u6240\u4ee5\u88ab\u79f0\u4e3a\u5e72\u6270\u7d20\uff0c\u662f\u56e0\u4e3a\u7528\u5e72\u6270\u7d20\u5904\u7406\u7684\u7ec6\u80de\u5bf9\u75c5\u6bd2\u7684\u611f\u67d3\u5177\u6709\u62b5\u6297\u529b\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u5e72\u6270\u7d20\u4f1a\u5e72\u6270\u75c5\u6bd2\u590d\u5236\u3002I\u578bIFN\uff08IFN-\u03b1\u548cIFN-\u03b2\uff09\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\u6700\u5f3a\uff0c\u800c\u4eba\u7c7b\u552f\u4e00\u7684II\u578b\u5e72\u6270\u7d20IFN-\u03b3\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\u6700\u5f31\u3002\u5e72\u6270\u7d20-\u03b3\u53ef\u7531TH1\u7ec6\u80de\u4ea7\u751f\uff0c\u5728\u6fc0\u6d3b\u83b7\u5f97\u6027\u514d\u75ab\u53cd\u5e94\u65b9\u9762\u6bd4\u5728\u6291\u5236\u75c5\u6bd2\u590d\u5236\u65b9\u9762\u66f4\u6709\u6548(\u7b2c16\u7ae0<\/a>)<\/span>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2022 I <\/strong>\u578b\u5e72\u6270\u7d20\u7531\u591a\u79cd\u7ec6\u80de\u5206\u6ccc\uff0c\u4f8b\u5982\u80a0\u58c1\u4e0a\u76ae\u7ec6\u80de\u3002\u8bb8\u591a\u7ec6\u80de\u4f1a\u54cd\u5e94\u975e\u7279\u5f02\u6027\u635f\u4f24\uff08\u4f8b\u5982\u521b\u4f24\u6216\u653e\u5c04\u635f\u4f24\uff09\u800c\u4ea7\u751fIFN\u3002\u4f46\u662f\uff0cI\u578bIFN\u6700\u6709\u6548\u7684\u751f\u4ea7\u8005\u662f\u4e00\u79cd\u88ab\u79f0\u4e3a\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\u7684APC\uff0c\u5b83\u4f1a\u5728\u611f\u67d3\u540e\u5206\u6cccIFN\u3002\u8fd9\u4e9b\u4e13\u95e8\u7684APC\uff08\u7b2c12\u7ae0<\/span><\/a>\uff09\u4f1a\u54cd\u5e94\u53cc\u94feRNA\u800c\u5206\u6cccI\u578bIFN\uff0c\u5e76\u4f7f\u7528\u79f0\u4e3aToll\u6837\u53d7\u4f533\u7684PRR\u5bf9\u5176\u8fdb\u884c\u8bc6\u522b\uff08\u7b2c19\u7ae0<\/span><\/a>\uff09\u3002\u53cc\u94feRNA\u4e0d\u5b58\u5728\u4e8e\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\uff0c\u800c\u662f\u5728\u7ec6\u80de\u7684\u80de\u5185\u611f\u67d3\u8fc7\u7a0b\u4e2d\u7531\u75c5\u6bd2\u4ea7\u751f\u7684\u3002\u53cc\u94feRNA\u662fPAMP\u7684\u4e00\u4e2a\u5f88\u597d\u7684\u4f8b\u5b50\u3002\u5b83\u7684\u5b58\u5728\u8868\u660e\u6b63\u5728\u53d1\u751f\u75c5\u6bd2\u611f\u67d3\uff0c\u4f46\u5e76\u4e0d\u8868\u660e\u75c5\u6bd2\u7684\u786e\u5207\u7c7b\u578b\u3002Fig 20.2<\/span>\u4e2d\u5c55\u793a\u4e86I\u578b\u5e72\u6270\u7d20\u7684\u591a\u79cd\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2022 I <\/strong>\u578b\u5e72\u6270\u7d20\u901a\u8fc7\u6fc0\u6d3b\u4e24\u6761\u7ec6\u80de\u5185\u9176\u9014\u5f84\u6765\u6291\u5236\u75c5\u6bd2\u590d\u5236\uff0c\u8fd9\u4e24\u6761\u9176\u9014\u5f84\u53ef\u964d\u89e3\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5e76\u6291\u5236\u75c5\u6bd2\u4fe1\u4f7fRNA(mRNA)\u7684\u8f6c\u5f55\u3002I <\/strong>\u578bIFN\u4ec5\u4f5c\u7528\u4e8e\u90bb\u8fd1\u7ec6\u80de\uff0c\u4f46\u662f\u53ef\u4ee5\u6709\u6548\u6291\u5236\u75c5\u6bd2\u590d\u5236\u3002\u8fd9\u79cd\u77ed\u7a0b\u6548\u5e94\u88ab\u63cf\u8ff0\u4e3a\u65c1\u5206\u6ccc\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u2022 I <\/strong>\u578b\u5e72\u6270\u7d20\u53ef\u6fc0\u6d3b\u6297\u539f\u63d0\u5448\u76f8\u5173\u8f6c\u8fd0\u4f53\uff08TAP\uff09\uff0c\u80bd\u8f6c\u8fd0\u86cb\u767d\u548c\u86cb\u767d\u9176\u4f53\u76f8\u5173\u7684\u8f6c\u8fd0\u86cb\u767d\u7684\u6d3b\u6027\uff08\u7b2c10\u7ae0<\/span><\/a>\uff09\uff0c\u8fd8\u53ef\u589e\u52a0MHC I\u7684\u8868\u8fbe\uff08\u7b2c8\u7ae0<\/span><\/a>\uff09\uff0c\u4ece\u800c\u589e\u52a0\u4e86\u591a\u80bd\u4e0eMHC I \u7684\u7ed3\u5408\uff0c\u589e\u5f3aCD8+<\/sup>T\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c I<\/strong> \u578b\u5e72\u6270\u7d20\u8fd8\u53ef\u4fc3\u8fdbTH1\u7ec6\u80de\u7684\u53d1\u80b2\uff08\u7b2c15\u7ae0<\/span><\/a>\uff09\u4ee5\u53ca\u6fc0\u6d3b\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\uff08\u7b2c21\u7ae0<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u75c5\u6bd2\u611f\u67d3\u7684\u6570\u5c0f\u65f6\u5185\uff0cI<\/strong> \u578b\u5e72\u6270\u7d20\u4f1a\u88ab\u8bf1\u5bfc\u5206\u6ccc\u5e76\u6291\u5236\u75c5\u6bd2\u590d\u5236\uff0c\u4fc3\u4f7fNK\u7ec6\u80de\u7834\u574f\u88ab\u611f\u67d3\u7684\u7ec6\u80de\u3002\u5c3d\u7ba1IFN\u6539\u5584\u4e86MHC I\u4e0a\u7684\u6297\u539f\u5448\u9012\uff0c\u4f46\u521d\u59cbT\u7ec6\u80de\u548c\u6297\u4f53\u53cd\u5e94\u53ef\u80fd\u9700\u8981\u957f\u8fbe\u4e00\u5468\u7684\u65f6\u95f4\u624d\u80fd\u53d1\u5c55\u8d77\u6765\u3002\u56e0\u6b64\uff0c\u5e72\u6270\u7d20\u7684\u5feb\u901f\u53cd\u5e94\uff0c\u53ef\u5728\u542f\u52a8\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u524d\u53d1\u6325\u6297\u611f\u67d3\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u91cd\u7ec4IFN-\u03b1\u5df2\u7ecf\u4f5c\u4e3a\u4e00\u79cd\u751f\u7269\u5236\u836f\u4e0e\u66f4\u5e38\u89c4\u7684\u6297\u75c5\u6bd2\u836f\u7269\u4e00\u8d77\u7528\u4f5c\u6cbb\u7597\u75c5\u6bd2\u6027\u809d\u708e\u3002IFN-\u03b1\u7684\u7597\u6548\u4e3b\u8981\u662f\u7531\u5176\u6297\u75c5\u6bd2\u4f5c\u7528\u4ecb\u5bfc\uff0c\u90e8\u5206\u662f\u901a\u8fc7\u523a\u6fc0\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002\u91cd\u7ec4IFN\u53ef\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u5927\u91cf\u5408\u6210\u3002\u4e0e\u4f20\u7edf\u7684\u6297\u75c5\u6bd2\u836f\u7269\u4e0d\u540c\uff0cIFN-\u03b1\u5fc5\u987b\u901a\u8fc7\u6ce8\u5c04\u7ed9\u836f\uff0c\u4f1a\u4ea7\u751f\u4e00\u4e9b\u526f\u4f5c\u7528\u3002\u7531\u4e8e\u5b83\u662f\u4e00\u79cd\u86cb\u767d\u8d28\u5206\u5b50\uff0c\u56e0\u6b64\u6700\u7ec8\u53ef\u4ee5\u901a\u8fc7\u4e2d\u548c\u6297\u4f53\u6765\u7ec8\u6b62\u53cd\u5e94\u3002\u7b2c36\u7ae0<\/span>\u8ba8\u8bba\u4e86\u751f\u7269\u836f\u7269\u7684\u4e00\u4e9b\u4e34\u5e8a\u526f\u4f5c\u7528\u548c\u751f\u4ea7\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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IFN-\u03b1\u4e5f\u5df2\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u80bf\u7624\uff0c\u6700\u5e38\u89c1\u7684\u662f\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5\u3002\u5c3d\u7ba1IFN\u4f3c\u4e4e\u53ef\u8bf1\u5bfc\u6076\u6027\u7ec6\u80de\u51cb\u4ea1\u6216\u6210\u719f\uff0c\u4f46\u786e\u5207\u7684\u4f5c\u7528\u65b9\u5f0f\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u611f\u67d3\u8fc7\u7a0b\u4e2d\uff0c\u5de8\u566c\u7ec6\u80de\u548c\u5176\u4ed6\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u4f1a\u5206\u6ccc\u5176\u4ed6\u7ec6\u80de\u56e0\u5b50\uff0c\u4f8b\u5982IL-1\uff0cIL-6\u548cTNF\u3002\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u53ef\u6fc0\u6d3b\u7279\u5f02\u6027\u514d\u75ab\u7cfb\u7edf\u5e76\u5f15\u8d77\u6025\u6027\u671f\u53cd\u5e94\uff08\u89c1Box 20.1<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.2<\/span>  \u5e72\u6270\u7d20\u5305\u62ec\u03b1\u3001\u03b2\u548c\u03b3\u4e09\u79cd\u5f62\u5f0f<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53<\/span><\/strong><\/p>\n<\/section>\n

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\u5c3d\u7ba1\u8865\u4f53\u6210\u5206\u6570\u91cf\u8f83\u591a<\/span>\uff0c\u4f46\u6574\u4e2a\u7cfb\u7edf\u662f\u7b80\u5355\u6613\u61c2\u7684\u3002\u4e5d\u4e2a\u57fa\u672c\u8865\u4f53\u6210\u5206\u7f16\u53f7\u4e3aC1-C9\u3002\u5f53\u5b83\u4eec\u88ab\u6fc0\u6d3b\u65f6\uff0c\u8865\u4f53\u88ab\u5206\u4e3a\u5927\u7247\u6bb5\u548c\u5c0f\u7247\u6bb5\u3002\u8fd9\u4e9b\u5c0f\u7247\u6bb5\u79f0\u4e3aC3a\uff0cC4a\u7b49\u3002\u8865\u4f53\u6839\u636e\u75c5\u539f\u4f53\u79cd\u7c7b\u7684\u4e0d\u540c\u4f1a\u6709\u4e09\u79cd\u6fc0\u6d3b\u9014\u5f84\uff0c\u4e09\u79cd\u9014\u5f84\u90fd\u4f1a\u6fc0\u6d3b\u5173\u952e\u6210\u5206C3\uff0c\u968f\u540e\u901a\u8fc7\u6fc0\u6d3b\u4e09\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u6548\u5e94\u5b50\u5206\u5b50\u53d1\u6325\u4f5c\u7528\uff08Fig 20.3<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u53ef\u4ee5\u901a\u8fc7\u6297\u4f53\u548c\u6297\u539f\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u800c\u88ab\u6fc0\u6d3b\u3002\u8865\u4f53\u4e4b\u6240\u4ee5\u88ab\u547d\u540d\u4e3a\u201c\u8865\u4f53\u201d\uff0c\u662f\u56e0\u4e3a\u5b83\u53ef\u4ee5\u4fc3\u8fdb\u6297\u4f53\u7684\u4f5c\u7528\uff0c\u56e0\u4e3a\u5355\u72ec\u7684\u6297\u4f53\u65e0\u6cd5\u6740\u6b7b\u5927\u591a\u6570\u7ec6\u83cc\uff0c\u9700\u8981\u8fd9\u4e9b\u8865\u4f53\u5206\u5b50\u6765\u4e00\u8d77\u53d1\u6325\u6740\u83cc\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 20.3<\/span> \u8865\u4f53\u7ea7\u8054\u53cd\u5e94\u6982\u8ff0<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6fc0\u6d3b\u8865\u4f53<\/span><\/strong><\/p>\n<\/section>\n

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\u8865\u4f53C3\u53ef\u4ee5\u901a\u8fc7\u4e09\u79cd\u9014\u5f84\u6fc0\u6d3b\uff08Fig 20.4<\/span>\uff09\uff1a(1\uff09\u51dd\u96c6\u7d20\u9014\u5f84\uff1b\uff082\uff09\u7ecf\u5178\u9014\u5f84\uff1b\uff083\uff09\u65c1\u8def\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.4<\/span> C3\u7684\u6fc0\u6d3b\u53ef\u4ee5\u901a\u8fc7\u4e09\u79cd\u9014\u5f84\u4e2d\u7684\u4efb\u4f55\u4e00\u79cd\uff1bMBL\uff0c\u7518\u9732\u805a\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u51dd\u96c6\u7d20\u9014\u5f84<\/p>\n<\/section>\n

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\u7518\u9732\u805a\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20\uff08MBL\uff09\u662f\u4e00\u79cd\u80f6\u539f\u51dd\u96c6\u7d20\uff0c\u80fd\u591f\u901a\u8fc7\u5176\u51dd\u96c6\u7d20\u90e8\u5206\u4e0e\u7ec6\u83cc\u4e0a\u5b58\u5728\u7684\u78b3\u6c34\u5316\u5408\u7269\u7ed3\u5408\u3002\u5c3d\u7ba1MBL\u81ea\u8eab\u6ca1\u6709\u9176\u6d3b\u6027\uff0c\u4f46\u5728\u51dd\u96c6\u7d20\u90e8\u5206\u7ed3\u5408\u7ec6\u83cc\u540e\uff0cMBL\u80f6\u539f\u6837\u7ed3\u6784\u57df\u53ef\u95f4\u63a5\u6fc0\u6d3b\u4e0b\u4e00\u4e2a\u8865\u4f53\u6210\u5206C2\u548cC4\uff0c\u5b83\u4eec\u53ef\u5171\u540c\u6fc0\u6d3b\u6570\u767e\u4e2aC3\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ecf\u5178\u9014\u5f84<\/p>\n<\/section>\n

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\u7ecf\u5178\u9014\u5f84\u662f\u6700\u65e9\u53d1\u73b0\u7684\uff0c\u8be5\u9014\u5f84\u7531\u6297\u4f53\u548c\u6297\u539f\u7684\u514d\u75ab\u590d\u5408\u7269\u89e6\u53d1\u3002C1\u662f\u8d77\u59cb\u86cb\u767d\uff0c\u5f53\u8db3\u591f\u7684Fc\u90e8\u5206\u8db3\u591f\u63a5\u8fd1\u65f6\uff0c\u5b83\u5c31\u80fd\u8bc6\u522b\u514d\u75ab\u7403\u86cb\u767d\uff08Ig\uff09\u5206\u5b50\u7684Fc\u90e8\u5206\u3002\u5f53\u6297\u539f\u7ed3\u5408\u51e0\u4e2aIg\u5206\u5b50\u65f6\uff0c\u6700\u6709\u53ef\u80fd\u53d1\u751f\u8fd9\u79cd\u60c5\u51b5\u3002\u7531\u4e8eIgM\u5177\u6709\u4e94\u4e2aFc\u90e8\u5206\uff0c\u56e0\u6b64\u7279\u522b\u5bb9\u6613\u4e0eC1\u7ed3\u5408\u3002C1\u4e5f\u6ca1\u6709\u9176\u6d3b\u6027\uff0c\u4f46\u662f\u4e0eFc\u7ed3\u5408\u540e\uff0c\u5b83\u80fd\u591f\u6fc0\u6d3bC2\u548cC4\uff0c\u4ece\u800c\u6fc0\u6d3b\u591a\u4e2aC3\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u65c1\u8def\u9014\u5f84<\/p>\n<\/section>\n

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C3\u4e0d\u662f\u7a33\u5b9a\u7684\u5206\u5b50\uff0c\u5e76\u4e14\u4e0d\u65ad\u5730\u8fdb\u884c\u81ea\u53d1\u7684\u4f4e\u6c34\u5e73\u6fc0\u6d3b\uff0c\u8fd9\u4e3b\u8981\u53d1\u751f\u5728\u7ec6\u80de\u8868\u9762\u3002\u6b63\u5e38\u7ec6\u80de\u53ef\u8868\u8fbe\u963b\u6b62C3\u81ea\u53d1\u6d3b\u5316\u7684\u8868\u9762\u8865\u4f53\u6291\u5236\u5242\uff08\u89c1Fig 20.10<\/span>\uff09\u3002\u75c5\u539f\u4f53\u8868\u9762\u7f3a\u4e4f\u8865\u4f53\u6291\u5236\u5242\uff0c\u56e0\u6b64C3\u7684\u81ea\u53d1\u6fc0\u6d3b\u53ef\u4ee5\u6301\u7eed\u8fdb\u884c\u3002\u8865\u4f53\u6291\u5236\u5242\u57fa\u56e0\u53d1\u751f\u7a81\u53d8\u7684\u4eba\u4f1a\u53d1\u5c55\u4e3a\u975e\u5178\u578b\u6eb6\u8840\u5c3f\u6bd2\u75c7\u7efc\u5408\u5f81\u3002\u4ed6\u4eec\u5728\u5185\u76ae\u7ec6\u80de\u548c\u8840\u5c0f\u677f\u8868\u9762\u4e0a\u4e0d\u53d7\u63a7\u5236\u5730\u6fc0\u6d3b\u4e86C3\uff0c\u5bfc\u81f4\u4f53\u5185\u5f62\u6210\u4e86\u5e7f\u6cdb\u7684\u8840\u6813\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u7cfb\u7edf\u7684\u65e9\u671f\u90e8\u5206\u4e5f\u53ef\u68c0\u6d4b\u5230\u7531\u4e8e\u574f\u6b7b\u800c\u6b7b\u4ea1\u7684\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7684\u6b7b\u4ea1\u901a\u5e38\u662f\u7ee7\u53d1\u4e8e\u7269\u7406\u6216\u4ee3\u8c22\u635f\u4f24\u3002\u574f\u6b7b\u5bfc\u81f4\u7684\u7ec6\u80de\u6b7b\u4ea1\u662f\u4e00\u4e2a\u4e0d\u53d7\u63a7\u5236\u7684\u8fc7\u7a0b\uff0c\u6b7b\u4ea1\u7684\u7ec6\u80de\u4f3c\u4e4e\u4f1a\u91ca\u653e\u51e0\u79cd\u80fd\u591f\u6fc0\u6d3b\u8865\u4f53\u7ea7\u8054\u7684\u5206\u5b50\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u4efb\u4f55\u7c7b\u578b\u7684\u7ec4\u7ec7\u635f\u4f24\u90fd\u4f1a\u5bfc\u81f4\u67d0\u4e9b\u708e\u75c7\u3002\u53e6\u4e00\u79cd\u7c7b\u578b\u7684\u7ec6\u80de\u6b7b\u4ea1-\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff0c\u4e5f\u88ab\u79f0\u4e3a\u51cb\u4ea1\uff08\u7b2c22\u7ae0<\/span>\uff09\u3002\u51cb\u4ea1\u8fc7\u7a0b\u53d7\u5230\u4e25\u683c\u63a7\u5236\uff0c\u4e0d\u4f1a\u50cf\u574f\u6b7b\u4e00\u6837\u6fc0\u6d3b\u8865\u4f53\u3002\u56e0\u6b64\uff0c\u7ec6\u80de\u51cb\u4ea1\u8fc7\u7a0b\u4e00\u822c\u4e0d\u4f1a\u5f15\u8d77\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u6fc0\u6d3b\u9014\u5f84\u6982\u8ff0<\/span><\/strong><\/p>\n<\/section>\n

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\u65c1\u8def\u9014\u5f84\u53ef\u6fc0\u6d3b\u4efb\u4f55\u7f3a\u4e4f\u8865\u4f53\u6291\u5236\u5242\u7684\u7ec6\u80de\u8868\u9762\u7684\u8865\u4f53\uff0c\u800c\u51dd\u96c6\u7d20\u548c\u7ecf\u5178\u9014\u5f84\u53ef\u5c06\u8865\u4f53\u6fc0\u6d3b\u805a\u7126\u4e8e\u5df2\u88abMBL\u6216\u6297\u4f53\u7ed3\u5408\u7684\u5206\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u6548\u5e94\u653e\u5927\u6b65\u9aa4<\/span><\/strong><\/p>\n<\/section>\n

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\u6bcf\u79cd\u8865\u4f53\u6210\u5206\u59cb\u7ec8\u5b58\u5728\u4e8e\u8840\u6db2\u4e2d\uff0c\u4e00\u65e6\u6fc0\u6d3b\uff0c\u4fbf\u80fd\u591f\u6fc0\u6d3b\u591a\u4e2a\u4e0b\u6e38\u6210\u5206\u3002\u8865\u4f53\u6fc0\u6d3b\u5242\u5bf9\u5c11\u91cf\u523a\u6fc0\u7269\uff08\u4f8b\u5982\u5f88\u5c11\u7684\u7ec6\u83cc\uff09\u4e5f\u8f83\u4e3a\u654f\u611f\uff0c\u968f\u540e\u7684\u6269\u589e\u6b65\u9aa4\u53ef\u786e\u4fdd\u4ea7\u751f\u5f3a\u70c8\u7684\u53cd\u5e94\uff0c\u4f46\u901a\u5e38\u662f\u5c40\u90e8\u53cd\u5e94\u3002\u8fd9\u662f\u901a\u8fc7\u6574\u4e2a\u8865\u4f53\u7ea7\u8054\uff1aC2\uff0cC3\uff0cC4\uff0cC5\u548cC6\u7684\u8865\u4f53\u7ea7\u8054\u53cd\u5e94\u83b7\u5f97\u7684\u3002\u8fd9\u4e9b\u5206\u5b50\u88ab\u88c2\u89e3\u6210\u5c0f\u7247\u6bb5\u548c\u5927\u7247\u6bb5\u800c\u88ab\u6fc0\u6d3b\uff08Fig 20.5<\/span>\uff09\u3002\u5927\u7247\u6bb5\u672c\u8eab\u53ef\u80fd\u6210\u4e3a\u9176\uff0c\u5e76\u4e14\u53ef\u4ee5\u88c2\u89e3\u5e76\u6fc0\u6d3b\u7ea7\u8054\u4e2d\u7684\u4e0b\u4e00\u4e2a\u5206\u5b50\u3002\u8fd9\u4e9b\u7247\u6bb5\u4e5f\u53ef\u4ee5\u4e0e\u6291\u5236\u6269\u589e\u6b65\u9aa4\u7684\u6291\u5236\u5242\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.5<\/span> \u5206\u88c2\u540e\uff0c\u8865\u4f53\u6210\u5206C2\u81f3C6\u7684\u7247\u6bb5\u83b7\u5f97\u9176\u6d3b\u6027\u5e76\u6fc0\u6d3b\u4e0b\u6e38\u6210\u5206<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u6548\u5e94\u5668<\/span><\/strong><\/p>\n<\/section>\n

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\u8865\u4f53\u7684\u6fc0\u6d3b\u4f1a\u4ea7\u751f\u8bb8\u591a\u6548\u5e94\u5206\u5b50\uff1a\u5982\u8fc7\u654f\u6bd2\u7d20\uff0c\u53ef\u7ed3\u5408\u548c\u6fc0\u6d3b\u8865\u4f53\u53d7\u4f53\u7684\u8865\u4f53\u7247\u6bb5\uff0c\u4ee5\u53ca\u819c\u653b\u51fb\u590d\u5408\u7269\uff08MAC\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fc7\u654f\u6bd2\u7d20<\/span><\/strong><\/p>\n<\/section>\n

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\u8865\u4f53\u7ec4\u5206C3\u548cC5\u7684\u6d3b\u5316\u53ef\u4ea7\u751f\u5c0f\u7247\u6bb5C3a\u548cC5a\u3002\u7531\u4e8e\u5b83\u4eec\u7684\u5206\u5b50\u91cf\u6bd4\u8f83\u4f4e\uff0c\u56e0\u6b64\u8fd9\u4e9b\u80bd\u53ef\u4ece\u8865\u4f53\u6fc0\u6d3b\u90e8\u4f4d\u6269\u6563\u5f00\u6765\uff0c\u5e76\u4ea7\u751f\u5982Fig 20.6<\/span>\u6240\u793a\u7684\u6548\u679c\u3002\u4f4e\u5206\u5b50\u91cf\u7684C2a\u80bd\u88c2\u89e3\u540e\u53ef\u4ee5\u4ea7\u751f\u5c0f\u6fc0\u80bd\uff0c\u53ef\u4f7f\u5185\u76ae\u7ec6\u80de\u663e\u8457\u6536\u7f29\uff0c\u4ece\u800c\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 20.6<\/span> \u8fc7\u654f\u6bd2\u7d20\u7684\u4f5c\u7528<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u53d7\u4f53<\/span><\/strong><\/p>\n<\/section>\n

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\u2022\u51e0\u79cd\u8865\u4f53\u53d7\u4f53(CRs)\u5b58\u5728\u4e8e\u591a\u79cd\u7ec6\u80de\u4e0a\uff1b\u8fd9\u4e9b\u53d7\u4f53\u7ed3\u5408\u65e9\u671f\u8865\u4f53\u6210\u5206(MBL\u3001C1\u4ee5\u53ca\u6fc0\u6d3b\u7684C4\u548cC3)\u3002CRs\u5177\u6709\u4ee5\u4e0b\u529f\u80fd\uff08Fig 20.7<\/span>\uff09\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8c03\u7406\u4f5c\u7528<\/strong>\u3002\u8fd9\u662f\u5bf9\u7ec6\u83cc\u548c\u5176\u4ed6\u7ec6\u80de\u8868\u9762\u8fdb\u884c\u4fee\u9970\u4f7f\u5176\u66f4\u52a0\u5bb9\u6613\u88ab\u541e\u566c\u7684\u8fc7\u7a0b\uff0c\u6709\u52a9\u4e8e\u5c06\u75c5\u539f\u4f53\u4e0e\u541e\u566c\u7ec6\u80de\u7ed3\u5408\u5e76\u523a\u6fc0\u541e\u566c\u4f5c\u7528\u7684\u5206\u5b50\u88ab\u79f0\u4e3a\u8c03\u7406\u7d20\u3002\u8865\u4f53\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751f\u5927\u91cf\u6d3b\u5316\u7684C3\uff0c\u5b83\u662f\u6700\u91cd\u8981\u7684\u8c03\u7406\u7d20\uff0c\u53ef\u4e0e\u4e00\u7cfb\u5217\u541e\u566c\u7ec6\u80de\u4e0a\u5b58\u5728\u7684\u4e09\u79cd\u4e0d\u540c\u53d7\u4f53\u7ed3\u5408\u3002\u5f53IgG\u4e0e\u541e\u566c\u7ec6\u80de\u4e0a\u7684Fc\u53d7\u4f53\u7ed3\u5408\u65f6\uff0c\u5b83\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u8c03\u7406\u7d20\u3002\u7531\u4e8e\u541e\u566c\u7ec6\u80de\u4e0d\u5177\u6709IgM\u7684Fc\u53d7\u4f53\uff0c\u56e0\u6b64\u5f53IgM\u53cd\u5e94\u5360\u4e3b\u5bfc\u65f6\uff0c\u8865\u4f53\u4ecb\u5bfc\u7684\u8c03\u7406\u4f5c\u7528\u5728\u521d\u6b21\u6297\u4f53\u5e94\u7b54\u671f\u95f4\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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B\u7ec6\u80de\u6fc0\u6d3b\u3002<\/strong>C3\u4e0eB\u7ec6\u80de\u4e0a\u7684CR2\u53d7\u4f53\u7684\u7ed3\u5408\u63d0\u4f9b\u4e86\u5171\u523a\u6fc0\u4f5c\u7528\uff0c\u53ef\u4f7fB\u7ec6\u80de\u6d3b\u5316\u7684\u9608\u503c\u964d\u4f4e1000\u500d\uff08Table 20.1<\/span>\uff0c\u7b2c11\u7ae0<\/span><\/a>\uff09\u3002\u56e0\u6b64\uff0c\u8865\u4f53\u4e0e\u6297\u539f\u7684\u7ed3\u5408\u53ef\u663e\u8457\u4fc3\u8fdb\u6297\u4f53\u7684\u4ea7\u751f\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4eba\u7c7bB\u7ec6\u80de\u4e0a\u7684EBV\u53d7\u4f53\u548cC3\u53d7\u4f53\u5b8c\u5168\u91cd\u53e0\uff0c\u56e0\u6b64EB\u75c5\u6bd2\u53ef\u4ee5\u7ed3\u5408CR2\uff0c\u4ece\u800c\u501f\u52a9CR2\u8fdb\u5165\u5e76\u611f\u67d3B\u7ec6\u80de\uff08\u7b2c34\u7ae0\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u514d\u75ab\u590d\u5408\u7269\u6e05\u9664\u3002<\/strong>\u514d\u75ab\u590d\u5408\u7269\u662f\u6297\u539f\u4e0e\u6297\u4f53\u7ed3\u5408\u5f62\u6210\u7684\u4e0d\u6eb6\u6027\u7269\u8d28\uff0c\u53ef\u4ee5\u5728\u7ec4\u7ec7\u6216\u8840\u6db2\u4e2d\u5f62\u6210\u3002\u8fd9\u4e9b\u590d\u5408\u7269\u4f1a\u89e6\u53d1\u708e\u75c7\uff0c\u5982\u679c\u4e0d\u53ca\u65f6\u6e05\u9664\u5b83\u4eec\uff0c\u5c31\u4f1a\u53d1\u751f\u514d\u75ab\u590d\u5408\u7269\u5f15\u8d77\u7684\u75be\u75c5\uff08\u7b2c30\u7ae0<\/span>\uff09\u3002\u8865\u4f53\u53ef\u901a\u8fc7\u4e24\u79cd\u65b9\u5f0f\u5e2e\u52a9\u53bb\u9664\u514d\u75ab\u590d\u5408\u7269\uff1a<\/p>\n

\u5927\u578b\u7684\u4e0d\u6eb6\u6027\u590d\u5408\u7269\u96be\u4ee5\u4ece\u7ec4\u7ec7\u4e2d\u53bb\u9664<\/strong>\u3002\u5927\u91cf\u6d3b\u5316\u7684C3\u53ef\u7834\u574f\u514d\u75ab\u590d\u5408\u7269\u7684\u9aa8\u67b6\uff0c\u4f7f\u5176\u6eb6\u89e3\u3002\u6eb6\u89e3\u7684\u514d\u75ab\u590d\u5408\u7269\u4e2d\u5b58\u5728\u7684C4\u548cC3\u53ef\u4ee5\u4e0e\u7ea2\u7ec6\u80de\u4e0a\u7684\u8865\u4f53\u53d7\u4f53CR1\u7ed3\u5408\uff0c\u4ece\u800c\u5c06\u514d\u75ab\u590d\u5408\u7269\u8f6c\u8fd0\u81f3\u5bcc\u542b\u541e\u566c\u7ec6\u80de\u7684\u5668\u5b98\uff0c\u4f8b\u5982\u809d\u810f\u548c\u813e\u810f\u3002\u8fd9\u4e9b\u541e\u566c\u7ec6\u80de\u53ef\u5229\u7528\u81ea\u8eab\u7684\u8865\u4f53\u548cFc\u53d7\u4f53\uff0c\u4ece\u7ea2\u7ec6\u80de\u4e2d\u6e05\u9664\u514d\u75ab\u590d\u5408\u7269\uff0c\u7136\u540e\u541e\u566c\u5e76\u7834\u574f\u514d\u75ab\u590d\u5408\u7269\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\u7ea2\u7ec6\u80de\u4e0d\u4f1a\u53d7\u5230\u4f24\u5bb3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u7f3a\u4e4f\u75c7\u60a3\u8005\u6781\u6613\u60a3\u4e0a\u7531\u514d\u75ab\u590d\u5408\u7269\u5f15\u8d77\u7684\u75be\u75c5\uff0c\u4f8b\u5982\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE, Box 20.2<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 20.7 <\/span> \u8865\u4f53\u53d7\u4f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u819c\u653b\u51fb\u6027\u590d\u5408\u7269(MAC)<\/span><\/strong><\/p>\n<\/section>\n

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\u6d3b\u5316\u7684C3\u6fc0\u6d3b\u8865\u4f53\u7ec4\u5206C5\u81f3C9\u7684\u7ea7\u8054\u53cd\u5e94\uff0c\u6700\u7ec8\u4f1a\u4ea7\u751fMAC\u3002C5\u548cC6\u5177\u6709\u9176\u6d3b\u6027\uff0c\u53ef\u4f7f\u7ec4\u5206C7\uff0cC8\u548cC9\u5d4c\u5165\u9776\u7ec6\u80de\u7684\u8d28\u819c\u3002\u4e00\u7ec410\u81f316\u4e2aC9\u5206\u5b50\u5373\u53ef\u5f62\u6210\u4e00\u4e2a\u73af\uff0c\u8be5\u73af\u5728\u8d28\u819c\u4e0a\u53ef\u5f62\u6210\u5b54\uff08Fig 20.8<\/span>\uff09\u3002\u8fd9\u79cd\u5b54\u53ef\u5141\u8bb8\u6c34\u548c\u6eb6\u8d28\u81ea\u7531\u901a\u8fc7\u819c\uff0c\u6740\u6b7b\u7ec6\u80de\u3002MAC\u53ef\u76f4\u63a5\u653b\u51fb\u75c5\u539f\u4f53\uff0c\u4f46\u5728\u4eba\u7c7b\u4e2d\u4f3c\u4e4e\u4ec5\u5bf9\u9632\u5fa1\u5948\u745f\u83cc\u8d77\u5230\u6bd4\u8f83\u91cd\u8981\u7684\u4f5c\u7528\uff08\u89c1Box 20.2<\/span>\uff09\u3002Fig 20.9<\/span>\u603b\u7ed3\u4e86\u8865\u4f53\u5982\u4f55\u53c2\u4e0e\u7ec6\u83cc\u611f\u67d3\u7684\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.8<\/span> \u5728\u88ab\u653b\u51fb\u7684\u7ec6\u80de\u8868\u9762\u5f62\u6210\u5b54\u7684C9\u5206\u5b50\u73af\u4e0e\u7a7f\u5b54\u7d20\u975e\u5e38\u76f8\u4f3c\uff0c\u7a7f\u5b54\u7d20\u662f\u4e00\u79cd\u7531\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4ea7\u751f\u7684\u7269\u8d28\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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Fig 20.9<\/span> \u8865\u4f53\u5728\u5904\u7406\u7ec6\u83cc\u611f\u67d3\u65b9\u9762\u7279\u522b\u91cd\u8981\uff0c\u4e0e\u5e72\u6270\u7d20\u6291\u5236\u75c5\u6bd2\u611f\u67d3\u6709\u4e00\u4e9b\u76f8\u4f3c\u4e4b\u5904\u3002\u8865\u4f53\u548c\u5e72\u6270\u7d20\u90fd\u53ef\u4ee5\u76f4\u63a5\u653b\u51fb\u75c5\u539f\u4f53\uff0c\u5e76\u4e14\u5404\u81ea\u5728\u56fa\u6709\u548c\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u4e2d\u62db\u52df\u4e0d\u540c\u7684\u7ec6\u80de\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8865\u4f53\u6291\u5236\u56e0\u5b50<\/span><\/strong><\/p>\n<\/section>\n

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\u8865\u4f53\u503e\u5411\u4e8e\u81ea\u53d1\u6fc0\u6d3b\uff0c\u7279\u522b\u662f\u901a\u8fc7\u65c1\u8def\u9014\u5f84\u53d1\u6325\u4f5c\u7528\u7684\u65f6\u5019\u3002\u8fc7\u5ea6\u7684\u8865\u4f53\u6fc0\u6d3b\u662f\u4e0d\u53ef\u53d6\u7684\uff0c\u56e0\u4e3a\u5b83\u4f1a\u5bfc\u81f4\u708e\u75c7\u548c\u5e7f\u6cdb\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002\u4e3a\u4e86\u9632\u6b62\u65e0\u610f\u4e2d\u6fc0\u6d3b\u8865\u4f53\uff0c\u5c31\u6709\u4e86\u8865\u4f53\u6291\u5236\u56e0\u5b50\u7684\u5b58\u5728\u3002\u5b83\u4eec\u7684\u6d3b\u52a8\u8303\u56f4\u5982Fig 20.10<\/span>\u6240\u793a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
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\u8865\u4f53\u6291\u5236\u56e0\u5b50\u7684\u7f3a\u4e4f\u4f1a\u5bfc\u81f4\u75be\u75c5\u7684\u4e8b\u5b9e\u8868\u660e\u4e86\u8fd9\u4e9b\u6291\u5236\u56e0\u5b50\u7684\u91cd\u8981\u6027\uff0c\u5728\u975e\u5178\u578b\u6eb6\u8840\u5c3f\u6bd2\u75c7\u7efc\u5408\u5f81\u5df2\u7ecf\u6709\u6240\u63cf\u8ff0\u3002\u5728\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\u4e2d\uff0cC1\u6291\u5236\u56e0\u5b50\u7684\u7a81\u53d8\u8d77\u5230\u4e86\u5173\u952e\u7684\u4f5c\u7528\uff08\u89c1Box 20.3<\/span>\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.10<\/span> \u8865\u4f53\u6291\u5236\u56e0\u5b50<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 20.1<\/span>\u6025\u6027\u671f\u54cd\u5e94<\/span><\/p>\n<\/section>\n<\/section>\n

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\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
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11\u5c81\u5973\u5b69\u56e012\u5c0f\u65f6\u7684\u8179\u75db\u548c\u5455\u5410\u53f2\u6df1\u591c\u5230\u6025\u8bca\u79d1\u5c31\u8bca\u3002\u7ecf\u67e5\uff0c\u5979\u7684\u4f53\u6e29\u548c\u8109\u640f\u6b63\u5e38(Fig 20.11<\/span>)\uff0c\u8179\u90e8\u552f\u4e00\u7684\u8ff9\u8c61\u662f\u53f3\u4fa7\u9ac2\u7a9d\u6709\u4e00\u4e9b\u89e6\u75db\u3002\u4e3b\u6cbb\u533b\u751f\u5b89\u6392\u8fdb\u884c\u4e00\u4e9b\u8840\u6db2\u6d4b\u8bd5\uff0c\u7ed3\u679c\u663e\u793a\u5728Table 20.2<\/span>\u4e2d\uff0c\u4ed6\u8ba4\u4e3a\u53ef\u80fd\u662f\u9611\u5c3e\u708e\u3002\u800c\u5973\u5b69\u5728\u8fc7\u53bb\u7684\u51e0\u4e2a\u5c0f\u65f6\u91cc\u5df2\u7ecf\u5403\u8fc7\u4e1c\u897f\uff0c\u5168\u8eab\u9ebb\u9189\u5242\u662f\u4e0d\u5b89\u5168\u7684\uff0c\u56e0\u6b64\u75c5\u4eba\u5728\u89c2\u5bdf\u75c5\u623f\u8fc7\u591c\u3002<\/p>\n

\u7b2c\u4e8c\u5929\u65e9\u4e0a\uff0c\u5979\u7684\u4f53\u6e29\u548c\u8109\u640f\u7565\u6709\u4e0a\u5347\uff0c\u62a4\u58eb\u8981\u6c42\u5916\u79d1\u533b\u751f\u5bf9\u75c5\u4eba\u8fdb\u884c\u590d\u67e5\u3002\u8179\u90e8\u75bc\u75db\u4ecd\u7136\u662f\u552f\u4e00\u7684\u4f53\u5f81\uff0c\u4f46\u91cd\u590d\u7684\u8840\u6db2\u6d4b\u8bd5\u663e\u793a\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u5347\u9ad8\uff0cC\u53cd\u5e94\u86cb\u767d(CRP)\u5347\u9ad8\uff0c\u7ea2\u7ec6\u80de\u6c89\u964d\u7387(ESR)\u5347\u9ad8\u3002\u8fd9\u4e9b\u90fd\u662f\u6025\u6027\u53cd\u5e94<\/span>\u7684\u7279\u5f81\uff0c\u4e34\u5e8a\u4e0a\u5e38\u7528\u6765\u533a\u5206\u708e\u75c7\u548c\u5176\u4ed6\u7c7b\u578b\u7684\u4e34\u5e8a\u95ee\u9898\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6025\u6027\u671f\u53cd\u5e94\u7684\u51fa\u73b0\u4f7f\u5916\u79d1\u533b\u751f\u786e\u4fe1\u4ed6\u9700\u8981\u505a\u5256\u8179\u624b\u672f\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u4ed6\u53d1\u73b0\u5e76\u5207\u9664\u4e86\u53d1\u708e\u7684\u9611\u5c3e\uff0c\u8fd9\u4e2a\u5973\u5b69\u5728\u63a5\u4e0b\u6765\u7684\u51e0\u5929\u91cc\u5eb7\u590d\u4e86\u3002<\/p>\n

\u6025\u6027\u671f\u53cd\u5e94<\/span>\u662f\u7531\u5de8\u566c\u7ec6\u80de\u91ca\u653e\u767d\u7ec6\u80de\u4ecb\u7d201(IL-1) \u767d\u7ec6\u80de\u4ecb\u7d206(IL-6)\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u89e6\u53d1\u7684\u3002\u8fd9\u4e9b\u56e0\u5b50\u90fd\u5bf9\u4e0b\u4e18\u8111\u6709\u76f4\u63a5\u7684\u5f71\u54cd(Fig 20.12<\/span>)\uff0c\u53ef\u4f7f\u4f53\u6e29\u5347\u9ad8\uff0c\u4ece\u800c\u635f\u5bb3\u75c5\u539f\u4f53\u7684\u7e41\u6b96\u3002\u8fd9\u79cd\u4f5c\u7528\u662f\u7531\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u4e0b\u4e18\u8111\u5408\u6210\u524d\u5217\u817a\u7d20\u6240\u4ecb\u5bfc\u7684\u3002\u963f\u53f8\u5339\u6797\u53ef\u4ee5\u963b\u6b62\u524d\u5217\u817a\u7d20\u7684\u5408\u6210\uff0c\u5e76\u53ef\u4ee5\u9884\u9632\u53d1\u70e7\u3002IL-1\u3001IL-6\u548cTNF\u8fd8\u53ef\u523a\u6fc0\u809d\u810f\u4ea7\u751f\u4e00\u7cfb\u5217\u86cb\u767d\u8d28\uff1a<\/p>\n

\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u5206\u5b50\uff1aC3\u3001C4\u548cCRP;<\/p>\n

\u635f\u4f24\u9650\u5236\u86cb\u767d\uff1a\u03b11-\u6297\u80f0\u86cb\u767d\u9176\u3001\u7ed3\u5408\u73e0\u86cb\u767d\uff1b<\/p>\n

\u51dd\u8840\u56e0\u5b50\uff1a\u7ea4\u7ef4\u86cb\u767d\u539f\uff1b<\/p>\n

\u6025\u6027\u53cd\u5e94<\/span>\u65f6\u4ea7\u751f\u7684\u7c92\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50(G-CSF)\u5bfc\u81f4\u9aa8\u9ad3\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u4ea7\u751f\u8fc5\u901f\u589e\u52a0\u3002\u6025\u6027\u671f\u7684\u7ec6\u80de\u56e0\u5b50\u4e5f\u6709\u52a9\u4e8e\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u666e\u904d\u6fc0\u6d3b\uff0c\u4ece\u800c\u5bfc\u81f4\u591a\u514b\u9686\u514d\u75ab\u7403\u86cb\u767d\u7684\u4ea7\u751f\u589e\u52a0\u3002<\/p>\n

CRP\u662f\u4e00\u79cd\u5728\u809d\u810f\u4e2d\u4ea7\u751f\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u4e0e\u80ba\u708e\u7403\u83cc\u7b49\u7ec6\u83cc\u8868\u9762\u7684\u78f7\u8102\u7ed3\u5408\u3002\u7136\u540e\uff0cCRP\u53d1\u6325\u8c03\u7406\u7d20\u7684\u4f5c\u7528\uff0c\u523a\u6fc0\u541e\u566c\u4f5c\u7528\u7684\u8fdb\u884c\u3002CRP\u8fd8\u53ef\u901a\u8fc7\u51dd\u96c6\u7d20\u9014\u5f84\u6fc0\u6d3b\u8865\u4f53\u7cfb\u7edf\uff0c\u5728\u708e\u75c7\u8fc7\u7a0b\u4e2d\uff0c\u7531\u4e8eTNF\u7684\u4f5c\u7528\uff0cCRP\u7684\u4ea7\u751f\u6025\u5267\u589e\u52a0\uff0c\u662f\u708e\u75c7\u7684\u4e00\u4e2a\u7279\u522b\u597d\u7684\u6307\u793a\u7269\u3002\u4f8b\u5982\uff0c\u5728\u6025\u6027\u708e\u75c7(\u5982\u9611\u5c3e\u708e)\u4e2d\uff0cCRP\u6c34\u5e73\u53ef\u5347\u9ad8\u8fbe1000\u500d\uff0c\u5207\u9664\u9611\u5c3e\u540e\uff0cCRP\u6c34\u5e73\u8fc5\u901f\u4e0b\u964d\u3002\u975e\u611f\u67d3\u6027\u75be\u75c5\u4e5f\u4f1a\u4f7fCRP\u5347\u9ad8\uff0c\u4f8b\u5982\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e–\u5b83\u4e3a\u76d1\u6d4b\u75be\u75c5\u6d3b\u52a8\u548c\u6cbb\u7597\u53cd\u5e94\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f88\u597d\u7684\u65b9\u6cd5\u3002<\/p>\n

\u4e0a\u8ff0\u86cb\u767d\u8d28\u5408\u6210\u7684\u589e\u52a0\u589e\u52a0\u4e86\u8840\u6d46\u7c98\u5ea6\uff0c\u8fd9\u53cd\u6620\u5728\u8840\u6c89\u7684\u589e\u52a0\u4e0a\u3002\u6d4b\u91cf\u8840\u6c89\u662f\u663e\u793a\u6025\u6027\u65f6\u76f8\u53cd\u5e94\u7684\u6700\u7b80\u5355\u65b9\u6cd5\u4e4b\u4e00\u3002\u5728\u708e\u75c7\u53cd\u5e94\u4e2d\uff0c\u8840\u6c89\u6bd4CRP\u9700\u8981\u66f4\u957f\u7684\u65f6\u95f4\u624d\u80fd\u53d8\u5f97\u5f02\u5e38\u3002<\/p>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Table 20.2<\/span> \u8840\u6db2\u68c0\u6d4b\u7ed3\u679c<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.11<\/span> \u8fd9\u5f20\u56fe\u8868\u663e\u793a\u4e86\u75c5\u4eba\u7684\u751f\u547d\u4f53\u5f81\u3002\u84dd\u8272\u83f1\u5f62\u4ee3\u8868\u8109\u640f\uff0c\u9ec4\u8272\u4e09\u89d2\u5f62\u4ee3\u8868\u6e29\u5ea6\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 20.12 <\/span>\u6025\u6027\u671f\u53cd\u5e94\u5bf9\u5168\u8eab\u6709\u5e7f\u6cdb\u5f71\u54cd\u3002CRP\uff0cC-\u53cd\u5e94\u86cb\u767d\uff1bIL\uff0c\u767d\u7ec6\u80de\u4ecb\u7d20\uff1bTNF\uff0c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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BOX 20.2<\/span>\u8865\u4f53\u7f3a\u4e4f\u75c7<\/span><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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\n

16\u5c81\u7537\u5b69\u5728\u6025\u8bca\u79d1\u51fa\u73b0\u4e25\u91cd\u5934\u75db\u3002\u4ed6\u88ab\u53d1\u73b0\u53d1\u70e7(\u53d1\u70e739.2\u2103\uff1b\u6b63\u5e38\u5e94\u4f4e\u4e8e37.0\u2103)\uff0c\u5e76\u6709\u660e\u663e\u7684\u9888\u90e8\u50f5\u786c\u3002\u4e3b\u6cbb\u533b\u751f\u8ba4\u4e3a\u4ed6\u53ef\u80fd\u60a3\u6709\u8111\u819c\u708e\uff0c\u5e76\u8981\u6c42\u8fdb\u884c\u8840\u6db2\u57f9\u517b\u548c\u8170\u690e\u7a7f\u523a\u3002\u8111\u810a\u6db2(CSF)\u6b63\u5e38\u5e94\u8be5\u662f\u900f\u660e\u7684\uff0c\u4f46\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5b83\u662f\u7565\u5fae\u6df7\u6d4a\u7684\u3002\u8111\u810a\u6db2\u68c0\u67e5\u663e\u793a\u4e2d\u6027\u7c92\u7ec6\u80de\u6570\u91cf\u663e\u8457\u589e\u52a0\uff0c\u5176\u4e2d\u4e00\u4e9b\u542b\u6709\u53cc\u7403\u83cc(Fig 20.13<\/span>)\u3002\u533b\u751f\u5f00\u59cb\u7ed9\u75c5\u4eba\u9759\u8109\u6ce8\u5c04\u5e7f\u8c31\u6297\u751f\u7d20\uff0c\u5728\u63a5\u4e0b\u6765\u7684\u51e0\u4e2a\u5c0f\u65f6\u91cc\uff0c\u7537\u5b69\u7684\u75c5\u60c5\u6709\u6240\u597d\u8f6c\u3002\u7b2c\u4e8c\u5929\uff0c\u8111\u810a\u6db2\u6837\u672c\u57f9\u517b\u8bc1\u5b9e\u611f\u67d3\u4e86\u8111\u819c\u708e\u5948\u745f\u83cc\u3002<\/p>\n

\u7b2c\u4e8c\u5929\uff0c\u5f53\u533b\u751f\u4e0e\u75c5\u4eba\u7684\u7236\u6bcd\u4ea4\u8c08\u65f6\uff0c\u4ed6\u53d1\u73b0\u7537\u5b69\u7684\u4e24\u4e2a\u5144\u5f1f\u59d0\u59b9\u4e5f\u611f\u67d3\u4e86\u8111\u819c\u708e\u5948\u745f\u6c0f\u83cc\u3002\u8fd9\u79cd\u5bb6\u65cf\u53f2\u662f\u5178\u578b\u7684\u9057\u4f20\u6027\u8865\u4f53\u7f3a\u4e4f\u75c7\u3002\u8fdb\u4e00\u6b65\u7684\u68c0\u6d4b\u8bc1\u5b9e\u60a3\u8005\u548c\u4ed6\u7684\u4e24\u4e2a\u53d7\u5f71\u54cd\u7684\u5144\u5f1f\u7f3a\u4e4fC8\u3002<\/p>\n

\u8865\u4f53\u6210\u5206\u7684\u7f3a\u4e4f\u4f1a\u5bfc\u81f4\u53cd\u590d\u7684\u7ec6\u83cc\u611f\u67d3\uff0c\u90e8\u5206\u539f\u56e0\u662f\u8865\u4f53\u7f3a\u4e4f\u5bfc\u81f4\u8c03\u7406\u4f5c\u7528\u51cf\u5f31\uff0c\u4f7f\u7ec6\u83cc\u4e0d\u80fd\u6709\u6548\u88ab\u541e\u566c\uff0c\u53e6\u5916\u4e00\u90e8\u5206\u539f\u56e0\u662f\u8865\u4f53\u53c2\u4e0e\u542f\u52a8\u7684\u6297\u4f53\u4ea7\u751f\u51cf\u5c11(Fig 20.14<\/span>)\u3002\u819c\u653b\u51fb\u5206\u5b50(MAC)\u7684\u7f3a\u5931\u4f1a\u5bfc\u81f4\u611f\u67d3\u5948\u745f\u6c0f\u83cc\u7684\u98ce\u9669\u66f4\u9ad8\uff0c\u5c31\u50cf\u672c\u4f8b\u4e2d\u7684\u60c5\u51b5\u4e00\u6837\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u4e3a\u4ec0\u4e48MAC\u7f3a\u9677\u7684\u4eba\u611f\u67d3\u5948\u745f\u6c0f\u83cc\u7684\u53ef\u80fd\u6027\u662f\u666e\u901a\u4eba\u7fa4\u7684\u51e0\u5343\u500d\u3002<\/p>\n

\u65e9\u671f\u51dd\u96c6\u7d20\u548c\u7ecf\u5178\u9014\u5f84\u7684\u7f3a\u9677\u4f1a\u5bfc\u81f4\u514d\u75ab\u590d\u5408\u4f53\u4e0d\u80fd\u6eb6\u89e3\u6216\u8f6c\u8fd0\u5230\u541e\u566c\u7ec6\u80de\uff0c\u4ece\u800c\u8bf1\u53d1III\u578b\u8d85\u654f\u53cd\u5e94(\u514d\u75ab\u590d\u5408\u4f53\u75be\u75c5)(\u7b2c30\u7ae0<\/span>)\u3002\u65e9\u671f\u8865\u4f53\u6210\u5206\u7f3a\u4e4f\u53ef\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae(SLE)\u3002<\/p>\n

\u8865\u4f53\u6c34\u5e73\u4f4e\u901a\u5e38\u662f\u809d\u810f\u4e2d\u8865\u4f53\u6210\u5206\u6d88\u8017\u8fc7\u591a\u800c\u4e0d\u662f\u4ea7\u751f\u51cf\u5c11\u5bfc\u81f4\u7684\u3002\u8865\u4f53\u5728\u514d\u75ab\u590d\u5408\u7269\u4ea7\u751f\u65f6\u4f1a\u88ab\u6d88\u8017\uff0c\u4f8b\u5982\u5728\u611f\u67d3\u65f6\u6216\u5728\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 20.13<\/span> \u60a3\u8005\u8111\u810a\u6db2(CSF)\u9769\u5170\u6c0f\u67d3\u8272\u3002\u6b63\u5e38\u8111\u810a\u6db2\u542b\u6709\u8f83\u5c11\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u8fd9\u5f20\u56fe\u7247\u4e2d\u7684\u4e09\u4e2a\u4e2d\u6027\u7c92\u7ec6\u80de\u541e\u566c\u4e86\u8111\u819c\u708e\u5948\u745f\u6c0f\u83cc\u3002\u541e\u566c\u5948\u745f\u6c0f\u83cc\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u7a81\u51fa\u663e\u793a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

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\n

Fig 20.4 <\/span>\u8865\u4f53\u7f3a\u4e4f\u75c7\u7684\u4e34\u5e8a\u7279\u5f81\u53d6\u51b3\u4e8e\u54ea\u4e9b\u6210\u5206\u7f3a\u5931<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
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BOX 20.3 <\/span>\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf<\/span><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
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20\u5c81\u7537\u5b50\u591a\u6b21\u51fa\u73b0\u9762\u90e8\u80bf\u80c0\u548c\u4e0d\u660e\u539f\u56e0\u7684\u5267\u70c8\u8179\u75db(Fig 20.15<\/span>)\u3002\u5728\u4e00\u573a\u6bd4\u8d5b\u68c0\u67e5\u4e2d\u53d1\u73b0\u4ed6\u7684\u8865\u4f53C4\u6c34\u5e73\u8f83\u4f4e\uff0c\u800cC3\u662f\u6b63\u5e38\u7684\u3002\u5bf9\u5176\u4e2d\u4e00\u4e2a\u6837\u54c1\u8fdb\u884c\u4e86C1\u6291\u5236\u56e0\u5b50\u6c34\u5e73\u7684\u5206\u6790\uff0c\u53d1\u73b0\u5176\u6c34\u5e73\u975e\u5e38\u4f4e\uff0c\u6545\u8bca\u65ad\u4e3a\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\uff0c\u8fd9\u4e00\u6b21\u4ed6\u63a5\u53d7\u4e86\u7eaf\u5316\u7684C1\u6291\u5236\u5242\u6cbb\u7597\uff0c\u80bf\u80c0\u51e0\u4e2a\u5c0f\u65f6\u540e\u5c31\u6d88\u9000\u4e86\u3002<\/p>\n

\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\u662f\u4e00\u79cd\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u6027\u75be\u75c5\uff0c\u7531C1\u6291\u5236\u56e0\u5b50\u7f3a\u4e4f\u5f15\u8d77\uff0cC1\u6291\u5236\u56e0\u5b50\u662f\u4e00\u79cd\u540d\u4e3a\u4e1d\u6c28\u9178\u86cb\u767d\u9176\u6291\u5236\u5242\u7684\u8840\u6d46\u86cb\u767d\u5bb6\u65cf\u6210\u5458\u3002C1\u6291\u5236\u56e0\u5b50\u7684\u7f3a\u4e4f\u610f\u5473\u7740\u65e9\u671f\u8865\u4f53\u7ea7\u8054\u975e\u5e38\u5bb9\u6613\u88ab\u6fc0\u6d3b\u3002\u8865\u4f53\u7ea7\u8054\u7684\u6fc0\u6d3b\u5728C3\u6c34\u5e73\u4e0a\u505c\u6b62\uff0c\u56e0\u4e3a\u7f3a\u5c11\u5408\u9002\u7684\u8865\u4f53\u6fc0\u6d3b\u8868\u9762\u3002C4\u548cC2\u5728\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\u88ab\u88c2\u89e3\uff0c\u5e76\u4ea7\u751f\u8fc7\u91cf\u7684C2a\u6fc0\u80bd\u3002C1\u6291\u5236\u56e0\u5b50\u901a\u5e38\u4e5f\u4f1a\u6291\u5236\u6fc0\u80bd\u539f\u4ea7\u751f\u53e6\u4e00\u79cd\u6fc0\u80bd–\u7f13\u6fc0\u80bd\u3002\u5728\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\u7684\u60a3\u8005\u4e2d\uff0c\u8865\u4f53\u548c\u6fc0\u80bd\u7684\u6fc0\u6d3b\u7531\u8f7b\u5fae\u7684\u89e6\u53d1\u56e0\u7d20(\u5982\u521b\u4f24\u3001\u611f\u67d3\uff0c\u751a\u81f3\u5fc3\u7406\u538b\u529b)\u5f15\u8d77\uff0cC1\u6291\u5236\u56e0\u5b50\u65e0\u6cd5\u6291\u5236\u3002\u5176\u7ed3\u679c\u662f\u8fc7\u91cf\u7684C2a\u6fc0\u52a8\u7d20\u548c\u7f13\u6fc0\u80bd\u7684\u4ea7\u751f\uff0c\u5bfc\u81f4\u6240\u6709\u90e8\u4f4d\u7684\u6bdb\u7ec6\u8840\u7ba1\u901a\u900f\u6027\u589e\u52a0\uff0c\u5f15\u8d77\u75bc\u75db\u7684\u80bf\u80c0\uff0c\u6709\u65f6\u751a\u81f3\u5371\u53ca\u751f\u547d\u3002<\/p>\n

\u7eaf\u5316\u7684C1\u6291\u5236\u56e0\u5b50\u53ef\u9884\u9632\u548c\u6cbb\u7597\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf\u7684\u53d1\u4f5c\u3002\u53e6\u4e00\u79cd\u9009\u62e9\u662f\u7ed9\u4e88\u5408\u6210\u7c7b\u56fa\u9187\uff0c\u8fd9\u53ef\u4ee5\u589e\u52a0C1\u6291\u5236\u56e0\u5b50\u7684\u6c34\u5e73\u3002<\/p>\n

\u53e6\u4e00\u79cd\u91cd\u8981\u7684\u4e1d\u86cb\u767d\u662f\u03b11-\u6297\u80f0\u86cb\u767d\u9176\uff0c\u5b83\u901a\u5e38\u4f1a\u91ca\u653e\u541e\u566c\u7ec6\u80de\u91ca\u653e\u7684\u86cb\u767d\u9176\u3002\u9057\u4f20\u03b1-1-\u6297\u80f0\u86cb\u767d\u9176\u57fa\u56e0\u5f02\u5e38\u7684\u60a3\u8005\u4f1a\u60a3\u4e0a\u80ba\u6c14\u80bf(\u86cb\u767d\u6c34\u89e3\u9176\u7684\u975e\u5bf9\u6297\u6027\u4f5c\u7528\u9020\u6210\u7684\u80ba\u7834\u574f)\u548c\u809d\u75c5(\u7531\u5f02\u5e38\u7684\u03b1-1-\u6297\u80f0\u86cb\u767d\u9176\u5206\u5b50\u79ef\u805a\u5f15\u8d77)\u3002<\/p>\n<\/section>\n<\/section>\n

\n
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Fig 20.15<\/span>  \u75c5\u4eba\u6b63\u5e38\u5916\u89c2\uff0c\u4ee5\u53ca\u4ed6\u5728\u8840\u7ba1\u6027\u6c34\u80bf\u53d1\u4f5c\u671f\u95f4\u7684\u6837\u5b50<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u674e\u6f84\u7199 \u5f20\u7ef4\u658c \u5f90\u66fc\u65af<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u949f\u96ea\u83b9<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u5b8b\u4e50 \u9648\u79cb\u8c37<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n


<\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c19\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u751f\u7406\u529f\u80fd\u7b80\u8ff0<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5373\u5c06\u5f00\u59cb\uff0c\u656c\u8bf7\u671f\u5f85\uff01<\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/span><\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
<\/p>\n

Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
<\/p>\n

BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
<\/p>\n

\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
<\/p>\n

HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
<\/p>\n

PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
<\/p>\n

Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
<\/p>\n

\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
<\/p>\n

PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n

\u5065\u5eb7\u517b\u751f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u516b\u6bb5\u9526\uff08\u89c6\u9891\u7248+\u56fe\u7247\u7248\uff0c\u63a8\u8350\u6536\u85cf\uff09<\/span><\/a>
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\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n


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<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u80fd\u591f\u7a81\u7834\u4eba\u4f53\u7269\u7406\u5c4f\u969c\u7684\u611f\u67d3\u4f1a\u6fc0\u6d3b\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7684\u5206\u5b50\u5c4f\u969c\uff0c\u5176\u4e2d\u5305\u62ec\u5e72\u6270\u7d20\u7cfb\u7edf\u548c\u8865\u4f53\u7cfb\u7edf\u3002 \u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u7531…<\/p>\n","protected":false},"author":1,"featured_media":1889,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[64],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1890"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=1890"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1890\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/1889"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=1890"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=1890"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=1890"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}