{"id":1894,"date":"2021-09-16T23:33:23","date_gmt":"2021-09-16T15:33:23","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2021\/09\/16\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e6%9d%80%e4%bc%a4%e5%8a%9f%e8%83%bd\/"},"modified":"2021-09-16T23:33:23","modified_gmt":"2021-09-16T15:33:23","slug":"%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e6%9d%80%e4%bc%a4%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2021\/09\/16\/%e5%85%8d%e7%96%ab%e5%ad%a6%e6%8b%be%e9%81%97-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%85%8d%e7%96%ab%e7%b3%bb%e7%bb%9f%e7%9a%84%e6%9d%80%e4%bc%a4%e5%8a%9f%e8%83%bd\/","title":{"rendered":"\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c22\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u529f\u80fd"},"content":{"rendered":"
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<\/section>\n<\/section>\n
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\u63d2\u64ad\u4e00\u6761\u5e7f\u544a\uff0c\u672c\u5b9e\u9a8c\u5ba4\u6709\u57fa\u7840\u533b\u5b66(\u514d\u75ab\u5b66)\u7814\u7a76\u751f\u62db\u751f\u540d\u989d\u5c11\u91cf(\u53ef\u63a5\u53d7\u63a8\u514d)\uff0c\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u501f\u52a9\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f\u63a2\u7d22\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5bfc\u81f4\u514d\u75ab\u9003\u9038\u7684\u56e0\u7d20\u4ee5\u53ca\u901a\u8fc7\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u6709\u5174\u8da3\u7684\u53ef\u4ee5\u8054\u7cfb\u6211\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bfc \u8bfb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u6d88\u706d\u5404\u79cd\u5404\u6837\u7684\u75c5\u539f\u4f53\u3002Table<\/span><\/span>21.1<\/span>\u63cf\u8ff0\u4e86\u8865\u4f53\u548c\u541e\u566c\u7ec6\u80de\u6d88\u706d\u7ec6\u80de\u5916\u75c5\u539f\u4f53\u7684\u8fc7\u7a0b\u3002\u514d\u75ab\u7cfb\u7edf\u53ef\u5229\u7528\u4e0a\u56fe\u6240\u793a\u7684\u673a\u5236\uff0c\u901a\u8fc7\u80a5\u5927\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u6d88\u706d\u5bc4\u751f\u866b\u548c\u75c5\u6bd2\u8fd9\u4e24\u79cd\u7279\u6b8a\u7c7b\u578b\u7684\u75c5\u539f\u4f53\u3002\u672c\u7ae0\u66f4\u52a0\u8be6\u7ec6\u5730\u63cf\u8ff0\u4e86\u7ec6\u80de\u51cb\u4ea1\u8fd9\u4e00\u514d\u75ab\u7cfb\u7edf\u901a\u7528\u7684\u6740\u4f24\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table22.1 <\/span>\u4e0d\u540c\u7684\u75c5\u539f\u4f53\u53ef\u6fc0\u6d3b\u4e0d\u540c\u7684\u514d\u75ab\u53d7\u4f53<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u5bc4\u751f\u866b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bc4\u751f\u866b\u662f\u4eba\u7c7b\u8fdb\u5316\u8fc7\u7a0b\u7684\u4e00\u4e2a\u91cd\u8981\u5a01\u80c1\u3002\u7531\u4e8e\u536b\u751f\u6761\u4ef6\u7684\u6539\u5584\uff0c\u5bf9\u4e8e\u53d1\u8fbe\u56fd\u5bb6\u7684\u4eba\u4eec\u6765\u8bf4\u8fd9\u4e0d\u518d\u662f\u4e00\u4e2a\u4e25\u91cd\u7684\u95ee\u9898\uff0c\u4f46\u4e16\u754c\u4e0a\u4ecd\u6709\u4e09\u5206\u4e4b\u4e00\u7684\u4eba\u53e3\u9762\u4e34\u5bc4\u751f\u866b\u95ee\u9898\u7684\u5a01\u80c1\u3002\u5bc4\u751f\u866b\u6709\u5404\u79cd\u5404\u6837\u7684\u5f62\u72b6\u548c\u5927\u5c0f\uff08\u4ece1\u6beb\u7c73\u523010m\uff09\uff0c\u5e76\u4e14\u751f\u547d\u5468\u671f\u6bd4\u8f83\u590d\u6742\uff0c\u5305\u62ec\u5375\uff0c\u5e7c\u866b\u548c\u6210\u866b\u4e09\u4e2a\u9636\u6bb5\u3002\u866b\u5375\u80fd\u62b5\u5fa1\u80c3\u4e2d\u7684\u4f4epH\u503c\u4ee5\u53ca\u86cb\u767d\u8d28\u7684\u5206\u89e3\u6d88\u5316\uff0c\u76f4\u5230\u5230\u8fbe\u4e0b\u80a0\u9053\u5b83\u4eec\u624d\u4f1a\u5b75\u5316\u3002\u4e0b\u90e8\u80a0\u9053\u4e3a\u6210\u866b\u63d0\u4f9b\u4e86\u4fdd\u62a4\uff0c\u4f7f\u5176\u514d\u53d7\u8bb8\u591a\u514d\u75ab\u53cd\u5e94\u6210\u5206\u7684\u5f71\u54cd\u3002\u4e3a\u514b\u670d\u8fd9\u4e2a\u95ee\u9898\uff0c\u80a5\u5927\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u5df2\u7ecf\u8fdb\u5316\u4e3a\u80fd\u591f\u5bf9\u751f\u6d3b\u5728\u80a0\u9053\u4e2d\u7684\u8815\u866b\u4ea7\u751f\u53cd\u5e94\uff08Fig 22.1<\/span>\uff09\u3002\u8fd9\u4e9b\u7ec6\u80de\u88ab\u6fc0\u6d3b\u540e\u53ef\u5c06\u6709\u6bd2\u7269\u8d28\u6392\u653e\u81f3\u80a0\u8154\u4e2d\uff0c\u589e\u52a0\u7c98\u6db2\u5206\u6ccc\uff0c\u5f15\u8d77\u5e73\u6ed1\u808c\u6536\u7f29\uff0c\u4ece\u800c\u9a71\u9664\u8815\u866b\u3002Fig22.2<\/span>\u603b\u7ed3\u4e86\u8fd9\u4e9b\u53cd\u5e94\u3002\u547c\u5438\u9053\u4e2d\u4e5f\u8fdb\u5316\u51fa\u4e86\u76f8\u540c\u7684\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.1 <\/span>\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u76ee\u6807<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.2<\/span> \u514d\u75ab\u7cfb\u7edf\u5bf9\u80a0\u9053\u5bc4\u751f\u866b\u7684\u5e94\u7b54<\/span><\/p>\n

       IgE\uff0c\u514d\u75ab\u7403\u86cb\u767dE\uff1bTH\uff0cT\u8f85\u52a9\u7ec6\u80de<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80a5\u5927\u7ec6\u80de<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u80a5\u5927\u7ec6\u80de\u6765\u6e90\u4e8e\u9aa8\u9ad3\u4e2d\u4e00\u79cd\u672a\u77e5\u7684\u524d\u4f53\u7ec6\u80de\uff0c\u53d7\u8f85\u52a9\u6027T\u7ec6\u80de2(TH2)\u6240\u5206\u6ccc\u7684\u7ec6\u80de\u56e0\u5b50\u5982\u767d\u7ec6\u80de\u4ecb\u7d20(IL)-3\u548cIL-4\u7684\u5f71\u54cd\u3002\u50cf\u5de8\u566c\u7ec6\u80de\u4e00\u6837\uff0c\u80a5\u5927\u7ec6\u80de\u5b58\u5728\u4e8e\u4e00\u7cfb\u5217\u6b63\u5e38\u7ec4\u7ec7\uff0c\u5305\u62ec\u7c98\u819c\u4e0b\u5c42\uff0c\u76ae\u80a4\u548c\u7ed3\u7f14\u7ec4\u7ec7\uff08Fig 22.3<\/span>\uff09\u3002\u5bc4\u751f\u866b\u611f\u67d3\u671f\u95f4\u8fd9\u4e9b\u7ec4\u7ec7\u4e2d\u52df\u96c6\u7684\u80a5\u5927\u7ec6\u80de\u6570\u91cf\u4f1a\u663e\u8457\u589e\u52a0\uff0c\u80a5\u5927\u7ec6\u80de\u4f1a\u5728\u7ec4\u7ec7\u4e2d\u505c\u7559\u6570\u5468\uff0c\u8fd9\u6bb5\u65f6\u95f4\u5185\u5b83\u4eec\u4f1a\u4ea7\u751f\u5305\u542b\u591a\u79cd\u4ecb\u8d28\u7684\u9897\u7c92\u3002\u80a5\u5927\u7ec6\u80de\u7279\u6b8a\u7684Fc\u53d7\u4f53\uff08Fc\u03b5RI\uff09\u80fd\u4e0e\u514d\u75ab\u7403\u86cb\u767dE\uff08IgE\uff09\u7ed3\u5408\uff0c\u8be5\u53d7\u4f53\u5bf9IgE\u7684\u4eb2\u548c\u529b\u975e\u5e38\u9ad8\uff0c\u5373\u4f7f\u4eba\u4f53\u5176\u4ed6\u90e8\u4f4d\u4ea7\u751f\u7684IgE\u6c34\u5e73\u5f88\u4f4e\uff0c\u4e5f\u80fd\u4e0e\u80a5\u5927\u7ec6\u80de\u7ed3\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u6b64\uff0c\u80a5\u5927\u7ec6\u80de\u53ef\u4ee5\u7ed3\u5408\u4e00\u7cfb\u5217\u9488\u5bf9\u591a\u79cd\u4e0d\u540c\u6297\u539f\u7684IgE\u5206\u5b50\uff08Table  22.1<\/span>\uff09\u3002\u5f53\u8fd9\u4e9b\u8868\u9762IgE\u5206\u5b50\u4e0e\u6297\u539f\u4ea4\u8054\u65f6\uff0c\u80a5\u5927\u7ec6\u80de\u5c31\u4f1a\u88ab\u6fc0\u6d3b\uff08Fig 22.4<\/span>\uff09\u3002\u80a5\u5927\u7ec6\u80de\u7684Fc\u03b5RIs\u4e0d\u540c\u4e8e\u5176\u4ed6\u7c7b\u578b\u7684Fc\u53d7\u4f53\uff0c\u5b83\u4eec\u7ed3\u5408\u6ca1\u6709\u4e0e\u6297\u539f\u7ed3\u5408\u7684Ig\uff0c\u5e76\u4e14\u76f4\u5230\u5b83\u4eec\u88ab\u6297\u539f\u4ea4\u8054\u624d\u4f1a\u88ab\u6fc0\u6d3b\u3002\u80a5\u5927\u7ec6\u80de\u4e5f\u80fd\u88ab\u8fc7\u654f\u6bd2\u7d20C3a\u548cC5a\uff08\u7b2c20\u7ae0<\/span>\uff09\u548c\u4e00\u4e9b\u836f\u7269\u6fc0\u6d3b\u3002\u80a5\u5927\u7ec6\u80de\u6fc0\u6d3b\u4f1a\u5bfc\u81f4\u8131\u9897\u7c92\u4f5c\u7528\uff0c\u91ca\u653e\u4e4b\u524d\u5f62\u6210\u7684\u7269\u8d28\uff0c\u4ee5\u53ca\u6fc0\u6d3b\u82b1\u751f\u56db\u70ef\u9178\u4ee3\u8c22\u4ee5\u4ea7\u751f\u4e00\u7cfb\u5217\u65b0\u5408\u6210\u7684\u4ecb\u8d28\uff08Table 22.2<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.3 <\/span>\u80a5\u5927\u7ec6\u80de\u3002\u80a5\u5927\u7ec6\u80de\u4e2d\u7684\u9897\u7c92\u542b\u6709\u7ec6\u80de\u56e0\u5b50\u3001\u7ec4\u80fa\u548c\u86cb\u767d\u6c34\u89e3\u9176\u3002Fc\u03b5RI\uff0cFc\u53d7\u4f53\uff1bIg\uff0c\u514d\u75ab\u7403\u86cb\u767d\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table22.2 <\/span>\u80a5\u5927\u7ec6\u80de\u4ecb\u8d28<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.4 <\/span>\u80a5\u5927\u7ec6\u80de\u7684\u6fc0\u6d3b<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9897\u7c92\u4e2d\u5305\u542b\u7684\u7269\u8d28<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u80a5\u5927\u7ec6\u80de\u9176<\/strong><\/p>\n<\/section>\n

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\u80a5\u5927\u7ec6\u80de\u9897\u7c92\u542b\u6709\u8bb8\u591a\u86cb\u767d\u6c34\u89e3\u9176\uff0c\u5305\u62ec\u7c7b\u80f0\u86cb\u767d\u9176\u548c\u80f0\u51dd\u4e73\u86cb\u767d\u9176\u3002\u8fd9\u4e9b\u9176\u53ef\u589e\u52a0\u652f\u6c14\u7ba1\u4e2d\u7684\u7c98\u6db2\u5206\u6ccc\u548c\u5e73\u6ed1\u808c\u6536\u7f29\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u8fd8\u53ef\u88c2\u89e3\u548c\u6fc0\u6d3b\u8865\u4f53\u4ee5\u53ca\u6fc0\u80bd\u9014\u5f84\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u4ece\u800c\u4fc3\u8fdb\u708e\u75c7\u3002\u8840\u4e2d\u80a5\u5927\u7ec6\u80de\u7c7b\u80f0\u86cb\u767d\u9176\u6c34\u5e73\u53ef\u7528\u4e8e\u4e25\u91cd\u8fc7\u654f\u53cd\u5e94\u7684\u8bca\u65ad\uff08Box22.1<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec4\u80fa<\/strong><\/p>\n<\/section>\n

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\u7ec4\u80fa\u53ef\u901a\u8fc7\u5f15\u8d77\u80a0\u9053\u548c\u80ba\u90e8\u5e73\u6ed1\u808c\u6536\u7f29\u6765\u9a71\u9664\u5bc4\u751f\u866b\uff0c\u5e76\u4e14\u80fd\u901a\u8fc7\u5f15\u8d77\u5185\u76ae\u7ec6\u80de\u6536\u7f29\u800c\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\uff0c\u6269\u5927\u7ec6\u80de\u95f4\u9699\uff0c\u4e4b\u540e\u5bfc\u81f4\u7ec4\u7ec7\u6c34\u80bf\u3002\u7ec4\u80fa\u8fd8\u80fd\u591f\u63d0\u4f9b\u8d8b\u5316\u4fe1\u53f7\u5c06\u66f4\u591a\u7684\u767d\u7ec6\u80de\u5438\u5f15\u5230\u5bc4\u751f\u866b\u611f\u67d3\u90e8\u4f4d\uff0c\u8fd8\u4f1a\u5f15\u8d77\u76ae\u80a4\u660e\u663e\u7684\u7619\u75d2\uff0c\u5f15\u8d77\u611f\u67d3\u7684\u5bbf\u4e3b\u5bf9\u76ae\u80a4\u5bc4\u751f\u866b\u7684\u6ce8\u610f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u56e0\u5b50<\/strong><\/p>\n<\/section>\n

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\u50cf\u6d3b\u5316\u7684\u5de8\u566c\u7ec6\u80de\u4e00\u6837\uff0c\u80a5\u5927\u7ec6\u80de\u80fd\u591f\u4ea7\u751f\u4e00\u7cfb\u5217\u7684\u7ec6\u80de\u56e0\u5b50\u6765\u4fc3\u8fdb\u548c\u5ef6\u957f\u708e\u75c7\u53cd\u5e94\u3002\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\u662f\u9884\u5148\u5f62\u6210\u5e76\u5b58\u5728\u4e8e\u9897\u7c92\u4e2d\u7684\uff0c\u5b83\u53ef\u6fc0\u6d3b\u5c40\u90e8\u5185\u76ae\u7ec6\u80de\uff0c\u4fc3\u8fdb\u66f4\u591a\u708e\u75c7\u7ec6\u80de\u7684\u6e17\u51fa\u3002\u80a5\u5927\u7ec6\u80de\u5728\u53d7\u5230\u523a\u6fc0\u540e\u8fd8\u53ef\u4ea7\u751f\u5176\u4ed6\u7ec6\u80de\u56e0\u5b50\uff0c\u4e0e\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\u4e0d\u540c\uff0c\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u80fd\u591f\u523a\u6fc0TH2\u53cd\u5e94\u3002\u5982IL-4\u53ef\u6fc0\u6d3bTH2\u7ec6\u80de\uff0cIL-3\u548cIL-5\u53ef\u523a\u6fc0\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u4ea7\u751f\u548c\u6fc0\u6d3b\u3002IL-4\u548cIL-5\u4e5f\u4f1a\u4f7f\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u504f\u79bbTH1\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u82b1\u751f\u56db\u70ef\u9178\u4ee3\u8c22\u4ea7\u7269<\/strong><\/p>\n<\/section>\n

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\u82b1\u751f\u56db\u70ef\u9178\u4ee3\u8c22\u4ea7\u7269\u7531\u80a5\u5927\u7ec6\u80de\u548c\u541e\u566c\u7ec6\u80de\u4ea7\u751f\u5e76\u901a\u8fc7\u80a5\u5927\u7ec6\u80de\u4e0e\u6297\u539f\u7ed3\u5408\u6fc0\u6d3b\uff0c\u4e00\u822c\u9075\u5faa\u4e24\u79cd\u4e0d\u540c\u7684\u9014\u5f84\uff08Fig22.5<\/span>\uff09\uff1a<\/p>\n

1.\u73af\u6c27\u5408\u9176\u9014\u5f84\u4ea7\u751f\u524d\u5217\u817a\u7d20\u3002\u5b83\u4eec\u53ef\u5728\u51e0\u79d2\u949f\u5185\u8d77\u4f5c\u7528\uff0c\u523a\u6fc0\u8840\u7ba1\u6269\u5f20\uff0c\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\uff0c\u5e76\u6536\u7f29\u80a0\u548c\u652f\u6c14\u7ba1\u7684\u5e73\u6ed1\u808c\u3002\u524d\u5217\u817a\u7d20\u8fd8\u6709\u5176\u4ed6\u8f83\u6162\u7684\u4f5c\u7528\uff0c\u4f8b\u5982\u6291\u5236TH1\u7ec6\u80de\u3002<\/p>\n

2.\u8102\u6c27\u5408\u9176\u9014\u5f84\u4ea7\u751f\u767d\u4e09\u70ef\u3002\u4e0e\u524d\u5217\u817a\u7d20\u76f8\u6bd4\uff0c\u767d\u4e09\u70ef\u7684\u4f5c\u7528\u8981\u6162\u5f97\u591a\uff0c\u4f46\u6709\u52a9\u4e8e\u652f\u6c14\u7ba1\u548c\u80a0\u9053\u5e73\u6ed1\u808c\u7684\u6536\u7f29\u3002\u53e6\u5916\uff0c\u767d\u4e09\u70ef\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8d77\u8d8b\u5316\u523a\u6fc0\u4f5c\u7528\uff0c\u56e0\u6b64\u6709\u52a9\u4e8e\u589e\u52a0\u5373\u65f6\u53cd\u5e94\u7684\u7ec6\u80de\u5bc6\u5ea6\uff0c\u5e76\u5c06\u5176\u8f6c\u5316\u4e3a\u5ef6\u8fdf\u6216\u6162\u6027\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80a5\u5927\u7ec6\u80de\u5b58\u5728\u4e8e\u8bb8\u591a\u5bc4\u751f\u866b\u611f\u67d3\u7684\u7ec4\u7ec7\u4e2d\u3002\u5c3d\u7ba1\u80a5\u5927\u7ec6\u80de\u7684\u6fc0\u6d3b\u4f9d\u8d56\u4e8e\u9884\u5148\u5f62\u6210\u7684IgE\u6297\u4f53\uff0c\u4f46\u5b83\u4eec\u5bf9\u6297\u539f\u523a\u6fc0\u7684\u53cd\u5e94\u975e\u5e38\u8fc5\u901f\u3002\u7ec4\u80fa\u3001\u86cb\u767d\u6c34\u89e3\u9176\u548c\u524d\u5217\u817a\u7d20\u5f15\u8d77\u5373\u65f6\u53cd\u5e94\uff0c\u5305\u62ec\u5e73\u6ed1\u808c\u6536\u7f29\u3001\u8840\u7ba1\u901a\u900f\u6027\u589e\u52a0\u548c\u7c98\u6db2\u5206\u6ccc\u3002\u7ec6\u80de\u56e0\u5b50\u548c\u767d\u4e09\u70ef\u4fc3\u8fdb\u5bf9\u6297\u539f\u7684\u665a\u671f\u53cd\u5e94\uff0c\u671f\u95f4\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u548cTH2\u7ec6\u80de\u5927\u91cf\u6d8c\u5165\u3002\u8fd9\u79cd\u665a\u671f\u708e\u75c7\u53ef\u80fd\u4f1a\u8f6c\u4e3a\u6162\u6027\u708e\u75c7\uff0c\u4f46\u4e0e\u8089\u82bd\u80bf\u4e0d\u540c\uff0c\u8089\u82bd\u80bf\u7684\u7279\u5f81\u662f\u5de8\u566c\u7ec6\u80de\u548cTH1\u7ec6\u80de\u7684\u5b58\u5728\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.5<\/span> \u82b1\u751f\u56db\u70ef\u9178\u4ee3\u8c22<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u55dc\u9178\u6027\u7c92\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u4e0e\u80a5\u5927\u7ec6\u80de\u5927\u4f53\u76f8\u4f3c\u3002\u4f46\u662f\uff0c\u6709\u4e24\u4e2a\u56e0\u7d20\u4f7f\u5b83\u4eec\u72ec\u4e00\u65e0\u4e8c\uff1a1\uff09\u67d0\u4e9b\u708e\u75c7\u8fc7\u7a0b\u4e2d\u5b83\u4eec\u88ab\u7279\u5f02\u6027\u5730\u52df\u96c6\u5230\u7ec4\u7ec7\u4e2d \uff1b2\uff09\u5b83\u4eec\u7684\u9897\u7c92\u542b\u6709\u6bd2\u6027\u7269\u8d28<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6765\u6e90\u4e8e\u7c7b\u4f3c\u4e8e\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u524d\u4f53\uff0c\u5e76\u4e14\u53d7\u5230IL-3\u548cIL-5\u7684\u523a\u6fc0\u3002<\/span>\u8840\u6db2\u4e2d\u7684\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8f83\u5c11\uff0c\u4f46\u662f\u5b83\u4eec\u7684\u6570\u91cf\u4f1a\u968f\u7740TH2\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u5206\u6ccc\u7684IL-3\u548cIL-5\u7684\u589e\u52a0\u800c\u6025\u5267\u589e\u52a0\u3002Box22.2<\/span>\u8ba8\u8bba\u4e86\u8840\u6db2\u4e2d\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6570\u91cf\u589e\u52a0\u7684\u539f\u56e0\uff0c\u5176\u88ab\u79f0\u4e3a\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u75c7\u3002\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8d8b\u5316\u56e0\u5b50\u5c06\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u52df\u96c6\u5230\u5bc4\u751f\u866b\u611f\u67d3\u7684\u90e8\u4f4d\uff0c\u8fd9\u79cd\u8d8b\u5316\u56e0\u5b50\u662f\u7531\u4e0a\u76ae\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u4ea7\u751f\u7684\u767d\u4e09\u70ef\u4ea7\u751f\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u80fd\u88ab\u7ec6\u80de\u56e0\u5b50\uff0c\u8d8b\u5316\u56e0\u5b50\u6fc0\u6d3b\uff0c\u8fd8\u80fd\u88abFc\u03b5RI\u4e0a\u7684\u4ea4\u8054IgE\u6fc0\u6d3b\u3002\u6d3b\u5316\u7684\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u9664\u91ca\u653e\u51fa\u4e0e\u80a5\u5927\u7ec6\u80de\u76f8\u540c\u7684\u4ecb\u8d28\uff08\u9664\u7ec4\u80fa\u5916\uff09\uff0c\u8fd8\u91ca\u653e\u4e09\u79cd\u7279\u6b8a\u4ecb\u8d28\uff1a<\/p>\n

1.\u8fc7\u6c27\u5316\u7269\u9176\uff0c\u91ca\u653e\u5230\u5bc4\u751f\u866b\u7684\u8868\u9762\uff0c\u7136\u540e\u751f\u6210\u6b21\u6c2f\u9178<\/p>\n

2.\u4e3b\u8981\u78b1\u6027\u86cb\u767d\u8d28\uff0c\u4f1a\u7834\u574f\u5bc4\u751f\u866b\u7684\u5916\u8868\u9762\u548c\u5bbf\u4e3b\u7ec4\u7ec7<\/p>\n

3.\u9633\u79bb\u5b50\u86cb\u767d\uff0c\u5b83\u4f1a\u7834\u574f\u5bc4\u751f\u866b\u7684\u5916\u8868\u9762\u5e76\u5145\u5f53\u795e\u7ecf\u6bd2\u7d20\uff0c\u7834\u574f\u5bc4\u751f\u866b\u7684\u7b80\u5355\u795e\u7ecf\u7cfb\u7edf<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u901f\u53d1\u578b\uff08I\u578b\uff09\u8d85\u654f\u53cd\u5e94<\/strong><\/p>\n<\/section>\n

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\u56e0\u4e3a\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u8131\u9897\u7c92\u7684\u5f71\u54cd\u975e\u5e38\u5feb\uff0c\u6240\u4ee5\u8fd9\u79cd\u7c7b\u578b\u7684\u53cd\u5e94\u6709\u65f6\u88ab\u79f0\u4e3a\u901f\u53d1\u578b\u8d85\u654f\u53cd\u5e94\uff0c\u5c3d\u7ba1\u91ca\u653e\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u5176\u4ed6\u4ecb\u8d28\u4e5f\u53ef\u4ee5\u5f15\u8d77\u8fdf\u53d1\u6027\u548c\u6162\u6027\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u751f\u6d3b\u5728\u53d1\u8fbe\u56fd\u5bb6\u7684\u4eba\u4eec\u4e0d\u518d\u53d7\u5230\u5bc4\u751f\u866b\u7684\u5a01\u80c1\u3002\u5728\u8fd9\u4e9b\u4eba\u7fa4\u4e2d\uff0c\u80a5\u5927\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u4f1a\u56e0\u4e00\u4e9b\u65e0\u5bb3\u7684\u6297\u539f(\u5982\u82b1\u7c89)\u4ea7\u751f\u2160\u578b\u8d85\u654f\u53cd\u5e94\uff08\u7b2c27\u7ae0<\/span>\uff09\u3002\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u548c\u80a5\u5927\u7ec6\u80de\u5206\u6ccc\u591a\u79cd\u4ecb\u8d28\uff0c\u5176\u4e2d\u8bb8\u591a\u662f\u53d8\u6001\u53cd\u5e94\u6cbb\u7597\u7684\u9776\u6807\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de\u5177\u6709\u4e24\u4e2a\u91cd\u8981\u4f5c\u7528\u3002\u5b83\u4eec\u662f\u6740\u6b7b\u67d0\u4e9b\u88ab\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u7684\u7edd\u4f73\u6740\u624b\uff0c\u4f46\u50cf\u5de8\u566c\u7ec6\u80de\u4e00\u6837\uff0c\u5b83\u4eec\u8fd8\u5177\u6709\u523a\u6fc0\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u4f5c\u7528\u3002\u5728\u8fd9\u91cc\uff0c\u201c\u81ea\u7136\u201d\u4e00\u8bcd\u662f\u6307\u8fd9\u4e9b\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u9776\u6807\u5e76\u4e0e\u9776\u6807\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u65e0\u9700\u4efb\u4f55\u6fc0\u6d3b\u6216\u5148\u524d\u7684\u654f\u5316\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u4e00\u90e8\u5206\uff0c\u540c\u65f6\u4e5f\u586b\u8865\u4e86\u7279\u5b9a\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u6f5c\u5728\u7a7a\u767d\u3002\u5f53\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u8bc6\u522b\u4e0e\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09\u7ed3\u5408\u7684\u75c5\u6bd2\u80bd\u65f6\uff0c\u5927\u591a\u6570\u611f\u67d3\u75c5\u6bd2(\u5982\u6d41\u611f)\u7684\u7ec6\u80de\u5728\u7ec6\u80de\u6bd2\u4f5c\u7528\u4e0b\u88ab\u6740\u6b7b\u3002\u4e00\u4e9b\u611f\u67d3\u6027\u56e0\u5b50\uff0c\u7279\u522b\u662f\u75b1\u75b9\u75c5\u6bd2\u5bb6\u65cf\u6210\u5458\uff0c\u53ef\u4e0b\u8c03\u611f\u67d3\u7ec6\u80de\u4e0a\u7684MHC\u8868\u8fbe\uff0c\u4ece\u800c\u9003\u907fT\u7ec6\u80de\u7684\u68c0\u6d4b\u3002\u75b1\u75b9\u75c5\u6bd2\u8fd8\u53ef\u4ee5\u963b\u65ad\u7ec6\u80de\u5185\u7684\u6297\u539f\u63d0\u5448\u9014\u5f84\uff08\u7b2c10\u7ae0<\/span>\uff09\u3002\u8fd9\u4e9b\u9003\u9038\u673a\u5236\u963b\u6b62\u4e86CTL\u7684\u8bc6\u522b\uff0c\u4f46\u662fNK\u7ec6\u80de\u4ecd\u7136\u80fd\u591f\u8bc6\u522b\u5e76\u6740\u6b7b\u611f\u67d3\u75b1\u75b9\u75c5\u6bd2\u7684\u7ec6\u80de\uff0c\u56e0\u4e3a\u5b83\u4eec\u5df2\u7ecf\u8fdb\u5316\u6210\u80fd\u591f\u8bc6\u522b\u5e76\u6740\u6b7bMHC\u8868\u8fbe\u4f4e\u7684\u7ec6\u80de\uff08Fig22.6<\/span>\uff09\u3002\u7c7b\u4f3c\u5730\uff0c\u4e00\u4e9b\u80bf\u7624\u7ec6\u80de\u83b7\u5f97\u4e86MHC\u8868\u8fbe\u964d\u4f4e\u7684\u7a81\u53d8\uff0c\u5b83\u4eec\u80fd\u591f\u9003\u907f\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u6740\u4f24\uff0c\u4f46\u4e0d\u80fd\u9003\u907fNK\u7ec6\u80de\u7684\u6740\u4f24\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.6 <\/span>\u6d41\u611f\u75c5\u6bd2\u548c\u5355\u7eaf\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\u7ec6\u80de\u6740\u706d\u4f5c\u7528\u7684\u6bd4\u8f83<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de\u5728\u9aa8\u9ad3\u4e2d\u53d1\u80b2\u5e76\u83b7\u5f97\u53d7\u4f53\u3002\u5c3d\u7ba1\u5b83\u4eec\u4e0d\u662f\u5728\u80f8\u817a\u4e2d\u4ea7\u751f\u7684\uff0c\u4f46\u5b83\u4eec\u4e0eT\u7ec6\u80de\u5177\u6709\u67d0\u4e9b\u5171\u540c\u7279\u5f81\u3002\u4f8b\u5982\u5b83\u4eec\u4e0eT\u7ec6\u80de\u6709\u4e00\u4e9b\u76f8\u540c\u7684\u8868\u9762\u5206\u5b50\uff0c\u5982CD2\uff1b\u5e76\u4e14\u5177\u6709\u4e0e\u6dcb\u5df4\u7ec6\u80de\u76f8\u4f3c\u7684\u5916\u89c2\uff0c\u56e0\u6b64NK\u7ec6\u80de\u7684\u53e6\u4e00\u4e2a\u540d\u79f0\u662f\u5927\u9897\u7c92\u6dcb\u5df4\u7ec6\u80de\uff08Fig22.7<\/span>\uff09\u3002NK\u7ec6\u80de\u4e5f\u4f7f\u7528\u4e0eCTL\u76f8\u540c\u7684\u901a\u7528\u6740\u4f24\u673a\u5236\u3002\u4f46\u662f\uff0c\u5b83\u4eec\u6ca1\u6709\u91cd\u6392\u7684T\u7ec6\u80de\u53d7\u4f53\u5206\u5b50\uff0c\u56e0\u6b64\u88ab\u5f52\u4e3a\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u3002NK\u7ec6\u80de\u8fd8\u5177\u6709\u5de8\u566c\u7ec6\u80de\u7684\u67d0\u4e9b\u7279\u5f81\uff1a\u6bd4\u5982\u80fd\u591f\u8bc6\u522b\u6297\u4f53\u5305\u88ab\u7684\u9776\u7ec6\u80de\uff0c\u4f46\u4e0d\u80fd\u901a\u8fc7\u541e\u566c\u4f5c\u7528\u6740\u6b7b\u5b83\u4eec\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.7<\/span> \u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4e2d\u7684\u9897\u7c92\u542b\u6709\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1\u5c1a\u4e0d\u6e05\u695aNK\u7ec6\u80de\u7684\u4ea7\u751f\u662f\u5982\u4f55\u53d7\u5230\u8c03\u8282\u7684\uff0c\u4f46\u53ef\u4ee5\u786e\u5b9a\u7684\u662fNK\u7ec6\u80de\u4e0eT\u548cB\u7ec6\u80de\u90fd\u662f\u8d77\u6e90\u4e8e\u6dcb\u5df4\u6837\u7956\u7ec6\u80de\u3002NK\u7ec6\u80de\u7ea6\u5360\u5916\u5468\u8840\u6dcb\u5df4\u7ec6\u80de\u76845\uff05\u81f315\uff05\u3002\u5b83\u4eec\u88ab\u7ec6\u80de\u56e0\u5b50\u6fc0\u6d3b\uff08Fig2.8<\/span>\uff09\uff0c\u4f46\u662f\u5176\u6740\u4f24\u529b\u662f\u901a\u8fc7\u7279\u6b8a\u53d7\u4f53\u7684\u4fe1\u53f7\u4f20\u5bfc\u6765\u8c03\u8282\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.8<\/span> \u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de\u7684\u7ec6\u80de\u56e0\u5b50\u8c03\u63a7<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u81ea\u7136\u6740\u4f24\u53d7\u4f53<\/strong><\/p>\n<\/section>\n

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\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u8868\u8fbe20\u591a\u79cd\u4e0d\u540c\u7684\u53d7\u4f53\uff0c\u5b83\u4eec\u5c5e\u4e8e\u4e24\u4e2a\u4e0d\u540c\u7684\u5bb6\u65cf\uff0c\u5373\u6291\u5236\u6027\u53d7\u4f53\u548c\u6fc0\u6d3b\u6027\u53d7\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u6291\u5236\u6027\u53d7\u4f53<\/strong><\/p>\n<\/section>\n

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\u6740\u4f24\u6027\u514d\u75ab\u7403\u86cb\u767d\u6837\u53d7\u4f53\uff08KIR\uff09\u662f\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u7684\u6210\u5458\uff0c\u53ef\u8bc6\u522b\u7279\u5b9a\u7684MHC\u03b1\u94fe\u3002NKG2\u548cCD94\u662f\u8bc6\u522b\u975e\u7ecf\u5178\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539fE\uff08HLA-E\uff09\u5206\u5b50\u7684C-\u51dd\u96c6\u7d20\u5206\u5b50\u3002\u4e24\u79cd\u7c7b\u578b\u7684\u53d7\u4f53\u90fd\u662f\u7279\u6b8a\u7684\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u6291\u5236\u6740\u4f24\u3002\u8be5\u4e3b\u5bfc\u4fe1\u53f7\u4f18\u5148\u4e8e\u6240\u6709\u5176\u4ed6\u4fe1\u53f7\uff1a\u5373\u5982\u679cNK\u7ec6\u80de\u68c0\u6d4b\u5230MHC\u5c31\u4e0d\u4f1a\u8fdb\u884c\u6740\u4f24\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u6fc0\u6d3b\u6027\u53d7\u4f53<\/strong><\/p>\n<\/section>\n

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NK\u7ec6\u80de\u4e5f\u8868\u8fbe\u4e00\u4e9b\u6fc0\u6d3b\u6027\u53d7\u4f53\u3002\u5728NK\u7ec6\u80de\u4e2d\uff0c\u4e00\u79cd\u7279\u6b8a\u7684Fc\u53d7\u4f53\uff0cFc\u03b3RIII\uff0c\u53ef\u8bc6\u522b\u611f\u67d3\u7ec6\u80de\u8868\u9762\u7684\u4e0eIg G\u7ed3\u5408\u7684\u75c5\u6bd2\u6297\u539f\uff0c\u5e76\u89e6\u53d1\u6740\u4f24\u3002IgG\u4ecb\u5bfc\u7684NK\u6740\u4f24\u88ab\u79f0\u4e3a\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528(ADCC)\uff0c\u5982Fig22.9<\/span>\u6240\u793a\u3002\u4e00\u4e9b\u5de8\u566c\u7ec6\u80de\u4e5f\u8868\u8fbeFc\u03b3RIII\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u514d\u75ab\u7403\u86cb\u767dIgG\u8d77\u8c03\u7406\u4f5c\u7528\uff0c\u89e6\u53d1\u541e\u566c\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.9<\/span> \u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528(ADCC)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f53NK\u7ec6\u80de\u9047\u5230\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u65f6\uff0c\u6709\u4e24\u79cd\u53ef\u80fd\u7684\u7ed3\u679c(Fig22.10<\/span>)\uff1a<\/p>\n

1.NK\u7ec6\u80de\u5229\u7528\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u6a21\u5f0f\u8bc6\u522b\u5206\u5b50\u8bc6\u522b\u7ec6\u80de\u662f\u5426\u88ab\u611f\u67d3\u3002NK\u7ec6\u80de\u5229\u7528\u5176\u53d7\u4f53\u68c0\u67e5\u7ec6\u80de\u8868\u9762\u662f\u5426\u5b58\u5728MHC\u3002\u5982\u679cMHC\u5904\u4e8e\u8db3\u591f\u7684\u6c34\u5e73\uff0c\u53d7\u4f53\u5c31\u4f1a\u53d1\u51fa\u8d1f\u4fe1\u53f7\uff0c\u963b\u6b62NK\u7ec6\u80de\u7684\u6740\u4f24\u3002\u56e0\u4e3a\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u8868\u8fbeMHC\uff0c\u4e0d\u7ba1\u600e\u6837\u5b83\u90fd\u4f1a\u88abCTL\u6740\u6b7b\u3002<\/p>\n

2.\u5982\u679cNK\u8bc6\u522b\u5230\u4e00\u4e2a\u7ec6\u80de\u88ab\u75c5\u6bd2\u611f\u67d3\uff0c\u5e76\u786e\u8ba4MHC\u6c34\u5e73\u964d\u4f4e\uff0c\u5b83\u5c31\u4f1a\u7ee7\u7eed\u6740\u6b7b\u76ee\u6807\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.10 <\/span>\u5de6\u8fb9\u7684\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de\u4e0d\u4f1a\u6740\u6b7b\u88ab\u611f\u67d3\u7684\u7ec6\u80de\uff0c\u56e0\u4e3a\u5b83\u4ecd\u7136\u8868\u8fbe\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\uff0c\u53f3\u8fb9\u88ab\u611f\u67d3\u7684\u7ec6\u80de\u5df2\u7ecf\u505c\u6b62\u8868\u8fbeMHC\uff0c\u5c06\u4f1a\u88ab\u6740\u6b7b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u523a\u6fc0\u4fe1\u53f7\u548c\u6291\u5236\u4fe1\u53f7\u4e4b\u95f4\u7684\u5e73\u8861\u51b3\u5b9a\u4e86NK\u7ec6\u80de\u6d3b\u5316\u7684\u7ed3\u679c\uff0cNK\u4f18\u5148\u6740\u4f24\u4e0d\u8868\u8fbeMHC\u7684\u7ec6\u80de\u3002\u7ec6\u80de\u53ef\u80fd\u56e0\u4e3a\u75c5\u6bd2\u611f\u67d3\u6216\u764c\u7ec6\u80de\u7a81\u53d8\u800c\u7f3a\u4e4fMHC\u7684\u8868\u8fbe\uff0c\u8fd9\u4e24\u4e2a\u8fc7\u7a0b\u90fd\u80fd\u4f7f\u5f02\u5e38\u7ec6\u80de\u9003\u8131CTL\u7684\u6740\u4f24\u3002NK\u7ec6\u80de\u901a\u8fc7\u6740\u6b7b\u7f3a\u4e4fMHC\u8868\u8fbe\u7684\u7ec6\u80de\u6765\u514b\u670d\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u8fd9\u4e00\u6f5c\u5728\u7f3a\u9677\u3002\u5f53\u5e72\u6270\u7d20\u03b3(IFN-\u03b3)\u5b58\u5728\u65f6\uff0c\u8fd9\u79cd\u7c7b\u578b\u7684\u6740\u4f24\u5c24\u5176\u91cd\u8981\uff1b\u7ec6\u80de\u56e0\u5b50\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u4e86\u6b63\u5e38\u7ec6\u80de\u7684MHC\u8868\u8fbe\uff0c\u540c\u65f6\u4e5f\u589e\u5f3a\u4e86NK\u7ec6\u80de\u7684\u6d3b\u6027\u3002MHC\u8868\u8fbe\u51cf\u5c11\u8d77\u5371\u9669\u4fe1\u53f7\u7684\u4f5c\u7528\uff0c\u63d0\u9192NK\u7ec6\u80de\u6ce8\u610f\u611f\u67d3\u7684\u5b58\u5728\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de\u5728\u80ce\u76d8\u4e2d\u626e\u6f14\u7740\u66f4\u91cd\u8981\u7684\u89d2\u8272\uff0c\u5728\u80ce\u76d8\u4e2d\uff0c\u7236\u4eb2\u548c\u6bcd\u4eb2\u7684MHC\u57fa\u56e0\u90fd\u53ef\u80fd\u8868\u8fbe\u3002NK\u7ec6\u80de\u662f\u598a\u5a20\u5b50\u5bab\u4e2d\u514d\u75ab\u7cfb\u7edf\u7684\u4e3b\u8981\u7ec6\u80de\u3002\u5b50\u5babNK\u7ec6\u80de\u5728\u598a\u5a20\u671f\u95f4\u5177\u6709\u9884\u9632\u5b50\u5bab\u548c\u80ce\u513f\u75c5\u6bd2\u611f\u67d3\u7684\u4f5c\u7528\u3002\u5b83\u4eec\u8fd8\u6709\u4e00\u4e2a\u989d\u5916\u7684\u4f18\u52bf\uff0c\u5373\u4f7f\u80ce\u513f\u7ec4\u7ec7\u8868\u8fbe\u5916\u6e90(\u7236\u4eb2\u7684)HLA\u5206\u5b50\uff0c\u4e5f\u4e0d\u4f1a\u653b\u51fb\u5b83\u3002\u8fd9\u662f\u56e0\u4e3aNK\u7ec6\u80de\u53d7\u5230MHC\u7684\u6291\u5236\uff0c\u4e0d\u7ba1\u5b83\u6765\u81ea\u6bcd\u7cfb\u8fd8\u662f\u7236\u7cfb\u3002CTL\u4e5f\u80fd\u591f\u6740\u6b7b\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\uff0c\u4f46\u524d\u63d0\u662f\u6bcd\u4f53MHC\u4e0a\u6709\u6297\u539f\u3002\u76f8\u53cd\uff0cCTL\u4f1a\u5728\u540c\u79cd\u5f02\u4f53\u53cd\u5e94\u4e2d\u653b\u51fb\u8868\u8fbe\u7236\u7cfbMHC\u7684\u80ce\u76d8\u7ec6\u80de\uff0c\u7c7b\u4f3c\u4e8e\u79fb\u690d\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CTL\u4e0e\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u6548\u5e94\u673a\u5236<\/strong><\/p>\n<\/section>\n

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NK\u7ec6\u80de\u4f7f\u7528\u7684\u7ec6\u80de\u6bd2\u673a\u5236\u4e0eCTL\u4f7f\u7528\u7684\u76f8\u540c\u3002\u8fd9\u4e24\u79cd\u7ec6\u80de\u90fd\u901a\u8fc7\u7a7f\u5b54\u7d20\/\u9897\u7c92\u9176\u3001Fas\u914d\u4f53(FasL)\u3001\u6216\u5206\u6cccTNF\u8bf1\u5bfc\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1(\u51cb\u4ea1)\u3002NK\u7ec6\u80de\u548cCTL\u8fd8\u53ef\u5206\u6ccc\u514d\u75ab\u8c03\u8282\u7ec6\u80de\u56e0\u5b50\uff0c\u5982\u5e72\u6270\u7d20-\u03b3\uff0c\u5b83\u80fd\u4fc3\u8fdbTh1\u708e\u75c7\u53cd\u5e94\uff0c\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7a7f\u5b54\u86cb\u767d\uff08\u7a7f\u5b54\u7d20\uff09<\/strong><\/p>\n<\/section>\n

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\u7a7f\u5b54\u7d20\u5b58\u5728\u4e8eNK\u7ec6\u80de\u548cCTL\u7684\u7ec6\u80de\u6bd2\u9897\u7c92\u4e2d\u3002\u5f53CTL\u6216NK\u7ec6\u80de\u88ab\u6fc0\u6d3b\u65f6\uff0c\u808c\u52a8\u86cb\u767d\u7ec6\u80de\u9aa8\u67b6\u88ab\u91cd\u7ec4\uff0c\u56e0\u6b64\u7a7f\u5b54\u7d20\u5206\u5b50\u88ab\u79fb\u52a8\u5230\u7ec6\u80de\u8868\u9762\u3002\u7a7f\u5b54\u7d20\u805a\u5408\u5e76\u5f62\u6210\u4e00\u4e2a\u5b54\uff0c\u63d2\u5165\u5230\u9776\u7ec6\u80de\u819c\u4e2d\uff0c\u5f88\u50cf\u8865\u4f53\u819c\u653b\u51fb\u590d\u5408\u4f53(MAC\uff1b\u89c1Fig22.9<\/span>)\u3002\u8fd9\u4e9b\u5b54\u9699\u5141\u8bb8\u76d0\u548c\u6c34\u6d41\u5165\u76ee\u6807\u7ec6\u80de\uff1b\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u4eec\u4f7f\u9897\u7c92\u9176\u80fd\u591f\u8fdb\u5165\u7ec6\u80de\u8d28\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9897\u7c92\u9176<\/strong><\/p>\n<\/section>\n

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\u9897\u7c92\u9176\u7531\u4e09\u79cd\u4e0d\u540c\u7684\u86cb\u767d\u6c34\u89e3\u9176\u7ec4\u6210\uff0c\u901a\u8fc7\u6fc0\u6d3b\u7684\u7ec6\u80de\u9aa8\u67b6\u8fd0\u8f93\u8f6c\u79fb\u81f3\u9776\u7ec6\u80de\u3002\u9664\u4e86\u964d\u89e3\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u5916\uff0c\u5b83\u4eec\u8fd8\u80fd\u7279\u5f02\u6027\u5730\u6fc0\u6d3bcaspase\u9176\u7cfb\u7edf\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fas\u914d\u4f53<\/strong><\/p>\n<\/section>\n

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Fas\u914d\u4f53(FasL)\u662f\u4e00\u79cd\u5f3a\u6709\u529b\u7684\u7ec6\u80de\u51cb\u4ea1\u8bf1\u5bfc\u5242\uff0cNK\u7ec6\u80de\u548cCTL\u901a\u8fc7\u5b83\u6765\u6740\u4f24\u611f\u67d3\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u3002Fas\u4e0eTNF\u53d7\u4f53\u5c5e\u4e8e\u540c\u4e00\u53d7\u4f53\u5bb6\u65cf(Fig22.11<\/span>)\uff0cFas\u548cFasL\u5728\u6fc0\u6d3b\u8fc7\u7a0b\u4e2d\u5728\u514d\u75ab\u7cfb\u7edf\u7684\u7ec6\u80de\u4e0a\u8868\u8fbe\u3002\u5f53CTL\u548cNK\u7ec6\u80de\u88ab\u6fc0\u6d3b\u65f6\uff0cFasL\u7684\u8868\u8fbe\u589e\u52a0\uff1bFasL\u4e0e\u9776\u7ec6\u80de\u4e0a\u7684Fas\u7ed3\u5408\uff0c\u7136\u540e\u901a\u8fc7\u540e\u9762\u63cf\u8ff0\u7684\u673a\u5236\u53d1\u751f\u51cb\u4ea1\u3002T\u7ec6\u80de\u4e5f\u53ef\u80fd\u8868\u8fbeFas\uff0c\u5e76\u53ef\u6210\u4e3aFas\u4ecb\u5bfc\u7684\u6740\u4f24\u9776\u70b9\u3002\u4f8b\u5982\uff0c\u514d\u75ab\u7279\u6b8a\u90e8\u4f4d(\u5982\u777e\u4e38)\u7684\u7ec6\u80de\u8868\u8fbeFasL\u3002\u4efb\u4f55\u610f\u5916\u8fdb\u5165\u777e\u4e38\u7684T\u7ec6\u80de\u90fd\u4f1a\u66b4\u9732\u5728Fas\u4e2d\u5e76\u53d1\u751f\u51cb\u4ea1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig22.11 <\/span>Fas\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u53d7\u4f53\u5747\u53ef\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de\u4e0d\u4ec5\u5177\u6709\u5f88\u5f3a\u7684\u6740\u4f24\u80fd\u529b\uff0c\u800c\u4e14\u5b83\u4eec\u4e5f\u80fd\u901a\u8fc7\u5206\u6ccc\u523a\u6fc0TH1\u53cd\u5e94\u7684\u7ec6\u80de\u56e0\u5b50\u6765\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u3002\u5de8\u566c\u7ec6\u80de\u540c\u6837\u5982\u6b64\uff0c\u8fd9\u6b63\u662f\u6211\u4eec\u5bf9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u7684\u671f\u671b\u3002\u8fd9\u4e24\u79cd\u7c7b\u578b\u7684\u7ec6\u80de\u90fd\u8bc6\u522b\u75c5\u539f\u4f53\u5bb6\u65cf\uff0c\u800c\u4e0d\u662f\u7279\u5b9a\u7684\u6297\u539f\uff0c\u4ed6\u4eec\u8bd5\u56fe\u6839\u9664\u75c5\u539f\u4f53\uff0c\u4f46\u4e5f\u4f1a\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f53NK\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u76f8\u9047\u65f6\uff0c\u5b83\u4eec\u4f1a\u5206\u6ccc\u5e72\u6270\u7d20-\u03b3\u3002\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u523a\u6fc0TH1\u7ec6\u80de\uff0c\u6291\u5236TH2\u7ec6\u80de\u3002TH1\u53cd\u5e94\u5728\u5904\u7406\u7ec6\u80de\u5185\u611f\u67d3\u65b9\u9762\u7279\u522b\u6709\u6548\uff0c\u53ef\u4ee5\u5f62\u6210\u514d\u75ab\u8bb0\u5fc6\uff0c\u4ee5\u4fdd\u8bc1\u5bbf\u4e3b\u518d\u6b21\u66b4\u9732\u4e8e\u76f8\u540c\u75c5\u539f\u4f53\u65f6\u4ea7\u751f\u5f3a\u70c8\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u51cb\u4ea1\u7684\u7ec6\u80de\u5185\u673a\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7ae0\u4e3b\u8981\u5173\u6ce8\u901a\u8fc7\u8fde\u63a5Fas\u6216TNF\u53d7\u4f53\u7b49\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1(\u89c1Fig22.11<\/span>)\u3002\u7136\u800c\uff0c\u65e0\u8bba\u6709\u591a\u5c11\u4e0d\u540c\u7684\u89e6\u53d1\u56e0\u7d20\uff0c\u7ec6\u80de\u51cb\u4ea1\u7684\u7ec6\u80de\u5185\u673a\u5236\u662f\u76f8\u4f3c\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fas\u548cTNF\u53d7\u4f53\u90fd\u6709\u7ec6\u80de\u8d28\u5c3e\u5df4\uff0c\u79f0\u4e3a\u6b7b\u4ea1\u7ed3\u6784\u57df\uff0c\u53ef\u4ee5\u6fc0\u6d3bcaspase\u7cfb\u5217\u9176(Fig22.12<\/span>)\u3002\u534a\u80f1\u6c28\u9178\u5929\u51ac\u6c28\u9178\u86cb\u767d\u9176(Caspases)\u662f\u4e00\u7c7b\u86cb\u767d\u6c34\u89e3\u9176\uff0c\u5b83\u80fd\u5728\u5929\u51ac\u6c28\u9178\u6b8b\u57fa\u540e\u88c2\u89e3\u86cb\u767d\u3002\u6fc0\u6d3bcaspase\u7684\u6700\u7ec8\u7ed3\u679c\u662f\u6fc0\u6d3b\u4e00\u79cd\u7279\u5b9a\u7684DNA\u9176\uff0c\u5b83\u5c06\u9776\u7ec6\u80de\u7684DNA\u88c2\u89e3\u6210200\u4e2a\u78b1\u57fa\u5bf9\u957f\u5ea6\u7684\u7247\u6bb5\u3002\u5f53NK\u6216CTL\u5c06\u9897\u7c92\u9176\u6ce8\u5165\u7ec6\u80de\u5185\u65f6\uff0ccaspase\u9176\u4e5f\u88ab\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig22.12<\/span> \u8fd9\u79cdB\u7ec6\u80de\u662f\u5426\u53d1\u751f\u51cb\u4ea1\u53d6\u51b3\u4e8eFas\u3001caspases\u3001\u767d\u7ec6\u80de\u4ecb\u7d202(IL-2)\u548cBcl-2\u4fe1\u53f7\u4e4b\u95f4\u7684\u5e73\u8861<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u4e2a\u7ec6\u80de\u51cb\u4ea1\u7684\u65e9\u671f\u5f71\u54cd\u662f\u7ebf\u7c92\u4f53\u7684\u635f\u4f24\uff0c\u8fd9\u4f1a\u5bfc\u81f4\u7ebf\u7c92\u4f53\u5185\u5bb9\u7269\u7684\u91ca\u653e\uff1b\u968f\u540e\u8fdb\u4e00\u6b65\u6fc0\u6d3b\u534a\u80f1\u6c28\u9178\u5929\u51ac\u6c28\u9178\u86cb\u767d\u9176\u3002Bcl-2\u662f\u4e00\u79cd\u6297\u51cb\u4ea1\u86cb\u767d\uff0c\u5b83\u7ed3\u5408\u5e76\u7a33\u5b9a\u7ebf\u7c92\u4f53\uff0c\u9632\u6b62\u51cb\u4ea1\u4e0a\u8c03(\u7b2c17\u7ae0<\/span>)\u3002IL-2\u6c34\u5e73\u4e0b\u964d\u4f1a\u964d\u4f4eBcl-2\u5728\u7ec6\u80de\u5185\u7684\u6d53\u5ea6\uff0c\u4f7f\u7ec6\u80de\u66f4\u5bb9\u6613\u53d1\u751f\u51cb\u4ea1\u3002\u8fd9\u53d1\u751f\u5728\u514d\u75ab\u5e94\u7b54\u6210\u529f\u6e05\u9664\u6297\u539f\u65f6\uff0c\u6297\u539f\u6c34\u5e73\u4e0b\u964d\uff0cIL-2\u5206\u6ccc\u51cf\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u51cb\u4ea1<\/strong><\/p>\n<\/section>\n

\n
\n
\n

\u7ec6\u80de\u51cb\u4ea1\u662f\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u7684\u8fc7\u7a0b\uff0c\u8fd9\u662f\u4e00\u79cd\u751f\u7406\u6027\u6b7b\u4ea1\u3002\u51cb\u4ea1\u7ec6\u80de\u53ef\u88ab\u541e\u566c\u7ec6\u80de\u8bc6\u522b\uff0c\u541e\u566c\u7ec6\u80de\u901a\u5e38\u5728\u4e0d\u6fc0\u53d1\u708e\u75c7\u7684\u60c5\u51b5\u4e0b\u6e05\u9664\u7ec6\u80de\u6b8b\u7559\u7269\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u574f\u6b7b\u662f\u7ec6\u80de\u7684\u610f\u5916\u6b7b\u4ea1\uff0c\u901a\u5e38\u662f\u7531\u4e8e\u65b0\u9648\u4ee3\u8c22\u51fa\u73b0\u95ee\u9898\uff0c\u5982\u7f3a\u6c27\u6216\u6bd2\u7d20\u5f15\u8d77\u3002\u574f\u6b7b\u4e0d\u4f1a\u5bfc\u81f4DNA\u7247\u6bb5\u5316\uff0c\u56e0\u4e3a\u5b83\u6fc0\u6d3b\u8865\u4f53\u7ea7\u8054\u53cd\u5e94\uff0c\u6240\u4ee5\u901a\u5e38\u4f1a\u5bfc\u81f4\u708e\u75c7\u53cd\u5e94(Table22.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 22.3 <\/span>\u7ec6\u80de\u51cb\u4ea1\u4e0e\u574f\u6b7b\u7684\u6bd4\u8f83<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u51cb\u4ea1\u662f\u5f71\u54cd\u8bb8\u591a\u673a\u4f53\u7cfb\u7edf\u7684\u91cd\u8981\u751f\u7406\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0c\u5728\u80da\u80ce\u53d1\u80b2\u671f\u95f4\uff0c\u7ec6\u80de\u51cb\u4ea1\u53c2\u4e0e\u7ec4\u7ec7\u91cd\u5851\uff0c\u5982\u53d1\u80b2\u4e2d\u7684\u8840\u7ba1\u7cfb\u7edf\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u5f0f\uff0c\u7ec6\u80de\u51cb\u4ea1\u51b3\u5b9a\u4e86\u53d1\u80b2\u4e2d\u7684\u80ce\u513f\u7684\u5f62\u72b6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u51cb\u4ea1\u5728\u5f62\u6210\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u4e2d\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\u3002\u81ea\u8eab\u53cd\u5e94\u6027T\u548cB\u7ec6\u80de\u5728\u80f8\u817a\u548c\u9aa8\u9ad3\u4e2d\u751f\u6210\u540e\u4e0d\u4e45\u5c31\u4f1a\u53d1\u751f\u51cb\u4ea1(\u9632\u6b62\u81ea\u8eab\u514d\u75ab\u75c5\u7684\u53d1\u751f)\u3002\u6b64\u5916\uff0c\u5728\u5bf9\u75c5\u539f\u4f53\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\u540e\uff0c\u591a\u4f59\u7684\u6dcb\u5df4\u7ec6\u80de\u4e5f\u4f1a\u901a\u8fc7\u51cb\u4ea1\u88ab\u6e05\u9664\u3002\u5176\u4e2d\u6bcf\u4e00\u79cd\u90fd\u4f7f\u7528\u4e0d\u540c\u7684\u51cb\u4ea1\u89e6\u53d1\u673a\u5236\uff0c\u4f46\u7ed3\u679c\u662f\u5f62\u6210\u4e86\u514d\u75ab\u53cd\u5e94\u7684\u7279\u5f02\u6027(Table22.4<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Table22.4<\/span> \u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u51cb\u4ea1<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u7ec6\u80de\u51cb\u4ea1\u4e5f\u53c2\u4e0e\u4e86\u4e00\u4e9b\u75c5\u7406\u8fc7\u7a0b\uff0c\u4f8b\u5982\uff0c\u6709\u8bc1\u636e\u8868\u660e\uff0cHIV\u611f\u67d3\u7834\u574fCD4+<\/sup>T\u7ec6\u80de\u7684\u65b9\u5f0f\u4e4b\u4e00\u662f\u901a\u8fc7\u8bf1\u5bfc\u51cb\u4ea1\u3002\u5f53\u51cb\u4ea1\u788e\u7247\u6ca1\u6709\u88ab\u541e\u566c\u7ec6\u80de\u5145\u5206\u6e05\u9664\u65f6\uff0c\u5b83\u53ef\u4ee5\u5177\u6709\u514d\u75ab\u539f\u6027\uff0c\u8fd9\u4f1a\u5bfc\u81f4\u81ea\u8eab\u6297\u4f53\u7684\u4ea7\u751f\uff0c\u4f8b\u5982\u9488\u5bf9DNA\u7684\u6297\u4f53\uff0c\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5982\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae(SLE)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u51cb\u4ea1\u7f3a\u9677\u53ef\u80fd\u53d1\u751f\u5728\u7a81\u53d8\u6216\u67d3\u8272\u4f53\u6613\u4f4d\u5bfc\u81f4Bcl-2\u6c34\u5e73\u5347\u9ad8\u7684B\u7ec6\u80de\u514b\u9686\u4e2d\uff0c\u8fd9\u4e9b\u7a81\u53d8\u6216\u67d3\u8272\u4f53\u6613\u4f4d\u7684\u7ec6\u80de\u53ef\u80fd\u4f1a\u53d7\u5230\u4fdd\u62a4\u800c\u514d\u4e8e\u51cb\u4ea1\uff0c\u5e76\u53d1\u5c55\u4e3a\u6076\u6027B\u7ec6\u80de\u80bf\u7624(\u7b2c35\u7ae0<\/span>)\u3002\u67d0\u4e9b\u75b1\u75b9\u75c5\u6bd2\u611f\u67d3\u4e5f\u53ef\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u7f3a\u9677\u3002\u4f8b\u5982\uff0c\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd24\u578b(EBV)\u901a\u8fc7\u4ea7\u751f\u4e00\u79cd\u7c7b\u4f3cBcl-2\u7684\u86cb\u767d\u6765\u9003\u907f\u7ec6\u80de\u51cb\u4ea1\u3002\u8fd9\u4f1a\u4f7f\u88ab\u8be5\u79cd\u75c5\u6bd2\u611f\u67d3\u7684B\u7ec6\u80de\u201c\u6c38\u751f\u201d\uff0c\u4e5f\u53ef\u80fd\u5bfc\u81f4B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u7684\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Box22.1 <\/span>\u9acb\u5173<\/span>\u8282\u7f6e\u6362\u672f\u4e2d\u5b58\u5728\u7684\u4e25\u91cd\u95ee\u9898<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

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<\/svg><\/section>\n<\/section>\n
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<\/svg><\/section>\n<\/section>\n<\/section>\n
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67\u5c81\u5973\u6027\u60a3\u8005\u8ba1\u5212\u63a5\u53d7\u9acb\u5173\u8282\u7f6e\u6362\u624b\u672f\uff0c\u5168\u9ebb\u540e\u5f00\u59cb\u624b\u672f\u3002\u76ae\u80a4\u5207\u5f00\u540e4min\uff0c\u9759\u8109\u6ce8\u5c04\u6297\u751f\u7d20\u5934\u5b62\u544b\u8f9b\u4ee5\u964d\u4f4e\u672f\u540e\u611f\u67d3\u7684\u98ce\u9669\u3002\u5927\u7ea61\u5206\u949f\u540e\uff0c\u9ebb\u9189\u5e08\u6ce8\u610f\u5230\u5979\u7684\u8840\u538b\u4ece150\/87 mm Hg\u5927\u5e45\u4e0b\u964d\u523065\/35 mm Hg\u3002\u8d77\u521d\uff0c\u9ebb\u9189\u5e08\u6000\u7591\u8840\u538b\u4e0b\u964d\u662f\u7531\u4e8e\u624b\u672f\u90e8\u4f4d\u51fa\u8840\uff0c\u4f46\u5916\u79d1\u533b\u751f\u8bf4\u8fd9\u4e0d\u592a\u53ef\u80fd\u3002\u51e0\u79d2\u949f\u540e\uff0c\u75c5\u4eba\u7684\u547c\u5438\u53d8\u5f97\u975e\u5e38\u56f0\u96be\uff0c\u4ed6\u7684\u8840\u6c27\u9971\u548c\u5ea6\u5df2\u7ecf\u4ece97%\u964d\u5230\u4e8663%\u3002\u9ebb\u9189\u5e08\u6000\u7591\u8fd9\u662f\u5934\u5b62\u544b\u8f9b\u7684\u8fc7\u654f\u53cd\u5e94(\u4e25\u91cd\u8fc7\u654f)\uff0c\u4e8e\u662f\u7ed9\u4ed6\u6ce8\u5c04\u4e86\u80be\u4e0a\u817a\u7d20\u3002\u4f46\u75c5\u4eba\u5bf9\u80be\u4e0a\u817a\u7d20\u7684\u53cd\u5e94\u8f83\u5f31\uff0c\u6700\u7ec8\u9ebb\u9189\u5e08\u5728\u8840\u538b\u548c\u901a\u6c14\u969c\u788d\u6062\u590d\u4e4b\u524d\u6ce8\u5c04\u4e09\u5242\u80be\u4e0a\u817a\u7d20\u3002\u624b\u672f\u653e\u5f03\u30021\u5c0f\u65f6\u548c24\u5c0f\u65f6\u540e\u5206\u522b\u62bd\u53d6\u8840\u6837\u68c0\u6d4b\u80a5\u5927\u7ec6\u80de\u7c7b\u80f0\u86cb\u767d\u9176(MCT)\u3002<\/p>\n

\u75c5\u4eba\u5728\u51e0\u5468\u540e\u63a5\u53d7\u8fc7\u654f\u4e13\u79d1\u533b\u751f\u7684\u68c0\u67e5\u65f6\uff0c\u80a5\u5927\u7ec6\u80de\u7c7b\u80f0\u86cb\u767d\u9176\u7684\u7ed3\u679cMCT\u6c34\u5e73\u4e3a245\u00b5g\/L\uff0c\u6b21\u65e5MCT\u6c34\u5e73\u5df2\u964d\u81f38.5\u00b5g\/L\u3002MCT\u7684\u53c2\u8003\u8303\u56f4\u4e3a0\u81f313\u00b5g\/L\u3002MCT\u77ed\u6682\u5347\u9ad8\uff0c\u8bc1\u5b9e\u662f\u8fc7\u654f\u53cd\u5e94\u3002\u8fdb\u4e00\u6b65\u7684\u6d4b\u8bd5\u8868\u660e\u75c5\u4eba\u786e\u5b9e\u5bf9\u5934\u5b62\u544b\u8f9b\u8fc7\u654f(\u7b2c27\u7ae0<\/span>)\u3002\u51e0\u5468\u540e\u518d\u6b21\u5c1d\u8bd5\u8be5\u64cd\u4f5c\u3002\u7ed9\u4e88\u4e0d\u540c\u7684\u6297\u751f\u7d20\uff0c\u6ca1\u6709\u95ee\u9898\u3002<\/p>\n

\u8fd1\u671f\u5347\u9ad8\u7684MCT\u53ef\u4f5c\u4e3a\u8fc7\u654f\u53cd\u5e94\u7684\u8bca\u65ad\u8bd5\u9a8c\u3002\u5f53\u75c7\u72b6\u6709\u51e0\u79cd\u53ef\u80fd\u7684\u539f\u56e0\u65f6\uff0c\u8fd9\u4e00\u70b9\u5f88\u91cd\u8981\u3002\u8fd9\u91cc\u63cf\u8ff0\u7684\u60c5\u51b5\u4e2d\uff0c\u8840\u538b\u4e0b\u964d\u53ef\u80fd\u662f\u7531\u51fa\u8840\u5f15\u8d77\u7684\uff0c\u800c\u60a3\u8005\u7684\u901a\u6c14\u56f0\u96be\u53ef\u80fd\u662f\u7531\u4e8e\u6c14\u7ba1\u5bfc\u7ba1\u7684\u9519\u4f4d\u9020\u6210\u7684\u3002\u77ed\u6682\u5347\u9ad8\u7684MCT\u5219\u5f3a\u70c8\u8868\u660e\u8fc7\u654f\u53cd\u5e94\u662f\u539f\u56e0\u6240\u5728\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Box22.2 <\/span>\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u75c7<\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

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43\u5c81\u7684\u7537\u5b50\u4ece\u4e1c\u5357\u4e9a\u7684\u6d77\u5916\u63f4\u52a9\u5de5\u4f5c\u4e2d\u5f52\u6765\uff0c\u4ed6\u53c2\u4e0e\u4e86\u6c61\u6c34\u5904\u7406\u7cfb\u7edf\u7684\u5f00\u53d1\u3002\u56de\u5bb6\u540e\u88ab\u8981\u6c42\u63a5\u53d7\u4f53\u68c0\uff0c\u68c0\u67e5\u671f\u95f4\u53d1\u73b0\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u5347\u9ad8(2.5\u00d7106mL\uff0c\u6b63\u5e38\u8303\u56f4\u5e94<0.35\u00d7106mL)\u548c\u809d\u529f\u80fd\u5f02\u5e38(Fig22.14<\/span>)\u3002<\/p>\n

\u867d\u7136\u8fc7\u654f\u662f\u53d1\u8fbe\u56fd\u5bb6\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u75c7\u7684\u6700\u5e38\u89c1\u539f\u56e0\uff0c\u4f46\u8be5\u60a3\u8005\u6ca1\u6709\u54ee\u5598\u3001\u9f3b\u708e\u6216\u6e7f\u75b9\u7b49\u8fc7\u654f\u75c7\u72b6\u6216\u4f53\u5f81\u3002\u4ed6\u4e5f\u6ca1\u6709\u4efb\u4f55\u764c\u75c7\u7684\u7279\u5f81\uff0c\u764c\u75c7\u6709\u65f6\u4e0e\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u75c7\u6709\u5173\uff0c\u6bd4\u5982\u6dcb\u5df4\u7624\u3002\u809d\u810f\u6d3b\u68c0\u663e\u793a\u5bc4\u751f\u866b\u5375\u88ab\u8089\u82bd\u80bf\u5305\u56f4\u3002\u8bca\u65ad\u4e3a\u5bc4\u751f\u866b\u611f\u67d3\u6027\u8840\u5438\u866b\u75c5\uff0c\u60a3\u8005\u63a5\u53d7\u6cbb\u7597\u7684\u6548\u679c\u826f\u597d\u3002<\/p>\n

\u66fc\u6c0f\u8840\u5438\u866b\u662f\u4e16\u754c\u4e00\u4e9b\u5730\u533a\u5e38\u89c1\u7684\u5bc4\u751f\u866b\u3002\u5f53\u5e7c\u866b\u4ece\u53d7\u6c61\u67d3\u7684\u6c34\u6e90\u7a7f\u900f\u76ae\u80a4\u65f6\uff0c\u4eba\u7c7b\u5c31\u4f1a\u53d7\u5230\u611f\u67d3\u3002\u6210\u866b\u751f\u6d3b\u5728\u95e8\u9759\u8109\u4e2d\uff0c\u6392\u51fa\u5375\u5b50\uff0c\u5375\u5b50\u53ef\u5bc4\u5bbf\u5728\u809d\u810f\u5185\u3002\u80a5\u5927\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u80fd\u591f\u5229\u7528\u4e0a\u8ff0\u673a\u5236\u6740\u6b7b\u8840\u5438\u866b\u548c\u5b83\u4eec\u7684\u5375\u3002\u660e\u663e\u7684\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u662f\u8fd9\u4e9b\u7ec6\u80de\u6d3b\u5316\u7684\u53cd\u6620\u3002\u5f53\u5375\u5b50\u89e3\u4f53\u65f6\uff0c\u5b83\u4eec\u4f1a\u91ca\u653e\u591a\u80bd\uff0c\u8fd9\u4e9b\u591a\u80bd\u88abTH1\u7ec6\u80de\u5904\u7406\u5e76\u8bc6\u522b\u4e3a\u5e38\u89c4\u6297\u539f\u3002\u672a\u7ecf\u6cbb\u7597\u7684\u8840\u5438\u866b\u75c5\u4f1a\u5bfc\u81f4\u809d\u810f\u6162\u6027\u708e\u75c7\uff0c\u662f\u809d\u786c\u5316\u7684\u539f\u56e0\u4e4b\u4e00\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8fd9\u79cd\u635f\u5bb3\u662f\u7531\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u5bf9\u6210\u866b\u7684\u53cd\u5e94\u8fd8\u662fTH1\u7ec6\u80de\u5bf9\u866b\u5375\u7684\u53cd\u5e94\uff0c\u8fd8\u662f\u4e24\u8005\u517c\u800c\u6709\u4e4b\u3002<\/p>\n<\/section>\n<\/section>\n

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Fig 22.14<\/span> \u55dc\u9178\u6027\u7c92\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u7684\u591a\u53f6\u6838\u8868\u660e\u5b83\u4eec\u4e0e\u4e2d\u6027\u7c92\u7ec6\u80de\u5173\u7cfb\u5bc6\u5207(\u89c1Fig21.1A<\/span>)\u3002\u6ce8\u610f\u7c97\u5927\u7684\u7ea2\u8272\u9897\u7c92\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u738b\u60e0\u742a  \u90d1\u68a6\u6021 \u7f57\u4f73\u4f73 \u949f\u96ea\u83b9<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u7f57\u4f73\u4f73<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u9648\u79cb\u8c37 \u5b8b\u4e50<\/span><\/section>\n
\u7ec8\u5ba1 | \u738b\u5764<\/span> \u8096\u5efa\u52c7<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

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\u2589  \u5f80\u671f\u6587\u7ae0\u76ee\u5f55<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c21\u7ae0\uff1a\u541e\u566c\u7ec6\u80de<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c20\u7ae0\uff1a\u56fa\u6709\u514d\u75ab\u7684\u9632\u5fa1\u4f5c\u7528<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c19\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u751f\u7406\u529f\u80fd\u7b80\u8ff0<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c1\u7ae0\uff1a\u80bf\u7624\u514d\u75ab\u7b80\u53f2<\/span><\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/span><\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

TCGA\u514d\u75ab\u6d78\u6da6\u8bc4\u4ef7\u6570\u636e\u5e93<\/a>
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ggplot2|\u8be6\u89e3\u516b\u5927\u57fa\u672c\u7ed8\u56fe\u8981\u7d20<\/a>
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Python\u96c6\u6210\u5f00\u53d1\u73af\u5883PyCharm\u7684\u5b89\u88c5\u4e0e\u6fc0\u6d3b<\/a>
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Python\u53d1\u884c\u7248Anaconda\u7684\u5b89\u88c5\u4e0e\u4f7f\u7528<\/a><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
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Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
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\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
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HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
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PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
<\/p>\n

\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
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Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
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\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
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PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
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\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n

\u5065\u5eb7\u517b\u751f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u516b\u6bb5\u9526\uff08\u89c6\u9891\u7248+\u56fe\u7247\u7248\uff0c\u63a8\u8350\u6536\u85cf\uff09<\/a><\/span><\/p>\n


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\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n


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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n


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\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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