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Table24.1<\/span>\u6309\u7ec6\u80de\u56e0\u5b50\u7684\u4e00\u822c\u4f5c\u7528\u5217\u51fa\u4e86\u4e00\u4e9b\u91cd\u8981\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u6ce8\u610f\u6709\u591a\u5c11\u7ec6\u80de\u56e0\u5b50\u8fde\u63a5\u4e86\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u548c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table24.1 <\/span>\u7ec6\u80de\u56e0\u5b50\u53ca\u5176\u4e00\u822c\u6548\u5e94\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u548c\u4fe1\u53f7\u5206\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5927\u591a\u6570\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u5c5e\u4e8e\u4ee5\u4e0b\u4e09\u4e2a\u5bb6\u65cf\u3002\u8fd9\u4e9b\u53d7\u4f53\u5bb6\u65cf\u4e2d\u7684\u6bcf\u4e00\u4e2a\u90fd\u4e0e\u4e0d\u540c\u7684\u4fe1\u53f7\u8f6c\u5bfc\u5206\u5b50\u76f8\u8fde\uff0c\u4fe1\u53f7\u8f6c\u5bfc\u5206\u5b50\u5c06\u4fe1\u53f7\u4ece\u53d7\u4f53\u4f20\u9012\u5230\u7ec6\u80de\u5185\u90e8\u3002\u8fd9\u4e9b\u7279\u6027\u4e0e\u8fde\u63a5T\u7ec6\u80de\u548cB\u7ec6\u80de\u53d7\u4f53\u7684\u4fe1\u53f7\u8f6c\u5bfc\u673a\u5236\u6709\u4e00\u4e9b\u76f8\u540c\u4e4b\u5904(\u7b2c11\u7ae0<\/span>)\u3002\u4e3b\u8981\u6709\u4e09\u7c7b\u53d7\u4f53\uff1a(1)\u5e38\u89c1\u7684\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u5bb6\u65cf\uff1b(2)\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\uff1b(3)\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5927\u591a\u6570\u7ec6\u80de\u56e0\u5b50\u4f7f\u7528\u5171\u540c\u7684\u53d7\u4f53\u5206\u5b50\uff0c\u5982\u751f\u957f\u56e0\u5b50\u548c\u5e72\u6270\u7d20\u7684\u53d7\u4f53\uff0c\u8be5\u53d7\u4f53\u6709\u65f6\u88ab\u79f0\u4e3a\u9020\u8840\u56e0\u5b50\u53d7\u4f53\u3002\u5e38\u89c1\u7684\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u7531\u4e00\u4e2a\u6216\u591a\u4e2a\u8de8\u819c\u5206\u5b50\u7ec4\u6210\uff0c\u8fd9\u4e9b\u8de8\u819c\u5206\u5b50\u5177\u6709\u7279\u5b9a\u7ec6\u80de\u56e0\u5b50\u7684\u7279\u5f02\u6027\u80de\u5916\u533a\u3002IL-2\u3001IL-4\u548cIL-7\u7684\u53d7\u4f53\u7531\u4e09\u4e2a\u72ec\u7acb\u7684\u591a\u80bd\u94fe\u7ec4\u6210\uff0c\u4f46\u5171\u4eab\u4e00\u4e2a\u03b3\u94fe\u3002\u5728X\u8fde\u9501<\/span>\u8054\u5408\u514d\u75ab\u7f3a\u9677\u75c5(SCID)\u4e2d\uff0c\u03b3\u94fe\u57fa\u56e0\u5b58\u5728\u7f3a\u9677\u3002BOX 12.2<\/span>\u63cf\u8ff0\u4e86\u8fd9\u79cd\u60c5\u51b5\u7684\u4e34\u5e8a\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5927\u591a\u6570\u5e38\u89c1\u7684\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u5728\u5b8c\u5168\u9759\u6b62\u7684\u7ec6\u80de\u4e2d\u4e0d\u4f1a\u5927\u91cf\u8868\u8fbe\uff0c\u800c\u662f\u5728\u7ec6\u80de\u88ab\u6fc0\u6d3b\u540e\u8868\u8fbe\u624d\u4e0a\u8c03\uff0c\u4f8b\u5982T\u7ec6\u80de\u901a\u8fc7T\u7ec6\u80de\u53d7\u4f53\u6fc0\u6d3b\uff0c\u7ec6\u80de\u53d7\u4f53\u8868\u8fbe\u4e0a\u8c03\u3002\u5b83\u4eec\u901a\u5e38\u5206\u5e03\u5728\u7ec6\u80de\u8868\u9762\u3002\u5f53\u7ec6\u80de\u56e0\u5b50\u4e0e\u5176\u53d7\u4f53\u7ed3\u5408\u65f6\uff0c\u4f1a\u5bfc\u81f4\u53d7\u4f53\u5728\u7ec6\u80de\u8868\u9762\u805a\u96c6\u3002Janus\u6fc0\u9176(JAKs)\uff0c\u4e00\u79cd\u916a\u6c28\u9178\u6fc0\u9176\uff0c\u901a\u5e38\u4e0e\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u7684\u80de\u6d46\u90e8\u5206\u76f8\u5173\uff0c<\/span>\u5f53JAKs\u6563\u5e03\u5728\u7ec6\u80de\u65f6\uff0c\u4ecd\u7136\u5904\u4e8e\u4e0d\u6d3b\u8dc3\u72b6\u6001\u3002\u800c\u5f53\u53d7\u4f53\u901a\u8fc7\u7ec6\u80de\u56e0\u5b50\u7ed3\u5408\u5728\u4e00\u8d77\u65f6\uff0cJAK\u9176\u88ab\u6fc0\u6d3b\uff0c\u7136\u540e\u5b83\u4eec\u5171\u540c\u78f7\u9178\u5316\u51e0\u79cd\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50(STATs)\u4e2d\u7684\u4e00\u79cd\u3002\u4e00\u65e6STAT\u5206\u5b50\u88ab\u78f7\u9178\u5316\uff0c\u5b83\u4eec\u5c31\u4f1a\u5f62\u6210\u4e8c\u805a\u4f53\uff0c\u8fc1\u79fb\u5230\u7ec6\u80de\u6838\uff0c\u5e76\u6fc0\u6d3b\u7279\u5b9a\u57fa\u56e0\u7684\u8f6c\u5f55\u3002\u6709\u591a\u79cdJAK\u548cSTAT\u5206\u5b50\u3002\u4f8b\u5982\uff0c\u5f53IL-2\u4e0e\u6fc0\u6d3b\u7684T\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u7ed3\u5408\u65f6\uff0c\u5b83\u4f1a\u6fc0\u6d3bJAK5\u3001STAT1\u548cSTAT3\u3002\u5f53\u8fd9\u4e9b\u5206\u5b50\u8fc1\u79fb\u5230\u7ec6\u80de\u6838\u65f6\uff0c\u5b83\u4eec\u4f1a\u6fc0\u6d3b\u542f\u52a8T\u7ec6\u80de\u589e\u6b96\u7684\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5f53\u514d\u75ab\u53cd\u5e94\u63a5\u8fd1\u5c3e\u58f0\u65f6\uff0c\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u4e0b\u964d\uff0c\u4e0d\u518d\u4e0e\u53d7\u4f53\u7ed3\u5408\uff0c\u57fa\u56e0\u8f6c\u5f55\u56e0\u6b64\u7ed3\u675f\u3002\u8d8b\u5316\u56e0\u5b50\u662f\u4e00\u5927\u7c7b\u7ec6\u80de\u56e0\u5b50\uff0c\u4e4b\u524d\u5df2\u7ecf\u63d0\u8fc7\u5b83\u4e0e\u8d8b\u5316\u7ec6\u80de\u8fdb\u5165\u708e\u75c7\u7ec4\u7ec7\u6709\u5173(\u7b2c13\u7ae0<\/span>\u548c\u7b2c21\u7ae0<\/span>)\u3002\u5b83\u4eec\u4e5f\u5728\u767d\u7ec6\u80de\u56de\u5de2<\/span>\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u6dcb\u5df4\u7ed3\u7ec6\u80de\u5206\u6ccc\u7684\u8d8b\u5316\u56e0\u5b50\u5c06B\u7ec6\u80de\u8d8b\u5316\u81f3\u751f\u53d1\u4e2d\u5fc3\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u533a\u57df\uff0c\u5e76\u5c06T\u7ec6\u80de\u8d8b\u5316\u5230T\u7ec6\u80de\u533a\u57df(\u7b2c13\u7ae0<\/span>)\u3002\u8981\u5b9e\u73b0\u8fd9\u4e9b\u590d\u6742\u7684\u4fe1\u53f7\u4f20\u9012\uff0c\u9700\u8981\u5927\u7ea6\u670950\u79cd\u4e0d\u540c\u7684\u8d8b\u5316\u56e0\u5b50\u548c\u5927\u7ea620\u79cd\u4e0d\u540c\u7684\u53d7\u4f53\u3002\u5927\u591a\u6570\u53d7\u4f53\u53ef\u4ee5\u4e0e\u51e0\u79cd\u4e0d\u540c\u7684\u8d8b\u5316\u56e0\u5b50\u7ed3\u5408\uff0c\u540c\u65f6\u8bb8\u591a\u8d8b\u5316\u56e0\u5b50\u53ef\u4ee5\u4e0e\u4e0d\u540c\u7684\u53d7\u4f53\u7ed3\u5408\u3002\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u662f\u8de8\u8d8a\u7ec6\u80de\u819c7\u6b21\u7684\u03b1\u87ba\u65cb(Fig 24.2<\/span>)\uff0c\u5728\u7ed3\u5408\u8d8b\u5316\u56e0\u5b50\u65b9\u9762\uff0c\u53d7\u4f53\u50ac\u5316\u9e1f\u82f7\u4e09\u78f7\u9178(GTP)\u53d6\u4ee3\u9e1f\u82f7\u4e8c\u78f7\u9178(GDP)\u3002\u540c\u65f6\uff0c\u4e00\u79cd\u7279\u5b9a\u7684\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u88ab\u7528\u4f5cHIV\u7684\u8f85\u52a9\u53d7\u4f53(\u7b2c33\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TNF\u53d7\u4f53\u5bb6\u65cf\u6bd4\u8f83\u7279\u6b8a\u3002TNF\u662f\u5206\u6ccc\u6027\u3001\u4ee5\u819c\u7ed3\u5408\u5f62\u5f0f\u53d1\u6325\u6d3b\u6027\uff0c\u4e5f\u53ef\u4ee5\u4ece\u5206\u6ccc\u7ec6\u80de\u7684\u819c\u4e0a\u88c2\u89e3\u51fa\u6765\uff0c\u7136\u540e\u81ea\u7531\u5730\u53d1\u6325\u5c40\u90e8\u6216\u8fdc\u7a0b\u6548\u5e94\u3002\u4e0e\u7ec6\u80de\u7ed3\u5408\u548c\u6e38\u79bb\u7684TNF\u90fd\u4ee5\u4e09\u805a\u4f53\u7684\u5f62\u5f0f\u5b58\u5728\uff0c\u5e76\u4e0e\u4e24\u79cd\u53d7\u4f53\u4e2d\u7684\u4e00\u79cd\u7ed3\u5408\uff0c\u8fd9\u4e24\u79cd\u53d7\u4f53\u4e5f\u662f\u4e09\u805a\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TNF\u53caTNF\u53d7\u4f53\u5bb6\u65cf\u7684\u53e6\u5916\u4e24\u4e2a\u91cd\u8981\u6210\u5458CD40\u548cCD40\u914d\u4f53(CD154)\u5df2\u7ecf\u88ab\u8ba8\u8bba\u8fc7\u3002\u8fd9\u5bf9\u5171\u523a\u6fc0\u5206\u5b50\u53c2\u4e0eT\u7ec6\u80de\u4e0eB\u7ec6\u80de\u6216\u4e0e\u6297\u539f\u63d0\u5448\u7ec6\u80de(APC)\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u53e6\u4e00\u5bf9\u662fFas\u548cFas\u914d\u4f53(FasL\uff1bTable24.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u7684\u4f5c\u7528\u53d6\u51b3\u4e8e\u5b83\u7ed3\u5408\u7684\u9776\u7ec6\u80de\u3002\u5982\u7b2c22\u7ae0<\/span>\u6240\u8ff0\uff0c\u5f53TNF\u4e0e\u53d7\u611f\u67d3\u7684\u7ec6\u80de\u7ed3\u5408\u65f6\uff0c\u5b83\u901a\u8fc7\u81ea\u8eab\u7684\u6b7b\u4ea1\u7ed3\u6784\u57df\u53c2\u4e0e\u8bf1\u5bfc\u534a\u80f1\u6c28\u9178\u5929\u51ac\u6c28\u9178\u9176(caspases)\u4f9d\u8d56\u7684\u51cb\u4ea1\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5f53\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u4e0e\u5de8\u566c\u7ec6\u80de\u6216\u5185\u76ae\u7ec6\u80de\u7ed3\u5408\u65f6\uff0c\u5b83\u901a\u8fc7\u4e0e\u4e00\u7ec4\u80fd\u591f\u6fc0\u6d3b\u6838\u56e0\u5b50\u03baB(NF-\u03baB)\u7684\u7279\u6b8a\u63a5\u5934\u5206\u5b50\u7ed3\u5408\u6765\u8bf1\u5bfc\u57fa\u56e0\u8f6c\u5f55\u3002Fas-FasL\u7ed3\u5408\u53ea\u8bf1\u5bfc\u9776\u7ec6\u80de\u51cb\u4ea1\uff0c\u4f46\u8fd9\u79cd\u8bf1\u5bfc\u73b0\u8c61\u5f88\u5e38\u89c1\u3002CD40\/CD154(CD40\u914d\u4f53)\u7ed3\u5408\u8bf1\u5bfc\u57fa\u56e0\u8f6c\u5f55\uff0c\u5728T\u7ec6\u80de\u4e0eAPC\u6216B\u7ec6\u80de\u7684\u901a\u8baf\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528(Fig 24.3<\/span>)\u3002\u7b2c16\u7ae0<\/span>\u8ba8\u8bba\u4e86CD154\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u6297\u4f53\u7f3a\u9677\u7684\u73b0\u8c61\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 24.1 <\/span>\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u4e2d\u7684\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u5bb6\u65cf\u548c\u76f8\u5173\u4fe1\u53f7\u5206\u5b50\u7684\u4e3b\u8981\u7279\u5f81<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 24.2 <\/span>\u5178\u578b\u7684\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table24.2<\/span>  \u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u5bb6\u65cf\u6210\u5458\u53ca\u5176\u53d7\u4f53<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u7ec6\u80de\u56e0\u5b50\u5728\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u4e00\u4e9b\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u6025\u6027\u708e\u75c7\uff1a\u611f\u67d3\u7684\u65e9\u671f\u53cd\u5e94<\/strong><\/p>\n<\/section>\n

\n
\n
\n

\u5165\u4fb5\u7684\u75c5\u539f\u4f53\u5bf9\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u7ec6\u80de\u5448\u9012\u75c5\u539f\u4f53\u76f8\u5173\u5206\u5b50\u6a21\u5f0f(PAMPs)\uff0c\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7\u4ea7\u751f\u5371\u9669\u4fe1\u53f7(\u4e3b\u8981\u662f\u5206\u6ccc\u7684\u7ec6\u80de\u56e0\u5b50)\u5bf9\u5165\u4fb5\u7684\u75c5\u539f\u4f53\u4f5c\u51fa\u53cd\u5e94\u3002\u5bf9\u4e8e\u7ec6\u80de\u5916\u7ec6\u83cc\u6216\u771f\u83cc\uff0c\u541e\u566c\u7ec6\u80de\u901a\u8fc7Toll\u6837\u53d7\u4f53(TLR)\u8bc6\u522b\uff0c\u7136\u540e\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50IL-1\u3001TNF\u3001\u7c92\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50(G-CSF)\u548cIL-6\u3002\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u53ef\u4ee5\u523a\u6fc0\u5c40\u90e8\u708e\u75c7\uff0c\u5e76\u53ef\u80fd\u4fc3\u8fdb\u6025\u6027\u671f\u53cd\u5e94\u7684\u53d1\u5c55\u3002\u901a\u5e38\uff0c\u6025\u6027\u671f\u53cd\u5e94\u7684\u5168\u8eab\u6027\u7279\u5f81\u6709\u53d1\u70e7\u3001\u767d\u7ec6\u80de\u6570\u91cf\u589e\u591a\u3001\u98df\u6b32\u4e0d\u632f\u548c\u673a\u4f53\u4e0d\u9002\u3002\u5728\u6700\u6781\u7aef\u7684\u60c5\u51b5\u4e0b\uff0c\u6025\u6027\u671f\u53cd\u5e94\u53ef\u80fd\u4f1a\u5bfc\u81f4\u611f\u67d3\u6027\u4f11\u514b(\u7b2c21\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5de8\u566c\u7ec6\u80de\u548c\u4ee5\u53ca\u5c40\u90e8\u7684\u4e00\u4e9b\u5176\u4ed6\u7ec6\u80de\u53ef\u4ee5\u5206\u6ccc\u4ee5IL-8\u4e3a\u4e3b\u7684\u4e00\u4e9b\u8d8b\u5316\u56e0\u5b50\uff0c\u8fd9\u4e9b\u8d8b\u5316\u56e0\u5b50\u53ef\u5c06\u4e2d\u6027\u7c92\u7ec6\u80de\u8d8b\u5316\u5230\u611f\u67d3\u90e8\u4f4d\u3002\u8fd9\u4e9b\u7ec6\u80de\u8fd8\u53ef\u4ee5\u5206\u6cccIL-23\u6765\u523a\u6fc0TH17\u7ec6\u80de\u7684\u6d3b\u5316\u3002\u5982\u679c\u5bbf\u4e3b\u518d\u6b21\u63a5\u89e6\u76f8\u540c\u7684\u75c5\u539f\u4f53\uff0cTH17\u4f1a\u5206\u6cccIL-17\uff0cIL-17\u5728\u8d8b\u5316\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u523a\u6fc0\u4e0a\u76ae\u7ec6\u80de\u5206\u6ccc\u6297\u83cc\u80bd\u65b9\u9762\u5177\u6709\u663e\u8457\u4f5c\u7528\u3002\u75c5\u6bd2\u611f\u67d3\u65f6\u60c5\u51b5\u5c31\u4e0d\u540c\u4e86\uff0cI\u578b\u5e72\u6270\u7d20\u7684\u5206\u6ccc\u5360\u4e3b\u5bfc\u5730\u4f4d\u3002I\u578b\u7ec6\u80de\u56e0\u5b50\u5177\u6709\u76f4\u63a5\u7684\u6297\u75c5\u6bd2\u4f5c\u7528\uff0c\u53ef\u589e\u5f3a\u6297\u539f\u63d0\u5448\u548cTH1\u53cd\u5e94\u7684\u53d1\u751f\u3002I\u578b\u7ec6\u80de\u56e0\u5b50\u4e5f\u4f1a\u89e6\u53d1\u6025\u6027\u671f\u53cd\u5e94(\u89c1BOX 24.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 24.3 <\/span>\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)\u5bb6\u65cf\u6210\u5458\u4e0e\u5176\u53d7\u4f53\u7ed3\u5408\u7684\u4e0d\u540c\u4f5c\u7528<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

T\u7ec6\u80de\u7684\u6d3b\u5316<\/strong><\/p>\n<\/section>\n

\n
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\u63a5\u4e0b\u6765\u7684\u8fc7\u7a0b\u53d1\u751f\u5728\u5f15\u6d41\u611f\u67d3\u90e8\u4f4d\u6dcb\u5df4\u7ed3\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u63d0\u5448\u6297\u539f\uff0c\u5e76\u88ab\u8868\u8fbe\u76f8\u5bf9\u5e94\u7684\u53d7\u4f53\u7684T\u7ec6\u80de\u8bc6\u522b\u3002\u6b63\u5982\u7b2c16\u7ae0<\/span>\u6240\u8ba8\u8bba\u7684\uff0c\u53ea\u6709\u5f53APC\u4f9d\u65e7\u4ee5\u8868\u9762\u5206\u5b50(CD40\u3001CD80\u3001\u7ec6\u80de\u95f4\u7c98\u9644\u5206\u5b50[ICAM])\u7684\u5f62\u5f0f\u63d0\u4f9b\u5171\u523a\u6fc0\u65f6\uff0cTH\u7ec6\u80de\u624d\u4f1a\u88ab\u6fc0\u6d3b\u3002APC\u8fd8\u80fd\u5206\u6ccc\u5171\u523a\u6fc0\u7ec6\u80de\u56e0\u5b50\uff0c\u5305\u62ecIL-1\u548cIFN-I\uff0c\u8fd9\u4e24\u79cd\u56e0\u5b50\u90fd\u6709\u52a9\u4e8e\u6d3b\u5316T\u7ec6\u80de\u3002\u88ab\u6fc0\u6d3b\u7684\u8f85\u52a9\u6027T\u7ec6\u80de\u4e0a\u8c03IL-2\u53d7\u4f53\uff0c\u5e76\u5f00\u59cb\u5206\u6cccIL-2\u3002\u5728IL-2\u4e0e\u5176\u53d7\u4f53\u7ed3\u5408\u4e4b\u524d\uff0cTH\u7ec6\u80de\u4e0d\u4f1a\u589e\u6b96\u3002IL-2\u53ef\u80fd\u662f\u7531\u7ec6\u80de\u81ea\u5206\u6ccc\uff0c\u4e5f\u53ef\u80fd\u662f\u7531\u90bb\u8fd1\u7684T\u7ec6\u80de\u65c1\u5206\u6ccc\uff1b\u4efb\u4f55\u4e00\u79cd\u60c5\u51b5\u90fd\u53ef\u80fd\u5bfc\u81f4T\u7ec6\u80de\u514b\u9686\u7684\u6269\u589e\u3002\u540e\u7eed\u8fc7\u7a0b\u53d6\u51b3\u4e8e\u89e6\u53d1\u5e94\u7b54\u7684\u75c5\u539f\u4f53\u7c7b\u578b\u548c\u5e94\u7b54\u7684\u4f4d\u7f6e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u7279\u5f02\u6027T\u7ec6\u80de\u5e94\u7b54\u7684\u7814\u7a76\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n

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\u80a0\u9053\u514d\u75ab\u529b<\/strong><\/p>\n<\/section>\n

\n
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\u80a0\u6e90\u6027T\u7ec6\u80de\u5206\u6ccc\u4e00\u79cd\u53eb\u505a\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2(TGF-\u03b2)\u7684\u7ec6\u80de\u56e0\u5b50\u3002TGF-\u03b2\u53ef\u8bf1\u5bfc\u514d\u75ab\u7403\u86cb\u767d(Ig)\u7684\u7c7b\u578b\u7531IgM\u578b\u5411IgA\u578b\u8f6c\u53d8\uff0c\u8fd9\u4e00\u53cd\u5e94\u5728\u7c98\u819c\u514d\u75ab\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002TGF-\u03b2\u8fd8\u5177\u6709\u5f3a\u5927\u7684\u6297\u708e\u4f5c\u7528\u548c\u6291\u5236\u5927\u591a\u6570T\u7ec6\u80de\u7fa4\u3001\u5de8\u566c\u7ec6\u80de\u548c\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u4f5c\u7528\u3002TGF-\u03b2\u53ef\u8bf1\u5bfcT\u7ec6\u80de\u5206\u5316\u6210\u8c03\u8282\u6027T\u7ec6\u80de(Tregs)\u3002\u6700\u7ec8\uff0c\u80a0\u9053\u4e2d\u5927\u90e8\u5206\u514d\u75ab\u53cd\u5e94\u504f\u5411\u4e8e\u4ea7\u751fIgA\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TH17\u53cd\u5e94<\/strong><\/p>\n<\/section>\n

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\u7ec6\u83cc\u548c\u771f\u83cc\u7b49\u7ec6\u80de\u5916\u75c5\u539f\u4f53\u523a\u6fc0\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4ea7\u751fIL-23\uff0cIL-23\u523a\u6fc0TH17\u578bT\u7ec6\u80de\u7684\u4ea7\u751f\u3002\u8fd9\u4e9bT\u7ec6\u80de\u5206\u6ccc\u7684IL-17\u5728\u52df\u96c6\u4e2d\u6027\u7c92\u7ec6\u80de\u5230\u611f\u67d3\u90e8\u4f4d\u8fc7\u7a0b\u4e2d\u8d77\u663e\u8457\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TH1\u53cd\u5e94<\/strong><\/p>\n<\/section>\n

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\u7ec6\u80de\u5185\u75c5\u539f\u4f53\u523a\u6fc0APC\u5206\u6cccIL-12\u548cIFN-I\uff0c\u5b83\u4eec\u53ef\u8bf1\u5bfcT\u7ec6\u80de\u8f6c\u5f55\u56e0\u5b50T-bet\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u5bfc\u81f4\u5e72\u6270\u7d20-\u03b3\u7684\u5206\u6ccc\u548cTh1\u8868\u578b\u7684\u4ea7\u751f(\u7b2c16\u7ae0<\/span>)\u3002Th1\u7ec6\u80de\u6709\u5229\u4e8eB\u7ec6\u80de\u4ea7\u751fIgG\uff0c\u7136\u540e\u6fc0\u6d3b\u6d3b\u5316\u7684\u541e\u566c\u7ec6\u80de\u7684\u541e\u566c\u529f\u80fd\u3002\u4f5c\u4e3aB\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u7684IL-6\u53ef\u4ee5\u4fc3\u8fdbB\u7ec6\u80deIgG\u7684\u4ea7\u751f\u3002\u5f53\u7ec6\u80de\u5185\u7684\u75c5\u539f\u4f53\u4e0d\u80fd\u88ab\u6e05\u9664\u65f6\uff0c\u4f1a\u6709\u5927\u91cf\u989d\u5916\u7684TNF\u5206\u6ccc\uff0c\u4ece\u800c\u5bfc\u81f4\u8089\u82bd\u80bf\u7684\u4ea7\u751f(\u7b2c23\u7ae0<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TH2\u53cd\u5e94<\/strong><\/p>\n<\/section>\n

\n
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\u5f13\u5f62\u866b\u611f\u67d3\u503e\u5411\u4e8eTH2\u53cd\u5e94\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695aAPC\u5728\u5e94\u5bf9\u5f13\u5f62\u866b\u611f\u67d3\u65f6\u4ea7\u751f\u4e86\u4ec0\u4e48\u8bf1\u5bfc\u4fe1\u53f7\uff0c\u4f46T\u7ec6\u80de\u8f6c\u5f55\u56e0\u5b50GATA3\u88ab\u8bf1\u5bfc\u6fc0\u6d3b\u5e76\u5bfc\u81f4IL-4\u7684\u5206\u6ccc\u3002IL-4\u4fc3\u8fdbB\u7ec6\u80de\u4ea7\u751fIgE\uff0c\u4ece\u800c\u6fc0\u6d3b\u80a5\u5927\u7ec6\u80de\uff0c\u8fdb\u800c\u4ea7\u751f\u66f4\u591a\u7684IL-4\u3002\u6b64\u5916\uff0cTH2\u7ec6\u80de\u8fd8\u5206\u6ccc\u5176\u4ed6\u7ec6\u80de\u56e0\u5b50\u5982IL-5\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8d8b\u5316\u56e0\u5b50\uff0c\u5b83\u4eec\u53ef\u901a\u8fc7\u523a\u6fc0\u80a5\u5927\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u7684\u6210\u719f\u6765\u5e2e\u52a9\u7ef4\u6301TH2\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de(Tregs)\u662f\u5916\u5468\u8010\u53d7\u7684\u4e00\u90e8\u5206\uff0c\u80fd\u9632\u6b62\u673a\u4f53\u5bf9\u81ea\u8eab\u6297\u539f\u4ea7\u751f\u53cd\u5e94\uff0c\u5b83\u4eec\u5206\u6cccIL-10\u548cTGF-\u03b2\u3002T\u7ec6\u80de\u5229\u7528\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u6291\u5236\u673a\u4f53\u5bf9\u81ea\u8eab\u6297\u539f\u4ea7\u751f\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u514d\u75ab\u53cd\u5e94\u7684\u7ec8\u6b62<\/strong><\/p>\n<\/section>\n

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\u4e00\u65e6\u75c5\u539f\u4f53\u88ab\u6e05\u9664\uff0c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u6536\u5230\u7684\u5371\u9669\u4fe1\u53f7\u5c31\u4f1a\u4e0b\u964d\uff0cIL-1\u3001IFN-I\u548cTNF\u7b49\u7ec6\u80de\u56e0\u5b50\u7684\u6c34\u5e73\u4e5f\u4f1a\u4e0b\u964d\u3002\u6b64\u5916\uff0c\u53ef\u4f9b\u63d0\u5448\u7684\u6297\u539f\u4e5f\u4f1a\u51cf\u5c11\uff0cT\u7ec6\u80de\u523a\u6fc0\u4f5c\u7528\u51cf\u5f31\uff0c\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50\u751f\u6210\u51cf\u5c11\uff0c\u7ec6\u80de\u56e0\u5b50\u53d7\u4f53\u8868\u8fbe\u6c34\u5e73\u964d\u4f4e\u3002\u5f53IL-2\u6c34\u5e73\u4e0b\u964d\u663e\u8457\u65f6\uff0cT\u7ec6\u80de\u4ea7\u751f\u7684Bcl-2\u8f83\u5c11\uff0c\u5bb9\u6613\u53d1\u751f\u51cb\u4ea1\u3002\u4e0a\u8ff0\u8fd9\u4e9b\u56e0\u7d20\u5f80\u5f80\u4f1a\u964d\u4f4e\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u867d\u7136\u8bb0\u5fc6\u6027T\u7ec6\u80de\u7684\u6570\u91cf\u53ef\u80fd\u901a\u8fc7\u4f4e\u6c34\u5e73\u7684\u7ec4\u6210\u6027\u7684IL-7\u5206\u6ccc\u6765\u7ef4\u6301\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u6570\u91cf\u53ef\u901a\u8fc7\u7ec4\u6210\u6027\u7684G-CSF\u7684\u4ea7\u751f\u6765\u7ef4\u6301\uff0c\u4f46\u5728\u4e24\u6b21\u611f\u67d3\u4e4b\u95f4\uff0c\u4fc3\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u7684\u901a\u9053\u662f\u5173\u95ed\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 24.4 <\/span>\u7ec6\u80de\u56e0\u5b50\u5728\u514d\u75ab\u5e94\u7b54\u4e2d\u7684\u4f5c\u7528<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u56e0\u5b50\u53ca\u7ec6\u80de\u56e0\u5b50\u62ee\u6297\u5242\u7684\u4e34\u5e8a\u5e94\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u8840\u6db2\u4e2d\u7684\u6fc0\u7d20\u6c34\u5e73\u662f\u5e38\u89c4\u6d4b\u91cf\u4e2d\u7684\u4e00\u9879\u3002\u4f8b\u5982\uff0c\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u75c7\u662f\u901a\u8fc7\u4f4e\u6c34\u5e73\u7684\u7532\u72b6\u817a\u7d20\u6765\u8bca\u65ad\u7684\u3002\u7136\u800c\uff0c\u5728\u5e38\u89c4\u7684\u4e34\u5e8a\u5b9e\u8df5\u4e2d\uff0c\u4e0d\u4f1a\u6d4b\u91cf\u8840\u6db2\u4e2d\u7ec6\u80de\u56e0\u5b50\u7684\u6c34\u5e73\u3002\u8fd9\u662f\u56e0\u4e3a\u7ec6\u80de\u56e0\u5b50\u901a\u5e38\u4f5c\u7528\u4e8e\u975e\u5e38\u5c0f\u7684\u8303\u56f4\u5185\u3002\u4f8b\u5982\uff0c\u4f5c\u7528\u4e8e\u6dcb\u5df4\u7ed3\u4e2d\u7684\u751f\u53d1\u4e2d\u5fc3\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u5e76\u4e14\u4e0d\u4f1a\u6ea2\u51fa\u5230\u8840\u6db2\u4e2d\uff0c\u8fd9\u662f\u8377\u5c14\u8499\u548c\u7ec6\u80de\u56e0\u5b50\u4e4b\u95f4\u7684\u6839\u672c\u533a\u522b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u8840\u6db2\u4e2d\u53ef\u4ee5\u68c0\u6d4b\u5230\u7ec6\u80de\u56e0\u5b50\u7684\u5176\u4e2d\u4e00\u79cd\u60c5\u51b5\u662f\u673a\u4f53\u906d\u9047\u975e\u5e38\u4e25\u91cd\u7684\u611f\u67d3\u65f6\uff0c\u4f8b\u5982\u4e2d\u6bd2\u6027\u4f11\u514b\uff0c\u6b64\u65f6\u53ef\u80fd\u5728\u8840\u6db2\u4e2d\u53d1\u73b0\u9ad8\u6c34\u5e73\u7684TNF\u6216IL-6\u3002\u7136\u800c\uff0c\u5373\u4f7f\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0c\u76f8\u8f83\u6d4b\u91cf\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\uff0c\u6d4b\u91cf\u7531\u9ad8\u6c34\u5e73\u7ec6\u80de\u56e0\u5b50\u6240\u5bfc\u81f4\u7684\u9ad8\u70e7\u3001\u4f4e\u8840\u538b\u6216\u767d\u7ec6\u80de\u6570\u91cf\u5f02\u5e38\u7b49\u4e34\u5e8a\u8868\u73b0\u66f4\u5bb9\u6613\u5b9e\u73b0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6ce8\u610f\uff0c\u5728BOX 23.1<\/span>\u4e2d\u8ba8\u8bba\u7684\u5e72\u6270\u7d20-\u03b3\u91ca\u653e\u8bd5\u9a8c\u4e2d\uff0c\u5e72\u6270\u7d20-\u03b3\u4e0d\u662f\u5728\u8840\u6db2\u4e2d\u6d4b\u91cf\u7684\uff0c\u800c\u662f\u5728\u4f53\u5916\u523a\u6fc0\u60a3\u8005\u7684\u7ec6\u80de\u5206\u6ccc\u4e4b\u540e\u6d4b\u91cf\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7ec6\u80de\u56e0\u5b50\u6709\u65f6\u4e5f\u7528\u4f5c\u6cbb\u7597\u3002\u4f8b\u5982\uff0c\u4e59\u809d\u75c5\u6bd2\u611f\u67d3\u53ef\u4ee5\u7528\u91cd\u7ec4\u5e72\u6270\u7d20-\u03b1\u6cbb\u7597\uff0c\u4f46\u8fd9\u7ecf\u5e38\u4f1a\u4ea7\u751f\u95ee\u9898\uff0c\u66f4\u5e38\u89c1\u7684\u662f\u4f7f\u7528\u5355\u514b\u9686\u6297\u4f53\u963b\u65ad\u7ec6\u80de\u56e0\u5b50\u3002\u63a5\u4e0b\u6765\u7684\u51e0\u7ae0\u5c06\u8ba8\u8bba\u4f7f\u7528\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u7684\u4e00\u4e9b\u75be\u75c5\u3002\u76ee\u524d\u8981\u4e86\u89e3\u7684\u662f\u963b\u65ad\u7ec6\u80de\u56e0\u5b50\u662f\u5982\u4f55\u4f7f\u60a3\u8005\u5bb9\u6613\u53d7\u5230\u7279\u5b9a\u611f\u67d3\u7684\uff0c\u8fd9\u5728BOX 24.2<\/span>\u4e2d\u6709\u63cf\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

BOX 24.1 <\/span>\u5e72\u6270\u7d20-\u03b1\u6cbb\u7597\u7684\u526f\u4f5c\u7528<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

 <\/span>38\u5c81\uff0c\u5973\u6027\uff0c\u786e\u8bca\u4e3a\u7531\u4e59\u578b\u809d\u708e\u75c5\u6bd2(HBV)\u611f\u67d3\u5f15\u8d77\u7684\u6162\u6027\u809d\u708e\u3002\u4f7f\u7528\u91cd\u7ec4\u5e72\u6270\u7d20-\u03b1\u8fdb\u884c\u6cbb\u7597\uff0c\u5979\u6bcf\u5468\u53ea\u9700\u8981\u6ce8\u5c04\u4e00\u6b21\u201c\u805a\u4e59\u4e8c\u9187\u5316\u201d\u7684\u5e72\u6270\u7d20-\u03b1(\u7b2c36\u7ae0<\/span>)\u3002\u6ce8\u5c04\u540e\uff0c\u5979\u51fa\u73b0\u9ad8\u70e7(>40\u2103)\uff0c\u808c\u8089\u75bc\u75db\uff0c\u5e76\u98df\u6b32\u4e0d\u632f\u8fbe2\u5929\u3002\u8fd9\u79cd\u60c5\u51b5\u5728\u56db\u4e2a\u7597\u7a0b\u4e2d\u5747\u6709\u53d1\u751f\uff0c\u5176\u75c7\u72b6\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u75c5\u6bd2\u611f\u67d3\u7684\u7279\u5f81\uff0c\u4f46\u5728\u63a5\u53d7\u5e72\u6270\u7d20-\u03b1\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u7ea6\u670950%\u4e5f\u4f1a\u51fa\u73b0\u8fd9\u4e9b\u75c7\u72b6\u3002\u7ed9\u5979\u6539\u7528\u6297\u75c5\u6bd2\u836f\u7269\u540e\u526f\u4f5c\u7528\u6d88\u5931\uff0c5\u5e74\u540e\uff0c\u5979\u6062\u590d\u4e86\u6b63\u5e38\u5065\u5eb7\u3002<\/span><\/p>\n

\u5e72\u6270\u7d20-\u03b1\u56e0\u5176\u6297\u75c5\u6bd2\u4f5c\u7528\u800c\u88ab\u7528\u4e8e\u4e59\u578b\u809d\u708e\u7684\u6cbb\u7597\u3002\u7136\u800c\uff0c\u5e72\u6270\u7d20-\u03b1\u4e5f\u4f1a\u6fc0\u6d3b\u6025\u6027\u671f\u53cd\u5e94(\u7b2c20\u7ae0<\/span>)\u3002\u5728\u4e0b\u4e18\u8111\u4e2d\u5b58\u5728\u5e72\u6270\u7d20-\u03b1\u53d7\u4f53\uff0c\u56e0\u6b64\u5e72\u6270\u7d20-\u03b1\u6709\u53ef\u80fd\u76f4\u63a5\u5f15\u53d1\u6025\u6027\u671f\u53cd\u5e94\u3002\u6216\u8005\uff0c\u5e72\u6270\u7d20-\u03b1\u53ef\u4ee5\u901a\u8fc7\u523a\u6fc0T\u7ec6\u80de\u91ca\u653e\u767d\u7ec6\u80de\u4ecb\u7d206(IL-6)\u89e6\u53d1\u6025\u6027\u671f\u53cd\u5e94\u3002<\/p>\n

\u5927\u591a\u6570\u7ec6\u80de\u56e0\u5b50\u662f\u591a\u6548\u6027\u7684\uff0c\u5b83\u4eec\u5f71\u54cd\u8bb8\u591a\u4e0d\u540c\u7684\u7ec6\u80de\u3002\u8fd9\u610f\u5473\u7740\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u7684\u7ec6\u80de\u56e0\u5b50\u5f80\u5f80\u4f1a\u4ea7\u751f\u526f\u4f5c\u7528\u3002\u76ee\u524d\uff0c\u867d\u7136\u8bb8\u591a\u7ec6\u80de\u56e0\u5b50\u5df2\u7ecf\u751f\u4ea7\u51fa\u4e86\u9700\u8981\u7528\u4e8e\u6cbb\u7597\u7684\u6570\u91cf\uff0c\u4f46\u83b7\u5f97\u5e94\u7528\u8bb8\u53ef\u7684\u9002\u5e94\u75c7\u6570\u91cf\u975e\u5e38\u5c11\u3002\u8fd9\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u56e0\u4e3a\u8be5\u6cbb\u7597\u4f1a\u4ea7\u751f\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

BOX 24.2 <\/span>\u610f\u5916\u611f\u67d3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
\n

\u7537\u6027\uff0c51\u5c81\uff0c1\u5e74\u524d\u88ab\u8bca\u65ad\u4e3a\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3002\u8bca\u65ad\u8be6\u60c5\u89c1BOX 31.1<\/span>\u3002\u4ed6\u7684\u5173\u8282\u708e\u5bf9\u4e00\u7ebf\u836f\u7269\u6ca1\u6709\u53cd\u5e94\uff0c\u6240\u4ee5\u4ed6\u5f00\u59cb\u4f7f\u7528\u6297TNF\u7684\u5355\u514b\u9686\u6297\u4f53\u8fdb\u884c\u6cbb\u7597\u3002TNF\u5728\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u5173\u8282\u635f\u5bb3\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528(\u7b2c31\u7ae0<\/span>)\uff0c\u6297TNF\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\u975e\u5e38\u6709\u6548\u3002<\/p>\n

\u4f17\u6240\u5468\u77e5\uff0cTNF\u5355\u514b\u9686\u6297\u4f53\u53ef\u4ee5\u6fc0\u6d3b\u6f5c\u4f0f\u7684\u7ed3\u6838\u75c5\u3002\u8fd9\u662f\u56e0\u4e3aTNF\u5728\u7ef4\u6301\u8089\u82bd\u80bf\u5b8c\u6574\u6027\u7684\u7ec6\u80de\u56e0\u5b50\u7f51\u7edc\u4e2d\u975e\u5e38\u91cd\u8981(\u89c1Fig 23.2<\/span>)\u3002\u56e0\u6b64\uff0c\u5728\u5f00\u59cb\u6297TNF\u6cbb\u7597\u4e4b\u524d\uff0c\u5fc5\u987b\u6392\u9664\u6f5c\u4f0f\u6027\u7ed3\u6838\u75c5\u3002\u8fd9\u4f4d\u60a3\u8005\u8fdb\u884c\u4e86\u5e72\u6270\u7d20\u03b3\u91ca\u653e\u8bd5\u9a8c(IGRA\uff1bBOX 23.1<\/span>)\u3002\u8fd9\u4e2a\u6d4b\u8bd5\u662f\u9634\u6027\u7684\uff0c\u8fd9\u8868\u660e\u4f53\u5185\u6709\u6f5c\u4f0f\u7ed3\u6838\u75c5\u5730\u53ef\u80fd\u6027\u4e0d\u5927\u3002\u6392\u9664\u6f5c\u4f0f\u6027\u7ed3\u6838\u75c5\u540e\uff0c\u75c5\u4eba\u5f00\u59cb\u63a5\u53d7\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u6cbb\u7597\u3002<\/p>\n

\u60a3\u8005\u6bcf4\u5468\u9759\u8109\u6ce8\u5c04\u4e00\u6b21\u6297TNF\u6297\u4f53\u3002\u5728\u7b2c\u4e09\u6b21\u6ce8\u5c04\u540e\uff0c\u4ed6\u8bf4\u4ed6\u7684\u75c7\u72b6\u5927\u7ea6\u597d\u4e8675%\uff0c\u4ed6\u51b3\u5b9a\u7ee7\u7eed\u6cbb\u7597\u3002<\/p>\n

\u4e24\u5468\u540e\uff0c\u60a3\u8005\u51fa\u73b0\u9ad8\u70e7\u3001\u5934\u6655\u3001\u4f4e\u8840\u538b\u548c\u5fc3\u7387\u52a0\u5feb\u7684\u6025\u6027\u75be\u75c5\u3002\u6025\u8bca\u79d1\u533b\u751f\u8bca\u65ad\u4e3a\u611f\u67d3\u6027\u4f11\u514b\uff0c\u5728\u91c7\u96c6\u8840\u6db2\u57f9\u517b\u6837\u672c\u540e\uff0c\u60a3\u8005\u5f00\u59cb\u4f7f\u7528\u6297\u751f\u7d20\uff0c\u540e\u6765\u75c5\u4eba\u9010\u6e10\u5eb7\u590d\u3002\u4ece\u75c5\u4eba\u8840\u6db2\u57f9\u517b\u6837\u672c\u4e2d\u57f9\u517b\u51fa\u5355\u6838\u7ec6\u80de\u589e\u591a\u6027\u674e\u65af\u7279\u83cc\u3002<\/p>\n

\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u5355\u514b\u9686\u6297\u4f53\u9664\u4e86\u589e\u52a0\u91cd\u65b0\u6fc0\u6d3b\u7ed3\u6838\u75c5\u7684\u98ce\u9669\u5916\uff0c\u8fd8\u4f1a\u589e\u52a0\u5176\u4ed6\u7ec6\u80de\u5185\u751f\u7269\u4f53\u611f\u67d3\u7684\u98ce\u9669\u3002\u674e\u65af\u7279\u83cc\u5c31\u662f\u8fd9\u6837\u4e00\u79cd\u80de\u5185\u7ec6\u83cc\u3002\u8fd9\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u56e0\u98df\u7528\u53d7\u6c61\u67d3\u7684\u98df\u7269\u800c\u611f\u67d3\u7684\u75be\u75c5\uff0c\u7ea620%\u611f\u67d3\u674e\u65af\u7279\u83cc\u7684\u60a3\u8005\u6b7b\u4ea1\u3002\u8fd9\u4e2a\u6545\u4e8b\u8bf4\u660e\u4e86\u5728\u63a5\u53d7\u7ec6\u80de\u56e0\u5b50\u963b\u65ad\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u8003\u8651\u4e0d\u5bfb\u5e38\u611f\u67d3\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n
\u672c\u6587\u7531Oncolab\u5b9e\u9a8c\u5ba4\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaImmunology for Medical Students\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Immunology for Medical Students<\/span><\/section>\n
\u7ffb\u8bd1 |   \u674e\u6f84\u7199  \u5f90\u66fc\u65af \u848b\u4fca\u535a \u9648\u8389\u8679 <\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 |<\/span> \u90d1\u68a6\u6021<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u9648\u79cb\u8c37 \u5b8b\u4e50<\/span><\/section>\n
\u7ec8\u5ba1 | \u738b\u5764<\/span> \u8096\u5efa\u52c7<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

<\/section>\n

<\/section>\n

\u2589  \u5f80\u671f\u7cbe\u5f69\u5185\u5bb9\u63a8\u8350<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c23\u7ae0\uff1a\u708e\u75c7\u4e0e\u514d\u75ab<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c22\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u529f\u80fd<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c21\u7ae0\uff1a\u541e\u566c\u7ec6\u80de<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c20\u7ae0\uff1a\u56fa\u6709\u514d\u75ab\u7684\u9632\u5fa1\u4f5c\u7528<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c19\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u751f\u7406\u529f\u80fd\u7b80\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c17\u7ae0\uff1a\u514d\u75ab\u8bb0\u5fc6\u4e0e\u6dcb\u5df4\u7ec6\u80de\u7a33\u6001<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c16\u7ae0\uff1aT\u7ec6\u80de\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c15\u7ae0\uff1aT\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c14\u7ae0\uff1aB\u7ec6\u80de\u7684\u53d1\u80b2<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c13\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u5668\u5b98\u548c\u7ec4\u7ec7<\/span><\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c12\u7ae0\uff1a\u9020\u8840\u529f\u80fd-\u8840\u7ec6\u80de\u751f\u6210<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c5\u7ae0\uff1a\u6297\u4f53-\u6297\u539f\u76f8\u4e92\u4f5c\u7528<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c4\u7ae0\uff1a\u6297\u539f\u548c\u6297\u4f53\u7ed3\u6784<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c2\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u6982\u5ff5\u548c\u7ec4\u6210<\/a><\/span>
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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c3\u7ae0\uff1aCD8+ T\u7ec6\u80de\u5728\u514d\u75ab\u6cbb\u7597\u3001\u653e\u7597\u548c\u5316\u7597\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09<\/span><\/a>
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\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0b\uff09<\/span><\/a>
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\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c2\u7ae0\uff1a\u4eba\u7c7b\u80bf\u7624\u5fae\u73af\u5883\uff08\u4e0a\uff09<\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c1\u7ae0\uff1a\u80bf\u7624\u514d\u75ab\u7b80\u53f2<\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/strong><\/strong><\/p>\n

TCGA\u514d\u75ab\u6d78\u6da6\u8bc4\u4ef7\u6570\u636e\u5e93<\/a>
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ggplot2|\u8be6\u89e3\u516b\u5927\u57fa\u672c\u7ed8\u56fe\u8981\u7d20<\/a>
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Python\u96c6\u6210\u5f00\u53d1\u73af\u5883PyCharm\u7684\u5b89\u88c5\u4e0e\u6fc0\u6d3b<\/a>
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Python\u53d1\u884c\u7248Anaconda\u7684\u5b89\u88c5\u4e0e\u4f7f\u7528<\/a><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
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Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
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\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
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HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
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PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
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\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
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Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
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\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
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PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
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\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n

\u4e2d\u533b\u4e2d\u836f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u516b\u6bb5\u9526\uff08\u89c6\u9891\u7248+\u56fe\u7247\u7248\uff0c\u63a8\u8350\u6536\u85cf\uff09<\/span><\/a>
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\u4e2d\u6210\u836f\u4f20\u7edf\u65b9\u5242\u4ea4\u53c9\u68c0\u7d22\u6570\u636e\u5e93\u4f7f\u7528\u8bf4\u660e<\/span><\/a>
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\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n<\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5bfc \u8bfb \u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u548c\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u4e0d\u80fd\u5355\u72ec\u53d1\u6325\u4f5c\u7528\u3002\u514d\u75ab\u7ec6\u80de\u4f1a\u4f7f\u7528\u7ec6\u80de\u56e0\u5b50\u76f8\u4e92\u4ea4\u6d41\uff0c\u4ee5\u53ca\u4e0e\u4f53\u5185\u4e0d\u540c\u7ec4…<\/p>\n","protected":false},"author":1,"featured_media":1897,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[64],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1898"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=1898"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/1898\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/1897"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=1898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=1898"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=1898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}