{"id":2053,"date":"2020-04-28T00:00:00","date_gmt":"2020-04-27T16:00:00","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2020\/04\/28\/%e6%8a%97%e7%82%8e%e5%b0%8f%e5%88%86%e5%ad%90%e6%95%b0%e6%8d%ae%e5%ba%93%ef%bc%88aicd%ef%bc%89\/"},"modified":"2022-04-29T17:23:24","modified_gmt":"2022-04-29T09:23:24","slug":"%e6%8a%97%e7%82%8e%e5%b0%8f%e5%88%86%e5%ad%90%e6%95%b0%e6%8d%ae%e5%ba%93%ef%bc%88aicd%ef%bc%89","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2020\/04\/28\/%e6%8a%97%e7%82%8e%e5%b0%8f%e5%88%86%e5%ad%90%e6%95%b0%e6%8d%ae%e5%ba%93%ef%bc%88aicd%ef%bc%89\/","title":{"rendered":"\u6297\u708e\u5c0f\u5206\u5b50\u6570\u636e\u5e93\uff08AICD\uff09"},"content":{"rendered":"
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    \u708e\u75c7\u4e0e\u5404\u79cd\u75be\u75c5\u7684\u53d1\u751f\u548c\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u4f8b\u5982\u8fc7\u654f\u53cd\u5e94\uff0c\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff0c\u764c\u75c7\uff0c\u5173\u8282\u708e\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u8fd9\u4e9b\u75be\u75c5\u4e25\u91cd\u5a01\u80c1\u7740\u4eba\u7c7b\u5065\u5eb7\u3002\u7531\u4e8e\u5c0f\u5206\u5b50\u662f\u836f\u7269\u53d1\u73b0\u7684\u91cd\u8981\u6765\u6e90\uff0c\u56e0\u6b64\u6211\u4eec\u5f00\u53d1\u4e86\u6297\u708e\u5316\u5408\u7269\u6570\u636e\u5e93\uff08AICD\uff09\u6765\u4fc3\u8fdb\u6297\u708e\u836f\u7269\u7684\u53d1\u73b0\u3002AICD\u4e2d\u5305\u62ec79,781\u4e2a\u5c0f\u5206\u5b50\uff0c232\u4e2a\u4e0e\u708e\u75c7\u76f8\u5173\u7684\u9776\u6807\u4ee5\u53ca94,380\u6761\u5316\u5408\u7269-\u86cb\u767d\u8d28\u7ed3\u5408\u6d3b\u6027\u6570\u636e\u8bb0\u5f55\u3002\u5728AICD\u4e2d\uff0c\u6bcf\u4e2a\u5206\u5b50\u7684\u6d3b\u6027\u6570\u636e\u5747\u6765\u81ea\u5b9e\u9a8c\u6a21\u578bKi\uff0cIC50\uff0cEC50\u6216Kd\u3002180\u4e2a\u5b9e\u9a8c\u6a21\u578b\u5206\u4e3a16\u7c7b\uff0c\u4f8b\u5982\u7ade\u4e89\u6027\u6d3b\u6027\u6d4b\u5b9a\uff0c\u9176\u6d3b\u6027\u6d4b\u5b9a\u7b49\u3002\u6211\u4eec\u8fd8\u4e3aAICD\u4e2d\u4e0e\u708e\u75c7\u76f8\u5173\u7684\u9776\u6807\u63d0\u4f9b\u5728\u7ebf\u5206\u5b50\u5bf9\u63a5\u652f\u6301\u3002AICD\u6839\u636e\u77e5\u8bc6\u5171\u4eab\u7f72\u540d\u8bb8\u53ef\u534f\u8bae\u7684\u6761\u6b3e\u8fdb\u884c\u5206\u53d1\u548c\u590d\u5236\uff08Creative commons 4.0\uff09\u3002<\/span><\/p>\n

    Inflammation is closely related to the occurrence and development of various diseases, such as allergic reactions, atherosclerosis, cancer, arthritis and autoimmune diseases, which seriously threaten human health. The anti-inflamamtory compounds database (AICD) has been developed to facilitate the discovery of anti-inflammatory drugs since small molecules are an important source for drug discovery. AICD includes 79,781 small molecules, 232 inflammation-related targets, and 94,380 records of compound-protein binding activity data. In AICD, each molecule has activity data derived from experimental models, Ki, IC50, EC50 or Kd. 180 experimental models are grouped into 16 categories, such as competitive activity assay, enzyme activity assay, etc. We also provide online molecular docking support for inflammation-related targets in AICD. AICD is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.<\/span>
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How to cite this\uff1a<\/p>\n

Kun Wang#, Jianyong Xiao#, Xiaodong Liu#, Zhuqiao Jiang, Yujuan Zhan, Ting Yin, Lina He, Fangyuan Zhang, Shangping Xing, Bonan Chen, Yingshi Li, Fengxue Zhang, Zaoyuan Kuang*, Biaoyan Du*, Jiangyong Gu*. AICD: an integrated anti-inflammatory compounds database for drug discovery[J]. Scientific reports, 2019, 9(1): 1-10.<\/span><\/span><\/p>\n


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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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