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\u672c\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u9996\u5148\u7ed9\u5927\u5bb6\u4ecb\u7ecd\u4e00\u4e0b\u80bf\u7624\u53d1\u5c55\u53f2\uff0c\u80bf\u7624\u7ec6\u80de\u5982\u4f55\u5728\u708e\u6027\u7ec4\u7ec7\u4e2d\u751f\u957f\uff0c\u4ee5\u53ca\u708e\u6027\u7ec4\u7ec7\u5982\u4f55\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u5c55\u5e76\u53c2\u4e0e\u6740\u4f24\u3002\u968f\u540e\uff0c\u6211\u4eec\u5c06\u63cf\u8ff0\u80bf\u7624\u5fae\u73af\u5883\u7684\u529f\u80fd\uff0c\u4f4d\u7f6e\u4ee5\u53ca\u4eba\u7c7b\u80bf\u7624\u7ec4\u7ec7\u4e2d\u53d1\u73b0\u7684\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\uff0c\u6bd4\u8f83\u80bf\u7624\u5fae\u73af\u5883\u7684\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\u5bf9\u9884\u540e\u7684\u5f71\u54cd\uff0c\u5e76\u9610\u8ff0\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u7684\u4e00\u4e9b\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u957f\u671f\u4ee5\u6765\uff0c\u764c\u75c7\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u9057\u4f20\u6027\u548c\u7ec6\u80de\u6027\u75be\u75c5\uff0c\u73b0\u5728\u5219\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u7ec4\u7ec7\u7684\u548c\u5168\u8eab\u6027\u7684\u75be\u75c5\uff0c\u764c\u75c7\u7684\u53d1\u751f\u53d1\u5c55\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u4e0e\u5bbf\u4e3b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u53ef\u4ee5\u4fc3\u8fdb\u6216\u6291\u5236\u80bf\u7624\u7684\u4fb5\u88ad\u548c\u8f6c\u79fb\uff0c\u8fd9\u5728\u75be\u75c5\u8fc7\u7a0b\u7684\u4e0d\u540c\u9636\u6bb5\u4f1a\u53d1\u751f\u53d8\u5316\uff0c\u5bf9\u8fd9\u79cd\u52a8\u6001\u76f8\u4e92\u4f5c\u7528\u7684\u4e86\u89e3\u4f7f\u4eba\u4eec\u6709\u53ef\u80fd\u5728\u75be\u75c5\u7684\u5404\u4e2a\u9636\u6bb5\u627e\u5230\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u548c\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.2 \u764c\u75c7\u53d1\u5c55\u53f2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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40 \u591a\u5e74\u524d\uff0cPeter Nowell \u63d0\u51fa\u7531\u591a\u79cd\u8bf1\u53d8\u523a\u6fc0\u5f15\u8d77\u7684\u57fa\u56e0\u6539\u53d8\u53ef\u80fd\u662f\u6b63\u5e38\u7ec6\u80de\u5411\u80bf\u7624\u72b6\u6001\u8f6c\u53d8\u7684\u539f\u56e0 \u3002\u6839\u636e\u4ed6\u7684\u7406\u8bba\uff0c\u8fd9\u4e9b\u968f\u673a\u7a81\u53d8\u4f1a\u8d4b\u4e88\u7ec6\u80de\u81ea\u4e3b\u589e\u6b96\u80fd\u529b\u548c\u6c38\u751f\u80fd\u529b\u3002\u5982\u4eca\uff0c\u6211\u4eec\u77e5\u9053\u9057\u4f20\u7684\u4e0d\u7a33\u5b9a\u6027\u662f\u764c\u7ec6\u80de\u542f\u52a8\u7684\u6807\u5fd7\u4e8b\u4ef6\u3002\u4e8b\u5b9e\u4e0a\uff0c\u80bf\u7624\u7ec6\u80de\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u4f1a\u4ea7\u751f\u4e00\u7cfb\u5217\u7a81\u53d8\uff0c\u4eba\u4eec\u8ba4\u4e3a\u9057\u4f20\u5f02\u5e38\u7684\u9010\u6b65\u79ef\u7d2f\u6700\u7ec8\u4f1a\u5bfc\u81f4\u5b83\u4eec\u7684\u6076\u53d8\u3002\u5e73\u5747\u800c\u8a00\uff0c\u4e00\u4e2a\u80bf\u7624\u7ec6\u80de\u4e00\u822c\u8868\u73b0\u51fa 120 \u4e2a\u975e\u540c\u4e49\u7a81\u53d8<\/span> <\/span>\uff0c\u8fd9\u4e9b\u7a81\u53d8\u4e0d\u4ec5\u8d4b\u4e88\u5b83\u4eec\u81ea\u4e3b\u53ca\u4e0d\u53d7\u63a7\u5236\u7684\u589e\u6b96\u80fd\u529b\uff0c\u800c\u4e14\u8fd8\u8d4b\u4e88\u5b83\u4eec\u4e00\u4e9b\u5176\u4ed6\u7279\u5f81\uff0c\u4f7f\u5b83\u4eec\u80fd\u591f\u5728\u6076\u52a3\u7684\u4eba\u4f53\u73af\u5883\u4e2d\u751f\u5b58\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2011\u5e74\uff0cHanahan\u548cWeinberg\u53d1\u73b0\u4e86\u764c\u7ec6\u80de\u7684\u4e3b\u8981\u6807\u5fd7\u53ca\u57fa\u672c\u7279\u5f81\uff0c\u8fd9\u4e9b\u7279\u5f81\u89e3\u91ca\u4e86\u80bf\u7624\u7ec6\u80de\u4e4b\u6240\u4ee5\u53ef\u4ee5\u53d1\u5c55\u4e3a\u4e00\u4e2a\u7624\u5757\u7684\u539f\u56e0\u3002\u867d\u7136\u57fa\u56e0\u4e0d\u7a33\u5b9a\u6027\u548c\u589e\u6b96\u80fd\u529b\u7684\u589e\u52a0\u4ecd\u7136\u662f\u80bf\u7624\u53d1\u5c55\u7684\u91cd\u8981\u539f\u56e0\uff0c\u4f46\u76ee\u524d\u4eba\u4eec\u5df2\u7ecf\u8ba4\u8bc6\u5230\u80bf\u7624\u7ec6\u80de\u4e5f\u9700\u8981\u4e0e\u5468\u56f4\u7684\u5185\u76ae\u7ec6\u80de\u3001\u95f4\u8d28\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u79ef\u6781\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u4fdd\u8bc1\u81ea\u8eab\u7684\u5b58\u6d3b\u3002\u56e0\u6b64\uff0c\u80bf\u7624\u7ec6\u80de\u901a\u5e38\u4f1a\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u548c\u708e\u75c7\uff0c\u5f62\u6210\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u673a\u5236\u3002\u867d\u7136\u8fd9\u4e9b\u4fc3\u80bf\u7624\u529f\u80fd\u7684\u83b7\u5f97\u662f\u65b0\u7684\u7a81\u53d8\u7684\u7ed3\u679c\uff0c\u4f46\u662f\u771f\u6b63\u4f7f\u7ec6\u80de\u6076\u6027\u7a0b\u5ea6\u66f4\u9ad8\u4fb5\u88ad\u80fd\u529b\u66f4\u5f3a\u7684\u539f\u56e0\u662f\u6076\u52a3\u73af\u5883\u6240\u4ecb\u5bfc\u7684\u7b5b\u9009\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u548c\u53d1\u5c55\u7684\u57fa\u77f3\u662f\u57fa\u56e0\u7a81\u53d8\uff0c\u57fa\u56e0\u7a81\u53d8\u53ef\u4ee5\u7531\u591a\u79cd\u56e0\u7d20\u8bf1\u5bfc\uff08Fig <\/span>2.1<\/span>\uff09\u3002\u6211\u4eec\u5728\u751f\u6d3b\u4e2d\u4f1a\u4e0d\u65ad\u5730\u66b4\u9732\u4e8e\u8bf1\u53d8\u5242\uff0c\u5982\u7d2b\u5916\u7ebf\uff0c\u6c61\u67d3\u751a\u81f3\u75c5\u6bd2\u73af\u5883\u4e2d\u3002\u6b63\u5e38\u7ec6\u80de\u901a\u5e38\u62e5\u6709\u6709\u6548\u7684\u673a\u5236\u6765\u4fee\u590d\u7a81\u53d8\u7684DNA\uff0c\u6216\u8005\u5f53\u635f\u4f24\u65e0\u6cd5\u4fee\u590d\u65f6\uff0c\u7ec6\u80de\u5185\u7684\u7ea7\u8054\u53cd\u5e94\u4f1a\u4fc3\u8fdb\u7ec6\u80de\u6b7b\u4ea1\u3002\u4e00\u4e9b\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5982\u7740\u8272\u6027\u5e72\u76ae\u75c5\uff08\u7531\u4e8eDNA\u4fee\u590d\u673a\u5236\u7684\u7f3a\u9677\uff0c\u5728\u65e9\u5e74\u60a3\u76ae\u80a4\u764c\u7684\u98ce\u9669\u6781\u9ad8\uff09\u63d0\u793a\u4e86\u4fee\u590d\u7cfb\u7edf\u5728\u9884\u9632\u764c\u75c7\u53d1\u5c55\u4e2d\u7684\u91cd\u8981\u6027\u4ee5\u53ca\u6211\u4eec\u66b4\u9732\u4e8e\u8bf1\u53d8\u523a\u6fc0\u4e0b\u7684\u9891\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 2.1<\/span> \u5728\u764c\u53d8\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u4e3b\u8981\u514d\u75ab\u548c\u9057\u4f20\u4e8b\u4ef6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u708e\u75c7\u4ecb\u8d28\u4e5f\u662f\u4f17\u6240\u5468\u77e5\u7684\u57fa\u56e0\u6539\u53d8\u7684\u4fc3\u8fdb\u5242\u3002\u4e8b\u5b9e\u4e0a\uff0c\u708e\u6027\u514d\u75ab\u7ec6\u80de(\u5982\u5de8\u566c\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de)\u4ea7\u751f\u7684\u8bb8\u591a\u7269\u8d28\u90fd\u53ef\u4ee5\u76f4\u63a5\u635f\u4f24\u975e\u514d\u75ab\u7ec6\u80de\u4e2d\u7684DNA\u3002\u5728\u6709\u5bb3\u523a\u6fc0\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u6162\u6027\u708e\u75c7\u65e2\u53ef\u4ee5\u8bf1\u5bfc\u81f4\u7624\u57fa\u56e0\u7a81\u53d8\uff0c\u53c8\u53ef\u4ee5\u4fc3\u8fdb\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\uff0c\u4ece\u800c\u4fc3\u4f7f\u8fdb\u4e00\u6b65\u53d8\u5316\u7684\u53d1\u751f\u3002\u8fd9\u79cd\u7531\u6162\u6027\u708e\u75c7\u5f15\u8d77\u7684\u764c\u75c7\u8fc7\u7a0b\uff08Fig<\/span> 2.1<\/span>\uff09\u5df2\u7ecf\u5728\u51e0\u79cd\u75c5\u7406\u673a\u5236\u4e2d\u88ab\u63cf\u8ff0\uff0c\u5305\u62ec\u4e0e\u5e7d\u95e8\u87ba\u6746\u83cc\u611f\u67d3\u76f8\u5173\u7684\u80c3\u764c\u3001\u77f3\u68c9\u6216\u9999\u70df\u70df\u96fe\u66b4\u9732\u5f15\u8d77\u7684\u80ba\u764c\u3001\u7837\u66b4\u9732\u5f15\u8d77\u7684\u76ae\u80a4\u764c\u3001\u80c3\u98df\u7ba1\u53cd\u6d41\u5bfc\u81f4\u7684\u98df\u9053\u764c\u3001\u708e\u75c7\u6027\u80a0\u9053\u75be\u75c5\u5f15\u8d77\u7684\u7ed3\u76f4\u80a0\u764c\u3001\u6162\u6027\u80f0\u817a\u708e\u4e0e\u80f0\u817a\u764c\u4ee5\u53ca\u76c6\u8154\u708e\u4e0e\u5375\u5de2\u764c\u7684\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u708e\u6027\u81f4\u764c\u4ecb\u8d28\u5305\u62ec\u6d3b\u6027\u6c27\u548c\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff0c\u5b83\u4eec\u5206\u522b\u53ef\u4ee5\u5f15\u8d77DNA\u635f\u4f24\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u7834\u574f\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u7ec6\u80de\u56e0\u5b50\u53ef\u4ee5\u8bf1\u5bfc\u5f02\u5e38\u7ec6\u80de\u6216\u764c\u524d\u7ec6\u80de\u7684\u751f\u957f\uff0c\u5982\u80c3\u764c\u76f8\u5173\u7684IL-1\u03b2\u548c\u9ed1\u8272\u7d20\u7624\u76f8\u5173\u7684IL-8\u3002\u8bb8\u591a\u5176\u4ed6\u7ec6\u80de\u56e0\u5b50(\u5982IL-1\u03b2\u3001IL-6\u3001IL-23\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1)\u7684\u4fc3\u7624\u6f5c\u80fd\u4e5f\u5df2\u6709\u76f8\u5173\u62a5\u9053\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u75c5\u6bd2\u76f8\u5173\u7684\u764c\u75c7\u4e2d\uff0c\u9664\u4e86\u611f\u67d3\u672c\u8eab\u5f15\u8d77\u7684\u708e\u75c7\u5916\uff0c\u75c5\u6bd2\u9057\u4f20\u7269\u8d28\u8fd8\u53ef\u4ee5\u6574\u5408\u5230\u5bbf\u4e3b\u57fa\u56e0\u7ec4\u4e2d\uff0c\u901a\u8fc7\u6539\u53d8\u4e0d\u540c\u7684\u81f4\u764c\u9014\u5f84\u8bf1\u5bfc\u7ec6\u80de\u8f6c\u5316\u3002\u75c5\u6bd2\u76f8\u5173\u6027\u764c\u75c7\u7ea6\u5360\u6240\u6709\u764c\u75c7\u7c7b\u578b\u768420%\uff0c\u5305\u62ec\u5bab\u9888\u764c\uff08HPV\u8bf1\u5bfc\uff09\uff0cB\u7ec6\u80de\u6dcb\u5df4\u7624\uff08EBV\u8bf1\u5bfc\uff09\uff0cMerkel\u7ec6\u80de\u764c\uff08Merkel  CelloMavirus\u8bf1\u5bfc\uff09\uff0c\u809d\u7ec6\u80de\u764c\uff08\u7531\u4e59\u578b\u809d\u708e\u548cC\u75c5\u6bd2\u5f15\u8d77\uff09\uff0c\u4ee5\u53ca\u4e00\u4e9b\u80c3\u764c\u548c\u5934\u9888\u90e8\u764c\u75c7\uff08EBV\u8bf1\u5bfc\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.3  \u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5982\u4e0a\u6240\u8ff0\uff0c\u80bf\u7624\u5fae\u73af\u5883\u662f\u4e00\u79cd\u975e\u5e38\u590d\u6742\u4e14\u52a8\u6001\u7684\u751f\u6001\u7cfb\u7edf\uff0c\u662f\u6709\u5f88\u591a\u4e0d\u540c\u7ec6\u80de\u7fa4\u5171\u5b58\u7684\u5730\u65b9\u3002\u4e3b\u8981\u53c2\u4e0e\u8005\u5305\u62ec\u80bf\u7624\u7ec6\u80de\u3001\u514d\u75ab\u7ec6\u80de\u548c\u652f\u6301\u7ec6\u80de<\/span>\uff08\u4f8b\u5982\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u57fa\u8d28\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u6216\u708e\u75c7\u7ec6\u80de\u4ea7\u751f\u7684\u8d8b\u5316\u56e0\u5b50\u7684\u5438\u5f15\u4f5c\u7528\u4e0b\uff0c\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u901a\u8fc7\u8de8\u5185\u76ae\u8fc7\u7a0b\u8fc1\u79fb\u81f3\u80bf\u7624\u90e8\u4f4d\u3002\u5728\u80bf\u7624\u7ec4\u7ec7\u5185\uff0c\u514d\u75ab\u7ec6\u80de\u5c40\u90e8\u589e\u6b96\u3001\u5206\u5316\u3001\u53d1\u6325\u529f\u80fd\u3001\u6b7b\u4ea1\uff0c\u90e8\u5206\u8fc1\u79fb\u56de\u5faa\u73af\u7cfb\u7edf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fd9\u4e9b\u7ec6\u80de\u7fa4\u4e2d\uff0c\u4eba\u4eec\u7ecf\u5e38\u53ef\u4ee5\u627e\u5230\u4e0e\u6025\u6027\u708e\u75c7\u76f8\u5173\u7684\u7ec6\u80de\uff08\u5305\u62ec\u4e2d\u6027\u7c92\u7ec6\u80de\u3001\u55dc\u78b1\u6027\u7c92\u7ec6\u80de\u548c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\uff09\u3001\u5148\u5929\u514d\u75ab\u76f8\u5173\u7684\u7ec6\u80de\uff08\u5305\u62ec\u5de8\u566c\u7ec6\u80de\u3001NK \u7ec6\u80de\u548c DC\uff09\u4ee5\u53ca\u6765\u81ea\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u7ec6\u80de\uff08\u5305\u62ecCD8+ <\/sup>T \u7ec6\u80de\u3001Th1-\/Th2\u7ec6\u80de\u548c B \u7ec6\u80de\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.3.1 \u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de (TAM) \u662f\u4e00\u4e2a\u6570\u91cf\u76f8\u5bf9\u4e30\u5bcc\u7684\u7ec6\u80de\u4e9a\u7fa4\uff0c\u5728\u8bb8\u591a\u80bf\u7624\u4e2d\uff0c\u5b83\u4eec\u7684\u6570\u91cf\u662f\u8d85\u8fc7\u5176\u4ed6\u7c7b\u578b\u514d\u75ab\u7ec6\u80de\u7684\u3002\u867d\u7136\u5927\u591a\u6570TAM\u4f4d\u4e8e\u80bf\u7624\u7684\u8fb9\u7f18\u90e8\u4f4d\uff0c\u4f46\u6211\u4eec\u4e5f\u53ef\u4ee5\u5728\u80bf\u7624\u6838\u5fc3\u5904\u53d1\u73b0\u5176\u5bc6\u5ea6\u7684\u589e\u9ad8\u3002TAM\u5177\u6709\u9ad8\u5ea6\u53ef\u5851\u6027\u7684\u8868\u578b\u548c\u529f\u80fd\uff0c\u76ee\u524d\u5df2\u7ecf\u786e\u5b9a\u7684\u6709\u4e24\u79cd\u4e3b\u8981\u4e9a\u578b\uff1aM1\u578bTAM(\u7531Toll\u6837\u53d7\u4f53\u914d\u4f53[\u5982\u8102\u591a\u7cd6\u548c\u5e72\u6270\u7d20-\u03b3]\u8bf1\u5bfc)\uff0c\u4f18\u5148\u8868\u8fbe\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176\uff1bM2\u578bTAM(\u7531IL-4\u6216IL-13\u8bf1\u5bfc)\uff0c\u8868\u8fbe\u7cbe\u6c28\u9178\u91761\u3001CD206\u3001CD163\u3001IL-4R\u3001TGF-\u03b21\u548c\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50(PDGF)\u3002\u4e00\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cM1\u578bTAM\u53ef\u589e\u5f3a\u6297\u80bf\u7624 Th1 \u53cd\u5e94\u5e76\u62ee\u6297\u8c03\u8282\u6027\u514d\u75ab\u7ec6\u80de\u7684\u6291\u5236\u6d3b\u6027\uff0c\u800cM2\u578bTAM\u5219\u4e3b\u8981\u53d1\u6325\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3001\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb\u7684\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.3.2  NK\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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NK\u7ec6\u80de\u662f\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u7ec6\u80de\u6bd2\u6027\u6548\u5e94\u6dcb\u5df4\u7ec6\u80de\uff0c\u5176\u4e3b\u8981\u529f\u80fd\u662f\u5e2e\u52a9\u63a7\u5236\u611f\u67d3\u548c\u80bf\u7624\u3002NK\u7ec6\u80de\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u7684\u4e24\u4e2a\u4e3b\u8981\u673a\u5236\u662f\uff1a\u5b83\u4eec\u53ef\u4ee5\u8bc6\u522bMHC-I\u7c7b\u5206\u5b50\u8868\u8fbe\u4e0b\u8c03\u7684\u7ec6\u80de\uff08\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5747\u8868\u73b0\u51fa\u7684\u4e00\u79cd\u514d\u75ab\u8010\u53d7\u73b0\u8c61\uff09\uff0c\u6216\u4e0e\u80bf\u7624\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u5e94\u6fc0\u8bf1\u5bfc\u914d\u4f53\u7ed3\u5408(\u5982MICA\u6216MICB\uff0c\u5b83\u4eec\u53ef\u4e0eNK\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684NKG2D\u7ed3\u5408)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.3.3 \u6811\u7a81\u72b6\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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\u6811\u7a81\u72b6\u7ec6\u80de (DC) \u7684\u4e3b\u8981\u529f\u80fd\u662f\u5728\u5148\u5929\u6027\u548c\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u4e4b\u95f4\u8d77\u5230\u6865\u6881\u4f5c\u7528\u3002\u5728\u751f\u7406\u73af\u5883\u4e0b\uff0cDC \u541e\u566c\u5e76\u5904\u7406\u975e\u81ea\u8eab\u6297\u539f\uff0c\u5f53\u5b83\u4eec\u63a5\u6536\u5230\u5371\u9669\u6216\u6fc0\u6d3b\u4fe1\u53f7\u65f6\uff0c\u4f1a\u88ab\u6fc0\u6d3b\u5e76\u79fb\u52a8\u5230\u6dcb\u5df4\u7ed3\u7684\u6b21\u7ea7\u6dcb\u5df4\u7ed3\u6784\uff0c\u5728\u90a3\u91cc\u6fc0\u6d3b<\/span>\u521d\u59cb B \u6216 T \u7ec6\u80de\u3002DC \u7684\u8868\u578b\u5177\u6709\u76f8\u5f53\u7684\u53ef\u5851\u6027\uff0c\u5b83\u4eec\u53ef\u4ee5\u4ea7\u751f\u591a\u79cd\u7684\u4fc3\u708e\u6216\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\uff0c\u4ee5\u53ca\u8868\u8fbe\u4e00\u7cfb\u5217\u7684\u6fc0\u6d3b\u6216\u6291\u5236\u6027\u7684\u53d7\u4f53\uff0c\u8fd9\u53d6\u51b3\u4e8e\u5b83\u4eec\u6240\u5728\u7684\u73af\u5883\u3002\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u662f\u53d7\u4fdd\u62a4\u7684\u73af\u5883\uff0c\u5728\u6b64\u73af\u5883\u4e2d\u53ef\u4ea7\u751f\u80fd\u591f\u6709\u6548\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684 DC \u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8bb8\u591a\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\u53ef\u4ea7\u751f\u8bf1\u5bfcDC\u5411\u708e\u6027DC\u6216\u8010\u53d7\u6027DC\u5206\u5316\u7684\u5206\u5b50\uff0c\u5e76\u53ef\u5728\u4e0d\u540c\u9636\u6bb5\u963b\u65adDC\u7684\u6210\u719f\u3002\u901a\u5e38\uff0c\u80bf\u7624\u5185\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u8868\u73b0\u51fa\u4e0d\u6210\u719f\u548c\u6291\u5236\u6027\u7684\u8868\u578b\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd1\u5e74\u6765\uff0c\u6709\u51e0\u9879\u5de5\u4f5c\u63cf\u8ff0\u4e86\u5728\u8bb8\u591a\u764c\u75c7\u7684\u4fb5\u88ad\u6027\u8fb9\u7f18\u4e2d\u5b58\u5728\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u6784 (TLS) \uff0c\u7406\u8bba\u4e0a \u5728\u8fd9\u4e2a\u533a\u57dfDCs \u662f\u53d7\u5230\u4fdd\u62a4\u7684\uff0c\u53ef\u514d\u53d7\u80bf\u7624\u4ea7\u751f\u7684\u6291\u5236\u6027\u7269\u8d28\u7684\u5f71\u54cd\uff0c\u5e76\u4e14\u5728\u8fd9\u91cc\u53ef\u4ee5\u6709\u6548\u5730\u5f15\u53d1\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.3.4  \u4e09\u7ea7\u6dcb\u5df4\u7ed3\u7ed3\u6784<\/strong><\/p>\n<\/section>\n

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TLS\u662f\u5728\u708e\u75c7\u75c5\u7406\u72b6\u6001\u4e0b\u53d1\u5c55\u8d77\u6765\u7684\u9ad8\u5ea6\u7ec4\u7ec7\u5316\u7684\u6dcb\u5df4\u96c6\u5408\u4f53\u3002\u5728\u764c\u75c7\u4e2d\uff0cTLS\u901a\u5e38\u53d1\u751f\u5728\u80bf\u7624\u7684\u6d78\u6da6\u8fb9\u7f18\u548c\/\u6216\u95f4\u8d28\u4e2d\uff0c\u7c7b\u4f3c\u4e8e\u5176\u4ed6\u6162\u6027\u611f\u67d3\u6027\u6216\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002Fig 2.2A<\/span> \u5c55\u793a\u4e86\u5728\u900f\u660e\u7ec6\u80de\u80be\u7ec6\u80de\u764c (ccRCC) \u4e2d\u53d1\u73b0\u7684 TLS\u3002\u5178\u578b\u5730\uff0cTLS \u8868\u73b0\u51fa\u7c7b\u4f3c\u4e8e\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u7684\u7ec4\u7ec7\u7ed3\u6784\uff0c\u5305\u62ec T \u7ec6\u80de\u533a\uff08Fig 2.2Aa<\/span>\uff09\u548c B \u7ec6\u80de\u6ee4\u6ce1\u533a\uff08Fig 2.2Ab<\/span>\uff09\uff0c\u5e76\u4e14\u901a\u5e38\u88ab\u9ad8\u5185\u76ae\u5fae\u9759\u8109\u5305\u56f4\u3002B\u7ec6\u80de\u5728TLS\u4e2d\u5f62\u6210\u751f\u53d1\u4e2d\u5fc3\uff1b\u5b83\u4eec\u5177\u6709\u6d3b\u8dc3\u7684\u589e\u6b96\u673a\u5236\u548c\u4f53\u7ec6\u80de\u9ad8\u7a81\u53d8\u3002T \u7ec6\u80de\u5177\u6709 CD62L+<\/sup>\/CD45RO+<\/sup> \u4e2d\u592e\u8bb0\u5fc6\u6216\u5e7c\u7a1a\u8868\u578b\uff0c\u6709\u4e9b\u53ef\u4e0e\u8868\u8fbe DC-Lamp \u6807\u5fd7\u7269\u7684\u6210\u719f DC \u63a5\u89e6\uff08Fig 2.2Aa<\/span>\uff09\u6216\u5728 B \u7ec6\u80de\u6ee4\u6ce1\u7684\u5916\u56f4\u5b58\u5728\uff08Fig 2.2Ac\uff09<\/span><\/span>\u3002\u8fd8\u68c0\u6d4b\u5230\u6ee4\u6ce1\u6811\u7a81\u7ec6\u80de\u5f62\u6210\u7f51\u7edc\uff0c\u5728\u8be5\u7f51\u7edc\u4e2d\u53ef\u4ee5\u5f62\u6210\u514d\u75ab\u590d\u5408\u7269\u5e76\u5448\u9012\u7ed9\u9ad8\u4eb2\u548c\u529b B \u7ec6\u80de\u3002\u4ea7\u751f\u6297\u4f53\u7684\u6d46\u7ec6\u80de\u4f4d\u4e8e TLS \u9644\u8fd1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 2.2<\/span> \u77f3\u8721\u5207\u7247\u514d\u75ab\u7ec4\u5316\u68c0\u6d4b\u4eba\u80be\u900f\u660e\u7ec6\u80de\u764c\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002(A)\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u6784\uff1a(a)CD3+T\u7ec6\u80de\u533a(\u84dd\u8272)\u4e2d\u7684DC-Lamp+\u6210\u719fDC(\u68d5\u8272)\uff1b(b)CD20+B\u7ec6\u80de(\u68d5\u8272)\u548cCD21+\u6ee4\u6ce1\u6811\u7a81\u72b6\u7ec6\u80de(\u84dd\u8272)\u63cf\u7ed8\u51fa\u751f\u53d1\u4e2d\u5fc3\uff1b(c)CD8+T\u7ec6\u80de(\u68d5\u8272)\u5206\u5e03\u5728\u751f\u53d1\u4e2d\u5fc3\u5468\u56f4\uff1b(d)\u975eTLS-DC-Lamp+DC(\u68d5\u8272)\u3002(B)CD8+T\u7ec6\u80de(\u68d5\u8272)(\u5de65\u00d7\uff0c\u53f320\u00d7)\u3002(C)CD163+\u5de8\u566c\u7ec6\u80de(\u7ea2\u8272)(\u5de65\u00d7\uff0c\u53f320\u00d7)\uff0cTum=\u80bf\u7624\u533a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u539f\u53d1\u6027\u80bf\u7624\u548c\u8f6c\u79fb\u7624\u542b\u6709\u4e0d\u540c\u5bc6\u5ea6\u7684 TLS\uff0c\u5177\u4f53\u53d6\u51b3\u4e8e\u80bf\u7624\u7c7b\u578b\u548c\u60a3\u8005\u3002\u5982\u4e0b\u6240\u8ff0\uff0c\u5047\u8bbe TLS \u53cd\u6620\u4e86\u80bf\u7624\u5185\u6b63\u5728\u8fdb\u884c\u7684\u514d\u75ab\u53cd\u5e94\u3002\u5b83\u4eec\u5141\u8bb8\u6210\u719f\u6811\u7a81\u7ec6\u80de\u5c06\u80bf\u7624\u6297\u539f\u5448\u9012\u7ed9 T \u7ec6\u80de\uff0c\u4ece\u800c\u5bfc\u81f4 CD4+ Th1 \u7ec6\u80de\u7684\u5206\u5316\uff0c\u8fd9\u79cd\u5206\u5316\u53cd\u6620\u5728 T-bet \u7684\u8868\u8fbe\u548c  T-B \u7ec6\u80de\u7684\u534f\u540c\u4f5c\u7528\u5728B \u7ec6\u80de\u5206\u5316\u4e3a\u6d46\u7ec6\u80de\u7684\u7684\u8fc7\u7a0b\u4e2d\u6240\u53d1\u6325\u7684\u529f\u80fd\uff0c\u6240\u6709\u8fd9\u4e9b\u4e8b\u4ef6\u90fd\u53ef\u4ee5\u5728\u80bf\u7624\u5c40\u90e8\u53d1\u751f\u3002TLS \u5728\u591a\u5927\u7a0b\u5ea6\u4e0a\u7ed5\u8fc7\u4e86\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u6765\u542f\u52a8\u6216\u63a7\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4ecd\u7136\u662f\u4e00\u4e2a\u60ac\u800c\u672a\u51b3\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.3.5  CD4 +<\/sup>T\u548cCD8 +<\/sup>T\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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CD4+ <\/sup>T \u8f85\u52a9\u7ec6\u80de\u5206\u4e3a\u4e0d\u540c\u7684\u4e9a\u578b\uff0c\u5305\u62ec Th1\u3001Th2\u3001Th17\u3001Tfh \u548c Treg\uff1b\u6bcf\u4e2a\u4e9a\u7fa4\u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u90fd\u53d1\u6325\u7740\u7279\u5b9a\u7684\u4f5c\u7528\u3002\u603b\u4f53\u800c\u8a00\uff0c\u4ee5 Th1 \u4e3a\u5bfc\u5411\u7684\u53cd\u5e94\u4f1a\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5e76\u4e14\u901a\u5e38\u4e0e\u826f\u597d\u7684\u4e34\u5e8a\u7ed3\u679c\u76f8\u5173\u3002\u4e8b\u5b9e\u4e0a\uff0cTh1\u7ec6\u80de\u53ef\u901a\u8fc7\u4ea7\u751f\u5305\u62ec IL-2 \u548c IFN-\u03b3 \u5728\u5185\u7684\u51e0\u79cd\u7ec6\u80de\u56e0\u5b50\uff0c\u5728\u539f\u4f4d\u589e\u5f3a\u7ec6\u80de\u6bd2\u6027 T \u7ec6\u80de\u7684\u6297\u80bf\u7624\u529f\u80fd\u3002Tfh\u7ec6\u80de\u4e0e TLS \u4e2d\u7684 B \u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u4ee5\u5e2e\u52a9\u4ea7\u751f\u6297\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5176\u4ed6\u80bf\u7624\u6d78\u6da6CD4+ <\/sup>T\u7ec6\u80de\u4e9a\u7fa4(Th2\u3001Th17\u548cTreg)\u7684\u4f5c\u7528\u5c1a\u4e0d\u662f\u5f88\u6e05\u695a\uff0c\u4f46\u5728\u4e0d\u540c\u7684\u80bf\u7624\u4e2d\u5e38\u4e0e\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u8bb8\u591a\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u4e2d\u7684Treg\u901a\u8fc7\u4e24\u79cd\u4e3b\u8981\u673a\u5236\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94:<\/p>\n

(1)\u4ea7\u751f\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50(\u5982IL-10\u3001TGF-\u03b2\u3001IL-35)\uff1b<\/p>\n

(2)\u6291\u5236DC\u7684\u53d1\u80b2\u6210\u719f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CD8+<\/sup> T \u7ec6\u80de\u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u53d1\u6325\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u56e0\u4e3a\u5b83\u4eec\u8d1f\u8d23\u8bc6\u522b\u548c\u6d88\u9664\u80bf\u7624\u7ec6\u80de\u3002\u7531\u4e8e\u57fa\u56e0\u7ec4\u7684\u4e0d\u7a33\u5b9a\u6027\uff0c\u80bf\u7624\u7ec6\u80de\u901a\u5e38\u5728\u5176\u8868\u9762\u8868\u8fbe\u7a81\u53d8\u86cb\u767d\u3002\u5176\u4e2d\u8bb8\u591a\u662f\u8bf1\u5bfc\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u7684\u65b0\u6297\u539f\u3002\u6d3b\u5316\u7684 CD8+ <\/sup>T \u7ec6\u80de\u8d1f\u8d23\u80bf\u7624\u7ec6\u80de\u7684\u8bc6\u522b\u548c\u88c2\u89e3\uff0c\u5176\u673a\u5236\u5728\u6587\u732e\u4e2d\u6709\u8be6\u7ec6\u63cf\u8ff0\uff0c\u5176\u4e2d\u5305\u62ec\u91ca\u653e\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u5927\u591a\u6570\u80bf\u7624\u4e2d\uff0c\u6d78\u6da6\u6027\u7ec6\u80de\u6bd2\u6027 T \u7ec6\u80de\u8868\u8fbe\u6291\u5236\u6027\u53d7\u4f53\uff08\u4f8b\u5982 PD-1\u3001Tim-3 \u548c Lag-3\uff09\uff0c\u5176\u5728\u751f\u7406\u60c5\u51b5\u4e0b\u7684\u529f\u80fd\u662f\u4e0e\u5176\u914d\u4f53\u7ed3\u5408\u65f6\u6291\u5236<\/span><\/span>\u514d\u75ab\u53cd\u5e94\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8bb8\u591a\u80bf\u7624\u7ec6\u80de\u53ef\u4ee5\u5229\u7528\u8fd9\u79cd\u6291\u5236\u673a\u5236\uff0c\u5e76\u8868\u8fbe\u591a\u79cd\u914d\u4f53\uff08\u4f8b\u5982 PD-L1\u3001PD-L2\uff09\uff0c\u5e2e\u52a9\u5b83\u4eec\u9003\u907f T \u7ec6\u80de\u7684\u653b\u51fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

2.3.6 B\u6dcb\u5df4\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

\n
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\n

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\n

2.3.7 \u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u7684\u65f6\u7a7a\u52a8\u6001<\/strong><\/p>\n<\/section>\n

\n
\n
\n

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\n
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\u8fd9\u4e9b\u8fc7\u7a0b\u7684\u4e00\u4e2a\u76f4\u63a5\u7ed3\u679c\u662f\uff0c\u80bf\u7624\u5fae\u73af\u5883\u662f\u4e00\u79cd\u7ec4\u7ec7\u4f9d\u8d56\u6027\u7684\u7ed3\u6784\uff0c\u5176\u4e2d\u514d\u75ab\u7ec6\u80de\u662f\u5171\u540c\u7684\u7ec4\u6210\u90e8\u5206\u3002<\/p>\n

Fig 2.2B<\/span> \u8bf4\u660e\u4e86\u5728\u900f\u660e\u7ec6\u80de\u80be\u7ec6\u80de\u764c\u7684\u80bf\u7624\u533a\u4e2d\u5b58\u5728 CD8+ <\/sup>T \u7ec6\u80de\u3002\u4ed4\u7ec6\u89c2\u5bdf\u514d\u75ab\u5fae\u73af\u5883\u7684\u7ec4\u7ec7\u7ed3\u6784\u53d1\u73b0\uff0c\u7ec6\u80de\u5728\u80bf\u7624\u533a\u57df\u7684\u5206\u5e03\u5e76\u4e0d\u5747\u5300\u3002\u6dcb\u5df4\u7ec6\u80de\uff08T \u548c B \u7ec6\u80de\uff09\u5728\u6d78\u6da6\u8fb9\u7f18\u7684\u7ec4\u7ec7\u8fb9\u754c\u533a\u57df\u4e2d\u6bd4\u5728\u80bf\u7624\u4e2d\u5fc3\u66f4\u4e30\u5bcc\u3002\u5b83\u4eec\u53ef\u4ee5\u5206\u6563\u6216\u805a\u96c6\u5728\u805a\u96c6\u4f53\u4e2d\uff0c\u5728\u6d78\u6da6\u6027\u8fb9\u7f18\u548c\/\u6216\u57fa\u8d28\u4e2d\u5f62\u6210 TLS \u3002\u5927\u591a\u6570 T \u548c B \u7ec6\u80de\u5177\u6709\u8bb0\u5fc6\u8868\u578b\uff0cCD8+<\/sup> T\u3001CD4+<\/sup> Treg\u3001Th1\u3001Th2\u3001Th17 \u548c B \u7ec6\u80de\u4ee5\u4e0d\u540c\u7684\u5bc6\u5ea6\u88ab\u68c0\u6d4b\u5230\uff0c\u800c\u5e7c\u7a1a T \u7ec6\u80de\u548c CD4+ <\/sup>Tfh \u4ec5\u5b58\u5728\u4e8e TLS \u4e2d\u3002\u5728\u80bf\u7624\u57fa\u8d28\u4e2d\u53ef\u68c0\u6d4b\u5230 NK \u7ec6\u80de\uff0c\u4e00\u4e9bT\u7ec6\u80de\u53ef\u5728\u80bf\u7624\u4e2d\u5fc3\u90e8\u4f4d\u68c0\u6d4b\u5230\u3002\u5de8\u566c\u7ec6\u80de\u3001\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u7b49\u9ad3\u7cfb\u7ec6\u80de\u4ee5\u9ad8\u5bc6\u5ea6\u5b58\u5728\u4e8e\u80bf\u7624\u6d78\u6da6\u8fb9\u7f18\u548c\u80bf\u7624\u4e2d\u5fc3\u3002<\/p>\n

Fig 2.2C \u63d0<\/span><\/span>\u793a\u9760\u8fd1\u80be\u7ec6\u80de\u764c\u6d78\u6da6\u8fb9\u7f18\u6709\u9ad8\u5bc6\u5ea6 \u7684CD163+ M2\u578b\u5de8\u566c\u7ec6\u80de\u3002\u672a\u6210\u719f\u7684\u6811\u7a81\u7ec6\u80de\u4ee5\u4f4e\u5bc6\u5ea6\u5b58\u5728\uff0c\u5206\u6563\u5728\u6574\u4e2a\u80bf\u7624\u533a\u57df\uff0c\u800c\u6210\u719f\u7684\u6811\u7a81\u7ec6\u80de\u901a\u5e38\u5b58\u5728\u4e8eTLS\u5185\uff0c\u4e0eT\u7ec6\u80de\u5bc6\u5207\u63a5\u89e6\uff08Fig 2.2Aa<\/span>\uff09\u3002<\/p>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | Laurence Zitvogel \u2022 Guido Kroemer<\/span><\/p>\n

\u7ffb\u8bd1 |   \u9648\u4f73\u8587 \u9648\u6653\u610f \u7f57\u4f73\u4f73<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u848b\u4fca\u535a<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u5b8b\u4e50 \u9648\u79cb\u8c37<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

<\/section>\n

<\/section>\n

\u2589  \u5f80\u671f\u6587\u7ae0\u76ee\u5f55<\/strong><\/strong><\/p>\n

\u57fa\u7840\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

<\/a>\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c22\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u6740\u4f24\u529f\u80fd<\/span><\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c21\u7ae0\uff1a\u541e\u566c\u7ec6\u80de<\/a>
<\/p>\n

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<\/p>\n

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<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c18\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/a>
<\/p>\n

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<\/p>\n

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<\/p>\n

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<\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c11\u7ae0\uff1a\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c10\u7ae0\uff1a\u6297\u539f\u7684\u5904\u7406\u548c\u5448\u9012<\/a><\/span><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c9\u7ae0\uff1a\u6297\u539f\u8bc6\u522b\u7814\u7a76\u8fdb\u5c55<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c8\u7ae0\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269MHC<\/a><\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c7\u7ae0\uff1aT\u7ec6\u80de\u53d7\u4f53(TCR)\u6982\u8ff0<\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c6\u7ae0\uff1a\u6297\u4f53\u591a\u6837\u6027<\/a><\/p>\n

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\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c3\u7ae0\uff1a\u6297\u539f\u8bc6\u522b<\/a><\/span><\/p>\n

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<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057-\u7b2c1\u7ae0\uff1a\u514d\u75ab\u7cfb\u7edf\u7b80\u4ecb<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c1\u7ae0\uff1a\u80bf\u7624\u514d\u75ab\u7b80\u53f2<\/a>
<\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217\u66f4\u65b0\u9884\u544a<\/a>
<\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c7\u5929)-210608<\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c6\u5929)-210607<\/a>
<\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c5\u5929)-210605<\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c4\u5929)-210604<\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c3\u5929)-210603<\/span><\/a>
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\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c1\u5929)-20210531<\/a><\/span><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0(\u7b2c2\u5929)-20210601<\/a><\/p>\n

TCGA\u514d\u75ab\u6d78\u6da6\u8bc4\u4ef7\u6570\u636e\u5e93<\/a>
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ggplot2|\u8be6\u89e3\u516b\u5927\u57fa\u672c\u7ed8\u56fe\u8981\u7d20<\/a>
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Python\u96c6\u6210\u5f00\u53d1\u73af\u5883PyCharm\u7684\u5b89\u88c5\u4e0e\u6fc0\u6d3b<\/a>
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Python\u53d1\u884c\u7248Anaconda\u7684\u5b89\u88c5\u4e0e\u4f7f\u7528<\/a><\/p>\n

\u57fa\u7840\u5b9e\u9a8c\u6280\u672f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u6d41\u5f0f\u68c0\u6d4b\u7ec6\u80de\u603bROS-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span>
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Annexin V\/PI\u67d3\u8272\u68c0\u6d4b\u7ec6\u80de\u51cb\u4ea1-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u514d\u75ab\u8367\u5149\u5b9e\u9a8c-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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WB\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a><\/span><\/p>\n

QPCR\u5b9e\u9a8c\u64cd\u4f5c\u89c6\u9891-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u4eea\u5668\u64cd\u4f5c\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u5c0f\u52a8\u7269\u6d3b\u4f53\u5149\u5b66\u6210\u50cf\u7cfb\u7edf\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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\u8521\u53f8LSM800\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u64cd\u4f5c\u89c6\u9891-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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IN Cell Analyzer2200\u9ad8\u5185\u6db5\u7ec6\u80de\u6210\u50cf\u5206\u6790\u7cfb\u7edf\u64cd\u4f5c\u6559\u7a0b-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a>
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BD LSR Fortessa\u6d41\u5f0f-\u4e2d\u897f\u533b\u7ed3\u5408\u57fa\u7840\u7814\u7a76\u4e2d\u5fc3<\/a><\/span><\/p>\n

\u6587\u732e\u5206\u4eab\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u80bf\u7624\u4ee3\u8c22\u91cd\u7f16\u7a0b\u4e0e\u514d\u75ab\u5e94\u7b54<\/a>
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\u5e74\u5ea6\u5de8\u732e\uff1a\u795e\u520aCA\u53d1\u5e03\u6700\u65b0\u764c\u75c7\u6570\u636e\uff1a\u5168\u74031000\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\uff0c\u4e2d\u56fd\u5360\u6bd4\u8d853\u6210<\/a>
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HLA-I\u5206\u5b50\u52a0\u5de5\u548c\u9012\u5448\u6297\u539f\u529f\u80fd\u53d7\u635f\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u7684\u91cd\u8981\u539f\u56e0<\/a>
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PD-1\/PD-L1\u963b\u65ad\u5242\u6cbb\u7597\u80bf\u7624\u7684\u7814\u7a76\u8fdb\u5c55\u4e0e\u9762\u4e34\u7684\u6311\u6218<\/a><\/span><\/p>\n

Immunity\uff1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u5341\u5927\u6311\u6218<\/span><\/a><\/p>\n

\u4f5c\u56fe\u6295\u7a3f\u9009\u520a\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

GraphPad+AI\u5236\u4f5c\u53ef\u53d1\u8868\u7ea7\u522b\u7684\u67f1\u72b6\u56fe-OncoLab\u5b9e\u9a8c\u5ba4<\/a>
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\u5982\u4f55\u4f7f\u7528ImageJ\u8fdb\u884c\u7ec6\u80de\u8367\u5149\u5b9a\u91cf<\/a>
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\u5982\u4f55\u4f7f\u7528Scrivener\u8fdb\u884c\u79d1\u6280\u8bba\u6587\u5199\u4f5c<\/a>
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Mendeley-\u6700\u597d\u7528\u7684\u6587\u732e\u9605\u8bfb\u7ba1\u7406\u8f6f\u4ef6\uff0c\u6ca1\u6709\u4e4b\u4e00<\/a>
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\u5982\u4f55\u9009\u62e9\u4e00\u4e2a\u5408\u9002\u7684\u6742\u5fd7\u8fdb\u884c\u6295\u7a3f\uff1f<\/a>
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PubMed\u4e2d\u5982\u4f55\u6309\u5f71\u54cd\u56e0\u5b50\u7b5b\u9009\u68c0\u7d22\u7ed3\u679c\u5e76\u663e\u793a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\uff1f<\/a>
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\u5982\u4f55\u4f7f\u7528EndNote\u8f6f\u4ef6\u63d2\u5165\u53c2\u8003\u6587\u732e\uff08\u96446813\u79cd\u6742\u5fd7\u53c2\u8003\u6587\u732e\u683c\u5f0f\u6587\u4ef6\uff09<\/a><\/span><\/p>\n

\u5065\u5eb7\u517b\u751f\u7cfb\u5217<\/strong><\/strong><\/span><\/p>\n

\u516b\u6bb5\u9526\uff08\u89c6\u9891\u7248+\u56fe\u7247\u7248\uff0c\u63a8\u8350\u6536\u85cf\uff09<\/span><\/a>
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\u70b9\u4eae\u201c\u5728\u770b\u201d<\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230\uff01<\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u63d2\u64ad\u4e00\u6761\u5e7f\u544a\uff0c\u672c\u5b9e\u9a8c\u5ba4\u6709\u57fa\u7840\u533b\u5b66(\u514d\u75ab\u5b66)\u7814\u7a76\u751f\u62db\u751f\u540d\u989d\u5c11\u91cf(\u53ef\u63a5\u53d7\u63a8\u514d)\uff0c\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u501f\u52a9\u5355\u7ec6\u80de\u5206\u6790\u6280\u672f\u63a2…<\/p>\n","protected":false},"author":1,"featured_media":2148,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2153"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=2153"}],"version-history":[{"count":1,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2153\/revisions"}],"predecessor-version":[{"id":2258,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2153\/revisions\/2258"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/2148"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=2153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=2153"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=2153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}