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border-box;\">\u80bf\u7624\u6d78\u6da6\u5de8\u566c\u7ec6\u80de\u53ef\u4ee5\u5206\u4e3a\u7ecf\u5178\u6d3b\u5316(M1)\u5de8\u566c\u7ec6\u80de\u548c\u4ea4\u66ff\u6d3b\u5316(M2)\u5de8\u566c\u7ec6\u80de\u3002M1\u5de8\u566c\u7ec6\u80de\u5bb9\u6613\u901a\u8fc7\u4ea7\u751f\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176(nitric oxide synase, iNOS)\u53c2\u4e0e\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u76f8\u53cd\uff0cM2\u5de8\u566c\u7ec6\u80de\u8868\u73b0\u51fa\u6297\u708e\u8868\u578b\uff0c\u4f1a\u5206\u6ccc\u8bb8\u591a\u4fc3\u80bf\u7624\u56e0\u5b50\uff0c\u5982arginase 1 (ARG1)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u867d\u7136Ns\u662f\u53c2\u4e0e\u708e\u75c7\u8fc7\u7a0b\u7684\u91cd\u8981\u514d\u75ab\u7ec6\u80de\uff0c\u4f46\u5b83\u4eec\u4ee5\u4e24\u79cd\u4e0d\u540c\u7684\u65b9\u5f0f\u5f71\u54cdTME\u3002N1\u4e9a\u578b\u5206\u6ccc\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u5f15\u8d77\u7ec6\u80de\u6bd2\u6027\u514d\u75ab\u53cd\u5e94\uff0cN2\u4e9a\u578b\u88ab\u8ba4\u4e3a\u662f\u514d\u75ab\u6291\u5236\u7ec6\u80de\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">MDSCs\u662f\u4e00\u7ec4\u4e0d\u6210\u719f\u7684\u9ad3\u7ec6\u80de\uff0c\u5728\u6291\u5236\u80bf\u7624\u7684\u53d1\u5c55\u3001\u8f6c\u79fb\u548c\u6cbb\u7597\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u6839\u636e\u5176\u6765\u6e90\u3001\u7ec4\u7ec7\u5b9a\u4f4d\u548c\u514d\u75ab\u6291\u5236\u673a\u5236\uff0cMDSCs\u53ef\u5206\u4e3a\u5355\u6838\u7ec6\u80deMDSCs\u548c\u591a\u5f62\u6838MDSCs\u3002\u5b83\u4eec\u901a\u8fc7\u6291\u5236\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7684\u65b9\u5f0f\u8868\u73b0\u51fa\u514d\u75ab\u6291\u5236\u80fd\u529b\uff0c\u800c\u8be5\u80fd\u529b\u4e0e\u5176\u6240\u5728\u73af\u5883\u6709\u5173\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0cNK\u7ec6\u80de\u548cDC\u88ab\u8ba4\u4e3a\u5728\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u4e2d\u4e5f\u53d1\u6325\u4e86\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4f46\u5404\u79cd\u514d\u75ab\u6291\u5236\u56e0\u5b50\u5f80\u5f80\u4f1a\u6291\u5236\u5176\u80fd\u529b\uff0c\u4f7f\u5176\u6210\u4e3a\u4fc3\u80bf\u7624\u8868\u578b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u514d\u75ab\u7ec6\u80de\u5916\uff0c\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de(CAFs)\u662f\u80bf\u7624\u95f4\u8d28\u7684\u4e3b\u8981\u6210\u5206\uff0c\u5bf9TME\u7684\u5f62\u6210\u6709\u91cd\u8981\u4f5c\u7528\u3002CAFs\u53ef\u901a\u8fc7\u6c89\u79ef\u3001\u91cd\u5851\u7ec6\u80de\u5916\u57fa\u8d28\u3001\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u6216\u4e0e\u7ec6\u80de\u76f4\u63a5\u63a5\u89e6\uff0c\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u5411\u6076\u6027\u8868\u578b\u8f6c\u5316\uff0c\u589e\u5f3a\u80bf\u7624\u7ec6\u80de\u9003\u907f\u514d\u75ab\u68c0\u6d4b\u548c\u6d88\u9664\u7684\u80fd\u529b\uff0c\u8c03\u8282\u5176\u4ed6\u80bf\u7624\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u7ec6\u80de\u751f\u5b58\u4e2d\u80fd\u91cf\u548c\u4ee3\u8c22\u4ea7\u7269\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002\u6076\u6027\u80bf\u7624\u7ec6\u80de\u9700\u8981\u5927\u91cf\u7684\u80fd\u91cf\u548c\u539f\u6599\u6765\u652f\u6301\u5176\u4e0d\u53d7\u63a7\u5236\u7684\u589e\u6b96\u548c\u5bf9\u5b50\u7ec6\u80de\u7684\u7ef4\u6301\u3002\u867d\u7136TME\u5185\u8840\u7ba1\u751f\u6210\u589e\u52a0\uff0c\u4f46\u8461\u8404\u7cd6\u548c\u6c27\u6c14\u7684\u91cf\u4ec5\u80fd\u6ee1\u8db3\u764c\u7ec6\u80de\u6269\u5f20\u548c\u6269\u6563\u7684\u9700\u6c42\uff0c\u56e0\u6b64\u4f1a\u5bfc\u81f4\u8461\u8404\u7cd6\u7f3a\u4e4f\u548c\u7f3a\u6c27\u7684\u5fae\u73af\u5883\u3002\u8fd9\u4f1a\u8feb\u4f7f\u6076\u6027\u80bf\u7624\u7ec6\u80de\u8c03\u6574\u5176\u4ee3\u8c22\u8c31\u4ee5\u7ef4\u6301\u81ea\u8eab\u7684\u589e\u6b96\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">20\u4e16\u7eaa20\u5e74\u4ee3\uff0cOtto Warburg\u7b49\u4eba\u9996\u6b21\u63d0\u51fa\uff0c\u65e0\u8bbaTME\u4e2d\u542b\u6c27\u91cf\u5982\u4f55\uff0c\u80bf\u7624\u7ec4\u7ec7\u5728\u7ed9\u5b9a\u65f6\u95f4\u5185\u4ee3\u8c22\u8461\u8404\u7cd6\u8f6c\u5316\u6210\u4e73\u9178\u7684\u91cf\u5927\u7ea6\u662f\u6b63\u5e38\u7ec4\u7ec7\u768410\u500d\uff0c\u8fd9\u88ab\u79f0\u4e3aWarburg\u6548\u5e94\u3002\u6b64\u540e\uff0c\u4ee3\u8c22\u91cd\u7f16\u7a0b\u6210\u4e3a\u6076\u6027\u80bf\u7624\u7814\u7a76\u4e2d\u4e00\u4e2a\u5341\u5206\u5177\u6709\u7814\u7a76\u524d\u666f\u7684\u9886\u57df(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 1<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd1\u5e74\u6765\uff0c\u8102\u8d28\u5bf9\u80bf\u7624\u53d1\u5c55\u7684\u5f71\u54cd\u8d8a\u6765\u8d8a\u53d7\u5230\u4eba\u4eec\u7684\u5173\u6ce8\u3002\u8102\u8d28\u9664\u4e86\u88ab\u7528\u4f5c\u673a\u4f53\u80fd\u91cf\u77ed\u7f3a\u65f6\u7684\u66ff\u4ee3\u80fd\u6e90\u5916\uff0c\u8fd8\u53c2\u4e0e\u751f\u7269\u819c\u7684\u5408\u6210\uff0c\u4e3a\u751f\u7269\u8d28\u751f\u4ea7\u63d0\u4f9b\u57fa\u8d28\uff0c\u5e76\u6fc0\u6d3b\u4e0e\u764c\u7ec6\u80de\u751f\u957f\u548c\u8fc1\u79fb\u76f8\u5173\u7684\u590d\u6742\u4fe1\u53f7\u901a\u8def\u3002\u764c\u7ec6\u80de\u4f1a\u8868\u73b0\u51fa\u8102\u8d28\u548c\u80c6\u56fa\u9187\u9700\u6c42\u589e\u52a0\u7684\u73b0\u8c61\uff0c\u5982\u5916\u6e90\u6027\u8102\u8d28\u548c\u8102\u86cb\u767d\u6444\u5165\u589e\u52a0\uff0c\u53ca\u8102\u8d28\u548c\u80c6\u56fa\u9187\u7684\u4ece\u5934\u5408\u6210\u8fc7\u5ea6\u6fc0\u6d3b\uff0c\u90fd\u4f1a\u76f4\u63a5\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u7684\u6076\u6027\u8f6c\u5316\u548c\u8f6c\u5316\u8fdb\u5c55\uff0c\u53caTME\u4e2d\u7684\u8102\u8d28\u5f02\u5e38\u79ef\u7d2f(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 1<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">TME\u4e2d\u7684\u8102\u8d28\u4ee3\u8c22\u969c\u788d\u5bf9\u80bf\u7624\u76f8\u5173\u514d\u75ab\u53cd\u5e94\u5177\u6709\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u6839\u636e\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u4f5c\u7528\uff0c\u514d\u75ab\u5e94\u7b54\u53ef\u5206\u4e3a\u4fc3\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u548c\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u4e24\u8005\u5747\u6d89\u53ca\u591a\u79cd\u514d\u75ab\u7ec6\u80de\uff0c\u5982T\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001DCs\u3001MDSCs\u7b49\u3002\u7531\u4e8e\u8102\u8d28\u7684\u590d\u6742\u7ec4\u6210\u548c\u6f5c\u5728\u7684\u673a\u5236\uff0c\u540c\u4e00\u7c7b\u578b\u7684\u514d\u75ab\u7ec6\u80de\u53ef\u80fd\u5bf9\u8102\u8d28\u4ee3\u8c22\u7684\u53d8\u5316\u4f5c\u51fa\u975e\u5e38\u4e0d\u540c\u7684\u53cd\u5e94\uff0c\u4ece\u800c\u5f97\u4f7f\u7814\u7a76\u5f97\u51fa\u6a21\u68f1\u4e24\u53ef\u7684\u7ed3\u8bba\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4f8b\u5982\uff0c\u8fc7\u91cf\u7684\u6e38\u79bb\u8102\u80aa\u9178(FFAs)\u6291\u5236CTL\u4ecb\u5bfc\u7684\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\uff0c\u53ef\u4ee5\u901a\u8fc7\u964d\u4f4eFFA\u6c34\u5e73\u6765\u6062\u590d\u3002\u7136\u800c\uff0c\u5728\u4e25\u9177\u7684TME\u4e2d\uff0c\u7ec4\u7ec7\u9a7b\u7559\u8bb0\u5fc6(Trm)\u7ec6\u80de\u503e\u5411\u4e8e\u901a\u8fc7CD36\u5438\u6536FAs\u6765\u652f\u6301\u6297\u80bf\u7624\u53cd\u5e94\u548c\u7ef4\u6301\u5b83\u4eec\u81ea\u8eab\u7684\u957f\u671f\u751f\u5b58\u3002\u56e0\u6b64\uff0c\u786e\u5b9a\u514d\u75ab\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7684\u786e\u5207\u673a\u5236\u5bf9\u4e8e\u7406\u89e3\u514d\u75ab\u6291\u5236\u73b0\u8c61\u548c\u5f00\u53d1\u6709\u6548\u7684\u8054\u5408\u7597\u6cd5\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u672c\u6587\u4e2d\uff0c\u6211\u4eec\u4ece\u4e24\u4e2a\u89d2\u5ea6\u8ba8\u8bba\u4e86\u8102\u8d28\u4ee3\u8c22\u5bf9\u80bf\u7624\u76f8\u5173\u514d\u75ab\u53cd\u5e94\u7684\u590d\u6742\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u63a2\u8ba8\u4e86\u76ee\u524d\u9488\u5bf9TME\u4e2d\u8102\u8d28\u4ee3\u8c22\u7684\u7b56\u7565\u548c\u5206\u5b50\u9776\u70b9\uff0c\u5e76\u63cf\u8ff0\u4e86\u5176\u5c40\u9650\u6027\u548c\u672a\u6765\u7684\u53d1\u5c55\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: flex;flex-flow: row nowrap;margin: 20px 0% 10px;justify-content: flex-start;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;box-sizing: border-box;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8102\u8d28\u4ee3\u8c22\u7684\u57fa\u672c\u6982\u5ff5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u6839\u636e\u5176\u7ed3\u6784\u53ef\u5206\u4e3a\u4e09\u5927\u7c7b:(a)\u542b\u6709\u957f\u94feFAs\u53ca\u5176\u916f\u5316\u4ea7\u7269\u7684\u7b80\u5355\u8102\u8d28\uff0c\u5982\u4e09\u9170\u57fa\u7518\u6cb9(TAG); (b)\u884d\u751f\u8102\u8d28\uff0c\u5982\u7c7b\u56fa\u9187\u3001\u8102\u6eb6\u6027\u7ef4\u751f\u7d20\u548c\u7c7b\u80e1\u841d\u535c\u7d20;(c)\u542b\u6709\u5404\u79cd\u5b98\u80fd\u56e2\u7684\u590d\u5408\u8102\u8d28\uff0c\u5982\u78f7\u8102\u3001\u7cd6\u8102\u8d28\u548c\u8102\u86cb\u767d(LP)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7166667\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-4d8d5be095e8d16e0f829fce334ce5a2.png\"  \/><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: justify;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 1<\/span> \u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u4ee3\u8c22\u91cd\u7f16\u7a0b\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u7d0a\u4e71\u7684\u8840\u7ba1\u8fd0\u8f93\u7684\u8461\u8404\u7cd6\u548c\u6c27\u6c14\u5927\u90e8\u5206\u88ab\u80bf\u7624\u7ec6\u80de\u5438\u6536\uff0c\u5bfc\u81f4\u7f3a\u6c27\u548c\u7f3a\u7cd6\u7684\u5fae\u73af\u5883\u3002\u80bf\u7624\u7ec6\u80de\u4e2d\u6fc0\u6d3b\u7684\u7cd6\u9175\u89e3\u80fd\u4ea7\u751f\u66f4\u591a\u7684\u4e73\u9178\uff0c\u4f46\u4ecd\u4e0d\u80fd\u6ee1\u8db3\u80fd\u91cf\u9700\u6c42\u3002\u56e0\u6b64\uff0c\u6765\u81ea\u80bf\u7624\u7ec6\u80de\u548c\u5176\u4ed6\u57fa\u8d28\u7ec6\u80de\u7684LPL(\u8102\u86cb\u767d\u8102\u80aa\u9176)\u6fc0\u6d3b\u8102\u80aa\u7ec6\u80de\uff0c\u8bf1\u5bfc\u50a8\u5b58\u7684\u7518\u6cb9\u4e09\u916f\u7684\u8102\u89e3\u548cFAs(\u8102\u80aa\u9178\uff09\u7684\u5206\u6ccc\uff0c\u5e76\u901a\u8fc7CD36\u6216FATPs\uff08\u8102\u80aa\u9178\u8f6c\u8fd0\u86cb\u767d\uff09\u8f6c\u8fd0\u5230\u7ec6\u80de\u5185\u3002\u6b64\u5916\uff0c\u80bf\u7624\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u8461\u8404\u7cd6\u5206\u89e3\u4ee3\u8c22\uff0c\u5229\u7528\u4e59\u9170\u8f85\u9176a\u901a\u8fc7\u4ece\u5934\u5408\u6210\u9014\u5f84\u751f\u6210FAs\uff08\u8102\u80aa\u9178\uff09\u3002ACC(\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176)\u548cFASN\uff08\u8102\u80aa\u9178\u5408\u6210\u9176\uff09\u53c2\u4e0e\u8fd9\u4e00\u8fc7\u7a0b\u3002\u8fd9\u4e9bFAs\u968f\u540e\u53c2\u4e0eFAO\uff08\u8102\u80aa\u9178\u6c27\u5316\uff09\u6216\u5176\u4ed6\u4fe1\u53f7\u901a\u8def\uff0c\u4ea7\u751f\u8bb8\u591a\u514d\u75ab\u6291\u5236\u56e0\u5b50\u6216\u4ea7\u751fLDs\uff08\u8102\u6ef4\uff09\u3002\u6b64\u5916\uff0cTME\u4e2d\u7684\u8102\u86cb\u767d\u901a\u8fc7\u8102\u86cb\u767d\u53d7\u4f53(lipoprotein receptor, LRs)\u8fd0\u8f93\uff0c\u5e76\u5728\u7ec6\u80de\u4e2d\u5206\u89e3\u4e3a\u80c6\u56fa\u9187\u3002\u80bf\u7624\u7ec6\u80de\u4e5f\u53ef\u4ee5\u901a\u8fc7\u7532\u620a\u9178\u9014\u5f84\u4ea7\u751f\u80c6\u56fa\u9187\u3002\u80bf\u7624\u7ec6\u80de\u7684\u8102\u8d28\u4ee3\u8c22\u5f02\u5e38\u4fc3\u8fdb\u4e86\u9178\u6027\u3001\u7f3a\u6c27\u3001\u7f3a\u7cd6\u548c\u9ad8\u8102\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u5f62\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u80aa\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5916\u6e90\u6027FAs\u4e3b\u8981\u6765\u6e90\u4e8eTAGs, TAGs\u4e3b\u8981\u5728\u7a7a\u80a0\u4e0a\u7aef\u88ab\u80f0\u8102\u80aa\u9176\u50ac\u5316\u6d88\u5316\u3002\u8fd9\u4e9bFFAs\u901a\u8fc7CD36\u6216\u8102\u80aa\u9178\u8f6c\u8fd0\u86cb\u767d(FATP)\u4ece\u80a0\u8154\u88ab\u5438\u6536\u5230\u80a0\u4e0a\u76ae\u7ec6\u80de\uff0c\u7136\u540e\u901a\u8fc7\u5355\u9170\u57fa\u7518\u6cb9\u9170\u57fa\u8f6c\u79fb\u9176\u548c\u4e8c\u9170\u57fa\u7518\u6cb9\u9170\u57fa\u8f6c\u79fb\u9176\u91cd\u65b0\u7ec4\u88c5\u6210TAG\u3002\u4e3a\u4e86\u5728\u8840\u6db2\u4e2d\u8fd0\u8f93\uff0cTAGs\u901a\u5e38\u4e0e\u8102\u591a\u7cd6\u7ed3\u5408\uff0c\u5f62\u6210\u4e73\u7cdc\u5fae\u7c92\u3001\u6781\u4f4e\u5bc6\u5ea6\u8102\u591a\u7cd6(VLDL)\u3001\u4f4e\u5bc6\u5ea6\u8102\u591a\u7cd6(LDL)\u548c\u9ad8\u5bc6\u5ea6\u8102\u591a\u7cd6(HDL)\u3002\u8102\u591a\u7cd6\u53ef\u88ab\u8102\u86cb\u767d\u8102\u80aa\u9176(LPL)\u6c34\u89e3\u6216\u901a\u8fc7\u76f8\u5e94\u53d7\u4f53\u8f6c\u8fd0\u5230\u7ec6\u80de\u5185\uff0c\u751f\u6210FAs\u548c\u86cb\u767d\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4ece\u5934\u5408\u6210\u662fFAs\u7684\u53e6\u4e00\u4e2a\u4e3b\u8981\u6765\u6e90\u3002ATP -\u67e0\u6aac\u9178\u88c2\u89e3\u9176(ACLY)\u50ac\u5316\u67e0\u6aac\u9178\u8f6c\u5316\u4e3a\u4e59\u9170\u8f85\u9176A (acetyl-CoA)\uff0c\u7136\u540e\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176(acetyl-CoA carboxylase, ACC)\u5c06\u4e59\u9170\u8f85\u9176A\u8f6c\u5316\u4e3a\u4e19\u4e8c\u9170\u8f85\u9176A\u3002\u8102\u80aa\u9178\u5408\u6210\u9176(FASN)\u901a\u8fc7\u4e59\u9170\u8f85\u9176a\u548c\u4e19\u4e8c\u9170\u8f85\u9176a\u7684\u53cd\u590d\u7f29\u5408\u751f\u6210\u68d5\u6988\u9178\uff0c\u68d5\u6988\u9178\u901a\u8fc7\u8fdb\u4e00\u6b65\u4f38\u957f\u548c\u53bb\u9971\u548c\u4f5c\u7528\u8f6c\u5316\u4e3a\u8bb8\u591a\u5176\u4ed6\u7c7b\u578b\u7684FAs(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table 1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u7ec6\u80de\u4e2d\uff0cFAs\u4e3b\u8981\u901a\u8fc7\u8102\u80aa\u9178\u6c27\u5316(FAO)\u4f5c\u4e3a\u4e00\u79cd\u80fd\u91cf\u6765\u6e90\u3002\u8102\u80aa\u9170\u57fa\u8f85\u9176A\u5408\u6210\u9176(ACS)\u548c\u8089\u78b1\u68d5\u6988\u9170\u8f6c\u79fb\u9176I (CPT1)\u662f\u751f\u6210\u8102\u80aa\u9170\u57fa\u8f85\u9176A\u548c\u8102\u80aa\u9170\u57fa\u8089\u78b1\u7684\u5173\u952e\u9176\u3002\u9170\u57fa\u8089\u78b1\u8fdb\u5165\u7ebf\u7c92\u4f53\u540e\uff0c\u8f6c\u5316\u4e3a\u9170\u57fa\u8f85\u9176a\uff0c\u8fdb\u5165\u4e09\u7fa7\u9178\u5faa\u73af\u751f\u6210\u4e09\u78f7\u9178\u817a\u82f7 (ATP)\u548c\u70df\u9170\u80fa\u817a\u560c\u5464\u4e8c\u6838\u82f7\u9178\u78f7\u9178(NADP)\uff0c\u4ece\u800c\u62b5\u6d88\u6c27\u5316\u5e94\u6fc0\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0cFAs\u901a\u8fc7\u7ed3\u5408\u548c\u6fc0\u6d3b\u6838\u53d7\u4f53\u5bb6\u65cf\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u5982\u8fc7\u901a\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u4f53(PPARS)\u6765\u8c03\u8282\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\u548c\u57fa\u56e0\u8f6c\u5f55\uff0cPPARS\u63a7\u5236\u8102\u8d28\u3001\u80fd\u91cf\u7a33\u6001\u548c\u708e\u75c7\u76f8\u5173\u57fa\u56e0\u7684\u8868\u8fbe\u3002PPAR-\u03b1\u76f4\u63a5\u4e0a\u8c03CPT1\u03b1\u548cPPAR-\u03b4\u7684\u8868\u8fbe\uff0c\u8c03\u8282\u8102\u8d28\u8f93\u9001\u548c\u6c27\u5316\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u56fa\u9187\u8c03\u8282\u5143\u4ef6\u7ed3\u5408\u86cb\u767d1 (SREBP-1)\u8f6c\u5f55\u56e0\u5b50\u5f71\u54cd\u53c2\u4e0e\u8102\u4ee3\u8c22\u7684\u57fa\u56e0\u5982ACLY\u3001ACC\u548cFASN[30]\u7684\u8868\u8fbe(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table&nbsp;1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.4212963\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-4b4752b83cc1669aa6f2a177710d6736.png\"  \/><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table&nbsp;1<\/span>&nbsp;<span style=\"box-sizing: border-box;\">\u521d\u7ea7\u8102\u8d28\u7684\u57fa\u672c\u6982\u5ff5<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u80c6\u56fa\u9187<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u80c6\u56fa\u9187\u662f\u8102\u8d28\u4ee3\u8c22\u4e0d\u53ef\u7f3a\u5c11\u7684\u7ec4\u6210\u90e8\u5206\u3002\u5b83\u7684\u5438\u6536\u4f34\u968f\u7740FAs\u901a\u8fc7CD36\u548c\u5c3c\u66fc- pick C1 like 1\uff0c\u7136\u540e\u5b83\u4eec\u91cd\u65b0\u7ec4\u88c5\u6210\u4e73\u7cdc\u5fae\u7c92\u3002\u4e0eFAs\u7c7b\u4f3c\uff0c\u809d\u810f\u4e2d\u80c6\u56fa\u9187\u88ab\u5305\u88c5\u6210\u975e\u5e38\u4f4e\u5bc6\u5ea6\u7684\u8102\u591a\u7cd6\u548c\u4f4e\u5bc6\u5ea6\u8102\u591a\u7cd6\uff0c\u5e76\u5728\u5faa\u73af\u4e2d\u8fd0\u8f93\u3002\u8fd9\u4e9b\u8102\u591a\u7cd6\u901a\u8fc7\u76f8\u5e94\u7684\u53d7\u4f53\u8fdb\u5165\u7ec6\u80de\u540e\uff0c\u88ab\u6eb6\u9176\u4f53\u4e2d\u7684\u80c6\u56fa\u9187\u916f\u6c34\u89e3\u9176\u6c34\u89e3\u91ca\u653e\u80c6\u56fa\u9187\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7136\u800c\uff0c\u996e\u98df\u6765\u6e90\u7684\u80c6\u56fa\u9187\u4e0d\u80fd\u6ee1\u8db3\u751f\u7406\u9700\u6c42\uff0c\u5176\u901a\u8fc7\u7532\u620a\u9178\u9014\u5f84\u7684\u4ece\u5934\u5408\u6210\u624d\u662f\u80c6\u56fa\u9187\u7684\u91cd\u8981\u6765\u6e90\u30023-\u7f9f\u57fa-3-\u7532\u57fa\u620a\u4e8c\u9170\u57fa\u8f85\u9176A\u8fd8\u539f\u9176(HMGCR)\u662f\u8be5\u8fc7\u7a0b\u4e2d\u7684\u9650\u901f\u9176\uff0c\u4ecb\u5bfc3-\u7f9f\u57fa-3-\u7532\u57fa\u620a\u4e8c\u9170\u57fa\u8f85\u9176A\u8f6c\u5316\u4e3a\u7532\u620a\u9178\uff0c\u7532\u620a\u4e8c\u9170\u57fa\u8f85\u9176A\u8fdb\u5165\u4e0b\u6e38\u8fdb\u884c\u591a\u6b65\u5408\u6210(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table&nbsp;1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e3a\u4e86\u907f\u514d\u6e38\u79bb\u7ec6\u80de\u95f4\u80c6\u56fa\u9187\u5927\u91cf\u79ef\u7d2f\u800c\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\uff0c\u9170\u57fa\u8f85\u9176a -\u80c6\u56fa\u9187\u9170\u57fa\u8f6c\u79fb\u9176(ACAT)\u5c06\u80c6\u56fa\u9187\u8f6c\u5316\u4e3a\u80c6\u56fa\u9187\u916f(CE)\uff0c\u5e76\u5c06\u5176\u50a8\u5b58\u5728\u8102\u6ef4\u4e2d(ID)\u3002ACAT2\u7f3a\u4e4f\u53ef\u663e\u8457\u964d\u4f4e\u80c6\u56fa\u9187\u7684\u5438\u6536\u901f\u7387\uff0c\u6fc0\u6d3bSREBP\uff0c\u589e\u5f3aHMGCR\u3001\u8102\u86cb\u767d\u53d7\u4f53(LDLR)\u7b49\u8bb8\u591a\u8c03\u8282\u86cb\u767d\u7684\u8f6c\u5f55\uff0c\u589e\u52a0\u80c6\u56fa\u9187\u7684\u6444\u53d6\u548c\u5408\u6210\u3002\u6b64\u5916\uff0cATP\u7ed3\u5408\u76d2(ABC)\u86cb\u767d\u4f1a\u4ecb\u5bfc\u7ec6\u80de\u5185\u80c6\u56fa\u9187\u5916\u6d41\uff0c\u5c24\u5176\u662f\u5de8\u566c\u7ec6\u80de\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u809d\u810fX\u53d7\u4f53(Liver X receptor, LXR)\u4fc3\u8fdb\u8102\u80aa\u751f\u6210\u548cABCA1\u3001ABCG1\u7684\u8f6c\u5f55\u3002\u8bb8\u591a\u7269\u7406\u8fc7\u7a0b\u4f9d\u8d56\u4e8e\u80c6\u56fa\u9187\uff0c\u5982\u8d28\u819c\u3001\u5c0f\u6ce1\u548c\u8102\u8d28\u7684\u5f62\u6210\uff0c\u4e00\u4e9b\u5982dolichoL\u548c\u8f85\u9176Q\u7684\u5206\u5b50\u7684\u751f\u7269\u5408\u6210\u3001\u4ee5\u53ca\u4ee3\u8c22\u7269\u7684\u7ed3\u6784\u9aa8\u5e72\u5f62\u6210\u3002\u7136\u800c\uff0c\u8fc7\u591a\u7684\u80c6\u56fa\u9187\u4f1a\u964d\u4f4e\u819c\u6d41\u52a8\u6027\uff0c\u7834\u574f\u8102\u8d28\u4fe1\u53f7\uff0c\u4ea7\u751f\u7834\u574f\u6027\u7684\u6c27\u5316\u5206\u5b50\uff0c\u6700\u7ec8\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table&nbsp;1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u6ef4<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">LDs\u662f\u4e00\u79cd\u91cd\u8981\u7684\u4e9a\u7ec6\u80de\u5668\uff0c\u901a\u8fc7\u7ef4\u6301\u8102\u8d28\u50a8\u5b58\u548c\u5206\u89e3\u7684\u5e73\u8861\u6765\u8c03\u8282\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\uff0c\u5e76\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u6f5c\u5728\u7684\u6709\u6bd2\u8102\u8d28\u7684\u4fb5\u5bb3\u3002LD\u5305\u542b\u4e00\u4e2a\u7531TAG\u3001\u56fa\u9187\u916f\u548cFFAs\u7ec4\u6210\u7684\u8102\u8d28\u6838\uff0c\u5b83\u88ab\u4e00\u4e2a\u7531\u78f7\u8102\u548c\u80c6\u56fa\u9187\u7ec4\u6210\u7684\u5355\u5c42\u819c\u5305\u56f4\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u4ee3\u8c22\u4e2d\u6d89\u53ca\u7684\u5404\u79cd\u9176\u548c\u86cb\u767d\uff0c\u5982\u8102\u80aa\u7518\u6cb9\u4e09\u916f\u8102\u80aa\u9176(ATGL)\u3001\u6fc0\u7d20\u654f\u611f\u8102\u80aa\u9176(HSL)\u3001\u5355\u9170\u57fa\u7518\u6cb9\u8102\u80aa\u9176(MAGL)\u3001\u6eb6\u9176\u4f53\u9178\u6027\u8102\u80aa\u9176(LAL)\u7b49\u90fd\u4f4d\u4e8eLDs\u8868\u9762\uff0c\u53c2\u4e0e\u8102\u8d28\u4ee3\u8c22\u7684\u8c03\u8282\u3002PPAR\u6fc0\u52a8\u5242\u3001\u7cd6\u76ae\u8d28\u6fc0\u7d20\u548c\u7981\u98df\u4f1a\u63d0\u9ad8ATGL\u8868\u8fbe\uff0c\u800c\u80f0\u5c9b\u7d20\u548c\u98df\u7269\u6444\u5165\u5219\u6709\u76f8\u53cd\u7684\u4f5c\u7528(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table 1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728TME\u4e2d\uff0c\u8fd9\u4e9b\u590d\u6742\u7684\u8102\u8d28\u6210\u5206\u53ca\u5176\u4ee3\u8c22\u8fc7\u7a0b\u53d7\u5230\u5f02\u5e38\u8c03\u8282\uff0c\u4ece\u800c\u5bf9\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: flex;flex-flow: row nowrap;margin: 20px 0% 10px;justify-content: flex-start;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;box-sizing: border-box;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8102\u8d28\u5728\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u4e2d\u7684\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">TME\u4e2d\u8840\u7ba1\u4ea4\u6362\u4e0d\u8db3\u5bfc\u81f4\u7684\u8425\u517b\u9650\u5236\u53ef\u5bfc\u81f4\u514d\u75ab\u7ec6\u80de\u4e0e\u5feb\u901f\u589e\u6b96\u7684\u764c\u7ec6\u80de\u4e4b\u95f4\u7684\u6fc0\u70c8\u7ade\u4e89\uff0c\u4ece\u800c\u6539\u53d8\u6297\u80bf\u7624\u514d\u75ab\u9632\u5fa1\u529f\u80fd\u3002\u514d\u75ab\u7ec6\u80de\u548c\u514d\u75ab\u4ecb\u8d28\u88ab\u6fc0\u6d3b\u53c2\u4e0e\u5bbf\u4e3b\u5bf9\u6076\u6027\u80bf\u7624\u7684\u9632\u5fa1\u3002CTLs\u3001NK\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548cDCs\u662f\u80bf\u7624\u68c0\u6d4b\u548c\u6e05\u9664\u7684\u4e3b\u8981\u6548\u5e94\u7ec6\u80de\u3002\u5c3d\u7ba1\u80bf\u7624\u7ec6\u80de\u4f1a\u5f62\u6210\u4e00\u79cd\u4e25\u9177\u7684TME\uff0c\u4f46\u8fd9\u4e9b\u6548\u5e94\u514d\u75ab\u7ec6\u80de\u4ecd\u4f1a\u627e\u5230\u65b0\u7684\u751f\u5b58\u65b9\u5f0f\uff0c\u5e76\u4f7f\u7528\u8102\u8d28\u4f5c\u4e3a\u652f\u6301\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u71c3\u6599\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u5728\u6297\u539f\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">CD8<sup style=\"font-size: 12px;box-sizing: border-box;\"><span style=\"box-sizing: border-box;\">+<\/span><\/sup> T\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u9002\u5e94\u6027\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u6700\u91cd\u8981\u7684\u6267\u884c\u8005\u3002\u80bf\u7624\u7279\u5f02\u6027MHC\u9650\u5236\u6027CTLs\u53ef\u4ee5\u5728\u4e0d\u5f71\u54cd\u6b63\u5e38\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\u6eb6\u89e3\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">FAs\u4f5c\u4e3aT\u7ec6\u80de\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7FAO\u548c\u78f7\u9178\u5316\u4e3aT\u7ec6\u80de\u63d0\u4f9b\u80fd\u91cf\u3002TME\u4e2d\u589e\u52a0\u7684FAs\u6fc0\u6d3bCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4e2d\u7684PPAR\u03b1\u4fe1\u53f7\uff0c\u4fc3\u8fdb\u5176\u8102\u8d28\u4ee3\u8c22\u5e76\u7ef4\u6301\u6548\u5e94\u529f\u80fd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u4fc3\u8fdb\u80bf\u7624\u81a8\u80c0\u578bCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684FA\u5206\u89e3\u4ee3\u8c22\u53ef\u63d0\u9ad8\u5176\u6297\u80bf\u7624\u6d3b\u6027\u3002PPAR-\u03b3\u662f\u8102\u8d28\u4ee3\u8c22\u4e2d\u7684\u4e00\u79cd\u5173\u952e\u7684\u914d\u4f53\u8bf1\u5bfc\u6838\u53d7\u4f53\uff0c\u6fc0\u6d3bPPAR-\u03b3\u53ef\u4ee5\u901a\u8fc7\u4e0a\u8c03FAO\u548c\u6291\u5236Tefs\u7684\u51cb\u4ea1\uff0c\u6765\u4fc3\u8fdb\u5929\u7136T\u7ec6\u80de\u5411\u6548\u5e94T\u7ec6\u80de(Tefs)\u7684\u5206\u5316\u3002\u5e76\u4e14\uff0cCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u589e\u52a0\u4e86\u5f15\u6d41\u6dcb\u5df4\u7ed3\u548c\u80bf\u7624\u90e8\u4f4d\u4e2d\u6548\u5e94\/\u8bb0\u5fc6\u6027CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u6d3b\u6027(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">F<\/span><span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">ig.&nbsp;2a<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4e2d\u8102\u8d28\u7684\u6d88\u8017\u80fd\u591f\u963b\u788d\u5176\u589e\u6b96\u548c\u7ec6\u80de\u6bd2\u6027\uff0c\u5bfc\u81f4\u529f\u80fd\u8870\u7aed\uff0c\u5176\u7279\u5f81\u662f\u5e72\u6270\u7d20(IFN)-\u03b3\u548c\u9ad8\u5ea6\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d-1 (PD-1)\u8868\u8fbe\u51cf\u5c11\u3002PD-1\u4fe1\u53f7\u901a\u8def\u6291\u5236TCR-\u548cCD28\u4ecb\u5bfc\u7684PI3K\/AKT\/ mTOR\u901a\u8def\u7684\u6fc0\u6d3b\uff0c\u8fdb\u800c\u4fc3\u8fdb\u8102\u80aa\u5206\u89e3\u548cFAO\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6709\u62a5\u9053\u79f0\uff0c\u6297PD -1\u6297\u4f53\u7684\u5e94\u7528\u6291\u5236\u4e86T\u7ec6\u80de\u7684FAO\u6c34\u5e73\uff0c\u5e76\u5bfc\u81f4T\u7ec6\u80de\u8fc7\u5ea6\u6fc0\u6d3b\u800c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5c06FAO\u6fc0\u6d3b\u56e0\u5b50\u4e0e\u6297PD -1\u6297\u4f53\u7ed3\u5408\u53ef\u4ee5\u9006\u8f6cFAO\u6c34\u5e73\u7684\u6291\u5236\u53ca\u5176\u5bf9T\u7ec6\u80de\u5206\u5316\u7684\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e00\u79cdpan-PPAR\u53d7\u4f53\u6fc0\u52a8\u5242Bezaf brate\u53ef\u63d0\u9ad8PD-1\u963b\u65ad\u4e0b\u7684FAO\u6c34\u5e73\uff0c\u63d0\u9ad8CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6297\u80bf\u7624\u80fd\u529b\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cPPAR-\u03b1\u57fa\u56e0\u6572\u9664\u4f1a\u635f\u5bb3\u4f34\u6709PD-1\u8868\u8fbe\u7684CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684FA\u5206\u89e3\u4ee3\u8c22\u548c\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9664Tefs\u5916\uff0c\u80bf\u7624\u81a8\u80c0\u578bCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> Trm T\u7ec6\u80de\u8fd8\u901a\u8fc7\u91ca\u653e\u6eb6\u89e3\u9897\u7c92\u3001\u9897\u7c92\u9176B (GzmB)\u3001IFN-\u03b3\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50(TNF)-\u03b1\u8868\u73b0\u51fa\u6297\u80bf\u7624\u6d3b\u6027(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 2a<\/span>)\u3002CD36\u4ecb\u5bfc\u7684\u7ec6\u80de\u95f4\u9ad8FA\u6c34\u5e73\u6709\u52a9\u4e8e\u7ef4\u6301CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+ <\/sup>Trm\u7ec6\u80de\u7684\u6709\u6548\u529f\u80fd\u548c\u957f\u671f\u751f\u5b58\uff0c\u9006\u8f6c\u7531\u764c\u7ec6\u80de\u5f15\u8d77\u7684\u8102\u8d28\u5265\u593a\u6240\u81f4\u7684\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531 (programmed death-ligand 1, PD-L1)\u5835\u585e\u53ef\u589e\u52a04\/5\u7684\u8102\u80aa\u9178\u7ed3\u5408\u86cb\u767d(FABP) \u7684\u8868\u8fbe\u548c\u5bf9\u8102\u8d28\u6444\u53d6\uff0c\u5ef6\u957fTrm\u7ec6\u80de\u5728\u4f53\u5916\u548c\u4f53\u5185\u7684\u751f\u5b58\u671f\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd9\u4e9b\u7ed3\u679c\u63d0\u793aFA\u4ee3\u8c22\u548cT\u7ec6\u80de\u6297\u80bf\u7624\u4f5c\u7528\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u7684\u6f5c\u5728\u8054\u7cfb\uff0c\u7279\u522b\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u65b9\u9762\u3002\u589e\u5f3aCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4e2d\u7684FAO\u53ef\u4ee5\u589e\u5f3a\u5176\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u5c24\u5176\u662f\u4e0e\u6297PD -1\u6cbb\u7597\u8054\u5408\u4f7f\u7528\u65f6\u3002\u56e0\u6b64\uff0cFA\u4ee3\u8c22\u81f3\u5c11\u90e8\u5206\u589e\u5f3a\u4e86T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u8fd9\u610f\u5473\u7740\u523a\u6fc0T\u7ec6\u80deFA\u6444\u53d6\u548c\u589e\u5f3aFAO\u53ef\u80fd\u662f\u4e00\u79cd\u53ef\u4ee5\u8fd0\u7528\u4e8e\u6cbb\u7597\u6076\u6027\u80bf\u7624\u7684\u65b9\u6cd5\u3002\u6240\u4ee5\uff0c\u6076\u6027\u80bf\u7624\u7684\u4e34\u5e8a\u6cbb\u7597\u5e94\u7ed3\u5408T\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7684\u5e72\u9884\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u5047\u8bbe\uff0c\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u63a2\u7d22\u4e86FAs\u5728\u5d4c\u5408\u6297\u539f\u53d7\u4f53(CAR) T\u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u662f\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u6027\u6076\u6027\u80bf\u7624\u7684\u4e00\u79cd\u6709\u6548\u9009\u62e9\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">4-1BB CAR-T\u7ec6\u80de\u4fc3\u8fdbCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup>\u4e2d\u592e\u8bb0\u5fc6T\u7ec6\u80de\u7684\u751f\u957f\uff0c\u8be5\u7ec6\u80de\u4ee5FAs\u4e3a\u4e3b\u8981\u80fd\u91cf\u6765\u6e90\uff0c\u5e7f\u6cdb\u4f9d\u8d56\u4e8eFAO\u3002\u4e0eCD28 CAR- T\u7ec6\u80de\u76f8\u6bd4\uff0cCAR\u67b6\u6784\u4e2d\u76844-1BB\u5bfc\u81f4\u4e86\u66f4\u9ad8\u7684FAO\u3001\u547c\u5438\u80fd\u529b\u548c\u751f\u957f\u901f\u7387\uff0cCD28 CAR- T\u7ec6\u80de\u7684\u7279\u5f81\u662f\u9ad8\u7cd6\u9175\u89e3\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cCAR-T\u7ec6\u80de\u4e2dFA\u4ee3\u8c22\u7684\u6539\u53d8\u53ef\u4ee5\u5f71\u54cd\u5b83\u4eec\u7684\u751f\u5b58\u3001\u529f\u80fd\u548c\u6ce8\u5c04\u540e\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u8fd9\u4e3a\u6211\u4eec\u63d0\u793a\u4e86\u4e00\u4e2a\u5f88\u6709\u524d\u666f\u7684T\u7ec6\u80de\u6cbb\u7597\u65b9\u5411\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u80c6\u56fa\u9187\u662fT\u7ec6\u80de\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u53e6\u4e00\u4e2a\u5173\u952e\u8c03\u8282\u56e0\u5b50\u3002T\u7ec6\u80de\u819c\u4e2d\u7684\u6e38\u79bb\u80c6\u56fa\u9187\u662fT\u7ec6\u80de\u53d7\u4f53(TCRs)\u548cT\u7ec6\u80de\u514d\u75ab\u7a81\u89e6\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u76f4\u63a5\u8c03\u8282\u4fe1\u53f7\u901a\u8def\u548c\u6548\u5e94\u5668\u529f\u80fd(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 2a<\/span>)\u3002ACAT1\/2\u6291\u5236\u5242\u963b\u65ad\u80c6\u56fa\u9187\u916f\u5316\u4f5c\u7528\u5bfc\u81f4\u80c6\u56fa\u9187\u6c34\u5e73\u5347\u9ad8\uff0c\u4fc3\u8fdbTCR\u5fae\u7c07\u76f4\u63a5\u5411\u7a81\u89e6\u4e2d\u5fc3\u79fb\u52a8\uff0c\u540c\u65f6CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+ <\/sup>T\u7ec6\u80de\u6570\u91cf\u548c\u6297\u80bf\u7624\u6d3b\u6027\u5747\u5347\u9ad8\u3002\u540c\u65f6\uff0c\u5728ACAT1\u6291\u5236CD19-CAR-T\u7ec6\u80de\u5904\u4e8e\u4f4e\u611f\u67d3\u7387\u7684\u60c5\u51b5\u4e0b\uff0c\u901a\u8fc7\u63d0\u9ad8\u6548\u5e94\u9776\u7ec6\u80de\u6bd4\u4f8b\uff0c\u589e\u5f3a\u4e86CD19-CAR-T\u7ec6\u80de\u7684\u9650\u7624\u6d3b\u6027\uff0c\u5e76\u53ef\u5728\u5316\u7597\u514d\u75ab\u6cbb\u7597\u4e2d\u62ee\u6297CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u6291\u5236\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u81ea\u7136\u6740\u4f24T\u7ec6\u80de(natural killer T, NKT)\u7ec6\u80de\u662f\u4e00\u7fa4CD1d\u9650\u5236\u6027T\u7ec6\u80de\uff0c\u540c\u65f6\u5177\u6709\u9002\u5e94\u6027\u548c\u5148\u5929\u514d\u75ab\u7ec6\u80de\u7684\u7279\u5f81\uff0c\u4e3b\u8981\u529f\u80fd\u662f\u8bc6\u522b\u8102\u8d28\u6297\u539f\uff0c\u53d1\u6325\u591a\u79cd\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u8102\u8d28\u53ef\u4ee5\u8c03\u8282NKT\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u80bf\u7624\u7ec6\u80de\u7684\u8fc7\u5ea6\u7cd6\u9175\u89e3\u5bfc\u81f4TME\u4e2d\u4ea7\u751f\u5927\u91cf\u7684\u4e73\u9178\uff0c\u4ece\u800c\u964d\u4f4e\u80bf\u7624\u81a8\u80c0\u4e0d\u53d8NKT\u7ec6\u80de(iNKT)\u4e2dPPAR-\u03b3\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u8fdb\u800c\u51cf\u5c11\u8102\u8d28\u5408\u6210\u548cIFN-\u03b3\u7684\u4ea7\u751f\u3002PPAR-\u03b3\u6fc0\u6d3b\u5242\u9006\u8f6c\u4e86\u8fd9\u4e00\u73b0\u8c61\uff0c\u589e\u5f3a\u4e86iNKT\u7684\u6297\u80bf\u7624\u6d3b\u6027(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 2c<\/span><span style=\"box-sizing: border-box;\">)\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c\u53ea\u6709\u6c34\u6eb6\u6027\u80c6\u56fa\u9187\uff0c\u800c\u4e0d\u662f\u5176\u4ed6\u7c7b\u578b\u7684\u8102\u8d28\uff0c\u80fd\u591f\u6210\u529f\u6062\u590dIFN-\u03b3\u7684\u4ea7\u751f\uff0c\u5e76\u589e\u5f3aiNKT\u7ec6\u80de\u514d\u75ab\u7a81\u89e6\u7684TCR\u4fe1\u53f7\u3002\u8f9b\u4f10\u4ed6\u6c40\u6291\u5236\u80c6\u56fa\u9187\u5408\u6210\u663e\u8457\u524a\u5f31\u4e86\u8fd9\u79cd\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"1.0907407\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-8257dd62618c47ac1c0e1d39ca75b9fa.png\"  \/><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: justify;white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 2<\/span>&nbsp;&nbsp;<span style=\"box-sizing: border-box;\">\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u8102\u8d28\u4ee3\u8c22\u3002Trms\u901a\u8fc7CD36\u548cFATPs\u4eceTME\u4e2d\u5438\u6536FAs\uff0c\u4ea7\u751f\u6297\u80bf\u7624\u7ec6\u80de\u56e0\u5b50\u5982GzmB, IFN-\u03b3\u548cTNF-\u03b1\u3002\u6b64\u5916\uff0c\u80c6\u56fa\u9187\u6709\u52a9\u4e8eTefs\u4e0atcr\u7684\u5f62\u6210\uff0c\u5e76\u523a\u6fc0\u5176\u589e\u6b96\u548c\u7ec6\u80de\u6bd2\u6027\u3002PPAR-\u03b1\/\u03b3\u4e5f\u53ef\u901a\u8fc7\u6fc0\u6d3bFAO\u589e\u5f3aTefs\u7684\u6297\u80bf\u7624\u80fd\u529b;b TME\u4e2d\u7684FAs\u589e\u5f3a\u5de8\u566c\u7ec6\u80de\u4e2d\u7684FAO\uff0c\u4ece\u800c\u4e0a\u8c03ROS\u7684\u4ea7\u751f\uff0c\u4e0b\u8c03IL-10\u7684\u5206\u6ccc\uff0c\u6d88\u9664\u80bf\u7624\u7ec6\u80de\u3002\u5de8\u566c\u7ec6\u80deE-FABPs\u6c34\u5e73\u5347\u9ad8\u53ef\u4fc3\u8fdbIFN-\u03b2\u8868\u8fbe\uff0c\u4ecb\u5bfcNK\u7ec6\u80de\u62db\u52df\u6740\u4f24\u80bf\u7624\u7ec6\u80de;c\u901a\u8fc7LDLR\u6444\u5165\u7684\u80c6\u56fa\u9187\u523a\u6fc0\u6548\u5e94\u6807\u8bb0\u7269(GzmB\u548c\u7a7f\u5b54\u7d20)\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u7684\u8868\u8fbe\u3002NK\u7ec6\u80de\u6fc0\u6d3bPPAR-\u03b3\u4fc3\u8fdbIFN-\u03b3\u5206\u6ccc\uff0cTME\u4e2d\u8fc7\u91cf\u4e73\u9178\u6291\u5236IFN-\u03b3\u5206\u6ccc;d\u7518\u6cb9\u4e09\u916f\u548c\u78f7\u8102\u589e\u5f3a\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u4ea4\u53c9\u8868\u8fbe\u80fd\u529b\u548c\u7ec6\u80de\u56e0\u5b50\u5206\u6ccc\u6c34\u5e73\uff0c\u53c2\u4e0e\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u4fc3\u8fdb\u975e\u7279\u5f02\u6027\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">FAs\u548c\u80c6\u56fa\u9187\u4f5c\u4e3a\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u7684\u71c3\u6599\u548c\u7ed3\u6784\u6210\u5206\uff0c\u4fc3\u8fdb\u6297\u539f\u7279\u5f02\u6027\u68c0\u6d4b\u548c\u80bf\u7624\u7ec6\u80de\u7684\u6e05\u9664\u3002\u4e0eNKT\u7ec6\u80de\u4e0d\u540c\uff0cNK\u7ec6\u80de\u8bf1\u5bfc\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u662f\u975e\u7279\u5f02\u6027\u7684\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">NK\u7ec6\u80de\u4e3b\u8981\u7684\u6297\u80bf\u7624\u673a\u5236\u5305\u62ec\u6548\u5e94\u7269\u5bf9\u9776\u70b9\u7684\u8bc6\u522b\u548c\u5076\u8054\u3001\u6b7b\u4ea1\u4fe1\u53f7\u7684\u4f20\u9012\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u7684\u5d29\u89e3\u3002\u80c6\u56fa\u9187\u80fd\u589e\u5f3aNK\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u9ad8\u80c6\u56fa\u9187\u996e\u98df\u53ef\u589e\u52a0NK\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u5e76\u4e0a\u8c03NK\u7ec6\u80de\u4e2d\u6fc0\u6d3b\u53d7\u4f53\u548c\u6548\u5e94\u86cb\u767d\u7684\u6c34\u5e73\uff0c\u5982GzmB\u548c\u7a7f\u5b54\u7d20\u3002LDLR\u4ecb\u5bfcNK\u7ec6\u80de\u4e2d\u80c6\u56fa\u9187\u7684\u79ef\u7d2f\uff0c\u4f1a\u523a\u6fc0\u514d\u75ab\u6fc0\u6d3b\u80fd\u529b\uff0c\u964d\u4f4e\u80bf\u7624\u589e\u6b96\uff08<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;2c<\/span>)\u3002\u5728\u80bf\u7624\u6d78\u6da6\u7684NK\u7ec6\u80de\u4e2d\u7279\u5f02\u6027\u8868\u8fbeLDLR\u53ef\u80fd\u662f\u52a8\u5458NK\u7ec6\u80de\u4ea7\u751f\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u6700\u4f73\u65b9\u6cd5\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u56e0\u6b64\uff0c\u80c6\u56fa\u9187\u5728NK\u7ec6\u80de\u4e2d\u7684\u79ef\u7d2f\u53ef\u80fd\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u65b9\u6cd5\uff0c\u53ef\u4ee5\u5728\u514d\u75ab\u6291\u5236TME\u4e2d\u5524\u9192\u5b83\u4eec\u7684\u6297\u80bf\u7624\u80fd\u529b\uff0c\u5e76\u5355\u72ec\u6216\u534f\u540c\u53d1\u6325\u80bf\u7624\u6d88\u9664\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728TME\u4e2d\uff0c\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u4e3b\u8981\u901a\u8fc7\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u53ef\u6eb6\u6027\u7ec6\u80de\u6bd2\u6027\u56e0\u5b50\u53d1\u6325\u6297\u539f\u5448\u9012\u4f5c\u7528\uff0c\u5e76\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u3002\u6709\u62a5\u9053\u79f0\uff0c\u80a5\u80d6\u4f1a\u79ef\u805a\u4fc3\u708e\u5de8\u566c\u7ec6\u80de\uff0c\u5e76\u5bfc\u81f4\u6d3b\u6027\u6c27(ROS)\u6c34\u5e73\u5347\u9ad8<span style=\"box-sizing: border-box;\">(<\/span><span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;2b<\/span><span style=\"box-sizing: border-box;\">)\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7136\u800c\uff0c\u8fd9\u79cd\u73b0\u8c61\u5e76\u4e0d\u666e\u904d\uff0c\u4e0eFA\u4e9a\u578b\u6709\u5f88\u5927\u5173\u7cfb\u3002\u4f8b\u5982\uff0c\u4e0e\u6930\u5b50\u6cb9\u5582\u517b\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u9c7c\u6cb9\u5582\u517b\u7684\u5c0f\u9f20\u80bf\u7624\u524d\u5de8\u566c\u7ec6\u80de\u548c\u767d\u4ecb\u7d20(IL-10)\u7684\u8868\u8fbe\u6bd4\u4f8b\u8f83\u4f4e\uff0cB\u7ec6\u80de\u548cCD<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> 8 T\u7ec6\u80de\u7684\u6d78\u6da6\u7387\u8f83\u9ad8\u3002\u6b64\u5916\uff0c\u591a\u4e0d\u9971\u548c\u8102\u80aa\u9178(PUSFAs)\u800c\u975e\u9971\u548c\u8102\u80aa\u9178(SFAs)\u7684\u5bcc\u96c6\u5bf9\u5de8\u566c\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u5177\u6709\u66f4\u9ad8\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd9\u5c31\u4ea7\u751f\u4e86\u4e00\u79cd\u5047\u8bbe\uff0c\u5373\u4e00\u4e9bFAs\u53ef\u80fd\u589e\u5f3a\u5de8\u566c\u7ec6\u80de\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u800c\u53e6\u4e00\u4e9b\u5219\u6ca1\u6709\u3002\u9c7c\u6cb9\u4e2d\u7684\u4e00\u79cd\u4e0d\u9971\u548c\u8102\u80aa\u9178N-3 docosapentaenoic acid\u7279\u5f02\u6027\u5730\u589e\u52a0\u4e86\u7cae\u519c\u7ec4\u7ec7\u76f8\u5173\u57fa\u56e0(A-FABP\u3001Cpt1b\u3001PCX\u548cUCP2)\u548c\u51cb\u4ea1\u76f8\u5173\u57fa\u56e0(iNOS\u3001RIPK3\u3001caspase-8\u548ccaspase-11)\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u8bf1\u5bfcROS\u4ecb\u5bfc\u7684\u5de8\u566c\u7ec6\u80de\u51cb\u4ea1\uff0c\u964d\u4f4e\u4e86\u4fc3\u80bf\u7624\u6d3b\u6027\u3002\u9ad8\u8868\u8fbeE-FABP\u7684\u5de8\u566c\u7ec6\u80de\u589e\u52a0\u4e86IFN-\u03b2\u7684\u4ea7\u751f\uff0c\u62db\u52df\u4e86\u66f4\u591a\u7684\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\uff0c\u5c24\u5176\u662fNK\u7ec6\u80de(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;2b<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u9176\u5f15\u5bfc\u7684\u78f7\u9178\u916a\u6c28\u9178\u80c6\u56fa\u9187\u7684\u81ea\u7ec4\u88c5\u901a\u8fc7\u8bf1\u5bfcROS\u7684\u4ea7\u751f\uff0c\u7834\u574f\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u6e38\u79bb\u5206\u5b50\uff0c\u6291\u5236\u5375\u5de2\u764c\u7ec6\u80de\u7684\u751f\u957f\uff0c\u4f7f\u524d\u80bf\u7624\u5de8\u566c\u7ec6\u80de\u91cd\u65b0\u5206\u5316\u4e3a\u6297\u80bf\u7624\u8868\u578b\u3002\u8fd9\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u7684\u65b9\u6cd5\uff0c\u901a\u8fc7\u63d0\u4f9b\u5916\u6e90\u6027\u4fee\u9970\u8102\u8d28\uff0c\u4f7f\u80bf\u7624\u6d78\u6da6\u7684\u5de8\u566c\u7ec6\u80de\u6781\u5316\u751a\u81f3\u91cd\u65b0\u57f9\u517b\u4e3a\u6297\u80bf\u7624\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u4e0d\u540c\uff0c\u8102\u8d28\u7c7b\u578b(\u9971\u548c\u4e0e\u4e0d\u9971\u548c)\u8f83\u8102\u8d28\u7684\u6570\u91cf\uff0c\u5728\u523a\u6fc0\u6811\u7a81\u72b6\u7ec6\u80de\u5904\u7406\u6297\u539f\u6216\u91ca\u653e\u6297\u80bf\u7624\u7ec6\u80de\u56e0\u5b50\u4e2d\u53d1\u6325\u7740\u66f4\u4e3a\u5173\u952e\u7684\u4f5c\u7528\u3002\u8102\u8d28\u542b\u91cf\u8f83\u9ad8\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u503e\u5411\u4e8e\u79ef\u7d2f\u78f7\u8102\uff0c\u800c\u4e0d\u662f\u80c6\u56fa\u9187\u548c\u80c6\u56fa\u9187\u916f\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e0e\u8102\u8d28\u542b\u91cf\u4f4e\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u6811\u7a81\u72b6\u7ec6\u80de\u5177\u6709\u66f4\u9ad8\u6c34\u5e73\u7684\u6574\u5408\u7d20\u3001\u5171\u523a\u6fc0\u5206\u5b50\u3001\u7cd6\u86cb\u767d\u3001\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u3002\u4f53\u5185\u5b9e\u9a8c\u8868\u660e\uff0c\u8f83\u9ad8\u7684\u8102\u8d28\u542b\u91cf\u4f7f\u6811\u7a81\u72b6\u7ec6\u80de\u5177\u6709\u8f83\u5f3a\u7684\u4ea4\u53c9\u5448\u73b0\u80fd\u529b\uff0c\u80fd\u6709\u6548\u6fc0\u6d3bNK\u548cNKT\u7ec6\u80de\uff0c\u589e\u5f3a\u5185\u6e90\u6027CTL\u3002\u4f4e\u8102\u542b\u91cf\u66f4\u5bb9\u6613\u5f15\u8d77\u80fd\u91cf\u4e0d\u8db3\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd9\u4e9b\u7ed3\u679c\u5728\u514d\u75ab\u9ad8\u8102\u8d28\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u5c0f\u9f20\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5728\u5c0f\u9f20\u813e\u810f\u548c\u809d\u810f\u4e2d\u5747\u51fa\u73b0\u4e86\u5f3a\u52b2\u7684\u9776\u7ec6\u80de\u88c2\u89e3\uff0c\u5e76\u52a0\u901f\u4e86OVA\u9650\u5236\u6027CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> Tefs\u7684\u589e\u6b96\uff0c\u5ef6\u7f13\u4e86\u80bf\u7624\u7684\u53d1\u5c55\uff0c\u4f7f\u75c5\u7076\u53d8\u5c0f\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u867d\u7136\u5bf9\u4e8eDC\u4e2d\u8102\u8d28\u7684\u7814\u7a76\u8fd8\u5f88\u6709\u9650\uff0c\u4f46\u53ef\u4ee5\u770b\u51faFAs\u53ef\u80fd\u4f5c\u4e3a\u4fc3\u708e\u56e0\u5b50\uff0c\u4ee5DC\u4f9d\u8d56\u7684\u65b9\u5f0f\u589e\u5f3aCTL\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u73b0\u8c61\u662f\u5426\u666e\u904d\u5b58\u5728\u4e8e\u809d\u810f\u4ee5\u5916\u7684\u5176\u4ed6\u7ec4\u7ec7\u548c\u764c\u75c7\u7c7b\u578b\uff0c\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9ad8\u5ea6\u589e\u6b96\u7684\u80bf\u7624\u7ec6\u80de\u5f15\u8d77\u8461\u8404\u7cd6\u7f3a\u4e4f\u548c\u8102\u8d28\u4e30\u5bcc\u7684TME\uff0c\u5df2\u88ab\u8bc1\u660e\u6709\u52a9\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u548c\u4f20\u64ad\uff0c\u5e76\u5bfc\u81f4\u514d\u75ab\u6291\u5236\u73af\u5883\u3002\u4f46\u662f&nbsp;\uff0c\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u8102\u8d28\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u4e0d\u53ef\u6216\u7f3a\u7684\u71c3\u6599\u548c\u4ee3\u8c22\u6210\u5206\uff0c\u4fc3\u8fdb\u514d\u75ab\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u76ee\u524d\u9488\u5bf9\u6076\u6027\u80bf\u7624\u7684\u8102\u8d28\u4ee3\u8c22\u9776\u5411\u6cbb\u7597\u591a\u81f4\u529b\u4e8e\u5355\u7eaf\u963b\u788dTME\u4e2d\u7684\u6cdb\u8102\u8d28\u4ee3\u8c22\uff0c\u6548\u679c\u6709\u9650\u3002\u4f46\u5982\u524d\u6240\u8ff0\uff0c\u67d0\u4e9b\u514d\u75ab\u7ec6\u80de\u7684\u7279\u5f02\u6027\u6fc0\u6d3b\u4ee3\u8c22\u9014\u5f84\u53ef\u663e\u8457\u523a\u6fc0\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4fc3\u8fdb\u6297\u80bf\u7624\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: flex;flex-flow: row nowrap;margin: 20px 0% 10px;justify-content: flex-start;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;box-sizing: border-box;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8102\u8d28\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u867d\u7136\u514d\u75ab\u7cfb\u7edf\u81f4\u529b\u4e8e\u76d1\u89c6\u548c\u6d88\u9664\u8f6c\u5316\u7ec6\u80de\uff0c\u4f46\u4e00\u4e9b\u72e1\u733e\u7684\u80bf\u7624\u7ec6\u80de\u4f1a\u4f2a\u88c5\u81ea\u5df1\uff0c\u5bfc\u81f4\u514d\u75ab\u9003\u9038\u3002\u4e3a\u4e86\u8425\u9020\u9002\u5b9c\u7684\u751f\u957f\u73af\u5883\uff0c\u80bf\u7624\u7ec6\u80de\u5bf9\u5468\u56f4\u7684\u57fa\u8d28\u7ec6\u80de\u8fdb\u884c\u6539\u9020\uff0c\u5c06\u514d\u75ab\u7ec6\u80de\u4ece\u6297\u80bf\u7624\u8868\u578b\u6539\u9020\u4e3a\u65c1\u89c2\u8005\u8868\u578b\uff0c\u751a\u81f3\u662f\u4fc3\u80bf\u7624\u8868\u578b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5982\u524d\u6587\u6240\u8ff0\uff0c\u80bf\u7624\u7ec6\u80de\u4e0e\u514d\u75ab\u7ec6\u80de\u5bf9\u8425\u517b\u7269\u8d28\u7684\u6fc0\u70c8\u7ade\u4e89\uff0c\u6700\u7ec8\u5bfc\u81f4\u5fae\u73af\u5883\u7f3a\u7cd6\u7f3a\u6c27\uff0c\u8102\u8d28\u8fc7\u5ea6\u5806\u79ef\uff0c\u8102\u8d28\u4ee3\u8c22\u6d3b\u8dc3\u3002\u5c3d\u7ba1\u8102\u8d28\u4ee3\u8c22\u6fc0\u6d3b\u4f1a\u5f15\u8d77\u514d\u75ab\u7ec6\u80de\u4e0a\u8ff0\u5bf9\u80bf\u7624\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4f46\u5f02\u5e38\u7684\u8102\u8d28\u72b6\u6001\u4e5f\u4f1a\u6291\u5236\u514d\u75ab\u7ec6\u80de\u7684\u6297\u80bf\u7624\u80fd\u529b\uff0c\u751a\u81f3\u4f7f\u514d\u75ab\u7ec6\u80de\u91cd\u65b0\u5206\u5316\u4e3a\u4fc3\u80bf\u7624\u8868\u578b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd9\u79cd\u4e0d\u4e00\u81f4\u53ef\u80fd\u662f\u7531\u4e8e\u764c\u75c7\u7c7b\u578b\u6216\u8102\u8d28\u79cd\u7c7b\u7684\u5dee\u5f02\u5bfc\u81f4\u7684\u3002\u56e0\u6b64\uff0c\u6df1\u5165\u63a2\u8ba8\u8102\u8d28\u4ee3\u8c22\u548c\u80bf\u7624\u524d\u514d\u75ab\u5e94\u7b54\u5bf9\u4e8e\u5728\u4e0d\u7834\u574f\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u7684\u524d\u63d0\u4e0b\u9006\u8f6c\u514d\u75ab\u6291\u5236TME\u7684\u673a\u5236\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">FAs\u7684\u79ef\u7d2f\u7834\u574f\u4e86\u6548\u5e94T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6700\u8fd1\u7684\u7814\u7a76\u62a5\u544a\uff0c\u539f\u751fT\u7ec6\u80de\u7684\u80fd\u91cf\u4ea7\u751f\u66f4\u591a\u5730\u4f9d\u8d56\u4e8e\u7ebf\u7c92\u4f53\u547c\u5438\u548cFAO\uff0c\u4ee5\u5c3d\u91cf\u51cf\u5c11\u6709\u6bd2\u4ee3\u8c22\u7269\u5bf9\u7ec6\u80de\u7684\u7834\u574f\u4f5c\u7528\u3002\u7136\u800c\uff0c\u4e3a\u4e86\u7ef4\u6301\u8f83\u9ad8\u7684\u589e\u6b96\u901f\u7387\u548c\u6d3b\u6027\uff0cTefs\u503e\u5411\u4e8e\u5229\u7528\u7cd6\u9175\u89e3\u548c\u6709\u6c27\u547c\u5438\u6765\u6ee1\u8db3ATP\u7684\u9700\u6c42\u3002\u8fd9\u610f\u5473\u7740\u5bcc\u542b\u8102\u8d28\u7684TME\u53ef\u80fd\u4f1a\u6291\u5236Tefs\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7531\u4e8e\u7f3a\u5c11\u5173\u952e\u9176\uff0cCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u65e0\u6cd5\u5206\u89e3\u79ef\u7d2f\u7684\u7ec6\u80de\u95f4\u6781\u957f\u94feFAs\u6216\u5c06\u5176\u50a8\u5b58\u5728LDs\u4e2d\uff0c\u56e0\u6b64\u4f1a\u9020\u6210\u4e25\u91cd\u7684\u8102\u80aa\u6bd2\u6027\uff0c\u8fdb\u800c\u5bfc\u81f4T\u7ec6\u80de\u8870\u7aed\u3002\u5bcc\u542b\u8102\u8d28\u7684\u4eba\u4e73\u817a\u764c\u7ec4\u7ec7\u91ca\u653e\u5927\u91cfFFA\u4ee5\u6291\u5236CTL\u4ecb\u5bfc\u7684\u80bf\u7624\u6291\u5236\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u964d\u4f4eFFA\u6c34\u5e73\u6765\u9006\u8f6c(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3a<\/span>)\u3002\u4ecb\u5bfcFAs\u7684\u80fd\u529b\u964d\u4f4e\u4f1a\u4f7fCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u65e0\u6cd5\u7ef4\u6301\u8102\u8d28\u7a33\u6001\u5e76\u964d\u4f4e\u5176\u6297\u80bf\u7624\u80fd\u529b\u3002\u800cTefs\u7ec6\u80de\u4e2d\u79ef\u7d2f\u7684FAs\u589e\u5f3a\u4e86\u968f\u540e\u7684\u5206\u89e3\u4ee3\u8c22\u548cFAO\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u867d\u7136\u53ef\u4ee5\u63a8\u6d4bFAO\u53ef\u4ee5\u63d0\u9ad8PD-1\u6297\u4f53\u6cbb\u7597\u65f6CD8+ T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4f46\u7ed3\u679c\u5374\u4e0e\u6b64\u76f8\u53cd\u3002\u6709\u62a5\u9053\u79f0STAT3\u901a\u8fc7\u4fc3\u8fdbFAO\u548c\u51cf\u5c11\u7cd6\u9175\u89e3\u6765\u6291\u5236CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> Tefs\u7ec6\u80de\u3002\u5728T\u7ec6\u80de\u4e2d\u6572\u9664Stat3\u6216\u4f7f\u7528FAO\u6291\u5236\u5242\u53ef\u4ee5\u589e\u5f3a\u7cd6\u9175\u89e3\u548c\u6297\u80bf\u7624\u529f\u80fd\uff0c\u4ece\u800c\u6d88\u9664\u4e73\u817a\u80bf\u7624\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6709\u62a5\u9053\u79f0\uff0c\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u662f\u901a\u8fc7\u4e0e\u7626\u7d20\u53d7\u4f53\u6216CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684PD-1\u7ed3\u5408\uff0c\u523a\u6fc0STAT3\u548cCPT1B\uff0c\u6291\u5236\u5176\u7cd6\u9175\u89e3\u548c\u6297\u80bf\u7624\u80fd\u529b\uff0c\u800c\u7626\u7d20(leptin)\u662f\u8102\u80aa\u7ec6\u80de\u5206\u6ccc\u7684\u4e00\u79cd\u8102\u80aa\u56e0\u5b50(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3a<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0cPD-1\u7684\u6fc0\u6d3b\u6539\u53d8\u4e86\u9884\u5148\u6fc0\u6d3b\u7684CD4<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684\u4ee3\u8c22\u7a0b\u5e8f\uff0c\u4ece\u7cd6\u9175\u89e3\u8f6c\u5316\u4e3aFAO\u3002\u8fd9\u4e9b\u673a\u5236\u53ef\u80fd\u89e3\u91ca\u4e86PD-1\u523a\u6fc0\u7684T\u7ec6\u80de\u514d\u75ab\u8010\u53d7\u7684\u539f\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">Tc9\u7ec6\u80de\u662f\u9ad8\u8868\u8fbeIL-9\u7684CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4e9a\u7fa4\uff0c\u5177\u6709\u6bd4Tc1\u7ec6\u80de\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u80fd\u529b\u3002\u82af\u7247\u5206\u6790\u663e\u793a\uff0cTc9\u7ec6\u80dePPAR-\u03b1\/\u7c7b\u7ef4\u751f\u7d20a X\u53d7\u4f53\u03b1\u6c34\u5e73\u8f83\u4f4e\uff0c\u80c6\u56fa\u9187\u5408\u6210\u9176(Hmgcr\u548cSqle)\u8868\u8fbe\u8f83\u4f4e\uff0c\u80c6\u56fa\u9187\u6d41\u51fa\u9176(Abca\u548cAbcg1)\u8868\u8fbe\u8f83\u9ad8\u3002\u80c6\u753e\u9187\u7684\u52a0\u5165\u53ef\u6291\u5236IL-9\u7684\u8868\u8fbe\uff0c\u8bf1\u5bfcTc9\u7ec6\u80de\u51cb\u4ea1\uff0c\u5bfc\u81f4\u6297\u80bf\u7624\u6d3b\u6027\u53d7\u635f\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9664\u4e86\u5f71\u54cd\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u80c6\u56fa\u9187\u8fd8\u4f1a\u5bfc\u81f4\u80bf\u7624\u6d78\u6da6\u6027CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+ <\/sup>T\u7ec6\u80de\u7684\u8870\u7aed(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3a<\/span>)\u3002\u4f53\u5916\u5b9e\u9a8c\u548c\u4e34\u5e8a\u6837\u672c\u663e\u793a\uff0c\u80c6\u56fa\u9187\u53ef\u589e\u52a0CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684PD-1\u548c2B4\u7684\u8868\u8fbe\uff0c\u4e14\u5448\u5242\u91cf\u4f9d\u8d56\u6027\uff0c\u4e0e\u7ec6\u80de\u51cb\u4ea1\u7387\u76f8\u5173\u3002\u800cCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4e2dGzmB\u3001IFN-\u03b3\u548cTNF-\u03b1\u7684\u589e\u6b96\u7387\u548c\u4ea7\u91cf\u5747\u4e0b\u964d\u3002\u8fd9\u4e00\u73b0\u8c61\u7684\u53ef\u80fd\u673a\u5236\u81f3\u5c11\u6709\u90e8\u5206\u53ef\u80fd\u662f\u4f9d\u8d56\u4e8eX-box\u7ed3\u5408\u86cb\u767d1\u7684\u5347\u9ad8\u548c\u5185\u8d28\u7f51\u5e94\u6fc0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8c03\u8282\u6027T\u7ec6\u80de\u9700\u8981FAs\u6765\u53d1\u6325\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">Tregs\u662f\u4e00\u7ec4\u80bf\u7624\u6d78\u6da6\u6027\u514d\u75ab\u6291\u5236CD4<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\uff0c\u4e3b\u8981\u4f9d\u8d56\u4e8eFAO\u800c\u4e0d\u662f\u7cd6\u9175\u89e3\u3002\u8fd9\u4e9b\u7279\u5f81\u4f7f\u5b83\u4eec\u80fd\u591f\u5728\u8425\u517b\u8017\u5c3d\u7684TME\u4e2d\u751f\u5b58\u5e76\u8868\u73b0\u51fa\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u7f3a\u6c27TME\u4e2d\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50-1\u03b1\u5f15\u5bfc\u8461\u8404\u7cd6\u8fdc\u79bb\u7ebf\u7c92\u4f53\uff0c\u4fc3\u8fdbTregs\u4e2d\u7684\u7ebf\u7c92\u4f53\u4ee3\u8c22\uff0c\u589e\u5f3a\u5176\u6291\u5236CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684\u80fd\u529b\u3002\u53c9\u5934\u76d2\u86cb\u767dP3 (Forkhead box protein P3, FoxP3)\u53ef\u4fc3\u8fdbTregs\u4e2d\u7684FA\u6444\u53d6\u3001\u6c27\u5316\u78f7\u9178\u5316\u548cFAO\uff0c\u5e76\u5e2e\u52a9\u5b83\u4eec\u5728\u8102\u6bd2\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u751f\u5b58\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u514d\u75ab\u9003\u9038\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u9ad8\u4e73\u9178\u5fae\u73af\u5883\u4e2d\uff0cTregs\u4e0aCD36\u548cFoxP3\u8868\u8fbe\u6c34\u5e73\u5347\u9ad8\uff0c\u901a\u8fc7PPAR-\u03b2\u4f9d\u8d56\u7684\u65b9\u5f0f\u589e\u5f3aFA\u5438\u6536\u548cFAO\uff0c\u4ece\u800c\u589e\u5f3aTregs\u7684\u8102\u6bd2\u6297\u6027\u548c\u4ee3\u8c22\u9002\u5e94\u6027(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3a<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">CD36\u7684\u6d88\u878d\u4e25\u91cd\u964d\u4f4e\u4e86Tregs\u7684\u8102\u8d28\u6444\u53d6\uff0c\u5bfc\u81f4\u80bf\u7624\u751f\u957f\u51cf\u901f\u3002PD-1\u901a\u8fc7\u589e\u5f3aATGL\u3001\u4e0a\u8c03CPT1A\u548cFAO\u6765\u4fc3\u8fdb\u8102\u80aa\u5206\u89e3\u3002\u800c\u6297CD36\u548c\u6297PD -1\u8054\u5408\u6cbb\u7597\u6709\u534f\u540c\u4f5c\u7528\uff0c\u8fd9\u8868\u660eCD36\u963b\u65ad\u53ef\u80fd\u662f\u5f53\u524d\u514d\u75ab\u7597\u6cd5\u7684\u4e00\u79cd\u6709\u6548\u7684\u589e\u5f3a\u5242\uff0c\u5e76\u6709\u51cf\u5c11\u6cbb\u7597\u526f\u4f5c\u7528\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8003\u8651\u5230\u80bf\u7624\u6d78\u6da6Tregs\u7684\u4ee3\u8c22\u7279\u5f81\uff0c\u7814\u7a76\u8005\u8ba4\u4e3aFA\u5408\u6210\u53ef\u80fd\u6bd4FA\u6444\u53d6\u5728\u5f62\u6210\u8102\u8d28Tregs\u6c60\u548c\u4fc3\u8fdb\u5176\u589e\u6b96\u65b9\u9762\u66f4\u91cd\u8981\u3002OX40\u662f\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53\u8d85\u5bb6\u65cf\u6210\u54584\uff0c\u5b83\u901a\u8fc7\u4fc3\u8fdbFA\u5408\u6210\uff0c\u800c\u4e0d\u662fFA\u6444\u53d6\u6765\u5851\u9020Tregs\u7684\u8102\u8d28\u6784\u6210\u5e76\u4fc3\u8fdb\u5176\u589e\u6b96\u3002\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u548c\u4e34\u5e8a\u6570\u636e\u8bc1\u5b9e\uff0c\u6fc0\u6d3b\u753e\u9187\u8c03\u8282\u5143\u4ef6\u7ed3\u5408\u86cb\u767d\u53ef\u4fc3\u8fdb\u8102\u8d28\u5408\u6210\u5e76\u652f\u6301TME\u4e2dOX40<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> Tregs\u7684\u5c40\u90e8\u589e\u6b96\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7203704\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-9f6f3010289356882ee73b9cdc367864.png\"  \/><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"text-align: justify;white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig 3<\/span>&nbsp;&nbsp;<span style=\"box-sizing: border-box;\">\u80bf\u7624\u524d\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u8102\u8d28\u4ee3\u8c22\u3002\u901a\u8fc7CD36\u6216FATPs\u5438\u6536\u7684FAs\u901a\u8fc7\u8bf1\u5bfcTefs\u8017\u5c3d\u6216\u523a\u6fc0treg\u4e2d\u7684PPAR-\u03b2\u548cFAO\u4ecb\u5bfc\u514d\u75ab\u6291\u5236\u53cd\u5e94\u3002FoxP3\u8fd8\u901a\u8fc7\u8c03\u8282treg\u4e2d\u7684FAs\u4ee3\u8c22\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u514d\u75ab\u6291\u5236\u4ecb\u8d28\u3002\u80c6\u56fa\u9187\u8bf1\u5bfcPD-1\u548c2B-4\u7684\u8868\u8fbe\uff0c\u5e76\u968f\u540e\u8017\u5c3dTefs\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002TME\u4e2d\u7684Leptin\u901a\u8fc7PD-1-STAT3-CPT1B\u901a\u8def\u6291\u5236Tefs\uff0c\u4ece\u800c\u589e\u5f3aFAO\uff0c\u6d88\u9664\u7ec6\u80de\u6bd2\u6027\u3002b FAs\u901a\u8fc7\u8f6c\u8fd0\u86cb\u767d\u6444\u5165\u6216\u5728\u5de8\u566c\u7ec6\u80de\u5185\u91cd\u65b0\u5408\u6210\u53ef\u523a\u6fc0CPT1B\u548cFAO\uff0c\u4ece\u800c\u589e\u5f3aARG-1\u548cIL-10\u7b49\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u6216\u6291\u5236TNF-\u03b1\u3001IL-6\u548cIL-1\u03b2\u7b49\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\u3002\u6765\u81eaTME\u7684M-CSF\u589e\u5f3aFASN\u8868\u8fbe\u3002\u9ad8\u8868\u8fbeABCG1\u7684\u5de8\u566c\u7ec6\u80de\u5c06\u80c6\u56fa\u9187\u8f6c\u8fd0\u5230\u4f53\u5916\uff0c\u4fc3\u8fdbIL-4\u8868\u8fbe\u548c\u80bf\u7624\u8fdb\u5c55\u3002c MSR1\u548cTGFBR1\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u4e2dFAs\u8f6c\u8fd0\u548cLD\u7684\u5f62\u6210\uff0c\u4ece\u800c\u5f71\u54cd\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6297\u539f\u52a0\u5de5\u3001TLR\u523a\u6fc0\u548c\u589e\u6b96\u3002d MDSCs\u4e0aCD36\u5438\u6536\u7684PUSFAs\u6fc0\u6d3bSTAT3\/5\u5e76\u523a\u6fc0ROS\u7684\u4ea7\u751f\u3002M-CSF\u4fc3\u8fdbMDSCs\u4e2dFASN\u548cFA\u7684\u4ea7\u751f\uff0c\u8fdb\u800c\u589e\u52a0\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u5982IL-10\u3001ARG-1\u548ciNOS\u3002e FAs\u901a\u8fc7mTOR-PPAR\u4fe1\u53f7\u901a\u8def\u6291\u5236NK\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002f\u7531\u4e8e\u5916\u6e90\u6027FAs\u6444\u5165\u589e\u52a0\u548cPGE2\u4e0b\u8c03\u8102\u89e3\u9176ATGL, ld\u5728\u80bf\u7624\u6d78\u6da6\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\u5bcc\u96c6\u3002\u7136\u540e\u5c06\u4e2d\u6027\u7c92\u7ec6\u80de\u7684ld\u8f6c\u79fb\u5230\u80bf\u7624\u7ec6\u80de\uff0c\u4fc3\u8fdb\u5176\u589e\u6b96\u548c\u8fdb\u5c55\u3002\u7f9f\u753e\u9187\u901a\u8fc7\u4e0eCXCR2\u7ed3\u5408\u4fc3\u8fdb\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u8fc1\u79fb\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7ec6\u80de\u95f4FAs\u548c\u80c6\u56fa\u9187\u5bf9TAMs\u548cMDSCs\u6709\u76f8\u53cd\u7684\u4f5c\u7528<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5de8\u566c\u7ec6\u80de\u548cMDSCs\u90fd\u6765\u6e90\u4e8e\u9aa8\u9ad3\uff0c\u5e76\u5411\u80bf\u7624\u7ec4\u7ec7\u8fc1\u79fb\u3002\u56e0\u6b64\uff0c\u8fd9\u4e24\u79cd\u7ec6\u80de\u4e9a\u578b\u8868\u73b0\u51fa\u76f8\u4f3c\u7684\u8102\u8d28\u4ee3\u8c22\u7279\u5f81\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u867d\u7136\u5de8\u566c\u7ec6\u80de\u53c2\u4e0e\u591a\u79cd\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u4f46\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(tumor-associated macrophages, TAMs)\u5728TME\u4e2d\u53d7\u591a\u79cd\u56e0\u7d20\u5f71\u54cd\uff0c\u4f1a\u88ab\u91cd\u65b0\u7f16\u7a0b\u4e3aM2\u8868\u578b\uff0c\u5e76\u53d1\u6325\u4fc3\u80bf\u7624\u4f5c\u7528\u3002M1\u66f4\u5bb9\u6613\u5229\u7528\u7cd6\u9175\u89e3\uff0c\u800cM2\u4e3b\u8981\u4f9d\u8d56\u4e8eFAO\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">TAMs\u503e\u5411\u4e8e\u901a\u8fc7CD36\u4eceTME\u4e2d\u6444\u53d6\u66f4\u591a\u7684\u8102\u8d28\uff0c\u4ee5\u7ef4\u6301\u5176\u4fc3\u7624\u80fd\u529b\u3002\u6b64\u5916\uff0cTAMs\u53ef\u4ee5\u901a\u8fc7\u4e59\u9170\u8f85\u9176a\u7684\u4ece\u5934\u5408\u6210\u6765\u6ee1\u8db3\u5176\u5bf9FA\u7684\u9700\u6c42\u3002\u6765\u81eaLewis\u80ba\u764c\u7684\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u8bf1\u5bfcTAMs\u4e2dFASN\u8868\u8fbe\uff0c\u4ee5ARG1\u548cIL-10\u4f9d\u8d56\u7684\u65b9\u5f0f\u523a\u6fc0\u80bf\u7624\u751f\u957f\u548c\u8840\u7ba1\u751f\u6210(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;3b<\/span>)\u3002FASN\u7684\u6291\u5236\u4f7fTAMs\u4e2dTNF-\u03b1\u3001IL-6\u3001IL-10\u548cROS\u7684\u8868\u8fbe\u88ab\u663e\u8457\u6291\u5236\uff0c\u4ece\u800c\u524a\u5f31\u5176\u4fc3\u80bf\u7624\u6d3b\u6027\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u5f02\u5e38\u7684\u8102\u8d28\u79ef\u7d2f\u662fTAMs\u53c2\u4e0e\u80bf\u7624\u524d\u514d\u75ab\u5e94\u7b54\u7684\u5fc5\u8981\u6761\u4ef6\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u03b1 \/ \u03b2 -\u6c34\u89e3\u9176\u7ed3\u6784\u57df\u86cb\u767d(TAG\u7684\u8102\u89e3\u56e0\u5b50)\u548cMAGL(\u53c8\u79f0MGLL\uff0c\u5355\u9170\u57fa\u7518\u6cb9\u7684\u5173\u952e\u8102\u80aa\u9176)\u662f\u8c03\u8282\u8102\u8d28\u4ee3\u8c22\u5e73\u8861\u7684\u5173\u952e\u9176\u3002MGLL\u8fc7\u8868\u8fbe\u5c0f\u9f20\u6a21\u578b\u4e2dTAMs\u7684\u8102\u8d28\u79ef\u7d2f\u5b8c\u5168\u53d7\u5230\u6291\u5236\uff0c\u540c\u65f6\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50(IL-1\u03b2\u3001TNF-\u03b1\u548cIFN-\u03b3)\u8868\u8fbe\u6c34\u5e73\u5347\u9ad8\uff0c\u6297\u708e\u7ec6\u80de\u56e0\u5b50(IL-10\u3001ARG-1\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2 (TGF-\u03b2)\u548cIL-4)\u8868\u8fbe\u6c34\u5e73\u964d\u4f4e\u3002TGF-\u03b2\u901a\u8fc7\u6fc0\u6d3bMek1\/2\u3001Erk1\/2\u548cRsk1\/2\u4fc3\u8fdbLD\u7684\u5f62\u6210\uff0c\u8fdb\u4e00\u6b65\u589e\u5f3aTAMs\u7684\u514d\u75ab\u6291\u5236\u80fd\u529b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">Mek\u7684\u6291\u5236\u4f5c\u7528\u53ef\u4ee5\u6291\u5236LD\u7684\u5f62\u6210\uff0c\u4fc3\u4f7f\u7ec6\u80de\u56e0\u5b50\u7684\u5e73\u8861\u5411M1\u8868\u578b\u8f6c\u79fb\uff0c\u907f\u514dROS\u548cNO\u6c34\u5e73\u8fc7\u591a\u7684\u964d\u4f4e\u3002\u9700\u8981\u6307\u51fa\u7684\u662f\uff0c\u5728TAMs\u4e2d\uff0cFA\u7684\u5206\u89e3\u4ee3\u8c22\u4e5f\u4f1a\u88ab\u52a0\u5f3a\uff0c\u4ee5\u4ea7\u751f\u66f4\u591a\u7684\u80fd\u91cf\uff0c\u7ef4\u6301\u524d\u80bf\u7624\u8868\u578b\u3002\u5347\u9ad8\u7684CTP1A\u901a\u8fc7\u8c03\u8282JAK1-STAT6\u8f74\u4e0e\u5347\u9ad8\u7684FAO\u3001ATP\u751f\u4ea7\u548c\u6c27\u5316\u5e94\u6fc0\u542f\u52a8\u548c\u5f62\u6210TAMs\u3002\u7528\u4f9d\u6258\u83ab\u897f\u6291\u5236FAO\uff0c\u53ef\u4ee5\u901a\u8fc7\u964d\u4f4eTAMs\u7684\u541e\u566c\u80fd\u529b\u548c\u4e0b\u8c03IL-1\u03b2\u7684\u8868\u8fbe\uff0c\u4ee5ROS-NLRP3\u4f9d\u8d56\u7684\u65b9\u5f0f\u9006\u8f6cTAMs\u7684\u4fc3\u80bf\u7624\u4f5c\u7528(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3b<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u6572\u9664\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u86cb\u767d\u6fc0\u91763\uff0c\u53ef\u901a\u8fc7\u589e\u5f3aFAO\u548c\u6c27\u5316\u78f7\u9178\u5316\u76f8\u5173\u57fa\u56e0(Cpt1a\u3001Cpt1b\u3001Acadvl\u548cHadh)\u6765\u4fc3\u8fdbM2\u8868\u578b\uff0c\u5c24\u5176\u662f\u589e\u5f3a\u5de8\u566c\u7ec6\u80de\u4e2dPD-L1\u7684\u8868\u8fbe\u3002\u8fd9\u63d0\u793a\u6211\u4eecFAs\u5728TAMs\u4e2d\u5177\u6709\u6297\u708e\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">TME\u4e2d\u7684MDSCs\u8868\u73b0\u51fa\u5f3a\u5927\u800c\u5168\u9762\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5b83\u4e0d\u4ec5\u80fd\u901a\u8fc7\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u751f\u957f\u6765\u8868\u73b0\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u8fd8\u80fd\u901a\u8fc7\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u5efa\u7acb\u590d\u6742\u7684\u7f51\u7edc\u6765\u8868\u73b0\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u901a\u8fc7\u8f6c\u8fd0\u53d7\u4f53(Slc27a1\/Fatp1, Slc27a6\/Fatp6, Msr1, CD36\u548cldlr)\u7684\u8102\u8d28\u6444\u53d6\u589e\u52a0\u800c\u5bfc\u81f4\u7684\u4e0d\u53ef\u63a7\u8102\u8d28\u79ef\u7d2f\u662f\u80bf\u7624\u6d78\u6da6\u6027MDSCs\u4ee3\u8c22\u91cd\u7f16\u7a0b\u7684\u539f\u56e0\u3002\u4e0d\u9971\u548c\u8102\u80aa\u9178(USFAs)\u4fc3\u8fdb\u7ec6\u80de\u5185LD\u7684\u5f62\u6210\uff0c\u6291\u5236MDSCs\u800c\u975eSFAs\u7684\u6d3b\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">(\u03b1-)\u4e9a\u9ebb\u9178(USFA)\u901a\u8fc7\u6fc0\u6d3bJAK-STAT3\u548cROS\uff0c\u663e\u8457\u4fc3\u8fdb\u591a\u5f62\u6838MDSCs\u7684\u6269\u5f20\u548c\u6bd4\u4f8b\uff0c\u5e76\u5bf9T\u7ec6\u80de\u4ea7\u751f\u6bd4SFAs\u4f5c\u7528\u66f4\u5f3a\u7684\u6291\u5236\u4f5c\u7528(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3d<\/span>)\u3002CD36\u57fa\u56e0\u7f3a\u5931\u6216STAT3\/5\u57fa\u56e0\u6291\u5236\u6291\u5236\u4e86MDSCs\u7684\u6c27\u5316\u4ee3\u8c22\u548c\u514d\u75ab\u6291\u5236\u529f\u80fd\uff0c\u5bfc\u81f4ARG1\u548ciNOS\u51cf\u5c11\uff0c\u8fdb\u800c\u5bfc\u81f4CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4f9d\u8d56\u7684\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u5ef6\u8fdf\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e0eTAMs\u76f8\u4f3c\uff0c\u6765\u81eaLewis\u80ba\u764c\u7ec6\u80de\u7684\u5de8\u566c\u7ec6\u80de\u96c6\u675f\u523a\u6fc0\u56e0\u5b50\u4e5f\u53ef\u4ee5\u63d0\u9ad8MDSCs\u4e2dFASN\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u6fc0\u6d3bPPAR-\u03b2\/\u03b4\u4ee5\u53ca\u968f\u540eIL-10\u7684\u5206\u6ccc(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3d<\/span>)\u3002\u6b64\u5916\uff0c\u5fc3\u78f7\u8102\u53ef\u4ee5\u901a\u8fc7\u6fc0\u6d3bMDSCs\u4e2d\u7684PPAR-\u03b3\u6765\u523a\u6fc0IL-10\u7684\u5206\u6ccc\uff0c\u800cMDSCs\u9a7b\u7559\u5728\u8377\u7624\u5c0f\u9f20\u7684\u80ba\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;MDSCs\u66f4\u591a\u5730\u4f9d\u8d56\u4e8eFAO\u6765\u7ef4\u6301\u5176\u514d\u75ab\u6291\u5236\u548c\u80bf\u7624\u4fc3\u8fdb\u80fd\u529b\u3002\u5728\u5355\u6838\u7ec6\u80deMDSCs\u548c\u591a\u5f62\u6838MDSCs\u4e2d\u5747\u89c2\u5bdf\u5230CPT1\u548c3-\u7f9f\u57fa\u9170\u57fa- CoA\u8131\u6c22\u9176\u7684\u9ad8\u8868\u8fbe\uff0c\u514d\u75ab\u6291\u5236\u56e0\u5b50(ARG1\u3001iNOS2\u548cNO)\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u4ee5\u53caT\u7ec6\u80de\u589e\u6b96\u7387\u548cIFN\u7684\u4ea7\u751f\u964d\u4f4e(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3d<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">FAO\u6291\u5236\u5242\u4f9d\u6258\u83ab\u897f\u53ef\u901a\u8fc7\u6291\u5236MDSCs\u7684\u6d78\u6da6\uff0c\u589e\u5f3a\u8fc7\u7ee7T\u7ec6\u80de\u6cbb\u7597\u548c\u4f4e\u5242\u91cf\u5316\u7597\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u8fd9\u8868\u660e\u9776\u5411FAO\u53ef\u4ee5\u9650\u5236MDSCs\u7684\u514d\u75ab\u6291\u5236\u529f\u80fd\uff0c\u4fc3\u8fdb\u5176\u4ed6\u6297\u80bf\u7624\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e0eFAs\u4e0d\u540c\uff0c\u80c6\u56fa\u9187\u5728TAMs\u548cMDSCs\u4e2d\u662f\u4e00\u79cd\u708e\u75c7\u4ecb\u8d28\u3002ABCG1\u5728TAMs\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u4fc3\u8fdb\u80c6\u56fa\u9187\u5916\u6392\u7387\u548c\u968f\u540e\u7684IL-4\u5206\u6ccc\uff0c\u4ee5\u7ef4\u6301\u5176\u6297\u708e\u7279\u6027(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;3b<\/span>)\u3002\u5728\u6765\u81ea\u897f\u65b9\u6837\u996e\u98df\u5582\u517b\u7684Abcg1\u2212\/\u2212\u5c0f\u9f20\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684TAMs\u663e\u793a\u51fa\u8f83\u9ad8\u7684\u51cb\u4ea1\u7387\uff0c\u66f4\u591a\u7ec6\u80de\u4eceM2\u8868\u578b\u5411M1\u8868\u578b\u8f6c\u53d8\uff0c\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u589e\u5f3a\uff0c\u80bf\u7624\u751f\u957f\u964d\u4f4e\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u5de8\u566c\u7ec6\u80de\u7f3a\u4e4fABCG1\u53ef\u6539\u53d8\u56fa\u6709\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u589e\u52a0NK\u7ec6\u80de\u548cCD4+T\u7ec6\u80de\u5728TME\u4e2d\u7684\u6d78\u6da6\uff0c\u963b\u6b62\u80bf\u7624\u751f\u957f\u3002\u7136\u800c\uff0c\u7ec6\u80de\u8272\u7d20P450\u5bb6\u65cf27\u4e9a\u5bb6\u65cfA\u6210\u54581 (CYP27A1)\u662f\u5c06\u80c6\u56fa\u9187\u8f6c\u5316\u4e3a27-\u7f9f\u57fa\u80c6\u56fa\u9187(27HC)\u6240\u9700\u7684\u4e00\u79cd\u7ec6\u80de\u8272\u7d20P450\u6c27\u5316\u9176\uff0c\u5728\u4e73\u817a\u80bf\u7624\u6d78\u6da6\u7684\u5de8\u566c\u7ec6\u80de\u4e0a\u9ad8\u8868\u8fbe\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd9\u610f\u5473\u7740\u6765\u81ea\u5de8\u566c\u7ec6\u80de\u768427HC\u662f\u4e73\u817a\u80bf\u7624\u751f\u957f\u7684\u4fc3\u8fdb\u56e0\u5b50\u3002\u5f53CYP27A1\u88ab\u6291\u5236\u65f6\uff0c\u8fd9\u79cd\u4fc3\u80bf\u7624\u4f5c\u7528\u88ab\u524a\u5f31\u3002\u5176\u673a\u5236\u53ef\u80fd\u662f27HC\u6216\u5176\u4ed6\u80c6\u56fa\u9187\u524d\u4f53\u548c\u7f9f\u753e\u9187\u901a\u8fc7\u6fc0\u6d3bLXRs\u4f7f\u5de8\u566c\u7ec6\u80de\u6781\u5316\u4e3aM2\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5173\u4e8eMDSCs\u80c6\u56fa\u9187\u4ee3\u8c22\u7684\u7814\u7a76\u8fd8\u5f88\u6709\u9650\u3002\u6709\u7814\u7a76\u8ba4\u4e3a\uff0c\u5728\u9ad3\u7cfb\u7ec6\u80de\u4e2d\u7f3a\u5931ABCA1\/ G1\u57fa\u56e0\u53ef\u963b\u65ad\u5176\u80c6\u56fa\u9187\u6d41\u51fa\uff0c\u9650\u5236MDSCs\u548c\u80bf\u7624\u751f\u957f\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">LXR\u6fc0\u52a8\u5242\u901a\u8fc7LXR \u03b2\u6838\u6fc0\u7d20\u53d7\u4f53\u548c\u8f7d\u8102\u86cb\u767dE (ApoE)\u523a\u6fc0\u80c6\u56fa\u9187\u5916\u6392\uff0c\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u4f53\u5916\u548c\u4f53\u5185MDSCs\u7684\u6bd4\u4f8b\u3002\u5728ApoE\u7f3a\u5931\u7684\u8377\u7624\u5c0f\u9f20\u4e2d\uff0c\u5faa\u73af\u548c\u80bf\u7624\u5185\u7684MDSCs\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0c\u4f1a\u5bfc\u81f4\u80bf\u7624\u751f\u957f\u66f4\u5feb\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: 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border-box;\">\u8fd9\u4e9b\u53d1\u73b0\u63d0\u793aMDSCs\u548cTAMs\u4e2d\u80c6\u56fa\u9187\u542b\u91cf\u7684\u589e\u52a0\u53ef\u80fd\u534f\u540c\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u6d88\u9664\u6076\u6027\u80bf\u7624\u3002\u8102\u8d28\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u4e0d\u540c\u4f5c\u7528\u53ef\u80fd\u4e0eFAs\u3001\u80c6\u56fa\u9187\u548c\u6076\u6027\u80bf\u7624\u7684\u4e9a\u578b\u6709\u5173\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u56e0\u6b64\uff0c\u9488\u5bf9\u5de8\u566c\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5e94\u7528\u5e94\u8003\u8651\u8fd9\u4e9b\u77db\u76fe\u7684\u7ed3\u679c\uff0c\u5f00\u53d1\u66f4\u5177\u4f53\u7684\u8102\u8d28\u9776\u5411\u6cbb\u7597\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u53d1\u6325\u5176\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9ad8\u8102\u542b\u91cf\u635f\u5bb3\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6297\u539f\u5448\u9012\u80fd\u529b<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6297\u80bf\u7624\u4f5c\u7528\u4e3b\u8981\u6765\u6e90\u4e8e\u5176\u6297\u539f\u63d0\u5448\u80fd\u529b\u3002\u867d\u7136\u9ad8\u8102\u542b\u91cf\u4f7f\u809d\u810fDCs\u5177\u6709\u66f4\u5f3a\u7684\u4ea4\u53c9\u63d0\u5448\u80fd\u529b\uff0c\u4f46\u8bb8\u591a\u7814\u7a76\u8868\u660eFAs\u4e5f\u53ef\u80fd\u662f\u80bf\u7624\u6d78\u6da6\u6027DCs\u4e2d\u7684\u514d\u75ab\u6291\u5236\u56e0\u5b50\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u996e\u98df\u8bf1\u5bfc\u7684\u80a5\u80d6\u5bfc\u81f4\u5171\u523a\u6fc0\u5206\u5b50\u548cDC\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u8868\u8fbe\u53d7\u9650\uff0c\u4ece\u800c\u8bf1\u5bfcDCs\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\u6fc0\u6d3bT\u7ec6\u80de\u3002\u6b64\u5916\uff0c\u5728\u8f90\u5c04\u8bf1\u5bfc\u7684\u80f8\u817a\u6dcb\u5df4\u7624\u4e2d\uff0c\u8102\u86cb\u767d\u8102\u80aa\u9176\u548cFABP1\u6c34\u5e73\u5347\u9ad8\u5bfc\u81f4\u8840\u6e05TAG\u6c34\u5e73\u5347\u9ad8\uff0c\u5e76\u5bfc\u81f4DC\u529f\u80fd\u969c\u788d\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u8102\u8d28\u503e\u5411\u4e8e\u4ecb\u5bfc\u6765\u81eaDCs\u7684\u524d\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0cTME\u5185\u7684\u53ef\u6eb6\u6027\u56e0\u5b50\u901a\u8fc7\u4e0a\u8c03\u6811\u7a81\u72b6\u7ec6\u80de\u6c27\u5316\u4e2d\u6027\u8102\u8d28\u542b\u91cf\uff0c\u9650\u5236\u4e86MHC I\u7c7b\u590d\u5408\u7269\u7684\u5f62\u6210\uff0c\u524a\u5f31\u4e86\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u3002\u540c\u65f6\uff0cSFAs\u548cPUSFAs\u663e\u8457\u964d\u4f4eDCs\u7684\u5206\u5316\u548c\u6fc0\u6d3b\uff0c\u8fdb\u800c\u964d\u4f4eT\u7ec6\u80de\u529f\u80fd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5de8\u566c\u7ec6\u80de\u6e05\u507f\u5242\u53d7\u4f531 (Macrophage scavenger receptor 1, MSR1)\u662f\u5bfc\u81f4DC\u7ec6\u80de\u4e2dFA\u6c34\u5e73\u5347\u9ad8\u548cCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u88ab\u8bf1\u5bfc\u80fd\u529b\u53d7\u9650\u7684\u539f\u56e0(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;3c<\/span>)\u3002\u963b\u65adMSR1\u4f1a\u524a\u5f31DCs\u4e2dFA\u7684\u79ef\u7d2f\uff0c\u4ece\u800c\u523a\u6fc0\u8fc7\u4ece\u6027\u53cd\u5f0f\u8f6c\u5316\u7684\u80bf\u7624\u7279\u5f02\u6027CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u5728\u4e73\u817a\u80bf\u7624\u4e2d\u7684\u6269\u5f20\u548c\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u53e6\u4e00\u79cd\u8102\u8d28\u6444\u53d6\u86cb\u767d\u7c7b\u56fa\u9187\u53d7\u4f53RNA\u6fc0\u6d3b\u56e0\u5b501\u4e5f\u5f71\u54cdDCs\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u548c\u514d\u75ab\u539f\u6027\u3002\u963b\u65ad\u6811\u7a81\u72b6\u7ec6\u80deFA\u6444\u53d6\u6216\u635f\u5bb3\u6811\u7a81\u72b6\u7ec6\u80de\u8102\u8d28\u5408\u6210\u53ef\u901a\u8fc7\u63d0\u9ad8T\u7ec6\u80de\u7684\u53d7\u523a\u6fc0\u80fd\u529b\u6765\u51cf\u5f31\u764c\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u72b6\u6001\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0cZhao\u7b49\u53d1\u73b0\u9ed1\u7d20\u7624\u53ef\u4ee5\u901a\u8fc7Wnt5a-\u03b2-catenin PPAR-\u03b3\u4fe1\u53f7\u901a\u8def\u4e0a\u8c03CPT1A\u7684\u8868\u8fbe\uff0c\u589e\u5f3aDCs\u4e2d\u7684FAO\u3002\u8fd9\u79cd\u8f6c\u79fb\u589e\u5f3a\u4e86\u5432\u54da\u80fa2,3-\u53cc\u6c27\u5408\u9176-1\u7684\u6570\u91cf\u548c\u6d3b\u6027\uff0c\u540c\u65f6\u6291\u5236\u4e86IL-6\u548cIL-12\u7684\u8868\u8fbe\uff0c\u6700\u7ec8\u5bfc\u81f4Treg\u7684\u4ea7\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6811\u7a81\u72b6\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u969c\u788d\u4f1a\u5bfc\u81f4LD\u79ef\u7d2f\u3002LD\u901a\u8fc7\u964d\u4f4eMHC\u8868\u8fbe\u548cAg\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u523a\u6fc0\u80fd\u529b\uff0c\u6765\u524a\u5f31DCs\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u9178\u6027TME\u4e2d\uff0c\u81ea\u5206\u6cccTGF-\u03b22\u5bfc\u81f4LD\u5728DCs\u4e2d\u5f02\u5e38\u79ef\u7d2f\uff0c\u6291\u5236\u5176\u5411\u6dcb\u5df4\u7ed3\u7684\u589e\u6b96\u548c\u8fc1\u79fb\u80fd\u529b\u4ee5\u53caCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u523a\u6fc0\u80fd\u529b(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;3c<\/span>)\u3002\u800cSB\u2010431542\u662f\u4e00\u79cd\u6709\u6548\u7684TGF-\u03b2 I\u53d7\u4f53\u6291\u5236\u5242\uff0c\u53ef\u51cf\u5f31TGF-\u03b2\u5f15\u8d77\u7684DC\u75ab\u82d7\u7684\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u672c\u7814\u7a76\u63d0\u793a\uff0c\u5c0f\u5206\u5b50\u6291\u5236\u5242\u53ef\u80fd\u901a\u8fc7\u5f71\u54cd\u8102\u8d28\u4ee3\u8c22\u6765\u8c03\u8282\u80bf\u7624\u514d\u75ab\u3002\u57fa\u4e8e\u4ee5\u4e0a\u8ba8\u8bba\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u8fd9\u4e9b\u5f02\u5e38\u79ef\u7d2f\u7684\u8102\u8d28\u6240\u5904\u7684\u5668\u5b98\u6216\u8102\u8d28\u79cd\u7c7b\u7684\u4e0d\u540c\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u5185\u8102\u8d28\u79ef\u7d2f\u7684\u786e\u5207\u4f5c\u7528\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6839\u636e\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6807\u8bb0\u548c\u5f62\u6001\uff0c\u5c06\u6811\u7a81\u72b6\u7ec6\u80de\u5206\u4e3a\u9ad3\u7cfb\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de\u3002\u8fd9\u4e24\u79cd\u4e9a\u578b\u662f\u5426\u5177\u6709\u4e0d\u540c\u7684\u8102\u4ee3\u8c22\u6a21\u5f0f\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u5e94\u4fa7\u91cd\u4e8e\u68c0\u6d4b\u80bf\u7624\u76f8\u5173\u6811\u7a81\u72b6\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7684\u5177\u4f53\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u5728\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">NK\u7ec6\u80de\u901a\u8fc7\u4ea7\u751f\u7a7f\u5b54\u7d20\u3001GzmB\u7b49\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u6216IFN-\u03b3\u3001TNF\u7b49\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\uff0c\u76f4\u63a5\u6740\u4f24\u80bf\u7624\u7ec6\u80de\uff0c\u662f\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u5feb\u901f\u6709\u6548\u7684\u5e94\u7b54\u8005\u3002TME\u4e2d\u7684\u8bb8\u591a\u56e0\u5b50\u90fd\u4f1a\u5bfc\u81f4NK\u7ec6\u80de\u4ece\u7cd6\u9175\u89e3\u5230\u6c27\u5316\u78f7\u9178\u5316\u7684\u8f6c\u6362\uff0c\u4f7f\u5176\u6297\u80bf\u7624\u7279\u6027\u5931\u6d3b\uff0c\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u9003\u9038\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5bcc\u542b\u8102\u8d28\u7684TME\u8feb\u4f7f\u80bf\u7624\u6d78\u6da6\u7684NK\u7ec6\u80de\u6444\u53d6\u66f4\u591a\u7684\u8102\u8d28\uff0c\u4ece\u800c\u6291\u5236\u7ec6\u80de\u6bd2\u6027\u56e0\u5b50\u7684\u6d41\u52a8\uff0c\u53ca\u7531\u4e8e\u201c\u4ee3\u8c22\u9ebb\u75f9\u201d\u5728\u4f53\u5185\u548c\u4f53\u5916\u4ea7\u751f\u7684\u6297\u80bf\u7624\u529f\u80fd\u3002\u8f6c\u5f55\u5206\u6790\u8868\u660e,\u9ad8\u6c34\u5e73\u7684mTOR\u53ef\u4ee5\u523a\u6fc0PPAR -\u03b1\/\u03b4\u76ee\u6807\u57fa\u56e0\uff0c\u5305\u62ec\u5f71\u54cd\u53c2\u4e0e\u8102\u8d28\u548c\u7518\u6cb9\u5438\u6536(Cd36, Lpl\u548cLrp4)\u7684\u57fa\u56e0\uff0c\u5f71\u54cdLD\u5f62\u6210\u548c\u4f7f\u8102\u9176(\u65f6\u95f4\u548cPlin2)\u53ca\u8102\u8d28\u4ee3\u8c22(Abca1\u3001Scarb2 Gyk)\u5728\u9ad8\u8102\u80aa\u996e\u98df\u5c0f\u9f20NK\u7ec6\u80de\u4e2d\uff0c\u8868\u73b0\u51fa\u4f4e\u7ec6\u80de\u6bd2\u6027(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. 3e<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">mTOR\u662f\u7ec6\u80de\u4ee3\u8c22\u7684\u4e3b\u8981\u8c03\u8282\u56e0\u5b50\uff0c\u8c03\u63a7NK\u7ec6\u80de\u7684\u53d1\u80b2\u548c\u6d3b\u5316\u3002\u6572\u9664NK\u7ec6\u80de\u4e2dCISH\u57fa\u56e0\u53ef\u523a\u6fc0mTOR\u4fe1\u53f7\u901a\u8def\uff0c\u589e\u52a0NK\u7ec6\u80de\u4ee3\u8c22\u9002\u5e94\u5ea6\uff0c\u8fdb\u800c\u63d0\u9ad8\u5176\u6297\u80bf\u7624\u80fd\u529b\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u80a5\u80d6\u53ef\u4ee5\u901a\u8fc7mTOR-PPAR\u901a\u8def\u6765\u5f71\u54cd\u80bf\u7624\u76f8\u5173NK\u7ec6\u80de\u3002\u56e0\u6b64\uff0cPPAR\u9776\u5411\u6cbb\u7597\u53ef\u4ee5\u901a\u8fc7\u51cf\u5c11\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u548c\u6fc0\u6d3bNK\u7ec6\u80de\u80fd\u529b\u7684\u540c\u65f6\uff0c\u6d88\u9664\u80bf\u7624\u751f\u957f\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9664\u5b9e\u4f53\u7624\u5916\uff0c\u6765\u81ea\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u4e2a\u4f53\u7684NK\u7ec6\u80de\u4e2d\u8102\u8d28\u4ee3\u8c22\u589e\u52a0\uff0cIFN-\u03b3\u8868\u8fbe\u964d\u4f4e\u3002\u8f6c\u5f55\u5206\u6790\u663e\u793a\uff0c\u5728\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u5c0f\u9f20\u4e2d\uff0c\u8102\u8d28\u4ee3\u8c22\u76f8\u5173\u57fa\u56e0\uff0c\u5305\u62ecCd36\u3001Fabp4\u3001Fabp5\u548cPparg\u51fa\u73b0\u5bcc\u96c6\uff0c\u8fd9\u4e0e\u4e2d\u6027\u8102\u8d28\u6c34\u5e73\u7684\u663e\u8457\u5347\u9ad8\u76f8\u4e00\u81f4\u3002\u4f53\u5185\u5b9e\u9a8c\u4e5f\u8bc1\u5b9e\uff0c\u5728\u8f83\u4f4e\u6d53\u5ea6\u7684FAs\u7ec4\u5408\u7684\u6a21\u62df\u751f\u7406\u6761\u4ef6\u4e0b\uff0cIFN-\u03b3\u548cGzmB\u663e\u8457\u964d\u4f4e\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4e00\u4e2a\u6709\u8da3\u7684\u73b0\u8c61\u662f\uff0c\u8377\u7624\u5c0f\u9f20\u7684\u624b\u672f\u6cbb\u7597\u53ef\u4e0a\u8c03CD36\u9ad8\u8868\u8fbe\u3001GzmB\u4f4e\u8868\u8fbe\u7684\u813eNK\u7ec6\u80de\u8102\u8d28\u542b\u91cf\u3002\u8fd9\u4e00\u7ed3\u679c\u63d0\u793a\uff0c\u6076\u6027\u80bf\u7624\u624b\u672f\u540e\u7684\u8102\u8d28\u4f9b\u5e94\u53ef\u80fd\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4ea7\u751f\u4e0d\u826f\u5f71\u54cd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u6211\u4eec\u53ef\u4ee5\u4ece\u4e0a\u8ff0\u8ba8\u8bba\u4e2d\u63a8\u65ad\uff0c\u80c6\u56fa\u9187\u5bf9NK\u7ec6\u80de\u7684\u6297\u80bf\u7624\u80fd\u529b\u6709\u4fc3\u8fdb\u4f5c\u7528\uff0c\u800cFA\u7684\u79ef\u7d2f\u5219\u53ef\u80fd\u6ca1\u6709\u4fc3\u8fdb\u4f5c\u7528\u3002\u8fd9\u610f\u5473\u7740\u5728NK\u7ec6\u80de\u9776\u5411\u6cbb\u7597\u4e2d\uff0c\u6291\u5236FAs\u548c\u4fc3\u8fdb\u80c6\u56fa\u9187\u7684\u5171\u540c\u4f5c\u7528\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u589e\u5f3a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">Ns\u4e5f\u88ab\u53d1\u73b0\u53ef\u80fd\u53c2\u4e0e\u80bf\u7624\u76f8\u5173\u7684\u514d\u75ab\u53cd\u5e94\u3002\u4e0e\u541e\u566c\u7ec6\u83cc\u3001\u8bf1\u5bfc\u7ec4\u7ec7\u635f\u4f24\u3001\u5728\u611f\u67d3\u4e2d\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u7b49\u6b63\u5e38\u80fd\u529b\u76f8\u53cd\uff0c\u80bf\u7624\u76f8\u5173\u7684Ns\u88ab\u8ba4\u4e3a\u53c2\u4e0e\u4e86\u80bf\u7624\u524d\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\uff0cNs\u901a\u8fc7\u52a0\u901f\u5f25\u6563\u6027\u80bf\u7624\u7ec6\u80de\u7684\u8fc1\u79fb\u548c\u589e\u6b96\uff0c\u5e76\u901a\u8fc7\u4e2d\u6027\u7c92\u7ec6\u80de\u80de\u5916\u9677\u9631\u5524\u9192\u5b83\u4eec\uff0c\u6765\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u5411\u80ba\u8f6c\u79fb\u30024T1\u80bf\u7624\u6a21\u578b\u80ba\u8f6c\u79fb\u524d\u7ec4\u7ec7\u4e2d\uff0cNs\u9ad8\u8868\u8fbe\u4e0e\u8102\u8d28\u5438\u6536\u548cLD\u5f62\u6210\u76f8\u5173\u57fa\u56e0\uff0c\u4f4e\u8868\u8fbe\u4e0e\u53c2\u4e0eLD\u964d\u89e3\u548c\u03b2-\u6c27\u5316\u7684\u76f8\u5173\u57fa\u56e0\u3002\u8fd9\u610f\u5473\u7740\uff0c\u80ba\u5185Ns\u5177\u6709\u8102\u8d28\u79ef\u805a\u7684\u6f5c\u529b\uff0c\u8fd9\u79cd\u6f5c\u529b\u4f1a\u764c\u75c7\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u589e\u5f3a\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u540c\u65f6\uff0c\u6765\u81ea\u95f4\u5145\u8d28\u7ec6\u80de\u7684\u524d\u5217\u817a\u7d20E2\u901a\u8fc7\u6fc0\u6d3bHilpda\u6291\u5236ATGL\uff0c\u4fc3\u8fdbNs\u4e2dLD\u7684\u5f62\u6210\u3002\u7136\u540e\u8fd9\u4e9bLDs\u88ab\u8f6c\u79fb\u5230\u764c\u7ec6\u80de\u4e2d\uff0c\u4fc3\u8fdb\u80bf\u7624\u8f6c\u79fb(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;3f<\/span>)\u3002\u4e0e\u91ce\u751f\u578b\u5c0f\u9f20\u76f8\u6bd4\uff0cAtgl\u2212\/\u2212\u5c0f\u9f20\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u81ea\u53d1\u80ba\u8f6c\u79fb\uff0c\u4f46\u539f\u53d1\u80bf\u7624\u751f\u957f\u6ca1\u6709\u6539\u53d8\u3002\u540c\u65f6\uff0c\u80c6\u56fa\u9187\u4e5f\u4f1a\u5f71\u54cd\u80bf\u7624\u6d78\u6da6\u7684Ns\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u80bf\u7624\u6765\u6e90\u7684\u7f9f\u753e\u9187\u901a\u8fc7CXCR2\u4f9d\u8d56\u9014\u5f84\u62db\u52df\u80bf\u7624\u524dNs\uff0c\u4fc3\u8fdb\u65b0\u8840\u7ba1\u751f\u6210\u548c\u514d\u75ab\u6291\u5236\u3002\u767e\u65e5\u6d41\u6bd2\u7d20\u6291\u5236CD11bhigh Gr1high Ly6G+\u7ec6\u80de\u541122(R)-\u7f9f\u57fa\u80c6\u56fa\u9187\u7684\u8fc1\u79fb\uff0c\u8fd9\u8868\u660eG\u86cb\u767d\u5076\u8054\u53d7\u4f53\u4ecb\u5bfc\u8fd9\u4e9b\u7ec6\u80de\u5411LXR\u914d\u4f53\u7684\u8fc1\u79fb\uff0c\u5e76\u968f\u540e\u6fc0\u6d3bCXCR2\u4fe1\u53f7(<span style=\"color: rgb(203, 47, 21);box-sizing: border-box;\">Fig. &nbsp;3f<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5f53\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\uff0c\u963b\u65ad\u7f9f\u753e\u9187CXCR2\u8f74\u548c\u635f\u5bb3\u4e2d\u6027\u7c92\u7ec6\u80de\u8fc1\u79fb\u65f6\uff0c\u4f1a\u51fa\u73b0\u66f4\u597d\u7684\u5ef6\u8fdf\u80bf\u7624\u751f\u957f\u548c\u5ef6\u957f\u603b\u751f\u5b58\u7684\u6548\u679c\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u80bf\u7624\u6d78\u6da6Ns\u4e2d\u7684\u8102\u8d28\u4ee3\u8c22\uff0c\u6709\u671b\u4e3a\u6076\u6027\u80bf\u7624\u7684\u6cbb\u7597\uff0c\u7279\u522b\u662f\u5728\u9650\u5236\u8f6c\u79fb\u65b9\u9762\uff0c\u5f00\u8f9f\u65b0\u7684\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: flex;flex-flow: row nowrap;margin: 20px 0% 10px;justify-content: flex-start;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;box-sizing: border-box;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u8102\u8d28\u4ee3\u8c22\u4e0e\u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u63ed\u793a\u4e86\u8102\u8d28\u4ee3\u8c22\u5728\u80bf\u7624\u53d1\u751f\u3001\u8fdb\u5c55\u548c\u8f6c\u79fb\u4ee5\u53ca\u8c03\u8282\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002\u6709\u7814\u7a76\u8005\u63d0\u51fa\u4e86\u5229\u7528\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5f02\u5e38\u8102\u8d28\u4ee3\u8c22\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u3002\u800c\u9274\u4e8e\u5404\u79cd\u5df2\u88ab\u5f00\u53d1\u5229\u7528\u4e8e\u6cbb\u7597\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u9488\u5bf9\u8102\u8d28\u4ee3\u8c22\u7684\u6291\u5236\u5242\uff0c\u91cd\u65b0\u5229\u7528\u73b0\u6709\u836f\u7269\uff0c\u9488\u5bf9\u764c\u75c7\u4e2d\u7684\u5f02\u5e38\u8102\u8d28\u4ee3\u8c22\u7684\u65b9\u6cd5\u53ef\u80fd\u662f\u6709\u6548\u7684\u3002\u7136\u800c\uff0c\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u9488\u5bf9\u8102\u8d28\u4ee3\u8c22\u7684\u6cbb\u7597\u53ef\u80fd\u540c\u65f6\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8bb8\u591a\u9488\u5bf9\u80bf\u7624\u8102\u8d28\u4ee3\u8c22\u7684\u6cbb\u7597\u5728\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u65b9\u9762\u53d6\u5f97\u4e86\u663e\u8457\u6210\u6548\u3002&nbsp;<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9274\u4e8e\u5916\u6e90\u6027FA\u7684\u6444\u53d6\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4f9d\u8d56\u4e8eCD36\u7684\u8868\u8fbe\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5e94\u7528CD36\u6291\u5236\u5242\u53ef\u963b\u788d\u591a\u79cd\u764c\u75c7\u7684\u751f\u957f\uff0c\u5e76\u5728\u4e0eFASN\u6291\u5236\u5242\u548c\u6297PD -1\u7597\u6cd5\u7ed3\u5408\u65f6\u663e\u793a\u534f\u540c\u4f5c\u7528\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6291\u5236CD36\u9664\u4e86\u53ef\u4ee5\u76f4\u63a5\u6d88\u9664\u80bf\u7624\u7ec6\u80de\u5916\uff0c\u8fd8\u53ef\u4ee5\u901a\u8fc7\u6d88\u9664\u80bf\u7624\u5185Tregs\u7684\u529f\u80fd\u6765\u7ec6\u5316\u514d\u75ab\u6291\u5236TME\uff0c\u6291\u5236\u80bf\u7624\u8fdb\u5c55\u3002\u540c\u65f6\uff0c\u7528\u5355\u514b\u9686\u6297\u4f53\u963b\u65adDCs\u4e0a\u7684CD36\uff0c\u4f7f\u5176MHC II\u7c7b\u5206\u5b50\u7684\u6297\u539f\u5448\u9012\u80fd\u529b\u51cf\u5f31\uff0c\u4ece\u800c\u6539\u5584CD4<sup style=\"font-size: 12px;box-sizing: border-box;\">+ <\/sup>T\u7ec6\u80de\u542f\u52a8\uff0c\u8fdb\u800c\u589e\u5f3a\u5176\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table &nbsp;2<\/span>)\u3002\u6b64\u5916\uff0c\u6c89\u9ed8DCs\u4e0a\u7684MSR1\u53ef\u63d0\u9ad8DC\u7684\u63a5\u79cd\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9664\u8102\u80aa\u9178\u5438\u6536\u5916\uff0c\u8102\u80aa\u9178\u4ece\u5934\u5408\u6210\u4e5f\u5360\u8102\u80aa\u6765\u6e90\u7684\u5f88\u5927\u6bd4\u4f8b\u3002ACLY\u5c06\u67e0\u6aac\u9178\u76d0\u548c\u8f85\u9176a\u8f6c\u5316\u4e3a\u4e59\u9170\u8f85\u9176a\u548c\u8349\u9170\u4e59\u9178\u76d0\uff0c\u5c06\u7cd6\u9175\u89e3\u548c\u8102\u7c7b\u5408\u6210\u8fde\u63a5\u5728\u4e00\u8d77\u3002ACC\u50ac\u5316\u4e59\u9170\u8f85\u9176a\u5411\u4e19\u4e8c\u9170\u8f85\u9176a\u7684\u8f6c\u5316\u3002\u901a\u8fc7\u6291\u5236\u5242\u6216siRNA\u5e72\u6270\u5176\u8868\u8fbe\uff0c\u8fdb\u800c\u8bf1\u5bfc\u80bf\u7624\u51cb\u4ea1\uff0c\u9650\u5236\u80bf\u7624\u751f\u957f\uff0c\u5e76\u534f\u540c\u589e\u5f3a\u5316\u7597\u6216\u9776\u5411\u836f\u7269\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u817a\u82f75 &#8216;\u5355\u78f7\u9178\u6d3b\u5316\u86cb\u767d\u6fc0\u9176(Adenosine 5 &#8216; monophospe -activated protein kinase, AMPK)\u662fACC\u7684\u5173\u952e\u6291\u5236\u56e0\u5b50\uff0c\u4e8c\u7532\u53cc\u80cd\u662fAMPK\u7684\u5178\u578b\u6fc0\u52a8\u5242\u3002AMPK\u9664\u76f4\u63a5\u5f71\u54cd\u80bf\u7624\u7ec6\u80de\u5916\uff0c\u8fd8\u53ef\u80fd\u5f71\u54cd\u80bf\u7624\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u7684\u8102\u8d28\u4ee3\u8c22\u3002\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u62a5\u9053\uff0c\u4f4e\u5242\u91cf\u4e8c\u7532\u53cc\u80cd\u7684\u5e94\u7528\u589e\u52a0\u4e86TME\u4e2dCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup>T\u7ec6\u80de\u7684\u6570\u91cf\u5e76\u51cf\u5c11\u4e86\u80bf\u7624\u76f8\u5173\u7684\u5de8\u566c\u7ec6\u80de(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table 2<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7136\u800c\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u62a5\u9053\uff0c\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u6d88\u8017ACLY\u5e76\u4e0d\u80fd\u589e\u5f3a\u5c0f\u9f20\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u786c\u8102\u9170\u8f85\u9176a\u53bb\u9971\u548c\u9176(SCD)\u662fFA\u5408\u6210\u7684\u53e6\u4e00\u79cd\u5173\u952e\u9176\uff0c\u4e0e\u80bf\u7624\u53d1\u751f\u3001\u80bf\u7624\u8fdb\u5c55\u548c\u603b\u751f\u5b58\u671f\u76f8\u5173\u3002SCD1\u6291\u5236\u5242\u548c\u9776\u5411\u6cbb\u7597\u5728\u764c\u75c7\u4e2d\u53d1\u6325\u534f\u540c\u6291\u5236\u4f5c\u7528\u3002\u867d\u7136SCD\u5728\u708e\u75c7\u6027\u75be\u75c5\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u4f46\u5c1a\u65e0\u76f4\u63a5\u8bc1\u636e\u663e\u793a\u5176\u4e0e\u80bf\u7624\u514d\u75ab\u7684\u5173\u7cfb\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6765\u81eaFASN\u50ac\u5316\u7684Acetoacetyl-CoA\u5c06FA\u7684\u751f\u7269\u5408\u6210\u4e0e\u80c6\u56fa\u9187\u7684\u751f\u7269\u5408\u6210\u8054\u7cfb\u8d77\u6765\uff0c\u4fc3\u8fdb\u8102\u7b4f\u548cToll\u6837\u53d7\u4f53(TLR) 4\u4fe1\u53f7\u901a\u8def\u7684\u5f62\u6210\uff0c\u6fc0\u6d3b\u5de8\u566c\u7ec6\u80de\u4e2d\u66f4\u9ad8\u6c34\u5e73\u7684\u7ec6\u80de\u56e0\u5b50\u53cd\u5e94\u3002FASN\u6291\u5236\u5242C75\u53ef\u4ee5\u6291\u5236\u5c0f\u9f20\u9aa8\u9ad3\u6e90\u6027\u5de8\u566c\u7ec6\u80de\u8102\u8d28\u5408\u6210\uff0c\u53ef\u964d\u4f4eIL-1\u03b2\u3001IL-10\u3001IL-6\u3001\u548cTNF-\u03b1\u6c34\u5e73\u5bf9\u5404\u79cdTLR\u6fc0\u52a8\u5242\u7684\u54cd\u5e94(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table 2<\/span>)\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u4e00\u4e9b\u9488\u5bf9FASN\u7684\u65b0\u5316\u5408\u7269\u5df2\u7ecf\u5f00\u53d1\u51fa\u6765\uff0c\u5b83\u4eec\u5177\u6709\u8f83\u8f7b\u7684\u526f\u4f5c\u7528\u548c\u6709\u6548\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u8fdb\u4e00\u6b65\u5206\u6790\u8fd9\u4e9b\u836f\u7269\u5bf9\u80bf\u7624\u514d\u75ab\u7684\u5f71\u54cd\u662f\u5fc5\u8981\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">FA\u5206\u89e3\u5728\u80bf\u7624\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u4e2d\u4e5f\u5f88\u91cd\u8981\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u6291\u5236\u5de8\u566c\u7ec6\u80de\u4e2d\u4e8c\u9170\u57fa\u7518\u6cb9\u9170\u57fa\u8f6c\u79fb\u9176(A922500, mf -06424439)\u3001ATGL (SML1075)\u548cMAGL (SML0872)\u7684\u50ac\u5316\u6d3b\u6027\u4f1a\u51cf\u5f31\u5176\u514d\u75ab\u6291\u5236\u80fd\u529b\u3002\u9776\u5411CPT1\u7684\u7597\u6cd5\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u4f8b\u5982\u51cf\u5c11\u809d\u7ec6\u80de\u764c\u7ec6\u80de\u4e2dinvadopodia\u7684\u5f62\u6210\u5e76\u6d88\u9664TAM\u5728\u4f53\u5185\u548c\u4f53\u5185\u7684\u4fc3\u80bf\u7624\u4f5c\u7528(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table &nbsp;2<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">etomoxir\u6291\u5236FAO\u5bf9TME\u4e2dF4\/80<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup>\u5de8\u566c\u7ec6\u80de\u7684\u6570\u91cf\u6ca1\u6709\u5f71\u54cd\uff0c\u4f46\u964d\u4f4e\u4e86F4\/80<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup>\u5de8\u566c\u7ec6\u80de\u5bf9\u80f0\u7ba1\u817a\u764c\u7ec6\u80de\u7684\u541e\u566c\u3002\u5728\u5176\u4ed6\u7c7b\u578b\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u4e2d\uff0c\u4f9d\u6258\u83ab\u897f\u4e0e\u8fc7\u4eceT\u7ec6\u80de\u6cbb\u7597\u548c\u4f4e\u5242\u91cf\u5316\u7597\u5177\u6709\u534f\u540c\u4f5c\u7528\uff0c\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u6d78\u6da6\u7684MDSCs\uff0c\u63d0\u9ad8\u6297\u80bf\u7624\u7597\u6548\u3002\u53e6\u4e00\u79cdFAO\u6291\u5236\u5242perhexiline\u53ef\u4f7f\u4e73\u817a\u764c\u5e72\u7ec6\u80de\u5bf9\u5316\u7597\u91cd\u65b0\u654f\u611f\uff0c\u5e76\u589e\u5f3aCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> Tefs\u7684\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6240\u6709\u8fd9\u4e9b\u7814\u7a76\u90fd\u4e3a\u80bf\u7624\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u4e2dFA\u4ee3\u8c22\u7684\u5e72\u6270\u63d0\u4f9b\u4e86\u6709\u529b\u7684\u8bc1\u636e\uff0c\u540c\u65f6\u8bc1\u660e\u53ef\u4ee5\u901a\u8fc7\u8be5\u9014\u5f84\u56de\u907f\u80bf\u7624\u7ec6\u80de\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002\u80bf\u7624\u76f8\u5173\u7684\u514d\u75ab\u7ec6\u80de\u4e00\u65e6\u4ece\u4ee3\u8c22\u963b\u6ede\u4e2d\u91ca\u653e\u51fa\u6765\uff0c\u5c31\u4f1a\u4ece\u524d\u80bf\u7624\u8868\u578b\u8f6c\u53d8\u4e3a\u6297\u80bf\u7624\u8868\u578b\uff0c\u5e76\u5355\u72ec\u6216\u4e0e\u5176\u4ed6\u7597\u6cd5\u8054\u5408\u8868\u73b0\u51fa\u589e\u5f3a\u7684\u80bf\u7624\u6e05\u9664\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9664\u4e86FAs\uff0c\u80c6\u56fa\u9187\u4e5f\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u4e2d\u7684\u91cd\u8981\u8102\u8d28\u3002LXRs\u662f\u81b3\u98df\u80c6\u56fa\u9187\u7684\u4e3b\u8981\u4f20\u611f\u5668\uff0c\u901a\u8fc7\u589e\u52a0\u80c6\u56fa\u9187\u7684\u6392\u6cc4\u548c\u51cf\u5c11\u80c6\u56fa\u9187\u7684\u5438\u6536\uff0c\u8f6c\u5f55\u8c03\u8282\u80c6\u56fa\u9187\u7a33\u6001\u3002LXR\u6fc0\u52a8\u5242\u53ef\u6709\u6548\u8bf1\u5bfc\u5c0f\u9f20\u6a21\u578b\u80bf\u7624\u6d88\u9000\u5e76\u5ef6\u957f\u5c0f\u9f20\u751f\u5b58\u3002\u5728\u514d\u75ab\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cLXR\u6fc0\u6d3b\u663e\u793a\u51fa\u660e\u663e\u7684\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u8fd9\u8868\u660e\u514d\u75ab\u7ec6\u80de\u53c2\u4e0e\u4e86LXR\u6fc0\u52a8\u8bf1\u5bfc\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002LXR\u6fc0\u52a8\u5242GW3965\u4e0e\u4e00\u7ebf\u836f\u7269\u8fbe\u5361\u5df4\u55ea\u548c\u6297CTLA-4\u6297\u4f53\u8054\u5408\u4f7f\u7528\u65f6\u8868\u73b0\u51fa\u52a0\u6027\u6297\u80bf\u7624\u6548\u679c\u3002RGX-104\u6fc0\u6d3bLXRs\uff0c\u901a\u8fc7\u4e0a\u8c03\u4fc3\u51cb\u4ea1Bcl-2\u5bb6\u65cf\u6210\u5458\u7684\u8868\u8fbe\u6291\u5236MDSCs\u7684\u751f\u5b58\u548c\u514d\u75ab\u6291\u5236\u529f\u80fd(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table &nbsp;2<\/span>)\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7531\u4e8e\u7ec6\u80de\u819c\u4e2d\u7684\u6e38\u79bb\u80c6\u56fa\u9187\u53ef\u4ee5\u4fc3\u8fdbT\u7ec6\u80de\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u4f7f\u7528avasimibe\u6291\u5236ACAT\u5728\u4f7f\u7528\u6216\u4e0d\u4f7f\u7528\u6297PD -1\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u51cf\u5c11\u80bf\u7624\u8fdb\u5c55\u4e2d\u6709\u6df1\u8fdc\u7684\u7597\u6548(Table &nbsp;2)\u3002avasimibe\u548cchemo\u8054\u5408\u5e94\u7528\u4e5f\u80fd\u589e\u5f3aB16F10\u9ed1\u7d20\u7624\u5f02\u79cd\u79fb\u690d\u53ca\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2dCTL\u548cPTX\/\u03b1GC-TH-Lip\u7684\u6297\u80bf\u7624\u80fd\u529b(<span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table &nbsp;2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7531\u4e8e\u5176\u7269\u7406\u5316\u5b66\u548c\u751f\u7269\u7279\u6027\uff0c\u8102\u8d28\u9664\u4e86\u80fd\u4f5c\u4e3a\u80fd\u91cf\u6765\u6e90\u6216\u7269\u7406\u8c03\u8282\u5668\u5916\uff0c\u8fd8\u53ef\u4ee5\u88ab\u6539\u9020\u4e3a\u6709\u6548\u7684\u8f6c\u8fd0\u4f53\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8102\u57fa\u56ca\u6ce1\uff0c\u5305\u62ec\u8102\u8d28\u4f53\u3001\u56fa\u4f53\u8102\u57fa\u7cfb\u7edf\u3001\u8102\u8d28\u9897\u7c92\u3001\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\u56ca\u6ce1\u548c\u80f6\u675f\uff0c\u5747\u5df2\u88ab\u5f00\u53d1\u4e3a\u836f\u7269\u8f7d\u4f53\uff0c\u80fd\u63d0\u9ad8\u836f\u7269\u4f20\u9012\u6548\u7387\uff0c\u5e76\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d6\u5f97\u4e86\u4ee4\u4eba\u6ee1\u610f\u7684\u7ed3\u679c\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u4f53\u662f\u7b2c\u4e00\u79cd\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u3002\u8102\u8d28\u4f53\u5177\u6709\u8f83\u9ad8\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u751f\u7269\u964d\u89e3\u6027\uff0c\u53ef\u63d0\u4f9b\u591a\u79cd\u9776\u5411\u7279\u5f02\u6027\u9ad8\u7684\u6709\u6548\u8f7d\u8377\uff0c\u6709\u52a9\u4e8e\u5316\u7597\u836f\u7269\u8fdb\u5165TME\uff0c\u5e76\u9650\u5236\u836f\u7269\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002Doxil\u00ae\u662fFDA\u6279\u51c6\u7684\u7b2c\u4e00\u79cd\u7528\u8102\u8d28\u4f53\u5305\u5c01\u963f\u9709\u7d20\u7684\u7eb3\u7c73\u836f\u7269\uff0c\u5b83\u53ef\u4ee5\u5229\u7528\u5176\u7279\u5f02\u6027\u8fdb\u884c\u80bf\u7624\u5b9a\u4f4d\uff0c\u5e76\u5728\u80bf\u7624\u90e8\u4f4d\u91ca\u653e\u963f\u9709\u7d20\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6b64\u5916\uff0c\u4f7f\u7528\u8102\u8d28\u4f53\u6216\u5176\u4ed6\u8102\u8d28\u57fa\u7eb3\u7c73\u9897\u7c92\u4f5c\u4e3a\u5c0f\u5e72\u6270RNA\u7684\u8f7d\u4f53\uff0c\u53ef\u4ee5\u514b\u670d\u56e0\u5176\u5728\u8840\u6db2\u4e2d\u7684\u4e0d\u7a33\u5b9a\u6027\u548c\u8d1f\u7535\u8377\u5bc6\u5ea6\u800c\u5bfc\u81f4\u7684\u4e34\u5e8a\u7528\u836f\u969c\u788d\uff0c\u8fd9\u662f\u4e00\u79cd\u5f88\u6709\u5e0c\u671b\u7684\u8fd0\u7528\u4e8e\u6cbb\u7597\u987d\u56fa\u6027\u75be\u75c5\u7684\u6b66\u5668\u3002\u73b0\u5df2\u8fdb\u884c\u4e86\u51e0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6765\u89c2\u5bdf\u5176\u7597\u6548\u548c\u526f\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u56e0\u6b64\uff0c\u5c3d\u7ba1FA\u548c\u80c6\u56fa\u9187\u4ee3\u8c22\u5728\u80bf\u7624\u76f8\u5173\u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u5f88\u91cd\u8981\uff0c\u4f46\u76f8\u5e94\u7684\u6cbb\u7597\u65b9\u6cd5\u4ecd\u7136\u7f3a\u4e4f\u3002\u7531\u4e8e\u8102\u8d28\u4ee3\u8c22\u5177\u6709\u660e\u663e\u7684\u5f71\u54cd\u5728\u4e0d\u540c\u7684\u80bf\u7624\u76f8\u5173\u7684\u514d\u75ab\u7ec6\u80de,\u751a\u81f3\u6709\u8d1f\u9762\u5f71\u54cd\u5728\u540c\u4e00\u7ec6\u80de\u7c7b\u578b\u7531\u4e8e\u6076\u6027\u80bf\u7624\u7684\u7c7b\u578b\u548c\u8102\u8d28,\u8fd9\u4e9b\u590d\u6742\u7684\u73b0\u8c61\u548c\u673a\u5236\u9700\u8981\u65b0\u9896\u7684\u6cbb\u7597\u7b56\u7565,\u76ee\u6807\u5728\u80bf\u7624\u76f8\u5173\u7684\u514d\u75ab\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u3002\u66f4\u5177\u4f53\u5730\u8bf4\uff0c\u9488\u5bf9\u4e0d\u540c\u6076\u6027\u80bf\u7624\u4e2d\u7279\u5b9a\u7684\u8102\u8d28\u4e9a\u578b\u3001\u9176\u548c\u514d\u75ab\u7ec6\u80de\u53ef\u80fd\u662f\u5f00\u53d1\u8102\u8d28\u76f8\u5173\u6297\u80bf\u7624\u836f\u7269\u7684\u4e00\u4e2a\u6709\u524d\u666f\u7684\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.8324074\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2022\/05\/wxsync-2022-05-e2955f6b507fe7199e40eb5bba2d5878.png\"  \/><\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row nowrap;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"text-align: justify;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;box-sizing: border-box;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: rgb(95, 156, 239);box-sizing: border-box;\">Table 2<\/span>&nbsp;<span style=\"box-sizing: border-box;\">\u80bf\u7624\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80de\u8102\u8d28\u4ee3\u8c22\u7684\u7b56\u7565<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: flex;flex-flow: row nowrap;margin: 20px 0% 10px;justify-content: flex-start;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;box-sizing: border-box;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u8102\u8d28\u4ee3\u8c22\u91cd\u7f16\u7a0b\u73b0\u5728\u88ab\u8ba4\u4e3a\u662f\u6076\u6027\u80bf\u7624\u7684\u4e00\u4e2a\u91cd\u8981\u7279\u5f81\u3002\u5728\u7f3a\u6c27\u3001\u9178\u6027\u548c\u8425\u517b\u7f3a\u4e4f\u7684TME\u4e2d\uff0c\u764c\u75c7\u548c\u514d\u75ab\u7ec6\u80de\u5f80\u5f80\u4f9d\u8d56\u8102\u8d28\u6765\u50a8\u5b58\u80fd\u91cf\u3001\u5f62\u6210\u7ec6\u80de\u819c\u7684\u7ec6\u80de\u6784\u5efa\u5757\u548c\u4fe1\u53f7\u5206\u5b50\u6765\u6e90\u3002\u56e0\u6b64\uff0cTME\u4e2d\u5f02\u5e38\u8c03\u8282\u7684\u8102\u8d28\u53ef\u663e\u8457\u5f71\u54cd\u80bf\u7624\u7684\u53d1\u751f\u3001\u540e\u7eed\u53d1\u5c55\u548c\u8f6c\u79fb\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u540c\u65f6\uff0cTME\u5185\u7684\u80bf\u7624\u76f8\u5173\u514d\u75ab\u7ec6\u80de\u4e5f\u53d7\u5230\u8fd9\u4e9b\u666e\u904d\u5b58\u5728\u7684\u8102\u8d28\u751f\u7269\u5206\u5b50\u7684\u5f71\u54cd\u3002TME\u4e2d\u7684\u80bf\u7624\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u6839\u636e\u5176\u5728\u80bf\u7624\u76f8\u5173\u514d\u75ab\u5e94\u7b54\u4e2d\u7684\u4f5c\u7528\u53ef\u5206\u4e3a\u6297\u80bf\u7624\u8868\u578b\u548c\u4fc3\u80bf\u7624\u8868\u578b\u3002\u5728TME\u4e2d\uff0c\u8102\u8d28\u662f\u4e00\u628a\u53cc\u5203\u5251\uff0c\u65e2\u652f\u6301\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4e5f\u652f\u6301\u4fc3\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4f8b\u5982\uff0c\u4fc3\u8fdbFAO\u53ef\u4ee5\u4e2d\u548cCD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u4e2dPD-1\u6297\u4f53\u7684\u6291\u5236\u4f5c\u7528\uff0c\u589e\u5f3aCD36\u8868\u8fbe\u6709\u52a9\u4e8e\u7ef4\u6301CD8<sup style=\"font-size: 12px;box-sizing: border-box;\">+<\/sup> T\u7ec6\u80de\u7684\u6709\u6548\u529f\u80fd\u548c\u957f\u671f\u751f\u5b58\u3002CAR-T\u7ec6\u80de\u4e2dFA\u4ee3\u8c22\u7684\u6539\u53d8\u53ef\u4ee5\u6539\u5584\u5176\u6297\u80bf\u7624\u514d\u75ab\u80fd\u529b\u3002\u4f46\u662f\uff0c\u4e5f\u6709\u62a5\u9053\u79f0\uff0c\u8fc7\u591a\u7684FAs\u4f1a\u6291\u5236TME\u4e2dTefs\u7684\u6297\u80bf\u7624\u80fd\u529b\uff0c\u652f\u6301Tregs\u7684\u589e\u6b96\u548c\u514d\u75ab\u6291\u5236\u529f\u80fd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: 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style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;box-sizing: border-box;\">\n<section style=\"color: rgb(0, 0, 0);box-sizing: border-box;\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u6211\u4eec\u7efc\u8ff0\u4e86\u5927\u91cf\u5173\u4e8eTME\u5185\u8102\u8d28\u4ee3\u8c22\u53ca\u5176\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u7684\u7814\u7a76\uff0c\u8fd9\u4e9b\u7814\u7a76\u5bf9\u591a\u79cd\u7c7b\u578b\u7684\u6076\u6027\u80bf\u7624\u4ea7\u751f\u4e86\u591a\u6837\u800c\u6df1\u523b\u7684\u5f71\u54cd\u3002\u7136\u800c\uff0c\u6709\u5173\u7684\u5177\u4f53\u673a\u5236\u4ecd\u6709\u5f85\u9610\u660e\u3002\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u57fa\u7840\u7814\u7a76\u548c\u836f\u7269\u5f00\u53d1\u6765\u9610\u660e\u8102\u8d28\u5728\u80bf\u7624\u514d\u75ab\u5b66\u4e2d\u7684\u4f5c\u7528\uff0c\u5e76\u4f18\u5316\u73b0\u6709\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);\"><span style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 12px;\">\u2014 THE &nbsp;END \u2014<\/span><\/p>\n<p style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);\"><br style=\"outline: 0px;\"  \/><\/p>\n<section style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u6765\u6e90&nbsp;|<\/span><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><\/span><span style=\"color: rgb(136, 136, 136);font-size: 12px;letter-spacing: 0.544px;\">Contradictory roles of lipid metabolism in immune response within the tumor microenvironment. J Hematol Oncol. 2021 Nov 6<\/span><\/section>\n<section style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u4f5c\u8005 |&nbsp;Weina Yu, Qingyang Lei, Li Yang,<\/span><\/section>\n<section style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">Guohui Qin, Shasha Liu, Dan Wang, Yu Ping and Yi Zhang<\/span><\/section>\n<section style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: 0.54px;\">\u7ffb\u8bd1&nbsp;|&nbsp;\u4efb\u632f\u9633 \u90d1\u68a6\u6021<\/span><\/section>\n<section style=\"white-space: normal;outline: 0px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 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!important;overflow-wrap: break-word !important;\">\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b&nbsp;<\/span><\/section>\n<section style=\"margin-right: 8px;margin-left: 8px;outline: 0px;max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;line-height: 2em;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"outline: 0px;max-width: 100%;font-size: 15px;background-color: rgb(249, 237, 166);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/section>\n<blockquote>\n<p>\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:                 OncoLab              <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8ba8\u8bba\u4ea4\u6d41\u53caPDF\u4e0b\u8f7d\u53ef\u79fb\u6b65OncoLab\u5b66\u672f\u661f\u7403~ 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