{"id":2575,"date":"2022-05-22T11:47:48","date_gmt":"2022-05-22T03:47:48","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2022\/05\/22\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac9%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%9d%80%e4%bc%a4%e7%bb%86%e8%83%9e%e4%bb%a5%e5%8f%8a%e5%85%b6%e5%ae%83%e5%9b%ba%e6%9c%89%e6%b7%8b%e5%b7%b4\/"},"modified":"2022-05-22T11:47:48","modified_gmt":"2022-05-22T03:47:48","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac9%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%9d%80%e4%bc%a4%e7%bb%86%e8%83%9e%e4%bb%a5%e5%8f%8a%e5%85%b6%e5%ae%83%e5%9b%ba%e6%9c%89%e6%b7%8b%e5%b7%b4","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2022\/05\/22\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac9%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%9d%80%e4%bc%a4%e7%bb%86%e8%83%9e%e4%bb%a5%e5%8f%8a%e5%85%b6%e5%ae%83%e5%9b%ba%e6%9c%89%e6%b7%8b%e5%b7%b4\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c9\u7ae0\uff1a\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4ee5\u53ca\u5176\u5b83\u56fa\u6709\u6dcb\u5df4\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u76d1\u89c6\u4f5c\u7528\uff08\u4e0a)"},"content":{"rendered":"
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9.1 \u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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T\u7ec6\u80de\u80fd\u8bc6\u522b\u4f53\u5185\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC)\u5206\u5b50\u4e0a\u7684\u6297\u539f\uff0c\u5e76\u4e14\u4ea7\u751f\u9488\u5bf9\u80bf\u7624\u7684\u7279\u5f02\u6027\u53cd\u5e94\uff0c\u56e0\u6b64T\u7ec6\u80de\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528<\/strong>\u3002\u4e8b\u5b9e\u4e0a\uff0c\u80bf\u7624\u6d78\u6da6\u7684\u7ec6\u80de\u6bd2\u6027CD8+<\/sup>T\u7ec6\u80de\u548cTh1\u6781\u5316\u7684CD4+<\/sup>T\u7ec6\u80de\u901a\u5e38\u4e0e\u8f83\u597d\u7684\u9884\u540e\u6709\u5173\uff0c\u4f46\u5e38\u89c4\u7684T\u7ec6\u80de\u5e76\u4e0d\u662f\u6297\u764c\u514d\u75ab\u7684\u552f\u4e00\u4ecb\u8d28\u3002<\/strong><\/p>\n

\u5c3d\u7ba1\u4e00\u4e9b\u514d\u75ab\u7ec6\u80de\u7f3a\u4e4f\u6297\u539f\u80bd\u7684\u7279\u5f02\u6027\u53d7\u4f53\uff0c\u4f46\u4ecd\u80fd\u68c0\u6d4b\u5230\u80bf\u7624\u6076\u6027\u8f6c\u5316\u7684\u6700\u65e9\u8ff9\u8c61\u3002\u5176\u4e2d\u6fc0\u6d3b\u673a\u4f53\u5148\u5929\u514d\u75ab\u7ec6\u80de\u53ef\u5373\u65f6\u63d0\u4f9b\u4fdd\u62a4\uff0c\u56e0\u6b64\u5148\u5929\u514d\u75ab\u7ec6\u80de\u5f88\u53ef\u80fd\u5728\u80bf\u7624\u7684\u65e9\u671f\u9636\u6bb5\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002<\/strong>\u764c\u75c7\u7684\u5148\u5929\u514d\u75ab\u76d1\u6d4b\u6d89\u53ca\u9aa8\u9ad3\u7ec6\u80de\uff0c\u5982\u5de8\u566c\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u643a\u5e26T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7684\u975e\u5e38\u89c4T\u7ec6\u80de\uff0c\u5982\u81ea\u7136\u6740\u4f24T\uff08NKT\uff09\u7ec6\u80de\u548c\u03b3\u03b4T\u7ec6\u80de<\/strong>\uff1b\u4ee5\u53ca\u4e00\u4e2a\u4e0d\u65ad\u589e\u957f\u7684\u6dcb\u5df4\u7ec6\u80de\u5bb6\u65cf\uff0c\u79f0\u4e3a\u5148\u5929\u6dcb\u5df4\u7ec6\u80de\uff08ILC\uff09<\/strong>\u3002 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5148\u5929\u6dcb\u5df4\u6837\u7ec6\u80de\u7684\u7279\u70b9\u662f\u6dcb\u5df4\u6837\u5f62\u6001<\/strong>\u3001\u7f3a\u4e4f RAG \u91cd\u6392\u7684\u6297\u539f\u7279\u5f02\u6027\u53d7\u4f53<\/strong>\u4ee5\u53ca\u7f3a\u4e4f\u6811\u7a81\u6216\u9ad3\u7cfb\u8c31\u7cfb\u7684\u8868\u9762\u6807\u5fd7\u7269<\/strong>\u3002ILC\u5305\u62ec\u5177\u6709\u5171\u540c\u6765\u6e90\u7684\u5f02\u8d28\u7ec6\u80de\u7fa4\u4f53\u3002\u5b83\u4eec\u88ab\u5206\u4e3a\u6740\u4f24\uff08\u7834\u574f\uff09\u578b\u548c\u8f85\u52a9\u578bILC\uff08Fig. 9.1<\/span>\uff09\u3002<\/p>\n

\u81ea\u7136\u6740\u4f24(NK)\u7ec6\u80de<\/strong>\u662fILC\u5bb6\u65cf\u4e2d\u6700\u5178\u578b\u7684\u7ec6\u80de\u6bd2\u6027\u7ec6\u80de\u3002\u6740\u4f24\u578bILC<\/strong>\u5177\u6709\u4e0eCD8+<\/sup>\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u76f8\u4f3c\u7684\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u548c\u5185\u5bb9\u7269\u3002\u800c\u8f85\u52a9\u578bILC<\/strong>\u53ef\u4ee5\u53cd\u6620CD4+<\/sup>\u8f85\u52a9T\u7ec6\u80de\u7684\u6d3b\u6027\u3002<\/p>\n

\u6b64\u5916\uff0c\u6839\u636eILC\u7ec6\u80de\u56e0\u5b50\u7684\u8868\u8fbe\u8c31\u4ee5\u53ca\u5bf9\u7279\u5f02\u6027\u8f6c\u5f55\u56e0\u5b50\u7684\u9700\u6c42\uff0cILC\u53ef\u88ab\u5206\u4e3a3\u7c7b<\/strong>\u3002<\/p>\n

\u7b2c1\u7c7b<\/strong> ILC\u4f9d\u8d56\u4e8eTh1\u7ec6\u80de\u76f8\u5173\u7684\u8f6c\u5f55\u56e0\u5b50T-bet\uff0c\u53ef\u4ee5\u91ca\u653e\u5e72\u6270\u7d20\u03b3\u3002\u8fd9\u7c7b\u7ec6\u80de\u5305\u62ecNK\u7ec6\u80de<\/strong>\u548c\u8f85\u52a9\u578b1\u578bILC1(ILC1)<\/strong>\uff0c\u867d\u7136NK\u7ec6\u80de\u548cILC1\u5728\u53d1\u80b2\u4e0a\u662f\u622a\u7136\u4e0d\u540c\u7684\uff0c\u4f46\u5b83\u4eec\u6709\u8bb8\u591a\u5171\u540c\u7684\u8868\u9762\u6807\u8bb0\uff0c\u6240\u4ee5\u8fd9\u4e24\u79cd\u5148\u5929\u7ec6\u80de\u7fa4\u4f53\u901a\u5e38\u4e0d\u6613\u533a\u5206\u3002\u9664\u553e\u6db2\u817aILC1\u5916\uff0cNK\u7ec6\u80de\u533a\u522b\u4e8eILC1\u7684\u6807\u5fd7\u662f\u8f6c\u5f55\u56e0\u5b50Eomes\u7684\u8868\u8fbe<\/strong>\u3002<\/p>\n

\u7b2c2\u7c7b<\/strong>ILC\u7684\u53d1\u80b2\u548c\u529f\u80fd\u4f9d\u8d56\u4e8e\u8f6c\u5f55\u56e0\u5b50GATA3<\/strong>\u548cRoR\u03b1<\/strong>\uff0c\u5e76\u53ef\u4ee5\u91ca\u653e2\u578b\u7ec6\u80de\u56e0\u5b50\uff08\u4e3b\u8981\u662fIL-5<\/strong>\u548cIL-13<\/strong>\uff09\u3002<\/p>\n

\u6700\u540e\uff0c\u7b2c3\u7c7b<\/strong> ILC\u7684\u53d1\u80b2\u548c\u529f\u80fd\u662f\u6839\u636e\u5b83\u4eec\u4ea7\u751fIL-17<\/strong>\u548cIL-22<\/strong>\u7684\u80fd\u529b\u4ee5\u53ca\u5b83\u4eec\u5bf9\u8f6c\u5f55\u56e0\u5b50RoR\u03b3t<\/strong>\u7684\u4f9d\u8d56\u6027\u6765\u5224\u65ad\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 9.1 <\/span> ILC\u5bb6\u65cf\u6210\u5458\u53ca\u5176\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u3002ILC\u5bb6\u65cf\u5305\u62ec\u6740\u4f24\u578bILC\u548c\u8f85\u52a9\u578bILC\u3002ILC\u6839\u636e\u5176\u6807\u5fd7\u6027\u7ec6\u80de\u56e0\u5b50\u548c\u8f6c\u5f55\u56e0\u5b50\u7684\u4f9d\u8d56\u6027\u88ab\u8fdb\u4e00\u6b65\u5206\u4e3a\u4e09\u7c7b\u3002\u672c\u6587\u4ecb\u7ecd\u4e86\u8fd9\u4e09\u7c7bILC\u7684\u4e3b\u8981\u7279\u6027\u4ee5\u53ca\u5b83\u4eec\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u95ee\u53f7(\uff1f)\u6307\u5c1a\u672a\u8868\u73b0\u51fa\u7684\u53ef\u80fd\u7684\u4f5c\u7528\u3002NK \u7ec6\u80de\u76f4\u63a5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u5df2\u5f97\u5230\u5145\u5206\u8bc1\u5b9e\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u7814\u7a76\u901a\u8fc7\u88c2\u89e3\u9897\u7c92\u9014\u5f84\u6216\u5728\u809d\u810f ILC1 \u7684\u60c5\u51b5\u4e0b\u901a\u8fc7 TRAIL \u63cf\u8ff0\u4e86 ILC1 \u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de<\/strong>\u662f\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684ILC\u4e9a\u7fa4<\/strong>\uff0c\u6700\u521d\u88ab\u9274\u5b9a\u4e3a\u5177\u6709\u81ea\u53d1\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002NK\u7ec6\u80de\u901a\u5e38\u88ab\u79f0\u4e3aCD3\u9634\u6027\u7ec6\u80de<\/strong>\uff0c\u5728\u4eba\u7c7b\u4e2d\u8868\u8fbeCD56<\/strong>\uff0c\u5728\u5c0f\u9f20\u4e2d\u8868\u8fbeNK1.1<\/strong>\uff0c\u5728\u4e24\u79cd\u7269\u79cd\u4e2d\u90fd\u8868\u8fbeNKp46<\/strong>\u3002\u8fd9\u79cd\u5bf9NK\u7ec6\u80de\u7684\u8868\u578b\u5b9a\u4e49\u540c\u6837\u9002\u7528\u4e8e\u4e00\u4e9b\u5176\u4ed6\u7684ILC\u4e9a\u7fa4\u3002<\/p>\n

\u6b64\u5916\uff0cNK\u7ec6\u80de\u8fd8\u53ef\u4ee5\u5206\u4e3a\u4e0d\u540c\u7684\u4e9a\u578b<\/strong>\u3002\u5728\u4eba\u7c7b\u4e2d\uff0c\u4e24\u4e2a\u4e3b\u8981\u7684NK\u7ec6\u80de\u4e9a\u578b\u662fCD56bright<\/sup>CD16\u2212<\/sup>NK\u7ec6\u80de<\/strong>\u548cCD56dim<\/sup>CD16+<\/sup>NK\u7ec6\u80de<\/strong>\uff0cCD56bright<\/sup>CD16\u2212<\/sup>NK\u7ec6\u80de\u662f\u91cd\u8981\u7684\u7ec6\u80de\u56e0\u5b50\u751f\u4ea7\u8005<\/strong>\uff0c\u5728\u6dcb\u5df4\u7ed3\u4e2d\u542b\u91cf\u4e30\u5bcc\uff1bCD56dim<\/sup>CD16+<\/sup>NK\u7ec6\u80de\u662f\u8840\u6db2\u4e2d\u4e3b\u8981\u7684NK\u7ec6\u80de\u7fa4\uff0c\u5177\u6709\u9ad8\u7ec6\u80de\u6bd2\u6027<\/strong>\u3002NK\u7ec6\u80de\u8017\u7aed\u6297\u4f53\u4ee5\u53caNK\u7ec6\u80de\u7f3a\u9677\u7684\u5c0f\u9f20\u6a21\u578b\u662f\u8bc1\u660eNK\u7ec6\u80de\u6297\u764c\u6d3b\u6027\u7684\u57fa\u7840(Table 9.1<\/span>)\u3002<\/p>\n

NK\u7ec6\u80de\u4e2d\u8bb8\u591a\u8868\u9762\u53d7\u4f53<\/strong>\u80fd\u591f\u533a\u5206\u764c\u53d8\u7684\u7ec6\u80de\u548c\u6b63\u5e38\u7ec6\u80de<\/strong>\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u4e0d\u4ec5\u5177\u6709\u5f3a\u5927\u7684\u7ec6\u80de\u6bd2\u6027\u529f\u80fd<\/strong>\uff0c\u800c\u4e14\u8fd8\u662f\u6297\u80bf\u7624\u7ec6\u80de\u56e0\u5b50\u5e72\u6270\u7d20-\u03b3<\/strong>\u7684\u4e3b\u8981\u6765\u6e90\u3002\u8fd9\u4e9b\u7279\u6027\u4f7fNK\u7ec6\u80de\u5728\u673a\u4f53\u5bf9\u764c\u75c7\u7684\u5148\u5929\u514d\u75ab\u68c0\u6d4b<\/strong>\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u4e0e\u5927\u91cf\u5173\u4e8e\u764c\u75c7\u4e2d NK \u7ec6\u80de\u7684\u62a5\u9053\u5b8c\u5168\u76f8\u53cd\uff0c\u8f85\u52a9\u578b ILC<\/strong> \u53ef\u80fd\u7684\u4fc3\u80bf\u7624\u6216\u6297\u80bf\u7624\u529f\u80fd\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u4ecd\u672a\u5f97\u5230\u63a2\u7d22\u3002\u6700\u8fd1\u4ecd\u6709\u7814\u7a76\u8868\u660e\u7ec4\u7ec7\u4e2d\u76841\u7c7bILC\u53c2\u4e0e\u4e86\u81ea\u53d1\u6027\u80bf\u7624\u7684\u514d\u75ab\u76d1\u6d4b\u3002\u6b64\u5916\uff0c\u5176\u4ed6\u5404\u79cd\u62a5\u9053\u4e5f\u9610\u8ff0\u4e86ILC2s\u548cILC3s\u7684\u6291\u7624\u6d3b\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 9.1<\/span>  \u7528\u4e8e\u7814\u7a76NK\u7ec6\u80de\u529f\u80fd\u7684\u5c0f\u9f20\u6a21\u578b\u548c\u8017\u7aed\u6297\u4f53<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u672c\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u56de\u987eILC\u68c0\u6d4b\u6076\u6027\uff08\u80bf\u7624\uff09\u7ec6\u80de\u548c\u9884\u9632\u764c\u75c7\u53d1\u5c55\u7684\u4e0d\u540c\u673a\u5236<\/strong>\u3002\u6211\u4eec\u76ee\u524d\u7684\u8ba4\u8bc6\u5927\u591a\u5c40\u9650\u4e8e\u6784\u6210\u4e86\u5178\u578b\u7684\u8f85\u52a9\u578b\u6297\u764cILC\u4e9a\u7fa4\u7684NK\u7ec6\u80de\u3002\u56e0\u6b64\u672c\u7ae0\u6211\u4eec\u5c06\u4e3b\u8981\u5173\u6ce8NK\u7ec6\u80de<\/strong>\uff0c\u540c\u65f6\u4e5f\u4f1a\u4ecb\u7ecd\u6709\u5173ILC\u7684\u6700\u65b0\u7814\u7a76\u3002\u867d\u7136\u76ee\u524d\u5df2\u6709\u76f8\u5173\u7814\u7a76\u8bc1\u660e\u8f85\u52a9\u578bILC\u7684\u4fc3\u80bf\u7624\u548c\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4f46\u5728\u8fd9\u91cc\u6211\u4eec\u53ea\u8ba8\u8bba\u5b83\u4eec\u6f5c\u5728\u7684\u5bbf\u4e3b\u4fdd\u62a4\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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9.2 \u8868\u9762\u53d7\u4f53\u53c2\u4e0eILC\u5bf9\u80bf\u7624\u7684\u8bc6\u522b<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u56fa\u6709\u7ec6\u80de<\/strong>\u8868\u8fbe\u4e00\u7ec4\u56fa\u5b9a\u7684\u79cd\u7cfb\u7f16\u7801\u53d7\u4f53<\/strong>\uff0c\u8fd9\u7ec4\u53d7\u4f53\u53ef\u4ee5\u8bc6\u522b\u5916\u6765\u3001\u8001\u5316\u548c\u53d7\u635f\u7684\u7ec6\u80de<\/strong>\uff0c\u6240\u4ee5\u6fc0\u6d3b\u548c\u6291\u5236\u8868\u9762\u53d7\u4f53\u5bf9\u4e8e\u8c03\u8282NK\u7ec6\u80de\u7684\u529f\u80fd\u81f3\u5173\u91cd\u8981\uff0c\u5176\u4e2d\u4e00\u4e9b\u53d7\u4f53\u4e5f\u4f1a\u5728\u8f85\u52a9\u578bILC\u4e9a\u7fa4\u4e0a\u8868\u8fbe(Fig. 9.2<\/span>)\u3002<\/p>\n

\u6b64\u5916\uff0c\u4e0e\u8f85\u52a9\u7ec6\u80de<\/strong>(\u901a\u5e38\u662f\u5355\u6838\u7ec6\u80de\u6216\u6811\u7a81\u72b6\u7ec6\u80de(DC)<\/strong>)\u7684\u76f8\u4e92\u4f5c\u7528\u4e5f\u80fd\u523a\u6fc0NK\u7ec6\u80de\u4ea7\u751f\u4fc3\u708e\u56e0\u5b50\u5e76\u589e\u5f3a\u5176\u6740\u4f24\u529f\u80fd\u3002\u7814\u7a76\u8bc1\u660e\uff0cNK\u7ec6\u80de\u80fd\u591f\u6740\u6b7b\u4e0b\u8c03MHC-I\u7c7b\u5206\u5b50<\/strong>(MHC-I)\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u8fd9\u4e00\u4f5c\u7528\u673a\u5236\u88ab\u79f0\u4e3a\u201c\u4e22\u5931\u81ea\u6211\u201d\u8bc6\u522b<\/strong>\u3002<\/p>\n

\u5927\u591a\u6570\u7ec6\u80de\u7c7b\u578b<\/strong>\u8868\u9762\u4f1a\u8868\u8fbe\u81ea\u8eab\u591a\u80bd-MHC-I\u590d\u5408\u7269\uff0c\u4f46\u5927\u90e8\u5206\u764c\u7ec6\u80de<\/strong>\u7684MHC-I\u8868\u8fbe\u4f1a\u51fa\u73b0\u90e8\u5206\u6216\u5168\u90e8\u4e27\u5931<\/strong>\uff0c\u8fd9\u79cdMHC-I\u8868\u8fbe\u7684\u90e8\u5206\u6216\u5168\u90e8\u4e27\u5931\u73b0\u8c61\u901a\u5e38\u662f\u7531CD8+<\/sup>T\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u5f15\u8d77\u7684\uff0c\u5b83\u540c\u65f6\u4f1a\u4f7f\u80bf\u7624\u7ec6\u80de\u5bf9NK\u7ec6\u80de<\/strong>\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u53d8\u5f97\u66f4\u52a0\u654f\u611f<\/strong>\u3002\u800c\u6b63\u5e38\u7ec6\u80de\u4e0d\u4f1a\u5f15\u8d77NK\u7ec6\u80de\u7684\u81ea\u8eab\u53cd\u5e94\uff0c\u662f\u56e0\u4e3a\u5728\u6b63\u5e38\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684MHC-I\u5206\u5b50\u4f1a\u4e0e\u6291\u5236\u6027NK\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408<\/strong>\u5e76\u4f20\u9012\u8d1f\u4fe1\u53f7\uff0c\u4ece\u800c\u907f\u514dNK\u7ec6\u80de\u7684\u81ea\u8eab\u53cd\u5e94\u3002<\/p>\n

\u9664\u4e86\u201c\u4e22\u5931\u81ea\u6211\u201d\u7684\u8bc6\u522b\u5916\uff0c\u68c0\u6d4b\u53d7\u635f\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684\u81ea\u8eab\u914d\u4f53\u4e5f\u80fd\u63d0\u9ad8NK\u7ec6\u80de\u7684\u6740\u4f24\u80fd\u529b\u3002\u4e8b\u5b9e\u4e0a\uff0cNK\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c<\/strong>\u53d6\u51b3\u4e8eNK\u7ec6\u80de\u53d7\u4f53\u4e0e\u9776\u7ec6\u80de\u81ea\u8eabMHC-I\u7ed3\u5408\u4f20\u9012\u7684\u6291\u5236\u4fe1\u53f7<\/strong>\u548c\u5176\u8bc6\u522b\u9776\u7ec6\u80de\u8868\u9762\u5e94\u6fc0\u914d\u4f53\u65f6\u4f20\u9012\u7684\u6fc0\u6d3b\u4fe1\u53f7<\/strong>\u4e4b\u95f4\u7684\u5e73\u8861<\/strong>\u3002<\/p>\n

\u6fc0\u6d3b<\/strong>\u53c2\u4e0e\u80bf\u7624\u514d\u75ab\u76d1\u89c6\u7684NK\u7ec6\u80de\u7684\u53d7\u4f53\u5305\u62ec\u56fa\u6709\u7ec6\u80de\u6bd2\u6027\u53d7\u4f53(NCRs<\/strong>)\u3001NKG2D<\/strong>(\u4e5f\u79f0\u4e3aCD314\u548cKLRK1)\u548cDNAM-1<\/strong>(\u4e5f\u79f0\u4e3aCD226)\uff1b\u4ee5\u53ca\u5176\u4ed6\u53d7\u4f53\u5982\u4f4e\u4eb2\u548c\u529b\u7684\u6fc0\u6d3b\u53d7\u4f53Fc\u03b3RIIIa(CD16)<\/strong>\/\u5171\u523a\u6fc0\u5206\u5b50CD137<\/strong>, OX40<\/strong>\u548cGITR<\/strong>\u90fd\u5177\u6709\u5f3a\u5927\u7684\u4ecb\u5bfcNK\u7ec6\u80de\u6fc0\u6d3b<\/strong>\u7684\u80fd\u529b\uff0c\u56e0\u6b64\u5f88\u6709\u5e0c\u671b\u5c06\u5176\u8fd0\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u7684\u9776\u70b9\u3002\u4f46\u73b0\u5728\u4ecd\u6ca1\u6709\u4efb\u4f55\u76f8\u5173\u62a5\u9053\u80fd\u8bc1\u660e\u8fd9\u4e9b\u53d7\u4f53\u5728\u65b0\u751f\u80bf\u7624\u7684\u65e9\u671f\u68c0\u6d4b\u4e2d\u7684\u4f5c\u7528\uff0c\u56e0\u6b64\u8fd9\u91cc\u4e0d\u518d\u8ba8\u8bba\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig. 9.2<\/span> \u7ec6\u80de\u8868\u9762\u53d7\u4f53\u53c2\u4e0eILC\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u3002NK\u7ec6\u80de\u8868\u8fbe\u4e00\u7cfb\u5217\u6fc0\u6d3b(\u7eff\u8272)\u6216\u6291\u5236(\u7ea2\u8272)\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u3002\u6709\u4e9b\u53d7\u4f53\u53ea\u5728\u6fc0\u6d3b\u7684NK\u7ec6\u80de\u4e0a\u8868\u8fbe(\u4e0b\u5212\u7ebf)\u3002NK\u7ec6\u80de\u4e0e\u9776\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\u53d6\u51b3\u4e8e\u6fc0\u6d3b\u548c\u6291\u5236\u4fe1\u53f7\u4e4b\u95f4\u7684\u5e73\u8861\u3002\u6b63\u5e38\u7ec6\u80de\u53ef\u4ee5\u8868\u8fbe\u4e0eNK\u7ec6\u80de\u6291\u5236\u53d7\u4f53\u7ed3\u5408\u7684MHC-I\u5206\u5b50\uff0c\u800c\u764c\u7ec6\u80de\u53ef\u4e0b\u8c03MHC-I\u5206\u5b50\u548c\/\u6216\u8868\u8fbeNK\u7ec6\u80de\u6fc0\u6d3b\u53d7\u4f53\u8bc6\u522b\u7684\u5e94\u6fc0\u914d\u4f53\u3002\u6fc0\u6d3b\u4fe1\u53f7\u8d85\u8fc7\u6291\u5236\u4fe1\u53f7\u4f1a\u5bfc\u81f4NK\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u9776\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u3002\u6700\u8fd1\u7814\u7a76\u53d1\u73b0DNAM-1\u548cPD-1\u5728\u5c0f\u9f20ILCs\u4e0a\u7684\u8868\u8fbe\uff0c\u4f46\u5c1a\u672a\u7814\u7a76\u5176\u5728\u4ebaILC\u4e0a\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

NCR\u5bb6\u65cf<\/strong>\u6709\u4e09\u4e2a\u6210\u5458<\/strong>\uff1aNKp46(NCR1\uff1bCD335)\u5728\u5c0f\u9f20\u548c\u4eba\u4e2d\u90fd\u6709\u8868\u8fbe\uff0c\u800cNKp44(NCR2\uff0cCD336)\u548cNKp30(NCR3\uff1bCD337)\u4ec5\u8868\u8fbe\u4e8e\u4eba\u7684NK\u7ec6\u80de\u3002\u4e0eNKp46\u548cNKp30\u4e0d\u540c\u7684\u662f\uff0cNKp44\u5728\u9759\u606fNK\u7ec6\u80de\u4e0a\u68c0\u6d4b\u4e0d\u5230\uff0c\u4f46\u5728\u6fc0\u6d3b\u540e\u7684NK\u7ec6\u80de\u4e0a\u8868\u8fbe\u4e0a\u8c03\u3002<\/p>\n

NCR<\/strong>\u53c2\u4e0e\u89e6\u53d1NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027<\/strong>\u548c\u5e72\u6270\u7d20\u03b3\u7684\u5206\u6ccc<\/strong>\u3002\u91cd\u8981\u7684\u662f\uff0cNCR\u7684\u8868\u8fbe\u4e0d\u4ec5\u4ec5\u9650\u4e8eNK\u7ec6\u80de\uff0c\u5728\u8f85\u52a9\u578bILC1s\u3001\u4eba\u7c7bILC2s\u4ee5\u53ca\u540d\u4e3aNCR+<\/sup>ILC3s\u7684ILC3s\u4e2d\u4e5f\u6709\u8868\u8fbe\uff0c\u80bf\u7624\u7ec6\u80de\u548c\u80bf\u7624\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u7ed3\u5408NKp44\u53ef\u4ee5\u523a\u6fc0NCR+<\/sup>ILC3\u91ca\u653eIL-8\u548cTNF\u3002\u540c\u6837\uff0cNKp30\u4ecb\u5bfc\u7684\u4eba\u7c7b\u80bf\u7624\u7ec6\u80de\u7684\u8bc6\u522b\u8bf1\u5bfcILC2\u4e2dNF-\u03baB\u4fe1\u53f7\u901a\u8def\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u4fc3\u8fdbIL-13\u548c\u5176\u4ed62\u578b\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u4f46\u662f\uff0cNCR\u5bf9\u6076\u6027\u7ec6\u80de\u7684\u8f85\u52a9\u578bILC1\u8bc6\u522b\u7684\u8c03\u63a7\u4f5c\u7528\u8fd8\u6709\u5f85\u8bc1\u5b9e\u3002<\/p>\n

\u76ee\u524d\u4ec5\u6709\u90e8\u5206\u7814\u7a76\u660e\u786e\u62a5\u9053\u4e86\u80bf\u7624\u7ec6\u80de\u4e0a\u7684NCR\u914d\u4f53<\/strong>\uff0c\u5176\u4e2d\u5305\u62ecNKp44L\u3001HLA-B\u76f8\u5173\u8f6c\u5f55\u672c3(BAT3)\u3001B7-H6\u3001\u786b\u9178\u4e59\u9170\u809d\u7d20\u548c\u589e\u6b96\u7ec6\u80de\u6838\u6297\u539f(PCNA)\u3002\u5947\u602a\u7684\u662f\uff0cPCNA\u4e0d\u540c\u4e8e\u5176\u4ed6NCR\u914d\u4f53\uff0c\u5b83\u901a\u8fc7\u6291\u5236NK\u7ec6\u80de\u529f\u80fd\u6765\u53d1\u6325\u4f5c\u7528\u3002\u6b64\u5916\uff0cNCR\u57fa\u56e0\u7f16\u7801\u4e0d\u540c\u7684\u526a\u63a5\u53d8\u4f53\uff0c\u5176\u4e2d\u4e00\u4e9b\u662f\u8d77\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684\u3002<\/p>\n

\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u56e0\u5b50\u5b9a\u4e49\u7684\u5fae\u73af\u5883<\/strong>\u53ef\u80fd\u4f1a\u5f71\u54cdNK\u7ec6\u80de\u4e2dNKp30\u548cNKp44\u4e9a\u578b\u7684\u8868\u8fbe\u8c31\uff0c\u800c\u57fa\u56e0\u7f16\u7801\u7684\u9009\u62e9\u6027\u526a\u63a5\u4f1a\u5bfc\u81f4\u6291\u5236\u4e9a\u578b\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u6291\u5236NK\u7ec6\u80de\u7684\u529f\u80fd\u3002<\/p>\n

\u6b64\u5916\uff0c\u5728\u80c3\u80a0\u9053\u95f4\u8d28\u7624<\/strong>\u4e2d\uff0c\u514d\u75ab\u6291\u5236\u7684NKp30c\u4e9a\u578b\u7684\u8868\u8fbe\u660e\u663e\u9ad8\u4e8e\u514d\u75ab\u523a\u6fc0\u7684NKp30a\u548cNKp30b\u4e9a\u578b\u7684\u8868\u8fbe\uff0c\u5e76\u4e14\u4e0e\u751f\u5b58\u7387\u964d\u4f4e\u76f8\u5173\u3002\u7f3a\u4e4fNKp46\u7684\u5c0f\u9f20\u53ef\u7528\u4e8e\u786e\u5b9aNKp46\u5728\u4f53\u5185\u63a7\u5236\u80bf\u7624\u521d\u59cb\u751f\u957f\u548c\u5728\u9884\u9632\u80bf\u7624\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528\u3002\u4f46\u7531\u4e8e\u7f3a\u4e4fNKp30\u548cNKp44\u7684\u5c0f\u9f20\u540c\u6e90\u7269\uff0c\u5176\u4ed6NCR\u5728\u80bf\u7624\u514d\u75ab\u76d1\u6d4b\u4e2d\u7684\u4f53\u5185\u7814\u7a76\u53d7\u5230\u9650\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NKG2D<\/strong>\u662f\u4e3b\u8981NK\u7ec6\u80de\u6fc0\u6d3b\u53d7\u4f53<\/strong>\u4e4b\u4e00\uff0c\u67d0\u4e9bT\u7ec6\u80de\u4e9a\u7fa4\u4e5f\u8868\u8fbeNKG2D\u3002NKG2D\u53ef\u8bc6\u522b\u51e0\u79cd\u4e0eMHC\u76f8\u5173\u7684\u914d\u4f53\uff0c\u8fd9\u4e9b\u914d\u4f53<\/strong>\u5728\u6b63\u5e38\u7ec6\u80de<\/strong>\u8868\u9762\u8868\u8fbe\u5f88\u4f4e<\/strong>\uff0c\u4f46\u5728\u6076\u53d8\u7ec6\u80de<\/strong>\u4e2d\u8868\u8fbe\u8f83\u9ad8<\/strong>\u3002\u4f8b\u5982\uff0c\u5728\u672a\u8f6c\u5316\u7684\u5c0f\u9f20\u6216\u4eba\u7c7b\u7ec6\u80de\u4e2d\uff0cDNA\u635f\u4f24\u53cd\u5e94\u7684\u6fc0\u6d3b\u4f1a\u8bf1\u5bfcNKG2D\u914d\u4f53\u7684\u4e0a\u8c03\uff0c\u5e76\u589e\u5f3a\u7ec6\u80de\u5bf9NK\u7ec6\u80de\u6740\u4f24\u7684\u654f\u611f\u6027\u3002<\/p>\n

\u5c0f\u9f20\u4e2dNKG2D\u914d\u4f53<\/strong>\u662fRAE-1\u03b1-\u025b<\/strong>\u3001MULT1<\/strong>\u548cH60a-c<\/strong>\uff0c\u5728\u4eba\u7c7b\u4e2d\u5219\u662fMICA-B<\/strong>\u548cULBP1-6<\/strong>\u3002NKG2D \u53c2\u4e0e\u523a\u6fc0\u4fe1\u53f7\u7ea7\u8054\u53cd\u5e94\uff0c\u5bfc\u81f4\u7ec6\u80de\u6d3b\u5316\u3001\u6740\u4f24\u548c\u7ec6\u80de\u56e0\u5b50\u4ea7\u751f\u3002<\/p>\n

\u4e00\u9879\u5f00\u521b\u6027\u7684\u7814\u7a76\u8868\u660e\uff0c\u7ecf\u8fc7\u5de5\u7a0b\u6539\u9020\u4ee5\u8868\u8fbe\u9ad8\u6c34\u5e73 NKG2D \u914d\u4f53\u5e76\u76ae\u4e0b\u6ce8\u5c04\u5230\u540c\u7cfb\u5c0f\u9f20\u4e2d\u7684\u5c0f\u9f20\u80bf\u7624\u7ec6\u80de\u7cfb\u88ab\u5e38\u89c4 NK \u7ec6\u80de\u8fc5\u901f\u6392\u65a5\uff0c\u800c\u65e0\u9700 T \u7ec6\u80de\u548c B \u7ec6\u80de\u3002\u5c06\u8868\u8fbe\u9ad8\u6c34\u5e73NKG2D\u914d\u4f53\u7684\u5c0f\u9f20\u80bf\u7624\u7ec6\u80de\u7cfb\uff0c\u76ae\u4e0b\u6ce8\u5c04\u5230\u540c\u57fa\u56e0\u5c0f\u9f20\u540e\uff0c\u4e0d\u9700\u8981T\u7ec6\u80de\u548cB\u7ec6\u80de\uff0cNK\u7ec6\u80de\u5c31\u80fd\u8fc5\u901f\u6392\u65a5\u8be5\u80bf\u7624\u7ec6\u80de\u7cfb\u3002<\/span><\/p>\n

\u6b64\u5916\uff0c\u5728\u53d1\u751f\u80bf\u7624<\/strong>\u548c\u764c\u53d8\u7684\u5c0f\u9f20\u6a21\u578b<\/strong>\u4e2d\u90fd\u8bc1\u5b9e\u4e86NKG2D\u5728\u80bf\u7624\u514d\u75ab\u76d1\u63a7\u4e2d\u7684\u5173\u952e\u4f5c\u7528<\/strong>\u3002\u5728\u5c0f\u9f20B\u7ec6\u80de<\/span>\u4e2d\u8868\u8fbeEpstein-Barr\u75c5\u6bd2\u8f6c\u5316\u86cb\u767dLPM1\u5bfc\u81f4B\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u6a21\u578b\u4e2d\uff0c\u6dcb\u5df4\u7624\u7ec6\u80de\u8868\u8fbeNKG2D\u7684\u914d\u4f53\uff0c\u5e76\u5728\u4f53\u5916\u80fd\u88abNK\u7ec6\u80de\u6740\u4f24\u3002\u5728\u8fd9\u4e2a\u6a21\u578b\u4e2d\uff0cT\u7ec6\u80de\u662f\u514d\u75ab\u76d1\u89c6\u7684\u4e3b\u8981\u6548\u5e94\u8005\u3002<\/p>\n

\u5728\u4f53\u5185\uff0c\u6dcb\u5df4\u7624\u7684\u53d1\u751f\u53ef\u80fd\u6d89\u53ca\u9003\u907fNK\u7ec6\u80de<\/strong>\u6297\u80bf\u7624\u6d3b\u6027\u4f5c\u7528\u7684\u9003\u9038\u673a\u5236\u3002\u4e8b\u5b9e\u4e0a\uff0c\u80bf\u7624\u8fdb\u5c55\u901a\u5e38\u4e0e\u514d\u75ab\u7f16\u8f91\u8fc7\u7a0b\u6709\u5173\uff0c\u4f1a\u51fa\u73b0\u5bf9NK\u7ec6\u80de\u6d3b\u6027\u6709\u62b5\u6297\u529b\u7684\u6076\u6027\u514b\u9686\u3002\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4ece\u764c\u524d\u9636\u6bb5\u5230\u6076\u6027\u9636\u6bb5\u7684\u8f6c\u53d8\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684MICA<\/strong>\u8131\u843d\u6709\u5173\u3002\u8be5\u8131\u843d\u8fc7\u7a0b\u9664\u4e86\u964d\u4f4e\u80bf\u7624\u7ec6\u80de\u4e0aNKG2D\u914d\u4f53\u7684\u8868\u9762\u5bc6\u5ea6\u5916\uff0c\u8fd8\u4f1a\u4ea7\u751f\u53ef\u6eb6\u6027\u914d\u4f53<\/strong>\uff0c\u4e0b\u8c03\u514d\u75ab\u7ec6\u80de\u4e0aNKG2D\u7684\u8868\u8fbe<\/strong>\uff0c\u8fdb\u800c\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u9003\u9038<\/strong>\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u957f\u671f\u66b4\u9732\u4e8e\u8868\u9762\u7684\u4f4e\u4eb2\u548c\u529bNKG2D\u914d\u4f53<\/strong>\u4e5f\u4f1a\u5bfc\u81f4NK\u7ec6\u80de\u5bf9NKG2D\u4f9d\u8d56\u548c\u975e\u4f9d\u8d56\u9014\u5f84\u7684\u8131\u654f<\/strong>\u3002\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u9ad8\u4eb2\u548c\u529b\u7684NKG2D\u914d\u4f53\u548cMULT1\u7684\u8131\u843d\u5e76\u6ca1\u6709\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u7684\u8bc6\u522b\uff0c\u800c\u662f\u901a\u8fc7\u589e\u5f3aNK\u7ec6\u80de\u6548\u5e94\u5668\u529f\u80fd\u6765\u4fc3\u8fdb\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u3002\u8fd9\u63d0\u793aMULT1<\/strong>\u53ef\u963b\u6b62<\/strong>NK\u7ec6\u80de\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8868\u8fbe\u7684\u4f4e\u4eb2\u548c\u529b\u914d\u4f53(\u5982RAE-1)\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528<\/strong>\uff0c\u5e76\u6062\u590dNK\u7ec6\u80de\u7684\u53cd\u5e94\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

DNAM-1<\/strong>\u662f\u4e00\u79cd\u53ef\u4e0e\u6574\u5408\u7d20LFA-1\u7ed3\u5408\u4e14\u8868\u8fbe\u5728NK\u7ec6\u80de\u548cT\u7ec6\u80de\u4e0a\u7684\u9ecf\u9644\u5206\u5b50<\/strong>\uff0c\u5176\u53c2\u4e0e\u7ef4\u6301\u6eb6\u7ec6\u80de\u6027\u7a81\u89e6\u7684\u7a33\u5b9a\u3002\u6700\u521d\u53d1\u73b0DNAM-1\u5728\u7ec6\u80de\u95f4\u9ecf\u9644\u4e2d\u8d77\u4f5c\u7528\uff0c\u53ef\u8bc6\u522b\u4e00\u7c7b\u51dd\u96c6\u7d20\u548c\u51dd\u96c6\u7d20\u6837\u5206\u5b50\u5bb6\u65cf\u3002<\/p>\n

Nextin\u548cNextin\u6837\u5206\u5b50\u53c2\u4e0e\u4e86\u5e7f\u6cdb\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\uff0c\u5b83\u4eec\u663e\u8457\u8c03\u8282T\u7ec6\u80de\u3001NK\u7ec6\u80de\u548c\u6297\u539f\u63d0\u5448\u7ec6\u80de\u7684\u514d\u75ab\u529f\u80fd\u3002\u9664\u4e86\u589e\u5f3aNK\u7ec6\u80de\u9ecf\u9644\u548c\u7ec6\u80de\u6bd2\u4f5c\u7528<\/strong>\u5916\uff0cDNAM-1\u8fd8\u80fd\u4fc3\u8fdb\u5e72\u6270\u7d20-\u03b3\u7684\u5206\u6ccc<\/strong>\u3002<\/p>\n

\u6b64\u5916\uff0c\u53ef\u4ee5\u901a\u8fc7DNAM-1\u7684\u8868\u8fbe\u533a\u5206\u5c0f\u9f20\u4f53\u5185\u7684\u4e24\u4e2a\u529f\u80fdNK\u7ec6\u80de\u4e9a\u7fa4\u3002\u4e0eDNAM-1\u2212<\/sup>NK\u7ec6\u80de\u76f8\u6bd4\uff0cDNAM-1+<\/sup>NK\u7ec6\u80de\u80fd\u589e\u5f3aIL-15\u4fe1\u53f7<\/strong>\uff0c\u4ea7\u751f\u66f4\u9ad8\u6c34\u5e73\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0cDNAM-1<\/strong>\u5728\u5c0f\u9f20\u809d\u810fILC1<\/strong>\u4e0a\u9ad8\u6c34\u5e73\u8868\u8fbe\uff0c\u5728\u65e9\u671fILC\u524d\u4f53\u548c\u5c0f\u9f20\u9aa8\u9ad3\u4e2dILC2\u524d\u4f53\u4e0a\u4e5f\u80fd\u68c0\u6d4b\u5230DNAM-1\u3002\u7136\u800c\uff0cDNAM-1\u8c03\u8282\u8f85\u52a9\u578bILC\u529f\u80fd\u7684\u4f5c\u7528\u4ecd\u6709\u5f85\u7814\u7a76\u3002<\/p>\n

DNAM-1\u914d\u4f53CD155<\/strong>(\u4e5f\u79f0\u4e3aPVR)\u548cCD112(\u4e5f\u79f0\u4e3aNectin-2\u3001PRR2\u6216PVRL2)\u901a\u5e38\u5728\u5b9e\u4f53\u80bf\u7624\u548c\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624<\/strong>\u4e2d\u8fc7\u5ea6\u8868\u8fbe\u3002\u4e0e\u4e0a\u8ff0\u4ecb\u7ecd\u8fc7\u7684NKG2D\u914d\u4f53\u7c7b\u4f3c\uff0c\u80bf\u7624\u7ec6\u80de\u8868\u8fbeDNAM-1\u914d\u4f53CD155\u4f3c\u4e4e\u662f\u7531\u4e8e\u590d\u5236\u538b\u529b\u5bfc\u81f4\u7684DNA\u635f\u4f24\uff0c\u8fd9\u4e00\u9014\u5f84\u4f9d\u8d56\u4e00\u79cd\u68c0\u6d4b\u53cc\u94feDNA\u65ad\u88c2\u7684\u9176ATM\u3002<\/p>\n

\u5728E\u03bc-Myc\u5c0f\u9f20\u6dcb\u5df4\u7624\u6a21\u578b\u4e2d\u8fdb\u884c\u7684\u4e00\u9879\u6709\u8da3\u7684\u7814\u7a76\u8bc1\u5b9e\uff0cDNA\u635f\u4f24\u53cd\u5e94\u8bf1\u5bfc\u65e9\u671f\u8f6c\u5316\u7684B\u7ec6\u80de\u4e0aCD155\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u5bfc\u81f4\u90e8\u5206\u4f9d\u8d56\u4e8eDNAM-1\u7684\u81ea\u53d1\u80bf\u7624\u6d88\u9000\u3002<\/p>\n

DNAM-1<\/strong>\u5728\u514d\u75ab\u76d1\u6d4b\u4e2d\u7684\u4f5c\u7528\u5728\u4e8e\u53ef\u4ee5\u8bf1\u5bfc\u7ea4\u7ef4\u8089\u7624<\/strong>\u7684\u53d1\u5c55\uff0c\u4ee5\u53ca\u4fc3\u8fdbDNAM-1\u7f3a\u9677\u5c0f\u9f20\u81ea\u53d1\u548c\u53ef\u79fb\u690d\u80bf\u7624<\/strong>\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NK\u7ec6\u80de\u8868\u8fbe\u7684\u6fc0\u6d3b\u53d7\u4f53<\/strong>\u548c\u6291\u5236\u53d7\u4f53<\/strong>\u79cd\u7c7b\u7e41\u591a\uff0c\u6291\u5236\u53d7\u4f53\u53ef\u4ee5\u9632\u6b62NK\u7ec6\u80de\u6740\u6b7b\u6b63\u5e38\u7684\u7ec4\u7ec7\u548c\u6291\u5236NK\u7ec6\u80de\u5bf9\u4e0b\u8c03MHC-I\u7c7b\u5206\u5b50(MHC-I)\u7684\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\uff08\u6291\u5236\u4e86\u201c\u4e22\u5931\u81ea\u6211\u8bc6\u522b\u201d)\u3002<\/p>\n

\u4eba\u7c7bKIR\u5bb6\u65cf\u7684NK\u7ec6\u80de\u53d7\u4f53\u548c\u5c0f\u9f20Ly49\u5bb6\u65cf\u7684NK\u7ec6\u80de\u53d7\u4f53\u53ef\u76f4\u63a5\u8bc6\u522bMHC-Ia<\/strong>\u5206\u5b50\u3002\u6b64\u5916\uff0c\u4eba\u7c7b\u548c\u9f20\u90fd\u53ef\u8868\u8fbeCD94\/NKG2A\u5f02\u4e8c\u805a\u4f53\u53d7\u4f53\uff0cCD94\/NKG2A<\/strong>\u5f02\u4e8c\u805a\u4f53\u4e0e\u4eba\u7684\u975e\u5178\u578bMHC\u5206\u5b50HLA-E\u548c\u5c0f\u9f20\u7684Qa-1\u9012\u5448\u7684\u80bd\u7ed3\u5408\u3002<\/p>\n

\u8fd9\u4e9b\u53d7\u4f53\u4e0eMHC-I\u6210\u529f\u7ed3\u5408\u540e\u4f1a\u4f20\u9012\u4e00\u79cd\u6291\u5236\u4fe1\u53f7<\/strong>\uff0c\u4ece\u800c\u6270\u4e71NK\u7ec6\u80de\u7684\u6fc0\u6d3b\u9014\u5f84<\/strong>\u3002\u4f8b\u5982\uff0c\u6291\u5236\u6027\u53d7\u4f53KIR2DL2<\/strong>\u53c2\u4e0e\u963b\u6b62\u6fc0\u6d3b\u53d7\u4f53\u805a\u96c6\u548c\u8bf1\u5bfc\u808c\u52a8\u86cb\u767d\u91cd\u5851\uff0c\u540c\u65f6\u53c2\u4e0e\u9776\u7ec6\u80de\u56de\u7f29\u3002<\/p>\n

\u5728\u5173\u4e8e\u5c0f\u9f20\u8089\u7624\u4e2dLY49\u6291\u5236\u53d7\u4f53<\/strong>\u6c34\u5e73\u964d\u4f4e\u548c\u81ea\u53d1\u6027B\u7ec6\u80de\u6dcb\u5df4\u7624\u53d1\u75c5\u52a0\u901f\u7684\u76f8\u5173\u62a5\u9053\u4e2d\uff0c\u4f53\u73b0\u4e86\u201c\u4e22\u5931\u81ea\u6211\u201d\u8bc6\u522b\u5728NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u76d1\u63a7\u4e2d\u7684\u91cd\u8981\u6027\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0cNK\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u201c\u4e22\u5931\u81ea\u6211\u201d\u8bc6\u522b\u4e2d\u552f\u4e00\u7684ILC\u4e9a\u7fa4\u4ecb\u4f53\u3002\u867d\u7136\u5728\u5176\u4ed6ILC\u4e9a\u7fa4\u7684\u8868\u9762\u5df2\u7ecf\u68c0\u6d4b\u5230Ly49\u53d7\u4f53\uff0c\u4f46\u662f\u5b83\u4eec\u7684\u529f\u80fd\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u5176\u4ed6\u53d7\u4f53\u4e5f\u53ef\u80fd\u53c2\u4e0e\u8c03\u8282ILC\u529f\u80fd\u3002\u514d\u75ab\u68c0\u67e5\u70b9\u5206\u5b50CTLA-4<\/strong>\u548cPD-1<\/strong>\u53ef\u4ee5\u6291\u5236NK\u7ec6\u80de\u7684\u6d3b\u6027<\/strong>\u5e76\u6784\u6210\u91cd\u8981\u7684\u4e34\u5e8a\u9776\u70b9\uff0c\u4f46\u5bf9\u4e8e\u5b83\u4eec\u5728\u764c\u75c7\u56fa\u6709\u514d\u75ab\u68c0\u6d4b\u4e2d\u7684\u4f5c\u7528\u4ecd\u77e5\u4e4b\u751a\u5c11\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5c0f\u9f20\u7684\u8f85\u52a9\u578bILC\u524d\u4f53\u7684\u7279\u5f81\u662f\u9ad8\u8868\u8fbe\u7684PD-1\u3002\u6b64\u5916\uff0c\u5f88\u5c11\u6709\u6210\u719f\u7684ILC\u8868\u8fbePD-1\uff0c\u4f46\u5b83\u4eec\u5728\u6fc0\u6d3b\u65f6\u4f1a\u4e0a\u8c03PD-1\uff0c\u56e0\u6b64\u4ecd\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u6765\u8bc4\u4f30PD-1\u5728\u80bf\u7624\u5185ILC\u4e0a\u7684\u4f5c\u7528<\/strong>\u3002<\/p>\n

TIGIT<\/strong>\u548cCD96<\/strong>\u4e0eNextin\u548cNectin\u6837\u5206\u5b50\u5bb6\u65cf\u76f8\u4e92\u4f5c\u7528\u7684\u53d7\u4f53\u80fd\u6709\u6548\u6291\u5236NK\u7ec6\u80de\u548cT\u7ec6\u80de\u529f\u80fd\uff0c\u5b83\u4eec\u53ef\u4ee5\u4e0eCD155<\/strong>\u7ed3\u5408\u5e76\u62b5\u6d88DNAM-1\u4ecb\u5bfc\u7684NK\u7ec6\u80de\u6d3b\u5316\u3002TIGIT\u53ef\u6291\u5236\u5c0f\u9f20\u548c\u4ebaNK\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff0cCD96\u53ef\u51cf\u5c11\u5c0f\u9f20NK\u7ec6\u80de\u4ea7\u751f\u5e72\u6270\u7d20-\u03b3\u3002CD96\u57fa\u56e0\u7f3a\u9677\u7684\u5c0f\u9f20\u5bf9\u5b9e\u9a8c\u6027\u80ba\u8f6c\u79fb\u548c\u764c\u53d8\u8868\u73b0\u51fa\u5f88\u5f3a\u7684\u62b5\u6297\u529b\uff0c\u800cTIGIT\u5728NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u764c\u75c7\u76d1\u6d4b\u4e2d\u7684\u4f5c\u7528\u4ecd\u6709\u5f85\u7814\u7a76\u8bc1\u660e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/section>\n
for Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | <\/span><\/span>Camille Guillerey and Mark J. Smyth<\/span><\/span><\/section>\n
\u7ffb\u8bd1 | \u90d1\u68a6\u6021 \u7f57\u4f73\u4f73 \u5f90\u66fc\u65af<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u8d75\u6db5<\/span><\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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