{"id":2603,"date":"2022-06-03T10:21:13","date_gmt":"2022-06-03T02:21:13","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2022\/06\/03\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac9%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%9d%80%e4%bc%a4%e7%bb%86%e8%83%9e%e4%bb%a5%e5%8f%8a%e5%85%b6%e5%ae%83%e5%9b%ba%e6%9c%89%e6%b7%8b-2\/"},"modified":"2022-06-03T10:21:13","modified_gmt":"2022-06-03T02:21:13","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac9%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%9d%80%e4%bc%a4%e7%bb%86%e8%83%9e%e4%bb%a5%e5%8f%8a%e5%85%b6%e5%ae%83%e5%9b%ba%e6%9c%89%e6%b7%8b-2","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2022\/06\/03\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac9%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%9d%80%e4%bc%a4%e7%bb%86%e8%83%9e%e4%bb%a5%e5%8f%8a%e5%85%b6%e5%ae%83%e5%9b%ba%e6%9c%89%e6%b7%8b-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c9\u7ae0\uff1a\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4ee5\u53ca\u5176\u5b83\u56fa\u6709\u6dcb\u5df4\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u76d1\u89c6\u4f5c\u7528\uff08\u4e0b)"},"content":{"rendered":"
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DRAGON BOAT<\/strong><\/p>\n

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DRAGON BOAT<\/p>\n

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 2021\/06\/14 <\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u795d\u5927\u5bb6\u7aef\u5348\u5b89\u5eb7\uff01<\/span><\/strong><\/p>\n

\u4e0a\u671f\u5185\u5bb9\u94fe\u63a5\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c9\u7ae0\uff1a\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4ee5\u53ca\u5176\u5b83\u56fa\u6709\u6dcb\u5df4\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u76d1\u89c6\u4f5c\u7528\uff08\u4e0a)<\/span>
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\uff0c\u4eca\u5929\u6211\u4eec\u7ee7\u7eed\u5b66\u4e60\u540e\u9762\u7684\u5185\u5bb9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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9.3 \u6fc0\u6d3bILC\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u53ef\u6eb6\u6027\u56e0\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5916\uff0cILC\uff08\u5148\u5929\u6dcb\u5df4\u7ec6\u80de\uff09<\/strong>\u8fd8\u6574\u5408\u4e86\u7531\u53ef\u6eb6\u6027\u4ecb\u8d28\u63d0\u4f9b\u7684\u591a\u79cd\u4fe1\u53f7\uff0c\u5982\u4e0a\u76ae\u7ec6\u80de\u3001\u95f4\u8d28\u7ec6\u80de\u6216\u9ad3\u6837\u7ec6\u80de\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50\u3001\u8b66\u62a5\u7d20\u3001\u8102\u8d28\u6216\u7531\u4e0a\u76ae\u7ec6\u80de\u3001\u57fa\u8d28\u7ec6\u80de\u6216\u9aa8\u9ad3\u7ec6\u80de\u4ea7\u751f\u7684\u6fc0\u7d20 (Fig 9.3<\/span>)\u3002<\/p>\n

\u80bf\u7624\u7684\u751f\u957f\u53ef\u80fd\u4f1a\u6270\u4e71\u5468\u56f4\u7ec4\u7ec7\u7684\u52a8\u6001\u5e73\u8861\uff0c\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50\u548c\u5371\u9669\u4fe1\u53f7\u7684\u91ca\u653e<\/strong>\uff0c\u8fd9\u53ef\u80fd\u4f1a\u9020\u6210ILC\u4ecb\u5bfc\u7684\u514d\u75ab\u76d1\u89c6<\/strong>\u3002NK\u7ec6\u80de<\/strong>\u548c\u8f85\u52a9\u6027ILC1<\/strong>\u5bf9IL-12\u3001IL-15\u548cIL-18\u5747\u6709\u53cd\u5e94\uff0c\u800cILC2<\/strong>\u4e3b\u8981\u5bf9IL-25\u3001IL-33\u548cTSLP\u6709\u53cd\u5e94\uff0cILC3<\/strong>\u5219\u7531IL-23\u548cIL-1\u03b2\u6fc0\u6d3b\u3002<\/p>\n

\u51e0\u4e4e\u6ca1\u6709\u76f4\u63a5\u8bc1\u636e\u53ef\u4ee5\u8bc1\u660e\u751f\u7406\u5206\u6ccc\u7684\u7ec6\u80de\u56e0\u5b50\u5bf9\u764c\u75c7\u4e2dILC\u7684\u4f5c\u7528\uff0c\u5927\u591a\u6570\u7814\u7a76\u66f4\u591a\u7684\u662f\u5173\u6ce8\u5916\u6e90\u6027\u7ec6\u80de\u56e0\u5b50<\/strong>\u7684\u4f5c\u7528\uff0c\u6216\u8005\u4f7f\u7528\u57fa\u56e0\u64cd\u7eb5\u7684\u80bf\u7624\u6216\u5c0f\u9f20\u3002<\/p>\n

\u4f8b\u5982\uff0c\u4e00\u4efd\u62a5\u544a\u63cf\u8ff0\u4e86\u8fc7\u5ea6\u8868\u8fbeIL-15<\/strong>\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u5bf9\u76ae\u4e0b\u6ce8\u5c04\u7f3a\u4e4fMHC-I<\/strong>\u7684B16<\/strong>\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u5177\u6709\u62b5\u6297\u529b<\/strong>\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u5728\u6ca1\u6709CD4+<\/sup>\u6216CD8+<\/sup>T\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\uff0c\u5176\u6297\u80bf\u7624\u6d3b\u6027\u4fdd\u6301\u4e0d\u53d8\uff0c\u4f46\u5f53NK\u7ec6\u80de<\/strong>\u88ab\u6297asialo-GM1<\/strong>\u6297\u4f53\u8017\u5c3d\u65f6\uff0c\u5176\u4fdd\u62a4\u4f5c\u7528\u5c31\u4e27\u5931\u4e86\u3002<\/p>\n

\u6b64\u5916\uff0cIL-2\u3001IL-12\u548cIL-18<\/strong>\u80fd\u4fc3\u8fdbNK\u7ec6\u80de<\/strong>\u4ecb\u5bfc\u7684\u5c0f\u9f20\u5b9e\u9a8c\u6027\u8f6c\u79fb\u7684\u8c03\u63a7\uff0cIL-12\u3001IL-15\u548cIL-18<\/strong>\u9884\u6fc0\u6d3b\u7684NK\u7ec6\u80de\u663e\u793a\u6301\u7eed\u7684\u6548\u5e94\u529f\u80fd\uff0c\u5e76\u5ef6\u7f13MHC-I\u7f3a\u9677\u5c0f\u9f20\u80bf\u7624\u7684\u751f\u957f\u3002\u6709\u8da3\u7684\u662f\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8bc1\u5b9e\uff0cIL-12<\/strong>\u8bf1\u5bfc\u7684\u5bf9\u76ae\u4e0bB16\u9ed1\u8272\u7d20\u7624\u7684\u6291\u5236\u662f\u7531NKp46+<\/sup>NK1.1\u2212<\/sup>ILC3<\/strong>\u7fa4\u4f53\u4ecb\u5bfc\u7684\uff0c\u8be5\u7ec6\u80de\u7fa4\u7684\u5206\u5316\u53d7\u8f6c\u5f55\u56e0\u5b50ROR\u03b3t<\/strong>\u8c03\u63a7\u3002<\/p>\n

\u6700\u540e\uff0cNK\u7ec6\u80de\u548cILC3s\u8868\u8fbe\u7684Toll\u6837\u53d7\u4f53<\/strong>\u53ef\u80fd\u4f7f\u8fd9\u4e9b\u7ec6\u80de\u80fd\u591f\u68c0\u6d4b\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5b58\u5728\u7684\u5371\u9669\u76f8\u5173\u5206\u5b50\u6a21\u5f0f(DAMP)<\/strong>\u3002DAMP\u53ef\u76f4\u63a5\u6216\u95f4\u63a5\u901a\u8fc7\u523a\u6fc0\u8f85\u52a9\u7ec6\u80de\u8bf1\u5bfcNK\u7ec6\u80de\u6fc0\u6d3b<\/strong>\u3002\u6709\u8da3\u7684\u662f\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8bc1\u5b9e\uff0cTLR3\u7f3a\u9677<\/strong>\u5c0f\u9f20\u7684NK\u7ec6\u80de\u5bf9\u7ec6\u80de\u56e0\u5b50\u523a\u6fc0\u53cd\u5e94\u8fdf\u949d<\/strong>\uff0c\u8fd9\u4e00\u7f3a\u9677\u4e0e\u8fd9\u4e9b\u5c0f\u9f20\u5728\u53d7\u5230B16F10\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u653b\u51fb\u65f6\u589e\u52a0\u5b9e\u9a8c\u6027\u80ba\u8f6c\u79fb<\/strong>\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 9.3 <\/span>\u7ec6\u80de\u56e0\u5b50\u548c\u819c\u7ed3\u5408\u914d\u4f53\u53c2\u4e0eILC\u7684\u6d3b\u5316\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u7684IL-12\u3001IL-15\u548cIL-18\u7b49\u7ec6\u80de\u56e0\u5b50\u5728\u6fc0\u6d3b\u53d7\u4f53\u7684\u4f5c\u7528\u4e0b\u589e\u52a0\u4e86\u5b83\u4eec\u7684\u80fd\u529b\u3002IL-12\u548cIL-18\u4e5f\u53ef\u523a\u6fc0ILC1\u4ea7\u751f\u5e72\u6270\u7d20-\u03b3\u3002ILC2\u5bf9IL-25\u3001IL-33\u548cTSLP\u6709\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u4eba\u7c7bILC2\u5728NKp30\u53c2\u4e0e\u65f6\u88ab\u6fc0\u6d3b\uff0c\u800c\u4eba\u7c7bILC3\u5bf9NKp44\u523a\u6fc0\u6709\u53cd\u5e94\uff0cILC3\u88ab\u7ec6\u80de\u56e0\u5b50IL-1\u03b2\u548cIL-23\u6fc0\u6d3b\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8f85\u52a9\u6027ILC<\/strong>\u4e3b\u8981\u901a\u8fc7\u53ef\u6eb6\u6027\u4ecb\u8d28<\/strong>\u6fc0\u6d3b\uff0c\u800cNK\u7ec6\u80de\u53d7\u4f53<\/strong>\u662fNK\u7ec6\u80de\u6fc0\u6d3b\u7684\u4e3b\u8981\u9014\u5f84\u3002\u7136\u800c\uff0c\u76f8\u6bd4\u4e8e\u9759\u6b62\u7684NK\u7ec6\u80de\uff0c\u7ec6\u80de\u56e0\u5b50<\/strong>\u6fc0\u6d3b\u7684NK\u7ec6\u80de\u5bf9NK\u7ec6\u80de\u53d7\u4f53\u4fe1\u53f7\u66f4\u654f\u611f\u3002<\/p>\n

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9.4 ILC\u5bf9\u764c\u7ec6\u80de\u7684\u76f4\u63a5\u6e05\u9664\u4f5c\u7528<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u542b\u6709\u7a7f\u5b54\u7d20<\/strong>\u548c\u9897\u7c92\u9176<\/strong>\u7684\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u7684\u91ca\u653e\u6784\u6210\u4e86NK<\/strong>\u7ec6\u80de\u53d1\u6325\u6740\u4f24\u6d3b\u6027<\/strong>\u7684\u4e3b\u8981\u9014\u5f84\u3002\u7a7f\u5b54\u7d20<\/strong>\u662f\u4e00\u79cd\u6210\u5b54\u86cb\u767d\uff0c\u5b83\u5141\u8bb8\u9897\u7c92\u9176\u8fdb\u5165\u9776\u7ec6\u80de\uff0c\u4ece\u800c\u5f15\u53d1\u7ec6\u80de\u51cb\u4ea1\u3002\u7a7f\u5b54\u7d20\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7\u81ea\u53d1\u6027\u6dcb\u5df4\u7624\u7684\u4fb5\u88ad\uff0c\u5728\u5c0f\u9f20\u4e2d\u7684\u7814\u7a76\u8bc1\u5b9e\u4e86\u7a7f\u5b54\u7d20<\/strong>\u5728NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u7f3a\u4e4fMHC-I<\/strong>\u7684\u80bf\u7624\u6392\u65a5<\/strong>\u53cd\u5e94\u4e2d\u7684\u4e3b\u8981\u4f5c\u7528\uff0c\u4ee5\u53caNK\u7ec6\u80de\u4ecb\u5bfc\u7684\u8f6c\u79fb\u63a7\u5236<\/strong>\u548c\u5bf9\u81f4\u764c\u7269\u8bf1\u5bfc\u7684\u7ea4\u7ef4\u8089\u7624\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u9897\u7c92\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027<\/strong>\u6700\u521d\u88ab\u8ba4\u4e3a\u662fNK<\/strong>\u7ec6\u80de\u533a\u522b\u4e8eILC1\u7ec6\u80de\u7684\u7279\u5f81\u3002<\/p>\n

\u7136\u800c\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u4e00\u7fa4\u660e\u663e\u4e0d\u540c\u4e8e\u4f20\u7edfNK\u7ec6\u80de\u7684ILC1<\/strong>\u6837\u7ec6\u80de\u4e5f\u80fd\u4ee5\u7a7f\u5b54\u7d20<\/strong>\u4f9d\u8d56\u7684\u65b9\u5f0f\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u9879\u7814\u7a76\u4f7f\u7528\u81ea\u53d1\u6027\u5c0f\u9f20\u4e73\u817a\u764c\u6a21\u578b\u8868\u660e ILC1 \u6837\u7ec6\u80de\u800c\u975e\u5e38\u89c4 NK \u7ec6\u80de\u6709\u52a9\u4e8e\u51cf\u5c11\u80bf\u7624\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fas\u914d\u4f53<\/strong>(FasL\u6216CD95L)\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50<\/strong>\u76f8\u5173\u7684\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53(TRAIL)\u5c5e\u4e8e\u6b7b\u4ea1\u53d7\u4f53\u9014\u5f84\uff0c\u4ee3\u8868\u4e86NK<\/strong>\u7ec6\u80de\u6e05\u9664\u9776\u7ec6\u80de\u7684\u53e6\u4e00\u79cd\u673a\u5236\u3002<\/p>\n

FasL\u6216TRAIL<\/strong>\u4e0e\u5176\u53d7\u4f53(\u5206\u522b\u4e3aFas\u548cDR5\u6216DR4<\/strong>)\u7684\u7ed3\u5408\u53ef\u89e6\u53d1\u5e38\u89c1\u7684\u6b7b\u4ea1\u4fe1\u53f7<\/strong>\u5206\u5b50FADD\u3001caspase8\u548ccaspase3\u7684\u6fc0\u6d3b\uff0c\u5e76\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1<\/strong>\u3002\u4ee5Fas\u548cTRAIL\u6b7b\u4ea1\u53d7\u4f53\u901a\u8def\u4e3a\u9776\u70b9\uff0c\u7ed5\u8fc7\u764c\u75c7\u5e72\u7ec6\u80de\u7684\u96be\u6cbb\u6027\uff0c\u4ece\u800c\u8fdb\u884c\u5e38\u89c4\u6cbb\u7597\u7684\u76f8\u5173\u6027\u5df2\u7ecf\u5728\u5c0f\u9f20\u8eab\u4e0a\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n

\u6700\u521d\uff0cTRAIL<\/strong>\u9633\u6027\u7684NK\u7ec6\u80de\u5728\u5e7c\u7a1a\u5c0f\u9f20\u7684\u809d\u810f\u4e2d\u88ab\u53d1\u73b0\uff1b\u5728\u4f53\u5916\uff0c\u809d\u810f<\/strong>\u7684NK\u7ec6\u80de\u7684\u6740\u4f24\u6d3b\u6027\u88ab\u8bc1\u660e\u662f\u4f9d\u8d56TRAIL\u7684\u3002\u56e0\u6b64\uff0cTRAIL\u4f3c\u4e4e\u5bf9\u63a7\u5236\u5c0f\u9f20\u5b9e\u9a8c\u6027\u809d\u8f6c\u79fb\u662f\u5fc5\u8981\u7684\u3002\u6709\u8da3\u7684\u662f\uff0cTRAIL\u5728\u65b0\u751f\u5c0f\u9f20<\/strong>\u4f53\u5185\u4e3b\u8981\u7531\u672a\u6210\u719f\u7684NK\u7ec6\u80de\u8868\u8fbe\uff0c\u662f\u80ce\u513fNK\u7ec6\u80de\u4f53\u5916\u6740\u4f24TRAIL\u654f\u611f\u9776\u70b9\u6240\u5fc5\u9700\u7684\u3002\u540c\u6837\uff0cTRAIL\u662f\u4eba\u8110\u8840NK\u7ec6\u80de<\/strong>\u4f53\u5916\u6740\u4f24\u6d3b\u6027\u6240\u5fc5\u9700\u7684\uff0c\u800c\u6210\u719f\u7684\u4ebaNK\u7ec6\u80de<\/strong>\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\u4e3b\u8981\u4f9d\u8d56\u4e8e\u7a7f\u5b54\u7d20<\/strong>\u548cFasL\u9014\u5f84<\/strong>\u3002<\/p>\n

\u867d\u7136TRAIL+<\/sup>\u80ce\u513fNK<\/strong>\u7ec6\u80de\u7684\u6765\u6e90\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u5c0f\u9f20\u809d\u810fTRAIL+<\/sup>NKp46+<\/sup><\/strong>\u7ec6\u80de\u73b0\u5df2\u88ab\u5f52\u5165ILC1<\/strong>\u8c31\u7cfb\u3002\u5728\u5065\u5eb7\u4eba\u7684\u809d\u810f\u4e2d\uff0cNK\u7ec6\u80de\u4e0d\u8868\u8fbeTRAIL\uff0c\u4f46\u5176\u8868\u8fbe\u53ef\u88ab\u4fc3\u708e<\/strong>\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u3002\u6700\u8fd1\u7814\u7a76\u8868\u660e\uff0cTRAIL\u7684\u4e0a\u8c03\u4ec5\u9650\u4e8e\u8868\u8fbeCXCR6<\/strong>\u7684\u7279\u5b9a\u4eba\u7fa4\u7684\u4eba\u809d\u5185NK\u7ec6\u80de\uff0c\u800c\u5916\u5468\u7f3a\u4e4f\u3002\u56e0\u6b64\uff0c\u5728\u6ca1\u6709\u708e\u75c7\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\uff0cTRAIL\u7684\u8868\u8fbe\u53ef\u80fd\u4ec5\u9650\u4e8eI\u578bILC<\/strong>\u7684\u7ec4\u7ec7\u9a7b\u7559\u4e9a\u7fa4\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u5728\u5c0f\u9f20\u7684\u553e\u6db2\u817aILC1<\/strong>\u548c\u80bf\u7624\u6d78\u6da6\u6027ILC1<\/strong>\u6837\u7ec6\u80de<\/strong>\u4e0a\u4e5f\u68c0\u6d4b\u5230TRAIL\u3002\u7136\u800c\uff0c\u6211\u4eec\u8fd8\u89c2\u5bdf\u5230\u7ec6\u80de\u56e0\u5b50\u523a\u6fc0\u8bf1\u5bfc\u5c0f\u9f20\u813e\u810f\u4e2d\u7684CD3-NK1.1+<\/sup>\u7ec6\u80de<\/strong>\u548c\u4eba\u8840\u6db2\u4e2d\u7684CD3–<\/sup>CD56+<\/sup>\u7ec6\u80de<\/strong>\u4e0a\u7684TRAIL<\/strong>\u8868\u8fbe\uff0c\u8fd9\u8868\u660eTRAIL\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u4e5f\u6709\u52a9\u4e8e\u5e38\u89c4NK\u7ec6\u80de\u7684\u529f\u80fd\u3002\u4e8b\u5b9e\u4e0a\uff0c\u819c\u7ed3\u5408\u7684TRAIL\u8865\u5145<\/strong>\u4e86\u7a7f\u5b54\u7d20<\/strong>\u4ecb\u5bfc\u7684\u4ece\u4eba\u5916\u5468\u8840\u4e2d\u5206\u79bb\u7684\u6d3b\u5316NK\u7ec6\u80de\u5bf9\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\u7cfb\u7684\u6740\u4f24\u4f5c\u7528<\/strong>\u3002<\/p>\n

\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u5e94\u8be5\u4f1a\u9610\u660e\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u5e38\u89c4NK<\/strong>\u7ec6\u80de\u548c\u7ec4\u7ec7\u9a7b\u7559\u7684ILC1<\/strong>\u5728TRAIL\u4ecb\u5bfc\u7684\u65b0\u751f\u80bf\u7624\u63a7\u5236\u4e2d\u5404\u81ea\u626e\u6f14\u7684\u89d2\u8272\u3002\u4e0eTRAIL\u7684\u7814\u7a76\u76f8\u53cd\uff0c\u652f\u6301FasL\u5728NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u4f53\u5185\u80bf\u7624\u63a7\u5236\u4e2d\u7684\u4f5c\u7528\u7684\u6570\u636e\u975e\u5e38\u6709\u9650\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u8bc1\u660e\uff0cIL-18<\/strong>\u8bf1\u5bfc\u5c0f\u9f20NK\u7ec6\u80de\u8868\u9762FasL<\/strong>\u7684\u5feb\u901f\u8868\u8fbe\uff0c\u5e76\u53d1\u73b0NK\u7ec6\u80de\u4ecb\u5bfc\u7684FasL\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\u53ef\u4ee5\u63a7\u5236MC38\u5c0f\u9f20\u7684\u809d\u8f6c\u79fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

I\u578bILCs<\/strong>\u7684\u4e00\u4e2a\u91cd\u8981\u7279\u5f81\u662f\u5206\u6ccc\u5e72\u6270\u7d20-\u03b3<\/strong>\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09<\/strong>\u3002\u8fd9\u4e24\u79cd\u7ec6\u80de\u56e0\u5b50\u5728\u80bf\u7624\u53d1\u751f\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\uff0c\u5b83\u4eec\u4e0d\u4ec5\u80fd\u8c03\u8282\u514d\u75ab\u53cd\u5e94<\/strong>\uff0c\u8fd8\u80fd\u76f4\u63a5\u5f71\u54cd\u80bf\u7624\u7ec6\u80de<\/strong>\u7684\u751f\u547d\u673a\u7406\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728\u53bb\u9664\u5e72\u6270\u7d20-\u03b3\u5bf9\u80bf\u7624\u7684\u53cd\u5e94\u6027\u540e\uff0c\u5df2\u7ecf\u89c2\u5bdf\u5230\u5404\u79cd\u5c0f\u9f20\u7ec6\u80de\u7cfb\u5728\u4f53\u5185\u7684\u589e\u6b96\u52a0\u5f3a\u3002<\/p>\n

\u5bf9\u5e72\u6270\u7d20-\u03b3<\/strong>\u7684\u5e94\u7b54\u662f\u7531JAK-STAT<\/strong>\u4fe1\u53f7\u901a\u8def\u8bf1\u5bfc\u7684\u3002\u5728\u764c\u7ec6\u80de\u4e2d\uff0c\u8fd9\u4e00\u9014\u5f84\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u6291\u5236\u7ec6\u80de\u589e\u6b96<\/strong>\u548c\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1<\/strong>\u3002Schreiber\u548c\u4ed6\u7684\u540c\u4e8b\u5df2\u7ecf\u8bc1\u660e\u4e86\u5185\u6e90\u6027\u5e72\u6270\u7d20-\u03b3<\/strong>\u5728\u4fc3\u8fdb\u514d\u75ab\u4ecb\u5bfc\u7684\u6d88\u9664\u65b0\u751f\u80bf\u7624\u7ec6\u80de\u4e2d\u6240\u8d77\u7684\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n

\u65e9\u671f\u7814\u7a76\u8868\u660e\uff0c\u7a7f\u5b54\u7d20<\/strong>\u548c\u5e72\u6270\u7d20-\u03b3<\/strong>\u9014\u5f84\u7684\u7ed3\u5408\u53ef\u4ee5\u89e3\u91ca\u5c0f\u9f20NK\u7ec6\u80de\u7684\u6297\u8f6c\u79fb<\/strong>\u6d3b\u6027\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u7531\u4e8e\u5e72\u6270\u7d20-\u03b3\u53ef\u4ee5\u7531\u8bb8\u591a\u4e0d\u540c\u7684\u5929\u7136\u548c\u83b7\u5f97\u6027\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u4ea7\u751f\uff0c\u56e0\u6b64\u76ee\u524d\u8fd8\u7f3a\u4e4f\u6b63\u5f0f\u7684\u8bc1\u636e\u8bc1\u660eILC<\/strong>\u5728\u5e72\u6270\u7d20-\u03b3<\/strong>\u4ecb\u5bfc\u7684\u514d\u75ab\u76d1\u89c6<\/strong>\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n

\u81f3\u4e8e\u80bf\u7624\u574f\u6b7b\u56e0\u5b50<\/strong>\uff0c\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u5728\u764c\u75c7\u751f\u7269\u5b66\u4e2d\u7684\u4f5c\u7528\u662f\u76f8\u5f53\u6a21\u7cca\u7684\u3002TNF\u7684\u4e24\u4e2a\u53d7\u4f53\u662fTNFR1\u548cTNFR2\uff0cTNFR1<\/strong>\u5728\u6240\u6709\u7c7b\u578b\u7684\u7ec6\u80de\u4e0a\u90fd\u6709\u8868\u8fbe\uff0c\u800cTNFR2<\/strong>\u4ec5\u9650\u4e8e\u514d\u75ab\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u8868\u8fbe\u3002<\/p>\n

\u4f46\u77db\u76fe\u7684\u662f\uff0cTNFR1<\/strong>\u65e2\u53ef\u4ee5\u4f20\u9012\u4fc3\u751f\u5b58<\/strong>\u4fe1\u53f7\uff0c\u4e5f\u53ef\u4ee5\u4f20\u9012\u4fc3\u51cb\u4ea1<\/strong>\u4fe1\u53f7\u3002\u56e0\u6b64\uff0c\u4e00\u4e9b\u62a5\u544a\u63cf\u8ff0\u4e86TNF\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u7ec6\u80de\u6291\u5236\u6216\u7ec6\u80de\u6bd2\u4f5c\u7528\uff0c\u800c\u53e6\u4e00\u4e9b\u62a5\u544a\u5219\u89c2\u5bdf\u5230\u4e86\u6076\u6027\u7ec6\u80de\u589e\u6b96\u7684\u589e\u5f3a\u3002\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u7f3a\u9677\u5c0f\u9f20\u7684NK1.1+<\/sup>\u813e\u7ec6\u80de\u5bf9YAC-1\u7684\u4f53\u5916\u6740\u4f24\u80fd\u529b\u964d\u4f4e\u7684\u73b0\u8c61\u8868\u660e\uff0c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53c2\u4e0e\u4e86NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u6740\u4f24\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u5bf9\u5316\u7597\u81f4\u654f\u7684\u5c0f\u9f20MC38\u80bf\u7624\u7684\u6740\u4f24\u4f5c\u7528\u88ab\u53d1\u73b0\u662f\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u4f9d\u8d56\u6027\u7684\u3002<\/p>\n

\u4f46\u603b\u4f53\u800c\u8a00\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u8fd8\u6ca1\u6709\u4ee4\u4eba\u4fe1\u670d\u7684\u8bc1\u636e\u8868\u660eTNF<\/strong>\u5bf9\u5929\u7136\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u6709\u91cd\u5927\u8d21\u732e\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6765\u81ea\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u7f3a\u9677\u5c0f\u9f20\u7684\u813e\u7ec6\u80de\u5728\u4f53\u5916\u5b8c\u5168\u80fd\u591f\u6eb6\u89e3MHC-I\u7f3a\u9677\u7684RMA-S\u80bf\u7624\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5728\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u7f3a\u4e4f\u7684\u5c0f\u9f20\u8fdb\u884c\u8179\u8154\u6ce8\u5c04\u540e\uff0c\u89c2\u5bdf\u5230RMA-S\u7ec6\u80de\u7684\u7f3a\u9677\u6d88\u9664\u3002\u8fd9\u4e00\u73b0\u8c61\u53ef\u4ee5\u7531\u5728\u7f3a\u4e4fTNF\u7684\u60c5\u51b5\u4e0b\u4f1a\u51cf\u5c11NK\u7ec6\u80de\u5728\u8179\u819c\u4e2d\u7684\u79ef\u805a\u6765\u89e3\u91ca\u3002<\/p>\n

\u6b64\u5916\uff0c\u5728\u6297CD319\u5355\u6297<\/strong>(Elotuzumab)\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0cTNF\u7684\u4e2d\u548c\u53ef\u6291\u5236NK\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u964d\u4f4e\u4ebaNK\u7ec6\u80de\u4ecb\u5bfc\u7684\u5bf9\u9aa8\u9ad3\u7624\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0cNK\u7ec6\u80de\u5206\u6ccc\u7684TNF\u867d\u7136\u6ca1\u6709\u76f4\u63a5\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff0c\u4f46\u53ef\u80fd\u5bf9\u80bf\u7624\u5fae\u73af\u5883<\/strong>\u8d77\u8c03\u8282\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u867d\u7136\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u76f4\u63a5\u7ec6\u80de\u6bd2\u6d3b\u6027\u88ab\u8ba4\u4e3a\u662fI\u578bILC\u7684\u7279\u5f02\u6027\uff0c\u4f46\u6700\u8fd1\u53d1\u73b0ILC2<\/strong>\u901a\u8fc7CXCR2<\/strong>\u9014\u5f84\u4e5f\u53ef\u76f4\u63a5\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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9.5 ILC\u4e0e\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528<\/span><\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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NK\u7ec6\u80de<\/strong>\u7684\u529f\u80fd\u8fdc\u8fdc\u4e0d\u6b62<\/strong>\u7b80\u5355\u5730\u6740\u6b7b\u764c\u7ec6\u80de<\/strong>\u3002\u9664\u4e86\u5e72\u6270\u7d20-\u03b3\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u5916\uff0c\u6fc0\u6d3b\u7684NK\u7ec6\u80de\u8fd8\u91ca\u653e\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\uff0c\u5305\u62ecGM-CSF\u3001IL-6\u548cIL-10<\/strong>\uff0c\u5b83\u4eec\u53ef\u80fd\u901a\u8fc7\u5206\u6ccc\u8d8b\u5316\u56e0\u5b50\u5982\u5355\u6838\u7ec6\u80de\u8d8b\u5316\u86cb\u767d-1(CCL2<\/strong>)\u3001\u5de8\u566c\u7ec6\u80de\u708e\u6027\u86cb\u767d-1\u03b1(CCL3<\/strong>)\u3001MIP-1\u03b2(CCL4<\/strong>)\u3001RANTES(CCL5<\/strong>)\u3001IL-8(CXCL8<\/strong>)\u548cIP-10(CXCL10<\/strong>)\u6765\u4fc3\u8fdb\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\u7684\u62db\u52df<\/strong>\u3002<\/p>\n

\u5df2\u663e\u793a NK<\/strong> \u7ec6\u80de\u4ea7\u751f\u7684 IFN-\u03b3 <\/strong>\u53ef\u4fc3\u8fdb\u5de8\u566c\u7ec6\u80de<\/strong>\u4ecb\u5bfc\u7684\u5c0f\u9f20\u81f4\u764c\u7269\u8bf1\u5bfc\u80bf\u7624\u7684\u514d\u75ab\u7f16\u8f91\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u4ee5\u8bb8\u591a\u4e0d\u540c\u7684\u65b9\u5f0f\u5f71\u54cdT\u7ec6\u80de<\/strong>\u53cd\u5e94\u7684\u7ed3\u679c\u3002\u4f8b\u5982\uff0cNK\u7ec6\u80de\u901a\u8fc7\u6e05\u9664<\/strong>\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de\uff08MDSC<\/strong>\uff09\u548c\u6fc0\u6d3bDC<\/strong>\u6765\u589e\u5f3a\u542f\u52a8\u7ec6\u80de\u6bd2\u6027CD8+<\/sup>T\u7ec6\u80de\u7684\u53cd\u5e94\u3002<\/p>\n

NK\u7ec6\u80de<\/strong>\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u548c\u968f\u540e\u6297\u539f\u7684\u91ca\u653e<\/strong>\u8fdb\u4e00\u6b65\u4fc3\u8fdb\u4e86T\u7ec6\u80de<\/strong>\u7684\u542f\u52a8\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u88ab\u62db\u52df\u5230\u53d1\u708e\u7684\u6dcb\u5df4\u7ed3<\/strong>\uff0c\u8fd9\u4e3a\u5e72\u6270\u7d20-\u03b3\u63d0\u4f9b\u4e86\u65e9\u671f\u6765\u6e90\uff0c\u662fCD4+<\/sup>T\u7ec6\u80deTh1\u578b\u6781\u5316<\/strong>\u6240\u5fc5\u9700\u7684\u3002\u6fc0\u6d3b\u7684\u8c03\u8282\u6027T\u7ec6\u80de(Tregs<\/strong>)\u7684\u76f4\u63a5\u7ec6\u80de\u6bd2\u6027\u662fNK\u7ec6\u80de\u589e\u5f3a\u6548\u5e94T\u7ec6\u80de\u53cd\u5e94\u7684\u53e6\u4e00\u79cd\u673a\u5236\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u4e00\u4e9b\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0cNK\u7ec6\u80de\u88ab\u53d1\u73b0\u6709\u52a9\u4e8e\u542f\u52a8\u80bf\u7624\u7279\u5f02\u6027\u8bb0\u5fc6T\u7ec6\u80de<\/strong>\uff0c\u8fd9\u662f\u957f\u671f\u63a7\u5236\u764c\u75c7\u6240\u9700\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6211\u4eec\u5bf9\u8f85\u52a9\u6027ILC<\/strong>\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u53cd\u5e94\u8c03\u8282\u7684\u7406\u89e3\u8fd8\u5904\u4e8e\u521d\u7ea7\u9636\u6bb5\u3002\u9274\u4e8e\u5e72\u6270\u7d20-\u03b3\u5728NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u8c03\u8282\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u5f88\u81ea\u7136\u5730\u8bbe\u60f3ILC1<\/strong>\u4ea7\u751f\u7684\u5e72\u6270\u7d20-\u03b3\u4e5f\u6709\u7c7b\u4f3c\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u7814\u7a76\u652f\u6301\u8fd9\u4e00\u8bf4\u6cd5\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u7531\u4e8e\u8fd9\u4e9b\u7ec6\u80de\u7684\u9ad8\u5ea6\u8868\u578b\u76f8\u4f3c\u6027\uff0cNK\u7ec6\u80de\u548cILC1\u7ec6\u80de\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u76f8\u5bf9\u8d21\u732e\u7684\u8bc4\u4f30\u53d8\u5f97\u590d\u6742\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cI\u578bILC<\/strong>\u7684TRAIL+<\/sup>\u6210\u5458\u4e5f\u53ef\u80fd\u6291\u5236T\u7ec6\u80de<\/strong>\u53cd\u5e94\u3002<\/p>\n

\u5173\u4e8eILC2s<\/strong>\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4ea7\u751f\u76842\u578b\u7ec6\u80de\u56e0\u5b50\u901a\u5e38\u6291\u5236<\/strong>1\u578b\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002\u7136\u800c\uff0c\u5728\u5b9e\u9a8c\u6027\u8f6c\u79fb\u7684\u5c0f\u9f20B16F10\u6a21\u578b\u4e2d\uff0c\u80baILC2s\u7ec6\u80de\u4ea7\u751f\u7684IL-5<\/strong>\u5df2\u88ab\u8bc1\u660e\u80fd\u4fc3\u8fdb\u55dc\u9178\u6027\u7c92\u7ec6\u80de<\/strong>\u7684\u52df\u96c6\u548c\u80ba\u90e8\u80bf\u7624\u7684\u6e05\u9664\u3002<\/p>\n

\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0cILC3s<\/strong>\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u5177\u6709\u79ef\u6781\u4f5c\u7528\uff0c\u5316\u7597\u4e0e\u80bf\u7624\u9776\u5411\u6297\u4f53\u8054\u5408\u6cbb\u7597\u53ef\u5ef6\u7f13B16\u76ae\u4e0b\u80bf\u7624\u7684\u751f\u957f\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u80bf\u7624\u6e05\u9664\u4f9d\u8d56\u4e8eCD90+<\/sup>NK1.1\u2212<\/sup>ROR\u03b3t+<\/sup><\/strong>\u5929\u7136\u6dcb\u5df4\u7ec6\u80de\uff0c\u5e76\u4e0e\u80bf\u7624\u7ec4\u7ec7\u5185\u5de8\u566c\u7ec6\u80de\u6d78\u6da6\u589e\u52a0\u6709\u5173\u3002<\/p>\n

\u53e6\u4e00\u4efd\u62a5\u544a\u663e\u793a\uff0cNKp46+<\/sup>ILC3<\/strong>\u80fd\u6291\u5236\u76ae\u4e0b\u6ce8\u5c04\u7684\u5206\u6cccIL-12\u7684B16F10\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u3002\u5728\u7f3a\u4e4fT\u7ec6\u80de\u6216\u5e38\u89c4NK\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\uff0c\u5206\u6cccIL-12<\/strong>\u7684\u80bf\u7624\u4ecd\u7136\u53d7\u5230\u6291\u5236\uff0c\u8868\u660eNKp46+<\/sup>ILC3s\u901a\u8fc7\u4e0a\u8c03\u80bf\u7624\u5185\u76ae\u7ec6\u80de\u8868\u9762\u9ecf\u9644\u5206\u5b50<\/strong>\u6765\u4ecb\u5bfc\u5176\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

\u7c7b\u4f3c\u5730\uff0c\u6709\u7814\u7a76\u53d1\u73b0\u4eba\u7c7b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC<\/strong>)\u7ec4\u7ec7\u4e2d\u5b58\u5728\u7684NCR+<\/sup>ILC3<\/strong>\u4ea7\u751f\u7684\u53ef\u6eb6\u6027\u56e0\u5b50\u53ef\u4ee5\u6fc0\u6d3b\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e2dILC3\u7684\u6570\u91cf<\/strong>\u4e0eTLS\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u6784(TLS<\/strong>)\u7684\u5bc6\u5ea6\u76f8\u5173\uff0cTLS\u662f\u4e00\u79cd\u5f02\u4f4d\u6dcb\u5df4\u5668\u5b98\uff0c\u4e0eNSCLC\u60a3\u8005\u7684\u826f\u597d\u9884\u540e\u76f8\u5173\u3002\u975e\u5e38\u6709\u8da3\u7684\u662f\uff0c\u665a\u671f\u80bf\u7624\u4e2d\u80bf\u7624\u6d78\u6da6NCR+<\/sup>ILC3s<\/strong>\u7684\u9891\u7387\u8f83\u4f4e\uff0c\u63d0\u793aNCR+<\/sup>ILC3s\u53ef\u80fd\u4e0eNSCLC\u60a3\u8005\u826f\u597d\u7684\u9884\u540e\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

\u603b\u7ed3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

ILC<\/strong>\u8d77\u7740\u54e8\u5175\u7684\u4f5c\u7528\uff0c\u4e00\u65e6\u5bbf\u4e3b\u4f53\u5185\u5e73\u8861\u53d7\u5230\u5e72\u6270\uff0c\u5c31\u4f1a\u8fc5\u901f\u505a\u51fa\u53cd\u5e94\u3002\u5b83\u4eec\u5feb\u901f\u800c\u6709\u529b<\/strong>\u7684\u53cd\u5e94\u53ef\u4ee5\u6682\u65f6\u63a7\u5236\u5371\u9669\uff0c\u5e76\u63d0\u9192\u5176\u4ed6\u514d\u75ab\u7ec6\u80de<\/strong>\u63d0\u4f9b\u957f\u671f\u4fdd\u62a4(Fig 9.4<\/span>)<\/span>\u3002<\/p>\n

\u957f\u671f\u4ee5\u6765\uff0cNK\u7ec6\u80de<\/strong>\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u6297\u764c\u75c7\u53d1\u5c55\u7684\u6700\u5f3a\u5927\u7684\u5148\u5929\u5b88\u62a4\u8005\u3002\u7136\u800c\uff0c\u6700\u8fd1ILC\u5bb6\u65cf<\/strong>\u7684\u6269\u5927\u53ef\u80fd\u4f1a\u5bf9\u8fd9\u4e00\u89c2\u70b9\u63d0\u51fa\u6311\u6218\uff0c\u5e76\u63d0\u51fa\u4e0d\u540cILC\u4e9a\u7fa4\uff0c\u7279\u522b\u662fNK\u7ec6\u80de\u548cILC1\u7684\u76f8\u5bf9\u8d21\u732e\u7684\u95ee\u9898\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5c3d\u7ba1NK\u7ec6\u80de<\/strong>\u4e0eILC1<\/strong>\u6709\u76f8\u5f53\u5927\u7684\u8f6c\u5f55\u91cd\u53e0\uff0c\u4f46NK\u7ec6\u80de\u80fd\u8868\u8fbe\u66f4\u9ad8\u7684\u8f6c\u5f55\u672c\uff0c\u7f16\u7801\u7ec6\u80de\u6bd2\u6027\u673a\u5236\u7684\u86cb\u767d\uff0c\u4ee5\u53ca\u53c2\u4e0e\u68c0\u6d4b\u8f6c\u5316\u7ec6\u80de\u7684\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u3002<\/p>\n

\u6b64\u5916\uff0c\u8f85\u52a9\u6027ILC<\/strong>\u662f\u9a7b\u7559\u5728\u7ec4\u7ec7\u4e2d\u7684\u7ec6\u80de\uff0c\u5b83\u53ea\u4f1a\u611f\u89c9\u5230\u5b83\u4eec\u6240\u5728\u7684\u7279\u5b9a\u5668\u5b98\u7684\u53d8\u5316\uff0c\u800c\u5e38\u89c4\u7684NK\u7ec6\u80de\u5728\u8840\u6db2\u4e2d\u5faa\u73af\uff0c\u53ef\u4ee5\u626b\u63cf\u5168\u8eab\u662f\u5426\u5b58\u5728\u53d7\u635f\u7ec6\u80de\u3002\u56e0\u6b64\uff0cNK\u7ec6\u80de\u53ef\u80fd\u662f\u6e05\u9664\u80bf\u7624\u7684\u6700\u6709\u6548\u7684ILC\u4e9a\u7fa4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 9.4 <\/span>\u56fa\u6709\u7684\u548c\u9002\u5e94\u6027\u7684\u6dcb\u5df4\u7ec6\u80de\u6709\u52a9\u4e8e\u764c\u75c7\u7684\u514d\u75ab\u76d1\u63a7\u3002\u5de6\u56fe\uff1aILC\u53ef\u76f4\u63a5\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u548c\/\u6216\u751f\u957f\u505c\u6ede\uff0c\u4e5f\u53ef\u523a\u6fc0\u5176\u4ed6\u56fa\u6709\u7ec6\u80de\u4ee5\u786e\u4fdd\u764c\u7ec6\u80de\u7684\u5feb\u901f\u6e05\u9664\u3002I\u578bILCs\u901a\u8fc7\u7ec6\u80de\u6bd2\u9897\u7c92\u9014\u5f84(\u7a7f\u5b54\u7d20\/\u9897\u7c92\u9176)\u6216\u6b7b\u4ea1\u914d\u4f53\u9014\u5f84(TRAIL)\u5bf9\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u76f4\u63a5\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4f20\u7edfNK\u7ec6\u80de\u548cILC1\u7ec6\u80de\u90fd\u6709\u8fd9\u79cd\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u4f46NK\u7ec6\u80de\u76ee\u524d\u88ab\u8ba4\u4e3a\u662f\u66f4\u6709\u6548\u7684\u6740\u624b\u3002I\u578bILC\u4ea7\u751f\u7684\u5e72\u6270\u7d20-\u03b3\u4e5f\u53ef\u76f4\u63a5\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5e76\u53ef\u80fd\u523a\u6fc0\u5de8\u566c\u7ec6\u80de\u7684\u6740\u7624\u6d3b\u6027\u3002ILC2\u53ef\u80fd\u901a\u8fc7\u5206\u6cccCXCL1\u548cCXCL2\u76f4\u63a5\u8bf1\u5bfc\u8868\u8fbeCXCR2\u7684\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002ILC2\u8fd8\u5206\u6cccIL-5\uff0c\u4ece\u800c\u62db\u52df\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u3002ILC3s\u53ef\u589e\u52a0\u5de8\u566c\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u6d78\u6da6\u3002\u53f3\u56fe\uff1aILC\u523a\u6fc0T\u7ec6\u80de\u53cd\u5e94\uff0c\u4ece\u800c\u786e\u4fdd\u5bf9\u764c\u7ec6\u80de\u7684\u957f\u671f\u4fdd\u62a4\u3002NK\u7ec6\u80de\u80fd\u6fc0\u6d3bDC\uff0c\u589e\u5f3a\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\uff0c\u8fd8\u80fd\u6740\u4f24\u514d\u75ab\u6291\u5236\u7ec6\u80de\uff0c\u5982\u6811\u7a81\u72b6\u7ec6\u80de(Tregs)\u548c\u9ad3\u7cfb\u6291\u5236\u7ec6\u80de(MDSC)\u3002ILC3\u6fc0\u6d3b\u57fa\u8d28\u548c\u5185\u76ae\u7ec6\u80de\uff0c\u4ece\u800c\u4fc3\u8fdb\u514d\u75ab\u7ec6\u80de\u5411\u80bf\u7624\u533a\u57df\u7684\u6d78\u6da6\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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ILC<\/strong>\u5728\u529f\u80fd\u6027\u9002\u5e94\u6027\u514d\u75ab\u4e2d\u7684\u91cd\u8981\u6027\u6700\u8fd1\u53d7\u5230\u8d28\u7591\uff0c\u56e0\u4e3a\u5728\u4e00\u7ec4SCID\u60a3\u8005\u4e2d\u53d1\u73b0\u5b58\u5728ILC\u7f3a\u9677\u4f3c\u4e4e\u6ca1\u6709\u4e25\u91cd\u7684\u4e34\u5e8a\u540e\u679c\u3002\u672c\u7814\u7a76\u5bf918\u4f8bIL2RG\u6216JAK3\u7a81\u53d8\u7684\u60a3\u8005\u8fdb\u884c\u4e867-39\u5e74\u7684\u968f\u8bbf\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u4e0d\u8fdb\u884c\u9aa8\u9ad3\u6e05\u9664\u672f\u7684\u60c5\u51b5\u4e0b\u63a5\u53d7\u4e86\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u3002\u7136\u800c\uff0c\u8fd9\u4e2a\u961f\u5217\u592a\u5c0f\uff0c\u4e0d\u80fd\u8bf4\u660eILC\u5728\u80bf\u7624\u514d\u75ab\u76d1\u6d4b\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u6837\u7684\u7814\u7a76\u4e5f\u53ef\u80fd\u9700\u8981\u66f4\u957f\u7684\u968f\u8bbf\u65f6\u95f4\u3002<\/p>\n

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\u76f8\u53cd\uff0cNSCLC\u7684\u4e00\u9879\u7814\u7a76\u8868\u660eNK\u7ec6\u80de<\/strong>\u6570\u91cf\u548c\u4e34\u5e8a\u7ed3\u679c\u4e4b\u95f4\u6ca1\u6709\u76f8\u5173\u6027\u3002\u5bf9\u665a\u671f\u764c\u75c7\u7f3a\u4e4fNK\u7ec6\u80de\u6d3b\u6027\u53ef\u80fd\u662f\u7531\u4e8e(1)\u80bf\u7624\u901a\u8fc7\u514d\u75ab\u7f16\u8f91\u8fc7\u7a0b\u9009\u62e9\u6297\u836f\u6027<\/strong>\u53d8\u5f02\u514b\u9686\u800c\u9003\u8131NK\u7ec6\u80de\u514d\u75ab\u76d1\u89c6\u548c\/\u6216(2)\u80bf\u7624\u5fae\u73af\u5883\u4e2dNK\u7ec6\u80de\u8017\u5c3d<\/strong>\uff0c\u5176\u4e2d\u591a\u79cd\u673a\u5236\u5bfc\u81f4NK\u7ec6\u80de\u529f\u80fd\u53d7\u963b\u3002<\/p>\n

\u817a\u82f7<\/strong>\u548c\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2<\/strong>\u662f\u4e24\u4e2a\u88ab\u8bc1\u5b9e\u5f71\u54cdNK\u7ec6\u80de\u6297\u80bf\u7624\u6d3b\u6027\u7684\u53ef\u6eb6\u6027\u56e0\u5b50\u3002\u6b64\u5916\uff0cNK\u7ec6\u80de\u5728\u4eba\u7c7b\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u4f4e\u6d78\u6da6\u53ef\u4ee5\u89e3\u91ca\u5b83\u4eec\u5bf9\u5b9e\u4f53\u7624\u8fdb\u5c55\u7684\u5f71\u54cd\u6709\u9650\u3002\u7136\u800c\uff0cNK\u7ec6\u80de\u4f3c\u4e4e\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u548c\u8840\u6db2\u6076\u6027\u80bf\u7624\u7279\u522b\u6709\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8f85\u52a9\u6027ILC\u4e9a\u7fa4<\/strong>\u53c2\u4e0e\u4eba\u7c7b\u764c\u75c7\u53d1\u751f\u53d1\u5c55\u7684\u8bc1\u636e\u6709\u9650\u3002\u5728\u4eba\u7c7b\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u60a3\u8005\u7684\u539f\u53d1\u80bf\u7624\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u7ec4\u7ec7\u4e2d\u5df2\u7ecf\u89c2\u5bdf\u5230ILC3<\/strong>\u7684\u6d78\u6da6\u3002\u4f46\u91cd\u8981\u7684\u662f\uff0c\u8f85\u52a9\u7c7bILC\u5728\u6076\u6027\u75be\u75c5\u4e2d\u7684\u529f\u80fd\u4ecd\u4e0d\u6e05\u695a\uff0c\u53ef\u80fd\u53d6\u51b3\u4e8e\u764c\u75c7\u7684\u7c7b\u578b\u548c\u5206\u671f\u3002<\/p>\n

\u672c\u7ae0\u7684\u91cd\u70b9<\/strong>\u662fILC\u5728\u68c0\u6d4b\u548c\u6d88\u9664\u65b0\u751f\u80bf\u7624\u4e2d\u7684\u4fdd\u62a4\u4f5c\u7528\uff0c\u8bf7\u8bfb\u8005\u53c2\u8003\u5176\u4ed6\u7efc\u8ff0\uff0c\u4ee5\u5b8c\u6574\u8ba8\u8bba\u8f85\u52a9\u6027ILC\u4fc3\u8fdb\u6216\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u76f8\u53cd\u7684\u4e24\u79cd\u80fd\u529b\u3002<\/p>\n

\u80bf\u7624\u5fae\u73af\u5883<\/strong>\u53ef\u80fd\u901a\u8fc7\u6291\u5236ILC\u7684\u6297\u80bf\u7624\u6d3b\u6027(\u5982\u5e72\u6270\u7d20-\u03b3\u7684\u91ca\u653e)\u6216\u901a\u8fc7\u5f71\u54cdILC\u7684\u53ef\u5851\u6027<\/strong>\u6765\u64cd\u7eb5ILC\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e00\u4e9bILC\u4e9a\u7fa4\u5e76\u4e0d\u7a33\u5b9a\uff0c\u8fd9\u53d6\u51b3\u4e8e\u7ec6\u80de\u56e0\u5b50<\/strong>\u6240\u5728\u7684\u5fae\u73af\u5883\uff0cNK\u7ec6\u80de\u53ef\u4ee5\u83b7\u5f97ILC1\u8868\u578b\uff0cILC2s\u53ef\u4ee5\u8f6c\u5316\u4e3aILC1\u6216ILC3s\uff0cILC3s\u53ef\u4ee5\u8f6c\u5316\u4e3aILC1\u3002\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5<\/strong>\u60a3\u8005\u8840\u6db2\u4e2dILC\u529f\u80fd\u548c\u4e9a\u578b\u7ec4\u6210\u5931\u8c03\u7684\u62a5\u9053\u652f\u6301\u4e86\u80bf\u7624\u53ef\u80fd\u901a\u8fc7\u8c03\u8282ILC\u9003\u8131\u514d\u75ab\u76d1\u89c6\u7684\u5047\u8bbe\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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ILC<\/strong>\u662f\u4e00\u4e2a\u6709\u8da3\u7684\u4e34\u5e8a\u9776\u70b9<\/strong>\uff0c\u56e0\u4e3a\u5b83\u4eec\u5bf9\u523a\u6fc0\u7acb\u5373<\/strong>\u4ea7\u751f\u53cd\u5e94\uff0c\u5e76\u4e14\u5b83\u4eec\u7684\u53cd\u5e94\u4e0d\u662f\u7531\u6297\u539f\u9a71\u52a8<\/strong>\u7684\u3002\u5b83\u4eec\u4ea7\u751f\u7684\u5927\u91cf\u7ec6\u80de\u56e0\u5b50<\/strong>\u53ef\u4ee5\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5524\u9192\u9ad3\u7cfb\u7ec6\u80de\u548c\u9002\u5e94\u6027\u6dcb\u5df4\u7ec6\u80de\u7684\u6297\u764c\u80fd\u529b\u3002<\/p>\n

\u7136\u800c\uff0c\u5728\u8fd9\u4e9b\u7ec6\u80de\u80fd\u591f\u6709\u6548\u5730\u5e94\u7528\u4e8e\u4e34\u5e8a\u4e4b\u524d\uff0c\u9700\u8981\u66f4\u597d\u5730\u4e86\u89e3\u8f85\u52a9\u7c7bILC<\/strong>\u7684\u529f\u80fd\u3001\u751f\u7269\u5b66\u7279\u6027\u548c\u53ef\u5851\u6027\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u64cd\u7eb5NK\u7ec6\u80de<\/strong>\u5df2\u7ecf\u6210\u4e3a\u764c\u75c7\u60a3\u8005\u975e\u5e38\u6709\u524d\u666f\u7684\u6cbb\u7597\u9009\u62e9\u3002\u5229\u7528NK\u7ec6\u80de\u6297\u80bf\u7624\u6d3b\u6027\u7684\u591a\u79cd\u7b56\u7565\u5df2\u7ecf\u5728\u5176\u4ed6\u7ae0\u8282\u6709\u63cf\u8ff0\uff0c\u5e76\u4e14\u662f\u672c\u5377\u7684\u53e6\u4e00\u7ae0\u7684\u4e3b\u9898\u3002<\/p>\n

\u91cd\u8981\u7684\u662f\uff0c\u76ee\u524d\u5f00\u53d1\u7684\u4e00\u4e9b\u9488\u5bf9T\u7ec6\u80de\u6216NK\u7ec6\u80de\u7684\u7b56\u7565\uff0c\u5982\u6297PD1\u5355\u6297\u3001NKG2D\u53cc\u7279\u5f02\u6027\u7ed3\u5408\u5206\u5b50\u6216\u7ec6\u80de\u56e0\u5b50\u8f93\u6ce8\u4e5f\u53ef\u80fd\u5f71\u54cdILC<\/strong>\u7684\u529f\u80fd\u3002\u968f\u7740\u6211\u4eec\u5bf9ILC\u5bb6\u65cf\u77e5\u8bc6\u7684\u589e\u52a0\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u4f5c\u7528\u53ef\u80fd\u4e5f\u4f1a\u6709\u6240\u63d0\u5347\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/section>\n
for Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 |<\/span> <\/span>Camille Guillerey and Mark J. Smyth<\/span><\/span><\/section>\n
\u7ffb\u8bd1 | \u90d1\u68a6\u6021 \u848b\u4fca\u535a \u5f90\u66fc\u65af<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u90ed\u5b50<\/span><\/span><\/section>\n
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\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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OncoLab\u5b66\u672f\u661f\u7403<\/strong>\u73b0\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9<\/strong>\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

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\u7528\u4e8eOncoLab\u8bfb\u8005\u4ea4\u6d41\u4e92\u52a9\u6c38\u4e45\u514d\u8d39
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u8282 \u65e5 DRAGON BOAT FESTIVAL DRAGON BOAT FESTIVAL  202…<\/p>\n","protected":false},"author":1,"featured_media":2597,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2603"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=2603"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2603\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/2597"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=2603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=2603"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=2603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}