{"id":2610,"date":"2022-06-28T22:46:46","date_gmt":"2022-06-28T14:46:46","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2022\/06\/28\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac10%e7%ab%a0%ef%bc%9a%e9%aa%a8%e9%ab%93%e6%ba%90%e6%80%a7%e6%8a%91%e5%88%b6%e6%80%a7%e7%bb%86%e8%83%9emdscs%e7%9a%84%e7%94%9f%e7%89%a9%e5%ad%a6\/"},"modified":"2022-06-28T22:46:46","modified_gmt":"2022-06-28T14:46:46","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac10%e7%ab%a0%ef%bc%9a%e9%aa%a8%e9%ab%93%e6%ba%90%e6%80%a7%e6%8a%91%e5%88%b6%e6%80%a7%e7%bb%86%e8%83%9emdscs%e7%9a%84%e7%94%9f%e7%89%a9%e5%ad%a6","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2022\/06\/28\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac10%e7%ab%a0%ef%bc%9a%e9%aa%a8%e9%ab%93%e6%ba%90%e6%80%a7%e6%8a%91%e5%88%b6%e6%80%a7%e7%bb%86%e8%83%9emdscs%e7%9a%84%e7%94%9f%e7%89%a9%e5%ad%a6\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c10\u7ae0\uff1a\u9aa8\u9ad3\u6e90\u6027\u6291\u5236\u6027\u7ec6\u80de(MDSCs)\u7684\u751f\u7269\u5b66\u7279\u6027\uff08\u4e0a\uff09"},"content":{"rendered":"
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10.1  \u7b80\u4ecb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u80bf\u7624\u8fdb\u5c55\u4e0e\u9aa8\u9ad3\u7ec6\u80de\u7684\u75c5\u53d8\u6709\u5173\uff0c\u9ad3\u7cfb\u6765\u6e90\u7684\u6291\u5236\u7ec6\u80de(MDSCs)<\/strong>\u73b0\u5728\u5df2\u88ab\u8bc1\u5b9e\u662f\u8c03\u8282\u764c\u75c7\u514d\u75ab\u53cd\u5e94<\/strong>\u7684\u5173\u952e\u56e0\u7d20\u3002MDSCs\u4ee3\u8868\u4e00\u7ec4\u6269\u589e\u7684\u3001\u5f02\u8d28\u7684\u672a\u6210\u719f\u9ad3\u7cfb\u7ec6\u80de\uff0c\u4e0e\u764c\u75c7\u60a3\u8005\u7684\u4e0d\u826f\u9884\u540e\u548c\u5b58\u6d3b\u7387\u6709\u5173\u3002<\/p>\n

MDSCs<\/strong>\u5177\u6709\u5f3a\u5927\u7684\u514d\u75ab\u6291\u5236<\/strong>\u6d3b\u6027\uff0c\u5bf9\u4e8e\u80bf\u7624\u7684\u751f\u957f\u6709\u4fc3\u8fdb\u4f5c\u7528\u3002\u6b64\u5916\uff0cMDSCs\u8fd8\u4e0e\u4fc3\u8fdb\u8840\u7ba1\u5f62\u6210<\/strong>\u548c\u80bf\u7624\u8f6c\u79fb<\/strong>\u6709\u5173\u3002\u5f88\u660e\u663e\uff0cMDSCs\u5728\u764c\u75c7\u4e2d\u6709\u8bb8\u591a\u4f5c\u7528\uff0c\u7136\u800c\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2dMDSCs\u5bf9 T \u7ec6\u80de<\/strong>\u514d\u75ab\u53cd\u5e94\u7684\u6291\u5236\u662f\u5b83\u4eec\u7684\u91cd\u8981\u6807\u5fd7\uff0c\u4e5f\u662f\u8bb8\u591a\u7814\u7a76\u7684\u91cd\u70b9\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u4e86\u89e3 MDSC \u7684\u751f\u7269\u5b66\u7279\u6027<\/strong>\uff0c\u53ef\u4ee5\u5236\u5b9a\u6cbb\u7597\u7b56\u7565<\/strong>\uff0c\u5e76\u4e14\u671f\u671b\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u9776\u5411\u8fd9\u4e9b\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10.2 \u5c0f\u9f20\u548c\u4ebaMDSCs\u7684\u7279\u6027<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\uff0cMDSCs\u662f\u9ad3\u7cfb\u6765\u6e90\u7684\u5f02\u8d28\u6027\u7ec6\u80de\uff0c\u8868\u8fbe\u9ad3\u7cfb\u5206\u5316\u6807\u8bb0\u7269Gr-1(\u8c37\u80f1\u7518\u80bd\u8fd8\u539f\u9176)<\/strong>\u548cCD11b(\u03b1M\u6574\u5408\u7d20)<\/strong>\u6807\u8bb0\u7269 (Fig.10.1<\/span>)\u3002<\/p>\n

MDSC \u4e9a\u7fa4\u5df2\u6839\u636e GR1 \u8868\u8fbe\u5f3a\u5ea6<\/strong>\uff08GR1low<\/sup>\u3001GR1int<\/sup> \u548c GR1bright<\/sup>\uff09\u4e0e\u5176\u4ed6\u8868\u578b\u6807\u5fd7\u7269\uff08\u4f8b\u5982 F4\/F80\uff08\u5de8\u566c\u7ec6\u80de\u6807\u5fd7\u7269\uff09<\/strong>\u6216 MHC-II<\/strong>\uff08\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269 II \u7c7b\uff09\uff09\u6765\u8fdb\u884c\u9274\u5b9a\u3002<\/p>\n

\u7136\u800c\uff0cGR1 <\/strong>\u7531\u4e24\u4e2a\u8868\u4f4d Ly6C<\/strong> \u548c Ly6G <\/strong>\u7ec4\u6210\uff0c\u53ef\u4ee5\u88ab\u4e0d\u540c\u7684\u6297\u4f53\u68c0\u6d4b\u5230\u3002\u8fd9\u5bfc\u81f4\u4e86\u4e24\u4e2a\u4e0d\u540c\u7684MDSC\u4e9a\u7fa4<\/strong>\u7684\u9274\u5b9a\uff1a\u7c92\u7ec6\u80de\u6216\u591a\u5f62\u6838\u7ec6\u80de<\/strong>(G-\u6216PMN-MDSCs\uff0cCD11b+<\/sup>Ly6G+<\/sup>Ly6Clow<\/sup>)\u548c\u5355\u6838\u7ec6\u80de<\/strong>(M-MDSC\uff0cCD11b+<\/sup>Ly6G\u2212<\/sup>Ly6Chigh<\/sup>)\uff1b\u8fd9\u4e9b\u7ec6\u80de\u5728\u5f62\u6001\u548c\u8868\u578b\u4e0a\u5206\u522b\u4e0e\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u76f8\u4f3c (Fig.10.1<\/span>)\u3002<\/p>\n

\u5728\u5927\u591a\u6570\u764c\u75c7\u7c7b\u578b\u4e2d\uff0cPMN-MDSCs<\/strong>\u662f\u6700\u4e30\u5bcc<\/strong>\u7684\u7fa4\u4f53\uff0c\u5360\u6240\u6709MDSCs\u768470%<\/strong>\u4ee5\u4e0a\uff0c\u800cM-MDSCs<\/strong>\u662f\u7b2c\u4e8c\u4e30\u5bcc<\/strong>\u7684\u7fa4\u4f53\u3002\u6b64\u5916\uff0c\u5728\u8fd9\u4e9bMDSC\u4e9a\u7fa4\u4e2d\uff0c\u6709\u4e00\u4e2a\u4e0d\u52305%\u7684\u5c0f\u7fa4\u4f53\uff0c\u5176\u4e2d\u5305\u62ec\u76ee\u524d\u7814\u7a76\u7684\u7956\u7ec6\u80de\u548c\u524d\u4f53\u7ec6\u80de\u7684\u6df7\u5408\u7269\u3002\u5c0f\u9f20MDSCs\u5728\u66b4\u9732\u4e8e\u80bf\u7624\u884d\u751f\u56e0\u5b50\u540e\u5728\u9aa8\u9ad3\u4e2d\u751f\u6210\uff0c\u5e76\u4e3b\u8981\u805a\u96c6\u5728\u5916\u5468\u8840\u3001\u813e\u3001\u809d\u3001\u80ba\u548c\u80bf\u7624\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 10.1<\/span> MDSCs\u7684\u8d77\u6e90\u3002\u5728\u9aa8\u9ad3\u4e2d\uff0c\u9020\u8840\u5e72\u7ec6\u80de(HSC)\u5206\u5316\u4e3a\u666e\u901a\u9ad3\u7cfb\u7956\u7ec6\u80de(CMP)\uff0c\u7136\u540e\u5206\u5316\u4e3a\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u7956\u7ec6\u80de(GMP)\uff0c\u5f62\u6210\u4ee5\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u524d\u4f53\u4e3a\u4e3b\u7684\u672a\u6210\u719f\u9ad3\u7cfb\u7ec6\u80de\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u672a\u6210\u719f\u7684\u9ad3\u6837\u7ec6\u80de\u5206\u5316\u4e3a\u5de8\u566c\u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de(\u9ed1\u8272\u7bad\u5934)\u3002\u7136\u800c\uff0c\u5728\u764c\u75c7\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4ea7\u751f\u7684\u751f\u957f\u56e0\u5b50\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u6539\u53d8\u4e86\u9aa8\u9ad3\u4e2d\u7684\u9aa8\u9ad3\u751f\u6210\u3002\u8fd9\u4e9b\u80bf\u7624\u884d\u751f\u56e0\u5b50\u963b\u6b62\u672a\u6210\u719f\u7684\u9ad3\u6837\u7ec6\u80de\u5206\u5316\u4e3a\u5b8c\u5168\u6210\u719f\u7684\u7ec6\u80de\uff0c\u9020\u6210\u75c5\u7406\u6027\u6fc0\u6d3b\u7684\u672a\u6210\u719f\u5355\u6838\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u805a\u96c6\uff0c\u5206\u522b\u79f0\u4e3aM-MDSCs\u548cPMN-MDSCs(\u7ea2\u8272\u7bad\u5934)\u3002\u9664\u4e86\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2dMDSCs\u7684\u6269\u589e\u5916\uff0c\u8fd9\u4e9b\u7ec6\u80de\u8fd8\u83b7\u5f97\u4e86\u5f3a\u5927\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0cM-MDSCs\u5206\u5316\u4e3aTAMs\uff0c\u5177\u6709\u76f8\u4f3c\u7684\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4eba\u7c7b\u4e2d\uff0cMDSCs\u4e3b\u8981\u5728\u5916\u5468\u8840<\/strong>\u5355\u4e2a\u6838\u7ec6\u80de(PBMC)\u7ec4\u5206\u4e2d\u88ab\u9274\u5b9a\u548c\u7814\u7a76\u3002\u7136\u800c\uff0c\u4eba\u7c7b\u6ca1\u6709 Gr-1 \u6297\u539f<\/strong>\uff0c\u8fd9\u4f7f\u5f97\u5c0f\u9f20\u548c\u4eba\u7c7b MDSC \u4e4b\u95f4\u7684\u76f4\u63a5\u6bd4\u8f83\u53d8\u5f97\u56f0\u96be<\/strong>\u3002<\/p>\n

PMN-MDSCs<\/strong>\u88ab\u5b9a\u4e49\u4e3aCD11b+<\/sup>CD14\u2212<\/sup>CD15+<\/sup>\u6216CD11b+<\/sup>CD14\u2212<\/sup>CD66b+<\/sup>\uff0c\u800cM-MDSC<\/strong>\u88ab\u5b9a\u4e49\u4e3aCD11b+<\/sup>CD14+<\/sup>HLA–<\/sup>DR\u2212<\/sup>\/lo<\/sup>CD15\u2212<\/sup>\u3002\u6709\u4e00\u5c0f\u7fa4MDSCs\uff0c\u5176\u7279\u5f81\u4e3aLIN\u2212<\/sup>(\u5305\u62ecCD3\u3001CD14\u3001CD15\u3001CD19\u548cCD56)HLA–<\/sup>DR\u2212CD33+<\/sup>\u7ec6\u80de\uff0c\u8fd9\u4e2a\u5305\u542b\u8f83\u4e0d\u6210\u719f\u8868\u578b\u7684\u7fa4\u4f53\u88ab\u5b9a\u4e49\u4e3a\u201c\u65e9\u671fMDSCs<\/strong>(e-MDSCs)\u201d\u3002 <\/p>\n

\u76ee\u524d\uff0c\u5b9a\u4e49\u548c\u8868\u5f81\u4eba\u7c7bMDSCs<\/strong>(\u5305\u62ecPMN-MDSCs\u3001M-MDSCs\u548ce-MDSCs)\u7684\u6700\u4f4e\u8981\u6c42<\/strong>\u5e94\u8be5\u9075\u5faa\u8868\u578b\u6807\u51c6\uff0c\u6839\u636e\u8fd9\u4e9b\u6807\u51c6\u4ee5\u53caHLA-DR<\/strong>(MHC\u2161\u7c7b\u5206\u5b50)\u7684\u8868\u8fbe\u5c06M-MDSCs\u4ece\u5355\u6838\u7ec6\u80de\u4e2d\u5206\u79bb\u51fa\u6765\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4ece\u6b63\u5e38\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\u5206\u79bbPMN-MDSCs\u7684\u552f\u4e00\u65b9\u6cd5\u662f\u4f7f\u7528\u6807\u51c6\u7684Ficoll\u68af\u5ea6<\/strong>\u8fdb\u884c\u68af\u5ea6\u79bb\u5fc3\u3002PMN-MDSCs<\/strong>\u5728\u4f4e\u5bc6\u5ea6\u7ec4\u5206(PBMC)\u4e2d\u5bcc\u96c6\uff0c\u800c\u4e2d\u6027\u7c92\u7ec6\u80de\u5219\u53ef\u4ee5\u5728\u9ad8\u5bc6\u5ea6\u7ec4\u5206\u4e2d\u88ab\u68c0\u6d4b\u5230\u3002<\/p>\n

\u6700\u8fd1\uff0c\u51dd\u96c6\u7d20\u578b\u6c27\u5316\u578b\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f531(LOX-1<\/strong>)\u5df2\u88ab\u786e\u5b9a\u4e3a\u4eba\u7c7bPMN-MDSCs\u7684\u6f5c\u5728\u6807\u5fd7\u7269\u3002\u4e2d\u6027\u7c92\u7ec6\u80de\u8868\u9762LOX-1\u7684\u8868\u8fbe\u53ef\u7528\u4e8e\u76f4\u63a5\u9274\u5b9a\u8840\u6db2\u548c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u53d1\u73b0\u7684PMN-MDSCs<\/strong>\u3002<\/p>\n

\u6b64\u5916\uff0c\u4ece\u764c\u75c7\u60a3\u8005\u8840\u6db2\u4e2d\u5206\u79bb\u51fa\u7684LOX-1<\/strong>+<\/sup>\u4e2d\u6027\u7c92\u7ec6\u80de\u53ef\u6291\u5236T\u7ec6\u80de\u589e\u6b96\uff0c\u800cLOX-1\u2212<\/sup>\u4e2d\u6027\u7c92\u7ec6\u80de\u5219\u6ca1\u6709\u6291\u5236\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10.3 MDSC\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u673a\u5236<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8981\u5b8c\u5168\u9274\u5b9a\u9ad3\u7cfb\u7ec6\u80de\u4e3aMDSCs\uff0c\u9700\u8981\u6d4b\u8bd5\u5b83\u4eec\u7684\u529f\u80fd\u6d3b\u6027<\/strong>\uff0c\u8fd9\u901a\u5e38\u662f\u901a\u8fc7\u4f53\u5916\u6291\u5236\u8bd5\u9a8c<\/strong>\u6765\u5b9e\u73b0\u7684\uff0c\u4f53\u5916\u6291\u5236\u8bd5\u9a8c\u68c0\u6d4b\u4e86\u5b83\u4eec\u6291\u5236\u8377\u7624\u5bbf\u4e3b\u4e2d\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u7684\u80fd\u529b\u3002<\/p>\n

\u6fc0\u6d3b\u7684MDSCs\u53ef\u76f4\u63a5\u6291\u5236NK\u548cB\u7ec6\u80de<\/strong>\u53ca\u5176\u4e3b\u8981\u9776\u70b9T\u7ec6\u80de<\/strong>\u3002MDSCs\u7684\u514d\u75ab\u6291\u5236\u6d89\u53ca\u591a\u79cd\u673a\u5236\uff0c\u5982\u589e\u52a0\u7cbe\u6c28\u9178\u91761(Arg1<\/strong>)\u548c\u8bf1\u5bfc\u578b\u4e00\u6c27\u5316\u6c2e\u5408\u9176(iNOS<\/strong>)\u7684\u4ea7\u751f\uff0c\u589e\u52a0\u6d3b\u6027\u6c27<\/strong>\u548c\u6c2e\u7269\u8d28<\/strong>(ROS\u548c\u8fc7\u6c27\u4e9a\u785d\u9178\u76d0\uff0cPNT)\u4ee5\u53ca\u5176\u4ed6\u514d\u75ab\u6291\u5236\u56e0\u7d20\u7684\u4ea7\u751f\u3002<\/p>\n

MDSCs\u4e2dArg1<\/strong>\u7684\u4e0a\u8c03\u5bfc\u81f4L-\u7cbe\u6c28\u9178<\/strong>(T\u7ec6\u80de\u589e\u6b96\u6240\u9700\u7684\u4e00\u79cd\u5fc5\u9700\u6c28\u57fa\u9178)\u8017\u5c3d\u5e76\u8f6c\u5316\u4e3a\u5c3f\u7d20<\/strong>\u548cL-\u9e1f\u6c28\u9178<\/strong>\u3002\u5728L-\u7cbe\u6c28\u9178\u7684\u9650\u5236\u4e0b\uff0cMDSCs\u4e2diNOS<\/strong>\u7684\u4e0a\u8c03\u5bfc\u81f4\u4e00\u6c27\u5316\u6c2e(NO<\/strong>)\u7684\u4ea7\u751f\uff0cNO\u4e0e\u8d85\u6c27\u5316\u7269\u53cd\u5e94\u751f\u6210PNT<\/strong>\u3002MDSCs\u4ea7\u751fPNT\u4f1a\u5bfc\u81f4T\u7ec6\u80de\u53d7\u4f53(TCR)\u7684\u785d\u5316\u548c\u4e9a\u785d\u57fa\u5316<\/strong>\uff0c\u4ece\u800c\u7834\u574f\u6f5c\u5728\u7684CD8+<\/sup>T\u7ec6\u80de-\u6297\u539f\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4T\u7ec6\u80de\u8010\u53d7\u3002<\/p>\n

\u6b64\u5916\uff0cPNT\u901a\u8fc7\u785d\u5316<\/strong>T\u7ec6\u80de\u7279\u5f02\u6027\u8d8b\u5316\u56e0\u5b50<\/strong>\uff0c\u5982CCL2<\/strong>\uff0c\u51cf\u5c11\u6297\u539f\u80bd\u4e0e\u80bf\u7624\u7ec6\u80de\u4e0aMHC\u5206\u5b50\u7684\u7ed3\u5408\uff0c\u963b\u6b62T\u7ec6\u80de\u8fc1\u79fb\u3002<\/p>\n

\u53e6\u4e00\u79cd\u6291\u5236T\u7ec6\u80de\u53cd\u5e94\u7684\u673a\u5236\u662fMDSCs\u4ea7\u751fROS<\/strong>\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u884d\u751f\u56e0\u5b50\u4ea7\u751f\u7684MDSCs\u53ef\u4ea7\u751f\u9ad8\u6c34\u5e73\u7684ROS\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u6291\u5236\u8fd9\u4e9b\u7ec6\u80de\u7684\u6d3b\u6027\u3002<\/p>\n

\u4ee5\u4e0a\u662fMDSCs\u514d\u75ab\u6291\u5236\u7684\u4e3b\u8981\u673a\u5236\uff0c\u4f46\u4e5f\u6709\u5176\u4ed6\u51e0\u79cd\u56e0\u7d20\u53c2\u4e0e\u5176\u4e2d\uff0c\u5305\u62ec\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2(TGF-\u03b2<\/strong>)\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-10(IL-10<\/strong>)\u3001\u73af\u6c27\u5408\u9176-2(COX-2<\/strong>)\u3001\u5432\u54da\u80fa2\uff0c3-\u53cc\u52a0\u6c27\u9176(IDO<\/strong>)\u7b49\u3002<\/p>\n

MDSCs<\/strong>\u4ea7\u751f\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50<\/strong>\u4e3b\u8981\u4e3a\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u548c\u767d\u7ec6\u80de\u4ecb\u7d20-10<\/strong>\u3002\u5c3d\u7ba1\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u88ab\u8bc1\u660e\u662f\u7531\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u7684\uff0c\u4f46MDSCs\u4ea7\u751f\u7684\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u6291\u5236\u4e86\u8377\u7624\u5c0f\u9f20\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n

MDSCs\u4ea7\u751f\u5927\u91cf\u7684IL-10\uff0c\u901a\u8fc7\u6291\u5236T\u7ec6\u80de\u7684\u6fc0\u6d3b\u6765\u524a\u5f31\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n

\u6b64\u5916\uff0cMDSCs\u8fd8\u8868\u8fbe\u4e86\u51e0\u79cd\u9176\uff0c\u8fd9\u4e9b\u9176\u4e0eT\u7ec6\u80de\u529f\u80fd\u6240\u5fc5\u9700\u7684<\/strong>\u8425\u517b\u56e0\u5b50\u7684\u8017\u7aed<\/strong>\u6709\u5173\u3002\u5728\u4fc3\u708e\u5206\u5b50\u7684\u523a\u6fc0\u4e0b\uff0cCOX-2<\/strong>\u88ab\u6fc0\u6d3b\u5e76\u8bf1\u5bfcMDSCs\u4e2d\u7684Arg1\u6d3b\u6027<\/strong>\u3002\u5176\u4ed6\u7814\u7a76\u8868\u660eMDSCs\u4e2dIDO<\/strong>\u7684\u8868\u8fbe\u901a\u8fc7\u8017\u5c3dl-\u8272\u6c28\u9178<\/strong>\u548c\u8bf1\u5bfc\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684T\u7ec6\u80de\u51cb\u4ea1<\/strong>\u6765\u6291\u5236T\u7ec6\u80de\u529f\u80fd\u3002<\/p>\n

MDSCs\u8fd8\u901a\u8fc7\u8017\u5c3d\u80bf\u7624\u4e2d\u7684\u534a\u80f1\u6c28\u9178<\/strong>\u548c\u963b\u788dT\u7ec6\u80de\u7684\u6fc0\u6d3b\u6765\u963b\u65adT\u7ec6\u80de\u7684\u529f\u80fd\u3002\u6b64\u5916\uff0cMDSCs\u8fd8\u5177\u6709\u8bf1\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de(Treg)\u6269\u589e<\/strong>\u7684\u80fd\u529b\u3002<\/p>\n

\u5927\u591a\u6570\u4e0eMDSC\u529f\u80fd\u76f8\u5173\u7684\u6291\u5236\u673a\u5236\u5e76\u4e0d\u662f\u540c\u65f6\u8d77\u4f5c\u7528\u7684\uff0c\u5e76\u4e14\u4f9d\u8d56\u4e8eMDSC\u7684\u7c7b\u578b\u3001\u80bf\u7624\u7684\u7c7b\u578b\u548c\u7ec6\u80de\u7684\u4f4d\u7f6e<\/strong>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1\u7684\u51e0\u9879\u7814\u7a76\u8868\u660e\uff0cPMN-MDSCs\u548cM-MDSCs<\/strong>\u7684\u6bd4\u4f8b\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u8fd9\u4e24\u79cd\u7ec6\u80de\u5229\u7528\u4e0d\u540c\u7684\u673a\u5236<\/strong>\u6291\u5236T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n

\u4f8b\u5982\uff0cM-MDSCs<\/strong>\u5177\u6709\u4ee5\u6297\u539f\u7279\u5f02\u6027\u548c\u975e\u7279\u5f02\u6027\u65b9\u5f0f\u6291\u5236T\u7ec6\u80de\u6fc0\u6d3b\u7684\u80fd\u529b\u3002M-MDSCs\u5bf9T\u7ec6\u80de\u53cd\u5e94\u7684\u6291\u5236\u4e0eiNOS\u7684\u8868\u8fbe\u589e\u52a0\u548cNO\u7684\u4ea7\u751f\u6709\u5173\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0cPMN-MDSCs<\/strong>\u4e3b\u8981\u4ee5\u6297\u539f\u7279\u5f02\u6027\u7684\u65b9\u5f0f\u6291\u5236\u514d\u75ab\u5e94\u7b54\uff0c\u8bf1\u5bfc\u5bbf\u4e3b\u5bf9CD8+<\/sup>T\u7ec6\u80de\u7684\u8010\u53d7\u3002PMN-MDSCs\u7684\u514d\u75ab\u6291\u5236\u4e0eArg1\u7684\u8868\u8fbe\u589e\u52a0<\/strong>\u4ee5\u53caROS\u548cPNT\u7684\u9ad8\u6c34\u5e73<\/strong>\u76f8\u5173\u3002<\/p>\n

\u867d\u7136PMN-MDSCs\u5728\u8377\u7624\u5bbf\u4e3b\u4e2d\u6bd4M-MDSCs\u66f4\u4e30\u5bcc\uff0c\u4f46\u76f8\u6bd4\u4e8eM-MDSCs\uff0c\u5728\u6bcf\u4e2a\u7ec6\u80de\u7684\u57fa\u7840\u4e0a\uff0cPMN-MDSCs<\/strong>\u7684\u514d\u75ab\u6291\u5236\u7a0b\u5ea6\u8981\u4f4e\u3002\u4f4d\u7f6e\u4e5f\u662f\u51b3\u5b9aMDSCs\u6291\u5236\u5f3a\u5ea6\u7684\u91cd\u8981\u56e0\u7d20\u3002<\/p>\n

\u8fd1\u5e74\u6765\u5df2\u6709\u5927\u91cf\u8bc1\u636e\u8868\u660e\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684MDSCs<\/strong>\u6bd4\u5916\u5468\u6dcb\u5df4\u5668\u5b98\u548c\u5916\u5468\u8840\u6db2\u4e2d\u7684MDSCs\u66f4\u5177\u514d\u75ab\u6291\u5236\u6027<\/strong>\u3002\u73b0\u5728\u6709\u786e\u5207\u7684\u8bc1\u636e\u8868\u660e\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u53d1\u73b0\u7684\u4f4e\u6c27(\u7f3a\u6c27)\u6c34\u5e73<\/strong>\u5bf9MDSCs\u6291\u5236\u6d3b\u6027<\/strong>\u589e\u5f3a\u6709\u8c03\u8282\u4f5c\u7528\u3002<\/p>\n

\u7136\u800c\uff0c\u8fd8\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u6765\u66f4\u597d\u5730\u4e86\u89e3\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2dMDSCs\u7684\u5f3a\u5927\u6291\u5236\u6d3b\u6027\u8fd8\u6d89\u53ca\u5230\u54ea\u4e9b\u5176\u4ed6\u80bf\u7624\u76f8\u5173\u56e0\u7d20\u548c\u673a\u5236(Fig.10.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig. 10.2 <\/span>MDSCs\u9aa8\u5728\u80bf\u7624\u4e2d\u7684\u514d\u75ab\u6291\u5236\u673a\u5236\u3002\u5728\u80bf\u7624\u4e2d\uff0cM-MDSCs\u548cPMN-MDSCs\u90fd\u53ef\u4ee5\u901a\u8fc7\u4e0d\u540c\u7684\u673a\u5236\u6291\u5236\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u3002\u5728\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u8fd9\u4e9b\u673a\u5236\u53d7\u5230\u51e0\u79cd\u8f6c\u5f55\u56e0\u5b50\u548c\u9176\u7684\u8c03\u8282\uff0c\u4ee5\u53ca\u5185\u8d28\u7f51\u5e94\u6fc0\u53cd\u5e94\u7684\u6fc0\u6d3b\u3002(a)\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0cHIF-1\u03b1\u4e0a\u8c03\u53ef\u8bf1\u5bfcM-MDSCs\u5206\u5316\u4e3aTAMs\uff0c\u8fd9\u79cd\u5206\u5316\u4f9d\u8d56\u4e8eSTAT3\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0cTAMS\u901a\u8fc7\u6fc0\u6d3bArg1\u6765\u9694\u79bb\u7cbe\u6c28\u9178\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u53cd\u5e94\u3002(b)M-MDSCs\u7ade\u4e89T\u548cB\u7ec6\u80de\u7684\u5fc5\u9700\u6c28\u57fa\u9178\uff0c\u5305\u62ec\u7cbe\u6c28\u9178\u548c\u534a\u80f1\u6c28\u9178\u3002(c)M-MDSCs\u514d\u75ab\u6291\u5236\u7684\u4e3b\u8981\u673a\u5236\u662fiNOS\u7684\u8868\u8fbe\u548cNO\u7684\u91ca\u653e\u3002NO\u7684\u91ca\u653e\u5bfc\u81f4T\u7ec6\u80de\u53d7\u4f53\u7684\u785d\u5316\u6216\u4e9a\u785d\u5316\uff0c\u4ee5\u53ca\u5438\u5f15T\u7ec6\u80de\u7684\u8d8b\u5316\u56e0\u5b50\u3002(d)M-MDSCs\u548cPMN-MDSCs\u5747\u53ef\u91ca\u653eIL-10\u548c\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\uff0c\u8bf1\u5bfc\u6297\u539f\u7279\u5f02\u6027Treg\u7684\u5f62\u6210\u548c\u6269\u589e\uff0c\u53ef\u80fd\u9700\u8981CD40-CD40L\u76f8\u4e92\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\u7684\u91ca\u653e\u4e0eMDSCs\u5bf9NK\u7ec6\u80de\u7684\u6291\u5236\u6709\u5173\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0cMDSC\u4e9a\u7fa4\u4e0a\u8c03PDL-1\u7684\u8868\u8fbe\uff0c\u800cPDL-1\u4e0eT\u7ec6\u80de\u4e0a\u7684PD-1\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002(e)\u4e0eM-MDSCs\u7c7b\u4f3c\uff0cPMN-MDSCs\u901a\u8fc7\u6d88\u8017\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7cbe\u6c28\u9178\u548c\u534a\u80f1\u6c28\u9178\u6765\u6291\u5236T\u7ec6\u80de\u53cd\u5e94\u3002(f\uff0cg)PMN-MDSCs\u7684\u7279\u5f81\u662f\u91ca\u653e\u6d3b\u6027\u6c2e\u6216\u6c27\u7269\u8d28\u3002(f)PMN-MDSCs\u4ea7\u751fPNT\u5bfc\u81f4TCR\u94fe\u785d\u5316\u6216\u4e9a\u785d\u5316\uff0c\u6291\u5236T\u7ec6\u80de\u589e\u6b96\u3002MDSCs\u91ca\u653e\u8fc7\u6c27\u4e9a\u785d\u9178\u76d0\u7684\u53e6\u4e00\u4e2a\u91cd\u8981\u4f5c\u7528\u662f\u4fee\u9970\u8d8b\u5316\u7269\u8d28CCL2\uff0c\u5f71\u54cdT\u7ec6\u80de\u7684\u8fc1\u79fb\u3002(g)NOx\u7684\u6fc0\u6d3b\u4e5f\u662f\u80bf\u7624\u76f8\u5173\u7684PMN-MDSCs\u4ea7\u751f\u6d3b\u6027\u6c27\u589e\u52a0\u7684\u539f\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/section>\n
f<\/span>or Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | Kevin Alicea-Torres and Dmitry I. Gabrilovich<\/span><\/section>\n
\u7ffb\u8bd1 |   \u90ed\u5b50 \u848b\u4fca\u535a \u5f90\u66fc\u65af<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u6f58\u541b\u541b<\/span><\/span><\/section>\n
\u521d\u5ba1 | \u5ed6\u5a9b \u4efb\u632f\u9633<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

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\u2589  \u5f3a\u70c8\u63a8\u8350<\/strong><\/strong><\/p>\n

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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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