{"id":2683,"date":"2022-09-01T15:31:48","date_gmt":"2022-09-01T07:31:48","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2022\/09\/01\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac12%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%83%85%e5%86%b5%e4%b8%8b%e4%bb%a5%e5%8f%8a%e6%b2%bb%e7%96%97%e5%bc%95%e8%b5%b7%e7%9a%84%e5%85%8d-2\/"},"modified":"2022-09-01T15:31:48","modified_gmt":"2022-09-01T07:31:48","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac12%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%83%85%e5%86%b5%e4%b8%8b%e4%bb%a5%e5%8f%8a%e6%b2%bb%e7%96%97%e5%bc%95%e8%b5%b7%e7%9a%84%e5%85%8d-2","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2022\/09\/01\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac12%e7%ab%a0%ef%bc%9a%e8%87%aa%e7%84%b6%e6%83%85%e5%86%b5%e4%b8%8b%e4%bb%a5%e5%8f%8a%e6%b2%bb%e7%96%97%e5%bc%95%e8%b5%b7%e7%9a%84%e5%85%8d-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c12\u7ae0\uff1a\u81ea\u7136\u60c5\u51b5\u4e0b\u4ee5\u53ca\u6cbb\u7597\u5f15\u8d77\u7684\u514d\u75ab\u76d1\u89c6\u4e2d\u764c\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027\u5e94\u6fc0\u548c\u6b7b\u4ea1\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\u8bf7\u70b9\u51fb\u94fe\u63a5\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c12\u7ae0\uff1a\u81ea\u7136\u60c5\u51b5\u4e0b\u4ee5\u53ca\u6cbb\u7597\u5f15\u8d77\u7684\u514d\u75ab\u76d1\u89c6\u4e2d\u764c\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027\u5e94\u6fc0\u548c\u6b7b\u4ea1\uff08\u4e0a\uff09<\/span><\/a>\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9499\u7f51\u86cb\u767d<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9499\u7f51\u86cb\u767d(CALR)<\/strong>\u662f\u5185\u8d28\u7f51(ER)\u7ba1\u8154\u4e2d\u542b\u91cf\u6700\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\u3002\u5728ICD\u4e2d<\/strong>\uff0c\u4e00\u90e8\u5206CALR\u6613\u4f4d\u5230\u8d28\u819c\u8868\u9762(\u5e76\u4e14\u53e6\u4e00\u90e8\u5206 CALR\u4e5f\u53ef\u80fd\u4f1a\u5206\u6ccc\u51fa\u53bb)\u3002<\/p>\n

CALR\u66b4\u9732\u7684\u590d\u6742\u673a\u5236\u4e0e\u771f\u6838\u7ec6\u80de\u8d77\u59cb\u56e0\u5b50-2\u03b1(eIF2\u03b1)\u5728\u5185\u8d28\u7f51\u5e94\u6fc0\u53cd\u5e94\u4e2d\u7684\u78f7\u9178\u5316\u6709\u5173\uff0c\u5185\u8d28\u7f51\u5e94\u6fc0\u53cd\u5e94\u6700\u7ec8\u5bfc\u81f4eIF2PK2(\u6700\u4e3a\u4eba\u6240\u77e5\u7684\u662fPKR)\u548cEIF2K3(\u6700\u4e3a\u4eba\u6240\u77e5\u7684\u662fPERK)\u7684\u6fc0\u6d3b\u548c\/\u6216\u76f8\u5e94\u78f7\u9178\u9176\u7684\u6291\u5236(\u7531\u50ac\u5316\u4e9a\u57fapp1\u548c\u8c03\u8282\u4e9a\u57faGADD34\u7ec4\u6210)\u3002<\/p>\n

\u5728eIF2\u03b1\u78f7\u9178\u5316\u4e0b\u6e38\uff0c\u534a\u80f1\u6c28\u9178\u86cb\u767d\u9176<\/strong>(\u5c24\u5176\u662fcaspase-8\uff0cCASP8)\u88ab\u6fc0\u6d3b\uff0c\u9499\u7f51\u86cb\u767d\u901a\u8fc7\u5185\u8d28\u7f51-\u9ad8\u5c14\u57fa\u4f53\u8f6c\u8fd0<\/strong>\u548c\u53ef\u6eb6\u6027N-\u4e59\u57fa\u9a6c\u6765\u9170\u4e9a\u80fa\u654f\u611f\u56e0\u5b50\u9644\u7740\u53d7\u4f53\uff08SNARE\uff09\u4f9d\u8d56\u6027\u80de\u5410<\/strong>\u88ab\u8fd0\u8f93\u5230\u7ec6\u80de\u8868\u9762\uff0c\u8be5\u80de\u5410\u6d89\u53ca\u56ca\u6ce1\u76f8\u5173\u819c\u86cb\u767d1\uff08VAMP1<\/strong>\uff09\u548c\u7a81\u89e6\u4f53\u76f8\u5173\u86cb\u767d23\uff08SNAP23<\/strong>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u65e6\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\uff0cCALR<\/strong>\u5c31\u5145\u5f53\u4e00\u4e2a\u201ceat-me\u201d<\/strong>\u4fe1\u53f7\uff0c\u53ef\u4fc3\u8fdb\u80bf\u7624\u76f8\u5173\u6297\u539f<\/strong>\u8f6c\u79fb\u5230\u6811\u7a81\u72b6\u7ec6\u80de<\/strong>\uff0c\u56e0\u4e3a\u6811\u7a81\u72b6\u7ec6\u80de\u8868\u8fbeCALR\u53d7\u4f53\u5373\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u76f8\u5173\u86cb\u767d1(LRP1<\/strong>\uff0c\u6700\u8457\u540d\u7684\u662fCD91\uff1bFig12.3<\/span>)\u3002<\/p>\n

CALR\u53ef\u4ee5\u88abCD47<\/strong>\u5c40\u90e8\u62ee\u6297\uff0cCD47\u5728\u764c\u7ec6\u80de<\/strong>\u4e0a\u6709\u7ec4\u6210\u6027\u8868\u8fbe<\/strong>\uff0c\u53ef\u4ee5\u8d77\u5230\u201cdon\u2019t eat me\u201d<\/strong>\u4fe1\u53f7\u7684\u4f5c\u7528\u3002<\/p>\n

PERK\u3001CASP8\u3001CALR\u6216SNAP23\u7684\u4e0b\u8c03<\/strong>\u4ee5\u53cacaspases\u548c\u5185\u8d28\u7f51-\u9ad8\u5c14\u57fa\u4f53\u8f6c\u8fd0\u7684\u836f\u7269\u6291\u5236<\/strong>\u8db3\u4ee5\u5728\u4f53\u5185\u548c\u4f53\u5916\u7834\u574fICD\u3002<\/p>\n

\u76f8\u53cd\uff0c\u5728\u5316\u7597\u7684\u80cc\u666f\u4e0b\uff0c\u901a\u8fc7thapsigargin<\/strong>(\u6fc0\u6d3bPERK<\/strong>)\u6216PP1\u6291\u5236\u5242\u523a\u6fc0eIF2\u03b1\u78f7\u9178\u5316<\/strong>\u53ef\u4ee5\u523a\u6fc0CALR<\/strong>\u66b4\u9732\u5e76\u589e\u5f3a\u4f53\u5185\u7684\u6297\u764c\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u5c06CALR\u66b4\u9732\u9014\u5f84\u7f3a\u9677\u7684\u764c\u7ec6\u80de\u5305\u88ab\u91cd\u7ec4CALR\u86cb\u767d<\/strong>(\u8be5\u86cb\u767d\u53ef\u80fd\u901a\u8fc7\u5176\u51dd\u96c6\u7d20\u7ed3\u6784\u57df\u548c\u7cd6\u843c\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u7ed3\u5408\u5230\u8d28\u819c\u8868\u9762)\u53ef\u4fee\u590d\u7f3a\u9677\u7684ICD<\/span>\u3002\u540c\u6837\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u7624\u5185\u6ce8\u5c04CALR<\/strong>\u53ef\u4ee5\u589e\u5f3a\u5316\u7597\u8bf1\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u6539\u5584\u80bf\u7624\u7684\u751f\u957f\u6291\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6709\u5e7f\u6cdb\u7684\u8bc1\u636e\u8868\u660e\uff0c\u5728\u764c\u75c7\u60a3\u8005\u4f53\u5185\uff0cCALR\u7684\u8868\u8fbe\u548c\u66b4\u9732\u6709\u52a9\u4e8e\u4f53\u5185\u6297\u764c\u514d\u75ab\u76d1\u89c6<\/span>\u3002<\/p>\n

\u5728\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5(AML) <\/strong>\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)<\/strong>\u4e2d\uff0c\u7ec6\u80de\u5185CALR\u7684\u4f4e\u8868\u8fbe\u6c34\u5e73\u4e0e\u7ec6\u80de\u8868\u9762CALR\u7684\u4f4e\u8868\u8fbe\u4ee5\u53caeIF2\u03b1\u7684\u78f7\u9178\u5316\u6c34\u5e73\u964d\u4f4e\u6709\u5173\u3002<\/p>\n

\u5728AML<\/strong>\u4e2d\uff0cCALR\u86cb\u767d\u7684\u4f4e\u8868\u8fbe\u5bf9\u5316\u7597\u540e\u7684\u65e0\u8fdb\u5c55\u548c\u603b\u751f\u5b58\u671f\u6709\u8d1f\u9762\u5f71\u54cd\uff0c\u8fd9\u4e0eAML\u76f8\u5173\u80bf\u7624\u6297\u539f\u7684T\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\u5dee\u6709\u5173\u3002<\/p>\n

\u5728NSCLC<\/strong>\u4e2d\uff0c\u7ea615%\u7684\u60a3\u8005\u764c\u7ec6\u80de\u4e2d\u51e0\u4e4e\u68c0\u6d4b\u4e0d\u5230CALR\u86cb\u767d\uff0c\u8fd9\u4e0e\u9884\u540e\u4e0d\u826f\u3001DC-LAMP+<\/sup>\u6811\u7a81\u72b6\u7ec6\u80de\u548cCD8+<\/sup>T\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u51cf\u5c11\u6709\u5173\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728NSCLC\u9884\u540e\u65b9\u9762\uff0c\u4f4eCALR\u8868\u8fbe\u7684\u9884\u540e\u91cd\u8981\u6027\u751a\u81f3\u8d85\u8fc7\u4e86TNM\u5206\u671f<\/span>\uff0c\u8fd9\u610f\u5473\u7740CALRlow<\/sup> 1\u671fNSCLC\u60a3\u8005\u7684\u751f\u5b58\u7387\u6bd4CALRhigh <\/sup>3\u671f\u548c4\u671f\u60a3\u8005\u5dee\u3002<\/p>\n

\u8fd9\u4e9b\u7ed3\u8bba\u901a\u8fc7CALR\u86cb\u767d\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66<\/strong>\u68c0\u6d4b\u5728\u4e24\u4e2a\u4e0d\u540c\u7684NSCLC\u961f\u5217\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\uff0c\u6b64\u5916\u5728\u53e6\u5916\u4e00\u4e2aNSCLC\u961f\u5217\u4e2d\uff0c\u901a\u8fc7\u68c0\u6d4bCALR mRNA\u6c34\u5e73<\/strong>\u53ca\u5176\u4e0e<\/strong>\u53cd\u6620CTL\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u5b58\u5728\u7684\u57fa\u56e0\u7684\u76f8\u5173\u6027<\/strong>\uff0c\u4e5f\u5f97\u5230\u4e86\u4e00\u81f4\u7684\u7ed3\u679c\u3002<\/p>\n

\u540c\u6837\uff0c\u5728\u5375\u5de2\u764c<\/strong>\u4e2d\uff0c\u5982\u679c\u7ed3\u5408\u5bf9\u6fc0\u6d3b\u7684\u6811\u7a81\u72b6\u7ec6\u80de<\/strong>\u7684\u5206\u6790\uff0c\u9ad8\u6c34\u5e73\u7684CALR mRNA<\/strong>\u8868\u8fbe\u5bf9\u60a3\u8005\u7684\u751f\u5b58\u8868\u73b0\u51fa\u6709\u5229<\/strong>\u7684\u5f71\u54cd\u3002\u76f8\u53cd\uff0cCD47\u7684\u9ad8\u8868\u8fbe<\/strong>\u5bf9\u591a\u79cd\u4e0d\u540c\u80bf\u7624\u7684\u9884\u540e\u6709\u8d1f\u9762<\/strong>\u5f71\u54cd\u3002<\/p>\n

\u9aa8\u9ad3\u589e\u751f\u6027\u80bf\u7624<\/strong>\u4e2d\u5df2\u63cf\u8ff0\u4e86CALR\u57fa\u56e0\u7684\u7a81\u53d8<\/span>\uff0c\u5bfc\u81f4\u76f8\u5e94\u57fa\u56e0\u4ea7\u7269\u7684\u9519\u8bef\u5b9a\u4f4d<\/strong>\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u7a81\u53d8\u5bf9\u80bf\u7624\u514d\u75ab\u76d1\u89c6\u7684\u786e\u5207\u5f71\u54cd\u4ecd\u4e0d\u6e05\u695a\u3002<\/p>\n

\u65e0\u8bba\u5982\u4f55\uff0c\u4e34\u5e8a\u6570\u636e\u8bc1\u5b9e\u4e86CALR\u66b4\u9732\u9014\u5f84\u5bf9\u80bf\u7624\u751f\u7269\u5b66\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 13.2<\/span> \u4f5c\u4e3a\u6811\u7a81\u72b6\u7ec6\u80de\u6297\u539f\u6444\u53d6\u4fe1\u53f7\u7684\u9499\u7f51\u86cb\u767d\u3002\u5728\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1(ICD)\u8fc7\u7a0b\u4e2d\uff0c\u5185\u8d28\u7f51(ER)\u5e94\u6fc0\u4ecb\u5bfc\u7684\u5185\u8d28\u7f51\u4f34\u4fa3\u9499\u7f51\u86cb\u767d(CALR)\u66b4\u9732(\u6216\u91ca\u653e)\u5230\u8d28\u819c\u8868\u9762\uff0c\u662f\u6811\u7a81\u72b6\u7ec6\u80de\u6297\u539f\u6444\u53d6\u7684\u4fe1\u53f7\u3002CALR\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u4e0a\u8868\u8fbe\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53\u76f8\u5173\u86cb\u767d1(LRP1)\u53d7\u4f53\u7684\u7ed3\u5408\u6709\u52a9\u4e8e\u80bf\u7624\u76f8\u5173\u6297\u539f\u5411DC\u7684\u8f6c\u79fb\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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HMGB1<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9ad8\u8fc1\u79fb\u7387\u65cf\u86cb\u767d1(HMGB1<\/strong>)\u662f\u542b\u91cf\u6700\u4e30\u5bcc\u7684\u975e\u7ec4\u86cb\u767d\u67d3\u8272\u8d28\u7ed3\u5408\u86cb\u767d<\/strong>\u3002<\/p>\n

HMGB1\u901a\u5e38\u53ea\u5728\u7ec6\u80de\u6838\u5185\u88ab\u53d1\u73b0<\/span>\uff0c\u4f46\u53ef\u4ee5\u5728\u6291\u5236\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\u540e\u8f6c\u79fb\u5230\u7ec6\u80de\u8d28\u4e2d\u3002<\/p>\n

\u6b64\u5916\uff0cHMGB1\u901a\u5e38\u662f\u4ece\u574f\u6b7b\u6027\u51cb\u4ea1<\/strong>\u6216\u7ee7\u53d1\u6027\u574f\u6b7b<\/strong>\u7684\u7ec6\u80de\u4e2d\u91ca\u653e<\/strong>\u51fa\u6765\u7684\u3002\u5728\u5bf9\u84bd\u73af\u7c7b\u836f\u7269\u7684\u53cd\u5e94\u4e2d\uff0c\u5728RIPK3\u6216MLKL\u88ab\u6572\u9664<\/strong>\u7684\u5c0f\u9f20\u764c\u7ec6\u80de\u4e2d\uff0c\u4e0e\u5176\u5177\u6709\u574f\u6b7b\u80fd\u529b\u7684\u5bf9\u7167\u7ec6\u80de\u76f8\u6bd4\uff0c\u5176\u5bf9\u84bd\u73af\u7c7b\u836f\u7269\u7684\u53cd\u5e94\u91ca\u653e\u51fa\u66f4\u5c11\u7684HMGB1\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c0f\u9f20\u4f53\u5185\u79fb\u690d\u7624\u5b9e\u9a8c\u8868\u660e\uff0c\u5316\u7597\u540eHMGB1\u5728\u4f53\u5185\u4f1a\u4ece\u764c\u7ec6\u80de\u4e2d\u91ca\u653e\u51fa\u6765\u3002HMGB1\u88abRNA\u5e72\u6270\u8017\u5c3d\u7684\u764c\u7ec6\u80de\u5728\u4f53\u5185\u4e0d\u80fd\u89e6\u53d1ICD\uff0c\u5e76\u5bf9\u5316\u7597\u4ea7\u751f\u8010\u836f\u6027\u3002\u540c\u6837\uff0c\u6ce8\u5c04\u6297HMGB1\u6297\u4f53\u53ef\u5728\u4f53\u5185\u6d88\u9664ICD\u8bf1\u5bfc\u7684\u5316\u7597\u5f15\u8d77\u7684\u6297\u764c\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u751f\u957f\u3002\u8fd9\u4e9b\u7ed3\u679c\u652f\u6301\u4e86\u7ec6\u80de\u5916HMGB1\u5728\u80bf\u7624\u514d\u75ab\u5b66\u4e2d\u4f5c\u4e3a\u4e00\u79cdDAMP\uff08\u5371\u9669\u76f8\u5173\u5206\u5b50\u6a21\u5f0f\uff09\u5206\u5b50<\/span>\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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HMGB1<\/strong>\u4e00\u65e6\u51fa\u73b0\u5728\u7ec6\u80de\u5916\u7a7a\u95f4\uff0c\u5c31\u53ef\u4ee5\u4e0e\u6838\u9178<\/strong>\u548c\u7ec6\u83cc\u591a\u7cd6<\/strong>\u7b49\u591a\u79cd\u9644\u52a0\u56e0\u5b50\u76f8\u4e92\u4f5c\u7528\u3002HMGB1\u8fd8\u4e0e\u51e0\u79cd\u53d7\u4f53\u7ed3\u5408\uff0c\u5305\u62ectoll\u6837\u53d7\u4f534(TLR4)<\/strong>\uff0cTLR4<\/strong>\u5728\u5305\u62ec\u6811\u7a81\u72b6\u7ec6\u80de\u5728\u5185\u7684\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u523a\u6fc0\u7ec6\u80de\u6210\u719f\u548c\u6297\u539f\u5448\u9012(Fig12.4<\/span>)\u3002\u4ece\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u6572\u9664TLR4\u6216\u5176\u9002\u914d\u86cb\u767dMYD88\uff0c\u53ef\u6d88\u9664ICD\u7684\u611f\u77e5\uff0c\u5e76\u6d88\u9664\u84bd\u73af\u7c7b\u6216\u5965\u6c99\u5229\u94c2\u5bf9\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u4f5c\u7528\u3002\u8fd9\u4e00\u7f3a\u9677\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de\u6297\u539f\u63d0\u5448\u51cf\u5c11\u6709\u5173<\/span>\uff0c\u53ef\u901a\u8fc7\u6eb6\u9176\u4f53\u6291\u5236\u5242\u6c2f\u55b9<\/strong>\u7684\u6cbb\u7597\u90e8\u5206\u6062\u590d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u5728\u4eba\u7c7b\u4e73\u817a\u764c<\/strong>\u4e2d\uff0cHMGB1\u8868\u8fbe\u964d\u4f4e\u4e0e\u75be\u75c5\u8fdb\u5c55\u548c\u80bf\u7624\u589e\u5927\u6709\u5173\u3002HMGB1\u8868\u8fbe\u964d\u4f4e\u662f\u4e73\u817a\u764c\u7684\u4e00\u4e2a\u8d1f\u9762\u9884\u540e\u7279\u5f81<\/span>\uff0c\u5b83\u4e0eCD8+<\/sup>\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u3001FOXP3+<\/sup>\u8c03\u8282\u6027T\u7ec6\u80de\u548cCD68+<\/sup>\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u7fa4\u5728\u80bf\u7624\u5185\u7684\u6d78\u6da6\u6709\u5173\u3002<\/p>\n

\u6b64\u5916\uff0c\u81f3\u5c11\u6709\u4e24\u79cd\u7c7b\u578b\u7684\u764c\u75c7TLR4\u529f\u80fd\u7b49\u4f4d\u57fa\u56e0\u7684\u7f3a\u5931\u4f1a\u5f71\u54cd\u60a3\u8005\u7684\u9884\u540e\uff0c\u5373(1)\u4e73\u817a\u764c\u548c(2)\u5206\u522b\u4ee5\u84bd\u73af\u7c7b\u836f\u7269\u548c\u5965\u6c99\u5229\u94c2\u4e3a\u57fa\u7840\u7684\u8f85\u52a9\u5316\u7597\u6cbb\u7597\u7684\u7ed3\u76f4\u80a0\u764c\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86HMGB1\/TLR4\u7684\u76f8\u4e92\u4f5c\u7528<\/strong>\u5bf9\u764c\u75c7\u60a3\u8005\u751f\u5b58\u548c\u9884\u540e\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u5728HMGB1\u9634\u6027\u764c\u75c7\u7684\u60c5\u51b5\u4e0b\uff0c\u4eba\u5de5\u4f9b\u5e94\u5408\u6210\u7684TLR4\u914d\u4f53<\/strong>\u6811\u7a81\u72b6\u4eb2\u548c\u7d20\uff0c\u53ef\u4ee5\u5f25\u8865HMGB1\u7684\u7f3a\u9677\uff0c\u5e76\u6062\u590d\u5c0f\u9f20\u6a21\u578b\u5316\u7597\u5f15\u8d77\u7684\u6297\u764c\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u79cd\u65b9\u6cd5\u662f\u5426\u4e5f\u9002\u7528\u4e8e\u643a\u5e26HMGB1\u9634\u6027\u80bf\u7624\u7684\u764c\u75c7\u60a3\u8005\u8fd8\u6709\u5f85\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig 12.4<\/span> HMGB1\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u63d0\u5448\u6297\u539f\u3002\u9ad8\u8fc1\u79fb\u7387\u65cf\u86cb\u767d1(HMGB1)\u901a\u5e38\u9690\u85cf\u5728\u7ec6\u80de\u6838\u4e2d\uff0c\u5728\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u540e\u671f\u9636\u6bb5\u88ab\u91ca\u653e\u51fa\u6765\uff0c\u4f5c\u4e3a\u5bf9\u84bd\u73af\u7c7b\u836f\u7269\u5316\u7597\u6216\u7535\u79bb\u8f90\u5c04\u7b49\u6cbb\u7597\u7684\u53cd\u5e94\u3002\u7ec6\u80de\u5916HMGB1\u4f5c\u4e3a\u6811\u7a81\u72b6\u7ec6\u80de(DC)\u4e0aTLR4\u7684\u914d\u4f53\uff0c\u89e6\u53d1MYD88\u4f9d\u8d56\u4fe1\u53f7\uff0c\u523a\u6fc0DC\u6210\u719f\u5e76\u5411\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de(CTL)\u5448\u9012\u6297\u539f\u3002TLR4,Toll\u6837\u53d7\u4f534\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n

\n
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I\u578b\u5e72\u6270\u7d20\u4e0e\u8d8b\u5316\u56e0\u5b50<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4f5c\u4e3a\u5bf9\u5316\u7597\u836f\u7269\u7684\u53cd\u5e94\uff0c\u80bf\u7624\u7ec6\u80de\u4f1a\u91ca\u653e\u5305\u62ecDNA\u548c\u53cc\u94feRNA\u5728\u5185\u7684\u6838\u9178\uff0c\u8fd9\u53ef\u80fd\u4f1a\u6fc0\u6d3b\u7ec6\u80de\u5185\u6216\u7ec6\u80de\u5916\u5bf9\u8fd9\u7c7b\u5f02\u5e38\u5206\u5b50\u7684\u4f20\u611f\u5668\u3002\u8fd9\u79cd\u6838\u9178\u4f20\u611f\u5668<\/strong>\u7684\u4e00\u4e2a\u4f8b\u5b50\u662fToll\u6837\u53d7\u4f533(TLR3)<\/strong>\uff0c\u4f46\u662f\u5305\u62ecGAS\/STING \u9014\u5f84<\/strong>\u5728\u5185\u7684\u5176\u4ed6\u4f20\u611f\u5668\u4e5f\u53ef\u80fd\u53c2\u4e0e\u5176\u4e2d\u3002\u8fd9\u4e9b\u523a\u6fc0\u7c7b\u4f3c\u4e8e\u7531\u75c5\u6bd2\u611f\u67d3\u5f15\u8d77\u7684\u523a\u6fc0\uff0c\u56e0\u6b64\u53ef\u4ee5\u88ab\u79f0\u4e3a\u201c\u75c5\u6bd2\u62df\u6001<\/strong>\u201d\uff0c\u764c\u7ec6\u80de\u8f6c\u5f55\u6fc0\u6d3b\u4e00\u4e2a\u6216\u51e0\u4e2a I \u578b\u5e72\u6270\u7d20\u57fa\u56e0\uff0c\u5206\u6ccc\u76f8\u5e94\u7684\u57fa\u56e0\u4ea7\u7269\uff0c\u7136\u540e\u523a\u6fc0\u5b83\u4eec\u7684I\u578b\u5e72\u6270\u7d20\u53d7\u4f53(IFNAR)\uff0c\u8bf1\u5bfc\u591a\u65b9\u9762\u7684I\u578b\u5e72\u6270\u7d20\u53cd\u5e94\uff0c\u5305\u62ec\u6fc0\u6d3b\u591a\u79cd\u6297\u75c5\u6bd2\u548c\u514d\u75ab\u523a\u6fc0\u57fa\u56e0\u4ea7\u7269 \uff08Fig12.5<\/span>\uff09\u3002<\/p>\n

\u4e00\u79cd\u5178\u578b\u7684\u6297\u75c5\u6bd2\u57fa\u56e0\u4ea7\u7269\u662f\u7c98\u6db2\u75c5\u6bd2\u6297\u60271 (MX1<\/strong>)\uff0c\u4e00\u4e2a\u4f17\u6240\u5468\u77e5\u7684\u514d\u75ab\u523a\u6fc0\u57fa\u56e0\u4ea7\u7269\u662fC-X-C\u57fa\u5e8f\u8d8b\u5316\u56e0\u5b50\u914d\u4f5310(CXCL10<\/strong>)\uff0c\u5b83\u4f5c\u7528\u4e8eC-X-C\u57fa\u5e8f\u8d8b\u5316\u56e0\u5b50\u53d7\u4f533(CXCR3<\/strong>)\uff0c\u5438\u5f15T\u6dcb\u5df4\u7ec6\u80de\u8fdb\u5165\u80bf\u7624\u5e8a\u3002\u7f3a\u4e4f TLR3\u3001IFNAR \u6216 CXCL10 \u7684\u764c\u7ec6\u80de\u5728\u5316\u7597\u540e\u65e0\u6cd5\u5f15\u53d1\u6297\u764c\u514d\u75ab\u53cd\u5e94\uff0c\u56e0\u6b64\u5bf9\u6cbb\u7597\u65e0\u6548\u3002<\/span>\u5c40\u90e8\u6ce8\u5c04\u91cd\u7ec4 I \u578b\u5e72\u6270\u7d20\u548c CXCL10 \u53ef\u4ee5\u5f25\u8865\u8fd9\u4e00\u7f3a\u9677\uff0c\u8fd9\u5f3a\u8c03\u4e86 I \u578b\u5e72\u6270\u7d20\u53cd\u5e94\u5bf9\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u6cbb\u7597\u7ed3\u679c\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u81f3\u5c11\u5728\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u4e0a\u8ff0\u9014\u5f84\u4f3c\u4e4e\u4e0e\u6cbb\u7597\u76f8\u5173\u3002\u5316\u7597\u53ef\u8bf1\u5bfcMX1\u5728\u4f53\u5185\u8868\u8fbe\u3002\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50 1 (STAT1<\/strong>) \u78f7\u9178\u5316\u6216\u4f4e MX1<\/strong> \u8868\u8fbe\u7684\u7f3a\u4e4f\u8868\u660e\u901a\u8fc7 IFNAR \u4fe1\u53f7\u4f20\u5bfc\u7684\u7f3a\u5931\u6784\u6210\u4e0d\u826f\u9884\u540e\u7279\u5f81\uff0c\u7279\u522b\u662f\u5728\u57fa\u4e8e\u84bd\u73af\u7c7b\u7684\u8f85\u52a9\u5316\u7597\u7684\u60c5\u51b5\u4e0b\u3002<\/p>\n

\u636e\u62a5\u9053\uff0c\u5f71\u54cdTLR3<\/strong>\u529f\u80fd\u7684\u591a\u6001\u6027\u4f1a\u5f71\u54cd\u4e73\u817a\u764c\u60a3\u8005\u7684\u547d\u8fd0\u3002\u8fd9\u4e9b\u7ed3\u679c\u5fc5\u987b\u5728\u8d8a\u6765\u8d8a\u591a\u7684\u4e34\u5e8a\u8bc1\u636e\u7684\u80cc\u666f\u4e0b\u89e3\u91ca\uff0c\u8fd8\u6709\u8bc1\u636e\u8868\u660e\uff0cI\u578b\u5e72\u6270\u7d20\u53ef\u4ee5\u6ce8\u5c04\u5230\u60a3\u8005\u4f53\u5185\uff0c\u4ee5\u523a\u6fc0\u80be\u764c\u548c\u6162\u6027\u7c92\u7ec6\u80de\u767d\u8840\u75c5(CML)\u60a3\u8005\u7684\u6297\u764c\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 12.5<\/span> I\u578b\u5e72\u6270\u7d20\u4f9d\u8d56\u6027\u8d8b\u5316\u56e0\u5b50\u7684\u91ca\u653e\u4f1a\u89e6\u53d1T\u7ec6\u80de\u542f\u52a8\u3002\u4f5c\u4e3a\u5bf9\u6a21\u62df\u75c5\u6bd2\u611f\u67d3\u7684\u5316\u7597\u836f\u7269\u7684\u53cd\u5e94\uff0c\u6b7b\u4ea1\u7ec6\u80de\u4e2d\u4f1a\u91ca\u653e\u6838\u9178\uff0c\u6210\u4e3aToll\u6837\u53d7\u4f533(TLR3)\u7b49\u5206\u5b50\u7684\u4f20\u611f\u5668\uff0c\u5e76\u5728\u8f6c\u5f55\u4e0a\u6fc0\u6d3b\u4e00\u4e2a\u6216\u51e0\u4e2a1\u578b\u5e72\u6270\u7d20\u57fa\u56e0\u3002\u4e00\u65e6\u5206\u6ccc\uff0c\u5e72\u6270\u7d20\u523a\u6fc0I\u578b\u5e72\u6270\u7d20\u53d7\u4f53\u8bf1\u5bfc\u591a\u65b9\u9762\u7684I\u578b\u5e72\u6270\u7d20\u53cd\u5e94\uff0c\u5305\u62ec\u4ea7\u751fC-X-C\u57fa\u5e8f\u8d8b\u5316\u56e0\u5b50\u914d\u4f5310(CXCL10)\uff0c\u4f5c\u7528\u4e8eC-X-C\u57fa\u5e8f\u8d8b\u5316\u56e0\u5b50\u53d7\u4f533(CXCR3)\uff0c\u5438\u5f15T\u6dcb\u5df4\u7ec6\u80de\u8fdb\u5165\u80bf\u7624\u5e8a\uff0c\u6700\u7ec8\u5bfc\u81f4\u03b3\u03b4T\u7ec6\u80de\u4ecb\u5bfc\u7684\u03b1\u03b2T\u7ec6\u80de\u542f\u52a8\u3002CXCR3\uff0cCXC\u8d8b\u5316\u56e0\u5b50\u53d7\u4f533\uff1bIFNAR1\uff1b\u5e72\u6270\u7d20\u03b1\/\u03b2\u53d7\u4f53\u4e9a\u57fa1\uff1bIL\uff0c\u767d\u7ec6\u80de\u4ecb\u7d20\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n

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\u7ed3\u675f\u8bed\u548c\u5c55\u671b<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7efc\u4e0a\u6240\u8ff0\uff0c\u6709\u591a\u79cd DAMP<\/strong>\uff08\u5982 ANXA1\u3001ATP\u3001CALR\u3001HMGB1 \u548c I \u578b\u5e72\u6270\u7d20\uff09\u5728\u514d\u75ab\u539f\u6027\u5316\u5b66\u7597\u6cd5\u4e2d\u5145\u5f53\u8f85\u52a9\u4fe1\u53f7\uff08Fig12.6<\/span>\uff09\u3002<\/p>\n

\u8981\u6ce8\u610f\u5730\u662f\uff0c\u8fd9\u4e9bDAMP\u5206\u5b50\u5e76\u4e0d\u4ee5\u5197\u4f59\u7684\u65b9\u5f0f\u8d77\u4f5c\u7528<\/span>(\u5728\u5197\u4f59\u7684\u60c5\u51b5\u4e0b\uff0c\u5b83\u4eec\u5c06\u80fd\u591f\u76f8\u4e92\u66ff\u4ee3)\uff0c\u800c\u662f\u4ee5\u975e\u5197\u4f59\u7684\u65b9\u5f0f\u8d77\u4f5c\u7528\uff0c\u8fd9\u610f\u5473\u7740\u4ece\u7cfb\u7edf\u4e2d\u79fb\u9664\u4e00\u4e2a\u5355\u4e00\u7684DAMP(\u6216\u5176\u53d7\u4f53)\u5c31\u8db3\u4ee5\u7834\u574f\u514d\u75ab\u539f\u6027\u5316\u7597\u5f15\u8d77\u7684\u6297\u764c\u514d\u75ab\u76d1\u89c6\u3002<\/p>\n

\u4ea7\u751f\u8fd9\u4e2a\u95ee\u9898\u7684\u4e00\u79cd\u53ef\u80fd\u6027\u662f\u5047\u8bbe\u6bcf\u4e2a DAMP \u90fd\u5fc5\u987b\u9075\u5faa\u8bbe\u5b9a\u597d\u7684\u65f6\u7a7a\u5e8f\u5217\uff0c\u5f88\u53ef\u80fd\u662f\u5728\u4e00\u4e2a\u72ed\u7a84\u7684\u5f3a\u5ea6\u8303\u56f4\u5185\uff0c\u9075\u5faa\u201c\u94a5\u5319-\u9501\u539f\u5219\u201d\u3002\u5373\u53ea\u6709\u5f53 DAMP \u4ee5\u6b63\u786e\u7684\u987a\u5e8f\u3001\u4ee5\u6b63\u786e\u7684\u5f3a\u5ea6\u8868\u8fbe<\/strong>\u65f6\uff0c\u5b83\u4eec\u624d\u80fd\u6210\u4e3a\u6253\u5f00\u901a\u5e38\u963b\u6b62\u514d\u75ab\u53cd\u5e94\u7684\u4fdd\u9669\u5e93\u7684\u201c\u94a5\u5319\u201d\u3002<\/p>\n

\u636e\u63a8\u6d4b\uff0c\u8be5\u7cfb\u7edf\u7684\u8fd9\u79cd\u7279\u6b8a\u60c5\u51b5\u53ef\u80fd\u662f\u4e3a\u4e86\u964d\u4f4e\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u4e0d\u5fc5\u8981\u7684\u81ea\u8eab\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u7684\u53ef\u80fd\u6027<\/span>\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u8fd9\u610f\u5473\u7740\u7531\u4e8e\u4e00\u4e2a\u5355\u4e00\u7684DAMP\u53d7\u4f53\u7684\u7a81\u53d8(\u53ef\u80fd\u662f\u7531\u514d\u75ab\u9009\u62e9\u9a71\u52a8\u7684)\u6216\u6291\u5236\uff0c\u6216\u8005\u76f4\u63a5\u6291\u5236\u4e00\u4e2a\u5355\u4e00\u7684DAMP\u8db3\u4ee5\u7834\u574f\u6297\u764c\u514d\u75ab\u76d1\u89c6<\/span>\uff0c\u5e76\u51cf\u5c11\u764c\u75c7\u60a3\u8005\u5728\u5316\u7597\u65f6\u63a7\u5236\u75be\u75c5\u7684\u673a\u4f1a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5b9e\u9645\u4e0a\uff0c\u8fd9\u662f\u901a\u8fc7\u6784\u5efa\u751f\u7269\u4f20\u611f\u5668\u7ec6\u80de\u7cfb\u6765\u5b9e\u73b0\u7684\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7cfb\u8868\u8fbe\u4e0e\u7eff\u8272\u8367\u5149\u86cb\u767d(GFP)\u6216\u5176\u884d\u751f\u7269\u878d\u5408\u7684ANXA1\u3001CALR\u6216HMGB1\u7684\u8367\u5149\u86cb\u767d\u3002\u901a\u8fc7\u5c06GFP\u7f6e\u4e8eMX1\u542f\u52a8\u5b50\u7684\u63a7\u5236\u4e0b\uff0c\u53ef\u4ee5\u786e\u5b9aI\u578b\u5e72\u6270\u7d20\u53cd\u5e94\u7684\u6fc0\u6d3b\u3002\u56e0\u6b64\uff0c\u4f7f\u7528\u8fd9\u79cd\u751f\u7269\u4f20\u611f\u5668\uff0c\u53ef\u4ee5\u9009\u62e9\u523a\u6fc0ICD\u5404\u4e2a\u65b9\u9762\u7684\u6297\u764c\u836f\u7269\u3002\u6211\u4eec\u5df2\u7ecf\u6210\u529f\u5730\u4f7f\u7528\u8fd9\u4e00\u65b9\u6cd5\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u9274\u5b9a\u51fa\u4e86\u5728\u4f53\u5185\u80fd\u591f\u6709\u6548\u523a\u6fc0\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684ICD\u8bf1\u5bfc\u5242\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 12.6<\/span> \u6cbb\u7597\u8bf1\u5bfc\u7684\u514d\u75ab\u76d1\u89c6\u4e2d\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u3002\u764c\u7ec6\u80de\u5728\u963f\u9709\u7d20\u6216\u5965\u6c99\u5229\u94c2\u7b49\u5316\u7597\u836f\u6cbb\u7597\u540e\u53d1\u751f\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1(ICD)\uff0c\u8868\u73b0\u6216\u91ca\u653e\u67d0\u4e9b\u5371\u9669\u76f8\u5173\u7684\u5206\u5b50\u6a21\u5f0f(DAMP)\uff0c\u5982\u9499\u7f51\u86cb\u767d(CALR)\u3001ATP\u3001I\u578b\u5e72\u6270\u7d20(IFN)\u3001\u9ad8\u8fc1\u79fb\u7387\u65cf\u86cb\u767d1(HMGB1)\u548c\u819c\u8054\u86cb\u767dA1(ANXA1)\u3002\u8fd9\u4e9b\u5206\u5b50\u4e0e\u9aa8\u9ad3\u6216\u6dcb\u5df4\u7ec6\u80de\u8868\u9762\u7684\u8bc6\u522b\u53d7\u4f53\u7684\u8fde\u63a5\u53ef\u4fc3\u8fdb\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u62db\u52df\u548c\u6fc0\u6d3b\uff0c\u5b83\u4eec\u56de\u5230\u5782\u6b7b\u7684\u764c\u7ec6\u80de\uff0c\u968f\u540e\u5bf9\u80bf\u7624\u6297\u539f\u6444\u53d6\uff0c\u6700\u540e\u8fdb\u884c\u5448\u9012(\u5728\u6811\u7a81\u72b6\u7ec6\u80de\u6210\u719f\u65f6)\u3002\u514d\u75ab\u523a\u6fc0\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u6700\u7ec8\u5bfc\u81f4\u6d89\u53ca\u03b1\u03b2\u548c\u03b3\u03b4T\u7ec6\u80de\u7684\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u7684\u5f00\u59cb\uff0c\u4ece\u800c\u91cd\u5efa\u764c\u75c7\u514d\u75ab\u76d1\u89c6\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/section>\n
f<\/span>or Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | <\/span>Oliver Kepp, Jonathan Pol, Laurence Zitvogel, and Guido Kroemer<\/span><\/section>\n
\u7ffb\u8bd1 |   \u5f90\u66fc\u65af \u6f58\u541b\u541b \u7ae0\u9707<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u90d1\u68a6\u6021<\/span><\/span><\/section>\n
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\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

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OncoLab\u5b66\u672f\u661f\u7403<\/strong>\u73b0\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9<\/strong>\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

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\u7528\u4e8eOncoLab\u8bfb\u8005\u4ea4\u6d41\u4e92\u52a9\u6c38\u4e45\u514d\u8d39
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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