{"id":2708,"date":"2022-10-07T23:55:05","date_gmt":"2022-10-07T15:55:05","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2022\/10\/07\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac13%e7%ab%a0%ef%bc%9a%e8%82%bf%e7%98%a4%e7%89%b9%e5%bc%82%e6%80%a7%e5%9f%ba%e5%9b%a0%e6%94%b9%e5%8f%98%e5%8f%af%e6%88%90%e4%b8%ba%e5%85%8d\/"},"modified":"2022-10-07T23:55:05","modified_gmt":"2022-10-07T15:55:05","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac13%e7%ab%a0%ef%bc%9a%e8%82%bf%e7%98%a4%e7%89%b9%e5%bc%82%e6%80%a7%e5%9f%ba%e5%9b%a0%e6%94%b9%e5%8f%98%e5%8f%af%e6%88%90%e4%b8%ba%e5%85%8d","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2022\/10\/07\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac13%e7%ab%a0%ef%bc%9a%e8%82%bf%e7%98%a4%e7%89%b9%e5%bc%82%e6%80%a7%e5%9f%ba%e5%9b%a0%e6%94%b9%e5%8f%98%e5%8f%af%e6%88%90%e4%b8%ba%e5%85%8d\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c13\u7ae0\uff1a\u80bf\u7624\u7279\u5f02\u6027\u57fa\u56e0\u6539\u53d8\u53ef\u6210\u4e3a\u514d\u75ab\u6cbb\u7597\u9776\u70b9\uff08\u4e0b\uff09"},"content":{"rendered":"
\n
\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

13.5 <\/strong>\u4f5c\u4e3a\u80bf\u7624\u75ab\u82d7\u9776\u70b9\u7684\u80bf\u7624\u7279\u5f02\u6027\u57fa\u56e0\u6539\u53d8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e0e\u514d\u75ab\u666e\u904d\u6fc0\u6d3b\u7684\u7597\u6cd5(\u5982\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6216\u5e72\u6270\u7d20)\u4e0d\u540c\uff0c\u63a5\u79cd\u75ab\u82d7\u53ef\u8bf1\u5bfc\u9488\u5bf9\u4e0d\u540c\u80bf\u7624\u8868\u4f4d\u7684\u66f4\u7279\u5f02\u6027\u7684\u5b9a\u5411\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

Table 13.1\u5217\u4e3e\u4e86<\/span><\/span>\u76ee\u524d\u80bf\u7624\u75ab\u82d7\u5f00\u53d1\u7684\u4e00\u4e9b\u65b9\u5f0f\uff1a\u5305\u62ec\u4e3b\u52a8\u63a5\u79cd\uff0c\u5373\u63a5\u79cd\u4e3b\u52a8\u514d\u75ab\u7ec6\u80de\uff0c\u5982\u6811\u7a81\u72b6\u7ec6\u80de\u3001CAR T\u7ec6\u80de\u6216\u65b0\u6297\u539f\u8868\u4f4d\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u6216\u4f7f\u7528\u591a\u80bd\u8fdb\u884c\u88ab\u52a8\u514d\u75ab\uff0c\u6216\u4f7f\u7528\u9488\u5bf9\u4e00\u4e2a\u6216\u591a\u4e2a\u80bf\u7624\u7279\u5f02\u6027\u8868\u4f4d\u7684RNA\/DNA(Table 13.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 13.1<\/span> \u75ab\u82d7\u5f00\u53d1\u65b9\u5f0f<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e3b\u52a8\u514d\u75ab\u6cbb\u7597\u4f7f\u7528\u60a3\u8005\u6765\u6e90\u7684\u7ec6\u80de\uff0c\u5728\u4f53\u5916\u6fc0\u6d3b\u548c\u6269\u589e\u5b83\u4eec\uff0c\u5e76\u5c06\u5b83\u4eec\u56de\u8f93\u5230\u60a3\u8005\u4f53\u5185\u3002\u8fd9\u79cd\u4e2a\u6027\u5316\u7684\u514d\u75ab\u7597\u6cd5\u9700\u8981\u975e\u5e38\u82db\u523b\u548c\u590d\u6742\u7684\u6280\u672f\u652f\u6491\uff0c\u4f7f\u5f97\u5927\u578bIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5546\u4e1a\u5316\u548c\u5b9e\u65bd\u66f4\u52a0\u590d\u6742\u3002<\/p>\n

\u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u662f\u4e00\u79cd\u5df2\u7ecf\u88ab\u6279\u51c6\u7684\u5b89\u5168\u7684\u4e14\u80fd\u4ea7\u751f\u7597\u6548\u7684\u75ab\u82d7\uff0c\u4f8b\u5982\u5bf9\u9ed1\u8272\u7d20\u7624\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u524d\u5217\u817a\u764c\u5747\u6709\u7597\u6548\u3002<\/p>\n

\u7b80\u800c\u8a00\u4e4b\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5c31\u662f\u5148\u4ece\u60a3\u8005\u8eab\u4e0a\u63d0\u53d6\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u524d\u4f53\u7ec6\u80de\u5e76\u8fdb\u884c\u4f53\u5916\u6269\u589e\u3002\u518d\u4f7f\u7528\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u3001CD40L\u6216TLR\u6fc0\u52a8\u5242\u4f7f\u5355\u6838\u7ec6\u80de\u6210\u719f\u3002\u7136\u540e\uff0c\u6210\u719f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u901a\u8fc7\u63a5\u89e6\u591a\u80bd\u3001\u86cb\u767d\u8d28\u3001\u5df2\u77e5\u7684\u80bf\u7624\u65b0\u6297\u539f\u6216\u60a3\u8005\u7279\u5b9a\u7684\u80bf\u7624\u88c2\u89e3\u7269\u6765\u88c5\u8f7d\u80bf\u7624\u6297\u539f\u3002<\/p>\n

\u8fd9\u4e9b\u6fc0\u6d3b\u7684\u3001\u6210\u719f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u88ab\u91cd\u65b0\u6ce8\u5165\u60a3\u8005\u4f53\u5185\uff0c\u968f\u540e\u53ef\u4ee5\u901a\u8fc7\u5411T\u7ec6\u80de\u9012\u5448\u6297\u539f\u4ee5\u53ca\u7ef4\u6301B\u7ec6\u80de\u8bb0\u5fc6\u529f\u80fd\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7684\u6fc0\u6d3b\u6765\u8bf1\u5bfc\u7279\u5f02\u6027\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u7597\u6cd5\u4ec5\u5728\u4e00\u9879\u8f6c\u79fb\u6027\u53bb\u52bf\u8010\u53d7\u524d\u5217\u817a\u764c\u7684\u524d\u77bb\u6027III\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fc7\u7ee7\u8f6c\u79fb\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u662f\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u7684\u53e6\u4e00\u79cd\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\uff0c\u5176\u5df2\u88ab\u8bc1\u660e\u5728\u514d\u75ab\u8c03\u8282\u6cbb\u7597\u901a\u5e38\u6548\u679c\u4e0d\u597d\u7684\u5b9e\u4f53\u80bf\u7624\u4e2d\u4e5f\u80fd\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\uff0c\u5982\u7ed3\u76f4\u80a0\u764c\u548c\u80c6\u7ba1\u764c\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u4e8c\u4ee3\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u88ab\u7528\u6765\u63ed\u793a\u53ef\u80fd\u4f5c\u4e3a\u65b0\u6297\u539f\u8868\u4f4d\u53d1\u6325\u4f5c\u7528\u7684\u975e\u540c\u4e49\u7a81\u53d8\u3002\u4ece\u60a3\u8005\u4e0a\u63d0\u53d6\u6811\u7a81\u72b6\u7ec6\u80de\uff0c\u6811\u7a81\u72b6\u7ec6\u80de\u53ef\u4ee5\u5c06\u8fd9\u4e9b\u65b0\u8868\u4f4d\u5448\u9012\u7ed9\u4ece\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5206\u79bb\u51fa\u6765\u7684T\u7ec6\u80de(\u80bf\u7624\u6d78\u6da6\u6027T\u6dcb\u5df4\u7ec6\u80de)\u3002\u7136\u540e\u5c06\u5bf9\u5448\u9012\u7684\u65b0\u6297\u539f\u6709\u7279\u5f02\u6027\u53cd\u5e94\u7684T\u7ec6\u80de\u5728\u4f53\u5916\u6269\u589e\uff0c\u518d\u6ce8\u5165\u60a3\u8005\u4f53\u5185\u3002<\/p>\n

\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53ef\u4ee5\u542f\u52a8\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u8fd9\u4f7f\u5f97\u8fd9\u4e9b\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u6301\u7eed\u5b58\u5728\u5e76\u63a7\u5236\u80bf\u7624\u7684\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u79cd\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u662f\u5e94\u7528\u5177\u6709\u5d4c\u5408\u6297\u539f\u53d7\u4f53(CAR)\u7684T\u7ec6\u80de\u3002<\/p>\n

\u4e3a\u4e86\u4ea7\u751f\u6297\u539f\u7279\u5f02\u7684CAR T\u7ec6\u80de\u7c7b\u578b\uff0c\u9700\u8981\u4ece\u60a3\u8005\u8eab\u4e0a\u83b7\u53d6\u5916\u5468T\u7ec6\u80de\u3002\u63a5\u4e0b\u6765\uff0c\u901a\u8fc7\u75c5\u6bd2\u6216\u975e\u75c5\u6bd2\u65b9\u6cd5\u5c06\u6240\u9700\u7684\u6297\u539f\u7279\u5f02\u6027CAR\u5f15\u5165T\u7ec6\u80de\uff0c\u4ece\u800c\u4ea7\u751f\u5177\u6709\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53d7\u4f53\u7684T\u7ec6\u80de\u3002CAR T\u7ec6\u80de\u5728\u4f53\u5916\u6269\u589e\uff0c\u5e76\u91cd\u65b0\u6ce8\u5165\u60a3\u8005\u4f53\u5185\u3002<\/p>\n

CAR T\u7ec6\u80de\u662f\u53ef\u4ee5\u9776\u5411\u8868\u8fbe\u6297\u539f\u7684\u7ec6\u80de\uff0c\u4ee5\u4e0d\u4f9d\u8d56\u4e8eMHC\u7684\u65b9\u5f0f\u589e\u5f3aT\u7ec6\u80de\u6548\u5e94\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u5355\u500d\u578b\u53ef\u80fd\u4e0d\u4f1a\u5f71\u54cdCAR T\u7ec6\u80de\u6cbb\u7597\u7684\u7597\u6548\u3002<\/p>\n

\u76ee\u524d\u5b9e\u4f53\u764c\u75c7\u4e2dCAR T\u7597\u6cd5\u7684\u6f5c\u5728\u9776\u70b9\u6709\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532(HER2)\u3001\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u3001\u95f4\u76ae\u86cb\u767d\u548c\u764c\u80da\u6297\u539f(CEA)\u7b49\u65b0\u6297\u539f\u3002<\/p>\n

\u9664\u4e86\u5bf9\u6076\u6027\u8840\u6db2\u75c5\u5df2\u7ecf\u6709\u5b9e\u8d28\u6027\u7684\u4e34\u5e8a\u7597\u6548\u5916\uff0c\u7b2c\u4e00\u6279\u75c5\u4f8b\u62a5\u544a\u4e5f\u663e\u793a\u51fa\u5bf9\u5b9e\u4f53\u764c\u6709\u7597\u6548\uff0c\u76ee\u524d\u6709\u51e0\u9879\u7814\u7a76\u6b63\u5728\u62db\u52df\u7814\u7a76\u5bf9\u8c61\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9664\u4e86\u4f7f\u7528\u4f53\u5916\u57f9\u517b\u60a3\u8005\u7279\u5b9a\u7ec6\u80de\u7684\u6cbb\u7597\u65b9\u6cd5\u5916\uff0c\u8fd8\u8bbe\u8ba1\u4e86\u51e0\u79cd\u57fa\u4e8e\u591a\u80bd\u6216RNA\/DNA\u7684\u75ab\u82d7\u63a5\u79cd\u65b9\u6cd5\uff0c\u4ee5\u901a\u8fc7\u589e\u52a0(\u65b0)\u6297\u539f\u7684\u53ef\u7528\u6027\u6765\u589e\u5f3a\u5bbf\u4e3b\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u5355\u4e00\u65b0\u8868\u4f4d\u75ab\u82d7\u4ec5\u9488\u5bf9\u7279\u5b9a\u80bf\u7624\u7684\u4e00\u79cd\u7279\u5b9a\u6297\u539f\u3002\u56e0\u6b64\u8be5\u9776\u8868\u4f4d\u5fc5\u987b\u5728\u5927\u591a\u6570\u764c\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u4ee5\u786e\u4fdd\u542f\u52a8\u7684T\u7ec6\u80de\u53cd\u5e94\u662f\u6709\u6548\u7684\u3002<\/p>\n

\u76ee\u524d\u5df2\u7ecf\u8fdb\u884c\u4e86\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\uff0c\u4f8b\u5982\u9488\u5bf9HER2\u8fc7\u8868\u8fbe\u4e73\u817a\u764c\u7684HER2\u7279\u5f02\u6027\u75ab\u82d7\u63a5\u79cd\u6216\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u7684gp100\u75ab\u82d7\u3002<\/p>\n

\u7136\u800c\uff0c\u5355\u8868\u4f4d\u5bfc\u5411\u7684\u514d\u75ab\u53cd\u5e94\u5bfc\u81f4\u6297\u539f\u9633\u6027\u764c\u7ec6\u80de\u7684\u9009\u62e9\u538b\u529b\u5927\uff0c\u5e76\u4e3a\u9634\u6027\u7ec6\u80de\u63d0\u4f9b\u751f\u5b58\u4f18\u52bf\uff0c\u9020\u6210\u4e86\u6f5c\u5728\u7684\u514d\u75ab\u9003\u9038\u3002<\/p>\n

\u6b64\u5916\uff0c\u591a\u80bd\u56e0HLA\u5355\u500d\u578b\u7684\u4e0d\u540c\u800c\u4e0eMHC\u7684\u4eb2\u548c\u529b\u4e0d\u540c\uff0c\u8fd9\u9650\u5236\u4e86\u67d0\u4e9b\u591a\u80bd\u75ab\u82d7\u5bf9\u8868\u8fbe\u7279\u5b9a\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u5355\u500d\u578b\u7684\u60a3\u8005\u7684\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e0e\u5355\u8868\u4f4d\u75ab\u82d7\u76f8\u6bd4\uff0c\u4f7f\u7528\u80bf\u7624\u7684\u51e0\u4e2a\u9891\u7e41\u51fa\u73b0\u7684\u8868\u4f4d\u7684\u591a\u8868\u4f4d\u75ab\u82d7\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u4ea7\u751f\u66f4\u5e7f\u6cdb\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u66f4\u6709\u6548\u5730\u9632\u6b62\u514d\u75ab\u9003\u9038\u3002<\/p>\n

\u5728\u75ab\u82d7\u63a5\u79cd\u4e2d\u542b\u6709\u4e00\u7ec4\u9884\u5b9a\u4e49\u7684\u8868\u4f4d\uff0c\u8fd9\u4e9b\u8868\u4f4d\u5df2\u88ab\u9274\u5b9a\u4e3a\u5728\u67d0\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u9891\u7e41\u8868\u8fbe\u3002\u7136\u800c\u5982\u524d\u6240\u8ff0\uff0c\u5c3d\u7ba1\u7279\u5b9a\u80bf\u7624\u7684\u7ec4\u7ec7\u5b66\u548c\u4f4d\u7f6e\u53ef\u80fd\u5177\u6709\u53ef\u6bd4\u6027\uff0c\u4f46\u7279\u5b9a\u60a3\u8005\u7684\u7279\u5f02\u6027\u6297\u539f\u7279\u5f81\u662f\u975e\u5e38\u72ec\u7279\u7684\u3002<\/p>\n

\u7a81\u53d8\u7279\u5f02\u6027\u75ab\u82d7\u63a5\u79cd\u63d0\u4f9b\u4e86\u4e00\u79cd\u66f4\u52a0\u4e2a\u6027\u5316\u7684\u75ab\u82d7\u63a5\u79cd\u65b9\u6cd5\uff1a\u53ef\u4ee5\u5728\u7279\u5b9a\u7684\u60a3\u8005\u4e2d\u8bc6\u522b\u51fa\u7279\u5b9a\u7684\u591a\u4e2a\u65b0\u8868\u4f4d\uff0c\u5e76\u4fc3\u8fdb\u4e2a\u6027\u5316\u75ab\u82d7\u7684\u5236\u9020\u3002<\/p>\n

\u8fd9\u4e9b\u65b0\u8868\u4f4d\u53ef\u4ee5\u901a\u8fc7\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u548c\u65b0\u6297\u539f\u9884\u6d4b\u6216\u76f4\u63a5\u901a\u8fc7\u8d28\u8c31\u4eea\u8bc6\u522b\u3002\u56e0\u6b64\uff0c\u80bf\u7624\u7684\u5f02\u8d28\u6027\u7684\u95ee\u9898\u5f97\u5230\u4e86\u66f4\u5145\u5206\u7684\u89e3\u51b3\uff0c\u4e5f\u66f4\u6709\u53ef\u80fd\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u56e0\u6b64\u8bf8\u5982\u7279\u5b9a\u6297\u539f\u6216\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u5355\u500d\u578b\u7684\u5b58\u5728\u7684\u9650\u5236\u51cf\u5c11\u4e86\u3002<\/p>\n

\u7136\u800c\uff0c\u5e76\u4e0d\u662f\u6240\u6709\u7684\u57fa\u56e0\u7a81\u53d8\u90fd\u4f1a\u5bfc\u81f4\u8f6c\u5f55\u86cb\u767d\u548c\u514d\u75ab\u539f\u6027\u8868\u4f4d\u7684\u4ea7\u751f\u3002\u53ea\u6709\u5927\u7ea620%-40%\u7684(\u65b0)\u6297\u539f\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u5e76\u5bfc\u81f4\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u4ea7\u751f\u3002<\/p>\n

\u56e0\u6b64\uff0c\u4e00\u4e2a\u5173\u952e\u7684\u95ee\u9898\u662f\u5982\u4f55\u4ee5\u4e2a\u6027\u5316\u7684\u65b9\u5f0f\u8bc6\u522b\u76f8\u5173\u7684\u514d\u75ab\u539f\u6027\u764c\u75c7\u7a81\u53d8\u5e76\u8fdb\u884c\u6cbb\u7597\u63a2\u7d22\u3002\u5728\u8fd9\u91cc\uff0c\u91ce\u751f\u578b\u591a\u80bd\u548c\u7a81\u53d8\u65b0\u6297\u539f\u4e4b\u95f4\u7684\u6570\u503c\u5dee\u5f02\u4ee5\u53caMHC I\u548c\u591a\u80bd\u76f8\u4e92\u4f5c\u7528\u7684\u6784\u8c61\u7a33\u5b9a\u6027\u5bf9\u4e8e\u5b9a\u4e49\u65b0\u6297\u539f\u7684\u514d\u75ab\u539f\u6027\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u76ee\u524d\uff0c\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u6d4b\u8bd5\u5404\u79cd\u65b0\u8868\u4f4d\u75ab\u82d7\u65b9\u6cd5\uff0c\u8981\u4e48\u662f\u5355\u4e00\u7597\u6cd5\uff0c\u8981\u4e48\u662f\u8054\u5408\u7597\u6cd5\u3002<\/p>\n

\u50cf\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5e94\u7528\u4e00\u6837\uff0c\u75ab\u82d7\u7597\u6cd5\u9700\u8981\u8ba8\u8bba\u7684\u4e00\u4e2a\u91cd\u8981\u95ee\u9898\u662f\u786e\u5b9a\u54ea\u4e9b\u60a3\u8005\u6700\u6709\u53ef\u80fd\u4ece\u8fd9\u4e9b\u7279\u5b9a\u7684\u65b9\u6cd5\u4e2d\u53d7\u76ca\u3002\u5728\u8fd9\u91cc\u5e94\u8be5\u8003\u8651\u5230\u75be\u75c5\u7684\u8303\u56f4\u3002<\/p>\n

\u63a5\u79cd\u75ab\u82d7\u867d\u7136\u4f1a\u4ea7\u751f\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u4f46\u5f88\u53ef\u80fd\u4e0d\u4f1a\u5bfc\u81f4\u80bf\u7624\u7f29\u5c0f\uff0c\u800c\u662f\u63a7\u5236\u73b0\u6709\u7684\u80bf\u7624\u5927\u5c0f\u3002\u56e0\u6b64\uff0c\u4ec5\u6709\u80bf\u7624\u5fae\u5c0f\u75c5\u7076\u6b8b\u7559\u7684\u60a3\u8005\u53ef\u80fd\u53d7\u76ca\u6700\u5927\u3002<\/p>\n

\u56e0\u6b64\uff0c\u4e25\u8c28\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u5bf9\u4e8e\u786e\u5b9a\u4ece\u75ab\u82d7\u7684\u6cbb\u7597\u65b9\u6cd5\u4e2d\u53d7\u76ca\u6700\u5927\u7684\u60a3\u8005\u7fa4\u4f53\u4e5f\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

13.6 \u4f5c\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u514d\u75ab\u53cd\u5e94\u9884\u6d4b\u751f\u7269\u6807\u8bb0\u7269\u7684\u80bf\u7624\u57fa\u56e0\u6539\u53d8<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n
\n
\n

\u9664\u4e86\u5728\u63a5\u53d7\u9776\u5411CTLA4\u548cPD1\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u9ad8\u5e94\u7b54\u7387\u5916\uff0c\u8fd8\u6709\u5f88\u5927\u4e00\u90e8\u5206\u60a3\u8005\u6ca1\u6709\u53cd\u5e94\u3002<\/p>\n

\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u51c6\u786e\u548c\u7cbe\u786e\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u6765\u5145\u5206\u9009\u62e9\u5e94\u7b54\u53ef\u80fd\u6027\u6700\u9ad8\u7684\u60a3\u8005(Table 13.2 <\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table 13.2 <\/span>\u80bf\u7624\u7684\u57fa\u56e0\u6539\u53d8\u53ef\u4f5c\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u7269\u6cbb\u7597\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e8b\u5b9e\u4e0a\uff0c\u66f4\u786e\u5207\u5730\u8bf4\uff0c\u603b\u7684\u7a81\u53d8\u8d1f\u8377\u800c\u4e0d\u662f\u7279\u5b9a\u53d8\u5316\u4e0e\u514d\u75ab\u5e94\u7b54\u548c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5e94\u7b54\u7684\u53ef\u80fd\u6027\u589e\u52a0\u76f8\u5173(Fig.13.4<\/span>)\u3002<\/p>\n

\u540c\u6837\uff0c\u4e0e\u7a81\u53d8\u9891\u7387\u8f83\u4f4e\u7684\u80bf\u7624(\u5982\u4e73\u817a\u764c)\u76f8\u6bd4\uff0c\u9ed1\u8272\u7d20\u7624\u6216\u80ba\u817a\u764c\u7b49\u7a81\u53d8\u8d1f\u8377\u9ad8\u7684\u764c\u75c7\u7c7b\u578b\u5bf9\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u66f4\u654f\u611f\u3002<\/p>\n

\u7531\u66b4\u9732\u4e8e\u9ad8\u81f4\u764c\u7269\u8d28\u5bfc\u81f4\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5982\u7d2b\u5916\u7ebf\u8f90\u5c04\u5f15\u8d77\u7684\u9ed1\u8272\u7d20\u7624\u6216\u5438\u70df\u8005\u7684\u80ba\u764c\uff0c\u6216\u75c5\u6bd2\u8bf1\u5bfc\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5982\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u5448\u73b0\u51fa\u7279\u522b\u9ad8\u7684\u7a81\u53d8\u8d1f\u8377\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u7a81\u53d8\u8d1f\u8377\u5728\u4e0d\u540c\u764c\u75c7\u4e4b\u95f4\u5dee\u5f02\u5f88\u5927\uff0c\u5c3d\u7ba1\u5176\u4ed6\u7279\u5f81\uff0c\u5982\u7ec4\u7ec7\u5b66\u3001\u4f4d\u7f6e\u548c\u9a71\u52a8\u7a81\u53d8\u7684\u56e0\u7d20\u90fd\u975e\u5e38\u76f8\u4f3c\u3002\u4e00\u4e9b\u7a81\u53d8\u8d1f\u8377\u76f8\u5f53\u4f4e\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u5982\u7ed3\u76f4\u80a0\u764c\u6216\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0c\u5b58\u5728\u67d0\u4e9b\u7279\u5b9a\u7684\u9057\u4f20\u4e9a\u578b\u5982\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\u65f6\uff0c\u53ef\u80fd\u4f1a\u6709\u51fa\u4e4e\u610f\u6599\u7684\u53cd\u5e94\u3002<\/p>\n

\u7136\u800c\uff0c\u4f53\u7ec6\u80de\u7a81\u53d8\u6570\u91cf\u4e2d\u4f4d\u6570\u8f83\u4f4e\u7684\u764c\u75c7\u7c7b\u578b\u4e5f\u8868\u73b0\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u548c\u6301\u4e45\u7684\u53cd\u5e94\uff0c\u5982\u80be\u7ec6\u80de\u764c\u3002\u4ed6\u4eec\u8ba4\u4e3a\uff0c\u9664\u4e86\u539f\u59cb\u7a81\u53d8\u6570\u91cf\u5916\uff0c\u7a81\u53d8\u7684\u514d\u75ab\u5b66\u8d28\u91cf\u53ef\u80fd\u4f1a\u5f71\u54cd\u764c\u75c7\u514d\u75ab\u76d1\u6d4b\u3002<\/p>\n

\u66f4\u51c6\u786e\u5730\u8bf4\uff0c\u7a81\u53d8\u8d1f\u8377\u4e0e\u7ed9\u5b9a\u80bf\u7624\u7684\u514d\u75ab\u539f\u6027\u76f8\u5173\uff0c\u56e0\u4e3a\u6bcf\u589e\u52a0\u4e00\u4e2a\u7a81\u53d8\uff0c\u5c31\u4f1a\u589e\u52a0\u4ea7\u751f\u76f8\u5173\u60a3\u8005\u7279\u5f02\u6027\u764c\u75c7\u65b0\u6297\u539f\u7684\u51e0\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig.13.4 <\/span>\u4e0d\u540c\u539f\u53d1\u80bf\u7624\u7c7b\u578b\u7684\u7a81\u53d8\u8d1f\u8377\uff1b\uff08LUSC\u80ba\u9cde\u72b6\u7ec6\u80de\u764c\u3001LUAD\u80ba\u817a\u764c\u3001BLCA\u8180\u80f1\u5c3f\u8def\u4e0a\u76ae\u764c\u3001hNSC\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001COAD\u7ed3\u80a0\u817a\u764c\u3001GBM\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001UCEC\u5b50\u5bab\u4f53\u5b50\u5bab\u5185\u819c\u764c\u3001KIRC\u80be\u900f\u660e\u7ec6\u80de\u764c\u3001\u5375\u5de2\u6d46\u6db2\u6027\u56ca\u817a\u764c\u3001BRCA\u4e73\u817a\u6d78\u6da6\u6027\u764c\u3001LAML\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff09<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e8b\u5b9e\u4e0a\uff0c\u5927\u91cf\u7684\u7a81\u53d8\u548c\u9ad8\u8d1f\u8377\u7684\u65b0\u6297\u539f\u4e0eCD8+\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684\u589e\u52a0\u548c\u9884\u540e\u7684\u6539\u5584\u6709\u5173\u3002<\/p>\n

\u6839\u636e\u4e0eMHC\u590d\u5408\u7269\u7684\u4eb2\u548c\u529b\u3001\u4e0e\u91ce\u751f\u578b\u591a\u80bd\u7684\u4e0d\u540c\u4ee5\u53ca\u80bf\u7624\u5185\u65b0\u6297\u539f\u7684\u5f02\u8d28\u6027\uff0c\u8fd9\u79cd\u65b0\u6297\u539f\u7684\u514d\u75ab\u539f\u6027\u53ef\u80fd\u4f1a\u6709\u6240\u4e0d\u540c\u3002<\/p>\n

\u5728\u9ed1\u8272\u7d20\u7624\u548c\u5176\u4ed6\u9ad8\u7a81\u53d8\u8d1f\u8377\u7684\u80bf\u7624\u4e2d\u53d1\u73b0\u7684\u5927\u591a\u6570\u7a81\u53d8\u90fd\u662f\u4e0e\u7ec6\u80de\u8f6c\u5316\u8fc7\u7a0b\u65e0\u5173\u7684\u201c\u4f34\u968f\u7a81\u53d8\u201d\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u764c\u75c7\u4e2d\u7edd\u5927\u591a\u6570\u6f5c\u5728\u7684\u65b0\u8868\u4f4d\u90fd\u662f\u60a3\u8005\u7279\u6709\u7684\u3002<\/p>\n

\u5728\u5bf9CTLA4\u6291\u5236\u5242\u6709\u53cd\u5e94\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u53d1\u73b0\u4e86\u4e0e\u8bb8\u591a\u75c5\u6bd2\u548c\u7ec6\u83cc\u6297\u539f\u540c\u6e90\u7684\u65b0\u8868\u4f4d\u7279\u5b9a\u65b0\u6297\u539f\u7279\u5f81\u3002\u8fd9\u79cd\u7279\u6b8a\u7684\u65b0\u6297\u539f\u6807\u8bb0\u662f\u5426\u5728\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u4e5f\u5177\u6709\u9884\u6d4b\u6f5c\u529b\uff0c\u4ee5\u53ca\u80fd\u5426\u5b9a\u4e49\u5177\u6709\u9ad8\u7a81\u53d8\u8d1f\u8377\u7684\u80bf\u7624\u7684\u6700\u7ec8\u622a\u65ad\u503c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6b64\u5916\uff0c\u7a81\u53d8\u8f7d\u91cf\u7684\u4e22\u5931\u4e0e\u5bf9CTLA4\u6291\u5236\u7684\u53cd\u5e94\u7684\u53ef\u80fd\u6027\u76f8\u5173\u3002\u8fd9\u91cc\u7a81\u53d8\u8f7d\u91cf\u7684\u4e22\u5931\u4e0e\u9ed1\u8272\u7d20\u7624\u7684\u8fdb\u5c55\u6709\u5173\uff0c\u53ef\u80fd\u662f\u514d\u75ab\u9003\u9038\u7684\u539f\u56e0\u4e4b\u4e00\uff0c\u56e0\u4e3a\u53d1\u73b0\u4e86\u7a81\u53d8\u8f7d\u91cf\u7684\u4e22\u5931\u4e0e\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u4e0b\u8c03\u7684\u76f8\u5173\u6027\u3002\u6709\u8da3\u7684\u662f\uff0c\u4f4e\u7a81\u53d8\u8f7d\u91cf\u7684\u4e22\u5931\u548c\u9ad8\u7a81\u53d8\u8d1f\u8f7d\u7684\u6548\u5e94\u5bf9\u4e34\u5e8a\u53cd\u5e94\u5177\u6709\u975e\u5197\u4f59\u6548\u5e94\uff0c\u8868\u660e\u51e0\u4e2a\u9884\u6d4b\u6807\u8bb0\u7269\u7684\u7ec4\u5408\u53ef\u80fd\u53ef\u4ee5\u63d0\u4f9b\u66f4\u51c6\u786e\u7684\u53cd\u5e94\u9884\u6d4b\u3002\u4e00\u4e9b\u622a\u65ad\u7f16\u7801\u5e72\u6270\u7d20\u53d7\u4f53\u76f8\u5173\u7684JAK1\u548cJAK2\u7684\u57fa\u56e0\u6539\u53d8\u88ab\u8bc1\u660e\u4e0e\u5bf9\u6297PD1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u83b7\u5f97\u6027\u62b5\u6297\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

13.7 \u4e2a\u6027\u5316\u514d\u75ab\u6cbb\u7597\uff1a\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u7684\u8054\u5408<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n
\n
\n

\u867d\u7136\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u5df2\u7ecf\u89c2\u5bdf\u5230\u4ee4\u4eba\u9f13\u821e\u7684\u5e94\u7b54\u7387\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u4ecd\u7136\u4e0d\u80fd\u4ece\u76ee\u524d\u53ef\u7528\u7684\u6cbb\u7597\u4e2d\u957f\u671f\u53d7\u76ca\u3002\u8fd9\u53ef\u80fd\u662f\u7531\u4e8e\u9664\u4e86\u5bbf\u4e3b\u7279\u5f02\u6027\u56e0\u7d20\u5916\uff0c\u80bf\u7624\u540c\u65f6\u5177\u6709\u51e0\u4e2a\u6d3b\u8dc3\u7684\u514d\u75ab\u9003\u9038\u56e0\u7d20\u3002<\/p>\n

\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u76f8\u4e92\u7ed3\u5408\u6216\u4e0e\u5176\u4ed6\u5df2\u5efa\u7acb\u7684\u6cbb\u7597\u65b9\u6848\u76f8\u7ed3\u5408\uff0c\u53ef\u4ee5\u901a\u8fc7\u6539\u5584\u764c\u75c7-\u514d\u75ab\u5faa\u73af\u7684\u4e0d\u540c\u6b65\u9aa4\u6765\u589e\u5f3a\u5bbf\u4e3b\u548c\u764c\u75c7\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7f3a\u4e4f\u53ef\u7528\u7684\u6297\u539f\u53ef\u4ee5\u901a\u8fc7\u63a5\u79cd\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u6765\u514b\u670d\u3002<\/p>\n

\u76ee\u524d\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u75ab\u82d7\u63a5\u79cd\u4e0e\u68c0\u67e5\u70b9\u6291\u5236\u5177\u6709\u534f\u540c\u6548\u5e94\uff0c\u5c3d\u7ba1CTLA4\u6291\u5236\u548cgp100\u75ab\u82d7\u8054\u5408\u7684\u4e34\u5e8a\u7814\u7a76\u5e76\u672a\u663e\u793a\u51fa\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u989d\u5916\u7597\u6548\u3002\u7136\u800c\uff0c\u6700\u8fd1\u5173\u4e8e\u80bd\u75ab\u82d7\u7597\u6cd5\u7684\u53d1\u73b0\uff0c\u5305\u62ec\u5efa\u7acb\u7a81\u53d8\u4f53\u7279\u5f02\u6027\u75ab\u82d7\uff0c\u88ab\u8ba4\u4e3a\u53ef\u80fd\u6210\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u4e00\u4e2a\u66f4\u597d\u7684\u642d\u914d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6240\u8c13\u7684\u975e\u5c40\u90e8\u6027\u6548\u5e94\u4e3b\u5f20\u653e\u5c04\u6cbb\u7597\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5408\u7406\u7ed3\u5408\u3002<\/p>\n

\u4ece\u7406\u8bba\u4e0a\u8bb2\uff0c\u653e\u5c04\u6cbb\u7597\u9996\u5148\u901a\u8fc7\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u8bf1\u5bfc\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u6765\u589e\u52a0\u6297\u539f\u7684\u53ef\u83b7\u5f97\u6027\u3002\u6b64\u5916\uff0c\u653e\u7597\u5bf9\u708e\u6027\u5fae\u73af\u5883\u6709\u591a\u4e2a\u5c40\u90e8\u5f71\u54cd\uff0c\u5e76\u8bf1\u5bfc\u80bf\u7624\u4e0e\u6297\u539f\u63d0\u5448\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u7684\u6d78\u6da6\u3002<\/p>\n

\u56e0\u6b64\uff0c\u75ab\u82d7\u63a5\u79cd\u548c\u653e\u5c04\u6cbb\u7597\u4ee5\u53ca\u5176\u4ed6\u5bfc\u81f4\u6297\u539f\u5448\u9012\u589e\u52a0\u7684\u6cbb\u7597\u65b9\u6cd5\u7684\u8054\u5408\u53ef\u4ee5\u514b\u670d\u6297\u539f\u5448\u9012\u4e0d\u8db3\u7684\u95ee\u9898\uff0c\u800c\u6297\u539f\u5448\u9012\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u8054\u5408\u4f7f\u7528\u53ef\u80fd\u5177\u6709\u534f\u540c\u4f5c\u7528\u3002<\/p>\n

\u7136\u800c\uff0c\u76ee\u524d\u4eba\u4eec\u5bf9\u5982\u4f55\u8bc6\u522b\u6297\u539f\u63d0\u5448\u4e0d\u8db3\u7684\u60a3\u8005\u77e5\u4e4b\u751a\u5c11\uff0c\u56e0\u4e3a\u8fd8\u6ca1\u6709\u53ef\u9760\u7684\u6807\u8bb0\u7269\u6765\u91cf\u5316\u6297\u539f\u63d0\u5448\u7684\u6709\u6548\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5982\u4e0a\u6240\u8ff0\uff0c\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u53d7\u5230\u9ad8\u5ea6\u8c03\u63a7\uff0c\u56e0\u4e3a\u51e0\u4e2aTCR\u8f85\u52a9\u53d7\u4f53\u901a\u8fc7\u589e\u5f3a\u6216\u6291\u5236\u4fe1\u53f7\u6765\u63a7\u5236\u7531\u6b64\u4ea7\u751f\u7684T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n

PD1\u548cCTLA4\u90fd\u662f\u6291\u5236T\u7ec6\u80de\u53cd\u5e94\u7684\u9014\u5f84\uff0c\u5b9e\u9645\u4e0a\u51cf\u5c11\u4e86T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002\u540c\u6837\uff0c\u8fd9\u79cd\u6291\u5236\u5bfc\u81f4\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u201c\u91ca\u653e\u201d\u3002<\/p>\n

\u7136\u800c\uff0cPD1\u68c0\u67e5\u70b9\u6291\u5236\u4f1a\u5bfc\u81f4\u5176\u4ed6\u514d\u75ab\u6291\u5236\u6027\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u901a\u8def\u7684\u4e0a\u8c03\uff0c\u5982TIM3\u3002\u56e0\u6b64\uff0c\u4e24\u79cd\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u53ef\u80fd\u4f1a\u514b\u670d\u8fd9\u79cd\u514d\u75ab\u9003\u9038\u673a\u5236\u3002<\/p>\n

\u5c3d\u7ba1\u8003\u8651\u5230\u8f83\u9ad8\u7684\u6bd2\u526f\u4f5c\u7528\uff0cCTLA4\u548cPD1\u963b\u6ede\u5242\u8054\u5408\u4f7f\u7528\u4ecd\u6bd4\u5355\u72ec\u4f7f\u7528\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728\u4e34\u5e8a\u4e0a\u66f4\u6709\u6548\u3002<\/p>\n

\u6b64\u5916\uff0cCTLA4\u6cbb\u7597\u88ab\u8bc1\u660e\u589e\u52a0\u4e86\u80bf\u7624\u4e2d\u5b58\u5728\u7684TCR\u514b\u9686\u6027\uff0c\u4ece\u800c\u63d0\u9ad8\u4e86\u5bf9PD1\u5b9a\u5411\u6cbb\u7597\u7684\u5e94\u7b54\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u76ee\u524d\u6709\u51e0\u9879\u7814\u7a76\u6b63\u5728\u7814\u7a76\u9776\u5411TIM3\u3001LAG3\u3001OX40\u7b49\u7684\u7b2c\u4e8c\u4ee3\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e0e\u7b2c\u4e00\u4ee3\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8054\u5408\u4f7f\u7528\u7684\u4e34\u5e8a\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9664\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5916\uff0c\u8fdb\u4e00\u6b65\u7684\u7ec4\u5408\u65e8\u5728\u589e\u52a0\u80bf\u7624\u5185T\u7ec6\u80de\u7684\u5bc6\u5ea6\u3002<\/p>\n

PI3K\u548cMEK\u901a\u8def\u88ab\u8bc1\u660e\u5f71\u54cd\u80bf\u7624\u7ec4\u7ec7\u5185T\u7ec6\u80de\u7684\u5bc6\u5ea6\u3002\u56e0\u6b64\uff0c\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e2d\u6dfb\u52a0MEK\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u53ef\u80fd\u4f1a\u589e\u52a0\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\u7684\u5bc6\u5ea6\uff0c\u5c06\u201c\u51b7\u201d\u80bf\u7624\u8f6c\u53d8\u4e3a\u201c\u70ed\u201d\u80bf\u7624\uff0c\u4ece\u800c\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u6cbb\u7597\u66f4\u654f\u611f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u4e2a\u6709\u524d\u666f\u7684\u7ec4\u5408\u662f\u5728\u6807\u51c6\u5316\u7597\u65b9\u6848\u4e2d\u6dfb\u52a0\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u56e0\u4e3a\u8bb8\u591a\u6807\u51c6\u5316\u7597\u5df2\u88ab\u8bc1\u660e\u5177\u6709\u514d\u75ab\u8c03\u8282\u529f\u80fd\u3002<\/p>\n

\u4ee5\u94c2\u4e3a\u57fa\u7840\u7684\u6807\u51c6\u5316\u7597\u548cPD1\u6291\u5236\u5242\u7684\u7ec4\u5408\u663e\u8457\u63d0\u9ad8\u4e86\u6709\u6548\u7387\u548c\u751f\u5b58\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6700\u540e\uff0c\u4e3a\u4e86\u4ea7\u751f\u6301\u4e45\u7684\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u8fd8\u5fc5\u987b\u8003\u8651\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u3002\u4eba\u4eec\u65e9\u5c31\u77e5\u9053\u5de8\u566c\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u4ee5\u4e00\u79cd\u4e34\u5e8a\u76f8\u5173\u7684\u65b9\u5f0f\u8c03\u8282T\u7ec6\u80de\u7684\u6d3b\u52a8\u3002<\/p>\n

\u6700\u8fd1\uff0c\u6709\u7814\u7a76\u8868\u660e\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\u53ef\u4ee5\u5bfc\u81f4\u975e\u514d\u75ab\u539f\u6027\u80bf\u7624\u4e2d\u7684\u6dcb\u5df4\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u53cd\u5e94\u589e\u5f3a\u3002\u76ee\u524d\uff0c\u5229\u7528\u8fd9\u4e9b\u8c03\u63a7\u8f74\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u6b63\u8fc5\u901f\u4ece\u5355\u5242\u7597\u6cd5\u5411\u8054\u5408\u7597\u6cd5\u8f6c\u53d8\uff0c\u4ee5\u89e3\u51b3\u60a3\u8005\u514d\u75ab\u7cfb\u7edf\u548c\u7ed9\u5b9a\u764c\u75c7\u4e4b\u95f4\u7684\u7279\u5b9a\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u7684\u7ed3\u5408\u80af\u5b9a\u4f1a\u4ea7\u751f\u53e6\u4e00\u5c42\u590d\u6742\u6027\uff0c\u8fd9\u5fc5\u987b\u901a\u8fc7\u4e34\u5e8a\u524d\u7814\u7a76\u6765\u66f4\u597d\u5730\u4e86\u89e3\u4ea7\u751f\u6f5c\u5728\u590d\u6742\u6027\u7684\u751f\u7269\u5b66\u539f\u7406\uff0c\u4ee5\u53ca\u53d1\u73b0\u76f8\u5e94\u7684\u7684\u751f\u7269\u6807\u8bb0\u7269\u6765\u89e3\u51b3\u3002<\/p>\n

\u5728\u8fd9\u91cc\uff0c\u6f5c\u5728\u7684\u9884\u6d4b\u7b97\u6cd5\u5fc5\u987b\u7ed3\u5408\u80bf\u7624\u672c\u8eab\u7684\u51e0\u4e2a\u9057\u4f20\u7279\u6027\uff0c\u4ee5\u53ca\u7531\u7279\u5b9a\u5bbf\u4e3b\u548c\u80bf\u7624\u7684\u76f8\u4e92\u4f5c\u7528\u5f15\u8d77\u7684\u5bbf\u4e3b\u7279\u5f02\u6027\u56e0\u7d20\u548c\u52a8\u6001\u56e0\u7d20\u3002<\/p>\n

\u5728\u5bf9\u708e\u6027\u80bf\u7624\u5fae\u73af\u5883\u7684\u6df1\u5165\u4e86\u89e3\u4e2d\uff0c\u5fc5\u987b\u8bc4\u4f30\u548c\u8fdb\u4e00\u6b65\u5206\u6790\u80bf\u7624\u548c\u5bbf\u4e3b\u7684\u9057\u4f20\u7279\u5f81\uff0c\u4ee5\u5f00\u53d1\u9884\u6d4b\u6027\u751f\u7269\u6807\u8bb0\u7269\u4fe1\u53f7\u3002<\/p>\n

\u6211\u4eec\u5fc5\u987b\u76d1\u6d4b\u8fde\u7eed\u80bf\u7624\u6d3b\u68c0\u7684\u5373\u65f6\u6cbb\u7597\u6548\u679c\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u7406\u89e3\u53cd\u5e94\u673a\u5236\uff0c\u66f4\u91cd\u8981\u7684\u662f\u4e86\u89e3\u4e2a\u4f53\u60a3\u8005\u7684\u8010\u836f\u673a\u5236\u3002\u8fd9\u4e9b\u6570\u636e\u5bf9\u6211\u4eec\u7684\u9884\u6d4b\u7b97\u6cd5\u975e\u5e38\u91cd\u8981\u3002<\/p>\n

\u6700\u7ec8\uff0c\u6211\u4eec\u53ef\u4ee5\u8bbe\u60f3\u4e34\u5e8a\u8bd5\u9a8c\u7b56\u7565\uff0c\u6bcf\u4e2a\u60a3\u8005\u90fd\u63a5\u53d7\u4e0d\u540c\u7684\u836f\u7269\u7ec4\u5408\uff0c\u751a\u81f3\u53ef\u80fd\u6309\u987a\u5e8f\u6539\u53d8\u3002\u80bf\u7624\u6cbb\u7597\u6548\u679c\u7684\u5b9e\u65f6\u8bc4\u4f30\u5c06\u6709\u52a9\u4e8e\u4e0d\u65ad\u4fee\u6539\u4e2a\u522b\u60a3\u8005\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 |<\/span> Oncoimmunology: A Practical Guide <\/span><\/section>\n
for Cancer Immunotherapy<\/span><\/section>\n
\u4f5c\u8005 | Anna S. Berghoff, Jakob Nikolas Kather, and Dirk J\u00e4ger<\/span><\/span><\/section>\n
\u7ffb\u8bd1 |   \u9648\u8389\u8679 \u90d1\u68a6\u6021 \u9648\u6653\u610f<\/span><\/section>\n
\u7f16\u8f91\u6392\u7248 | \u8d75\u6db5<\/span><\/span><\/span><\/section>\n
\u521d\u5ba1 | \u4efb\u632f\u9633 \u5ed6\u5a9b<\/span><\/section>\n
\u7ec8\u5ba1 | \u8096\u5efa\u52c7 \u738b\u5764<\/span><\/section>\n
\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/section>\n

<\/section>\n


<\/p>\n

\u2589  \u5f3a\u70c8\u63a8\u8350<\/strong><\/strong><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u672c\u516c\u4f17\u53f7\u4e0a\u7684\u5f80\u671f\u6587\u7ae0\u540c\u6b65\u53d1\u5e03\u81f3\u5bf9\u5e94\u7f51\u7ad9OncoLab\u5b9e\u9a8c\u5ba4\u3002<\/p>\n

\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

\n
\n
\n
\n
\n

\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

\n
\n
\n
\n

OncoLab\u5b66\u672f\u661f\u7403<\/strong>\u73b0\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9<\/strong>\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/p>\n<\/section>\n

\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
\n
\n
<\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

<\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n

<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n

\u7528\u4e8eOncoLab\u8bfb\u8005\u4ea4\u6d41\u4e92\u52a9\u6c38\u4e45\u514d\u8d39
<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/section>\n
\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

13.5 \u4f5c\u4e3a\u80bf\u7624\u75ab\u82d7\u9776\u70b9\u7684\u80bf\u7624\u7279\u5f02\u6027\u57fa\u56e0\u6539\u53d8 \u4e0e\u514d\u75ab\u666e\u904d\u6fc0\u6d3b\u7684\u7597\u6cd5(\u5982\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6216\u5e72\u6270\u7d20)\u4e0d…<\/p>\n","protected":false},"author":1,"featured_media":2698,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2708"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=2708"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2708\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/2698"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=2708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=2708"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=2708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}