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\u63a5\u4e0b\u6765\uff0c\u901a\u8fc7\u7528MOG\u514d\u75ab\u8bf1\u5bfcC57BL\/6\u5c0f\u9f20\u7684\u5b9e\u9a8c\u6027\u81ea\u8eab\u514d\u75ab\u6027\u8111\u810a\u9ad3\u708e\uff08EAE\uff09\uff0c\u8bc4\u4f30\u4e86\u6297CTLA-4\u548c\u6297IL-6\u5bf9EAE\u4e25\u91cd\u7a0b\u5ea6\u548c\u53d1\u75c5\u7387\u7684\u5f71\u54cd\u3002\u4e0e\u63a5\u53d7IL-6\u963b\u65ad\u5242\u6216\u8054\u5408\u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u63a5\u53d7\u6297CTLA-4\u6cbb\u7597\u7684\u5c0f\u9f20EAE\u75c5\u7a0b\u52a0\u91cd\u3002EAE\u8bf1\u5bfc\u7684\u762b\u75ea\u5728\u6297CTLA-4\u7ec4\u66f4\u5e38\u89c1\uff08100%\uff09\uff0c\u800c\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\u670950%\uff0c\u5728\u6297IL-6\u5355\u836f\u6cbb\u7597\u7ec4\u4e2d\u4ec5\u670920%\u53d1\u751f\u762b\u75ea\u3002\u5728Balb\/c\u6a21\u578b\u4e2d\uff0c\u8fd9\u79cd\u6a21\u578b\u4ec5\u901a\u8fc7MOG\u514d\u75ab\u5c31\u80fd\u62b5\u6297EAE\u7684\u53d1\u5c55\uff0c\u63a5\u53d7\u6297CTLA-4\u6cbb\u7597\u7684\u514d\u75ab\u5c0f\u9f20\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6\u6bd4\u672a\u6cbb\u7597\u5c0f\u9f20\u9ad8\u51fa4\u500d\uff0c\u800c\u5728\u63a5\u53d7IL-6\u963b\u65ad\u5242\u6216\u8054\u5408\u6cbb\u7597\u7684\u514d\u75ab\u5c0f\u9f20\u4e2d\u6ca1\u6709\u89c2\u5bdf\u5230\u8fd9\u4e9b\u75c7\u72b6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u8bc4\u4f30IL-6\u963b\u65ad\u662f\u5426\u53ef\u4ee5\u5728\u4e0d\u589e\u52a0EAE\u4e25\u91cd\u7a0b\u5ea6\u7684\u60c5\u51b5\u4e0b\u6539\u5584\u764c\u75c7\u6cbb\u7597\uff0cEAE\u5728C57\/BL6\u5c0f\u9f20\u63a5\u79cdB16.BL6\u80bf\u7624\u540e\u4e09\u5929\u5185\u8bf1\u5bfc\u3002\u5355\u72ec\u4f7f\u7528\u6297CTLA-4\u6cbb\u7597\u7684\u5c0f\u9f20EAE\u75c7\u72b6\u52a0\u901f\uff0c\u800c\u8054\u5408\u6cbb\u7597\u5219\u4f7fEAE\u75c7\u72b6\u8f83\u8f7b\u4e14\u80bf\u7624\u63a7\u5236\u6539\u5584\u3002\u5f53\u6297CTLA-4\u66ff\u6362\u4e3a\u6297PD-1\u65f6\uff0c\u4e5f\u662f\u5982\u6b64\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u540e\uff0c\u7814\u7a76\u4eba\u5458\u56de\u987e\u4e86\u63a5\u53d7ICB\u6cbb\u7597\u7684\u60a3\u8005\u7684IL-6\u963b\u65ad\u6cbb\u7597\u7ecf\u9a8c\u3002\u572813,735\u4f8b\u63a5\u53d7ICB\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c31\u4f8b\u63a5\u53d7\u4e86IL-6\u963b\u65ad\u6cbb\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u5728IL-6\u963b\u65ad\u5f00\u59cb\u540e\uff0cirAEs\u51cf\u5c11\u4e8674%\u3002\u5728\u8fd9\u4e2a\u5c0f\u60a3\u8005\u4e9a\u7ec4\u4e2d\uff0c\u5728IL-6\u963b\u65ad\u524d\uff0c\u8fd9\u4e9b\u60a3\u8005\u5bf9ICB\u7684\u6700\u4f73\u5ba2\u89c2\u53cd\u5e94\u7387\u4e3a57.7%\uff0c\u5728\u6cbb\u7597\u540e\u4e3a65.4%\uff0c\u8868\u660e\u963b\u65adIL-6\u6d3b\u6027\u5bf9ICB\u6cbb\u7597\u6ca1\u6709\u8d1f\u9762\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u6b64\uff0c\u4eba\u7c7b\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u548c\u5c0f\u9f20\u673a\u5236\u7814\u7a76\u786e\u5b9aIL-6\u548c\u7c7b\u4f3cTh17\u7684\u7ec6\u80de\u662firAE\u53d1\u5c55\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\uff0c\u5e76\u8868\u660e\u5728ICB\u6cbb\u7597\u671f\u95f4\u9776\u5411IL-6\u4e0d\u4ec5\u53ef\u4ee5\u51cf\u8f7birAEs\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u800c\u4e14\u53ef\u4ee5\u6539\u5584\u80bf\u7624\u53cd\u5e94\u3002\u8fd9\u53ef\u80fd\u662f\u964d\u4f4eirAEs\u5e76\u63d0\u9ad8ICB\u6cbb\u7597\u53cd\u5e94\u7387\u7684\u4e00\u79cd\u7b56\u7565\uff0c\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u8fdb\u884c\u4e2d\u4ee5\u8bc4\u4f30\u8fd9\u79cd\u8054\u5408\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n


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\u672c\u5468\uff0c\u7b2c\u4e00\u5171\u540c\u4f5c\u8005Hailemichael\u3001Johnson\u3001Abdel-Wahab\u548c\u901a\u8baf\u4f5c\u8005Diab\u56de\u7b54\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u5de6\u5230\u53f3\uff1a\u7b2c\u4e00\u5171\u540c\u4f5c\u8005Hailemichael\u3001Johnson\u3001Abdel-Wahab\u548c\u901a\u8baf\u4f5c\u8005Diab<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u662f\u4ec0\u4e48\u4fc3\u4f7f\u60a8\u7814\u7a76\u8fd9\u4e2a\u95ee\u9898\uff1f<\/strong><\/p>\n

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\u76ee\u524d\uff0c\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u7684\u514d\u75ab\u6cbb\u7597\u662f\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7684\u6700\u4f73\u6cbb\u7597\u7b56\u7565\u3002\u7136\u800c\uff0cICI\u5355\u836f\u6cbb\u7597\u7684\u6301\u4e45\u7f13\u89e3\u7387\u4ecd\u7136\u5f88\u4f4e\uff0c\u56e0\u6b64\uff0c\u6211\u4eec\u9700\u8981ICI\u7684\u8054\u5408\u7b56\u7565\u6765\u514b\u670d\u6cbb\u7597\u8010\u836f\u6027\u3002\u7136\u800c\uff0c\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\u7684\u9ad8\u53d1\u751f\u7387\u9650\u5236\u4e86\u8054\u5408ICI\u7684\u4f7f\u7528\uff0c\u9996\u5148\uff0c\u8fd9\u53ef\u80fd\u589e\u52a0\u60a3\u8005\u7684\u75c7\u72b6\u8d1f\u62c5\uff0c\u5e76\u4e14\u53ef\u80fd\uff0c\u5c3d\u7ba1\u7f55\u89c1\uff0c\u4f46\u4f1a\u662f\u81f4\u547d\u7684\u3002\u6b64\u5916\uff0c\u8fd9\u4e9birAEs\u4e0e\u8f83\u9ad8\u7684\u6cbb\u7597\u4e2d\u6b62\u7387\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u63a5\u53d7\u8054\u5408ipilimumab\u548cnivolumab\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\uff0c\u8d85\u8fc750%\u7684\u60a3\u8005\u53ef\u80fd\u51fa\u73b0\u9ad8\u5ea6\u6bd2\u6027\uff0c\u8d85\u8fc7\u4e09\u5206\u4e4b\u4e00\u7684\u60a3\u8005\u9700\u8981\u505c\u6b62\u6cbb\u7597\uff08CheckMate 067\uff09\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u8ba4\u8bc6\u5230\u5728\u4e0d\u727a\u7272ICI\u6cbb\u7597\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b\u7684\u524d\u63d0\u4e0b\uff0c\u627e\u5230\u6cbb\u7597\u8fd9\u4e9b\u6bd2\u6027\u7684\u7b56\u7565\u662f\u4e00\u4e2a\u5173\u952e\u7684\u672a\u6ee1\u8db3\u9700\u6c42\u3002\u4f17\u6240\u5468\u77e5\uff0c\u767d\u7ec6\u80de\u4ecb\u7d20-6\uff08IL-6\uff09\/\u8f85\u52a9\u6027T\u7ec6\u80de17\uff08Th17\uff09\u901a\u8def\u5728\u51e0\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u8fd9\u4e9b\u75be\u75c5\u53ef\u80fd\u5728irAEs\u7684\u4e34\u5e8a\u8868\u73b0\u4e2d\u8868\u73b0\u51fa\u6765\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u8003\u8651\u7814\u7a76\u5176\u5728ICI\u76f8\u5173\u514d\u75ab\u6bd2\u6027\u4e2d\u7684\u4f5c\u7528\uff0c\u7136\u540e\u8bc4\u4f30IL-6\u963b\u65ad\u5982\u4f55\u5f71\u54cdICI\u80bf\u7624\u514d\u75ab\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u60a8\u8ba4\u4e3a\u6700\u4ee4\u4eba\u60ca\u8bb6\u7684\u53d1\u73b0\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n

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\u6211\u4eec\u91c7\u7528\u4e34\u5e8a\u3001\u4e34\u5e8a\u524d\u548c\u8f6c\u5316\u5206\u6790\u7684\u591a\u5b66\u79d1\u65b9\u6cd5\uff0c\u63ed\u793a\u4e86IL-6\/Th17\u9014\u5f84\u5728ICI\u76f8\u5173\u7684\u81ea\u8eab\u514d\u75ab\u6027\u548c\u8010\u836f\u6027\u4e2d\u7684\u4f5c\u7528\u3002\u7b80\u8a00\u4e4b\uff0c\u6211\u4eec\u7684\u6570\u636e\u663e\u793a\uff0c\u5728\u7ed3\u80a0\u708e\u4e0e\u975e\u708e\u75c7\u80a0\u7ec4\u7ec7\u4e2d\uff0cIL-6\u4ee5\u53ca\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u8d8b\u5316\u6027\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u8f83\u9ad8\uff0c\u8fd9\u8868\u660eIL-6\/Th17\u9014\u5f84\u53c2\u4e0e\u4e86irAEs\u7684\u53d1\u5c55\u3002\u6211\u4eec\u8fd8\u53d1\u73b0\uff0c\u5728\u7ed3\u80a0\u708e\u4e2d\u4e0a\u8c03\u7684\u57fa\u56e0\u5728\u5e94\u7b54\u80bf\u7624\u4e2d\u6ca1\u6709\u4e0a\u8c03\uff0c\u8fd9\u6697\u793a\u81ea\u8eab\u514d\u75ab\u548c\u80bf\u7624\u514d\u75ab\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u6f5c\u5728\u7684\u673a\u5236\u5dee\u5f02\u3002\u6b64\u5916\uff0c\u5728\u4f7f\u7528\u6297CTLA-4\u57fa\u7840\u6cbb\u7597\u4e0e\u6297PD-1\u5355\u836f\u6cbb\u7597\u7684\u60a3\u8005\u7684\u514d\u75ab\u76f8\u5173\u7ed3\u80a0\u708e\u4e2d\u8fdb\u884c\u6bd4\u8f83\u65f6\uff0c\u6211\u4eec\u53d1\u73b0CD4+ Th17\u7ec6\u80de\u5728\u6297CTLA-4\u7ec4\u4e2d\u66f4\u5bcc\u96c6\u3002\u6b64\u5916\uff0c\u8fd9\u4e24\u7ec4\u4e2d\u7684Th17\u8bb0\u5fc6\u7ec6\u80de\u90fd\u503e\u5411\u4e8e\u9ad8\u8868\u8fbeCTLA-4\u3002\u5728\u5b9e\u9a8c\u6027\u81ea\u8eab\u514d\u75ab\u6027\u8111\u810a\u9ad3\u708e\uff08EAE\uff09\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u6211\u4eec\u8bc1\u660e\u4e86ICI\u8bf1\u5bfc\u7684\u6bd2\u6027\u6076\u5316\u53ef\u4ee5\u901a\u8fc7\u6dfb\u52a0IL-6\u963b\u65ad\u5242\u6765\u7f13\u89e3\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u540c\u65f6\u63a5\u53d7\u4e86B16\u9ed1\u8272\u7d20\u7624\u6216CT26\u7ed3\u80a0\u764c\u80bf\u7624\u7684\u79fb\u690d\uff0c\u6211\u4eec\u53d1\u73b0\u6dfb\u52a0IL-6\u963b\u65ad\u5242\u589e\u5f3a\u4e86ICI\u8bf1\u5bfc\u7684\u80bf\u7624\u7f29\u5c0f\uff0c\u8fd9\u8868\u660eIL-6\u6291\u5236\u53ef\u4ee5\u540c\u65f6\u51cf\u8f7b\u81ea\u8eab\u514d\u75ab\u6027\u548c\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u3002\u7136\u540e\uff0c\u6211\u4eec\u901a\u8fc7\u56de\u987e\u6027\u5ba1\u67e5\u5fb7\u514b\u8428\u65af\u5dde\u5927\u5b66MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u63a5\u53d7Tocilizumab\u6216Sarilumab\uff08IL-6\u53d7\u4f53\u963b\u65ad\u6297\u4f53\uff09\u6cbb\u7597irAEs\u7684\u6240\u6709\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u9a8c\u8bc1\u4e86\u6211\u4eec\u7684\u53d1\u73b0\uff0c\u5e76\u53d1\u73b0ICI\u6cbb\u7597\u7684\u6700\u4f73\u603b\u4f53\u5e94\u7b54\u7387\u5728\u5f00\u59cbIL-6\u963b\u65ad\u524d\u540e\u6ca1\u6709\u5dee\u5f02\u3002\u603b\u7684\u6765\u8bf4\uff0c\u6211\u4eec\u7684\u6570\u636e\u8868\u660e\uff0cIL-6\u963b\u65ad\u53ef\u80fd\u662f\u4e00\u79cd\u6709\u6548\u7684\u9488\u5bf9irAEs\u7684\u9776\u5411\u6cbb\u7597\uff0c\u800c\u4e0d\u4f1a\u524a\u5f31\u80bf\u7624\u5bf9ICI\u6cbb\u7597\u7684\u53cd\u5e94\u3002\u7136\u800c\uff0c\u9700\u8981\u8fdb\u884c\u524d\u77bb\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u8fd9\u4e9b\u53d1\u73b0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u5de5\u4f5c\u4e4b\u5916\uff0c\u60a8\u6700\u8fd1\u4e86\u89e3\u5230\u7684\u6700\u9177\u7684\u4e8b\u60c5\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n

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\u4eba\u7c7b\u5728\u8ba1\u5212\uff0c\u800c\u4e0a\u5e1d\u5728\u7b11\uff01\u5feb\u4e50\u7684\u5dc5\u5cf0\u4e0d\u4ec5\u5728\u4e8e\u5b9e\u73b0\u81ea\u5df1\u7684\u76ee\u6807\uff0c\u66f4\u5728\u4e8e\u7ed9\u4e88\u4ed6\u4eba\u4ee5\u53ca\u5e2e\u52a9\u4ed6\u4eec\u5728\u751f\u6d3b\u4e2d\u5b9e\u73b0\u4ed6\u4eec\u7684\u76ee\u6807\uff01\uff01\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & Cancer Cell<\/span><\/span><\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
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\u516c\u4f17\u53f7\u53d1\u900120220525\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n

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\u2589  \u5f3a\u70c8\u63a8\u8350<\/strong><\/strong><\/p>\n

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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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