{"id":2928,"date":"2023-04-30T10:10:45","date_gmt":"2023-04-30T02:10:45","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/04\/30\/nature-20170524%ef%bc%9a%e8%82%bf%e7%98%a4%e7%9b%b8%e5%85%b3%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e9%80%9a%e8%bf%87%e8%a1%a8%e8%be%bepd-1%e6%8a%91%e5%88%b6%e5%85%b6%e5%90%9e%e5%99%ac%e5%8a%9f%e8%83%bd\/"},"modified":"2023-04-30T10:10:45","modified_gmt":"2023-04-30T02:10:45","slug":"nature-20170524%ef%bc%9a%e8%82%bf%e7%98%a4%e7%9b%b8%e5%85%b3%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e9%80%9a%e8%bf%87%e8%a1%a8%e8%be%bepd-1%e6%8a%91%e5%88%b6%e5%85%b6%e5%90%9e%e5%99%ac%e5%8a%9f%e8%83%bd","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/04\/30\/nature-20170524%ef%bc%9a%e8%82%bf%e7%98%a4%e7%9b%b8%e5%85%b3%e5%b7%a8%e5%99%ac%e7%bb%86%e8%83%9e%e9%80%9a%e8%bf%87%e8%a1%a8%e8%be%bepd-1%e6%8a%91%e5%88%b6%e5%85%b6%e5%90%9e%e5%99%ac%e5%8a%9f%e8%83%bd\/","title":{"rendered":"Nature. 20170524\uff1a\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u901a\u8fc7\u8868\u8fbePD-1\u6291\u5236\u5176\u541e\u566c\u529f\u80fd\u53ca\u6297\u80bf\u7624\u514d\u75ab"},"content":{"rendered":"
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\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\u5b58\u5728\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u901a\u5e38\u4e0e\u60a3\u8005\u7684\u9884\u540e\u8f83\u5dee\u76f8\u5173\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u7814\u7a76\u548c\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u963b\u65ad SIRP\u03b1 \u548c CD47 \u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u7684\u7597\u6cd5\u53ef\u4ee5\u8bf1\u5bfc TAMs \u541e\u566c\u80bf\u7624\u7ec6\u80de\uff0c\u4ece\u800c\u5e26\u6765\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Gordon \u7b49\u4eba\u5f00\u59cb\u63a2\u7d22\u53ef\u80fd\u8c03\u8282 TME \u4e2d\u5de8\u566c\u7ec6\u80de\u529f\u80fd\u7684\u5176\u4ed6\u673a\u5236\u3002\u9274\u4e8e\u5df2\u77e5\u5de8\u566c\u7ec6\u80de\u5728\u67d0\u4e9b\u611f\u67d3\u60c5\u51b5\u4e0b\u8868\u8fbe PD-1\uff0c\u8be5\u56e2\u961f\u60f3\u77e5\u9053\u80bf\u7624\u4e2d\u7684\u5de8\u566c\u7ec6\u80de\u662f\u5426\u4e5f\u5982\u6b64\u3002\u4ed6\u4eec\u4f7f\u7528\u4e86\u5c0f\u9f20\u7ed3\u80a0\u764c\u6a21\u578b\uff0c\u53d1\u73b0\u7ea6 50% \u7684\u80bf\u7624\u6d78\u6da6\u5de8\u566c\u7ec6\u80de\u8868\u8fbe\u8868\u9762 PD-1\uff0c\u4ece\u800c\u8bc1\u5b9e\u4e86\u4ed6\u4eec\u7684\u5047\u8bbe\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TAMs \u901a\u5e38\u5206\u4e3a\u708e\u75c7\u6027\u201cM1\u201d\u6216\u4fc3\u80bf\u7624\u201cM2\u201d\u5de8\u566c\u7ec6\u80de\u3002\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u6d41\u5f0f\u7ec6\u80de\u672f\u53d1\u73b0\uff0c\u5c3d\u7ba1\u5927\u591a\u6570 PD-1- TAMs \u7c7b\u4f3c\u4e8e M1 \u7ec6\u80de\uff0c\u4f46\u51e0\u4e4e\u6240\u6709 PD-1+ TAMs \u90fd\u8868\u8fbe M2 \u8868\u578b\uff0c\u8fd9\u8868\u660e PD-1 \u8868\u8fbe\u53ef\u80fd\u4e0e\u4fc3\u80bf\u7624\u7279\u5f81\u6709\u5173\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u6ce8\u610f\u5230\uff0cPD-1+ TAM \u7fa4\u4f53\u53ea\u662f\u5728\u80bf\u7624\u79fb\u690d\u540e\u4e24\u5468\u5f00\u59cb\u51fa\u73b0\uff0c\u5e76\u5728\u80bf\u7624\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u9010\u6e10\u79ef\u7d2f\u3002\u540c\u6837\uff0c\u5728\u4eba\u7c7b\u7ed3\u80a0\u764c\u6837\u672c\u4e2d\uff0c\u80bf\u7624\u5185 PD-1+ \u5de8\u566c\u7ec6\u80de\u7684\u9891\u7387\u968f\u75be\u75c5\u5206\u671f\u589e\u52a0\uff0c\u5e76\u4e0e M2 \u8868\u578b\u76f8\u5173\u3002PD-1+ TAMs \u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u589e\u52a0\u662f\u7531\u4e8e\u5faa\u73af\u9aa8\u9ad3\u6765\u6e90\u5de8\u566c\u7ec6\u80de\u5b9a\u4f4d\u4e8e\u708e\u75c7\u6027 TME\uff0c\u800c\u4e0d\u662f\u6765\u6e90\u4e8e\u9a7b\u7559\u514d\u75ab\u7ec6\u80de\u7684\u6269\u5f20\uff0c\u901a\u8fc7\u9aa8\u9ad3\u79fb\u690d\u5b9e\u9a8c\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e PD-1- \u76f8\u6bd4\uff0cPD-1+ TAMs \u8868\u73b0\u51fa\u6539\u53d8\u7684\u8868\u8fbe\u6a21\u5f0f\u548c\u5f62\u6001\u3002\u5b83\u4eec\u8868\u8fbe\u66f4\u591a\u4e0e M2 \u76f8\u5173\u7684\u6e05\u9053\u592b\u53d7\u4f53 CD206\uff0c\u8f83\u5c11\u7684 MHC II \u7c7b\uff0c\u4ee5\u53ca\u66f4\u591a\u7684 CD11c\u3002\u67d3\u8272\u7684 PD-1+ TAMs \u770b\u8d77\u6765\u5f88\u5927\u4e14\u6ce1\u6cab\u72b6\uff0c\u8868\u660e\u5b83\u4eec\u5145\u6ee1\u4e86\u7a7a\u6ce1\u548c\/\u6216\u8102\u8d28\uff0c\u7535\u5b50\u663e\u5fae\u955c\u8bc1\u5b9e\uff0c\u8fd9\u79cd\u6ce1\u6cab\u72b6\u5916\u89c2\u81f3\u5c11\u90e8\u5206\u662f\u7531\u4e8e\u7ec6\u80de\u8d28\u4e2d\u672a\u6e05\u9664\u7684\u541e\u566c\u7269\u8d28\u548c\u6eb6\u9176\u4f53\u7684\u79ef\u7d2f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u7cfb\u5217\u4f53\u5916\u548c\u4f53\u5185\u5b9e\u9a8c\u53d1\u73b0\uff0c\u4e0e T \u7ec6\u80de\u4e2d\u7684\u4f5c\u7528\u7c7b\u4f3c\uff0cTAMs \u4e0a\u7684 PD-1 \u8868\u8fbe\u8bf1\u5bfc\u4e86\u201c\u8017\u7aed\u201d\uff0c\u5e76\u901a\u8fc7\u964d\u4f4e\u5176\u541e\u566c\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\u6765\u9650\u5236\u6fc0\u6d3b\u7684 TAMs \u7684\u6548\u5e94\u529f\u80fd\u3002\u5728\u7f3a\u4e4f\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\u8bc1\u5b9e\uff0c\u901a\u8fc7\u80bf\u7624\u4e2d PD-L1 \u6572\u9664\u53ef\u4ee5\u626d\u8f6c PD-1+ TAMs \u541e\u566c\u80fd\u529b\u4e0b\u964d\u7684\u73b0\u8c61\u3002\u80bf\u7624\u4e0d\u8868\u8fbe PD-L1 \u7684\u5c0f\u9f20\u5728\u4e09\u5468\u540e\u80bf\u7624\u8d1f\u62c5\u4e5f\u51cf\u8f7b\uff0c\u4e0e\u8fc7\u8868\u8fbe PD-L1 \u7684\u80bf\u7624\u5c0f\u9f20\u76f8\u6bd4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u7528 PD-1 \u6216 PD-L1 \u963b\u65ad\u5242\u5904\u7406\u5c0f\u9f20\uff0c\u89c2\u5bdf\u5230\u80bf\u7624\u751f\u957f\u663e\u8457\u51cf\u5c11\u3002\u6e05\u9664 TAMs \u9006\u8f6c\u4e86\u8fd9\u79cd\u6548\u5e94\uff0c\u8868\u660e TAMs \u5728\u6297\u80bf\u7624\u6548\u679c\u4e2d\u7684\u76f4\u63a5\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u4e9b\u963b\u65ad\u5242\u4e0e\u6297 CD47 \u514d\u75ab\u7597\u6cd5\uff08\u5df2\u5728\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u6d4b\u8bd5\uff09\u7ed3\u5408\u4f7f\u7528\uff0c\u4ee5\u63a2\u7a76\u4e24\u79cd\u6cbb\u7597\u7c7b\u578b\u5982\u4f55\u76f8\u4e92\u4f5c\u7528\u3002\u5355\u72ec\u4f7f\u7528 PD-L1 \u548c CD47 \u963b\u65ad\u7597\u6cd5\u53ef\u4ee5\u7b49\u540c\u5730\u51cf\u5c0f\u80bf\u7624\u4f53\u79ef\uff0c\u800c\u4e24\u79cd\u7597\u6cd5\u7684\u7ed3\u5408\u663e\u793a\u51fa\u66f4\u5927\u7a0b\u5ea6\u5730\u51cf\u8f7b\u80bf\u7624\u8d1f\u62c5\u548c\u66f4\u5927\u7684\u751f\u5b58\u83b7\u76ca\u8d8b\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1\u901a\u5e38\u8ba4\u4e3a PD-1 \u8f74\u963b\u65ad\u662f\u9488\u5bf9 T \u7ec6\u80de\u7684\u6cbb\u7597\uff0c\u4f46\u5728 B \u7ec6\u80de\u3001\u6811\u7a81\u72b6\u7ec6\u80de\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4ee5\u53ca\u73b0\u5728\u7684\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u4e0a\u89c2\u5bdf\u5230\u7684 PD-1 \u8868\u8fbe\u8868\u660e\uff0c PD-1 \u8f74\u5728\u514d\u75ab\u7cfb\u7edf\u7684\u5148\u5929\u548c\u9002\u5e94\u6027\u90e8\u5206\u90fd\u5f88\u91cd\u8981\u3002\u8868\u8fbe PD-1 \u7684\u7ec6\u80de\u7c7b\u578b\u7684\u5e7f\u6cdb\u6027\u53ef\u80fd\u89e3\u91ca\u4e86\u5728 T \u7ec6\u80de\u6d3b\u6027\u53ef\u80fd\u53d7\u635f\u7684\u60c5\u51b5\u4e0bPD-1\/PD-L1 \u6291\u5236\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & Nature<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n
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\u516c\u4f17\u53f7\u53d1\u900120170524\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n

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\u2589  OncoLab\u5b9e\u9a8c\u5ba4\u7f51\u7ad9<\/strong><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f51\u7ad9\u81ea\u5e26\u68c0\u7d22\u529f\u80fd\uff0c\u53ef\u4ee5\u6839\u636e\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22<\/span>\uff0c\u5e76\u4e14\u53ef\u4ee5\u6839\u636e\u65e5\u671f\u53ca\u5185\u5bb9\u5206\u7c7b<\/span>\u8fdb\u884c\u67e5\u770b ,\u5927\u5bb6\u53ef\u4ee5\u6536\u85cf\u65b9\u4fbf\u5728\u7535\u8111\u4e0a\u67e5\u770b\u3002<\/p>\n

\u7f51\u5740\u662f\uff1aoncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u5b66\u672f\u5bfc\u822a<\/strong><\/strong><\/p>\n

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\u6b64\u5916\uff0c\u68b3\u7406\u4e86\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6512\u7684\u6536\u85cf\u5939\uff0c\u505a\u4e86\u4e00\u4e2a\u5bfc\u822a\u7f51\u9875\uff0c\u5305\u542b\u5e38\u7528\u7f51\u7ad9<\/span>\u3001\u6587\u732e\u9605\u8bfb<\/span>\u3001\u8bd5\u5242\u8ba2\u8d2d<\/span>\u3001\u57fa\u91d1\u76f8\u5173<\/span>\u3001\u5b9e\u7528\u5de5\u5177<\/span>\u3001\u5e38\u7528\u6570\u636e\u5e93<\/span>\u7b49\u5206\u7c7b\u5185\u5bb9\uff0c\u5e76\u4e14\u6574\u5408\u4e86<\/span>\u767e\u5ea6\u3001\u8c37\u6b4c\u3001\u5fc5\u5e94<\/span>\u4e09\u5927\u641c\u7d22\u5f15\u64ce\u5230\u68c0\u7d22\u5de5\u5177\u4e2d\uff0c\u6b22\u8fce\u6536\u85cf\u6216\u8bbe\u7f6e\u4e3a\u4e3b\u9875\u4f7f\u7528~<\/span><\/p>\n

\u7f51\u5740\u662f\uff1adh.<\/strong><\/span>oncolab.cn<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2589  OncoLab\u77e5\u8bc6\u661f\u7403<\/strong><\/strong><\/strong><\/strong><\/p>\n<\/section>\n

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OncoLab\u77e5\u8bc6\u661f\u7403\u4e5f\u5df2\u5f00\u901a\uff0c\u5728\u5b66\u4e60\u672c\u516c\u4f17\u53f7\u5185\u5bb9\u7684\u8fc7\u7a0b\u4e2d\u5982\u679c\u6709\u4ec0\u4e48\u9700\u8981\u8ba8\u8bba\u4ea4\u6d41\u7684\u5730\u65b9\u53ef\u4ee5\u5728\u661f\u7403\u53d1\u8868\u7559\u8a00\uff0c\u4e5f\u53ef\u4ee5\u5206\u4eab\u4e00\u4e0b\u81ea\u5df1\u7684\u5b66\u4e60\u5fc3\u5f97\u4f53\u4f1a\uff0c\u5176\u4ed6\u5c0f\u4f19\u4f34\u770b\u5230\u4e86\u53ef\u4ee5\u79ef\u6781\u7559\u8a00\u56de\u590d\uff0c\u6211\u4e5f\u4f1a\u79ef\u6781\u53c2\u4e0e\u5176\u4e2d\uff0c\u5e76\u65f6\u5e38\u653e\u4e00\u4e9b\u5b66\u4e60\u8d44\u6599\u5728\u4e0a\u9762\uff0c\u5e0c\u671b\u5927\u5bb6\u80fd\u591f\u5728\u79ef\u6781\u4ea4\u6d41\u4e92\u5e2e\u4e92\u52a9\u4e2d\u5171\u540c\u8fdb\u6b65~<\/p>\n

\u8be5\u661f\u7403\u7528\u4e8eOncoLab\u516c\u4f17\u53f7\u8bfb\u8005\u4ea4\u6d41\u5b66\u4e60\u4f7f\u7528\uff0c\u6c38\u4e45\u514d\u8d39<\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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