{"id":2938,"date":"2023-05-03T08:15:01","date_gmt":"2023-05-03T00:15:01","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/05\/03\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%ef%bc%881%ef%bc%89%ef%bc%9a%e4%b8%aa%e6%80%a7%e5%8c%96%e7%99%8c\/"},"modified":"2023-05-03T08:15:01","modified_gmt":"2023-05-03T00:15:01","slug":"2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%ef%bc%881%ef%bc%89%ef%bc%9a%e4%b8%aa%e6%80%a7%e5%8c%96%e7%99%8c","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/05\/03\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%ef%bc%881%ef%bc%89%ef%bc%9a%e4%b8%aa%e6%80%a7%e5%8c%96%e7%99%8c\/","title":{"rendered":"2023\u5e74\u5ea6\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\uff081\uff09\uff1a\u4e2a\u6027\u5316\u764c\u75c7\u75ab\u82d7"},"content":{"rendered":"
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1.\u4e2a\u6027\u5316\u764c\u75c7\u75ab\u82d7mRNA-4157\u4e0e\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08pembrolizumab\uff09\u8054\u5408\u5e94\u7528\u4e8e\u5207\u9664\u540e\u9ad8\u98ce\u9669\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u7597\u6548\u4e0e\u5b89\u5168\u6027\uff1a\u6765\u81ea\u968f\u673a\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8cmRNA-4157-P201\/Keynote-942<\/strong><\/p>\n<\/section>\n

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Jeffrey S. Weber – \u7ebd\u7ea6\u5927\u5b66\u6717\u683c\u5c3c\u533b\u5b66\u4e2d\u5fc3\uff0c\u7ebd\u7ea6<\/strong><\/p>\n<\/section>\n

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\u8fc7\u53bb\u5341\u5e74\uff0c\u65b0\u6297\u539f\u4f5c\u4e3a\u771f\u6b63\u7684\u80bf\u7624\u7279\u5f02\u6027\u3001\u514d\u75ab\u539f\u6027\u4e14\u5b89\u5168\u7684\u75ab\u82d7\u9776\u70b9\u7684\u51fa\u73b0\uff0c\u4e3a\u764c\u75c7\u75ab\u82d7\u9886\u57df\u6ce8\u5165\u4e86\u65b0\u7684\u6d3b\u529b\uff0c\u5c24\u5176\u662f\u5728\u5229\u7528\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684\u5927\u578b\u8bd5\u9a8c\u4ee4\u4eba\u5931\u671b\u4e4b\u540e\u3002\u57fa\u4e8e\u65b0\u6297\u539f\u7684\u75ab\u82d7\u80fd\u6fc0\u53d1\u5f3a\u70c8\u3001\u6301\u4e45\u7684T\u7ec6\u80de\u5e94\u7b54\uff0c\u751a\u81f3\u5f15\u53d1\u8868\u4f4d\u6269\u6563\uff0c\u8fd9\u662f\u75ab\u82d7\u6d3b\u6027\u7684\u5173\u952e\u6807\u5fd7\u3002\u610f\u8bc6\u5230\u68c0\u67e5\u70b9\u963b\u65ad\u6297\u4f53\u73b0\u5df2\u6210\u4e3a\u591a\u79cd\u75be\u75c5\uff08\u5982\u9ad8\u98ce\u9669\u9ed1\u8272\u7d20\u7624\uff09\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u4f46\u4ecd\u9700\u5728\u5e94\u7b54\u7387\u548c\u8010\u4e45\u6027\u65b9\u9762\u8fdb\u884c\u6539\u8fdb\uff0cJeffrey Weber\u63cf\u8ff0\u4e86\u4e00\u9879\u968f\u673aII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u975e\u5e38\u9f13\u821e\u4eba\u5fc3\u7684\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u5c06\u5355\u72ec\u7684\u68c0\u67e5\u70b9\u6cbb\u7597\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\uff09\u4e0e\u4e2a\u6027\u5316\u65b0\u6297\u539fmRNA\u57fa\u56e0\u764c\u75c7\u75ab\u82d7\uff08mRNA-4157\uff09\u5728\u5207\u9664\u540e\u9ad8\u98ce\u9669\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u7684\u5e94\u7528\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5229\u7528\u60a3\u8005\u80bf\u7624\u548c\u6b63\u5e38\u6837\u672c\u7684\u6838\u9178\u6d4b\u5e8f\u6765\u8bc6\u522b\u60a3\u8005\u7279\u5f02\u6027\u7a81\u53d8\uff0c\u91c7\u7528\u5148\u8fdb\u7684\u7b97\u6cd5\u9009\u62e9\u6709\u524d\u666f\u7684\u65b0\u6297\u539f\u9776\u70b9\uff0c\u4ee5\u53ca\u4e00\u4e2a\u96c6\u6210\u7684\u5236\u9020\u8fc7\u7a0b\u6765\u4e3a\u6bcf\u4e2a\u60a3\u8005\u51c6\u5907\u7f16\u7801\uff08\u4e3b\u8981\u662f\uff0934\u4e2a\u4e2a\u6027\u5316\u65b0\u6297\u539f\u9776\u70b9\u7684mRNA\uff0c157\u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u4e3a\uff082:1\uff09\u63a5\u53d7\u75ab\u82d7\u52a0\u68c0\u67e5\u70b9\u8054\u5408\u6cbb\u7597\u6216\u5355\u72ec\u68c0\u67e5\u70b9\u6cbb\u7597\u6bcf\u4e09\u5468\u4e00\u6b21\u3002\u8054\u5408\u6cbb\u7597\u5b89\u5168\u6027\u9ad8\uff0c\u4e0e\u5355\u72ec\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u76f8\u6bd4\uff0c\u8f7b\u5ea6AEs\u589e\u52a0\uff0c\u8868\u73b0\u4e3a\u201c\u5178\u578b\u7684COVID\u75ab\u82d7\u201d\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8054\u5408\u6cbb\u7597\u5728\u65e0\u590d\u53d1\u751f\u5b58\u671f\uff08RFS\uff09\u4e0a\u663e\u8457\u63d0\u9ad8\uff08\u5355\u4fa7p=0.026\uff09\uff0c\u98ce\u9669\u6bd4\u4e3a0.56\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u590d\u53d1\u98ce\u9669\u964d\u4f4e\u4e8644%\u3002RFS\u66f2\u7ebf\u5728\u7ea69\u4e2a\u6708\u65f6\u5f00\u59cb\u5206\u79bb\uff0c18\u4e2a\u6708\u7684RFS\u5728\u8054\u5408\u6cbb\u7597\u7ec4\u4e3a79%\uff0c\u5bf9\u7167\u7ec4\u4e3a62%\u3002\u5728PD-L1\u72b6\u6001\u7684\u60a3\u8005\u4e2d\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u6539\u5584\u72ec\u7acb\u4e8ePD-L1\u72b6\u6001\uff0c\u6709\u8ff9\u8c61\u8868\u660e\u5728PD-L1\u8f83\u4f4e\u7684\u60a3\u8005\u4e2d\u6548\u679c\u66f4\u5927\u3002Ryan Sullivan\u63d0\u4f9b\u7684\u72ec\u7acb\u6570\u636e\u8868\u660e\uff0c\u8fd9\u4e5f\u72ec\u7acb\u4e8e\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u3002\u6839\u636e\u8fd9\u4e9b\u7ed3\u679c\uff0c\u8ba1\u5212\u4e8e2023\u5e74\u542f\u52a8III\u671f\u7814\u7a76\uff0c\u5e76\u6269\u5c55\u5230\u5176\u4ed6\u514d\u75ab\u6cbb\u7597\u54cd\u5e94\u7ec4\u7ec7\u5b66\u7c7b\u578b\uff0c\u5982\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.\u4e2a\u6027\u5316mRNA\u65b0\u6297\u539f\u75ab\u82d7\u6cbb\u7597\u80f0\u817a\u764c<\/strong><\/p>\n<\/section>\n

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Vinod P. Balachandran – \u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3<\/strong><\/p>\n<\/section>\n

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Vinod Balachandran\u7814\u7a76\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\uff0c\u8fd9\u662f\u5178\u578b\u7684\u514d\u75ab\u5b66\u51b7\u80bf\u7624\uff0c\u5177\u6709\u4f4e\u7a81\u53d8\u8d1f\u8377\u3001\u6700\u5c0f\u7684T\u7ec6\u80de\u6d78\u6da6\u548c\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u62b5\u6297\u3002\u7136\u800c\uff0c\u7ea69%\u7684PDAC\u80bf\u7624\u662f\u70ed\u7684\uff0c\u8fd9\u7c7b\u80bf\u7624\u7684\u60a3\u8005\u751f\u5b58\u671f\u8f83\u957f\u3002\u4e3a\u4e86\u786e\u5b9a\u80fd\u6700\u6709\u6548\u5730\u5f15\u53d1\u521d\u6b21\u5e94\u7b54\u3001\u6269\u589e\u9884\u5148\u5b58\u5728\u7684\u5e94\u7b54\u6216\u4e24\u8005\u517c\u800c\u6709\u4e4b\u7684\u65b0\u6297\u539f\uff0cBalachandran\u53ca\u5176\u540c\u4e8b\u5f00\u53d1\u4e86\u4e00\u79cd\u8bc4\u4f30\u65b0\u6297\u539f\u8d28\u91cf\u7684\u6a21\u578b\uff0c\u901a\u8fc7\u9884\u6d4bMHC\u7ed3\u5408\u3001\u6f5c\u5728TCR\u53cd\u5e94\u548c\u5df2\u77e5\u75c5\u6bd2\u6297\u539f\u80bd\u76f8\u4f3c\u6027\u6765\u4f30\u7b97\u201c\u81ea\u4f53\u201d\u548c\u201c\u975e\u81ea\u4f53\u201d\u3002\u6709\u8da3\u7684\u662f\uff0c\u65b0\u6297\u539f\u8d28\u91cf\u6bd4\u65b0\u6297\u539f\u6570\u91cf\u66f4\u80fd\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u671f\uff0c\u800c\u4e14\u5728\u80f0\u817a\u764c\u957f\u671f\u751f\u5b58\u8005\u7684\u8840\u6db2\u4e2d\uff0c\u5373\u4f7f\u572810\u5e74\u540e\u4ecd\u80fd\u53d1\u73b0\u9488\u5bf9\u9ad8\u8d28\u91cf\u65b0\u6297\u539f\u7684\u7279\u5f02\u6027T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u56e2\u961f\u8fd8\u53d1\u73b0\uff0c\u5728\u957f\u671f\u751f\u5b58\u8005\u590d\u53d1\u80bf\u7624\u4e2d\uff0c\u9ad8\u8d28\u91cf\u65b0\u6297\u539f\u53ef\u80fd\u88ab\u7f16\u8f91\uff0c\u81ea\u53d1\u4ea7\u751f\u9ad8\u8d28\u91cf\u65b0\u6297\u539f\u53ef\u80fd\u5bfc\u81f4\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u589e\u591a\uff0c\u4ece\u800c\u5ef6\u8fdf\u80bf\u7624\u590d\u53d1\u3002\u8003\u8651\u5230\u51e0\u4e4e\u6240\u6709PDAC\u90fd\u643a\u5e26\u6709\u4e0d\u540c\u9884\u6d4b\u514d\u75ab\u539f\u6027\u7684\u65b0\u6297\u539f\u5e93\uff0cBalachandran\u53ca\u5176\u540c\u4e8b\u60f3\u77e5\u9053RNA\u75ab\u82d7\u662f\u5426\u53ef\u4ee5\u7528\u6765\u6fc0\u53d1\u521d\u6b21\u5e94\u7b54\u3002\u5728\u4e00\u9879\u5408\u4f5c\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u4e3a\u80f0\u817a\u764c\u5f00\u53d1\u4e86\u4e2a\u6027\u5316\u7684mRNA\u75ab\u82d7\u3002\u5728I\u671f\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u63a5\u53d7\u624b\u672f\u6cbb\u7597\uff0c\u7136\u540e\u5728\u7b2c6\u5468\u5f00\u59cb\u63a5\u53d7\u963f\u7279\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u7b2c9\u5468\u5f00\u59cb\u63a5\u53d78\u6b21\u8fde\u7eed\u7684\u4e2a\u6027\u5316\u764c\u75c7\u75ab\u82d7\u6cbb\u7597\uff0c\u7b2c21\u5468\u5f00\u59cb\u63a5\u53d7\u6807\u51c6\u5316\u7597\uff0c\u6700\u540e\u5728\u7b2c46\u5468\u8fdb\u884c\u665a\u671f\u8865\u5145\u3002\u5c3d\u7ba1\u8fd9\u9879\u8bd5\u9a8c\u53d7\u5230\u4e86COVID-19\u5927\u6d41\u884c\u7684\u5f71\u54cd\uff0c\u4f46\u5728\u63a5\u53d7\u963f\u7279\u73e0\u5355\u6297\u6cbb\u7597\u768419\u540d\u60a3\u8005\u4e2d\u670916\u540d\u7ee7\u7eed\u63a5\u53d7\u75ab\u82d7\u6cbb\u7597\uff0c\u8bc1\u660e\u4e86\u5728\u624b\u672f\u540e\u751f\u6210\u548c\u7ed9\u4e88\u5b9a\u5236\u75ab\u82d7\u7684\u53ef\u884c\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u901a\u8fc7\u4f7f\u7528\u4e3b\u8981\u7684ELISpot\u5206\u6790\u548c\u786e\u8ba4\u6027TCR\u6d4b\u5e8fCloneTrack\u6d4b\u8bd5\u6765\u76d1\u6d4b\u75ab\u82d7\u8bf1\u5bfc\u7684T\u7ec6\u80de\u5e94\u7b54\uff0c\u7ed3\u679c\u663e\u793a\u75ab\u82d7\u63a5\u79cd\u540e\u7684\u5e94\u7b54\u5f3a\u70c8\u4e14\u6301\u4e45\uff0c\u5373\u4f7f\u5728\u5316\u7597\u540e\u4e5f\u80fd\u7ef4\u6301\u3002\u6839\u636e\u75ab\u82d7\u8bf1\u5bfc\u7684\u5916\u5468\u8840\u514b\u9686\u8f68\u8ff9\u5bf9\u514b\u9686\u8fdb\u884c\u805a\u7c7b\uff0c\u8868\u660emRNA\u75ab\u82d7\u6269\u589e\u7684\u591a\u514b\u9686T\u7ec6\u80de\u5e93\u5305\u62ec\u5728\u75ab\u82d7\u63a5\u79cd\u524d\u65e0\u6cd5\u68c0\u6d4b\u5230\u7684\u514b\u9686\uff0c\u4e14\u4e0e\u6297PD-L1\u6269\u589e\u7684\u5e93\u6709\u6240\u4e0d\u540c\u3002\u7279\u522b\u662f\u5728\u75ab\u82d7\u589e\u5f3a\u5242\u540e\uff0c\u75ab\u82d7\u8bf1\u5bfc\u7684\u514b\u9686\u6269\u589e\u5f97\u5230\u8fdb\u4e00\u6b65\u52a0\u5f3a\uff0c\u800cPD-L1\u8bf1\u5bfc\u7684\u514b\u9686\u5219\u6ca1\u6709\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u75ab\u82d7\u6269\u589e\u7684\u514b\u9686\u5728\u63a5\u79cd\u524d\u6536\u96c6\u7684\u80bf\u7624\u4e2d\u6ca1\u6709\u53d1\u73b0\uff0c\u8fd9\u8868\u660e\u75ab\u82d7\u53ef\u80fd\u5728\u5f15\u53d1\u521d\u6b21\u5e94\u7b54\u3002\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u73b0\uff0c\u8bb8\u591a\u5728\u5916\u5468\u8840\u6269\u589e\u7684T\u7ec6\u80de\u514b\u9686\u5b9e\u9645\u4e0a\u662f\u65b0\u6297\u539f\u7279\u5f02\u6027\u7684\uff0c\u5373\u4f7f\u5728\u603b\u514b\u9686\u6269\u589e\u8f83\u5c11\u7684\u60a3\u8005\u4e2d\u4e5f\u662f\u5982\u6b64\u3002\u5bf9\u4e8e\u663e\u793a\u51fa\u521d\u6b21ELISpot\u6d3b\u6027\u548c\u786e\u8ba4\u6027\u514b\u9686\u6269\u589e\u7684\u60a3\u8005\uff0c\u5c06\u5176\u5f52\u7c7b\u4e3amRNA\u65b0\u6297\u539f\u75ab\u82d7\u5e94\u7b54\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4f53\u800c\u8a00\uff0cmRNA\u75ab\u82d7\u572850%\u7684PDAC\u60a3\u8005\u4e2d\u8bf1\u5bfc\u4e86T\u7ec6\u80de\u5e94\u7b54\uff0c\u5176\u4e2d\u8bb8\u591a\u5e94\u7b54\u90fd\u662f\u663e\u8457\u4e14\u6301\u4e45\u7684\u3002\u5728\u4e2d\u4f4d\u968f\u8bbf18\u4e2a\u6708\u540e\uff0c\u5e94\u7b54\u8005\u5c1a\u672a\u8fbe\u5230\u4e2d\u4f4d\u65e0\u590d\u53d1\u751f\u5b58\u671f\uff0c\u800c\u975e\u5e94\u7b54\u8005\u7684\u4e2d\u4f4d\u65e0\u590d\u53d1\u751f\u5b58\u671f\u4e3a13.4\u4e2a\u6708\u3002\u963f\u7279\u73e0\u5355\u6297\u6cbb\u7597\u3001\u6807\u51c6\u9884\u540e\u53d8\u91cf\u5dee\u5f02\uff08\u6dcb\u5df4\u7ed3\u72b6\u6001\u6216\u5207\u9664\u8fb9\u7f18\uff09\u3001\u5316\u7597\u5468\u671f\u6216\u539f\u53d1\u80bf\u7624\u4e2d\u7684T\u7ec6\u80de\u5bc6\u5ea6\u4e0e\u590d\u53d1\u4e4b\u95f4\u6ca1\u6709\u7c7b\u4f3c\u7684\u76f8\u5173\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8003\u8651\u5230\u975e\u5e94\u7b54\u8005\u53ef\u80fd\u5bf9mRNA\u75ab\u82d7\u7684\u9002\u5e94\u6027\u8f83\u4f4e\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u60a3\u8005\u5bf9COVID-19\u75ab\u82d7\u7684\u5e94\u7b54\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u53d1\u73b0\u764c\u75c7\u75ab\u82d7\u5e94\u7b54\u8005\u548c\u975e\u5e94\u7b54\u8005\u5bf9COVID-19\u75ab\u82d7\u7684\u5e94\u7b54\u76f8\u4f3c\uff0c\u6392\u9664\u4e86\u57fa\u7ebf\u514d\u75ab\u9002\u5e94\u6027\u4f5c\u4e3a\u5f71\u54cd\u56e0\u7d20\u3002\u7136\u800c\uff0c\u4ed6\u4eec\u53d1\u73b0\uff0c\u5e94\u7b54\u8005\u5177\u6709\u66f4\u591a\u7684\u514b\u9686\u7a81\u53d8\u548c\u66f4\u9ad8\u8d28\u91cf\u7684\u65b0\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e00\u4e2a\u4e34\u5e8a\u6848\u4f8b\u4e2d\uff0cBalachandran\u63cf\u8ff0\u4e86\u4e00\u4f4d\u60a3\u8005\uff0c\u4ed6\u4f3c\u4e4e\u6709\u8f6c\u79fb\u7684\u8bc1\u636e\uff0c\u8fd8\u6709\u4e00\u4e2a\u53ef\u7591\u7684\u809d\u810f\u75c5\u53d8\uff0c\u540e\u6765\u8bc1\u5b9e\u662f\u75ab\u82d7\u6269\u589e\u7684T\u7ec6\u80de\u514b\u9686\u7684\u6dcb\u5df4\u6837\u805a\u96c6\u4f53\uff0c\u5728\u540e\u7eed\u7684\u5f71\u50cf\u68c0\u67e5\u4e2d\u6d88\u5931\u4e86\u3002\u8fd9\u4e00\u7ed3\u679c\u53ef\u80fd\u8868\u660e\u75ab\u82d7\u8bf1\u5bfc\u7684\u514d\u75ab\u5bf9\u5fae\u8f6c\u79fb\u7684\u63a7\u5236\u3002\u5c55\u671b\u672a\u6765\uff0cBalachandran\u53ca\u5176\u540c\u4e8b\u5c06\u8fdb\u884c\u8be5\u75ab\u82d7\u7b56\u7565\u7684\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u6b63\u5728\u8003\u8651\u5c06\u6b64\u6cbb\u7597\u6269\u5c55\u81f3\u5176\u4ed6\u5bf9\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u4e0d\u654f\u611f\u7684\u764c\u75c7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.T\u7ec6\u80de\u7279\u5f02\u6027\u3001\u8868\u578b\u548c\u52a8\u6001\uff1a\u5bf9\u764c\u75c7\u75ab\u82d7\u7684\u5f71\u54cd<\/strong><\/p>\n<\/section>\n

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Catherine J. Wu – Dana-Farber\u764c\u75c7\u7814\u7a76\u6240\uff0c\u6ce2\u58eb\u987f\uff0cMA<\/strong><\/p>\n<\/section>\n

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\u5728\u6765\u81ea\u56db\u540d\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u6570\u636e\u4e2d\u8bc4\u4f30TIL\u666f\u89c2\u65f6\uff0cWu\u53ca\u5176\u540c\u4e8b\u4f7f\u7528\u805a\u7c7b\u5206\u6790\u7ed8\u5236\u4e86\u4e0d\u540c\u7684CD8+T\u7ec6\u80de\u8868\u578b\uff0c\u5e76\u5173\u6ce8\u4e86\u4e24\u4e2a\u6700\u5927\u7684\u79cd\u7fa4\uff1a\u8017\u7aed\u6548\u5e94\u7ec6\u80de\u548c\u975e\u8017\u7aed\u8bb0\u5fc6\u7ec6\u80de\u3002\u4ece\u8fd9\u4e9b\u7ec4\u4e2d\u7684\u4e3b\u5bfc\u514b\u9686\u578b\u4e2d\u91cd\u5efaTCR\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\u8017\u7aed\u7684T\u7ec6\u80de\u6bd4\u975e\u8017\u7aed\u7684\u8bb0\u5fc6\u7ec6\u80de\u5177\u6709\u66f4\u9ad8\u7684\u80bf\u7624\u7279\u5f02\u6027\uff0c\u800c\u975e\u8017\u7aed\u7684\u8bb0\u5fc6\u7ec6\u80de\u5219\u66f4\u503e\u5411\u4e8e\u75c5\u6bd2\u7279\u5f02\u6027\u3002CD4+T\u7ec6\u80de\u4e5f\u53ef\u4ee5\u5212\u5206\u4e3a\u4e0d\u540c\u7684\u8868\u578b\uff0c\u5206\u4e3a\u8017\u7aed\u3001\u975e\u8017\u7aed\u8bb0\u5fc6\u6216Tregs\u3002\u6709\u8da3\u7684\u662f\uff0cTregs\u4e2d\u89c2\u5bdf\u5230\u6700\u9ad8\u7684\u80bf\u7624\u7279\u5f02\u6027\u3002\u56db\u540d\u8bc4\u4f30\u60a3\u8005\u4e2d\u7684\u6bcf\u4e00\u540d\u90fd\u663e\u793a\u51fa\u975e\u5e38\u4e0d\u540c\u7684\u6297\u539f\u7279\u5f02\u6027\u5256\u9762\uff0c\u663e\u793a\u4e86\u5bf9\u9ed1\u8272\u7d20\u7624\u76f8\u5173\u6297\u539f\uff08MAA\uff09\u3001\u65b0\u6297\u539f\u548c\u75c5\u6bd2\u6297\u539f\u7684\u591a\u79cd\u7279\u5f02\u6027\uff0c\u5176\u4e2d\u65b0\u6297\u539f\u7279\u5f02\u6027TCR\u4e0eMAA\u7279\u5f02\u6027TCR\u76f8\u6bd4\u5177\u6709\u66f4\u9ad8\u7684\u4eb2\u548c\u529b\u3002\u9664\u9ed1\u8272\u7d20\u7624\u5916\uff0c\u7814\u7a76\u4eba\u5458\u5728\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u548c\u5934\u9888\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u7684\u6570\u636e\u4e2d\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7684\u805a\u7c7b\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f5c\u4e3a2023\u5e74AACR\u5b66\u9662\u65b0\u4efb\u7814\u7a76\u5458\u7684Catherine Wu\u5728\u8bb2\u8bdd\u5f00\u59cb\u65f6\u8ba8\u8bba\u4e86\u764c\u75c7\u75ab\u82d7\u5982\u4f55\u6709\u6f5c\u529b\u5e94\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u9762\u4e34\u7684\u4e00\u7cfb\u5217\u6311\u6218\uff0c\u4ece\u80bf\u7624\u5f02\u8d28\u6027\u548c\u8fdb\u5316\u5230\u514d\u75ab\u4e0d\u5e94\u7b54\uff0c\u56e0\u4e3a\u764c\u75c7\u75ab\u82d7\u65e2\u53ef\u4ee5\u5229\u7528\u5df2\u5b58\u5728\u7684\u80bf\u7624\u514d\u75ab\uff0c\u4e5f\u53ef\u4ee5\u8bf1\u5bfc\u65b0\u7684\u5e94\u7b54\u3002\u764c\u75c7\u75ab\u82d7\u5f00\u53d1\u4e2d\u4e00\u4e2a\u91cd\u8981\u7684\u969c\u788d\u662f\u8bc6\u522b\u80bf\u7624\u7279\u5f02\u6027TCR\uff0c\u5b83\u4eec\u5728\u539f\u751f\u6001\u73af\u5883\u4e2d\u76f8\u5bf9\u7a00\u5c11\uff0c\u5e76\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u65c1\u89c2\u8005T\u7ec6\u80de\u6df7\u5408\u3002\u5bf9\u4e8eWu\u53ca\u5176\u56e2\u961f\uff0c\u8bc6\u522b\u76f8\u5173\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u6d89\u53ca\u7efc\u5408\u8003\u8651TCR\u5e8f\u5217\u548cT\u7ec6\u80de\u8868\u578b\uff0c\u8fd9\u57fa\u4e8e\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\u7684\u8fdb\u6b65\u4ee5\u53ca\u901a\u8fc7\u8d28\u8c31\u548c\u5176\u4ed6\u6280\u672f\u63d0\u9ad8\u6f5c\u5728\u9776\u6297\u539f\u8bc6\u522b\u3002\u8fd9\u79cd\u8054\u7cfb\u662f\u901a\u8fc7\u4f7f\u7528\u7ec4\u5408\u67d3\u6599\u6807\u8bb0\u7cfb\u7edf\u5b9e\u73b0\u7684\uff0c\u8be5\u7cfb\u7edf\u5141\u8bb8\u5bf9\u5927\u91cfTCR\u5019\u9009\u8005\u8fdb\u884c\u9ad8\u901a\u91cf\u7b5b\u9009\uff0c\u4ee5\u786e\u4fdd\u5bf9\u80bf\u7624\u548c\u9776\u6297\u539f\u7684\u7279\u5f02\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u4e0d\u540c\u89d2\u5ea6\u8bc4\u4f30\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\uff0cWu\u53ca\u5176\u540c\u4e8b\u5229\u7528\u57fa\u4e8eSlide-seq\u7684\u6280\u672f\u7814\u7a76\u4e86\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7ec6\u80de\u4e4b\u95f4\u7684\u7a7a\u95f4\u5173\u7cfb\uff0c\u8be5\u6280\u672f\u53ef\u4ee5\u5728\u7ec4\u7ec7\u5207\u7247\u4e2d\u5206\u6790RNA\u3001DNA\u548cTCR\u3002\u4f7f\u7528\u8fd9\u4e2a\u7cfb\u7edf\uff0c\u7814\u7a76\u4eba\u5458\u80fd\u591f\u786e\u5b9a\u4e0e\u80bf\u7624\u8fb9\u7f18\u76f8\u6bd4\u5728\u80bf\u7624\u5185\u88ab\u8017\u7aed\u6216\u5bcc\u96c6\u7684TCR\u3002\u901a\u8fc7\u5c06Slide-seq\u4e0e\u4eba\u7c7b\u9ed1\u8272\u7d20\u7624\u4e2d\u7684TCRseq\u7ed3\u5408\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u5206\u6790\u6837\u672c\u7684\u591a\u4e2a\u533a\u57df\uff0c\u5e76\u8bc6\u522b\u51fa\u7b2c\u4e09\u7ea7\u6dcb\u5df4\u7ed3\u6784\u3002\u4e00\u4e2a\u6709\u8da3\u7684\u6837\u672c\u7531\u4e24\u4e2a\u53f6\u5b50\u7ec4\u6210\uff0c\u663e\u793a\u51fa\u4e00\u4e2a\u4ec5\u9650\u4e8e\u4e00\u4e2a\u53f6\u5b50\u7684TCR\uff0c\u8868\u73b0\u51fa\u7a7a\u95f4\u504f\u89c1\u3002\u89c2\u5bdf\u5176\u73af\u5883\u5173\u7cfb\uff0c\u8fd9\u4e0e\u8d8b\u5316\u56e0\u5b50CXCL10\u5448\u6b63\u76f8\u5173\uff0c\u4e0e\u5148\u524d\u4e0e\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u7684MGST1\u5448\u8d1f\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4f53\u800c\u8a00\uff0c\u4ece\u9ed1\u8272\u7d20\u7624\u7684TIL\u666f\u89c2\u6765\u770b\uff0cWu\u8ba4\u4e3a\u5bf9\u514d\u75ab\u6cbb\u7597\u6700\u6709\u76ca\u7684T\u7ec6\u80de\u7279\u5f02\u6027\u4e0d\u5e78\u5df2\u7ecf\u8017\u5c3d\u3002\u4e3a\u4e86\u5bfb\u627e\u6062\u590d\u6216\u66ff\u4ee3\u5b83\u4eec\u7684\u65b9\u6cd5\uff0cWu\u8f6c\u5411\u4e86\u8bc6\u522b\u4e2a\u6027\u5316\u65b0\u6297\u539f\u548c\u5236\u5907\u4e2a\u6027\u5316\u764c\u75c7\u75ab\u82d7\u3002\u57282017\u5e74\u4e24\u4e2a\u72ec\u7acb\u5c0f\u7ec4\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u9488\u5bf9\u4e2a\u6027\u5316\u65b0\u6297\u539f\u7684\u80bd\u75ab\u82d7\u548cRNA\u75ab\u82d7\u5728\u4e0e\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u8054\u5408\u4f7f\u7528\u65f6\u90fd\u663e\u793a\u51fa\u5b89\u5168\u6027\u3001\u53ef\u884c\u6027\u3001\u514d\u75ab\u539f\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4f53\u800c\u8a00\uff0c\u4ece\u9ed1\u8272\u7d20\u7624\u7684TIL\u666f\u89c2\u6765\u770b\uff0cWu\u8ba4\u4e3a\u5bf9\u514d\u75ab\u6cbb\u7597\u6700\u6709\u76ca\u7684T\u7ec6\u80de\u7279\u5f02\u6027\u4e0d\u5e78\u5df2\u7ecf\u8017\u5c3d\u3002\u4e3a\u4e86\u5bfb\u627e\u6062\u590d\u6216\u66ff\u4ee3\u5b83\u4eec\u7684\u65b9\u6cd5\uff0cWu\u8f6c\u5411\u4e86\u8bc6\u522b\u4e2a\u6027\u5316\u65b0\u6297\u539f\u548c\u5236\u5907\u4e2a\u6027\u5316\u764c\u75c7\u75ab\u82d7\u3002\u57282017\u5e74\u4e24\u4e2a\u72ec\u7acb\u5c0f\u7ec4\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u9488\u5bf9\u4e2a\u6027\u5316\u65b0\u6297\u539f\u7684\u80bd\u75ab\u82d7\u548cRNA\u75ab\u82d7\u5728\u4e0e\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u8054\u5408\u4f7f\u7528\u65f6\u90fd\u663e\u793a\u51fa\u5b89\u5168\u6027\u3001\u53ef\u884c\u6027\u3001\u514d\u75ab\u539f\u6027\u548c\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & AACR<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n

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\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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