{"id":2942,"date":"2023-05-05T07:01:11","date_gmt":"2023-05-04T23:01:11","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/05\/05\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%89%ef%bc%9at%e7%bb%86%e8%83%9e%e7%94%9f%e7%89%a9%e5%ad%a6\/"},"modified":"2023-05-05T07:01:11","modified_gmt":"2023-05-04T23:01:11","slug":"2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%89%ef%bc%9at%e7%bb%86%e8%83%9e%e7%94%9f%e7%89%a9%e5%ad%a6","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/05\/05\/2023%e5%b9%b4%e5%ba%a6%e7%be%8e%e5%9b%bd%e7%99%8c%e7%97%87%e7%a0%94%e7%a9%b6%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%89%ef%bc%9at%e7%bb%86%e8%83%9e%e7%94%9f%e7%89%a9%e5%ad%a6\/","title":{"rendered":"2023\u5e74\u5ea6\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u4e09\uff1aT\u7ec6\u80de\u751f\u7269\u5b66\u4e0e\u76f8\u5173\u7597\u6cd5"},"content":{"rendered":"
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1.CD40\u6fc0\u52a8\u5242\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5c06\u8c03\u8282\u6027T\u7ec6\u80de\u8f6c\u5316\u4e3a1\u578b\u6548\u5e94\u7ec6\u80de<\/strong><\/p>\n<\/section>\n

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Katelyn T. Byrne – Brenden-Colson Center for Pancreatic Care\uff0c\u4fc4\u52d2\u5188\u5065\u5eb7\u4e0e\u79d1\u5b66\u5927\u5b66\uff0c\u6ce2\u7279\u5170\uff0c\u4fc4\u52d2\u5188\u5dde<\/strong><\/p>\n<\/section>\n

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\u5728\u8bc1\u5b9e\u8fd9\u79cd\u6548\u5e94\u786e\u5b9e\u662f\u7531\u4e8e\u6fc0\u52a8\u5242\u6297CD40\u800c\u4e0d\u662f\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u4e4b\u540e\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u7814\u7a76\u8fd9\u79cd\u73b0\u8c61\u80cc\u540e\u7684\u673a\u5236\u3002\u7531\u4e8eTregs\u4e0d\u8868\u8fbeCD40\uff0c\u7814\u7a76\u5c0f\u7ec4\u5047\u8bbe\u6297\u539f\u5448\u9012\u7ec6\u80de\u53ef\u80fd\u8d77\u5230\u4e86\u4f5c\u7528\uff0c\u5e76\u53d1\u73b0DCs\u548cMHC-II\u662f\u6297CD40\u4ecb\u5bfc\u7684Treg\u51cf\u5c11\u6240\u5fc5\u9700\u7684\u3002\u6b64\u5916\uff0cTreg\u51cf\u5c11\u8fd8\u9700\u8981IL-12p40\u3001IFN\u03b3\u548c\u5bbf\u4e3b\u8868\u8fbe\u7684IFN\u03b3\u53d7\u4f53\u3002\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u63a2\u7d22\u4e86Tregs\u662f\u5728TME\u4e2d\u6b7b\u4ea1\u8fd8\u662f\u8f6c\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u7814\u7a76Treg\u7684\u8f6c\u5316\uff0c\u7814\u7a76\u4eba\u5458\u5728\u63a5\u53d7\u53cc\u91cd\u68c0\u67e5\u70b9\u963b\u65ad\u548c\u6fc0\u52a8\u5242\u6297CD40\u6cbb\u7597\u7684\u5e26\u7624\u5c0f\u9f20\u4e2d\u8ffd\u8e2a\u4e86Foxp3\u548cTbet\uff0c\u5e76\u89c2\u5bdf\u5230ExTregs\u7684\u6570\u91cf\u589e\u52a0\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u6cbb\u7597\u540e\u5931\u53bb\u4e86Foxp3\u7684\u8868\u8fbe\u3002\u901a\u8fc7\u8ffd\u8e2aFoxp3\u548cTbet\u7684\u8868\u8fbe\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u53d1\u73b0\u6297CD40\u8bf1\u5bfc\u7684ExTregs\u83b7\u5f97\u4e86IFN\u03b3\u6548\u5e94\u529f\u80fd\uff0c\u5e76\u5728\u6cbb\u7597\u540e\u663e\u793a\u51fa\u589e\u52a0\u7684NFAT\u4fe1\u53f7\uff0c\u8fd9\u8868\u660eTCR\u7ed3\u5408\u589e\u52a0\u3002\u5728\u60a3\u8005\u63a5\u53d7\u6fc0\u52a8\u5242CD40\u6cbb\u759712\u5929\u540e\u7684\u6837\u672c\u4e2d\uff0cByrne\u53ca\u5176\u540c\u4e8b\u89c2\u5bdf\u5230\u4e86\u4e0e\u5c0f\u9f20\u7c7b\u4f3c\u7684\u6a21\u5f0f\uff0c\u80bf\u7624\u4e2dTregs\u51cf\u5c11\uff0cTbet+ Tregs\u589e\u52a0\uff0c\u8fb9\u754c\u533a\u57df\u4e2d\u7684Tregs\u548cTbet+ Tregs\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u4e4b\uff0c\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u6fc0\u52a8\u5242\u6297CD40\u901a\u8fc7\u8bf1\u5bfcAPCs\u4e2d\u7684\u53d8\u5316\uff0c\u5c06\u80f0\u817a\u80bf\u7624\u4e2d\u7684Treg\u91cd\u65b0\u7f16\u7a0b\u4e3aTh1\u6837ExTregs\uff0c\u4ece\u800c\u514b\u670d\u4e86Treg\u4ecb\u5bfc\u7684\u514d\u75ab\u62b5\u6297\uff0c\u8fd9\u79cd\u73b0\u8c61\u5728\u60a3\u8005\u548c\u5c0f\u9f20\u4e2d\u5747\u6709\u89c2\u5bdf\u5230\u3002\u901a\u8fc7\u8fd9\u4e9b\u7ed3\u679c\uff0cByrne\u6307\u51fa\u4e86\u5728\u6fc0\u52a8\u5242\u6297CD40\u6cbb\u7597\u540e\u91cd\u65b0\u8003\u8651TME\u4e2d\u5b58\u5728\u7684\u80bf\u7624\u53cd\u5e94\u6027T\u7ec6\u80de\u7fa4\u7684\u91cd\u8981\u6027\uff0c\u4ee5\u53ca\u5229\u7528Treg\u53ef\u5851\u6027\u6539\u5584\u60a3\u8005\u9884\u540e\u7684\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.\u9488\u5bf9\u9a71\u52a8\u7a81\u53d8\u7684TCR\u57fa\u56e0\u7597\u6cd5<\/strong><\/p>\n<\/section>\n

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Eric Tran – \u4fc4\u52d2\u5188\u5dde\u6ce2\u7279\u5170\u5e02\u666e\u7f57\u7ef4\u767b\u65af\u764c\u75c7\u7814\u7a76\u6240<\/strong><\/p>\n<\/section>\n

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\u9274\u4e8e\u80bf\u7624\u4e2d\u7684\u9a71\u52a8\u7a81\u53d8\u5177\u6709\u514b\u9686\u6027\uff0c\u5e76\u4e14\u9700\u8981\u8bb8\u591a\u9a71\u52a8\u57fa\u56e0\u6765\u7ef4\u6301\u80bf\u7624\u5b58\u6d3b\u548c\/\u6216\u751f\u957f\u4f18\u52bf\uff0c\u56e0\u6b64\u9776\u5411\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u7684TCR\u5728TCR\u5de5\u7a0b\u6027T\u7ec6\u80de\u7597\u6cd5\u4e2d\u53ef\u80fd\u7279\u522b\u6709\u4f18\u52bf\u3002Eric Tran\u5c55\u793a\u4e86\u4e00\u4f4d\u60a3\u6709\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\u3001\u80ba\u8f6c\u79fb\u7684\u60a3\u8005\u63a5\u53d7\u9488\u5bf9KRAS G12D\u7a81\u53d8\u7684TCR\u5de5\u7a0b\u5316T\u7ec6\u80de\u6cbb\u7597\u7684\u6700\u65b0\u6570\u636e\u3002\u60a3\u8005\u7684T\u7ec6\u80de\u901a\u8fc7\u4e24\u79cd\u9488\u5bf9\u4e0eHLA-C-0802\u7ed3\u5408\u7684Kras\u7a81\u53d89mer\u548c10mer\u80bd\u7684TCR\u8fdb\u884c\u5de5\u7a0b\u5316\uff0c\u5e76\u5728IL-2\u3001IL-7\u3001IL-21\u4ee5\u53caTGF\u03b2\u5b58\u5728\u4e0b\u6269\u589e\uff0c\u8bd5\u56fe\u8bf1\u5bfc\u7ec4\u7ec7\u9a7b\u7559\u8868\u578b\u3002T\u7ec6\u80de\u4ea7\u54c1\u662f\u643a\u5e26\u9488\u5bf99mer\u548c10mer\u80bd\u7279\u5f02\u6027TCR\u7684T\u7ec6\u80de\u76841:2\u6df7\u5408\u7269\u3002\u5728\u8f93\u6ce8\u524d\uff0c\u60a3\u8005\u63a5\u53d7\u4e86\u6297IL-6\u6297\u4f53\uff0c\u4ee5\u51cf\u8f7b\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u75c7(CRS)\u7684\u4e25\u91cd\u7a0b\u5ea6\uff0c\u8fdb\u884c\u6807\u51c6\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff0c\u5e76\u63a5\u53d7\u4e866\u6b21\u8ba1\u5212\u5242\u91cf\u4e2d\u76845\u6b21IL-2\u652f\u6301\u6cbb\u7597\u3002T\u7ec6\u80de\u8f93\u6ce8\u540e6\u4e2a\u6708\uff0c\u60a3\u8005\u80ba\u75c5\u7076\u7684RECIST\u7f29\u5c0f\u4e8672%\uff0c\u5de5\u7a0b\u5316T\u7ec6\u80de\u7ea6\u5360\u60a3\u8005\u6240\u6709\u5faa\u73afT\u7ec6\u80de\u76842.5%\u3002\u8be5\u53cd\u5e94\u6301\u7eed\u52301\u5e74\uff0c\u4f46\u968f\u540e\u60a3\u8005\u9010\u6e10\u6076\u5316\uff0c\u80ba\u75c5\u7076\u9700\u8981\u8fdb\u4e00\u6b65\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3.\u5256\u6790\u80bf\u7624\u5e72\u7ec6\u80de\u9003\u907fT\u7ec6\u80de\u653b\u51fb\u7684\u673a\u5236<\/strong><\/p>\n<\/section>\n

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Judith Agudo – Dana-Farber Cancer Institute\uff0c\u6ce2\u58eb\u987f\uff0cMA<\/strong><\/p>\n<\/section>\n

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\u5355\u7ec6\u80deRNAseq\u3001\u514d\u75ab\u7ec4\u5316\u548cFACS\u5206\u6790\u663e\u793a\uff0c\u4e0e\u91ce\u751f\u578b\u80bf\u7624\u76f8\u6bd4\uff0cSox17\u6572\u9664\u578b\u4e2d\u6548\u5e94\u7c7bIFN\u03b3+ CD8+ T\u7ec6\u80de\u6d78\u6da6\u589e\u52a0\uff0c\u51e0\u4e4e\u6ca1\u6709\u8017\u7aed\u7684CD8+ T\u7ec6\u80de\u3002CD8+ T\u7ec6\u80de\u8017\u7aed\u6062\u590d\u4e86Sox17\u6572\u9664\u578b\u80bf\u7624\u7684\u751f\u957f\u3002\u6b64\u5916\uff0cSox17\u4e27\u5931\u8bf1\u5bfc\u4e86\u5e72\u6270\u7d20\u57fa\u56e0\u7279\u5f81\u7684\u5bcc\u96c6\uff0c\u901a\u8fc7\u4e0a\u8c03IFNAR1\u548cMHC I\u7c7b\u589e\u52a0IFN\u03b3\u4fe1\u53f7\u4f20\u5bfc\u3002\u66f4\u591a\u5b9e\u9a8c\u8868\u660eSox17\u76f4\u63a5\u6291\u5236\u8fd9\u4e9b\u7c7b\u5668\u5b98\u4e2d\u7684IFN\u53d7\u4f53\u8868\u8fbe\uff0c\u800cIFNGR1\u7684\u6572\u9664\u6062\u590d\u4e86Sox17\u6572\u9664\u578b\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4.\u80bf\u7624\u76f8\u5173\u6dcb\u5df4\u7ba1\u53caT\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u8f6c\u79fb<\/strong><\/p>\n<\/section>\n

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Amanda W. Lund – \u7ebd\u7ea6\u5927\u5b66Langone Health Perlmutter\u764c\u75c7\u4e2d\u5fc3\uff0c\u7ebd\u7ea6<\/strong><\/p>\n<\/section>\n

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Amanda Lund\u8ba8\u8bba\u4e86\u80bf\u7624\u4e2d\u6dcb\u5df4\u7ba1\u7684\u76f8\u5173\u6027\uff0c\u8fd9\u662f\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7ecf\u5e38\u88ab\u5ffd\u89c6\u7684\u4e00\u4e2a\u7279\u5f81\u3002\u6dcb\u5df4\u7ba1\u671d\u7740\u6dcb\u5df4\u7ed3\u5355\u5411\u6d41\u52a8\uff0c\u53ef\u4ee5\u5bf9\u5176\u73af\u5883\u4e2d\u7684\u4fe1\u53f7\uff08\u5982VEGFA\u3001IFN\u03b3\uff09\u505a\u51fa\u52a8\u6001\u53cd\u5e94\uff0c\u4f7f\u5b83\u4eec\u5728\u80bf\u7624\u4e2d\u53d1\u6325\u591a\u79cd\u4f5c\u7528\uff0c\u4ece\u80bf\u7624\u8f6c\u79fb\u5230\u514d\u75ab\u4ecb\u5bfc\u548c\u5e72\u7ec6\u80de\u751f\u6001\u4f4d\u7684\u63a7\u5236\u3002\u5728\u6700\u8fd1\u7684\u5de5\u4f5c\u4e2d\uff0cLund\u53ca\u5176\u540c\u4e8b\u7814\u7a76\u4e86\u6dcb\u5df4\u7ba1\u5982\u4f55\u8c03\u8282\u5f00\/\u5173\u4fe1\u53f7\u4ee5\u9a71\u52a8\u5bf9\u764c\u75c7\u7684\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Attaya Suvannasankha – \u5370\u7b2c\u5b89\u7eb3\u5927\u5b66\u897f\u8499\u764c\u75c7\u4e2d\u5fc3\u548cRoudebush VAMC\uff0c\u5370\u7b2c\u5b89\u7eb3\u6ce2\u5229\u65af\uff0c\u5370\u7b2c\u5b89\u7eb3\u5dde<\/strong><\/p>\n<\/section>\n

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\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & AACR<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/span><\/p>\n


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\u5173\u6ce8\u672c\u53f7~<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

1.CD40\u6fc0\u52a8\u5242\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5c06\u8c03\u8282\u6027T\u7ec6\u80de\u8f6c\u5316\u4e3a1\u578b\u6548\u5e94\u7ec6\u80de Katelyn T. Byrne &#821…<\/p>\n","protected":false},"author":1,"featured_media":2941,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[76],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2942"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=2942"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/2942\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/2941"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=2942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=2942"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=2942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}