{"id":3087,"date":"2023-07-01T00:45:31","date_gmt":"2023-06-30T16:45:31","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/07\/01\/monthly-updates-2023-06\/"},"modified":"2025-01-03T18:47:52","modified_gmt":"2025-01-03T10:47:52","slug":"monthly-updates-2023-06","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/07\/01\/monthly-updates-2023-06\/","title":{"rendered":"Monthly Updates 2023.06"},"content":{"rendered":"
\n
\n
\n
\n
\n
\n
\n

01<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Cell. 20230609<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs<\/strong><\/p>\n

DNA\u4f4e\u7532\u57fa\u5316\u5bfc\u81f4\u65e9\u671f\u524d\u5217\u817a\u764c\u548cCTC\u4e2d\u7684\u6297\u80bf\u7624\u514d\u75ab\u57fa\u56e0\u6c89\u9ed8<\/strong><\/span><\/p>\n

Cell. 2023 Jun 9;S0092-8674(23)00580-9.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.05.028.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37327786\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u75c7\u901a\u5e38\u8868\u73b0\u4e3a\u5927\u91cf\u67d3\u8272\u8d28\u533a\u57df\u4f4e\u7532\u57fa\u5316\u5f15\u8d77\u7684\u57fa\u56e0\u6c89\u9ed8\uff0c\u4f46\u8fd9\u4e9b\u6c89\u9ed8\u5bf9\u80bf\u7624\u53d1\u751f\u7684\u4f5c\u7528\u4ecd\u4e0d\u786e\u5b9a\u3002\u901a\u8fc7\u9ad8\u5206\u8fa8\u7387\u5168\u57fa\u56e0\u7ec4\u5355\u7ec6\u80deDNA\u7532\u57fa\u5316\u6d4b\u5e8f\uff0c\u6211\u4eec\u53d1\u73b040\u4e2a\u6838\u5fc3\u4f4e\u7532\u57fa\u5316\u533a\u57df\u5728\u524d\u5217\u817a\u6076\u6027\u80bf\u7624\u6700\u65e9\u53ef\u68c0\u6d4b\u9636\u6bb5\u5230CTC\u4e2d\u5747\u5b58\u5728\u3002\u5728\u8fd9\u4e9b\u6291\u5236\u6027\u533a\u57df\u4e2d\uff0c\u6709\u4e9b\u7532\u57fa\u5316\u4f4d\u70b9\u9003\u907f\u6c89\u9ed8\uff0c\u5bcc\u96c6\u7ec6\u80de\u589e\u6b96\u76f8\u5173\u57fa\u56e0\u3002\u6838\u5fc3\u4f4e\u7532\u57fa\u5316\u533a\u57df\u5185\u8f6c\u5f55\u6c89\u9ed8\u7684\u57fa\u56e0\u5bcc\u96c6\u4e86\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u3002\u5176\u4e2d\u6700\u7a81\u51fa\u7684\u662f\u4e00\u4e2a\u5305\u542b\u4e94\u4e2aCD1\u57fa\u56e0\u7684\u5355\u4e2a\u57fa\u56e0\u7c07\uff0c\u8fd9\u4e9b\u57fa\u56e0\u5411NKT\u7ec6\u80de\u5448\u9012\u8102\u8d28\u6297\u539f\uff0c\u4ee5\u53ca\u56db\u4e2a\u4e0eIFI16\u76f8\u5173\u7684\u5e72\u6270\u7d20\u8bf1\u5bfc\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4e0e\u5148\u5929\u514d\u75ab\u6709\u5173\u3002\u5728\u514d\u75ab\u80fd\u529b\u6b63\u5e38\u7684\u5c0f\u9f20\u4e2d\u91cd\u65b0\u8868\u8fbeCD1\u6216IFI16\u5c0f\u9f20\u540c\u6e90\u57fa\u56e0\uff0c\u53ef\u6291\u5236\u80bf\u7624\u53d1\u751f\uff0c\u5e76\u4f34\u968f\u7740\u6297\u80bf\u7624\u514d\u75ab\u7684\u6fc0\u6d3b\u3002\u56e0\u6b64\uff0c\u65e9\u671f\u7684\u8868\u89c2\u9057\u4f20\u53d8\u5316\u53ef\u80fd\u4f1a\u5f71\u54cd\u80bf\u7624\u53d1\u751f\uff0c\u8fd9\u4e9b\u53d8\u5316\u9776\u5411\u7279\u5b9a\u67d3\u8272\u4f53\u4f4d\u70b9\u4e0a\u7684\u540c\u4f4d\u57fa\u56e0\u3002\u5728\u5bcc\u96c6CTC\u7684\u8840\u6db2\u6837\u672c\u4e2d\u53ef\u4ee5\u68c0\u6d4b\u5230\u4f4e\u7532\u57fa\u5316\u533a\u57df\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CD1A\uff1bDNA\u4f4e\u7532\u57fa\u5316\uff1bIFI16\uff1bNKT\u7ec6\u80de\uff1b\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff1b\u514d\u75ab\u76d1\u89c6\uff1b\u8102\u8d28\u6297\u539f\uff1b\u524d\u5217\u817a\u764c\uff1b\u5355\u7ec6\u80de\u6d4b\u5e8f\uff1b\u80bf\u7624\u53d1\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

02<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Cancer Cell. 20230605<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity<\/strong><\/p>\n

CMTM6\u901a\u8fc7\u8c03\u63a7CD58-CD2\u8f74\u4e0ePD-L1\u5f71\u54cd\u6297\u80bf\u7624\u514d\u75ab<\/strong><\/span><\/p>\n

Cancer Cell. 2023 Jun 5;S1535-6108(23)00181-2.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.ccell.2023.05.014.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37327789\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5728\u764c\u75c7\u514d\u75ab\u9003\u907f\u4e2d\uff0c\u514d\u75ab\u6291\u5236\u548c\u514d\u75ab\u6fc0\u6d3b\u4fe1\u53f7\u7684\u7ec6\u80de\u81ea\u4e3b\u5e73\u8861\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u901a\u8fc7\u4f7f\u7528\u60a3\u8005\u6765\u6e90\u7684\u5171\u57f9\u517b\u7269\u3001\u4eba\u6e90\u5316\u5c0f\u9f20\u6a21\u578b\u4ee5\u53ca\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u524d\u540e\u6d3b\u68c0\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7ec4\u7ec7\u7684\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u6211\u4eec\u53d1\u73b0\u764c\u7ec6\u80de\u5185\u6e90\u6027\u5b8c\u6574\u8868\u8fbe\u7684CD58\u53ca\u4e0eCD2\u7684\u7ed3\u5408\u5bf9\u4e8e\u6297\u80bf\u7624\u514d\u75ab\u81f3\u5173\u91cd\u8981\uff0c\u5e76\u53ef\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u3002\u8fd9\u4e00\u8f74\u7ebf\u7684\u7f3a\u9677\u901a\u8fc7\u51cf\u5f31T\u7ec6\u80de\u6fc0\u6d3b\u3001\u635f\u5bb3\u80bf\u7624\u5185T\u7ec6\u80de\u6d78\u6da6\u548c\u589e\u6b96\uff0c\u4ee5\u53ca\u589e\u52a0PD-L1\u86cb\u767d\u7a33\u5b9a\u6027\uff0c\u4fc3\u8fdb\u514d\u75ab\u9003\u907f\u3002\u901a\u8fc7CRISPR-Cas9\u548c\u86cb\u767d\u8d28\u7ec4\u5b66\u7b5b\u9009\uff0c\u6211\u4eec\u53d1\u73b0\u5e76\u9a8c\u8bc1\u4e86CMTM6\u5bf9CD58\u7a33\u5b9a\u6027\u548c\u5728CD58\u4e22\u5931\u65f6PD-L1\u4e0a\u8c03\u7684\u5173\u952e\u4f5c\u7528\u3002CD58\u548cPD-L1\u4e4b\u95f4\u4e89\u593a\u4e0eCMTM6\u7684\u7ed3\u5408\uff0c\u51b3\u5b9a\u4e86\u5b83\u4eec\u5728\u5185\u8d28\u7f51\u56de\u6536\u548c\u6eb6\u9176\u4f53\u964d\u89e3\u8fc7\u7a0b\u4e2d\u7684\u901f\u7387\u3002\u603b\u7684\u6765\u8bf4\uff0c\u6211\u4eec\u63cf\u8ff0\u4e86\u4e00\u4e2a\u5728\u764c\u75c7\u514d\u75ab\u4e2d\u975e\u5e38\u5173\u952e\u4f46\u5c1a\u672a\u53d7\u5230\u8db3\u591f\u91cd\u89c6\u7684\u8f74\u7ebf\uff0c\u5e76\u4e3a\u764c\u7ec6\u80de\u5982\u4f55\u5e73\u8861\u514d\u75ab\u6291\u5236\u548c\u514d\u75ab\u6fc0\u6d3b\u4fe1\u53f7\u63d0\u4f9b\u4e86\u5206\u5b50\u4f9d\u636e\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

CD2\uff1bCD58\uff1bCRISPR-Cas9\u7b5b\u9009\uff1bPDL1\uff1b\u5171\u6291\u5236\/\u5171\u523a\u6fc0\u5e73\u8861\uff1b\u764c\u75c7\u514d\u75ab\u9003\u907f\uff1b\u764c\u75c7\u514d\u75ab\u5b66\uff1b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff1b\u8d28\u8c31\u7b5b\u9009\uff1b\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u62b5\u6297\uff1b\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

03<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Nat Rev Clin Oncol. 20230616<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Antigen presentation in cancer – mechanisms and clinical implications for immunotherapy<\/strong><\/p>\n

\u80bf\u7624\u6297\u539f\u5448\u9012\u7684\u673a\u5236\u53ca\u5176\u5bf9\u4e34\u5e8a\u514d\u75ab\u6cbb\u7597\u7684\u5f71\u54cd<\/strong><\/span><\/p>\n

Nat Rev Clin Oncol. 2023 Jun 16.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41571-023-00789-4.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37328642\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u6709\u6548\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u7684\u51fa\u73b0\u5f7b\u5e95\u6539\u53d8\u4e86\u8bb8\u591a\u7c7b\u578b\u764c\u75c7\u7684\u4e34\u5e8a\u6cbb\u7597\u3002\u7136\u800c\uff0c\u53ea\u6709\u90e8\u5206\u63a5\u53d7\u8fd9\u4e9b\u6cbb\u7597\u7684\u60a3\u8005\u80fd\u591f\u5b9e\u73b0\u957f\u671f\u6301\u4e45\u7684\u80bf\u7624\u63a7\u5236\u3002\u56e0\u6b64\uff0c\u4e86\u89e3\u4e34\u5e8a\u53cd\u5e94\u548c\u5bf9\u6cbb\u7597\u7684\u62b5\u6297\u6027\u7684\u673a\u5236\u5bf9\u4e8e\u6269\u5927\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u6548\u679c\u81f3\u5173\u91cd\u8981\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u63cf\u8ff0\u4e86\u80bf\u7624\u4e2d\u6297\u539f\u52a0\u5de5\u548c\u5448\u9012\u7684\u5206\u5b50\u673a\u5236\u53ca\u5176\u4e34\u5e8a\u540e\u679c\u3002\u6211\u4eec\u7814\u7a76\u4e86\u6297\u539f\u5448\u9012\u673a\u5236\uff08APM\uff09\u7684\u5404\u4e2a\u65b9\u9762\u5982\u4f55\u5851\u9020\u80bf\u7624\u514d\u75ab\u3002\u7279\u522b\u662f\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86HLA\u7b49\u4f4d\u57fa\u56e0\u548c\u5176\u4ed6APM\u7ec4\u5206\u7684\u57fa\u56e0\u7ec4\u53d8\u5f02\uff0c\u5f3a\u8c03\u5b83\u4eec\u5bf9\u6076\u6027\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u514d\u75ab\u80bd\u7ec4\u7684\u5f71\u54cd\u3002\u4e86\u89e3APM\u53ca\u5176\u8c03\u63a7\u65b9\u5f0f\uff0c\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u53d8\u5316\u5bf9\u4e8e\u5224\u65ad\u60a3\u8005\u662f\u5426\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u53cd\u5e94\u4ee5\u53ca\u4e3a\u4ec0\u4e48\u6709\u4e9b\u60a3\u8005\u4f1a\u4ea7\u751f\u6297\u836f\u6027\u81f3\u5173\u91cd\u8981\u3002\u6211\u4eec\u5173\u6ce8\u4e86\u6700\u8fd1\u53d1\u73b0\u7684\u5f71\u54cd\u63a5\u53d7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u60a3\u8005\u4e34\u5e8a\u7ed3\u5c40\u7684\u5206\u5b50\u548c\u57fa\u56e0\u7ec4\u6539\u53d8\u3002\u5bf9\u8fd9\u4e9b\u53d8\u91cf\u5982\u4f55\u4ecb\u5bfc\u80bf\u7624-\u514d\u75ab\u76f8\u4e92\u4f5c\u7528\u7684\u6df1\u5165\u4e86\u89e3\u5c06\u6307\u5bfc\u514d\u75ab\u6cbb\u7597\u7684\u66f4\u7cbe\u786e\u5e94\u7528\uff0c\u5e76\u63ed\u793a\u65b0\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u7684\u6f5c\u5728\u53d1\u5c55\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

04<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Dev Cell. 20230619<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies<\/strong><\/p>\n

\u7ec6\u80de\u8870\u8001\u91cd\u5851\u80bf\u7624\u5fae\u73af\u5883\uff1a\u8870\u8001\u6cbb\u7597\u7684\u673a\u9047<\/strong><\/span><\/p>\n

Dev Cell. 2023 Jun 19;58(12):1007-1021.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.devcel.2023.05.010.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37339603\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7ec6\u80de\u8870\u8001\u662f\u4e0e\u8870\u8001\u548c\u75be\u75c5\uff08\u5305\u62ec\u764c\u75c7\uff09\u76f8\u5173\u7684\u4e00\u79cd\u5e94\u6fc0\u53cd\u5e94\u3002\u8870\u8001\u7ec6\u80de\u7ecf\u5386\u7a33\u5b9a\u7684\u7ec6\u80de\u5468\u671f\u505c\u6ede\uff0c\u53d1\u751f\u5f62\u6001\u548c\u4ee3\u8c22\u91cd\u7f16\u7a0b\u7684\u6539\u53d8\uff0c\u5e76\u4ea7\u751f\u4e00\u79cd\u540d\u4e3a\u8870\u8001\u76f8\u5173\u5206\u6ccc\u8868\u578b\uff08SASP\uff09\u7684\u751f\u7269\u6d3b\u6027\u5206\u6ccc\u7269\u3002\u5728\u764c\u75c7\u4e2d\uff0c\u8870\u8001\u662f\u80bf\u7624\u8fdb\u5c55\u7684\u91cd\u8981\u969c\u788d\u3002\u5728\u764c\u524d\u7ec6\u80de\u4e2d\u8bf1\u5bfc\u8870\u8001\u53ef\u4ee5\u9650\u5236\u764c\u75c7\u7684\u53d1\u751f\uff0c\u8bb8\u591a\u764c\u75c7\u6cbb\u7597\u624b\u6bb5\u90e8\u5206\u901a\u8fc7\u8bf1\u5bfc\u764c\u7ec6\u80de\u8870\u8001\u6765\u53d1\u6325\u4f5c\u7528\u3002\u7136\u800c\uff0c\u77db\u76fe\u7684\u662f\uff0c\u6ede\u7559\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u8870\u8001\u7ec6\u80de\u53ef\u80fd\u4fc3\u4f7f\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u6cbb\u7597\u8010\u53d7\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u5b58\u5728\u4e8eTME\u4e2d\u7684\u4e0d\u540c\u7c7b\u578b\u7684\u8870\u8001\u7ec6\u80de\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u8870\u8001\u7ec6\u80de\u53ca\u5176SASP\u5982\u4f55\u91cd\u5851TME\u3001\u5f71\u54cd\u514d\u75ab\u53cd\u5e94\uff0c\u5e76\u5f71\u54cd\u764c\u75c7\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5f3a\u8c03\u4e86\u8870\u8001\u6cbb\u7597\u7684\u91cd\u8981\u6027\uff0c\u5305\u62ec\u901a\u8fc7\u6062\u590d\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548c\u5f71\u54cdTME\u6765\u6d88\u9664\u8870\u8001\u7ec6\u80de\uff0c\u5e76\u963b\u6b62\u80bf\u7624\u8fdb\u5c55\u548c\u8f6c\u79fb\u7684\u8870\u8001\u7ec6\u80de\u6e05\u9664\u5242\u7684\u4f7f\u7528\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

SASP\uff1bTME\uff1b\u764c\u75c7\uff1b\u8870\u8001\uff1b\u8870\u8001\u76f8\u5173\u5206\u6ccc\u8868\u578b\uff1b\u8870\u8001\u7ec6\u80de\u6e05\u9664\u5242\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

05<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Nat Rev Drug Discov. 20230621<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Trends in the approval of cancer therapies by the FDA in the twenty-first century<\/strong><\/p>\n

21\u4e16\u7eaaFDA\u6279\u51c6\u7684\u764c\u75c7\u7597\u6cd5\u7684\u8d8b\u52bf<\/strong><\/span><\/p>\n

Nat Rev Drug Discov. 2023 Jun 21.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41573-023-00723-4.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37344568\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u81ea\u4e16\u7eaa\u4e4b\u4ea4\u4ee5\u6765\uff0c\u764c\u75c7\u6cbb\u7597\u9886\u57df\u53d1\u751f\u4e86\u5de8\u5927\u53d8\u9769\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u4e86\u663e\u8457\u7684\u7597\u6548\u6539\u5584\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u603b\u7ed3\u4e862000\u5e741\u6708\u81f32022\u5e7410\u6708\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7684\u80bf\u7624\u6cbb\u7597\u4ea7\u54c1\u7684\u8d8b\u52bf\uff0c\u5e76\u628a\u8fd9\u4e9b\u4ea7\u54c1\u6839\u636e\u5176\u4f5c\u7528\u673a\u5236\u548c\u4e3b\u8981\u9776\u6807\u8fdb\u884c\u5206\u7c7b\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u6b64\u671f\u95f4\uff0c\u80bf\u7624\u9002\u5e94\u75c7\u6279\u51c6\u7684\u901f\u5ea6\u6709\u6240\u63d0\u9ad8\uff0c\u8fd9\u4e3b\u8981\u53d7\u5230\u9776\u5411\u6cbb\u7597\u6279\u51c6\u7684\u63a8\u52a8\uff0c\u540c\u65f6\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u7684\u63a8\u5e7f\u901f\u5ea6\u4e5f\u6709\u6240\u63d0\u9ad8\u3002\u5728\u6279\u51c6\u4ea7\u54c1\u548c\u9002\u5e94\u75c7\u7684\u6570\u91cf\u4e0a\uff0c\u6fc0\u9176\u6291\u5236\u5242\u662f\u5360\u4e3b\u5bfc\u5730\u4f4d\u7684\u4ea7\u54c1\u7c7b\u522b\uff0c\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u76f4\u52302011\u5e74\u624d\u8fdb\u5165\u5e02\u573a\uff0c\u4f46\u5df2\u7ecf\u62e5\u6709\u7b2c\u4e8c\u591a\u7684\u6279\u51c6\u3002\u6b64\u5916\uff0c\u80bf\u7624\u90e8\u4f4d\u4e0d\u76f8\u5173\u7684\u6279\u51c6\u7684\u51fa\u73b0\u548c\u751f\u7269\u6807\u5fd7\u7269\u786e\u5b9a\u7684\u4eba\u7fa4\u5728\u6279\u51c6\u4efd\u989d\u4e2d\u7684\u6bd4\u4f8b\u7565\u6709\u589e\u52a0\u3002\u6700\u540e\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u8fd9\u4e9b\u8d8b\u52bf\u5bf9\u80bf\u7624\u6cbb\u7597\u4ea7\u54c1\u672a\u6765\u5f00\u53d1\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u548c\u6280\u672f\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

06<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Protein Cell. 20230622<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids<\/strong><\/p>\n

\u57fa\u4e8e\u4eba\u7c7b\u7ed3\u76f4\u80a0\u764c\u7c7b\u5668\u5b98\u7684\u836f\u7269\u518d\u5229\u7528\u7b5b\u9009\u53ca\u673a\u5236\u5206\u6790<\/strong><\/span><\/p>\n

Protein Cell. 2023 Jun 22;pwad038.<\/em><\/p>\n

doi: <\/strong>10.1093\/procel\/pwad038.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37345888\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u662f\u4e00\u79cd\u9ad8\u5ea6\u5f02\u8d28\u6027\u7684\u764c\u75c7\uff0c\u63a2\u7d22\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u662f\u4e00\u4e2a\u4e9f\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u5efa\u7acb\u4e86\u6e90\u4e8e\u4eba\u7c7bCRC\u80bf\u7624\u7684\u7c7b\u5668\u5b98\uff0c\u8fd9\u4e9b\u7c7b\u5668\u5b98\u5f88\u597d\u5730\u4ee3\u8868\u4e86\u539f\u53d1\u80bf\u7624\u7684\u5f62\u6001\u548c\u5206\u5b50\u5f02\u8d28\u6027\u3002\u4e3a\u4e86\u6709\u6548\u5730\u8bc6\u522b\u7ed3\u76f4\u80a0\u764c\u7684\u518d\u5229\u7528\u836f\u7269\uff0c\u6211\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u7a33\u5b9a\u7684\u57fa\u4e8e\u7c7b\u5668\u5b98\u7684\u836f\u7269\u7b5b\u9009\u7cfb\u7edf\u3002\u901a\u8fc7\u7ed3\u5408\u518d\u5229\u7528\u836f\u7269\u5e93\u548c\u57fa\u4e8e\u8ba1\u7b97\u7684\u836f\u7269\u9884\u6d4b\uff0c\u6211\u4eec\u6d4b\u8bd5\u4e86335\u79cd\u836f\u7269\uff0c\u5e76\u786e\u5b9a\u4e8634\u79cd\u5177\u6709\u6297CRC\u4f5c\u7528\u7684\u836f\u7269\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u6211\u4eec\u5bf9\u836f\u7269\u53cd\u5e94\u7684\u8f6c\u5f55\u7ec4\u8fdb\u884c\u4e86\u8be6\u7ec6\u7684\u5206\u6790\uff0c\u5e76\u5c06\u836f\u7269\u53cd\u5e94\u7279\u5f81\u5206\u4e3a\u4e94\u79cd\u4ee3\u8868\u6027\u6a21\u5f0f\uff1a\u8bf1\u5bfc\u5206\u5316\u3001\u751f\u957f\u6291\u5236\u3001\u4ee3\u8c22\u6291\u5236\u3001\u514d\u75ab\u53cd\u5e94\u4fc3\u8fdb\u548c\u7ec6\u80de\u5468\u671f\u6291\u5236\u3002\u5728\u4f53\u5185\u5efa\u7acb\u7684\u60a3\u8005\u6e90\u7c7b\u5668\u5b98\u5f02\u79cd\u79fb\u690d\uff08PDOX\uff09\u7cfb\u7edf\u4e2d\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u5019\u9009\u836f\u7269\u7684\u6297\u764c\u6d3b\u6027\u3002\u6211\u4eec\u53d1\u73b0\uff0cfedratinib\u3001trametinib\u548cbortezomib\u8868\u73b0\u51fa\u6709\u6548\u7684\u6297\u764c\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u8bc4\u4f30\u4e86\u4f53\u5916\u7c7b\u5668\u5b98\u548c\u6210\u5bf9PDOX\u4e4b\u95f4\u836f\u7269\u53cd\u5e94\u7279\u5f81\u7684\u4e00\u81f4\u6027\u548c\u4e0d\u4e00\u81f4\u6027\u3002\u6211\u4eec\u7684\u7814\u7a76\u4e3a\u836f\u7269\u53d1\u73b0\u63d0\u4f9b\u4e86\u4e00\u79cd\u521b\u65b0\u9014\u5f84\uff0c\u836f\u7269\u53cd\u5e94\u7684\u4ee3\u8868\u6027\u8f6c\u5f55\u7ec4\u7279\u5f81\u4e3a\u5f00\u53d1\u7ed3\u76f4\u80a0\u764c\u7684\u65b0\u578b\u4e34\u5e8a\u6cbb\u7597\u65b9\u6cd5\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u8d44\u6e90\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u7ed3\u76f4\u80a0\u764c\uff1b\u836f\u7269\u518d\u5229\u7528\uff1b\u4f5c\u7528\u673a\u5236\uff1b\u7c7b\u5668\u5b98\uff1b\u60a3\u8005\u6765\u6e90\u7684\u7c7b\u5668\u5b98\u5f02\u79cd\u79fb\u690d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

07<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Immunity. 20230613<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses<\/strong><\/p>\n

\u80bf\u7624\u6765\u6e90\u7684\u524d\u5217\u817a\u7d20E2\u5bfc\u81f4cDC1\u529f\u80fd\u969c\u788d\u4ece\u800c\u635f\u5bb3\u4e86\u80bf\u7624\u5185\u7684T\u7ec6\u80de\u5e94\u7b54<\/strong><\/span><\/p>\n

Immunity. 2023 Jun 13;56(6):1341-1358.e11.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.immuni.2023.05.011.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37315536\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

1\u578b\u7ecf\u5178\u6811\u7a81\u72b6\u7ec6\u80de\uff08cDC1s\uff09\u5728\u6297\u764c\u514d\u75ab\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76ee\u524d\u8ba4\u4e3a\uff0c\u4fdd\u62a4\u6027\u7684\u6297\u764c\u514d\u75ab\u9700\u8981cDC1\u7ef4\u6301\u80bf\u7624\u5185\u7684T\u7ec6\u80de\u5e94\u7b54\uff0c\u4f46\u8fd9\u4e00\u529f\u80fd\u7684\u8c03\u63a7\u53ca\u5176\u88ab\u98a0\u8986\u662f\u5426\u6709\u52a9\u4e8e\u514d\u75ab\u9003\u907f\u5c1a\u4e0d\u6e05\u695a\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\u80bf\u7624\u6765\u6e90\u7684\u524d\u5217\u817a\u7d20E2\uff08PGE2\uff09\u80fd\u7f16\u7a0b\u51facDC1\u7684\u529f\u80fd\u969c\u788d\u72b6\u6001\uff0c\u7834\u574f\u4e86\u5b83\u4eec\u5728\u5c40\u90e8\u6fc0\u6d3b\u6297\u764cCD8+ T\u7ec6\u80de\u5e94\u7b54\u7684\u80fd\u529b\u3002\u5177\u4f53\u673a\u5236\u4e0a\uff0cPGE2\u53d7\u4f53EP2\u548cEP4\u901a\u8fc7cAMP\u4fe1\u53f7\u4ecb\u5bfc\u4e86cDC1\u7684\u529f\u80fd\u969c\u788d\uff0c\u8fd9\u53d6\u51b3\u4e8e\u8f6c\u5f55\u56e0\u5b50IRF8\u7684\u4e27\u5931\u3002\u963b\u65adPGE2-EP2\/EP4-cDC1\u8f74\u53ef\u9632\u6b62\u80bf\u7624\u4e2dcDC1\u529f\u80fd\u969c\u788d\uff0c\u5c40\u90e8\u6062\u590d\u6297\u764cCD8+ T\u7ec6\u80de\u5e94\u7b54\uff0c\u5e76\u5b9e\u73b0\u764c\u75c7\u514d\u75ab\u63a7\u5236\u3002\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u53d1\u73b0\u5728\u4eba\u7c7bcDC1\u4e2d\uff0cPGE2\u8bf1\u5bfc\u7684\u529f\u80fd\u969c\u788d\u662f\u4fdd\u5b88\u7684\uff0c\u5e76\u4e14\u4e0e\u764c\u75c7\u60a3\u8005\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86\u4e00\u4e2a\u4f9d\u8d56\u4e8ecDC1\u7684\u6297\u764c\u514d\u75ab\u80bf\u7624\u5185\u68c0\u67e5\u70b9\uff0c\u8be5\u68c0\u67e5\u70b9\u901a\u8fc7PGE2\u8fdb\u884c\u514d\u75ab\u9003\u907f\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

T\u7ec6\u80de\uff1b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\uff1b\u6811\u7a81\u72b6\u7ec6\u80de\uff1b\u514d\u75ab\u9003\u907f\uff1b\u524d\u5217\u817a\u7d20E2\uff1b\u80bf\u7624\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

08<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Nature. 20230614-1<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours<\/strong><\/p>\n

CD4+ T\u7ec6\u80de\u8bf1\u5bfc\u7684\u708e\u75c7\u6027\u7ec6\u80de\u6b7b\u4ea1\u63a7\u5236\u514d\u75ab\u9003\u907f\u80bf\u7624<\/strong><\/span><\/p>\n

Nature. 2023 Jun 14.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-06199-x.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37316667\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u5927\u591a\u6570\u4e34\u5e8a\u5e94\u7528\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4f9d\u8d56\u4e8eCD8+\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u76f4\u63a5\u8bc6\u522b\u548c\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7b56\u7565\u53d7\u5230\u4e3b\u8981\u7ec4\u7ec7\u517c\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09\u7f3a\u9677\u80bf\u7624\u7ec6\u80de\u7684\u51fa\u73b0\u548c\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u5f62\u6210\u7684\u9650\u5236\u3002\u8fd1\u5e74\u6765\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0cCD4+\u6548\u5e94\u7ec6\u80de\u5728\u72ec\u7acb\u4e8eCD8+ T\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\u4e5f\u80fd\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u4f5c\u51fa\u8d21\u732e\uff0c\u4f46\u662f\u5982\u4f55\u91ca\u653e\u5176\u5168\u90e8\u6f5c\u529b\u7684\u7b56\u7565\u5c1a\u6709\u5f85\u786e\u5b9a\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u63cf\u8ff0\u4e86\u4e00\u79cd\u673a\u5236\uff0c\u5373\u5c11\u91cfCD4+ T\u7ec6\u80de\u8db3\u4ee5\u6d88\u9664\u9003\u8131\u4e86CD8+ T\u7ec6\u80de\u6740\u4f24\u7684MHC\u7f3a\u9677\u80bf\u7624\u3002\u6211\u4eec\u53d1\u73b0\uff0cCD4+\u6548\u5e94T\u7ec6\u80de\u4f18\u5148\u805a\u96c6\u5728\u80bf\u7624\u4fb5\u88ad\u8fb9\u7f18\uff0c\u4e0eMHC-II+CD11c+\u6297\u539f\u5448\u9012\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u30021\u578b\u8f85\u52a9T\u7ec6\u80de\u5b9a\u5411\u7684CD4+ T\u7ec6\u80de\u548c\u5148\u5929\u514d\u75ab\u523a\u6fc0\u4f7f\u80bf\u7624\u76f8\u5173\u7684\u9ad3\u7cfb\u7ec6\u80de\u7f51\u7edc\u91cd\u7f16\u7a0b\u4e3a\u5e72\u6270\u7d20\u6fc0\u6d3b\u7684\u6297\u539f\u5448\u9012\u548ciNOS\u8868\u8fbe\u7684\u80bf\u7624\u6740\u4f24\u6548\u5e94\u8868\u578b\u3002\u603b\u4e4b\uff0cCD4+ T\u7ec6\u80de\u548c\u80bf\u7624\u6740\u4f24\u6027\u9ad3\u7cfb\u7ec6\u80de\u534f\u540c\u8bf1\u5bfc\u8fdc\u7aef\u7684\u708e\u75c7\u6027\u7ec6\u80de\u6b7b\u4ea1\uff0c\u95f4\u63a5\u6d88\u9664\u4e86\u5e72\u6270\u7d20\u4e0d\u5e94\u7b54\u548cMHC\u7f3a\u9677\u80bf\u7624\u3002\u8fd9\u4e9b\u7ed3\u679c\u8bc1\u660e\u4e86CD4+ T\u7ec6\u80de\u548c\u5148\u5929\u514d\u75ab\u523a\u6fc0\u5242\u5728\u4e34\u5e8a\u4e0a\u5177\u6709\u5f00\u53d1\u6f5c\u529b\uff0c\u4f5c\u4e3a\u4e00\u79cd\u8865\u5145CD8+ T\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u76f4\u63a5\u7ec6\u80de\u6bd2\u6d3b\u6027\u7684\u7b56\u7565\uff0c\u63a8\u8fdb\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

09<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Nature. 20230614-2<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

The neuroscience of cancer<\/strong><\/p>\n

\u764c\u75c7\u7684\u795e\u7ecf\u79d1\u5b66<\/strong><\/span><\/p>\n

Nature. 2023 Jun;618(7965):467-479.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41586-023-05968-y.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37316719\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u795e\u7ecf\u7cfb\u7edf\u5728\u6574\u4e2a\u751f\u547d\u5468\u671f\u4e2d\u8c03\u63a7\u7ec4\u7ec7\u5e72\u7ec6\u80de\u548c\u524d\u4f53\u7ec6\u80de\u7fa4\u3002\u7c7b\u4f3c\u4e8e\u5176\u5728\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\uff0c\u795e\u7ecf\u7cfb\u7edf\u6b63\u5728\u9010\u6e10\u6210\u4e3a\u764c\u75c7\u7684\u5173\u952e\u8c03\u63a7\u56e0\u7d20\uff0c\u4ece\u80bf\u7624\u53d1\u751f\u5230\u6076\u6027\u751f\u957f\u548c\u8f6c\u79fb\u6269\u6563\u3002\u5404\u79cd\u4e34\u5e8a\u524d\u6a21\u578b\u5728\u4e00\u7cfb\u5217\u6076\u6027\u80bf\u7624\u4e2d\u8868\u660e\uff0c\u795e\u7ecf\u7cfb\u7edf\u6d3b\u52a8\u53ef\u4ee5\u63a7\u5236\u764c\u75c7\u7684\u53d1\u751f\uff0c\u5e76\u5bf9\u764c\u75c7\u7684\u8fdb\u5c55\u548c\u8f6c\u79fb\u4ea7\u751f\u5f3a\u5927\u5f71\u54cd\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u764c\u75c7\u4e5f\u4f1a\u91cd\u5851\u548c\u52ab\u6301\u795e\u7ecf\u7cfb\u7edf\u7684\u7ed3\u6784\u548c\u529f\u80fd\u3002\u8fd9\u79cd\u795e\u7ecf\u7cfb\u7edf\u548c\u764c\u75c7\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u65e2\u53d1\u751f\u5728\u5c40\u90e8\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u4e5f\u53d1\u751f\u5728\u5168\u8eab\u8303\u56f4\u5185\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u795e\u7ecf\u5143\u548c\u80f6\u8d28\u7ec6\u80de\u80fd\u591f\u901a\u8fc7\u65c1\u5206\u6ccc\u56e0\u5b50\u4e0e\u6076\u6027\u7ec6\u80de\u76f4\u63a5\u4ea4\u6d41\uff0c\u67d0\u4e9b\u60c5\u51b5\u4e0b\u8fd8\u80fd\u901a\u8fc7\u795e\u7ecf\u5143\u548c\u764c\u7ec6\u80de\u8fdb\u884c\u7a81\u89e6\u4ea4\u6d41\u3002\u6b64\u5916\uff0c\u95f4\u63a5\u76f8\u4e92\u4f5c\u7528\u901a\u8fc7\u5faa\u73af\u4fe1\u53f7\u4ee5\u53ca\u5bf9\u514d\u75ab\u7ec6\u80de\u8fc1\u79fb\u548c\u529f\u80fd\u7684\u5f71\u54cd\u5728\u8fdc\u5904\u53d1\u751f\u3002\u8fd9\u79cd\u5728\u795e\u7ecf\u7cfb\u7edf\u3001\u514d\u75ab\u7cfb\u7edf\u548c\u764c\u75c7\u4e4b\u95f4\u7684\u4ea4\u6d41\uff08\u65e0\u8bba\u662f\u5728\u5168\u8eab\u8303\u56f4\u8fd8\u662f\u5c40\u90e8\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff09\u8c03\u8282\u4fc3\u80bf\u7624\u708e\u75c7\u548c\u6297\u764c\u514d\u75ab\u3002\u56e0\u6b64\uff0c\u9610\u660e\u764c\u75c7\u7684\u795e\u7ecf\u79d1\u5b66\u9700\u8981\u795e\u7ecf\u79d1\u5b66\u3001\u53d1\u80b2\u751f\u7269\u5b66\u3001\u514d\u75ab\u5b66\u548c\u764c\u75c7\u751f\u7269\u5b66\u7b49\u9886\u57df\u7684\u8de8\u5b66\u79d1\u5408\u4f5c\uff0c\u8fd9\u53ef\u80fd\u63a8\u8fdb\u8bb8\u591a\u6700\u96be\u6cbb\u7597\u7684\u6076\u6027\u80bf\u7624\u7684\u6709\u6548\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

10<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

J Clin Invest. 20230615<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions<\/strong><\/p>\n

\u81ea\u4e3bIL-36R\u4fe1\u53f7\u5728\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\u6fc0\u6d3b\u5f3a\u5927\u7684\u6297\u80bf\u7624\u6548\u5e94\u529f\u80fd<\/strong><\/span><\/p>\n

J Clin Invest. 2023 Jun 15;133(12):e162088.<\/em><\/p>\n

doi: <\/strong>10.1172\/JCI162088.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37317970\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u867d\u7136\u514d\u75ab\u7597\u6cd5\u7684\u5feb\u901f\u53d1\u5c55\u5df2\u7ecf\u5f7b\u5e95\u6539\u53d8\u4e86\u764c\u75c7\u6cbb\u7597\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u60a3\u8005\u80fd\u591f\u4ece\u4e2d\u83b7\u5f97\u4e34\u5e8a\u76ca\u5904\u3002\u6d88\u9664\u8f83\u5927\u7684\u3001\u5df2\u5efa\u7acb\u7684\u80bf\u7624\u4f3c\u4e4e\u4f9d\u8d56\u4e8e\u6fc0\u6d3b\u548c\u8c03\u52a8\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7ec4\u4ef6\uff0c\u4ee5\u4ea7\u751f\u5f3a\u70c8\u548c\u5168\u9762\u7684\u514d\u75ab\u5e94\u7b54\u3002\u56e0\u6b64\uff0c\u5bfb\u627e\u8fd9\u7c7b\u836f\u7269\u662f\u4e00\u4e2a\u8feb\u5207\u7684\u533b\u7597\u9700\u6c42\uff0c\u56e0\u4e3a\u5b83\u4eec\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u4e2d\u975e\u5e38\u7a00\u7f3a\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0IL-36\u7ec6\u80de\u56e0\u5b50\u53ef\u4ee5\u8c03\u52a8\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u529b\u91cf\uff0c\u91cd\u5851\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\uff0c\u5e76\u901a\u8fc7\u5bbf\u4e3b\u9020\u8840\u7ec6\u80de\u4e2d\u7684\u4fe1\u53f7\u4f20\u5bfc\u4ecb\u5bfc\u5f3a\u5927\u7684\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002IL-36\u4fe1\u53f7\u4ee5\u7ec6\u80de\u56fa\u6709\u7684\u65b9\u5f0f\u8c03\u8282\u4e2d\u6027\u7c92\u7ec6\u80de\uff0c\u4e0d\u4ec5\u6781\u5927\u5730\u589e\u5f3a\u4e86\u5b83\u4eec\u76f4\u63a5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u8fd8\u4fc3\u8fdb\u4e86T\u7ec6\u80de\u548cNK\u7ec6\u80de\u7684\u5e94\u7b54\u3002\u5c3d\u7ba1\u4e2d\u6027\u7c92\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u5bcc\u96c6\u901a\u5e38\u4e0e\u4e0d\u826f\u9884\u540e\u7ed3\u679c\u76f8\u5173\uff0c\u4f46\u6211\u4eec\u7684\u7ed3\u679c\u5f3a\u8c03\u4e86IL-36\u7684\u591a\u6548\u5e94\u548c\u6cbb\u7597\u6f5c\u529b\uff0c\u53ef\u5c06\u80bf\u7624\u6d78\u6da6\u4e2d\u6027\u7c92\u7ec6\u80de\u8f6c\u53d8\u4e3a\u5f3a\u5927\u7684\u6548\u5e94\u7ec6\u80de\uff0c\u5e76\u8c03\u52a8\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u4ee5\u5b9e\u73b0\u5b9e\u4f53\u80bf\u7624\u4e2d\u6301\u4e45\u7684\u6297\u80bf\u7624\u5e94\u7b54\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u7684\u7814\u7a76\u4e3a\u5f00\u53d1\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6709\u5e0c\u671b\u7684\u65b9\u5411\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u514d\u75ab\u5b66\uff1b\u514d\u75ab\u6cbb\u7597\uff1b\u5148\u5929\u514d\u75ab\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\uff1b\u80bf\u7624\u5b66\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

11<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Sci Transl Med. 20230607<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer<\/strong><\/p>\n

\u80bf\u7624\u76f8\u5173\u7ea4\u7ef4\u5316\u635f\u5bb3\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u514d\u75ab\u76d1\u89c6\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u53cd\u5e94<\/strong><\/span><\/p>\n

Sci Transl Med. 2023 Jun 7;15(699):eadh8005.<\/em><\/p>\n

doi: <\/strong>10.1126\/scitranslmed.adh8005.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37285399\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u662f\u5bfc\u81f4\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u5c3d\u7ba1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5df2\u7ecf\u63d0\u9ad8\u4e86\u8bb8\u591aNSCLC\u60a3\u8005\u7684\u751f\u5b58\u7387\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u672a\u80fd\u83b7\u5f97\u957f\u671f\u6548\u76ca\u3002\u4e86\u89e3\u5bfc\u81f4NSCLC\u514d\u75ab\u76d1\u89c6\u51cf\u5f31\u7684\u56e0\u7d20\u5bf9\u4e8e\u6539\u5584\u60a3\u8005\u9884\u540e\u81f3\u5173\u91cd\u8981\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\u4eba\u7c7bNSCLC\u4e2d\u542b\u6709\u5927\u91cf\u7ea4\u7ef4\u5316\uff0c\u8fd9\u4e0eT\u7ec6\u80de\u6d78\u6da6\u51cf\u5c11\u76f8\u5173\u3002\u5728\u5c0f\u9f20NSCLC\u6a21\u578b\u4e2d\uff0c\u7ea4\u7ef4\u5316\u7684\u8bf1\u5bfc\u5bfc\u81f4\u80ba\u764c\u8fdb\u5c55\u589e\u52a0\uff0cT\u7ec6\u80de\u514d\u75ab\u76d1\u89c6\u53d7\u635f\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u7684\u6548\u679c\u51cf\u5f31\u3002\u4e0e\u8fd9\u4e9b\u53d8\u5316\u76f8\u5173\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u7ea4\u7ef4\u5316\u5bfc\u81f4\u6570\u91cf\u548c\u529f\u80fd\u53d7\u635f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u4ee5\u53ca\u53ef\u80fd\u5bfc\u81f4\u514d\u75ab\u6291\u5236\u7684\u5de8\u566c\u7ec6\u80de\u8868\u578b\u6539\u53d8\u3002\u5728\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230Col13a1\u8868\u8fbe\u7fa4\u4f53\u7684\u72ec\u7279\u53d8\u5316\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4ea7\u751f\u8d8b\u5316\u56e0\u5b50\u62db\u52df\u5de8\u566c\u7ec6\u80de\u548c\u8c03\u8282\u6027T\u7ec6\u80de\uff0c\u540c\u65f6\u9650\u5236\u6811\u7a81\u72b6\u7ec6\u80de\u548cT\u7ec6\u80de\u7684\u62db\u52df\u3002\u901a\u8fc7\u9776\u5411\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u53d7\u4f53\u4fe1\u53f7\u6765\u6291\u5236\u7ea4\u7ef4\u5316\uff0c\u53ef\u4ee5\u589e\u5f3aT\u7ec6\u80de\u53cd\u5e94\u5e76\u6539\u5584\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u7597\u6548\uff0c\u4f46\u4ec5\u5728\u5316\u7597\u80cc\u666f\u4e0b\u5982\u6b64\u3002\u603b\u4e4b\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u5728NSCLC\u4e2d\uff0c\u7ea4\u7ef4\u5316\u5bfc\u81f4\u514d\u75ab\u76d1\u89c6\u51cf\u5c11\u548c\u5bf9\u68c0\u67e5\u70b9\u963b\u65ad\u53cd\u5e94\u4e0d\u4f73\uff0c\u5e76\u5f3a\u8c03\u6297\u7ea4\u7ef4\u5316\u7597\u6cd5\u4f5c\u4e3a\u514b\u670d\u514d\u75ab\u6cbb\u7597\u8010\u836f\u7684\u5019\u9009\u7b56\u7565\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5efa\u8bae\u5728NSCLC\u7684\u6cbb\u7597\u4e2d\uff0c\u5e94\u8be5\u8003\u8651\u4f7f\u7528\u9488\u5bf9\u7ea4\u7ef4\u5316\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u4ee5\u63d0\u9ad8\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u548c\u751f\u5b58\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

12<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Nat Commun. 20230608<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner<\/strong><\/p>\n

\u80bf\u7624\u81ea\u4e3b\u548c\u81ea\u5206\u6ccc\u65b9\u5f0f\u4e0b\u4ee3\u8c22\u9176CD73\u5bf9\u80f0\u817a\u764c\u514d\u75ab\u6291\u5236\u7684\u8f6c\u5f55\u8c03\u63a7<\/strong><\/span><\/p>\n

Nat Commun. 2023 Jun 8;14(1):3364.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41467-023-38578-3.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37291128\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u764c\u7ec6\u80de\u4ee3\u8c22\u6709\u52a9\u4e8e\u5efa\u7acb\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002\u7ec6\u80de\u8868\u9762CD73\u662fATP\u4ee3\u8c22\u4e2d\u7684\u5173\u952e\u9176\uff0c\u5176\u8868\u8fbe\u5f02\u5e38\u4f1a\u5bfc\u81f4\u7ec6\u80de\u5916\u817a\u82f7\u7684\u79ef\u7d2f\uff0c\u5bf9\u80bf\u7624\u6d78\u6da6\u7684\u6dcb\u5df4\u7ec6\u80de\u4f1a\u4ea7\u751f\u76f4\u63a5\u6291\u5236\u4f5c\u7528\u3002\u7136\u800c\uff0c\u6211\u4eec\u5bf9CD73\u5bf9\u80bf\u7624\u7ec6\u80de\u5185\u8d1f\u514d\u75ab\u8c03\u8282\u76f8\u5173\u4fe1\u53f7\u5206\u5b50\u548c\u8f6c\u5bfc\u9014\u5f84\u7684\u5f71\u54cd\u8fd8\u4e86\u89e3\u751a\u5c11\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u65e8\u5728\u63a2\u8ba8CD73\u5728\u80f0\u817a\u764c\u514d\u75ab\u6291\u5236\u4e2d\u7684\u591a\u529f\u80fd\u4f5c\u7528\u3002\u80f0\u817a\u764c\u662f\u4e00\u4e2a\u7406\u60f3\u7684\u6a21\u578b\uff0c\u56e0\u4e3a\u5b83\u5177\u6709\u764c\u75c7\u4ee3\u8c22\u3001\u514d\u75ab\u5fae\u73af\u5883\u548c\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u4e4b\u95f4\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u5728\u591a\u79cd\u80f0\u817a\u764c\u6a21\u578b\u4e2d\uff0cCD73\u7279\u5f02\u6027\u836f\u7269\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u8054\u5408\u5e94\u7528\u53ef\u4ee5\u8d77\u5230\u534f\u540c\u4f5c\u7528\u3002\u901a\u8fc7\u8d28\u8c31\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\uff0c\u6211\u4eec\u53d1\u73b0CD73\u6291\u5236\u5242\u51cf\u5c11\u4e86\u80f0\u817a\u764c\u4e2d\u80bf\u7624\u6d78\u6da6\u7684Tregs\u3002\u6211\u4eec\u8fd8\u53d1\u73b0\u80bf\u7624\u7ec6\u80de\u81ea\u4e3b\u8868\u8fbe\u7684CD73\u4fc3\u8fdb\u4e86Treg\u7684\u62db\u52df\u3002\u901a\u8fc7\u6574\u5408\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u8f6c\u5f55\u7ec4\u5b66\u5206\u6790\uff0c\u6211\u4eec\u786e\u5b9aCCL5\u662fCD73\u7684\u663e\u8457\u4e0b\u6e38\u6548\u5e94\u56e0\u5b50\u3002CD73\u901a\u8fc7\u80bf\u7624\u7ec6\u80de\u81ea\u5206\u6ccc\u817a\u82f7-Adora2a\u4fe1\u53f7\u4ecb\u5bfc\u7684p38-STAT1\u8f74\u6fc0\u6d3b\u8f6c\u5f55\u4e0a\u8c03CCL5\uff0c\u4ece\u800c\u62db\u52dfTregs\u81f3\u80f0\u817a\u80bf\u7624\uff0c\u5bfc\u81f4\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u3002\u603b\u4e4b\uff0c\u672c\u7814\u7a76\u5f3a\u8c03\u4e86CD73-\u817a\u82f7\u4ee3\u8c22\u4ee5\u80bf\u7624\u81ea\u4e3b\u548c\u81ea\u5206\u6ccc\u65b9\u5f0f\u8f6c\u5f55\u8c03\u63a7\u80f0\u817a\u764c\u514d\u75ab\u6291\u5236\u3002\u8fd9\u4e9b\u53d1\u73b0\u6709\u671b\u4e3a\u5f00\u53d1\u66f4\u6709\u6548\u7684\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u65b0\u7684\u601d\u8def\u548c\u76ee\u6807\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

13<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Trends Pharmacol Sci. 20230626<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Ferroptosis of immune cells in the tumor microenvironment<\/strong><\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u94c1\u6b7b\u4ea1<\/strong><\/span><\/p>\n

Trends Pharmacol Sci. 2023 Jun 26;S0165-6147(23)00132-3. <\/em><\/p>\n

doi: <\/strong>10.1016\/j.tips.2023.06.005.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37380530\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u94c1\u6b7b\u4ea1\u662f\u4e00\u79cd\u7279\u6b8a\u7684\u7ec6\u80de\u6b7b\u4ea1\u5f62\u5f0f\uff0c\u5b83\u7531\u8fc7\u6c27\u5316\u8102\u8d28\u7684\u79ef\u7d2f\u5f15\u53d1\u3002\u94c1\u6b7b\u4ea1\u7684\u7279\u5f81\u4e4b\u4e00\u662f\u6c27\u5316\u8fd8\u539f\u8102\u8d28\u4ee3\u8c22\u7684\u6539\u53d8\u3002\u5b83\u5728\u5305\u62ec\u764c\u75c7\u5728\u5185\u7684\u591a\u79cd\u7ec6\u80de\u8fc7\u7a0b\u4e2d\u88ab\u53d1\u73b0\u3002\u8bf1\u5bfc\u94c1\u6b7b\u4ea1\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u65b0\u9896\u7684\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u7684\u65b9\u6cd5\uff0c\u7279\u522b\u662f\u5bf9\u8f90\u5c04\u548c\u5316\u7597\u62b5\u6297\u7684\u7ec6\u80de\u3002\u7136\u800c\uff0c\u6700\u8fd1\u51fa\u73b0\u4e86\u4e00\u4e2a\u65b0\u7684\u8303\u5f0f\u3002\u94c1\u6b7b\u4ea1\u4e0d\u4ec5\u80fd\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\uff0c\u800c\u4e14\u8fd8\u80fd\u901a\u8fc7\u5f71\u54cd\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u5f15\u8d77\u5f3a\u70c8\u7684\u514d\u75ab\u6291\u5236\u3002\u5728\u672c\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u94c1\u6b7b\u4ea1\u5728\u6297\u80bf\u7624\u548c\u4fc3\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u4e2d\u7684\u53cc\u91cd\u4f5c\u7528\u3002\u8003\u8651\u5230\u5176\u5728\u764c\u75c7\u4e2d\u7684\u53cc\u91cd\u4f5c\u7528\uff0c\u6211\u4eec\u63d0\u51fa\u4e86\u4e00\u4e9b\u9488\u5bf9\u94c1\u6b7b\u4ea1\u7684\u7b56\u7565\u3002<\/p>\n

Keywords:<\/strong><\/p>\n

\u9ad3\u6837\u6291\u5236\u6027\u7ec6\u80de\uff1b\u764c\u75c7\uff1b\u94c1\u6b7b\u4ea1\uff1b\u5de8\u566c\u7ec6\u80de\uff1b\u5355\u6838\u7ec6\u80de\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

14<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Nat Rev Clin Oncol. 20230626<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy<\/strong><\/p>\n

\u80a0\u9053\u80bf\u7624\u76f8\u5173\u5fae\u751f\u7269\u7ec4\u7279\u5f81\uff08GOMS\uff09\u4f5c\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u4e0b\u4e00\u4ee3\u751f\u7269\u6807\u5fd7\u7269<\/strong><\/span><\/p>\n

Nat Rev Clin Oncol. 2023 Jun 26.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41571-023-00785-8.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37365438\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u80bf\u7624\u7684\u53d1\u751f\u4e0e\u80a0\u9053\u83cc\u7fa4\u5931\u8c03\u6709\u5173\uff0c\u56e0\u6b64\u5bf9\u4e8e\u60a3\u6709\u8fd9\u79cd\u60c5\u51b5\u7684\u4e2a\u4f53\u8fdb\u884c\u7caa\u4fbf\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u53ef\u80fd\u662f\u4e00\u79cd\u53ef\u7528\u4e8e\u65e9\u671f\u8bca\u65ad\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u975e\u4fb5\u5165\u6027\u65b9\u6cd5\u3002\u6297\u751f\u7d20\u7684\u4f7f\u7528\u548c\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210\u7684\u9884\u540e\u76f8\u5173\u6027\u63a8\u52a8\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u7528\u4e8e\u68c0\u6d4b\u80a0\u9053\u83cc\u7fa4\u5931\u8c03\u7684\u5de5\u5177\uff0c\u4ee5\u5b9e\u73b0\u60a3\u8005\u5206\u5c42\u548c\u4ee5\u83cc\u7fa4\u4e3a\u4e2d\u5fc3\u7684\u4e34\u5e8a\u5e72\u9884\u3002\u6b64\u5916\uff0c\u81ea\u4ece\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u5728\u80bf\u7624\u5b66\u4e2d\u51fa\u73b0\u4ee5\u6765\uff0c\u786e\u5b9a\u9884\u6d4b\u5176\u7597\u6548\u7684\u751f\u7269\u6807\u5fd7\u7269\u4e00\u76f4\u662f\u4e00\u4e2a\u672a\u80fd\u6ee1\u8db3\u7684\u533b\u5b66\u9700\u6c42\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u8bb8\u591a\u7814\u7a76\u5df2\u7ecf\u63cf\u8ff0\u4e86\u80a0\u9053\u80bf\u7624\u5fae\u751f\u7269\u7ec4\u7279\u5f81\uff08GOMS\uff09\uff0c\u5305\u62ec\u672c\u6587\u4e2d\u63cf\u8ff0\u7684\u4e00\u9879\u835f\u8403\u5206\u6790\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u8ba8\u8bba\u4e86\u60a3\u6709\u4e0d\u540c\u4e9a\u578b\u764c\u75c7\u7684\u60a3\u8005\u5982\u4f55\u4e0e\u770b\u4f3c\u65e0\u5173\u7684\u6162\u6027\u708e\u75c7\u6027\u75be\u75c5\u60a3\u8005\u5171\u4eab\u591a\u4e2aGOMS\uff0c\u800c\u540e\u8005\u5f80\u5f80\u5177\u6709\u4e0e\u5065\u5eb7\u4e2a\u4f53\u4e0d\u540c\u7684GOMS\u3002\u6211\u4eec\u7740\u91cd\u8ba8\u8bba\u4e86\u835f\u8403\u5206\u6790\u7ed3\u679c\uff0c\u8fd9\u4e9b\u7ed3\u679c\u63cf\u8ff0\u4e86\u4e0e\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\uff08808\u4f8b\u60a3\u8005\uff09\u7684ICI\u4e34\u5e8a\u76ca\u5904\u6216\u6297\u6027\u76f8\u5173\u7684GOMS\u6a21\u5f0f\uff0c\u5176\u4e2d\u91cd\u70b9\u5173\u6ce8\u4e86\u80a0\u9053\u83cc\u7fa4\u5931\u8c03\u7684\u4ee3\u8c22\u548c\u514d\u75ab\u66ff\u4ee3\u6807\u5fd7\u7269\uff0c\u5e76\u63d0\u51fa\u4e86\u5c06GOMS\u7eb3\u5165\u514d\u75ab\u80bf\u7624\u5b66\u524d\u77bb\u6027\u4e34\u5e8a\u8bd5\u9a8c\u51b3\u7b56\u7684\u5b9e\u7528\u6307\u5357\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n

15<\/strong><\/p>\n<\/section>\n<\/section>\n

\n
\n

Signal Transduct Target Ther. 20230626<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/svg><\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
<\/svg><\/section>\n<\/section>\n
\n
\n
\n

TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance<\/strong><\/p>\n

TRIM28\u901a\u8fc7\u589e\u52a0PD-L1\u4e30\u5ea6\u4fc3\u8fdb\u80c3\u764c\u7ec6\u80de\u514d\u75ab\u76d1\u89c6\u9003\u9038<\/strong><\/span><\/p>\n

Signal Transduct Target Ther. 2023 Jun 26;8(1):246.<\/em><\/p>\n

doi: <\/strong>10.1038\/s41392-023-01450-3.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37357254\/<\/span><\/p>\n

Abstract<\/strong><\/span><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u4e3a\u80c3\u764c\uff08G.C.\uff09\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u9047\u3002\u8fdb\u4e00\u6b65\u63d0\u9ad8ICB\u7597\u6cd5\u7684\u6548\u679c\u9700\u8981\u7406\u89e3\u514d\u75ab\u68c0\u67e5\u70b9\u4e0a\u6e38\u8c03\u63a7\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u901a\u8fc7CRISPR-Cas9\u57fa\u56e0\u7ec4\u5168\u9762\u7b5b\u9009\uff0c\u786e\u8ba4TRIM28\u662f\u80c3\u764c\u7ec6\u80de\u4e2dPD-L1\uff08\u4e00\u79cd\u68c0\u67e5\u70b9\u86cb\u767d\uff09\u6700\u663e\u8457\u7684\u8c03\u63a7\u56e0\u5b50\u4e4b\u4e00\u3002TRIM28\u53ef\u4ee5\u76f4\u63a5\u4e0ePD-L1\u7ed3\u5408\uff0c\u5e76\u901a\u8fc7\u6291\u5236PD-L1\u7684\u6cdb\u7d20\u5316\u548c\u4fc3\u8fdbPD-L1\u7684SUMO\u5316\u6765\u7a33\u5b9aPD-L1\u3002\u6b64\u5916\uff0cTRIM28\u4fc3\u8fdb\u4e86TBK1\u7684K63\u591a\u805a\u6cdb\u7d20\u5316\uff0c\u6fc0\u6d3b\u4e86TBK1-IRF1\u548cTBK1-mTOR\u9014\u5f84\uff0c\u4ece\u800c\u589e\u5f3a\u4e86PD-L1\u7684\u8f6c\u5f55\u3002\u6211\u4eec\u53d1\u73b0\uff0cTRIM28\u4e0e\u80c3\u764c\u7ec6\u80de\u4e2d\u7684PD-L1\u5448\u6b63\u76f8\u5173\u3002\u6b64\u5916\uff0c466\u4f8b\u80c3\u764c\u60a3\u8005\u7684\u961f\u5217\u7814\u7a76\u663e\u793a\u9ad8TRIM28\u8868\u8fbe\u63d0\u793a\u9884\u540e\u4e0d\u826f\uff0c\u8fd9\u4e00\u89c2\u5bdf\u5728\u5206\u6790\u516c\u5f00\u6570\u636e\u5e93\u6570\u636e\u65f6\u4e5f\u5f97\u5230\u8bc1\u5b9e\u3002\u5f02\u4f4d\u8868\u8fbeTRIM28\u4fc3\u8fdb\u5c0f\u9f20\u80bf\u7624\u751f\u957f\uff0c\u589e\u52a0PD-L1\u7684\u8868\u8fbe\uff0c\u5e76\u6291\u5236T\u7ec6\u80de\u6fc0\u6d3b\u3002\u4f7f\u7528PD-L1\u6216TBK1\u6291\u5236\u5242\u53ef\u4ee5\u663e\u8457\u51cf\u8f7bTRIM28\u8bf1\u5bfc\u7684\u80bf\u7624\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u8054\u5408\u4f7f\u7528TBK1\u6291\u5236\u5242\u548cCTLA4\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u5bf9\u80c3\u764c\u5177\u6709\u534f\u540c\u4f5c\u7528\uff0c\u8fd9\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u9001202306\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/section>\n
\u7b5b\u9009\u7ffb\u8bd1\u6574\u7406 | \u738b\u5764<\/span><\/span><\/span><\/section>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

01 Cell. 20230609 DNA hypomethylation silences anti-tum…<\/p>\n","protected":false},"author":1,"featured_media":3071,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[63],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3087"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3087"}],"version-history":[{"count":1,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3087\/revisions"}],"predecessor-version":[{"id":3213,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3087\/revisions\/3213"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3071"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3087"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3087"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3087"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}