{"id":3119,"date":"2023-09-26T13:10:34","date_gmt":"2023-09-26T05:10:34","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/09\/26\/monthly-updates-2023-08\/"},"modified":"2025-01-03T18:47:52","modified_gmt":"2025-01-03T10:47:52","slug":"monthly-updates-2023-08","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/09\/26\/monthly-updates-2023-08\/","title":{"rendered":"Monthly Updates 2023.08"},"content":{"rendered":"
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Monthly Updates 2023.07<\/a><\/p>\n

Monthly Updates 2023.06<\/a><\/p>\n

Monthly Updates 2023.05<\/a><\/p>\n

Monthly Updates 2023.04<\/a><\/p>\n

Monthly Updates 2023.03<\/a><\/p>\n

Monthly Updates 2023.02<\/a><\/p>\n

Monthly Updates 2023.01<\/a><\/p>\n

Monthly Updates 2022.12<\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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01<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Clin Invest. 20230801<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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J Clin Invest. 2023 Aug 1;133(15):e167629.<\/em><\/p>\n

doi: <\/strong>10.1172\/JCI167629.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37526080\/<\/span><\/p>\n

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J Extracell Vesicles. 20230801<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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J Extracell Vesicles. 2023 Aug;12(8):e12350.<\/em><\/p>\n

doi: <\/strong>10.1002\/jev2.12350.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37525396\/<\/span><\/p>\n

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03<\/strong><\/p>\n<\/section>\n<\/section>\n

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Gut. 20230728<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Gut. 2023 Jul 28;gutjnl-2022-329147.<\/em><\/p>\n

doi: <\/strong>10.1136\/gutjnl-2022-329147.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37507218\/<\/span><\/p>\n

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Cell Metab. 20230727<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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Cell Metab. 2023 Jul 27;S1550-4131(23)00251-6.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cmet.2023.07.001.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37506695\/<\/span><\/p>\n

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\u4ee3\u8c22\u91cd\u7f16\u7a0b\u8f6c\u5411\u7cd6\u9175\u89e3\u662f\u764c\u75c7\u7684\u6076\u6027\u6807\u5fd7\u3002\u80bf\u7624\u7cd6\u9175\u89e3\u9014\u5f84\u5982\u4f55\u4fc3\u8fdb\u514d\u75ab\u9003\u907f\u7684\u5206\u5b50\u673a\u5236\u4ecd\u5f85\u9610\u8ff0\u3002\u5728\u8fd9\u91cc\uff0c\u901a\u8fc7\u5728\u4e0e\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08CTLs\uff09\u5171\u57f9\u517b\u7684\u5c0f\u9f20\u80bf\u7624\u7ec6\u80de\u4e2d\u8fdb\u884c\u5168\u57fa\u56e0\u7ec4CRISPR\u7b5b\u9009\uff0c\u6211\u4eec\u53d1\u73b0\u4e24\u79cd\u91cd\u8981\u7684\u7cd6\u9175\u89e3\u9176\uff0cGlut1\uff08\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d1\uff09\u548cGpi1\uff08\u8461\u8404\u7cd6-6-\u78f7\u9178\u5f02\u6784\u91761\uff09\u7684\u7f3a\u4e4f\u5bfc\u81f4CTLs\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u589e\u5f3a\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cGlut1\u7684\u5931\u6d3b\u5bfc\u81f4\u4ee3\u8c22\u91cd\u7f16\u7a0b\u8f6c\u5411\u6c27\u5316\u78f7\u9178\u5316\uff0c\u4ea7\u751f\u8fc7\u91cf\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u3002\u79ef\u7d2f\u7684ROS\u901a\u8fc7caspase-8\u548cFadd\u4f9d\u8d56\u7684\u65b9\u5f0f\u589e\u5f3a\u80bf\u7624\u574f\u6b7b\u56e0\u5b50alpha\uff08TNF-\u03b1\uff09\u4ecb\u5bfc\u7684\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002Glut1\u7684\u9057\u4f20\u548c\u836f\u7406\u5b66\u5931\u6d3b\u4f7f\u80bf\u7624\u5bf9\u6297\u80bf\u7624\u514d\u75ab\u654f\u611f\uff0c\u5e76\u901a\u8fc7TNF-\u03b1\u901a\u8def\u4e0e\u6297PD-1\u7597\u6cd5\u534f\u540c\u4f5c\u7528\u3002\u80bf\u7624\u672c\u8eab\u7cd6\u9175\u89e3\u4e0eTNF-\u03b1\u8bf1\u5bfc\u6740\u4f24\u4e4b\u95f4\u673a\u5236\u4e0a\u7684\u76f8\u4e92\u4f5c\u7528\u63d0\u4f9b\u4e86\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u7684\u6cbb\u7597\u65b0\u7b56\u7565\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

T\u7ec6\u80de\u4ecb\u5bfc\u7684\u6740\u4f24\uff1bTNF-\u03b1\uff1b\u7cd6\u9175\u89e3\uff1b\u514d\u75ab\u9003\u907f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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05<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230802<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bfc\u81f4\u80bf\u7624\u514d\u75ab\u9003\u907f\u7684\u4e00\u79cd\u819c\u76f8\u5173\u7684MHC-I\u6291\u5236\u8f74<\/strong>
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Cell. 2023 Aug 2;S0092-8674(23)00783-3.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.07.016.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37557169\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u5df2\u7ecf\u9769\u547d\u6027\u5730\u6539\u53d8\u4e86\u764c\u75c7\u6cbb\u7597\uff0c\u4f46\u4e00\u4e9b\u764c\u75c7\uff0c\u5982\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\uff0c\u65e0\u6cd5\u54cd\u5e94\u6216\u4ea7\u751f\u6297\u836f\u6027\u3002\u4ea7\u751f\u6297\u836f\u6027\u7684\u4e00\u79cd\u53ef\u80fd\u6a21\u5f0f\u662f\u901a\u8fc7\u5f02\u5e38\u7684\u4e3b\u8981\u7ec4\u7ec7\u517c\u5bb9\u6027\u590d\u5408\u4f53I\u7c7b\uff08MHC-I\uff09\u6297\u539f\u5448\u9012\u9003\u907fT\u7ec6\u80de\u514d\u75ab\u3002\u4e3a\u4e86\u63cf\u7ed8\u8fd9\u79cd\u6297\u836f\u6027\u673a\u5236\uff0c\u6211\u4eec\u5229\u7528\u5728AML\u4e2d\u7684\u7279\u5f02\u6027\u80bd-MHC-I\u5f15\u5bfc\u7684CRISPR-Cas9\u7b5b\u9009\uff0c\u786e\u5b9a\u4e86\u5173\u952e\u7684MHC-I\u8c03\u63a7\u56e0\u5b50\u3002\u6392\u540d\u6700\u9ad8\u7684\u8d1f\u8c03\u63a7\u56e0\u5b50\u662fSUSD6\uff0c\u8de8\u819c\u86cb\u767d127\uff08TMEM127\uff09\uff0c\u548cE3\u6cdb\u7d20\u8fde\u63a5\u9176WWP2\u3002SUSD6\u5728AML\u548c\u591a\u79cd\u5b9e\u4f53\u764c\u75c7\u4e2d\u8868\u8fbe\u4e30\u5bcc\uff0c\u5176\u6d88\u9664\u589e\u5f3a\u4e86MHC-I\u7684\u6297\u539f\u5448\u9012\u5e76\u4ee5CD8+ T\u7ec6\u80de\u4f9d\u8d56\u7684\u65b9\u5f0f\u51cf\u5c11\u4e86\u80bf\u7624\u751f\u957f\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cSUSD6\u5f62\u6210\u4e86\u4e0eTMEM127\u548cMHC-I\u7684\u4e09\u5206\u5b50\u590d\u5408\u7269\uff0c\u8fd9\u4e2a\u590d\u5408\u7269\u62db\u52dfWWP2\u8fdb\u884cMHC-I\u7684\u6cdb\u7d20\u5316\u548c\u6eb6\u9176\u4f53\u964d\u89e3\u3002\u7ed3\u5408SUSD6\/TMEM127\/WWP2\u7684\u57fa\u56e0\u7279\u5f81\uff0c\u8fd9\u4e0e\u764c\u75c7\u751f\u5b58\u7387\u5448\u8d1f\u76f8\u5173\uff0c\u6211\u4eec\u7684\u53d1\u73b0\u5b9a\u4e49\u4e86\u4e00\u4e2a\u819c\u76f8\u5173\u7684MHC-I\u6291\u5236\u8f74\uff0c\u8fd9\u53ef\u80fd\u662f\u767d\u8840\u75c5\u548c\u5b9e\u4f53\u764c\u75c7\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

MHC-I\uff1bSUSD6\uff1bT\u7ec6\u80de\uff1bTMEM127\uff1bWWP2\uff1b\u6297\u539f\u5448\u9012\uff1b\u764c\u75c7\uff1b\u514d\u75ab\u9003\u907f\uff1b\u6eb6\u9176\u4f53\u964d\u89e3\uff1b\u6cdb\u7d20\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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06<\/strong><\/p>\n<\/section>\n<\/section>\n

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Cell. 20230809<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ffb\u8bd1\u540e\u4fee\u9970\u7684\u6cdb\u764c\u5206\u6790\u63ed\u793a\u4e86\u86cb\u767d\u8d28\u8c03\u63a7\u7684\u5171\u6709\u6a21\u5f0f<\/strong>
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Cell. 2023 Aug 9;S0092-8674(23)00781-X.<\/em><\/p>\n

doi: <\/strong>10.1016\/j.cell.2023.07.013.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37582358\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u7ffb\u8bd1\u540e\u4fee\u9970\uff08PTMs\uff09\u5728\u6b63\u5e38\u7ec6\u80de\u548c\u764c\u7ec6\u80de\u7684\u4fe1\u53f7\u8c03\u63a7\u548c\u751f\u7406\u8fc7\u7a0b\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u8d28\u8c31\u6280\u672f\u7684\u8fdb\u6b65\u4f7f\u5f97\u5bf9PTM\u6c34\u5e73\u7684\u9ad8\u901a\u91cf\u3001\u51c6\u786e\u548c\u7075\u654f\u7684\u68c0\u6d4b\u6210\u4e3a\u53ef\u80fd\uff0c\u4ee5\u4fbf\u66f4\u597d\u5730\u7406\u89e3\u5b83\u4eec\u7684\u89d2\u8272\u3001\u666e\u904d\u6027\u548c\u4ea4\u53c9\u4f5c\u7528\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u5206\u6790\u4e86\u6765\u81ea1,110\u540d\u60a3\u8005\u7684\u6700\u5927\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u6570\u636e\u96c6\uff0c\u8be5\u6570\u636e\u96c6\u5305\u542b\u4e8611\u79cd\u764c\u75c7\u7c7b\u578b\u7684PTM\u5256\u9762\uff08\u5176\u4e2d10\u79cd\u6765\u81ea\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u7684\u4e34\u5e8a\u86cb\u767d\u8d28\u7ec4\u80bf\u7624\u5206\u6790\u8054\u76df[CPTAC]\uff09\u3002\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86\u764c\u75c7\u8fc7\u7a0b\u4e2d\u4e0e\u86cb\u767d\u8d28\u4e59\u9170\u5316\u548c\u78f7\u9178\u5316\u6709\u5173\u7684\u6cdb\u764c\u6539\u53d8\u6a21\u5f0f\u3002\u8fd9\u4e9b\u6a21\u5f0f\u63ed\u793a\u4e86\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684\u80bf\u7624\u5b50\u96c6\uff0c\u5305\u62ec\u90a3\u4e9b\u7531\u78f7\u9178\u5316\u9a71\u52a8\u7684DNA\u4fee\u590d\u8c03\u63a7\u5931\u5e38\u3001\u7531\u4e59\u9170\u5316\u9a71\u52a8\u7684\u4e0e\u514d\u75ab\u53cd\u5e94\u76f8\u5173\u7684\u4ee3\u8c22\u8c03\u63a7\u6539\u53d8\u3001\u901a\u8fc7\u4e59\u9170\u5316\u548c\u78f7\u9178\u5316\u4e4b\u95f4\u7684\u4ea4\u53c9\u4f5c\u7528\u5f71\u54cd\u6fc0\u9176\u7279\u5f02\u6027\uff0c\u4ee5\u53ca\u901a\u8fc7\u7ffb\u8bd1\u540e\u4fee\u9970\u8c03\u8282\u7ec4\u86cb\u767d\u8c03\u63a7\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u4e2a\u8d44\u6e90\u63ed\u793a\u4e86PTMs\u6240\u8c03\u63a7\u7684\u4e30\u5bcc\u751f\u7269\u5b66\u7279\u5f81\uff0c\u5e76\u63d0\u793a\u4e86\u53ef\u80fd\u7684\u65b0\u7684\u6cbb\u7597\u9014\u5f84\u3002<\/p>\n

\u5173\u952e\u8bcd<\/strong><\/p>\n

CPTAC\uff1bDNA\u635f\u4f24\u53cd\u5e94\uff1b\u57fa\u56e0\u7ec4\u5b66\uff1b\u8d28\u8c31\u5b66\uff1b\u4ee3\u8c22\uff1b\u6cdb\u764c\uff1b\u7ffb\u8bd1\u540e\u4fee\u9970\uff1b\u86cb\u767d\u8d28\u7ec4\u5b66\uff1b\u8f6c\u5f55\u7ec4\u5b66\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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07<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Adv. 20230825<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u53cc\u8c03\u86cb\u767d\u8fde\u63a5IL1RL1+\u8c03\u8282\u6027T\u7ec6\u80de\u548c\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4ee5\u635f\u5bb3\u6297\u80bf\u7624\u514d\u75ab<\/strong>
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Sci Adv. 2023 Aug 25;9(34):eadd7399.<\/em><\/p>\n

doi: <\/strong>10.1126\/sciadv.add7399.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37611111\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u548c\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u5171\u540c\u4fc3\u8fdb\u80bf\u7624\u514d\u75ab\u8010\u53d7\u548c\u80bf\u7624\u53d1\u751f\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u9a71\u52a8Treg\u7ec6\u80de\u548cCAF\u534f\u540c\u4f5c\u7528\u7684\u5206\u5b50\u673a\u5236\u4ecd\u7136\u4e0d\u6e05\u695a\u3002\u767d\u7ec6\u80de\u4ecb\u7d2033\uff08IL-33\uff09\u5728\u80bf\u7624\u53d1\u751f\u548c\u7ec4\u7ec7\u4fee\u590d\u8fc7\u7a0b\u4e2d\u589e\u5f3a\u7ea4\u7ef4\u5316\u548cIL1RL1+ Treg\u7ec6\u80de\u7684\u7d2f\u79ef\u3002\u6211\u4eec\u8bc1\u660e\u4e86\u5728Treg\u7ec6\u80de\u4e2d\u7684IL1RL1\u4fe1\u53f7\u901a\u8def\u5927\u5927\u6291\u5236\u4e86IL-33\u548cPD-1\u963b\u65ad\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5168\u80bf\u7624\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNA-seq\uff09\u5206\u6790\u548c\u963b\u65ad\u5b9e\u9a8c\u63ed\u793a\u4e86\u9170\u80fa\u8c03\u7d20\uff08AREG\uff09-\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u8f74\u4ecb\u5bfc\u4e86IL1RL1+ Treg\u7ec6\u80de\u548cCAFs\u4e4b\u95f4\u7684\u4ea4\u4e92\u3002\u6211\u4eec\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86AREG\/EGFR\u8f74\u4f7fTreg\u7ec6\u80de\u80fd\u591f\u4fc3\u8fdbCAFs\u7684\u589e\u751f\u7ea4\u7ef4\u5316\u548c\u514d\u75ab\u6291\u5236\u529f\u80fd\u72b6\u6001\u3002\u6b64\u5916\uff0cAREG\u5355\u514b\u9686\u6297\u4f53\u548cIL-33\u5171\u540c\u6291\u5236\u4e86\u80bf\u7624\u751f\u957f\u3002\u6211\u4eec\u7684\u7814\u7a76\u63ed\u793a\u4e86\u4e00\u4e2a\u4ee5\u524d\u672a\u77e5\u7684\u901a\u8fc7AREG\/EGFR\u4ecb\u5bfc\u7684Treg\/CAF\u8054\u52a8\uff0c\u8fd9\u4e2a\u8054\u52a8\u63a7\u5236\u4e86\u6210\u7ea4\u7ef4\u7ec6\u80de\u529f\u80fd\u72b6\u6001\u7684\u8f6c\u53d8\uff0c\u5e76\u4e14\u662f\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u5173\u952e\u969c\u788d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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08<\/strong><\/p>\n<\/section>\n<\/section>\n

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Sci Transl Med. 20230823<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u8868\u8fbe\u5728CD8+ T\u7ec6\u80de\u4e0a\u7684Fc\u03b3RIIB\u9650\u5236\u4e86\u764c\u75c7\u4e2dPD-1\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u53cd\u5e94\u6027<\/strong>
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Sci Transl Med. 2023 Aug 23;15(710):eadd1868.<\/em><\/p>\n

doi: <\/strong>10.1126\/scitranslmed.add1868.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37611081\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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09<\/strong><\/p>\n<\/section>\n<\/section>\n

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Clin Cancer Res. 20230823<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8111\u8f6c\u79fb\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u6291\u5236CDK4\/6\u4f7f\u9885\u5185\u80bf\u7624\u5bf9PD-1\u963b\u65ad\u654f\u611f<\/strong>
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Clin Cancer Res. 2023 Aug 23;CCR-23-0433.<\/em><\/p>\n

doi: <\/strong>10.1158\/1078-0432.CCR-23-0433.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37611074\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

\u76ee\u7684\uff1a\u8111\u8f6c\u79fb\u7684\u53d1\u75c5\u7387\u9ad8\uff0c\u4e14\u5e38\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u3002\u6211\u4eec\u8bc4\u4f30\u4e86CDK4\/6\u6291\u5236\u5242(CDKi) abemaciclib\u662f\u5426\u53ef\u4ee5\u4f7f\u9ed1\u8272\u7d20\u7624\u548c\u4e73\u817a\u764c\u8111\u8f6c\u79fb\u5c0f\u9f20\u6a21\u578b\u7684\u9885\u5185\u80bf\u7624\u5bf9PD-1\u6291\u5236\u589e\u654f\u3002<\/p>\n

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\u7ed3\u679c\uff1a\u6211\u4eec\u53d1\u73b0\uff0cabemaciclib\u8054\u5408PD-1\u6291\u5236\u53ef\u964d\u4f4e\u5c0f\u9f20\u7684\u80bf\u7624\u8d1f\u8377\u5e76\u6539\u5584\u603b\u751f\u5b58\u671f\u3002\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u56e0\u80bf\u7624\u89e3\u5256\u4f4d\u7f6e\u4e0d\u540c\u800c\u4e0d\u540c\uff0cCDKi\u548cPD-1\u6291\u5236\u53ef\u4ee5\u5668\u5b98\u7279\u5f02\u6027\u65b9\u5f0f\u6539\u53d8\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u3002abemaciclib\u8054\u5408\u6297PD-1\u6cbb\u7597\u589e\u52a0\u4e86\u9885\u5185\u80bf\u7624\u4e2dCD8+\u6548\u5e94T\u7ec6\u80de\u4e9a\u7fa4\u7684\u52df\u96c6\u548c\u6269\u589e\uff0c\u6e05\u9664\u4e86CD4+\u8c03\u8282\u6027T (TREG)\u7ec6\u80de\uff0c\u5e76\u964d\u4f4e\u4e86\u514d\u75ab\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u6c34\u5e73\u3002\u5728\u690d\u5165\u4eba\u7c7b\u514d\u75ab\u7cfb\u7edf\u7684\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u4e2d\uff0cabemaciclib\u6cbb\u7597\u652f\u6301CD8+ T\u7ec6\u80de\u7684\u53d1\u80b2\u548c\u7ef4\u6301\u5e76\u4e14\u53ef\u6e05\u9664TREG\u7ec6\u80de\u3002<\/p>\n

\u7ed3\u8bba\uff1a\u6211\u4eec\u7684\u7ed3\u679c\u5f3a\u8c03\u4e86\u9885\u5185\u548c\u9885\u5916\u80bf\u7624\u7684\u72ec\u7279\u7279\u6027\uff0c\u5e76\u652f\u6301\u5728\u8111\u8f6c\u79fb\u60a3\u8005\u4e2d\u4e34\u5e8a\u7814\u7a76CDK4\/6\u548cPD-1\u6291\u5236\u5242\u7684\u8054\u5408\u5e94\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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10<\/strong><\/p>\n<\/section>\n<\/section>\n

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J Clin Invest. 20230831<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9776\u5411TREM1\u6291\u5236\u9aa8\u9ad3\u6765\u6e90\u7684\u6291\u5236\u6027\u7ec6\u80de\u53ef\u6709\u6548\u589e\u5f3a\u6297\u80bf\u7624T\u7ec6\u80de\u514d\u75ab\u5e76\u9650\u5236\u6297PD-1\u8010\u836f<\/strong>
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J Clin Invest. 2023 Aug 31;e167951.<\/em><\/p>\n

doi: <\/strong>10.1172\/JCI167951.<\/p>\n

PubMed:<\/strong><\/span><\/p>\n

https:\/\/pubmed.ncbi.nlm.nih.gov\/37651197\/<\/span><\/p>\n

\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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