{"id":3156,"date":"2023-09-02T00:12:54","date_gmt":"2023-09-01T16:12:54","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/09\/02\/pnas-20230809%ef%bc%9a%e6%8a%97ctla-4%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e4%bd%9c%e7%94%a8%e6%9c%ba%e5%88%b6%e7%9a%84%e6%96%b0%e8%ae%a4%e8%af%86\/"},"modified":"2023-09-02T00:12:54","modified_gmt":"2023-09-01T16:12:54","slug":"pnas-20230809%ef%bc%9a%e6%8a%97ctla-4%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e4%bd%9c%e7%94%a8%e6%9c%ba%e5%88%b6%e7%9a%84%e6%96%b0%e8%ae%a4%e8%af%86","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/09\/02\/pnas-20230809%ef%bc%9a%e6%8a%97ctla-4%e5%85%8d%e7%96%ab%e6%a3%80%e6%9f%a5%e7%82%b9%e9%98%bb%e6%96%ad%e4%bd%9c%e7%94%a8%e6%9c%ba%e5%88%b6%e7%9a%84%e6%96%b0%e8%ae%a4%e8%af%86\/","title":{"rendered":"PNAS. 20230809\uff1a\u6297CTLA-4\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u4f5c\u7528\u673a\u5236\u7684\u65b0\u8ba4\u8bc6"},"content":{"rendered":"
\n
\n
\n
<\/section>\n<\/section>\n
\n
\n
\n

\u6297CTLA-4\u7597\u6cd5\u7684\u4f5c\u7528\u673a\u5236\u4ecd\u7136\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u6709\u5047\u8bbe\u8ba4\u4e3a\u5176\u7597\u6548\u53ef\u80fd\u6e90\u81eaCTLA-4:B7\u7ed3\u5408\u7684\u62ee\u6297\u4f5c\u7528\u6216\u662f\u901a\u8fc7Fc\u6548\u5e94\u5668\u4ecb\u5bfc\u7684\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u6d88\u8017\u3002Lax\u7b49\u4eba\u4f7f\u7528\u5de5\u7a0b\u5316\u6297\u4f53\u7814\u7a76\u4e86\u8fd9\u4e24\u79cd\u673a\u5236\uff0c\u901a\u8fc7\u6d4b\u8bd5\u5355\u72ec\u548c\u8054\u5408\u7684\u62ee\u6297\u4e0eTreg\u6d88\u8017\u7279\u6027\uff0c\u4ee5\u786e\u5b9a\u54ea\u79cd\u673a\u5236\u5bfc\u81f4\u4e86\u6297\u80bf\u7624\u6548\u679c\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u6700\u8fd1\u5728\u300a\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\u300b\uff08PNAS\uff09\u4e0a\u53d1\u8868\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7814\u7a76\u4eba\u5458\u5229\u7528\u9175\u6bcd\u8868\u9762\u5c55\u793a\uff08YSD\uff09\u6280\u672f\u548c\u4ee5DNA\u7ed3\u5408\u86cb\u767dSso7d\u4e3a\u6846\u67b6\u7684\u6587\u5e93\uff0c\u6765\u8bc6\u522b\u4e0eB7\u975e\u7ade\u4e89\u6027\u7ed3\u5408\u7684CTLA-4\u7ed3\u5408\u7269\u3002\u4ed6\u4eec\u9009\u62e9\u5e76\u5bcc\u96c6\u4e86\u5bf9CTLA-4-Fc\u6709\u6700\u9ad8\u4eb2\u548c\u529b\u7684\u7ed3\u5408\u7269\uff0c\u7b5b\u9009\u8fc7\u7a0b\u5728\u8fc7\u91cf\u7684B7.1-Fc\u5b58\u5728\u4e0b\u8fdb\u884c\uff0c\u4ee5\u6d88\u9664\u90a3\u4e9b\u9488\u5bf9CTLA-4\u4e0a\u7684B7.1\u7ed3\u5408\u4f4d\u70b9\u7684\u7ed3\u5408\u7269\u3002\u8fd9\u5bfc\u81f4\u4e86\u4e00\u4e2a\u5355\u514b\u9686\uff08b1s1\uff09\uff0c\u5176\u5bf9\u7ec6\u80de\u8868\u9762CTLA-4\u7684\u5355\u4f53\u4eb2\u548c\u529b\u65e0\u6cd5\u68c0\u6d4b\u3002\u7ecf\u8fc7\u4e24\u8f6e\u7684\u4eb2\u548c\u529b\u6210\u719f\u540e\uff0c\u5236\u5907\u4e86\u4e00\u4e2a\u4e8c\u805a\u4f53mIgG2c-Fc\u878d\u5408\u4f53\uff0c\u521b\u9020\u4e86\u201c\u975e\u62ee\u6297\u6027\u201db1s1e2-Fc\u3002\u4f5c\u4e3a\u5bf9\u6bd4\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u201c\u62ee\u6297\u6027\u201dmIgG2c 9d9\u6297\u4f53\uff0c\u5b83\u80fd\u7ade\u4e89\u6027\u5730\u6291\u5236B7\u4e0eCTLA-4\u7684\u4e92\u4f5c\u3002b1s1e2-Fc\u548c9d9\u5bf9\u7ec6\u80de\u8868\u9762CTLA-4\u7684\u4eb2\u548c\u529b\u76f8\u8fd1\uff0c\u56e0\u6b64\u53ef\u4ee5\u5bf9\u8fd9\u4e24\u79cd\u7597\u6cd5\u8fdb\u884c\u6bd4\u8f83\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e3a\u4e86\u786e\u8ba4b1s1e2-Fc\u4e0eB7.1\u7ed3\u5408\u7684\u6297\u539f\u51b3\u5b9a\u7c07\uff08epitope\uff09\u4e0d\u540c\uff0c\u7814\u7a76\u8005\u5f00\u53d1\u4e86\u4e00\u4e2a\u9175\u6bcd\u8868\u9762\u5c55\u793a\uff08YSD\uff09\u7cfb\u7edf\uff0c\u901a\u8fc7\u5728\u9175\u6bcd\u8868\u9762\u5c55\u793a\u7684CTLA-4\u7a81\u53d8\u5e93\u8fdb\u884c\u6297\u539f\u51b3\u5b9a\u7c07\u6620\u5c04\uff0c\u5e76\u5bcc\u96c6\u4e86\u65e0\u6cd5\u7ed3\u5408B7.1-Fc\u6216b1s1e2-Fc\u7684CTLA-4\u53d8\u79cd\u3002b1s1e2-Fc\u7684\u6297\u539f\u51b3\u5b9a\u7c07\u6620\u5c04\u8868\u660e\uff0cF67\u8fd9\u4e00\u5355\u4e2a\u6b8b\u57fa\u5bf9\u5176\u7ed3\u5408\u662f\u5fc5\u9700\u7684\uff0c\u8fd9\u4e00\u6b8b\u57fa\u4f4d\u4e8eCTLA-4\u7684\u53e6\u4e00\u4e2a\u73af\u4e2d\uff0c\u4e0e\u5df2\u77e5\u80fd\u591f\u7ed3\u5408B7\u7684\u5178\u578b\u201cMYPPPY\u201d\u533a\u57df\u4e0d\u540c\uff0c\u4ece\u800c\u786e\u8ba4\u4e86\u4e00\u4e2a\u4e0d\u540c\u7684\u6297\u539f\u51b3\u5b9a\u7c07\u3002\u5f53\u6bd4\u8f83b1s1e2-Fc\u4e0eCTLA-4WT\u548cCTLA-4F67L\u7684\u7ed3\u5408\u60c5\u51b5\u65f6\uff0c9d9\u5bf9\u4e24\u8005\u7684\u7ed3\u5408\u529b\u4e00\u6837\uff0c\u800cb1s1e2-Fc\u53ea\u80fd\u7ed3\u5408CTLA-4WT\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7531\u4e8eCTLA-4\u7684\u7ec6\u80de\u5916\u533a\u57df\u8f83\u5c0f\uff0c\u5982\u679c\u7acb\u4f53\u963b\u788d\u963b\u6b62\u4e86b1s1e2-Fc\u548cB7\u7684\u7ed3\u5408\uff0c\u90a3\u4e48\u4e00\u4e2a\u72ec\u7acb\u7684\u6297\u539f\u51b3\u5b9a\u7c07\u53ef\u80fd\u4e0d\u8db3\u4ee5\u5b8c\u5168\u975e\u7ade\u4e89\u6027\u5730\u6291\u5236B7\u3002\u4e3a\u4e86\u68c0\u9a8c\u8fd9\u4e00\u70b9\uff0c\u7814\u7a76\u8005\u6d4b\u91cf\u4e86CTLA-4\u7ed3\u5408\u5230B7.1\u5305\u88ab\u677f\u7684\u7ed3\u5408\u4eb2\u548c\u529b\u7684\u964d\u4f4e\uff0c\u5e76\u5c06\u5176\u4e0eCTLA-4\u5305\u88ab\u677f\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\u7ed3\u679c\u8868\u660e\uff0c\u5373\u4f7fCTLA-4\u4e0eB7.1\u7ed3\u5408\uff0cb1s1e2-Fc\u4e5f\u80fd\u7ed3\u5408CTLA-4\uff0c\u800c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c9d9\u7684\u7ed3\u5408\u529b\u4f1a\u964d\u4f4e\u3002\u7531\u4e8eCTLA-4\u7684\u62ee\u6297\u4f5c\u7528\u4f1a\u963b\u65adCTLA-4:B7\u8f74\uff0c\u5e76\u963b\u6b62CTLA-4\u5bf9B7\u8fdb\u884c\u8de8\u5185\u541e\u4f5c\u7528\uff0c\u6240\u4ee5\u901a\u8fc7\u5728\u5b58\u5728CTLA-4\u7ed3\u5408\u7269\u7684\u60c5\u51b5\u4e0b\uff0c\u7528\u8868\u8fbeCTLA-4\u7684\u53d7\u4f53\u7ec6\u80de\u4e0e\u542b\u6709B7.1\u6216B7.2\u7684\u4f9b\u4f53\u7ec6\u80de\u5b75\u80b2\uff0c\u6765\u6d4b\u91cfb1s1e2-Fc\u5bf9B7\u8de8\u5185\u541e\u4f5c\u7528\u7684\u5f71\u54cd\u3002\u7ecf\u8fc7\u4e00\u591c\u5b75\u80b2\u540e\uff0c\u5269\u4f59\u7684\u914d\u4f53\u5bf9\u4e8eb1s1e2-Fc\u6216\u65e0\u6297\u4f53\u800c\u8a00\u76f8\u4f3c\uff0c\u800c9d9\u5219\u5bfc\u81f4B7.1\u548cB7.2\u7684\u6570\u91cf\u589e\u52a0\uff0c\u8fd9\u8868\u660eb1s1e2-Fc\u5e76\u672a\u529f\u80fd\u6027\u5730\u963b\u6b62CTLA-4\uff0c\u6216\u6291\u5236\u8de8\u5185\u541e\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u81f3\u4e8eTreg\u6d88\u8017\u7684\u8bc4\u4f30\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86MC38\u7ed3\u80a0\u764c\u5c0f\u9f20\u6a21\u578b\u3002\u5c0f\u9f20\u76ae\u4e0b(SC)\u63a5\u79cd\u80bf\u7624\u7ec6\u80de\uff0c\u7136\u540e\u5728\u7b2c7\u5929\u8179\u8154(IP)\u6216\u7624\u5185(IT)\u6ce8\u5c04b1s1e2-Fc\u548c9d9\u3002\u4e00\u5929\u540e\uff0c\u5bf9\u80bf\u7624\u8fdb\u884c\u5206\u6790\u3002b1s1e2-Fc\u548c9d9\u90fd\u80fd\u51cf\u5c11\u80bf\u7624\u4e2d\u7684Tregs\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u901a\u8fc7\u5728Fc\u4e2d\u5f15\u5165LALA-PG\u7a81\u53d8\u6765\u53bb\u9664\u4e0eFc\u03b3Rs\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u521b\u5efa\u4e86\u6c89\u9ed8Fc\u7ed3\u6784\u7684\u65b9\u6cd5\uff0c\u800c\u8fd9\u79cd\u65b9\u6cd5\u672c\u8eab\u4e0d\u4f1a\u8017\u5c3dTregs\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u4e86\u6bcf\u79cd\u6784\u5efa\u7269\u53ca\u5176\u9759\u9ed8Fc\u5f62\u5f0f\u7684\u6cbb\u7597\u6548\u679c\u3002\u62e5\u6709SC MC38\u80bf\u7624\u7684\u5c0f\u9f20\u5728\u7b2c7\u300110\u548c14\u5929\u901a\u8fc7IT\u6216IP\u65b9\u5f0f\u63a5\u53d7\u4e86\u8fd9\u4e9b\u6784\u5efa\u7269\u7684\u5242\u91cf\uff0c\u7136\u540e\u8bc4\u4f30\u4e86\u5176\u751f\u5b58\u60c5\u51b5\u3002\u4e0e\u5bf9\u7167\u5c0f\u9f20\u76f8\u6bd4\uff0c\u63a5\u53d79d9 WT\u6216b1s1e2-Fc WT\u7684IT\u6cbb\u7597\u7684\u5c0f\u9f20\u751f\u5b58\u7387\u663e\u8457\u63d0\u9ad8\uff0c\u4f469d9 WT\u6cbb\u6108\u4e86\u66f4\u591a\u5c0f\u9f20\uff0847%\uff09\uff0c\u800cb1s1e2-Fc\u5219\u6ca1\u6709\u6cbb\u6108\uff080%\uff09\u3002\u9759\u9ed8Fc\u76849d9\u7ed3\u679c\u4e0e\u5bf9\u7167\u5c0f\u9f20\u7684\u751f\u5b58\u72b6\u51b5\u76f8\u4f3c\uff0c\u8fd9\u8868\u660e\u5355\u72ec\u7684CTLA-4\u62ee\u6297\u7597\u6cd5\u5e76\u4e0d\u6709\u6548\u3002\u7531\u4e8eb1s1e2-Fc\u5e76\u4e0d\u62ee\u6297CTLA-4\uff0c\u9759\u9ed8Fc\u5b8c\u5168\u6d88\u9664\u4e86\u5176\u6cbb\u7597\u6548\u679c\u3002IP\u7ed9\u836f\u7684\u6548\u679c\u4e0eIT\u6cbb\u7597\u76f8\u4f3c\u3002\u603b\u7684\u6765\u8bf4\uff0c9d9 WT\u6bd4b1s1e2-Fc\u5e26\u6765\u4e86\u66f4\u5927\u7684\u76ca\u5904\uff0c\u8fd9\u8868\u660eCTLA-4\u62ee\u6297\u548c\u80bf\u7624\u5185Treg\u8017\u7aed\u540c\u65f6\u53d1\u751f\u4f1a\u5e26\u6765\u6700\u597d\u7684\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86\u6cbb\u7597\u5bf9\u80bf\u7624\u5f15\u6d41\u6dcb\u5df4\u7ed3\uff08TDLN\uff09\u7684\u5f71\u54cd\u3002\u643a\u5e26MC38\u7684\u5c0f\u9f20\u5728\u7b2c7\u5929\u63a5\u53d7\u5242\u91cf\uff0c\u7b2c10\u5929\u8fdb\u884cTDLN\u8bc4\u4f30\u3002\u4e0e\u5bf9\u7167\u6216b1s1e2-Fc\u6cbb\u7597\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u63a5\u53d79d9\u6cbb\u7597\u7684\u5c0f\u9f20\u4e2dKi67+<\/sup>PD-1+<\/sup> CD4+<\/sup>\u548cCD8+<\/sup>\u6548\u5e94T\u7ec6\u80de\u4ee5\u53caKi67+<\/sup> Tregs\u7684\u9891\u7387\u589e\u52a0\uff0c\u8fd9\u8868\u660eCTLA-4\u62ee\u6297\u662f\u589e\u5f3aT\u7ec6\u80de\u542f\u52a8\u7684\u5fc5\u8981\u6761\u4ef6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u5bf9\u7167\u5c0f\u9f20\u4e2d\uff0c\u80bf\u7624\u4e2d\u7684Tregs\u7684CTLA-4+<\/sup> Tregs\u7684\u767e\u5206\u6bd4\u548cCTLA-4\u7684\u8868\u8fbe\u6c34\u5e73\u6bd4TDLN\u4e2d\u7684Tregs\u66f4\u9ad8\u3002\u7531\u4e8eTDLN\u4e2d\u7684Tregs\u5728\u8868\u9762\u4e0a\u7684CTLA-4\u6c34\u5e73\u4e0d\u8db3\u4ee5\u8bf1\u5bfc\u6d88\u8017\uff0c\u56e0\u6b64\u8fd9\u4e9bTregs\u7684\u6fc0\u6d3b\u662f9d9\u7684\u6cbb\u7597\u7ed3\u679c\u30029d9\u7684\u6cbb\u7597\u5bfc\u81f4TDLN\u4e2d\u7684Treg\u5728\u6cbb\u7597\u540e3\u5929\u5185\u6bd4\u6548\u5e94T\u7ec6\u80de\u6269\u589e\u5f97\u66f4\u591a\uff0c\u8fd9\u53ef\u80fd\u662f\u7531\u4e8eTregs\u7684CTLA-4\u8868\u8fbe\u6c34\u5e73\u9ad8\u4e8e\u6548\u5e94T\u7ec6\u80de\u3002\u7531\u4e8e\u8fd9\u53ef\u80fd\u4f1a\u6291\u5236\u4e00\u4e9b\u6548\u5e94T\u7ec6\u80de\u7684\u542f\u52a8\uff0c\u56e0\u6b64\u7814\u7a76\u4eba\u5458\u63a8\u6d4b\u9664\u4e86\u80bf\u7624Tregs\u5916\uff0c\u6d88\u8017TDLN Tregs\u53ef\u80fd\u4f1a\u63d0\u9ad8\u6548\u679c\u3002\u7814\u7a76\u4eba\u5458\u5229\u7528\u4e86Foxp3-DTR\u5c0f\u9f20\u6a21\u578b\u8fdb\u884c\u8bc4\u4f30\u3002\u8fd9\u4e2a\u6a21\u578b\u5141\u8bb8\u901a\u8fc7\u4f7f\u7528\u767d\u5589\u6bd2\u7d20\uff08DT\uff09\u8fdb\u884c\u9009\u62e9\u6027\u7684Treg\u6e05\u9664\u3002\u4f7f\u7528\u4f4e\u5242\u91cf\u7684IT DT\u7ed9\u836f\u8fdb\u884c\u5c40\u90e8Treg\u6d88\u8017\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5c40\u90e8Treg\u6d88\u8017\u5bfc\u81f4\u80bf\u7624\u5185\u6548\u5e94CD4+<\/sup> T\u7ec6\u80de\u7684\u589e\u52a0\uff0c\u4ee5\u53ca\u6548\u5e94CD8+<\/sup> T\u7ec6\u80de\u7684\u975e\u663e\u8457\u589e\u52a0\u3002TDLN\u4e2d\u7684CD4+<\/sup>\u6216CD8+<\/sup>\u6548\u5e94T\u7ec6\u80de\u7684\u9891\u7387\u6ca1\u6709\u5dee\u5f02\u3002\u4f7f\u7528\u8fd9\u79cd\u6a21\u578b\uff0c\u63a5\u79cdMC38\u6216B16F10\u80bf\u7624\u5e76\u4ece\u7b2c7\u5929\u5f00\u59cb\u4f7f\u7528DT\u8fdb\u884c\u6cbb\u7597\uff0c\u6bcf\u4e24\u5929\u7ed9\u836f\u4e00\u6b21\u4ee5\u7ef4\u6301\u80bf\u7624\u548cTDLN\u4e2d\u7684Treg\u6d88\u8017\uff0c\u5176\u751f\u5b58\u7387\u6bd4\u5bf9\u7167\u5c0f\u9f20\u6709\u6240\u63d0\u9ad8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u672c\u7814\u7a76\u4e2d\u7684\u6570\u636e\u8868\u660e\uff0cTreg\u6d88\u8017\u548cCTLA-4\u62ee\u6297\u5bf9\u4e8e\u8fd9\u79cd\u6cbb\u7597\u7684\u6548\u679c\u5747\u81f3\u5173\u91cd\u8981\u3002\u80bf\u7624\u548cTDLN\u4e2d\u7684Treg\u6d88\u8017\u53ef\u4ee5\u5bfc\u81f4T\u7ec6\u80de\u7684\u66f4\u6709\u6548\u542f\u52a8\uff1b\u7136\u800c\uff0c\u7531\u4e8eTDLN Tregs\u7684CTLA-4\u8868\u8fbe\u91cf\u4f4e\uff0c\u5f53\u524d\u9488\u5bf9CTLA-4\u7684\u4e34\u5e8a\u6297\u4f53\u5e76\u672a\u9488\u5bf9\u5b83\u4eec\u3002\u56e0\u6b64\uff0c\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u6697\u793a\uff0c\u8bf1\u5bfc\u8fd9\u4e9bTregs\u6d88\u8017\u7684\u65b0\u578b\u7597\u6cd5\u53ef\u80fd\u662f\u4e00\u79cd\u597d\u7684\u7ec4\u5408\u7b56\u7565\uff0c\u6709\u52a9\u4e8e\u63d0\u9ad8\u6297CTLA-4\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u4f5c\u8005\u9762\u5bf9\u9762<\/strong><\/p>\n<\/section>\n

\n
\n
\n

\u7b2c\u4e00\u4f5c\u8005Brianna M. Lax\u548c\u901a\u8baf\u4f5c\u8005K. Dane Wittrup\u56de\u7b54\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n
\n

Brianna M. Lax\u524d\u6392\u53f3\u6570\u7b2c\u4e8c\uff1bK. Dane Wittrup\u5750\u5728\u540e\u6392\u6700\u53f3\u8fb9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5bf9\u4f60\u6765\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u6700\u4ee4\u4eba\u60ca\u8bb6\u7684\u53d1\u73b0\u662f\u4ec0\u4e48?<\/strong><\/p>\n

\n
\n
\n

BML: <\/strong>\u5bf9\u6211\u6765\u8bf4\u6700\u4ee4\u4eba\u60ca\u8bb6\u7684\u53d1\u73b0\u4e4b\u4e00\u662f\uff0c\u4f7f\u7528\u767d\u5589\u6bd2\u7d20\u5728\u80bf\u7624\u5185\u548c\u6dcb\u5df4\u7ed3\u5185\u6d88\u8017Treg\u6bd4\u4f20\u7edf\u7684\u6297CTAL-4\u6297\u4f53\u66f4\u6709\u6548\u3002\u867d\u7136\u6211\u4eec\u53d1\u73b0\u6dcb\u5df4\u7ed3\u4e2d\u7684T\u7ec6\u80de\u542f\u52a8\u5bf9\u6cbb\u7597\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u6211\u6ca1\u60f3\u5230\u76f8\u5173\u7684\u6dcb\u5df4\u7ed3Treg\u589e\u6b96\u5982\u6b64\u6709\u5bb3\u3002\u767d\u5589\u6bd2\u7d20\u7684\u7814\u7a76\u8868\u660e\uff0c\u6dcb\u5df4\u7ed3\u4e2d\u7684Tregs\u5728\u6291\u5236\u514d\u75ab\u7cfb\u7edf\u65b9\u9762\u6709\u591a\u4e48\u5f3a\u5927\u3002<\/p>\n

KDW: <\/strong>\u6211\u5bf9\u6297CTLA-4\u6297\u4f53\u5bf9\u6dcb\u5df4\u7ed3\u4e2dTregs\u7684\u65e0\u6548\u6d88\u8017\u611f\u5230\u60ca\u8bb6\uff0c\u8fd9\u5f88\u53ef\u80fd\u662f\u7531\u4e8e\u4e0e\u80bf\u7624\u76f8\u6bd4\uff0c\u8be5\u533a\u57df\u4e2dCTLA-4\u7684\u8868\u9762\u6c34\u5e73\u8f83\u4f4e\u3002\u8003\u8651\u5230\u6dcb\u5df4\u7ed3\u9a7b\u7559Tregs\u5728\u6291\u5236CD8+<\/sup> T\u7ec6\u80de\u542f\u52a8\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u8fd9\u662f\u6709\u95ee\u9898\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u524d\u666f\u5982\u4f55?<\/strong><\/p>\n

\n
\n
\n

BML: <\/strong>\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u4e0b\u4e00\u4ee3\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u6709\u4ef7\u503c\u7684\u89c1\u89e3\u3002\u8fd9\u9879\u5de5\u4f5c\u652f\u6301\u5f00\u53d1\u5177\u6709\u589e\u5f3aTreg\u6d88\u8017\u80fd\u529b\u7684\u4eba\u7c7b\u6297CTLA-4\u6297\u4f53\uff0c\u540c\u65f6\u4e5f\u5f3a\u8c03\u4e86\u6d88\u8017\u6dcb\u5df4\u7ed3Treg\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u5e76\u4e3a\u5f00\u53d1\u80fd\u591f\u505a\u5230\u8fd9\u4e00\u70b9\u7684\u7597\u6cd5\u63d0\u4f9b\u4e86\u52a8\u529b\u3002<\/p>\n

KDW: <\/strong>\u6700\u540e\uff0cBri\u7684\u975e\u5e38\u9177\u7684\u975e\u7ade\u4e89\u6027CTLA-4\u7ed3\u5408\u7269\u5e76\u672a\u89e3\u51b3\u6dcb\u5df4\u7ed3Treg\u6d88\u8017\u7684\u96be\u9898\u3002\u7136\u800c\uff0c\u6211\u76f8\u4fe1\u5b83\u786e\u5b9e\u4e3a\u7406\u89e3CTLA-4\u914d\u4f53\u62ee\u6297\u4f5c\u7528\u548cTreg\u6d88\u8017\u5728\u6cbb\u7597\u6548\u679c\u4e2d\u7684\u590d\u6742\u9700\u6c42\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\uff0c\u56e0\u6b64\uff0c\u5b83\u53ef\u80fd\u4f1a\u5e2e\u52a9\u672a\u6765\u7684\u6297\u4f53\u5f00\u53d1\u8005\u6784\u601d\u51fa\u66ff\u4ee3\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u4f60\u6700\u8fd1\u5728\u5de5\u4f5c\u4e4b\u5916\u5b66\u5230\u7684\u6700\u9177\u7684\u4e8b\u60c5\u662f\u4ec0\u4e48?<\/strong><\/p>\n

\n
\n
\n

BML: <\/strong>\u6211\u6700\u8fd1\u53bb\u4e86\u58a8\u897f\u54e5\u7684\u74e6\u54c8\u5361\uff0c\u5e76\u5728Chacahua\u56fd\u5bb6\u516c\u56ed\u7684\u53d1\u5149\u7684\u6cfb\u6e56\u4e2d\u6e38\u6cf3\u3002\u5728\u90a3\u91cc\uff0c\u6211\u4e86\u89e3\u5230\u8fd9\u4e9b\u795e\u5947\u7684\u6d6e\u6e38\u751f\u7269\u53ea\u80fd\u751f\u6d3b\u572870%\u7684\u76d0\u6c34\u548c30%\u7684\u6de1\u6c34\u5f62\u6210\u7684\u534a\u54b8\u6c34\u4e2d\u3002\u8fd9\u4e9b\u751f\u7269\u5229\u7528\u8367\u5149\u9176\u50ac\u5316\u6c27\u5316\u53cd\u5e94\uff0c\u4ee5\u7ea698%\u7684\u60ca\u4eba\u6548\u7387\u91ca\u653e\u5149\u7ebf\uff01\u8fd9\u4e9b\u751f\u7269\u6b63\u5728\u8bc1\u660e\uff0c\u9176\u662f\u90a3\u4e9b\u6700\u9177\u7684\u86cb\u767d\u8d28\u3002<\/p>\n

KDW: <\/strong>\u4f69\u6234Fitbit\u56db\u4e2a\u6708\u7684\u7ecf\u9a8c\u544a\u8bc9\u6211\uff0c\u6211\u5e76\u6ca1\u6709\u6211\u4ee5\u4e3a\u7684\u90a3\u4e48\u81ea\u5f8b\u3002\u6211\u6ca1\u6709\u6539\u53d8\u6211\u5047\u8bbe\u7684\u953b\u70bc\u8ba1\u5212\uff0c\u53ea\u662f\u8ba9\u8fd9\u4e2a\u4e13\u5236\u7684\u624b\u8868\u7f9e\u8fb1\u6211\u4ee5\u8fbe\u5230\u5168\u9762\u9075\u5b88\uff0c\u7ed3\u679c\u6211\u7684\u8840\u538b\u548c\u9759\u606f\u5fc3\u7387\u90fd\u6709\u6240\u6539\u5584\u3002\uff08\u6211\u60f3\u8fd9\u5c31\u662f\u4e00\u4e2a60\u5c81\u7684\u6559\u6388\u4e0e\u6e38\u6cf3\u4e0e\u795e\u5947\u7684\u6d6e\u6e38\u751f\u7269\u76f8\u6bd4\uff0c\u66f4\u4e3a\u5174\u594b\u7684\u4e8b\u60c5\u3002\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & PNAS<\/span><\/section>\n
\u7ffb\u8bd1\u6574\u7406 | \u5ed6\u5a9b \u738b\u5764<\/span><\/span><\/span><\/section>\n
\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762
<\/span><\/span><\/section>\n
\u516c\u4f17\u53f7\u53d1\u9001202300809\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n

<\/span><\/strong><\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6297CTLA-4\u7597\u6cd5\u7684\u4f5c\u7528\u673a\u5236\u4ecd\u7136\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u6709\u5047\u8bbe\u8ba4\u4e3a\u5176\u7597\u6548\u53ef\u80fd\u6e90\u81eaCTLA-4:B7\u7ed3\u5408\u7684\u62ee\u6297\u4f5c\u7528\u6216\u662f\u901a\u8fc7F…<\/p>\n","protected":false},"author":1,"featured_media":3153,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[76],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3156"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3156"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3156\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3153"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3156"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3156"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}