{"id":3159,"date":"2023-09-28T21:33:05","date_gmt":"2023-09-28T13:33:05","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/09\/28\/nat-cancer-20230830-il-2r%ce%b1%e9%80%89%e6%8b%a9%e6%80%a7%e6%bf%80%e6%b4%bb%e9%80%9a%e8%bf%87%e5%88%ba%e6%bf%80%e8%82%bf%e7%98%a4%e6%b5%b8%e6%b6%a6%e6%80%a7cd25cd8-t%e7%bb%86%e8%83%9e%e5%a2%9e\/"},"modified":"2023-09-28T21:33:05","modified_gmt":"2023-09-28T13:33:05","slug":"nat-cancer-20230830-il-2r%ce%b1%e9%80%89%e6%8b%a9%e6%80%a7%e6%bf%80%e6%b4%bb%e9%80%9a%e8%bf%87%e5%88%ba%e6%bf%80%e8%82%bf%e7%98%a4%e6%b5%b8%e6%b6%a6%e6%80%a7cd25cd8-t%e7%bb%86%e8%83%9e%e5%a2%9e","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/09\/28\/nat-cancer-20230830-il-2r%ce%b1%e9%80%89%e6%8b%a9%e6%80%a7%e6%bf%80%e6%b4%bb%e9%80%9a%e8%bf%87%e5%88%ba%e6%bf%80%e8%82%bf%e7%98%a4%e6%b5%b8%e6%b6%a6%e6%80%a7cd25cd8-t%e7%bb%86%e8%83%9e%e5%a2%9e\/","title":{"rendered":"Nat Cancer. 20230830: IL-2R\u03b1\u9009\u62e9\u6027\u6fc0\u6d3b\u901a\u8fc7\u523a\u6fc0\u80bf\u7624\u6d78\u6da6\u6027CD25+CD8+ T\u7ec6\u80de\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab"},"content":{"rendered":"<div class='wxsyncmain'>\n<section style=\"font-size: 16px;\">\n<section style=\"line-height: 0;\" powered-by=\"xiumi.us\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-ratio=\"0.7685185185185185\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-986aaee39c41776f56ee02bd57bb0316.png\"  \/><\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u6700\u8fd1\u5bf9IL-2\u6cbb\u7597\u7b56\u7565\u7684\u8fdb\u5c55\u5bfc\u81f4\u4e86IL-2R\u03b2\u03b3\u9009\u62e9\u6027\u6fc0\u6d3b\u7597\u6cd5\u7684\u53d1\u5c55\uff0c\u9884\u671f\u6bd2\u6027\u66f4\u4f4e\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u4ee4\u4eba\u5931\u671b\u3002Wu\u3001Chia\u7b49\u4eba\u8bc4\u4f30\u4e86\u5404\u79cd\u5f62\u5f0f\u7684IL-2\u7684\u4f5c\u7528\u65b9\u5f0f\uff0c\u4ee5\u5e2e\u52a9\u672a\u6765\u8bbe\u8ba1IL-2\u6cbb\u7597\u65b9\u6848\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u6700\u8fd1\u53d1\u8868\u5728\u300aNature Cancer\u300b\u6742\u5fd7\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4e3a\u4e86\u7814\u7a76\u4e0d\u540c\u5f62\u5f0f\u7684IL-2\u6cbb\u7597\u7684\u4f5c\u7528\u65b9\u5f0f\uff0c\u7814\u7a76\u4eba\u5458\u6d4b\u8bd5\u4e86\u4eba\u6e90IL-2<sup>wt<\/sup>\u548cIL-2<sup>n\u03b1<\/sup>\uff08\u5e26\u6709\u7834\u574fIL-2R\u03b1\u7684\u7a81\u53d8\uff0c\u5bfc\u81f4\u4e86\u5bf9IL-2R\u03b2\u03b3\u504f\u5411\u7684IL-2\u7c7b\u4f3c\u7269\uff09\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cIL-2<sup>wt<\/sup>\u6bd4IL-2<sup>n\u03b1<\/sup>\u66f4\u6709\u6548\u5730\u6fc0\u6d3b\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\uff0c\u800c\u4e24\u79cd\u5f62\u5f0f\u7684IL-2\u5bf9\u9759\u606f\u72b6\u6001\u7684CD8<sup>+<\/sup> T\u7ec6\u80de\u3001CD4<sup>+<\/sup>CD25<sup>&#8211;<\/sup> T\u7ec6\u80de\u548cNK\u7ec6\u80de\uff08\u5b83\u4eec\u90fd\u8868\u8fbeIL-2R\u03b2\u03b3\uff09\u7684\u6d3b\u6027\u76f8\u4f3c\u3002\u7136\u800c\uff0c\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0c\u4e0eIL-2<sup>n\u03b1<\/sup>\u76f8\u6bd4\uff0cIL-2<sup>wt<\/sup>\u5177\u6709\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u529f\u6548\uff0c\u5e76\u5bfc\u81f4\u66f4\u4f4e\u7684\u4f53\u91cd\u635f\u5931\u548c\u8f83\u5c11\u7684\u6b7b\u4ea1\u3002\u8fd9\u4ee4\u4eba\u60ca\u8bb6\uff0c\u56e0\u4e3a\u5148\u524d\u7684\u6570\u636e\u8868\u660e\uff0cIL-2<sup>wt<\/sup>\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u4f1a\u504f\u5411\u6fc0\u6d3bTregs\uff0c\u5bfc\u81f4\u514d\u75ab\u6291\u5236\uff0c\u5e76\u4e14\u4e0e\u5185\u76ae\u7ec6\u80de\u4e0a\u7684IL-2R\u03b1\u7ed3\u5408\u4f1a\u5bfc\u81f4\u6bd2\u6027\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u5728\u80bf\u7624\u548c\u5916\u5468\u7ec4\u7ec7\u4e2d\uff0cIL-2<sup>n\u03b1<\/sup>\u6cbb\u7597\u5bfc\u81f4\u4e86\u8f83\u9ad8\u7684CD8<sup>+<\/sup> T\u7ec6\u80de\u4e0eTreg\u7684\u6bd4\u503c\uff0c\u800cIL-2<sup>wt<\/sup>\u5219\u8f83\u4f4e\u3002\u7136\u800c\uff0cCD8<sup>+<\/sup> T\u7ec6\u80de\u6570\u91cf\u7684\u589e\u52a0\u5e76\u6ca1\u6709\u5bfc\u81f4\u66f4\u597d\u7684\u6297\u80bf\u7624\u53cd\u5e94\u3002\u7531\u4e8e\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u53ef\u4ee5\u662f\u80bf\u7624\u6297\u539f\u7279\u5f02\u6027\u6548\u5e94T\u7ec6\u80de\uff08TST\uff09\u548c\u4e0e\u80bf\u7624\u65e0\u5173\u7684\u65c1\u89c2\u8005T\u7ec6\u80de\uff0c\u8fd9\u4e9b\u4e0d\u540c\u7684IL-2\u5f62\u5f0f\u53ef\u80fd\u5728\u6fc0\u6d3bTST\u548c\u65c1\u89c2\u8005\u7ec6\u80de\u65b9\u9762\u5b58\u5728\u5dee\u5f02\u3002\u7814\u7a76\u53d1\u73b0\uff0cIL-2<sup>wt<\/sup>\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6269\u589e\u4e86\u66f4\u591a\u7684CD39<sup>+<\/sup>CD8<sup>+<\/sup> T\u7ec6\u80de\u6216p15E-tetramer<sup>+<\/sup>CD8<sup>+<\/sup> T\u7ec6\u80de\uff0c\u800cIL-2<sup>n\u03b1<\/sup>\u5219\u6269\u589e\u4e86CD39<sup>&#8211;<\/sup>PD-1<sup>&#8211;<\/sup>\u7684\u65c1\u89c2\u8005\u7ec6\u80de\u3002TST\u7ec6\u80de\u8868\u8fbe\u8f83\u9ad8\u6c34\u5e73\u7684CD25\uff0c\u6bd4\u65c1\u89c2\u8005\u7ec6\u80de\u66f4\u5bb9\u6613\u88abIL-2<sup>wt<\/sup>\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u63a5\u53d7\u8fd9\u4e24\u79cdIL-2\u6cbb\u7597\u7684\u80bf\u7624\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u4e86\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff08scRNAseq\uff09\u3002\u805a\u7126\u4e8eT\u7ec6\u80de\u7fa4\u4f53\uff0c\u53ef\u4ee5\u89c2\u5bdf\u5230\u516b\u4e2a\u4e9a\u7fa4\u3002IL-2<sup>wt<\/sup>\u589e\u52a0\u4e86\u6fc0\u6d3b\u7684CD8<sup>+<\/sup> T\u7ec6\u80de\u548c\u4f20\u7edf\u7684CD4<sup>+<\/sup> T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u800cIL-2<sup>n\u03b1<\/sup>\u6269\u589e\u4e86\u5e7c\u7a1a\u7684CD8<sup>+<\/sup> T\u7ec6\u80de\u3002\u4e24\u79cd\u6cbb\u7597\u65b9\u6cd5\u90fd\u964d\u4f4e\u4e86Tregs\u7684\u6bd4\u4f8b\uff0c\u4f46\u5728IL-2<sup>n\u03b1<\/sup>\u7ec4\u4e2d\u8fd9\u79cd\u60c5\u51b5\u66f4\u4e3a\u660e\u663e\u3002\u8f68\u8ff9\u548c\u57fa\u56e0\u8868\u8fbe\u5206\u6790\u663e\u793a\uff0cIL-2<sup>wt<\/sup>\u523a\u6fc0\u4e86CD8<sup>+<\/sup> T\u7ec6\u80de\u5411\u66f4\u6fc0\u6d3b\u3001\u6548\u5e94\u548c\u8017\u7aed\u72b6\u6001\u7684\u5206\u5316\uff0c\u800cIL-2<sup>n\u03b1<\/sup>\u4fdd\u6301\u4e86\u8f83\u4e0d\u6fc0\u6d3b\u548c\u5e7c\u7a1a\u7684T\u7ec6\u80de\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u521b\u5efa\u4e86\u9009\u62e9\u6027\u6fc0\u6d3bIL-2\u03b1\u7684\u6784\u5efa\u7269\uff0c\u5176\u4e2d\u4e2d\u65ad\u4e86IL-2\u4e0eIL-2R\u03b2\u7684\u7ed3\u5408\u3002\u8be5\u6784\u5efa\u7269\u53ef\u4ee5\u4e0eIL-2R\u03b1\u7ed3\u5408\uff0c\u5e76\u4e14\u53ea\u5bf9\u8868\u8fbeCD25\u7684T\u7ec6\u80de\u5177\u6709\u6d3b\u6027\u3002\u4e3a\u4e86\u6d4b\u8bd5\u9009\u62e9\u6027\u6fc0\u6d3bCD25<sup>+<\/sup>CD8<sup>+<\/sup>\u6548\u5e94T\u7ec6\u80de\u662f\u5426\u8db3\u4ee5\u53d1\u6325\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528IL-2\u03b1\u9009\u62e9\u6027\u6fc0\u6d3b\u6cbb\u7597\u643a\u5e26MC38\u80bf\u7624\u7684\u5c0f\u9f20\u3002\u6cbb\u7597\u6709\u6548\u6291\u5236\u4e86\u80bf\u7624\u7684\u751f\u957f\uff0c\u5728B16F10-OVA\u80bf\u7624\u4e2d\u589e\u52a0\u4e86OVA-tetramer<sup>+<\/sup>CD8<sup>+<\/sup>\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u7684\u6bd4\u4f8b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86IL-2\u03b1\u9009\u62e9\u6027\u6cbb\u7597\u5bf9Treg\u7fa4\u4f53\u7684\u5f71\u54cd\u3002\u5728\u5916\u5468\u8840\u6db2\u4e2d\uff0c\u6cbb\u7597\u589e\u52a0\u4e86Tregs\u7684\u6bd4\u4f8b\uff0c\u5e76\u4e0b\u8c03\u4e86CD8<sup>+<\/sup> T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002\u7136\u800c\uff0c\u5728\u80bf\u7624\u4e2d\u89c2\u5bdf\u5230\u76f8\u53cd\u7684\u8d8b\u52bf\uff0cCD8<sup>+<\/sup> T\u7ec6\u80de\u7684\u6bd4\u4f8b\u589e\u52a0\uff0c\u800cTregs\u7684\u6bd4\u4f8b\u4e0b\u964d\uff0c\u8fd9\u8868\u660eIL-2\u03b1\u9009\u62e9\u6027\u6cbb\u7597\u7684\u6548\u5e94\u662f\u4f9d\u8d56\u4e8e\u73af\u5883\u80cc\u666f\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u9274\u4e8eCD25\u548cPD-1\u7684\u8868\u8fbe\u53d7TCR\u4fe1\u53f7\u4f20\u5bfc\u8c03\u63a7\uff0c\u7814\u7a76\u4eba\u5458\u5047\u8bbe\u4e00\u90e8\u5206\u7ecf\u5386\u4e86\u80bf\u7624\u6297\u539f\u523a\u6fc0\u7684CD8<sup>+<\/sup>\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u5171\u8868\u8fbeCD25\u548cPD-1\uff0c\u5e76\u4e14\u4f5c\u4e3a\u4e3b\u8981\u7684\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u3002\u5728MC38\u80bf\u7624\u7684CD8<sup>+<\/sup> TILs\u4e2d\uff0c\u5927\u90e8\u5206\u8868\u8fbeCD25\u7684\u7ec6\u80de\u4e5f\u8868\u8fbePD-1\uff0c\u800c\u5728\u813e\u810f\u4e2d\u51e0\u4e4e\u6ca1\u6709PD-1<sup>+<\/sup>CD25<sup>+<\/sup>CD8<sup>+<\/sup> T\u7ec6\u80de\u3002\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\uff0cPD-1<sup>+<\/sup>CD25<sup>+<\/sup>\u7ec6\u80de\u5728\u603bCD8<sup>+<\/sup> TIL\u4eba\u7fa4\u4e2d\u7684\u767e\u5206\u6bd4\u6709\u6240\u4e0d\u540c\u3002\u76f8\u5bf9\u4e8eTIL\u8f83\u5c11\u7684\u80bf\u7624\uff0c\u5177\u6709\u8f83\u9ad8CD8<sup>+<\/sup> T\u7ec6\u80de\u6d78\u6da6\uff08MC38\u3001B16F10\u548cCT26\uff09\u7684\u80bf\u7624\u5bf9IL-2\u03b1\u504f\u5411\u6cbb\u7597\u7684\u53cd\u5e94\u66f4\u597d\uff0c\u5e76\u4e14PD-1<sup>+<\/sup>CD25<sup>+<\/sup>\u548cCD25<sup>+<\/sup>\u7ec6\u80de\u5728CD8<sup>+<\/sup> TILs\u4e2d\u7684\u767e\u5206\u6bd4\u4e0e\u8fd9\u4e9b\u6a21\u578b\u4e2d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4e3a\u4e86\u8bc4\u4f30PD-1<sup>+<\/sup>CD25<sup>+<\/sup>CD8<sup>+<\/sup> TIL\u4e9a\u7fa4\u662f\u5426\u4e5f\u5b58\u5728\u4e8e\u4eba\u7c7b\u80bf\u7624\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u6bd4\u8f83\u4e86\u6765\u81ea14\u4e2a\u80bf\u7624\u6837\u672c\u548c\u76f8\u5e94\u6b63\u5e38\u7ec4\u7ec7\u7684CD8<sup>+<\/sup> T\u7ec6\u80de\u7684\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u6570\u636e\u3002\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\uff0cPD-1\u548cCD25\u7684\u5171\u8868\u8fbe\u5728\u6240\u6709CD8<sup>+<\/sup> TIL\u4e2d\u68c0\u6d4b\u5230\u7684\u6bd4\u4f8b\u4e3a0.2-5.2%\uff0c\u800c\u8fd9\u4e9b\u7ec6\u80de\u5728\u80bf\u7624\u4e2d\u6bd4\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u66f4\u4e3a\u5e38\u89c1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4e3a\u4e86\u786e\u5b9a\u6297PD-1\u6cbb\u7597\u5982\u4f55\u5f71\u54cdIL-2\u4fe1\u53f7\u4f20\u5bfc\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u884c\u4e86\u4eba\u7c7bT\u7ec6\u80de\u7684\u4f53\u5916\u5b9e\u9a8c\u3002\u6297PD-1\u6cbb\u7597\u5bfc\u81f4\u4e86\u53d7\u523a\u6fc0\u7684T\u7ec6\u80de\u4ea7\u751fIL-2\u7684\u589e\u52a0\uff0c\u5176\u4e2d\u4e3b\u8981\u6765\u81eaPD-1<sup>+<\/sup>CD25<sup>+<\/sup>CD8<sup>+<\/sup>\u4e9a\u7fa4\u3002\u56de\u5230\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\uff0c\u5728MC38\u80bf\u7624\u4e2d\uff0c\u6297PD-1\u6cbb\u7597\u523a\u6fc0\u4e86CD25<sup>+<\/sup>PD-1<sup>+<\/sup>\u548cCD25<sup>+<\/sup>PD-1<sup>&#8211;<\/sup>CD8<sup>+<\/sup> T\u7ec6\u80de\u4e9a\u7fa4\u4e2d\u7684IL-2\u4ea7\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4e3a\u4e86\u8fdb\u4e00\u6b65\u7814\u7a76IL-2\u5982\u4f55\u5f71\u54cd\u5bf9\u6297PD-1\u6cbb\u7597\u7684\u53cd\u5e94\uff0c\u5434\u6559\u6388\u3001Chia\u6559\u6388\u7b49\u4eba\u91cd\u65b0\u5206\u6790\u4e86\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u751f\u7269\u6807\u5fd7\u7269\u548c\u7597\u6548\u6570\u636e\u3002\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u63a5\u53d7\u6297PD-1\u6297\u4f53sintilimab\u8054\u5408\u57f9\u7f8e\u66f2\u585e\u548c\u94c2\u7c7b\uff08\u5316\u7597\uff09\u7684\u6cbb\u7597\u3002\u5728\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0cIL-2\u9014\u5f84\u7684\u6807\u5fd7\u7269\u4e0e\u80bf\u7624\u53cd\u5e94\u4e4b\u95f4\u5b58\u5728\u5f3a\u70c8\u7684\u6b63\u76f8\u5173\u6027\uff0c\u5177\u6709\u8f83\u9ad8\u6807\u5fd7\u7269\u7684\u60a3\u8005\u5177\u6709\u66f4\u597d\u7684\u53cd\u5e94\u548c\u6539\u5584\u7684\u751f\u5b58\u7387\u3002\u8fd9\u4e9b\u7ed3\u679c\u5728\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u8bc1\u5b9e\uff0c\u8be5\u7814\u7a76\u4f7f\u7528\u4e86\u63a5\u53d7\u5404\u79cd\u6297PD-1\u6297\u4f53\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u6570\u636e\u3002\u56e0\u6b64\uff0cIL-2\u7279\u5f81\u53ef\u80fd\u53ef\u4ee5\u4f5c\u4e3aPD-1\u9776\u5411\u6cbb\u7597\u7684\u6cbb\u7597\u53cd\u5e94\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u4e3a\u4e86\u8bc4\u4f30IL-2\u6807\u5fd7\u7269\u5728\u5904\u4e8e\u8017\u7aed\u72b6\u6001\u7684\u80bf\u7624\u4e2d\u7684\u6548\u5e94\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u5177\u6709\u4e0d\u540c\u8017\u7aed\u72b6\u6001\u7684\u5c0f\u9f20\u6a21\u578b\u3002\u5728\u5177\u6709\u5c0f\u578b\u3001\u8f83\u5c11\u8017\u7aed\u7684\u80bf\u7624\u7684\u5c0f\u9f20\u4e2d\uff0c\u6297PD-1\u6cbb\u7597\u5bfc\u81f4\u80bf\u7624\u6d88\u9000\uff0c\u800c\u5728\u5177\u6709\u660e\u663e\u529f\u80fd\u5931\u8c03\u72b6\u6001\u7684\u8f83\u5927\u7684\u80bf\u7624\u4e2d\uff0c\u6548\u679c\u6709\u9650\u3002\u6279\u91cfRNA\u6d4b\u5e8f\u663e\u793a\uff0c\u4e0e\u5927\u578b\u80bf\u7624\u76f8\u6bd4\uff0c\u5c0f\u578b\u80bf\u7624\u5177\u6709\u66f4\u9ad8\u7684IL-2\u9014\u5f84\u6fc0\u6d3b\u3001IFN\u03b3\u53cd\u5e94\u548cCD8<sup>+<\/sup>TCR\u6fc0\u6d3b\u6807\u5fd7\u7269\u3002\u5728TIL\u8017\u7aed\u7684MC38\u548cTIL\u6392\u65a5\u7684EMT6\u5927\u578b\u80bf\u7624\u6a21\u578b\u4e2d\uff0cIL-2\u03b1\u504f\u5411\u6027\u6cbb\u7597\u4e0e\u6297PD-1\u8054\u5408\u4f7f\u7528\u5177\u6709\u534f\u540c\u6548\u5e94\uff0c\u5bfc\u81f4\u5927\u591a\u6570\u80bf\u7624\u7684\u6839\u9664\uff0c\u957f\u671f\u751f\u5b58\uff0c\u5e76\u5bf9\u80bf\u7624\u518d\u6311\u6218\u63d0\u4f9b\u4fdd\u62a4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\" powered-by=\"xiumi.us\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);box-shadow: rgb(170, 170, 170) 0px 0px 6px 0px;border-radius: 5px;overflow: hidden;\">\n<section style=\"color: rgb(51, 51, 51);\" powered-by=\"xiumi.us\">\n<p style=\"white-space: normal;\">\u8fd9\u9879\u7814\u7a76\u8868\u660e\uff0c\u901a\u8fc7\u9776\u5411CD25\u7684IL-2\u53ef\u4ee5\u7279\u5f02\u6027\u5730\u6fc0\u6d3b\u4e0e\u80bf\u7624\u53cd\u5e94\u76f8\u5173\u7684T\u7ec6\u80de\uff0c\u800c\u4e0d\u662f\u589e\u52a0\u80bf\u7624\u4e2d\u65c1\u89c2\u8005T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u5e76\u4e14\u8be5\u6cbb\u7597\u53ef\u4e0e\u6297PD-1\u6cbb\u7597\u53d1\u6325\u534f\u540c\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u6570\u636e\u53ef\u4ee5\u4e3a\u5f00\u53d1\u66f4\u6709\u6548\u7684IL-2\u6cbb\u7597\u65b9\u6848\u63d0\u4f9b\u6307\u5bfc\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 12px;\">\u2014 THE &nbsp;END \u2014<\/span><\/section>\n<section style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u6765\u6e90&nbsp;| ACIR.ORG&nbsp;&amp; Nat Cancer.<\/span><\/section>\n<section style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\">\u7ffb\u8bd1\u6574\u7406<span style=\"outline: 0px;letter-spacing: 0.544px;\">&nbsp;| \u4f55\u4e3d\u5a1c&nbsp;\u738b\u5764<\/span><\/span><\/span><\/section>\n<section style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\">\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762<br style=\"outline: 0px;\"  \/><\/span><\/span><\/section>\n<section style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;color: rgb(34, 34, 34);font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\"><span style=\"outline: 0px;color: rgb(255, 0, 0);letter-spacing: 0.544px;\">\u516c\u4f17\u53f7\u53d1\u9001202300830\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n<p style=\"margin-bottom: 0px;outline: 0px;letter-spacing: 0.544px;white-space: normal;color: rgb(53, 53, 53);font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;background-color: rgb(255, 255, 255);line-height: 1.6em;\"><strong style=\"outline: 0px;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><\/span><\/strong><\/p>\n<p style=\"outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);\"><br style=\"outline: 0px;\"  \/><\/p>\n<section style=\"margin-bottom: 8px;outline: 0px;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);\"><strong style=\"outline: 0px;font-size: 16px;text-indent: 0em;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;letter-spacing: 0.54px;text-align: center;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(64, 118, 0);font-family: Arial, sans-serif;letter-spacing: 2px;visibility: visible;\">\u2589&nbsp; \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n<section style=\"outline: 0px;letter-spacing: 0.544px;white-space: normal;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 16px;background-color: rgb(255, 255, 255);visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"margin-top: 24px;outline: 0px;visibility: visible;\"><strong style=\"outline: 0px;text-indent: 0em;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;letter-spacing: 0.54px;text-align: center;visibility: visible;\"><strong style=\"outline: 0px;color: rgb(64, 118, 0);font-family: Arial, sans-serif;letter-spacing: 2px;visibility: visible;\"><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"margin-bottom: 0em;outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;line-height: 2em;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;text-align: center;justify-content: center;display: flex;flex-flow: row nowrap;visibility: visible;\">\n<section style=\"padding: 29px;outline: 0px;display: inline-block;width: 677px;vertical-align: top;background-color: rgba(97, 155, 139, 0.09);align-self: flex-start;flex: 0 0 auto;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;visibility: visible;\">\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2826543872209125379&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;color: var(--weui-LINK);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;cursor: pointer;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=MzAwMDUzNTIxNA==&amp;action=getalbum&amp;album_id=1647467076418060289#wechat_redirect\" textvalue=\"\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener\">\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2018077716062715908&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2822922341205737475&amp;count=3#wechat_redirect\" textvalue=\"ACIR\u6587\u732e\u901f\u9012\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564295698236358662&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u4f5c\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564293167342993409&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1894714083283615746&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456254175&amp;idx=1&amp;sn=d302a786f8fea3868ee719195418af61&amp;scene=21#wechat_redirect\" textvalue=\"R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564291300860936193&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;color: var(--weui-LINK);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;cursor: pointer;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564278007870046209&amp;count=3#wechat_redirect\" textvalue=\"RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener\">RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564286064490496000&amp;count=3#wechat_redirect\" textvalue=\"\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener\">\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"162\" data-cropsely1=\"0\" data-cropsely2=\"162\" data-fileid=\"308764751\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"jpeg\" data-w=\"258\" style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 14px;letter-spacing: 0.54px;display: initial;visibility: visible !important;width: 162px !important;\" width=\"162px\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-37436bfb03f3af56c2d9d1f15d025bb9.jpeg\"  \/><\/span><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u5173\u6ce8\u672c\u53f7~<\/span><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"155\" data-cropsely1=\"0\" data-cropsely2=\"155\" data-fileid=\"308764752\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"jpeg\" data-w=\"613\" style=\"outline: 0px;display: initial;visibility: visible !important;width: 147px !important;\" width=\"147px\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-31c5899f9f8bf52a8d71c2727d9fa17d.jpeg\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n<p style=\"outline: 0px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"margin-bottom: 0em;outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><img decoding=\"async\" class=\"rich_pages wxw-img\" data-cropselx1=\"0\" data-cropselx2=\"147\" data-cropsely1=\"0\" data-cropsely2=\"147\" data-fileid=\"308764752\" data-ratio=\"1\" data-s=\"300,640\"  data-type=\"png\" data-w=\"400\" style=\"outline: 0px;display: initial;visibility: visible !important;width: 172px !important;\" width=\"172px\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2023\/10\/wxsync-2023-10-19b3b83ce1f57adda5547d3f49a89758.png\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br style=\"outline: 0px;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span style=\"outline: 0px;font-size: 15px;background-color: rgb(249, 237, 166);\">\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span style=\"outline: 0px;font-size: 15px;background-color: rgb(249, 237, 166);\">\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<blockquote>\n<p>\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:                 OncoLab              <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\u5bf9IL-2\u6cbb\u7597\u7b56\u7565\u7684\u8fdb\u5c55\u5bfc\u81f4\u4e86IL-2R\u03b2\u03b3\u9009\u62e9\u6027\u6fc0\u6d3b\u7597\u6cd5\u7684\u53d1\u5c55\uff0c\u9884\u671f\u6bd2\u6027\u66f4\u4f4e\u3002\u7136\u800c\uff0c\u6700\u8fd1\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u4ee4&hellip;<\/p>\n","protected":false},"author":1,"featured_media":3157,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[76],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3159"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3159"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3157"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3159"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}