{"id":3167,"date":"2023-10-04T20:29:02","date_gmt":"2023-10-04T12:29:02","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/10\/04\/science-immunology-%e8%80%97%e7%ab%ad%e4%bd%86%e4%bb%8d%e6%9c%89%e6%b4%bb%e6%80%a7%ef%bc%9ahnscc%e4%b8%adtil%e8%80%97%e7%ab%ad%e5%9e%8b%e4%ba%9a%e7%be%a4%e5%af%b9%e6%8a%97pd-1%e6%b2%bb%e7%96%97\/"},"modified":"2023-10-04T20:29:02","modified_gmt":"2023-10-04T12:29:02","slug":"science-immunology-%e8%80%97%e7%ab%ad%e4%bd%86%e4%bb%8d%e6%9c%89%e6%b4%bb%e6%80%a7%ef%bc%9ahnscc%e4%b8%adtil%e8%80%97%e7%ab%ad%e5%9e%8b%e4%ba%9a%e7%be%a4%e5%af%b9%e6%8a%97pd-1%e6%b2%bb%e7%96%97","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/10\/04\/science-immunology-%e8%80%97%e7%ab%ad%e4%bd%86%e4%bb%8d%e6%9c%89%e6%b4%bb%e6%80%a7%ef%bc%9ahnscc%e4%b8%adtil%e8%80%97%e7%ab%ad%e5%9e%8b%e4%ba%9a%e7%be%a4%e5%af%b9%e6%8a%97pd-1%e6%b2%bb%e7%96%97\/","title":{"rendered":"Science Immunology | \u8017\u7aed\u4f46\u4ecd\u6709\u6d3b\u6027\uff1aHNSCC\u4e2dTIL\u8017\u7aed\u578b\u4e9a\u7fa4\u5bf9\u6297PD-1\u6cbb\u7597\u4ea7\u751f\u53cd\u5e94"},"content":{"rendered":"
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\u672c\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9776\u5411PD-1\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\uff08ICB\uff09\u65e5\u76ca\u88ab\u7528\u4f5c\u65b0\u8f85\u52a9\u7597\u6cd5\u3002\u7136\u800c\uff0c\u51b3\u5b9aICB\u53cd\u5e94\u7684\u673a\u5236\u548c\u7ec6\u80de\u7c7b\u578b\u4ecd\u7136\u77e5\u4e4b\u751a\u5c11\u3002Oliveira\uff0cEgloff\uff0cAfeyan\u7b49\u4eba\u6bd4\u8f83\u4e86\u5934\u9888\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u60a3\u8005\u5728\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u4e0b\u7684T\u7ec6\u80de\u6fc0\u6d3b\u72b6\u6001\u548c\u52a8\u6001\uff0c\u5e76\u5206\u522b\u5bf9\u5e94\u7b54\u8005\u548c\u975e\u5e94\u7b54\u8005\u8fdb\u884c\u4e86\u6bd4\u8f83\uff0c\u6700\u8fd1\u4ed6\u4eec\u5728\u300aScience Immunology<\/em>\u300b\u4e0a\u53d1\u8868\u4e86\u4ed6\u4eec\u7684\u6570\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u9879\u7814\u7a76\u7684\u6837\u672c\u6765\u81ea30\u4f4d\u53c2\u52a0\u4e8c\u671f\u8bd5\u9a8c\u7684HPV\u65e0\u5173HNSCC\u60a3\u8005\uff0c\u4ed6\u4eec\u5728\u624b\u672f\u524d\u63a5\u53d7\u4e86\u4e24\u5242\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u3002\u572815\u4f4d\u60a3\u8005\uff0852%\uff09\u4e2d\u68c0\u6d4b\u5230\u75c5\u7406\u6027\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u786e\u5b9a\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684T\u7ec6\u80de\u52a8\u6001\u5982\u4f55\u4e0e\u5bf9\u6d3e\u59c6\u5355\u6297\u7684\u53cd\u5e94\u76f8\u5173\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u6765\u81ea14\u4e2a\u80bf\u7624\u6d3b\u68c0\u6837\u672c\u7684CD3+<\/sup> TIL\u8fdb\u884c\u4e86\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\u548cTCR\u6d4b\u5e8f\uff0c\u8fd9\u4e9b\u6837\u672c\u5728\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u524d\u548c\/\u6216\u540e\u6536\u96c6\u3002\u5206\u6790\u4e86\u4e03\u4f4d\u63a5\u53d7\u4e86\u4e24\u5242\u6cbb\u7597\u548c\u4e00\u4f4d\u63a5\u53d7\u4e86\u4e00\u5242\u6cbb\u7597\u7684\u60a3\u8005\u7684\u6837\u672c\uff1b\u5176\u4e2d\u56db\u4f4d\u60a3\u8005\u662f\u5e94\u7b54\u8005\u3002\u6765\u81ea6\u4f4d\u60a3\u8005\uff083\u4f4d\u5e94\u7b54\u8005\u548c3\u4f4d\u975e\u5e94\u7b54\u8005\uff09\u7684\u6297PD-1\u524d\u540e\u6d3b\u68c0\u6837\u672c\u90fd\u53ef\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u670912\u4e2a\u7c07\u7684CD8+<\/sup> TIL\uff0c\u6700\u4e30\u5bcc\u7684\u7ec8\u672b\u8017\u7aed\uff08TTE\uff09<\/strong><\/span>\u7ec6\u80de\u4e9a\u7fa4\u53ef\u4ee5\u88ab\u7ec6\u5206\u4e3a\u4e24\u4e2a\u4e9a\u7c07\u3002\u4e00\u4e2a\u4e9a\u7c07\u88ab\u9274\u5b9a\u4e3a\u6781\u5ea6\u8017\u7aed<\/span>\uff08TTE-EEX\uff09<\/span><\/strong>\uff0c\u5176\u5dee\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\u4e0e\u8017\u7aed\u548c\u80bf\u7624\u6297\u539f\u7684\u8bc6\u522b\u76f8\u5173\u3002\u7b2c\u4e8c\u4e2a\u4e9a\u7c07\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u7279\u6027<\/span>\uff08TTE-CTX\uff09<\/strong><\/span>\u5e76\u4e14\u8868\u73b0\u51fa\u8f83\u8f7b\u7684\u8017\u7aed\u7a0b\u5ea6\u3002\u4e24\u4e2a\u4e9a\u7c07\u90fd\u9ad8\u5ea6\u8868\u8fbe\u7ec4\u7ec7\u9a7b\u7559\u57fa\u56e0\uff0c\u4f46\u5728\u8f6c\u5f55\u56e0\u5b50\u65b9\u9762\u5b58\u5728\u5dee\u5f02\u3002TTE-CTX<\/strong>\u6700\u9ad8\u8868\u8fbe\u7ec6\u80de\u6bd2\u6027\u5206\u5b50\uff08\u7a7f\u5b54\u7d20\u3001\u5e72\u6270\u7d20\u548c\u9897\u7c92\u9176<\/strong>\uff09\u548cZNF683\u8f6c\u5f55\u56e0\u5b50<\/strong> – \u8fd9\u4e0e\u7ec4\u7ec7\u9a7b\u7559\u8bb0\u5fc6\uff08TRM\uff09<\/strong>\u7a0b\u5e8f\u7684\u7ef4\u6301\u6709\u5173\u3002TTE-CTX\u8fd8\u4e0a\u8c03HLA-II<\/strong>\u57fa\u56e0\uff0c\u8fd9\u4e0e\u6548\u5e94\u6fc0\u6d3b\u7279\u5f81\u4e00\u81f4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u7814\u7a76\u8fd9\u4e9b\u4e9a\u7fa4\u5982\u4f55\u4e0e\u6297\u539f\u8bc6\u522b\u76f8\u5173\uff0c\u7814\u7a76\u4eba\u5458\u5c06TCR\u514b\u9686\u4e0eCD8+<\/sup> TIL\u7684\u8868\u578b\u8054\u7cfb\u8d77\u6765\u3002CD8+<\/sup> TCR\u514b\u9686\u5bb6\u65cf\u5927\u591a\u6570\u805a\u96c6\u5728\u975e\u8017\u7aed\u8bb0\u5fc6\u578b\uff08TNExM\uff09<\/strong><\/span>\u6216\u8017\u7aed\u578b\uff08TEX\uff09<\/strong><\/span>\u7c07\u4e2d\u3002TNExM<\/strong>\u7c07\u5bcc\u542b\u4e0e\u75c5\u6bd2\u6297\u539f\u7279\u5f02\u6027\u76f8\u5173\u7684\u6807\u5fd7\uff0c\u800cTEX<\/strong>\u5177\u6709\u4e4b\u524d\u4e0e\u80bf\u7624\u53cd\u5e94TIL\u76f8\u5173\u7684\u7279\u5f81\u3002\u8fd9\u4e9b\u53ef\u80fd\u7684\u80bf\u7624\u53cd\u5e94\u6027TIL\u7c7b\u4f3c\u4e8e\u7ec8\u672b\u5206\u5316\u7684TIL\uff0c\u5e76\u5305\u62ec\u5c11\u91cf\u5177\u6709\u8017\u7aed\u578b\u7956\u7ec6\u80de\u7279\u5f81\u7684TIL\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u5c06T\u7ec6\u80de\u52a8\u6001\u4e0e\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u8054\uff0c\u7814\u7a76\u4eba\u5458\u6bd4\u8f83\u4e86\u5e94\u7b54\u8005\u548c\u975e\u5e94\u7b54\u8005\u5728\u6cbb\u7597\u524d\u540e\u7684TME\u3002\u5e94\u7b54\u8005<\/strong>\u5728\u6cbb\u7597\u524d\u7684\u6837\u672c\u4e2d\uff0cCD8+<\/sup> TEX TIL<\/strong>\u7684\u9891\u7387\u66f4\u9ad8\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u662fTTE-CTX<\/strong>\u3002\u901a\u8fc7\u6bd4\u8f83\u516d\u540d\u60a3\u8005\u6cbb\u7597\u524d\u540e\u7684\u914d\u5bf9\u6d3b\u68c0\u6837\u672c\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u6cbb\u7597\u5f00\u59cb\u540e\u4e94\u5468\uff0c\u4e09\u540d\u5e94\u7b54\u8005\u7684CD8+<\/sup> TEX<\/strong>\u7ec6\u80de\u6570\u91cf\u51cf\u5c11\uff0cTNExM<\/strong>\u7ec6\u80de\u7fa4\u4f53\u589e\u52a0\uff0c\u800c\u975e\u5e94\u7b54\u8005\u5e76\u672a\u663e\u793a\u660e\u663e\u5dee\u5f02\u3002\u5e94\u7b54\u8005CD8+<\/sup> TEX<\/strong>\u7ec6\u80de\u6570\u91cf\u7684\u5927\u90e8\u5206\u51cf\u5c11\u662f\u7531\u4e8eCD8+<\/sup> TTE-CTX<\/strong>\u7684\u51cf\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6cbb\u7597\u524d\uff0c\u5e94\u7b54\u8005\u7684CD8+<\/sup> TEX TIL<\/strong>\u4e2d\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u6f5c\u80fd\u7684\u6bd4\u4f8b\u66f4\u9ad8\uff0c\u8fd9\u4e0e\u514d\u75ab\u8367\u5149\u6cd5\u68c0\u6d4b\u5230\u7684\u6cbb\u7597\u524d\u6837\u672c\u4e2d\u7ec4\u7ec7\u9a7b\u7559\u8bb0\u5fc6\u6837\uff08TRM-like\uff09 CD103+<\/sup>PD-1+<\/sup>CD8+<\/sup> TIL<\/strong>\u7684\u66f4\u9ad8\u5bc6\u5ea6\u6709\u5173\uff0c\u800c\u8fd9\u79cd\u6548\u5e94\u5728\u53cd\u5e94\u66f4\u597d\u7684\u60a3\u8005\u4e2d\u66f4\u5f3a\u3002\u8fd9\u4e9bTRM-like TIL\u7684\u5bc6\u5ea6\u5728\u6cbb\u7597\u540e\u7565\u6709\u589e\u52a0\uff0c\u4f46\u5728\u5e94\u7b54\u8005\u4e2d\u4ecd\u7136\u6bd4\u5728\u975e\u5e94\u7b54\u8005\u4e2d\u9ad8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u8005\u4f7f\u7528\u72ec\u7acb\u7684\u961f\u5217\u9a8c\u8bc1\u4e86\u6570\u636e\u3002\u4ece\u53c2\u4e0e\u5148\u524d\u5355\u5242\u91cf\u6d3e\u59c6\u5355\u6297\u8bd5\u9a8c\u768426\u540d\u60a3\u8005\u4e2d\u83b7\u5f97\u7684\u7ec4\u7ec7\u6837\u672c\u7684RNA\u6d4b\u5e8f\u5206\u6790\u663e\u793a\uff0c\u5e94\u7b54\u8005\u7684CD8+<\/sup>\u6d78\u6da6\u66f4\u591a\uff0c\u4e14ZNF683<\/strong>\u548cCTX\u57fa\u56e0\uff08\u4e0eTTE-CTX<\/strong>\u76f8\u5173\uff09\u7684\u57fa\u7ebf\u8868\u8fbe\u66f4\u4e30\u5bcc\u3002\u53e6\u4e00\u4efd\u5305\u542b11\u540d\u60a3\u8005\u63a5\u53d7\u4e09\u5242\u7eb3\u6b66\u5355\u6297\u6cbb\u7597\u7684\u80bf\u7624\u6574\u4f53RNA\u6d4b\u5e8f\u6570\u636e\u7684\u5916\u90e8\u6570\u636e\u96c6\u4e5f\u786e\u8ba4\u4e86ZNF683\u548cCTX\u7279\u5f81\u5728\u6cbb\u7597\u524d\u7684\u5e94\u7b54\u8005\u4e2d\u66f4\u4e30\u5bcc\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u5bf9ICB\u7684\u53cd\u5e94\u4f9d\u8d56\u4e8e\u9884\u5b58\u5728\u7684\u9ad8\u6c34\u5e73\u7684\u8017\u7aed\/\u7ec6\u80de\u6bd2\u6027TIL\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u8005\u7136\u540e\u786e\u5b9a\u4e86\u6cbb\u7597\u524d\u540e\u5355\u4e2aTCR\u514b\u9686\u578b\u7684\u52a8\u6001\u3002\u5728\u53cd\u5e94\u826f\u597d\u8005<\/strong>\u4e2d\uff0c\u5927\u591a\u6570\u6cbb\u7597\u524d\u7684CD8+<\/sup> TEX TILs<\/strong>\u662f\u9ad8\u5ea6\u6269\u589e\u7684\u514b\u9686\u578b\uff0c\u5177\u6709TTE-CTX<\/strong>\u8868\u578b\uff0c\u800c\u53cd\u5e94\u4e0d\u826f\u8005<\/strong>\u7684\u6269\u589e\u7684CD8+<\/sup> TEX TCR\u514b\u9686\u578b\u8f83\u5c11\uff0c\u4e3b\u8981\u662fTTE-EEX<\/strong>\u3002\u4e3a\u4e86\u68c0\u67e5\u662f\u5426\u6709\u9884\u5b58\u5728\u7684TCR\u514b\u9686\u578b\u6301\u7eed\u5b58\u5728\uff0c\u6216\u8005\u6709\u65b0\u7684T\u7ec6\u80de\u6d41\u5165\uff0cTCR\u514b\u9686\u578b\u88ab\u5206\u7c7b\u4e3a\u53ea\u5728\u6cbb\u7597\u524d\u7684\u6837\u672c\u4e2d\u51fa\u73b0\uff08\u4e22\u5931\uff09\uff0c\u53ea\u5728\u6cbb\u7597\u540e\u7684\u6837\u672c\u4e2d\u51fa\u73b0\uff08\u65b0\u7684\uff09\uff0c\u6216\u8005\u5728\u6cbb\u7597\u524d\u540e\u7684\u6837\u672c\u4e2d\u90fd\u51fa\u73b0\uff08\u6301\u7eed\u5b58\u5728\uff09\u3002\u6cbb\u7597\u540e\u6709\u8bb8\u591a\u65b0\u7684TCR\u514b\u9686\u578b\uff0c\u4f46\u5927\u591a\u6570\u5e76\u672a\u6269\u5927\uff0c\u53ef\u80fd\u5bf9\u6cbb\u7597\u540e\u7684\u6297\u80bf\u7624\u53cd\u5e94\u5728\u53cd\u5e94\u826f\u597d\u8005\u548c\u53cd\u5e94\u4e0d\u826f\u8005\u7684\u5dee\u5f02\u4e2d\u7684\u8d21\u732e\u5f88\u5c0f\u3002\u8bb8\u591a\u5728\u57fa\u7ebf\u68c0\u6d4b\u5230\u7684\u514b\u9686\u578b\u5728\u6cbb\u7597\u540e\u6301\u7eed\u5b58\u5728\uff08\u5360\u6240\u6709CD8+<\/sup> TIL\u768460-70%\uff09\uff0c\u53cd\u5e94\u826f\u597d\u8005\u7684\u6301\u7eed\u514b\u9686\u578b\u6bd4\u4f8b\u66f4\u5927\uff0c\u4e14\u5728\u6cbb\u7597\u540e\u66f4\u591a\u5730\u6269\u5f20\u3002\u5728\u53cd\u5e94\u826f\u597d\u8005\u4e2d\uff0c\u6301\u7eed\u7684\u5e76\u4e14\u6269\u5f20\u7684CD8+<\/sup> TEX\u514b\u9686\u578b\u5728\u6cbb\u7597\u540e\u6536\u7f29\uff1b\u56e0\u6b64\uff0c\u53cd\u5e94\u826f\u597d\u8005\u5728\u6cbb\u7597\u540e\u4e22\u5931\u7684\u514b\u9686\u578b\u6bd4\u4f8b\u66f4\u9ad8\uff0c\u800c\u53cd\u5e94\u4e0d\u826f\u8005\u7684TEX\u514b\u9686\u6bd4\u4f8b\u6ca1\u6709\u53d8\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728CD4+<\/sup> T\u7ec6\u80de\u7fa4\u4f53\u4e2d\uff0c\u68c0\u6d4b\u5230\u4e86TNExM\u3001TEX\u3001GZMK+<\/sup> T\u548cTregs\u3002TEX\u548cTGZMK\u5bcc\u542b\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u80bf\u7624\u7279\u5f02\u6027TCR\u7684\u7279\u5f81\u3002\u5728\u53cd\u5e94\u826f\u597d\u8005\u4e2d\uff0cCD4+<\/sup>\u7ec6\u80de\u7fa4\u4f53\u4e2d\u7684\u8017\u7aed\u7ec6\u80de\u5bcc\u96c6\u60c5\u51b5\u4e0eCD8+<\/sup>\u7ec6\u80de\u7fa4\u4f53\u7c7b\u4f3c\uff0c\u800c\u53cd\u5e94\u4e0d\u826f\u8005\u7684CD4+<\/sup> TNExM\u9891\u7387\u66f4\u9ad8\u3002Tregs\u7684\u6bd4\u4f8b\u5728\u53cd\u5e94\u826f\u597d\u8005\u548c\u53cd\u5e94\u4e0d\u826f\u8005\u4e2d\u76f8\u4f3c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6240\u6709\u4e22\u5931\u7684\u3001\u65b0\u7684\u548c\u6301\u7eed\u7684TNExM\u548cTEX TCR\u514b\u9686\u578b\u4e2d\uff0c\u5047\u5b9a\u7684\u80bf\u7624\u53cd\u5e94\u6027TEX TCR\u514b\u9686\u578b\u663e\u793a\u51fa\u6700\u591a\u7684\u6cbb\u7597\u8bf1\u5bfc\u5dee\u5f02\u3002\u5728\u53cd\u5e94\u826f\u597d\u8005\u4e2d\uff0c\u6301\u7eed\u6216\u4e22\u5931\u7684TCR\u514b\u9686\u578b\u7684\u7ec6\u80de\u8868\u8fbe\u6700\u9ad8\u6c34\u5e73\u7684\u53cd\u5e94\u76f8\u5173\u8f6c\u5f55\u7269\uff0c\u5982\u7ec6\u80de\u6bd2\u6027\u57fa\u56e0\uff0c\u5e76\u4e14\u8fd9\u4e9bTIL\u4e5f\u5177\u6709\u6700\u9ad8\u7684\u7ec6\u80de\u6bd2\u6027\u8bc4\u5206\u548c\u4e2d\u7b49\u6c34\u5e73\u7684\u8017\u7aed\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u53cd\u5e94\u4e0d\u826f\u8005\u4e2d\u6301\u7eed\u5b58\u5728\u7684TEX\u514b\u9686\u578b\u9ad8\u5ea6\u5bcc\u542b\u4e0e\u53cd\u5e94\u7f3a\u4e4f\u76f8\u5173\u7684\u8f6c\u5f55\u7269\uff08\u8017\u7aed\u57fa\u56e0\uff09\uff0c\u5e76\u4e14\u8fd9\u4e9b\u60a3\u8005\u4e2d\u6269\u5927\u7684\u514b\u9686\u578b\u5177\u6709\u6700\u9ad8\u7684\u8017\u7aed\u6c34\u5e73\u3002\u5728\u5047\u5b9a\u7684\u80bf\u7624\u53cd\u5e94\u6027CD8+<\/sup> TEX\u514b\u9686\u578b\u4e2d\uff0c\u8017\u7aed\u6c34\u5e73\u5728\u53cd\u5e94\u826f\u597d\u8005\u548c\u53cd\u5e94\u4e0d\u826f\u8005\u4e2d\u90fd\u6ca1\u6709\u51cf\u5c11\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e5f\u6ca1\u6709\u83b7\u5f97\u8bb0\u5fc6\u8868\u578b\u3002\u8ffd\u8e2a\u4e0e\u53cd\u5e94\u76f8\u5173\u7684\u514b\u9686\u578b\u663e\u793a\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u6cbb\u7597\u524d\u6837\u672c\u4e2d\u7ea6\u5360CD8+<\/sup> TEX\u768455%\u548c\u6240\u6709CD8+<\/sup> TIL\u768432%\u3002\u9ad8\u5ea6\u6269\u5f20\u7684\u514b\u9686\u578b\u8868\u8fbeZNF683\u548cCTX\u57fa\u56e0\uff0c\u800c\u5728\u53cd\u5e94\u4e0d\u826f\u8005\u4e2d\uff0c\u8fd9\u4e00\u7fa4\u4f53\u53ea\u5360\u6240\u6709CD8+<\/sup> TIL\u7684\u5927\u7ea64%\u3002\u5728\u53cd\u5e94\u826f\u597d\u8005\u4e2d\uff0c\u8868\u8fbeZNF683\u548cCTX\u57fa\u56e0\u7684\u7fa4\u4f53\u5728\u6cbb\u7597\u540e\u6700\u591a\u5730\u964d\u4f4e\uff0c\u8fd9\u662f\u901a\u8fc7\u8fd9\u4e9b\u514b\u9686\u578b\u7684\u6536\u7f29\u5b9e\u73b0\u7684\u3002\u53cd\u5e94\u4e0d\u826f\u8005\u5219\u4e3b\u8981\u662f\u5728\u6781\u5ea6\u8017\u7aed\u72b6\u6001\u7684\u9884\u5b58\u5728TEX TCR\u514b\u9686\u578b\uff0c\u8fd9\u5728\u6cbb\u7597\u540e\u5e76\u672a\u6539\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9b\u6570\u636e\u663e\u793a\uff0c\u5bf9HNSCC\u4e2d\u7684\u6297PD-1\u6cbb\u7597\u7684\u53cd\u5e94\u53ef\u80fd\u662f\u7531\u5728\u6cbb\u7597\u524d\u5b58\u5728\u4e8eHNSCC TME\u4e2d\u7684CD8+<\/sup> TEX TIL\u5f15\u8d77\u7684\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5177\u6709\u5f3a\u70c8\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u9a7b\u7559\u8bb0\u5fc6\u7279\u5f81\u3002\u8fd9\u4e2a\u65b0\u53d1\u73b0\u4e0e\u5176\u4ed6\u75be\u75c5\u7684\u673a\u5236\u7814\u7a76\u4e0d\u540c\uff0c\u540e\u8005\u8bc6\u522b\u51fa\u80bf\u7624\u5185\u90e8\u8017\u7aed\u7a0b\u5ea6\u8f83\u8f7b\u7684\u7ec6\u80de\uff08\u514b\u9686\u590d\u6d3b\uff09\u548c\u65b0\u7684\u514b\u9686\u578b\uff08\u514b\u9686\u66ff\u6362\uff09\u7684\u6269\u5f20\u3002\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u53ef\u4ee5\u5e2e\u52a9\u786e\u5b9a\u54ea\u4e9b\u60a3\u8005\u53ef\u80fd\u6700\u80fd\u4eceICB\u6cbb\u7597\u4e2d\u53d7\u76ca\uff0c\u5e76\u63d0\u4f9b\u4e00\u4e9b\u5173\u4e8e\u4e3a\u4f55\u4e00\u90e8\u5206\u60a3\u8005\u6ca1\u6709\u5e94\u7b54\u7684\u7ebf\u7d22\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f5c\u8005\u9762\u5bf9\u9762<\/strong><\/p>\n<\/section>\n

\n
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\n

\u672c\u672c\u5468\uff0c\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Alex Afeyan\u56de\u7b54\u4e86\u6211\u4eec\u7684\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Alex Afeyan<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u8fd9\u9879\u7814\u7a76\u4e2d\u6700\u4ee4\u4f60\u60ca\u8bb6\u7684\u53d1\u73b0\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n

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\n

\u6700\u4ee4\u6211\u60ca\u8bb6\u7684\u53d1\u73b0\u662f\uff0c\u5728\u6211\u4eec\u5206\u6790\u7684\u60a3\u8005\u4e2d\uff0c\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\u4f3c\u4e4e\u7531\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u7684\u72b6\u6001\u9884\u5148\u51b3\u5b9a\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728\u6211\u4eec\u7814\u7a76\u7684\u65f6\u95f4\u8303\u56f4\u5185\uff0cPD-1\u963b\u65ad\u53cd\u5e94\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\u4f3c\u4e4e\u662f\u6062\u590d\u6cbb\u7597\u524d\u5b58\u5728\u7684\u80bf\u7624\u6d78\u6da6CD8+<\/sup> T\u7ec6\u80de\u514b\u9686\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002\u4ee5\u524d\u7684\u7814\u7a76\u5f3a\u8c03\u4e86\u6297PD-1\u53cd\u5e94\u7684\u4e24\u79cd\u673a\u5236\uff0c\u8981\u4e48\u662f\u62db\u52df\u65b0\u7684\u6297\u80bf\u7624T\u7ec6\u80de\u514b\u9686\u5230\u80bf\u7624\uff08\u514b\u9686\u66ff\u4ee3\uff09\uff0c\u8981\u4e48\u662f\u4f7f\u8017\u7aed\u7684T\u7ec6\u80de\u514b\u9686\u6062\u590d\u5230\u8f83\u5c11\u8017\u7aed\u7684\u7956\u5148\u72b6\u6001\uff08\u514b\u9686\u590d\u6d3b\uff09\u3002\u7136\u800c\uff0c\u5728\u5934\u9888\u764c\u4e2d\uff0c\u6211\u4eec\u770b\u5230\u5e94\u7b54\u8005\u5bcc\u542b\u7ef4\u6301\u7ec4\u7ec7\u9a7b\u7559\u3001\u7ec6\u80de\u6bd2\u6027\u8868\u578b\u7684\u9884\u5b58\u5728\u7684T\u7ec6\u80de\u514b\u9686\u7684\u6269\u589e\uff0c\u5e76\u4e14\u7ecf\u5386\u4e86\u201c\u7ec6\u80de\u6bd2\u590d\u6d3b\u201d\uff0c\u5728\u5e94\u7b54\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u91ca\u653e\u4ed6\u4eec\u7684\u6297\u80bf\u7624\u6f5c\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u524d\u666f\u5982\u4f55\uff1f<\/strong><\/p>\n

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\n

\u901a\u8fc7\u6bd4\u8f83\u5e94\u7b54\u8005\u548c\u975e\u5e94\u7b54\u8005\u7684\u7814\u7a76\uff0c\u6211\u4eec\u786e\u5b9a\u4e86\u4e00\u4e2a\u8868\u8fbe\u7ec6\u80de\u6bd2\u6f5c\u80fd\u548c\u7ec4\u7ec7\u9a7b\u7559\u6807\u8bb0\uff08ZNF683+<\/sup> CTX+<\/sup> TILs\uff09\u7684\u80bf\u7624\u6d78\u6da6CD8+<\/sup> T\u7ec6\u80de\u7fa4\u4f53\uff0c\u8fd9\u4e2a\u7fa4\u4f53\u663e\u8457\u9884\u6d4b\u5e76\u4f3c\u4e4e\u9a71\u52a8\u4e86\u5934\u9888\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u53cd\u5e94\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u6211\u4eec\u5bf9\u8fd9\u4e2a\u7fa4\u4f53\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7279\u5f81\u7684\u5206\u6790\u5728\u672a\u6765\u53ef\u4ee5\u7528\u6765\u901a\u8fc7\u5c06\u60a3\u8005\u6309\u7167\u5bf9\u6297PD-1\u7597\u6cd5\u7684\u53cd\u5e94\u53ef\u80fd\u6027\u8fdb\u884c\u5206\u5c42\u6765\u6307\u5bfc\u6cbb\u7597\u3002\u6b64\u5916\uff0c\u6211\u4eec\u5bf9\u5916\u90e8\u6570\u636e\u96c6\u7684\u5206\u6790\u8868\u660e\uff0c\u7ec6\u80de\u6bd2\u590d\u6d3b\u7684\u673a\u5236\u53ef\u80fd\u4e5f\u5728\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u4e2d\u6d3b\u8dc3\u3002\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u786e\u5b9a\u662f\u4ec0\u4e48\u80bf\u7624\u7279\u6027\u9a71\u52a8\u4e86\u53cd\u5e94\u673a\u5236\uff0c\u4ee5\u53ca\u4e3a\u4ec0\u4e48\u975e\u5e94\u7b54\u8005\u60a3\u8005\u7684\u80bf\u7624\u5fae\u73af\u5883\u65e0\u6cd5\u652f\u6301ZNF683+<\/sup> CTX+<\/sup> TILs\u7684\u6269\u589e\uff0c\u800c\u662f\u66f4\u503e\u5411\u4e8e\u652f\u6301\u4e25\u91cd\u8017\u7aed\u548c\u529f\u80fd\u5931\u8c03\u7684T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u5de5\u4f5c\u4e4b\u5916\uff0c\u4f60\u6700\u8fd1\u5b66\u5230\u7684\u6700\u9177\u7684\u4e8b\u60c5\u662f\u4ec0\u4e48\uff1f<\/strong><\/p>\n

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\u4f5c\u4e3a\u4e00\u540d\u6ce2\u58eb\u987f\u4f53\u80b2\u8ff7\uff0c\u6211\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u91cc\u4ece\u4e00\u4e9b\u5c0f\u5c0f\u7684\u5931\u843d\u4e2d\u5b66\u4e60\u5230\u4e86\u575a\u97e7\u548c\u9006\u88ad\u7684\u529b\u91cf\uff0c\u4ee5\u53ca\u6211\u4eec\u5982\u4f55\u80fd\u591f\u632f\u4f5c\u5e76\u652f\u6301\u6211\u4eec\u5fc3\u7231\u7684\u961f\u4f0d\u3002\u6211\u4e00\u76f4\u966a\u7740\u5404\u79cd\u7403\u961f\u8d62\u5f97\u8d85\u7ea7\u7897\u3001\u4e16\u754c\u7cfb\u5217\u8d5b\u3001NBA\u603b\u51b3\u8d5b\u548c\u65af\u5766\u5229\u676f\u3002\u5c3d\u7ba1\u8fc7\u53bb\u51e0\u5e74\u6211\u4eec\u5728\u5b63\u540e\u8d5b\u4e2d\u7ecf\u5386\u4e86\u8bb8\u591a\u6b21\u5931\u5229\uff0c\u8fd9\u8ba9\u65b0\u82f1\u683c\u5170\u5730\u533a\u4ee5\u5916\u7684\u4eba\u611f\u5230\u6b23\u559c\uff0c\u4f46\u6211\u4eec\u7684\u961f\u4f0d\u603b\u80fd\u91cd\u65b0\u632f\u4f5c\u8d77\u6765\uff0c\u56e2\u7ed3\u4e00\u5fc3\uff0c\u575a\u6301\u6597\u4e89\uff0c\u8fd9\u7ed9\u4e86\u6211\u4eec\u5730\u533a\u7684\u8bb8\u591a\u7c89\u4e1d\u5e0c\u671b\u3002\u8ba9\u6211\u4eec\u4e3a\u51ef\u5c14\u7279\u4eba\u3001\u7231\u56fd\u8005\u3001\u718a\u548c\u7ea2\u889c\u961f\u52a0\u6cb9\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG & Sci Immunol.<\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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