{"id":3175,"date":"2023-10-18T11:16:45","date_gmt":"2023-10-18T03:16:45","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/10\/18\/2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%8c\/"},"modified":"2023-10-18T11:16:45","modified_gmt":"2023-10-18T03:16:45","slug":"2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%8c","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/10\/18\/2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%ba%8c\/","title":{"rendered":"2023\u5e74\u56fd\u9645\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u4e8c"},"content":{"rendered":"
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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1. \u501f\u9274\u81ea\u7136\u514d\u75ab\u4ee5\u521b\u5efa\u5408\u6210\u514d\u75ab<\/strong><\/p>\n

George Coukos – \u6d1b\u6851\u5927\u5b66\u533b\u9662\uff08CHUV\uff09\/\u8054\u5408\u56fd\u9645\u764c\u75c7\u7814\u7a76\u6240\uff08UNIL-Ludwig Institute for Cancer Research\uff09\uff0c\u745e\u58eb\u6d1b\u6851<\/span><\/strong><\/p>\n<\/section>\n

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\u91c7\u7528\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de (TILs) \u7684\u514d\u75ab\u7ec6\u80de\u7597\u6cd5 (ACT) \u662f\u4e00\u79cd\u88ab\u5e7f\u6cdb\u7814\u7a76\u7684\u514d\u75ab\u7597\u6cd5\uff0c\u5bf9\u4e8e\u5b8c\u5168\u5e94\u7b54\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u5e26\u6765\u663e\u8457\u4e14\u6301\u4e45\u7684\u53cd\u5e94\u4ee5\u53ca\u975e\u5e38\u4e50\u89c2\u7684\u9884\u540e\u3002George Coukos \u5728\u745e\u58eb\u6d1b\u6851\u4e3a\u60a3\u6709\u9ed1\u7d20\u7624\u7684\u60a3\u8005\u5efa\u7acb\u4e86\u4e00\u9879 TIL \u7597\u6cd5\u65b9\u6848\uff0c\u5176\u4e2d\u60a3\u8005\u7684 TIL \u901a\u8fc7\u5feb\u901f\u6269\u589e\u7684\u65b9\u6cd5\u5728\u4f53\u5916\u6269\u589e\uff0c\u5e76\u5728\u975e\u9aa8\u9ad3\u6291\u5236\u6027\u5316\u7597\u540e\u8f93\u56de\u60a3\u8005\u4f53\u5185\u3002IL-2 \u7528\u4e8e\u652f\u6301\u8f6c\u79fb\u7684 TIL \u5728\u4f53\u5185\u7684\u6269\u589e\uff0c\u7136\u540e\u6bcf\u4e24\u5468\u8fdb\u884c\u4e00\u6b21\u6297 PD-1 \u7597\u6cd5\uff0c\u6301\u7eed 30 \u5929\u3002\u6709 13 \u4f4d\u9ed1\u7d20\u7624\u60a3\u8005\u53c2\u4e0e\u4e86\u8fd9\u9879\u7814\u7a76\uff0c\u4ed6\u4eec\u5148\u524d\u90fd\u63a5\u53d7\u8fc7\u6297 PD-1 \u7597\u6cd5\uff0c\u5e76\u4e14\u8981\u4e48\u8010\u836f\uff0c\u8981\u4e48\u4ea7\u751f\u6297\u836f\u6027\uff0c\u8981\u4e48\u56e0\u4e3a\u6bd2\u6027\u505c\u6b62\u3002\u8fd913\u540d\u60a3\u8005\u90fd\u63a5\u53d7\u4e86 TIL \u7597\u6cd5\u3002\u5176\u4e2d 6 \u540d\u60a3\u8005\u4ea7\u751f\u4e86\u4e34\u5e8a\u5e94\u7b54\uff0c\u800c\u5176\u4f59 7 \u540d\u60a3\u8005\u6ca1\u6709\u54cd\u5e94\uff0c\u8fd9\u4e0e\u5176\u4ed6\u673a\u6784\u7684\u7ecf\u9a8c\u76f8\u7b26\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6240\u6709\u60a3\u8005\u5728\u6cbb\u7597\u524d\u90fd\u6709\u4e00\u7ec4\u8be6\u7ec6\u5206\u6790\u80bf\u7624\u5fae\u73af\u5883 (TME) \u7684\u5bf9\u7167\u6837\u672c\u3002\u5355\u7ec6\u80de\u6d4b\u5e8f\uff0c\u591a\u91cd\u514d\u75ab\u8367\u5149\u663e\u5fae\u955c (mIF) \u7684\u7ed3\u679c\u8868\u660e\uff0c\u5e94\u7b54\u8005\u7684\u80bf\u7624\u66f4\u591a\u5730\u88ab T \u7ec6\u80de\u6d78\u6da6\uff0c\u5e76\u4e14\u6d78\u6da6\u7684 T \u7ec6\u80de\u8868\u73b0\u51fa\u8017\u7aed\u3001TCR \u4fe1\u53f7\u6fc0\u6d3b\u3001PD-1+<\/sup>\u3001\u548c\u5177\u6709 CD28 \u4fe1\u53f7\u6807\u8bb0\u7684\u7ec6\u80de\u6bd2\u6027\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u8fdb\u4e00\u6b65\u5229\u7528\u8fd9\u4e9b\u76f8\u5173\u7ec6\u80de\uff0c\u5f00\u53d1\u4e86 Neo-TIL \u8fc7\u7a0b\uff0c\u8be5\u8fc7\u7a0b\u5305\u62ec\u8bc6\u522b\u60a3\u8005\u7279\u5f02\u6027\u7684\u65b0\u6297\u539f\u80bd\uff0c\u5e76\u4f7f\u7528\u8fd9\u4e9b\u80bd\u51b2\u51fb\u81ea\u4f53 APC\uff0c\u4ee5\u5728\u975e\u7279\u5f02\u6027 T \u7ec6\u80de\u6269\u589e\u4e4b\u524d\u7279\u5f02\u6027\u6269\u589e\u65b0\u6297\u539f\u7279\u5f02\u6027 T \u7ec6\u80de 10 \u5929\u3002\u4e00\u4e9b\u80bf\u7624\u76f8\u5173\u6297\u539f\uff0c\u5982 MAGEA10\u3001WT-1 \u548c HER2\uff0c\u4e5f\u88ab\u4f7f\u7528\u3002\u8fd9\u4e2a\u8fc7\u7a0b\u5728\u591a\u79cd\u80bd\u548c\u591a\u79cd\u80bf\u7624\u7ec4\u7ec7\u7c7b\u578b\u4e4b\u95f4\u975e\u5e38\u6709\u6548\uff0c\u5bfc\u81f4\u80bf\u7624\u7279\u5f02\u6027 CD8+<\/sup> T \u7ec6\u80de\u7684\u9891\u7387\u589e\u52a0 10-100 \u500d\uff0c\u6709\u65f6\u6bd4\u4f8b\u5360\u5230 75%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6709\u4e09\u4e2a\u60a3\u8005\u5728\u63a5\u53d7 50-70 \u4ebf\u6269\u589e\u7684 Neo-TILs\uff08\u5176\u4e2d 17-50% \u4e3a\u80bf\u7624\u7279\u5f02\u6027\uff09\u6cbb\u7597\u540e\u88ab\u63cf\u8ff0\u3002\u5176\u4e2d\u4e00\u4f4d\u60a3\u8005\u8fbe\u5230\u4e86\u5b8c\u5168\u5e94\u7b54\u3002\u7b2c\u4e8c\u4f4d\u60a3\u8005\u51fa\u73b0\u4e86\u5feb\u901f\u7684\u90e8\u5206\u53cd\u5e94 (PR)\uff0c\u968f\u540e\u75be\u75c5\u8fdb\u5c55\uff0c\u8868\u73b0\u4e3a\u514d\u75ab\u7f16\u8f91\u8868\u578b\uff08HLA \u8868\u8fbe\u7684\u4e27\u5931\uff09\u3002\u7b2c\u4e09\u4f4d\u60a3\u8005\u7684\u80bf\u7624\u5728\u63a5\u53d7 TIL \u7597\u6cd5\u540e\u66fe\u7ecf\u51fa\u73b0\u80bf\u7624\u6d88\u9000\uff0c\u7ecf\u5386\u4e86\u4e00\u4e2a\u6807\u5fd7\u7740\u5927\u91cf\u65b0\u7684 T \u7ec6\u80de\u6d78\u6da6\u7684 PR\uff0c\u4f46\u80bf\u7624\u6700\u7ec8\u9003\u8131\u4e86\u514d\u75ab\u7f16\u8f91\u7684\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9\u539f\u59cb\u80bf\u7624\u4e2d\u7684 TILs \u7684\u5206\u6790\u663e\u793a\uff0c\u5e94\u7b54\u80bf\u7624\u4e2d\u7684\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u4e4b\u95f4\u6709\u5e7f\u6cdb\u800c\u201c\u5608\u6742\u201d\u7684\u4ea4\u53c9\u5bf9\u8bdd\uff0c\u800c\u975e\u5e94\u7b54\u80bf\u7624\u5219\u663e\u793a\u51fa\u7f3a\u4e4f\u4ea4\u4e92\u7684\u6a21\u5f0f\u3002\u591a\u91cd\u514d\u75ab\u8367\u5149\u663e\u5fae\u955c\u7528\u4e8e\u7814\u7a76\u7ec6\u80de\u201c\u90bb\u5c45\u201d\uff0c\u5e76\u63ed\u793a\u4e86\u5728\u5e94\u7b54\u60a3\u8005\uff08\u5305\u62ec\u80bf\u7624\u548c\u5468\u56f4\u7684\u57fa\u8d28\u7ec4\u7ec7\uff09\u4e2d\uff0c\u5bc6\u5207\u4ea4\u4e92\u7684 CD8+<\/sup>PD1+<\/sup> T \u7ec6\u80de\u548c CD11c+<\/sup> DCs\u7684\u5f3a\u70c8\u5b58\u5728\uff0c\u8fd9\u6697\u793a\u8fd9\u4e9b\u662f\u751f\u6210\u6709\u6548 TIL \u4ea7\u54c1\u7684\u6838\u5fc3\u56e0\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u6839\u636e\u901a\u8fc7 mIF \u68c0\u6d4b\u5230\u514d\u75ab\u7a81\u89e6\u7684\u5b58\u5728\uff0cCYTOF \u5206\u6790\u663e\u793a\uff0c\u8868\u8fbe CD28 \u7684 TILs \u5177\u6709\u66f4\u5f3a\u7684\u6548\u5e94\u548c\u6548\u5e94\u524d\u4f53\u7279\u5f81\uff0c\u5e76\u4e14\u5728 IL-2 \u4fe1\u53f7\u7684\u6807\u5fd7\u4e2d\u7279\u522b\u4e30\u5bcc\u3002\u8fd9\u4e00\u89c2\u5bdf\u4fc3\u4f7f\u4eba\u4eec\u4ea7\u751f\u4e86\u57fa\u56e0\u5de5\u7a0b\u7684 OT-1 T \u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u8868\u8fbe IL-2 \u53d8\u4f53\uff08\u7279\u5f02\u6027\u7ed3\u5408 IL-2\u4f4e\u4eb2\u548c\u529b\u53d7\u4f53\u03b2\u03b3\uff09\u3001\u8b66\u62a5\u7d20 IL-33 \u548c PD-1 \u8bf1\u9975\uff08\u6700\u7ec8\u88ab\u8bc1\u660e\u4e0e\u6d3b\u52a8\u65e0\u5173\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u521a\u521a\u53d1\u5e03\u7684\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b T \u7ec6\u80de\u5206\u5316\u4e3a\u4e00\u79cd\u65b0\u7684\u201c\u5408\u6210\u6548\u5e94\u201d\u72b6\u6001\uff0c\u8fd9\u79cd\u72b6\u6001\u5177\u6709\u6297\u539f\u66b4\u9732\u7279\u5f81\uff08\u4f46\u5e76\u672a\u8017\u7aed\uff09\uff0c\u9ad8\u5ea6\u7ec6\u80de\u6bd2\u6027\uff08\u7279\u522b\u662f\u901a\u8fc7 Gmzc \u7684\u8868\u8fbe\u6807\u8bb0\uff09\u5e76\u663e\u793a\u51fa\u4f18\u8d8a\u7684\u4ee3\u8c22\u9002\u5e94\u6027\u3002\u5728\u51b7\u80bf\u7624\u4e2d\uff0c\u8fd9\u4e9b\u5de5\u7a0b\u5316\u7684 T \u7ec6\u80de\u88ab\u8bc1\u660e\u975e\u5e38\u6709\u6548\uff0c\u5e76\u4e14\u53ef\u4ee5\u5728\u8f93\u6ce8\u540e\u7684 12 \u5929\u5185\u4ece TME \u4e2d\u6062\u590d\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5728\u6ca1\u6709\u6dcb\u5df4\u7ec6\u80de\u6e05\u9664\u6216\u652f\u6301\u6027 IL-2 \u7684\u60c5\u51b5\u4e0b\u4e5f\u80fd\u6709\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2. <\/strong>\u80bf\u7624\u5fae\u73af\u5883\u9a71\u52a8\u7684GD2 CAR T\u7ec6\u80de\u9884\u9632\u4e86\u975e\u80bf\u7624\u9776\u5411\u7684\u7ec6\u80de\u6bd2\u6027<\/strong><\/p>\n<\/section>\n

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Kristen Vogt-\u7ebd\u7ea6\u7f8e\u56fd\u7eaa\u5ff5\u65af\u9686\u00b7\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3<\/strong><\/p>\n<\/section>\n

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\u5bfb\u627e\u9002\u7528\u4e8e CAR T \u7ec6\u80de\u7597\u6cd5\u7684\u9ad8\u5ea6\u7279\u5f02\u6027\u9776\u6807\u662f\u4e00\u9879\u6311\u6218\uff0c\u9776\u70b9\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u6f5c\u5728\u9ad8\u8868\u8fbe\u53ef\u80fd\u5bfc\u81f4\u660e\u663e\u7684\u9776\u5411\u4f46\u975e\u80bf\u7624\u7684\u7ec6\u80de\u6bd2\u6027\u3002GD2 \u5c31\u662f\u4e00\u4e2a\u5178\u578b\u4f8b\u5b50\uff0c\u5b83\u5728\u5404\u79cd\u8111\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u975e\u5e38\u9ad8\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e2a\u95ee\u9898\uff0c\u4eba\u4eec\u4e3a CAR T \u7ec6\u80de\u5f00\u53d1\u4e86\u5e03\u5c14 AND \u903b\u8f91\u73af\u8def\uff0c\u9700\u8981\u901a\u8fc7\u4e00\u4e2a\u80bf\u7624\u7279\u5f02\u6027\u9776\u6807\u7684\u6fc0\u6d3b\u624d\u80fd\u8bf1\u5bfc\u8868\u8fbe\u9488\u5bf9\u7b2c\u4e8c\u4e2a\u9776\u6807\u7684 CAR\uff0c\u4ece\u800c\u542f\u52a8\u7ec6\u80de\u6bd2\u6027\u3002synNotch \uff0c\u8fd9\u79cd\u91ca\u653e\u8f6c\u5f55\u56e0\u5b50\u7684\u73af\u8def\u5c31\u662f\u5176\u4e2d\u4e4b\u4e00\u3002Kristen Vogt \u63d0\u51fa\u4e86\u4e00\u4e2a\u5047\u8bbe\uff0c\u8ba4\u4e3a\u53ef\u4ee5\u901a\u8fc7\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u627e\u5230\u7684\u6b63\u5e38\u7ec6\u80de\u4e0a\u7684 TME \u7279\u5f02\u6027\u6807\u8bb0\u6765\u6fc0\u6d3b\u8be5\u73af\u8def\uff0c\u4ece\u800c\u6fc0\u6d3b\u9488\u5bf9\u80bf\u7624\u7ec6\u80de\u7279\u5f02\u6027\u9776\u6807\u7684 CAR \u8868\u8fbe\uff0c\u5c06\u7ec6\u80de\u6bd2\u6027\u9650\u5236\u5728\u80bf\u7624\u533a\u57df\u5185\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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P-\u9009\u62e9\u7d20\u5728\u5b9e\u4f53\u80bf\u7624\u7684\u8840\u7ba1\u4e2d\u548c\u5bf9\u8f90\u5c04\u7684\u53cd\u5e94\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u56e0\u6b64\u88ab\u63d2\u5165\u5230\u4ee5 CD19 \u4e3a\u80bf\u7624\u7279\u5f02\u6027\u9776\u6807\u7684 synNotch CAR T \u7ec6\u80de\u4e2d\uff0c\u4f5c\u4e3a\u9a71\u52a8\u9776\u6807\u3002\u91cd\u7ec4\u7684 P-\u9009\u62e9\u7d20\u3001\u5728\u9776\u7ec6\u80de\u4e0a\u987a\u5f0f\u8868\u8fbe\u7684 P-\u9009\u62e9\u7d20\u6216\u8005\u5728\u975e\u9776\u7ec6\u80de\u4e0a\u53cd\u5f0f\u8868\u8fbe\u7684 P-\u9009\u62e9\u7d20\u90fd\u80fd\u6fc0\u6d3b\u73af\u8def\uff0c\u5bfc\u81f4\u9488\u5bf9 CD19 \u7684\u7ec6\u80de\u6740\u4f24\u3002\u7136\u540e\uff0c\u8fd9\u79cd\u65b9\u6cd5\u88ab\u5e94\u7528\u5230 GD2 CAR \u7cfb\u7edf\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cGD2 \u662f\u8bb8\u591a\u5b9e\u4f53\u80bf\u7624\u7684\u7406\u60f3\u9776\u6807\uff0c\u4f46\u662f\u5df2\u77e5\u9ad8\u4eb2\u548c\u529b\u7684 GD2 CAR \u7531\u4e8e\u5728\u6b63\u5e38\u8111\u7ec4\u7ec7\u4e2d\u7684\u9ad8\u8868\u8fbe\u800c\u663e\u793a\u51fa\u81f4\u547d\u7684\u795e\u7ecf\u6bd2\u6027\u3002P-\u9009\u62e9\u7d20\u95e8\u63a7\u7684 GD2 CAR T \u7ec6\u80de\u663e\u8457\u51cf\u5c11\u4e86\u5bf9\u8111\u7ec4\u7ec7\u7684\u6d78\u6da6\u548c\u76f8\u5173\u7684\u795e\u7ecf\u6bd2\u6027\u3002\u5728\u4e00\u4e2a P-\u9009\u62e9\u7d20+<\/sup>GD2+<\/sup> K562 \u76ae\u4e0b\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u9759\u8109\u8f93\u6ce8\u7684 P-\u9009\u62e9\u7d20\u95e8\u63a7 \u7684CAR T \u7ec6\u80de\u80fd\u591f\u63a7\u5236\u80bf\u7624\u7684\u751f\u957f\uff0c\u800c\u4e14\u6ca1\u6709\u663e\u793a\u51fa\u5bf9\u8111\u90e8\u7684\u6d78\u6da6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3. Tebentafusp – \u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u8461\u8404\u819c\u9ed1\u8272\u7d20\u7624\u7684gp100\u5b9a\u5411TCR-CD3\u53cc\u7279\u5f02\u6027\u836f\u7269<\/strong><\/p>\n<\/section>\n

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Koustubh Ranade-\u7f8e\u56fd\u6d1b\u514b\u7ef4\u5c14Immunocore\u516c\u53f8<\/strong>
<\/p>\n<\/section>\n

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Tebentafusp\uff08Kimmtrak\u00ae\uff09\u662f\u4e00\u79cd\u5177\u6709\u521b\u65b0\u6027\u7684\u3001\u5373\u7528\u5373\u53d6\u7684\u53cc\u7279\u5f02\u6027\u86cb\u767d\uff0c\u7531\u6297CD3\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff08scFv\uff09\u548c\u5bf9gp100\uff08YLEPGPVTA\uff09-HLA*A02:01\u590d\u5408\u4f53\u6709\u6eb6\u89e3\u6027\u9ad8\u4eb2\u548c\u529b\u7684T\u7ec6\u80de\u53d7\u4f53\u7ec4\u6210\u3002\u6700\u8fd1\uff0c\u8fd9\u79cd\u836f\u7269\u5df2\u572830\u591a\u4e2a\u56fd\u5bb6\u83b7\u5f97\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u773c\u8109\u7edc\u819c\u9ed1\u8272\u7d20\u7624\uff08mUM\uff09\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u76ae\u80a4\u9ed1\u8272\u7d20\u7624\u76f8\u6bd4\uff0c\u773c\u8109\u7edc\u819c\u9ed1\u8272\u7d20\u7624\u7684\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u8f83\u4f4e\uff0c\u5e76\u4e14\u5bf9\u68c0\u67e5\u70b9\u963b\u65ad\u53cd\u5e94\u8f83\u4f4e\u3002\u6839\u636eKoustubh Ranade\u7684\u8bf4\u6cd5\uff0c\u591a\u8fbe50%\u7684\u773c\u8109\u7edc\u819c\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4f1a\u53d1\u5c55\u4e3a\u8f6c\u79fb\u6027\u75be\u75c5\uff0c\u809d\u810f\u662f\u8f6c\u79fb\u7684\u4e3b\u8981\u90e8\u4f4d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e00\u9879\u9488\u5bf9\u5148\u524d\u672a\u63a5\u53d7\u6cbb\u7597\u7684HLA*A02:01\u9633\u6027mUM\u60a3\u8005\u7684\u968f\u673a\u5206\u914d\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4f7f\u7528Tebentafusp\u6cbb\u7597\u7684\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a21.7\u4e2a\u6708\uff0c\u800c\u7814\u7a76\u8005\u9009\u62e9\u7684\u6cbb\u7597\u65b9\u6cd5\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a16.0\u4e2a\u6708\uff0882%\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u5355\u836fpembrolizumab\u6cbb\u7597\uff0c13%\u7684\u60a3\u8005\u63a5\u53d7\u4e86ipilimumab\u6cbb\u7597\uff0c6%\u7684\u60a3\u8005\u63a5\u53d7\u4e86dacarbazine\u6cbb\u7597\uff09\u3002\u751f\u5b58\u66f2\u7ebf\u5728\u5f00\u59cb\u6cbb\u7597\u540e\u76841\u4e2a\u6708\u5185\u5c31\u5f00\u59cb\u5206\u79bb\uff0cRanade\u6307\u51fa\uff0c\u5373\u5c06\u53d1\u5e03\u7684\u6570\u636e\u4e2d\uff0c\u4f7f\u7528Tebentafusp\u6cbb\u7597\u7684\u60a3\u8005\u7684\u751f\u5b58\u66f2\u7ebf\u6700\u7ec8\u5448\u73b0\u957f\u5c3e\u8d8b\u52bf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u826f\u53cd\u5e94\uff08ARs\uff09\u53ef\u4ee5\u9884\u6d4b\uff0c\u53ef\u7ba1\u7406\uff0c\u5e76\u4e14\u4e0e\u4f5c\u7528\u65b9\u5f0f\u4e00\u81f4\uff08\u4f8b\u5982\uff0c\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u75c7\u548c\u76ae\u75b9\uff09\u3002\u5927\u591a\u6570ARs\u5728\u524d3\u5468\u5185\u51fa\u73b0\u3002\u5728\u63a5\u53d7\u4e86\u4e09\u5242Tebentafusp\u6cbb\u7597\u540e\u7684\u7b2c16\u5929\u53d6\u5f97\u7684\u80bf\u7624\u6d3b\u68c0\u4e2d\uff0c\u80bf\u7624\u5fae\u73af\u5883\u88abT\u7ec6\u80de\u5927\u91cf\u6d78\u6da6\uff0c1\u578b\u548c2\u578b\u5e72\u6270\u7d20\u901a\u8def\u9ad8\u5ea6\u8bf1\u5bfc\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Ranade\u8fd8\u4ecb\u7ecd\u4e86\u53e6\u4e00\u79cd\u76ee\u524d\u6b63\u5728\u7814\u53d1\u4e2d\u7684\u53cc\u7279\u5f02\u6027TCR-TCE\uff0c\u8be5\u836f\u7269\u9488\u5bf9\u7684\u662f\u764c\u75c7\u777e\u4e38\u6297\u539fPRAME\uff0c\u8be5\u6297\u539f\u4e0eHLA*A02:01\u590d\u5408\u4f53\u4e00\u8d77\u5728\u5404\u79cd\u5b9e\u4f53\u7624\u4e2d\u8868\u8fbe\u3002\u5728\u4e00\u98791\u671f\u5242\u91cf\u9012\u589e\u7814\u7a76\u4e2d\uff0c\u8fd9\u79cd\u53cc\u7279\u5f02\u6027TCR-TCE\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\u8868\u73b0\u51fa\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u6d3b\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4. \u63a2\u7d22T\u7ec6\u80de\u53d7\u4f53\u4ee5\u83b7\u53d6\u65b0\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u9776\u70b9<\/strong><\/p>\n

Johanna Olweus – \u5965\u65af\u9646\u5927\u5b66\u533b\u9662\uff0c\u632a\u5a01\u5965\u65af\u9646<\/span><\/strong><\/p>\n<\/section>\n

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Johanna Olweus\u4ee3\u66ffMarcela Maus\u8fdb\u884c\u4e86\u62a5\u544a\uff0c\u5176\u4e13\u6ce8\u4e8eTCR\uff08T\u7ec6\u80de\u53d7\u4f53\uff09\u4e3a\u57fa\u7840\u7684T\u7ec6\u80de\u7597\u6cd5\u7684\u4f18\u52bf\u548c\u5206\u7c7b\u3002\u8fd9\u79cd\u7597\u6cd5\u901a\u8fc7\u8bc6\u522b\u6240\u6709\u7ec6\u80de\u7ec4\u5206\u4e2dMHC\u5448\u9012\u7684\u80bd\u6bb5\uff0c\u6bd4CAR T\u7ec6\u80de\u5177\u6709\u66f4\u5e7f\u6cdb\u7684\u6f5c\u5728\u9776\u6807\u96c6\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5927\u591a\u6570\u4f7f\u7528TCR\u5de5\u7a0b\u5316T\u7ec6\u80de\u7684\u8bd5\u9a8c\u90fd\u9488\u5bf9TAAs\uff08\u80bf\u7624\u76f8\u5173\u6297\u539f\uff0c\u5305\u62ec\u764c\u75c7\u777e\u4e38\u548c\u764c\u80ce\u6297\u539f\uff09\uff0c\u8fd9\u4e9b\u6297\u539f\u5728\u591a\u4e2a\u60a3\u8005\u4e2d\u5171\u4eab\uff0c\u4f46\u901a\u5e38\u663e\u793a\u51fa\u5f02\u8d28\u6027\u548c\u4f4e\u8868\u8fbe\u3002\u5c3d\u7ba1\u9488\u5bf9TAAs\u7684\u4e34\u5e8a\u6210\u529f\u6709\u9650\uff0c\u4f46\u6700\u8fd1\u9488\u5bf9MAGE-A4\u6216WT1\u7684\u8bd5\u9a8c\u5df2\u663e\u793a\u51fa\u4e34\u5e8a\u5f71\u54cd\u7684\u8ff9\u8c61\u3002\u4e5f\u5df2\u7ecf\u9488\u5bf9\u7531\u5355\u6838\u82f7\u9178\u53d8\u5f02\u4ea7\u751f\u7684\u4e2a\u6027\u5316\u65b0\u6297\u539f\u8fdb\u884c\u4e86\u9776\u5411\u3002\u867d\u7136\u65b0\u6297\u539f\u662f\u9ad8\u5ea6\u80bf\u7624\u7279\u5f02\u6027\u7684\uff0c\u5e76\u6709\u53ef\u80fd\u9ad8\u5ea6\u514d\u75ab\u539f\u6027\uff0c\u4f46\u901a\u5e38\u53ea\u6709\u5f88\u4f4e\u6bd4\u4f8b\u7684\u65b0\u6297\u539f\u662f\u514d\u75ab\u539f\u6027\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6bcf\u4f4d\u60a3\u8005\u4ece\u81ea\u4f53T\u7ec6\u80de\u4e2d\u5206\u79bb\u51fa\u591a\u8fbe3\u4e2a\u65b0\u6297\u539f\u7279\u5f02\u6027TCR\uff0c\u89c2\u5bdf\u5230\u7684\u4e34\u5e8a\u6548\u679c\u6781\u5176\u6709\u9650\uff0c16\u540d\u60a3\u8005\u4e2d\u67095\u4eba\u7684\u75be\u75c5\u7a33\u5b9a\u662f\u6700\u597d\u7684\u53cd\u5e94\u3002\u8fd9\u53ef\u80fd\u53d7\u5230\u8fd9\u4e9bTCR\u4f4e\u4eb2\u548c\u529b\u7684\u5f71\u54cd\u3002\u75c5\u6bd2\u6027\u80bf\u7624\u6297\u539f\u5728\u75c5\u6bd2\u9a71\u52a8\u7684\u764c\u75c7\u4e2d\u662f\u4e00\u4e2a\u9ad8\u5ea6\u4e14\u5747\u5300\u8868\u8fbe\u7684\u9776\u6807\uff0c\u5de5\u7a0b\u5316\u7684T\u7ec6\u80de\u91c7\u7528\u9ad8\u4eb2\u548c\u529b\u7684TCR\u9488\u5bf9HPV-E7\u8868\u4f4d\uff0c12\u540d\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6709\u4e00\u534a\u8868\u73b0\u51fa\u90e8\u5206\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u4e2a\u65b0\u7684\u9776\u6807\u7c7b\u522b\u662f\u7279\u5f02\u6027\u7ec6\u80de\u9776\u6807\uff0c\u5229\u7528\u5176\u72ec\u7279\u7684\u751f\u7269\u5b66\u7279\u5f81\u3002\u4f8b\u5982\uff0cOlweus\u63cf\u8ff0\u4e86\u5979\u9488\u5bf9\u672b\u7aef\u8131\u6c27\u6838\u82f7\u9178\u8f6c\u79fb\u9176\uff08TdT\uff09\u7684\u5de5\u4f5c\uff0c\u8fd9\u662f\u4e00\u4e2a\u5bf9T\u7ec6\u80de\u548cB\u7ec6\u80de\u65e9\u671f\u5206\u5316\u81f3\u5173\u91cd\u8981\u7684\u9176\uff0c\u4f46\u5728\u6210\u719f\u7684\u5faa\u73af\u7ec6\u80de\u4e2d\u4e0d\u8868\u8fbe\u3002\u8fd9\u79cd\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\u7684\u77ed\u6682\u8868\u8fbe\uff0c\u4f46\u5728\u5404\u79cd\u9020\u8840\u6076\u6027\u80bf\u7624\u4e2d\u7684\u6301\u7eed\u8fc7\u8868\u8fbe\u7684\u9776\u6807\u4e3a\u5de5\u7a0b\u5316\u7684TCR-T\u7ec6\u80de\u7597\u6cd5\u6253\u5f00\u4e86\u4e00\u6247\u7a97\u3002\u4f7f\u7528\u9488\u5bf9TdT\u7684\u9ad8\u4eb2\u548c\u529bTCR\uff0cOlweus\u5c0f\u7ec4\u7684\u7ed3\u679c\u663e\u793a\u51fa\u9ad8\u5ea6\u7684\u80bf\u7624\u7279\u5f02\u6027\uff0c\u4fdd\u62a4\u4e86\u6b63\u5e38\u7684T\u548cB\u7ec6\u80de\uff0c\u4ee5\u53ca\u4f53\u5916\u548c\u4eba\u6e90\u5316\u5c0f\u9f20\u4e2d\u7684\u80f8\u817a\u53d1\u751f\u548c\u9020\u8840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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