{"id":3179,"date":"2023-10-29T17:47:28","date_gmt":"2023-10-29T09:47:28","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/10\/29\/2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%89%ef%bc%9a%e9%9d%b6%e5%90%91%e8%82%bf%e7%98%a4\/"},"modified":"2023-10-29T17:47:28","modified_gmt":"2023-10-29T09:47:28","slug":"2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%89%ef%bc%9a%e9%9d%b6%e5%90%91%e8%82%bf%e7%98%a4","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/10\/29\/2023%e5%b9%b4%e5%9b%bd%e9%99%85%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e5%8d%8f%e4%bc%9a%e5%b9%b4%e4%bc%9a-%e4%b8%bb%e9%a2%98%e4%b8%89%ef%bc%9a%e9%9d%b6%e5%90%91%e8%82%bf%e7%98%a4\/","title":{"rendered":"2023\u5e74\u56fd\u9645\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u534f\u4f1a\u5e74\u4f1a-\u4e3b\u9898\u4e09\uff1a\u9776\u5411\u80bf\u7624\u6297\u539f"},"content":{"rendered":"
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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1. <\/strong>\u8868\u89c2\u9057\u4f20\u76f8\u5173\u80bf\u7624\u6297\u539f<\/strong><\/p>\n

Sebastian Amigorena – \u5df4\u9ece\u6cd5\u56fd\u76ae\u5c48\u91cc\u7814\u7a76\u6240<\/span><\/strong><\/p>\n<\/section>\n

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\u4e3a\u4e86\u4e30\u5bcc\u6709\u6f5c\u529b\u5bf9\u6297\u80bf\u7624\u7684\u6297\u539f\u5e93\uff0cSebastian Amigorena\u53ca\u5176\u7814\u7a76\u56e2\u961f\u5bf9\u201c\u6697\u57fa\u56e0\u7ec4\u201d\uff08\u975e\u5e38\u89c4\u8f6c\u5f55\u7684\u57fa\u56e0\u7ec4\u7247\u6bb5\uff09\u8fdb\u884c\u4e86\u6df1\u5165\u7814\u7a76\u3002\u6697\u57fa\u56e0\u7ec4\u867d\u7136\u5728\u6b63\u5e38\u60c5\u51b5\u4e0b\u4e0d\u88ab\u8f6c\u5f55\uff0c\u4f46\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\uff0c\u7531\u4e8e\u8c03\u63a7\u673a\u5236\u5931\u5e38\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4f1a\u5f02\u5e38\u5730\u88ab\u8868\u8fbe\u51fa\u6765\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Amigorena\u7684\u7814\u7a76\u7279\u522b\u5173\u6ce8\u7684\u662f\u80bf\u7624\u9a71\u52a8\u7684\u8868\u89c2\u9057\u4f20\u5b66\u5931\u8c03\uff0c\u8fd9\u79cd\u5931\u8c03\u5bfc\u81f4\u4e86\u539f\u672c\u88ab\u6291\u5236\u7684\u8f6c\u5ea7\u5143\u4ef6\uff08TEs\uff09\u7684\u6fc0\u6d3b\uff0c\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u4e2d\u526a\u63a5\u673a\u5236\u7684\u5e7f\u6cdb\u6539\u53d8\uff0c\u4ece\u800c\u4ea7\u751f\u65b0\u7684\u6297\u539f\u3002\u8fd9\u4e9b\u8f6c\u5ea7\u5143\u4ef6\u5e7f\u6cdb\u5206\u5e03\u5728\u57fa\u56e0\u7ec4\u4e2d\u7684\u5178\u578b\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u9644\u8fd1\u548c\u5185\u90e8\u3002TEs\u7684\u89e3\u538b\u548c\u65b0\u7684\u526a\u63a5\u4e8b\u4ef6\u53ef\u80fd\u4ea7\u751f\u5f02\u5e38\u526a\u63a5\u7684\u878d\u5408\u4ea7\u7269\uff08\u88ab\u79f0\u4e3a\u201cJETs\u201d\uff1bJunctions of Exons with Transposable elements\uff09\uff0c\u8fd9\u4e9b\u878d\u5408\u4ea7\u7269\u5305\u542b\u65b0\u7684\u878d\u5408\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728Amigorena\u5148\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u4ed6\u63cf\u8ff0\u4e86\u4e00\u4e2a\u751f\u7269\u4fe1\u606f\u5b66\u6d41\u7a0b\uff0c\u8be5\u6d41\u7a0b\u7528\u4e8e\u5728\u5c0f\u9f20\u80bf\u7624\u7ec6\u80de\u7cfb\u4e2d\u641c\u7d22\u8fd9\u79cd\u65b0\u7684\u8f6c\u5f55\u672c\uff0c\u5e76\u6210\u529f\u9884\u6d4b\u51fa\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u80bf\u7624\u548c\u7ec4\u7ec7\u7279\u5f02\u6027\u7684\u5019\u9009\u6297\u539f\u3002\u901a\u8fc7\u57fa\u4e8e\u8d28\u8c31\u7684\u514d\u75ab\u80bd\u7ec4\u5b66\uff0c\u4ed6\u4eec\u68c0\u6d4b\u51fa\u4e86\u4e0e\u9884\u6d4b\u6297\u539f\u76f8\u5339\u914d\u7684\u80bd\u6bb5\uff0c\u5176\u4e2d\u4e00\u4e9b\u80bd\u6bb5\u5728\u80bf\u7624\u643a\u5e26\u7684\u52a8\u7269\u4e2d\u88ab\u53d1\u73b0\uff0c\u5e76\u4e14\u8bb8\u591a\u6297\u539f\u5728\u63a5\u79cd\u9884\u9632\u6027\u75ab\u82d7\u540e\u80fd\u591f\u63a7\u5236\u80bf\u7624\u7684\u751f\u957f\u3002\u901a\u8fc7\u6572\u9664\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u56e0\u5b50Setbp1\uff0c\u4ed6\u4eec\u786e\u8ba4\u4e86JETs\u7684\u8868\u89c2\u9057\u4f20\u5b66\u8d77\u6e90\uff0c\u5e76\u5728B16-OVA\u6a21\u578b\u4e2d\u5ef6\u7f13\u4e86\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6297PD-L1\u7597\u6cd5\u663e\u8457\u63d0\u9ad8\u4e86\u8fd9\u79cd\u6297\u80bf\u7624\u6548\u679c\uff0c\u5e76\u8bf1\u5bfc\u4e86\u9488\u5bf9JETs\u7684\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u3002\u5728\u4ed6\u4eec\u6700\u8fd1\u7684\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u5e94\u7528\u4e86\u7c7b\u4f3c\u7684\u6d41\u7a0b\u4e8e\u4eba\u7c7b\u80bf\u7624\u6837\u672c\uff0c\u5e76\u786e\u5b9a\u4e86\u5177\u6709\u7ec4\u7ec7\u548c\u80bf\u7624\u7279\u5f02\u6027\u7684JETs\u8868\u8fbe\u3002\u5728\u5206\u6790\u4e86600\u4e2a\u80ba\u764c\u6837\u672c\u540e\uff0c\u4ed6\u4eec\u786e\u5b9a\u4e86\u4e00\u4e9b\u666e\u904d\u5b58\u5728\u3001\u80bf\u7624\u7279\u5f02\u6027\u548c\u80bf\u7624\u76f8\u5173\u7684JETs\uff0c\u8fd9\u4e9bJETs\u5728\u80bf\u7624\u90bb\u8fd1\u6837\u672c\u6216\u6b63\u5e38\u7ec4\u7ec7GTEX\u6570\u636e\u5e93\u4e2d\u7684\u8868\u8fbe\u8f83\u4f4e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ed6\u4eec\u5bf917\u4e2a\u65b0\u9c9c\u80ba\u764c\u6807\u672c\u8fdb\u884c\u4e86\u6df1\u5165\u7684\u8d28\u8c31\u514d\u75ab\u80bd\u7ec4\u5b66\u5206\u6790\uff0c\u53d1\u73b0\u4e86\u591a\u4e2aHLA-I\u7c7b\u5206\u5b50\u5448\u9012\u7684\u80bd\u6bb5\u3002\u5bf9\u5e94\u7684\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u5206\u6790\u663e\u793a\uff0c\u4ed6\u4eec\u5728\u4f53\u5916\u76f4\u63a5\u68c0\u6d4b\u5230\u4e86\u591a\u4e2aCD8+<\/sup> T\u7ec6\u80de\u53cd\u5e94\uff08\u5bf9\u4e8e32\u4e2a\u6d4b\u8bd5\u7684\u80bd\u6bb5\u4e2d\u76845\u4e2a\uff09\uff0c\u5e76\u5728\u4f53\u5916\u523a\u6fc0\u6269\u589e\u540e\u68c0\u6d4b\u5230\u4e86\u66f4\u591a\u7684CD8+ <\/sup>T\u7ec6\u80de\uff08\u5bf9\u4e8e32\u4e2a\u80bd\u6bb5\u4e2d\u768419\u4e2a\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7814\u7a76\u603b\u7ed3\u4e2d\uff0cAmigorena\u63cf\u8ff0\u4e86\u4ed6\u4e0eMNEMO Therapeutics\u7684\u5408\u4f5c\uff0c\u4ed6\u4eec\u7684\u76ee\u6807\u662f\u53d1\u73b0\u9488\u5bf9\u4e0eHLA\u5206\u5b50\u5448\u9012\u7684\u4eba\u7c7bJETs\u80bd\u6bb5\u7684\u5355\u94fe\u6297\u4f53\uff0c\u4ece\u800c\u5f00\u53d1\u51fa\u5177\u6709T\u7ec6\u80de\u53cc\u7279\u5f02\u6027\u548cCAR T\u7ec6\u80de\u7684\u65b0\u578b\u836f\u7269\u3002\u6fc0\u52a8\u4eba\u5fc3\u7684\u6570\u636e\u8868\u660e\uff0c\u4ed6\u4eec\u5df2\u7ecf\u5728\u81ea\u7136\u8868\u8fbe\u7684\u7ec6\u80de\u7cfb\u4e2d\uff0c\u4ee5\u53ca\u4f53\u5916\u548c\u4f53\u5185\u7684\u5b9e\u9a8c\u4e2d\uff0c\u5b9e\u73b0\u4e86\u8d85\u9ad8\u5206\u8fa8\u7387\u7684\u514d\u75ab\u8367\u5149\u68c0\u6d4b\uff0c\u5c55\u73b0\u51fa\u4e86\u8fd9\u79cd\u7b56\u7565\u7684\u53ef\u884c\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2. \u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u65e0\u6240\u4e0d\u5728\u7684\u764c\u80ce\u7cd6\u80fa\u805a\u7cd6<\/strong><\/p>\n<\/section>\n

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Ali Salanti – \u54e5\u672c\u54c8\u6839\u5927\u5b66\uff0c\u4e39\u9ea6\u54e5\u672c\u54c8\u6839<\/strong><\/p>\n<\/section>\n

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\u963f\u91cc\u00b7\u8428\u5170\u8482\uff08Ali Salanti\uff09\u662f\u4e00\u4f4d\u759f\u75be\u7814\u7a76\u8005\uff0c\u4ed6\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u505a\u51fa\u4e86\u4e00\u9879\u5f15\u4eba\u5165\u80dc\u7684\u53d1\u73b0\u3002\u4ed6\u53d1\u73b0\uff0c\u6076\u6027\u759f\u539f\u866b\u80fd\u591f\u5728\u611f\u67d3\u7684\u7ea2\u7ec6\u80de\u4e2d\u8868\u8fbe\u4e00\u79cd\u540d\u4e3aVAR2CSA\u7684\u7279\u6709\u759f\u75be\u7f16\u7801\u7ec6\u80de\u8868\u9762\u86cb\u767d\u3002\u8fd9\u79cd\u86cb\u767d\u8d28\u53ef\u4ee5\u4e0e\u5728\u80ce\u513f\u53d1\u80b2\u671f\u95f4\u4ec5\u5728\u80ce\u76d8\u4e2d\u8868\u8fbe\u7684\u7279\u5b9a\u7c7b\u578b\u8f6f\u9aa8\u786b\u9178\u916f\uff08CS\uff09\u7ed3\u5408\uff0c\u4e3a\u5bc4\u751f\u866b\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u751f\u5b58\u7a7a\u95f4\uff0c\u4f7f\u5176\u80fd\u591f\u907f\u514d\u5728\u813e\u810f\u4e2d\u88ab\u6e05\u9664\u3002\u80ce\u76d8\u4e2d\u7684\u8fd9\u79cd\u72ec\u7279CS\u6a21\u5f0f\u53ef\u4ee5\u5f62\u6210\u7ec6\u80de\u56e0\u5b50\u7684\u50a8\u5b58\u5e93\uff0c\u4fc3\u4f7f\u5feb\u901f\u4fb5\u5bb3\u6027\u751f\u957f\uff0c\u5e76\u4f7f\u6ecb\u517b\u5c42\u514d\u53d7\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u8fd9\u79cd\u7279\u6b8a\u7684CS\u7279\u5f81\u4e5f\u51fa\u73b0\u5728\u6076\u6027\u80bf\u7624\u7ec6\u80de\u4e2d\u3002\u5df2\u7ecf\u8bc1\u660e\uff0c\u91cd\u7ec4\u7684VAR2CSA\uff08rVAR2\uff09\u53ef\u4ee5\u4e0e\u51e0\u4e4e\u6240\u6709\u7c7b\u578b\u7684\u80bf\u7624\u7ec6\u80de\u7ed3\u5408\uff0c\u4f46\u4e0e\u6b63\u5e38\u7ec6\u80de\uff08\u9664\u80ce\u76d8\u5916\uff09\u7684\u7ed3\u5408\u51e0\u4e4e\u6ca1\u6709\uff0c\u8fd9\u5c06\u590d\u6742\u7684\u7ee7\u53d1\u6027CS\u4fee\u9970\u6807\u8bc6\u4e3a\u4e00\u4e2a\u80ce\u513f\u578b\u80bf\u7624\u6297\u539f\uff08ofCS\uff09\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7684rVAR2\u80fd\u5b9a\u4f4d\u5230\u80bf\u7624\uff0c\u5e76\u5f53\u4e0e\u5fae\u7ba1\u6291\u5236\u5242MMAE\u7ed3\u5408\u65f6\uff0c\u80fd\u591f\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u964d\u4f4e\u759f\u75be\u86cb\u767d\u7684\u514d\u75ab\u539f\u6027\u5e76\u5ef6\u957f\u6b64\u7c7b\u6cbb\u7597\u7684\u534a\u8870\u671f\uff0c\u8428\u5170\u8482\u81f4\u529b\u4e8e\u5f00\u53d1\u9488\u5bf9ofCS\u7684\u7279\u5f02\u6027\u6297\u4f53\u3002\u5c3d\u7ba1\u5728\u8bb8\u591a\u7269\u79cd\u4e2d\u5bfb\u627e\u8fd9\u79cd\u6297\u4f53\u663e\u5f97\u6781\u5177\u6311\u6218\u6027\uff0c\u4f46\u8428\u5170\u8482\u548c\u4ed6\u7684\u56e2\u961f\u6700\u7ec8\u6210\u529f\u7b5b\u9009\u51fa\u5927\u91cf\u7684\u566c\u83cc\u4f53\u5c55\u793a\u6587\u5e93\uff0c\u5e76\u9274\u5b9a\u51fa\u4e24\u79cd\u5355\u514b\u9686\u6297\u4f53\uff0c\u5b83\u4eec\u80fd\u591f\u4e0e\u4eba\u7c7b\u548c\u5c0f\u9f20\u7684ofCS\u5177\u6709\u9ad8\u4eb2\u548c\u6027\u548c\u7279\u5f02\u6027\u7ed3\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u66f4\u52a0\u7cbe\u51c6\u7684\u5b9e\u9a8c\u7ed3\u679c\u786e\u8ba4\uff0cofCS scFv\u53ef\u4ee5\u4e0e\u6076\u6027\u7ec4\u7ec7\u4e2d\u7684\u7ec6\u80de\u57fa\u8d28\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7ed3\u5408\uff0c\u4f46\u5728\u542b\u6709\u9ad8\u91cfCS\u7684\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u5e76\u672a\u51fa\u73b0\u7ed3\u5408\u3002\u6b64\u5916\uff0c\u8840\u6db2\u7cfb\u7edf\u80bf\u7624\u4e5f\u88ab\u53d1\u73b0\u8868\u8fbeofCS\uff0c\u8428\u5170\u8482\u5c55\u793a\u4e86\u6297ofCS\u4e0e\u4eba\u7c7b\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u7684\u7ed3\u5408\uff0c\u800c\u4e0d\u662f\u4e0e\u6b63\u5e38\u9aa8\u9ad3\u7684\u7ed3\u5408\u3002\u5728\u60a3\u6709\u80f0\u817a\u764c\u7684\u57fa\u56e0\u5de5\u7a0bKpC\u5c0f\u9f20\u4e2d\uff0cofCS scFvs\u80fd\u591f\u6807\u8bb0\u65e9\u671f\u80bf\u7624\u8d77\u59cb\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u9610\u660eofCS\u5728\u80bf\u7624\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\uff0c\u8428\u5170\u8482\u548c\u4ed6\u7684\u56e2\u961f\u6572\u9664\u4e86\u4e00\u79cd\u7528\u4e8e\u751f\u6210ofCS\u6240\u9700\u7684\u9176\u3002\u6572\u9664\u8fd9\u79cd\u9176\u7684\u80bf\u7624\u53d1\u73b0CD3+<\/sup>\u7ec6\u80de\u7684\u6d78\u6da6\u66f4\u4e25\u91cd\uff0c\u5b50\u7fa4\u5206\u6790\u663e\u793a\u4ece\u6d78\u6da6\u4e2d\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u5411CD4+<\/sup>\u548cCD8+ <\/sup>T\u7ec6\u80de\u7684\u663e\u8457\u8f6c\u53d8\uff0c\u5e76\u4e14\u80bf\u7624\u751f\u957f\u51cf\u5c11\uff0c\u8fd9\u8868\u660eofCS\u5728\u80bf\u7624\u514d\u75ab\u9003\u9038\u4e2d\u53d1\u6325\u4e86\u5173\u952e\u89d2\u8272\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5f53\u5c06\u6297ofCS scFvs\u4e0e\u5fae\u7ba1\u6291\u5236\u5242MMAE\u6216\u6297CD3 scFv\uff08\u751f\u6210\u4e00\u79cd\u5177\u6709\u53cc\u7279\u5f02\u6027\u7684T\u7ec6\u80de\u7ed3\u5408\u6297\u4f53\uff09\u7ed3\u5408\u540e\uff0c\u5728\u4f53\u5185\u663e\u793a\u51fa\u80bf\u7624\u5b9a\u4f4d\u548c\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5305\u62ec\u4ea7\u751f\u514d\u75ab\u8bb0\u5fc6\u3002\u5728\u8fd9\u4e9b\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u4f53\u91cd\u51cf\u8f7b\u7684\u73b0\u8c61\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u76ee\u524d\uff0c\u5df2\u7ecf\u8ba1\u5212\u8fdb\u884c0\u671f\u7814\u7a76\uff0c\u4ee5\u786e\u5b9a\u836f\u7269\u7684\u5242\u91cf\u548c\u836f\u4ee3\u52a8\u529b\u5b66\uff0c\u4e3a\u4e4b\u540e\u76841\u671f\u8bd5\u9a8c\u63d0\u4f9b\u5fc5\u8981\u7684\u4fe1\u606f\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8428\u5170\u8482\u7684\u8fd9\u9879\u7814\u7a76\u4e3a\u6211\u4eec\u7406\u89e3\u80bf\u7624\u7684\u53d1\u5c55\u4e0e\u514d\u75ab\u9003\u9038\u673a\u5236\uff0c\u4ee5\u53ca\u5f00\u53d1\u65b0\u7684\u6297\u80bf\u7624\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n


<\/p>\n

\n

3. \u9488\u5bf9\u6210\u4eba\u5f25\u6f2b\u6027\u4e2d\u7ebf\u80f6\u8d28\u7624\u60a3\u8005\u514b\u9686\u9a71\u52a8\u7a81\u53d8H3K27M\u7684\u957f\u80bd\u75ab\u82d7<\/strong><\/p>\n<\/section>\n

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Niklas Grassl – \u5fb7\u56fd\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3DKFZ\uff0c\u5fb7\u56fd\u6d77\u5fb7\u5821<\/strong>
<\/p>\n<\/section>\n

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\u5e7f\u6cdb\u4e2d\u7ebf\u80f6\u8d28\u7624\uff08Diffuse Midline Glioma\uff0cDMG\uff09\u4e3b\u8981\u53d1\u751f\u5728\u513f\u7ae5\u548c\u5e74\u8f7b\u6210\u4eba\u4e2d\uff0c\u603b\u4f53\u751f\u5b58\u671f\u5927\u7ea6\u53ea\u67099\u4e2a\u6708\u3002\u5176\u4e2d\u4e00\u79cd\u5e38\u89c1\u7684\u7a81\u53d8\u662f\u7ec4\u86cb\u767dH3 K27M\uff0c\u8fd9\u662f\u4e00\u79cd\u5728DMG\u4e2d\u53cd\u590d\u51fa\u73b0\u7684\u9a71\u52a8\u6027\u7a81\u53d8\u3002\u7814\u7a76\u8868\u660e\uff0c\u9488\u5bf9\u957fH3K27M\u80bd\u7684\u75ab\u82d7\u53ef\u4ee5\u6291\u5236H3K27M\u9633\u6027\u80bf\u7624\u5728MHC\u4eba\u6e90\u5316\u5c0f\u9f20\u4f53\u5185\u76ae\u4e0b\u79fb\u690d\u540e\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3c\u514b\u62c9\u65af\u00b7\u683c\u62c9\u65af\u5c14\uff08Niklas Grassl\uff09\u5728\u4e00\u4e2a\u9996\u6b21\u4eba\u4f53\u8bd5\u9a8c\u4e2d\uff0c\u9488\u5bf98\u540d\u60a3\u6709\u8fdb\u884c\u6027DMG\u7684\u5e74\u8f7b\u6210\u4eba\u8fdb\u884c\u4e86H3K27M\u957f\u80bd\u75ab\u82d7\u7684\u5b9e\u9a8c\uff0c\u5176\u4e2d4\u540d\u60a3\u8005\u540c\u65f6\u63a5\u53d7\u4e86\u6297PD-1\u6cbb\u7597\u3002\u8fd9\u79cd\u6cbb\u7597\u88ab\u826f\u597d\u5730\u8010\u53d7\uff0c\u800c\u552f\u4e00\u4e0e\u75ab\u82d7\u76f8\u5173\u7684\u526f\u4f5c\u7528\u662f\u6ce8\u5c04\u90e8\u4f4d\u7684\u53cd\u5e94\u3002\u63a5\u79cd\u540e\uff0c8\u540d\u60a3\u8005\u4e2d\u67095\u540d\u4ea7\u751f\u4e86\u9488\u5bf9H3 K27M\u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u8868\u73b0\u51fa\u5bf9\u7a81\u53d8\u80bd\u7684\u7279\u5f02\u6027\u3002\u5e76\u672a\u89c2\u5bdf\u5230\u4e0eHLA\u7c7b\u578b\u7684\u660e\u663e\u5173\u8054\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e2a\u5c0f\u7ec4\u7684\u603b\u4f53\u751f\u5b58\u671f\u8fbe\u5230\u4e86\u4ee4\u4eba\u9f13\u821e\u768412.8\u4e2a\u6708\u3002\u57285\u540d\u8868\u73b0\u51fa\u75ab\u82d7\u8bf1\u5bfc\u7684T\u7ec6\u80de\u53cd\u5e94\u7684\u60a3\u8005\u4e2d\uff0c\u67094\u540d\u51fa\u73b0\u4e86\u80bf\u7624\u7684\u5feb\u901f\u6682\u65f6\u6027\u7f29\u5c0f\uff0c\u5176\u4e2d\u4e00\u540d\u60a3\u8005\u5728\u63a5\u79cd\u540e\u768430\u4e2a\u6708\u540e\u4ecd\u5b58\u6d3b\uff0c\u5e76\u4e14\u51fa\u73b0\u4e86\u65e9\u671f\u7684\u80bf\u7624\u4f2a\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u901a\u8fc7\u8fd1\u8ddd\u79bb\u8fde\u63a5\u8bd5\u9a8c\u548c\u80bd\u6fc0\u6d3b\u8bd5\u9a8c\u4e2d\u7684\u6297MHC-II\u963b\u65ad\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u8bc6\u522bHLA-DR\u7684CD4+ <\/sup>T\u7ec6\u80de\u5728\u75ab\u82d7\u53cd\u5e94\u4e2d\u8d77\u4e86\u5173\u952e\u4f5c\u7528\u3002\u901a\u8fc7\u4ece\u957f\u671f\u751f\u5b58\u60a3\u8005\u7684\u5916\u5468\u8840\u4e2d\u6269\u589e\u7684\u7a81\u53d8\u80bd\u6269\u589eT\u7ec6\u80de\uff0c\u7814\u7a76\u8005\u9274\u5b9a\u51fa\u591a\u4e2a\u5177\u6709\u6297\u539f\u53cd\u5e94\u6027\u7684T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u514b\u9686\u3002\u63a5\u79cd\u540e\uff0c\u8fd9\u4e9b\u6269\u589e\u7684\u514b\u9686\u5728\u60a3\u8005\u7684\u5916\u5468\u8840\u548c\u8111\u810a\u6db2\u4e2d\u7684CD4+ <\/sup>T\u7ec6\u80de\u4e2d\u7684\u9891\u7387\u663e\u8457\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u540e\uff0c\u683c\u62c9\u65af\u5c14\u6307\u51fa\uff0c\u4ed6\u4eec\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u5c06H3 K27M\u80bd\u75ab\u82d7\u3001\u653e\u5c04\u6cbb\u7597\u548c\u6297PD-L1\u6297\u4f53\u7ed3\u5408\u7528\u4e8e\u65b0\u8bca\u65ad\u7684H3\u7a81\u53d8\u80f6\u8d28\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4. \u9488\u5bf9\u68c0\u67e5\u70b9\u8010\u836f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u66ff\u4ee3\u5171\u4eab\u65b0\u6297\u539f(TEIPP)\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/p>\n

Marij Welters – \u83b1\u987f\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\uff0c\u8377\u5170\u83b1\u987f<\/span><\/strong><\/p>\n<\/section>\n

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\u5728\u5bfb\u627e\u65b0\u7684\u5171\u4eab\u6297\u539f\u6765\u6e90\u4ee5\u5e94\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u514d\u75ab\u6cbb\u7597\u8010\u836f\u6027\u65f6\uff0cMarij Welters\u63cf\u7ed8\u4e86\u4e00\u79cd\u5f31\u5316\u514d\u75ab\u9003\u9038\u673a\u5236\u7684\u7b56\u7565\u3002\u80bf\u7624\u501f\u52a9\u591a\u79cd\u65b9\u5f0f\u8eb2\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u6253\u51fb\uff0c\u4f46\u80bf\u7624\u7684\u9057\u4f20\u4e0d\u7a33\u5b9a\u6027\u548c\u514d\u75ab\u7cfb\u7edf\u5bf9\u5176\u5f3a\u70c8\u538b\u529b\u5e38\u5e38\u5bfc\u81f4\u6297\u539f\u5448\u9012\u964d\u4f4e\u3002\u8fd9\u901a\u5e38\u6d89\u53ca\u5230\u6297\u539f\u5448\u9012\u76f8\u5173\u7684\u8f6c\u8fd0\u86cb\u767d\uff08TAP\uff09\u7684\u4e0b\u8c03\uff0c\u963b\u65ad\u4e86\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff08MHC\uff09\u5bf9\u5178\u578b\u8868\u4f4d\u7684\u5448\u9012\u3002\u7136\u800c\uff0c\u7f3a\u4e4f\u5178\u578b\u7684TAP\u4f9d\u8d56\u8def\u5f84\u5141\u8bb8\u5176\u4ed6\u5728\u5185\u8d28\u7f51\u4e2d\u5b58\u5728\u7684\u80bd\u6bb5\u8fdb\u5165\u7ade\u4e89\uff0c\u4e0eMHC\u6210\u529f\u7ed3\u5408\u3002\u8fd9\u4e9b\u80bd\u6bb5\u88ab\u79f0\u4e3a\u4e0e\u80bd\u5904\u7406\u53d7\u635f\u76f8\u5173\u7684T\u7ec6\u80de\u8868\u4f4d\uff08TEIPP\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TEIPP\u6765\u6e90\u4e8e\u975e\u7a81\u53d8\u7684\u86cb\u767d\u8d28\u7ec4\uff0c\u4f46\u5b83\u4eec\u5df2\u6210\u529f\u907f\u5f00\u4e86\u4e2d\u67a2\u8010\u53d7\uff0c\u56e0\u6b64\u53ef\u80fd\u662f\u9ad8\u514d\u75ab\u539f\u6027\u7684\u5171\u4eab\u201c\u65b0\u6297\u539f\u201d\uff0c\u53ef\u7528\u4e8e\u5bf9\u6297\u4e00\u4e9b\u5df2\u7ecf\u9003\u9038\u7684\u80bf\u7624\u3002Welters\u7684\u56e2\u961f\u4e3aNSCLC\u6837\u672c\u5efa\u7acb\u4e86\u4e00\u4e2a\u6d41\u7a0b\uff0c\u9884\u6d4bN\u672b\u7aef\u4fe1\u53f7\u548cC\u672b\u7aef\u5c3e\u80bd\uff08\u5df2\u77e5\u662fTEIPP\u80bd\u7684\u5bcc\u96c6\u6e90\uff09\u4e0eMHC\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u5206\u6790TAP\u7f3a\u4e4f\u7684\u80bf\u7624\u7ec6\u80de\u548c\u6b63\u5e38\u5065\u5eb7\u7ec4\u7ec7\u7684\u514d\u75ab\u80bd\u8c31\uff0c\u5e76\u9274\u5b9a\u51fa\u53cd\u5e94\u6027T\u7ec6\u80de\u548cT\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u6b64\u7c7b\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u5df2\u6210\u529f\u9274\u5b9a\u51fa\u4e00\u79cd\u6765\u81eaLRPAP1\u7684\u80bd\u6bb5\uff0c\u4f5c\u4e3a\u5408\u6210\u957f\u80bd\uff08SLP\uff09\u75ab\u82d7\uff0c\u901a\u8fc7\u8fdb\u884c\u5f02\u6784\u6027\u951a\u5b9a\u6b8b\u57fa\uff08S>V\uff09\u7684\u6539\u53d8\uff0c\u5728\u4f53\u5916\u5bf9\u591a\u4e2a\u4f9b\u4f53\u5177\u6709\u9ad8\u514d\u75ab\u539f\u6027\u3002Welters\u63a5\u7740\u63cf\u8ff0\u4e86\u8fd1\u671f\u4e00\u9879\u4e34\u5e8a\u75ab\u82d7\u63a5\u79cd\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u9488\u5bf9\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u540e\u590d\u53d1\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u60a3\u8005\u57283\u5468\u95f4\u9694\u76843\u6b21\u63a5\u79cd\u4e2d\u4f7f\u7528Montanide\u4f50\u5242\u63a5\u79cdSLP\u3002\u5728\u524d\u4e24\u4e2a\u5242\u91cf\u6c34\u5e73\u4e0a\uff0c\u5df2\u7ecf\u8bc1\u660e\u4e86\u5176\u5b89\u5168\u6027\u3002\u5728\u63a5\u79cd\u768412\u540d\u60a3\u8005\u4e2d\uff0c\u67097\u540d\u60a3\u8005\u8868\u73b0\u51fa\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u4e34\u5e8a\u53cd\u5e94\uff0c\u5e76\u4e14\u901a\u8fc7\u4f7f\u7528dextramer\u67d3\u8272\u548c\u5916\u5468\u8840\u7ec6\u80de\u5185\u7ec6\u80de\u56e0\u5b50\u67d3\u8272\uff0c\u68c0\u6d4b\u5230\u4e86\u9488\u5bf9LRPAP1\u7684\u7279\u5f02\u6027\u591a\u529f\u80fdCD8+<\/sup>\u548cCD4+ <\/sup>T\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u4e00\u4e2aNSCLC\u80bf\u7624\u7ec6\u80de\u7cfb\u4e2d\uff0c\u901a\u8fc7\u6572\u9664TAP1\uff0c\u53ef\u4ee5\u4f7f\u8fd9\u4e9b\u7ecf\u8fc7\u6539\u9020\u7684\u80bf\u7624\u7ec6\u80de\u88ab\u4e00\u540d\u63a5\u79cd\u60a3\u8005\u7684\u5df2\u6392\u5e8f\u7684CD8+<\/sup>Dextramer+ <\/sup>PBMCs\u8bc6\u522b\uff0c\u4ece\u800c\u652f\u6301TEIPP\u75ab\u82d7\u63a5\u79cd\u4f5c\u4e3a\u5bf9\u514d\u75ab\u9003\u9038\u80bf\u7624\u7684\u6f5c\u5728\u633d\u6551\u7597\u6cd5\uff0c\u8fd9\u7c7b\u80bf\u7624\u7684\u6297\u539f\u5904\u7406\u673a\u5236\u5df2\u53d7\u635f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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5. cDC1\u5728\u80ba\u764c\u4e2d\u9a71\u52a8\u5bf9\u5185\u6e90\u6027\u514d\u75ab\u539f\u6027\u65b0\u6297\u539f\u7684\u6297\u80bf\u7624\u514d\u75ab<\/span><\/strong><\/p>\n

Federica Benvenuti – \u56fd\u9645\u9057\u4f20\u5de5\u7a0b\u4e0e\u751f\u7269\u6280\u672f\u4e2d\u5fc3\uff0c\u610f\u5927\u5229\u7279\u91cc\u65af\u7279<\/span><\/strong><\/p>\n<\/section>\n

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Federica Benvenuti\u7684\u7814\u7a76\u7740\u91cd\u4e8e\u7c7b\u578b1\u6811\u7a81\u72b6\u7ec6\u80de\uff08cDC1\uff09\u5728\u9009\u62e9\u4ee5\u53ca\u4ea7\u751f\u5bf9\u80bf\u7624\u65b0\u6297\u539f\u7684\u6709\u6548CD8+ <\/sup>T\u7ec6\u80de\u53cd\u5e94\u4e2d\u7684\u89d2\u8272\u3002Benvenuti\u9996\u5148\u901a\u8fc7\u5728KPcontrol<\/sup>\uff08rasG12D<\/sup>\/Trp53loss<\/sup>\uff09\u7ec6\u80de\u4e2d\u6572\u9664DNA\u4fee\u590d\u9014\u5f84\u7684\u5173\u952e\u9176Mlh1\uff0c\u751f\u6210\u4e86\u4e00\u4e2a\u65b0\u7684\u7ec6\u80de\u7cfbKPneo<\/sup>\uff0c\u8fd9\u4e2a\u7ec6\u80de\u7cfb\u8868\u8fbe\u4e86\u975e\u66ff\u4ee3\u6027\u7684\u771f\u6b63\u65b0\u6297\u539f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728KPneo<\/sup>\u7ec6\u80de\u7cfb\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9274\u5b9a\u51fa\u4e8626\u4e2a\u65b0\u7684\u6297\u539f\u8868\u4f4d\u3002\u5c06KPneo<\/sup>\u7ec6\u80de\u690d\u5165\u5230\u5177\u5907\u6b63\u5e38\u514d\u75ab\u529f\u80fd\u7684\u5c0f\u9f20\u4f53\u5185\u540e\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u4e0eKP\u80bf\u7624\u7ec6\u80de\u7cfb\u76f8\u6bd4\uff0c\u4f9d\u8d56\u4e8eCD8+ <\/sup>T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u514d\u75ab\u80fd\u591f\u5ef6\u7f13\u80bf\u7624\u7684\u751f\u957f\uff0c\u80bf\u7624\u5185\u90e8\u7684CD8+<\/sup>IFN\u03b3+ <\/sup>T\u7ec6\u80de\u6570\u91cf\u5927\u5e45\u589e\u52a0\u3002\u540c\u65f6\uff0c\u591a\u4e2a\u65b0\u6297\u539f\u8868\u4f4d\u80fd\u591f\u89e6\u53d1T\u7ec6\u80de\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5206\u6790\u80bf\u7624\u5185\u7684cDC1s\u663e\u793a\uff0c\u4e0eKPcontrol<\/sup>\u80bf\u7624\u76f8\u6bd4\uff0cKPneo<\/sup>\u80bf\u7624\u4e2d\u7684cDC1\u6570\u91cf\u663e\u8457\u589e\u52a0\u3002\u901a\u8fc7\u5220\u9664cDC1\u4e9a\u7fa4\uff08Batf3 KO\uff09\u53d1\u73b0\uff0c\u65b0\u6297\u539f\u5bf9T\u7ec6\u80de\u6570\u91cf\u548c\u8868\u578b\u7684\u5f71\u54cd\u5b8c\u5168\u4f9d\u8d56\u4e8ecDC1\u7684\u5b58\u5728\u3002\u5411\u80bf\u7624\u76f4\u63a5\u6ce8\u5c04Flt3\u914d\u4f53\u548cpolyI:C\u4f1a\u589e\u52a0KPneo<\/sup>\u80bf\u7624\u5bf9\u6297PD-L1\u6cbb\u7597\u7684\u654f\u611f\u6027\uff0c\u7136\u800c\uff0cKPcontrol<\/sup>\u80bf\u7624\u5bf9\u6b64\u5e76\u4e0d\u654f\u611f\u3002\u6839\u636e\u5728XCR1DTA<\/sup>\u5c0f\u9f20\u4e2d\u5f97\u5230\u7684\u7ed3\u679c\uff0c\u8fd9\u79cd\u6548\u5e94\u9700\u8981cDC1\u7684\u5b58\u5728\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5206\u6790\u4eba\u7c7b\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6570\u636e\u53d1\u73b0\uff0c\u76f8\u6bd4\u4e8e\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u8f83\u4f4e\u7684\u60a3\u8005\uff0cTMB\u8f83\u9ad8\u7684\u60a3\u8005\u4e2dcDC1\u548cCD8\u6548\u5e94\u6807\u5fd7\u5747\u8f83\u9ad8\uff0c\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u652f\u6301\u4e86KPneo<\/sup>\u548cKPcontrol<\/sup>\u5c0f\u9f20\u6a21\u578b\u7684\u7814\u7a76\u7ed3\u679c\u3002\u5728\u80ba\u90e8\u6b63\u4f4d\u690d\u5165\u7684KPneo<\/sup>\u80bf\u7624\u5bf9\u6297PD-L1\u6cbb\u7597\u7684\u53cd\u5e94\u8f83\u5f31\uff0c\u4f46\u901a\u8fc7\u4f7f\u7528Flt3L\u548c\u6fc0\u52a8\u5242CD40\u6297\u4f53\uff08Flt3L\/agOX40\uff09\u523a\u6fc0DC\uff0c\u80bf\u7624\u7684\u751f\u957f\u663e\u8457\u53d7\u5230\u6291\u5236\uff0c\u5bf9KPneo<\/sup>\u65b0\u6297\u539f\u7684\u53cd\u5e94\u663e\u8457\u589e\u5f3a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8868\u8fbeXCR1-venus\u7684\u62a5\u544a\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u6cbb\u7597\u540e\uff0cKPneo<\/sup>\u80bf\u7624\u4e2d\u6d78\u6da6\u7684cDC1\u548cCD8+ <\/sup>T\u7ec6\u80de\u540c\u65f6\u589e\u52a0\u3002\u5bf9\u672a\u7ecf\u5904\u7406\u548c\u7ecf\u8fc7Flt3L\/agOX40\u5904\u7406\u7684\u80bf\u7624\u4e2d\u7684CD8+ <\/sup>T\u7ec6\u80de\u8fdb\u884c\u5355\u7ec6\u80de\u5206\u6790\u663e\u793a\uff0c\u7ec6\u80de\u4e9a\u7fa4\u7684\u9891\u7387\u5b58\u5728\u5dee\u5f02\uff0c\u5e76\u4e14\u7ecf\u8fc7\u5904\u7406\u7684\u80bf\u7624\u4e2d\uff0c\u7ec6\u80de\u7684\u6bd2\u6027\u53ca\u589e\u6b96\u80fd\u529b\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9cDC\u4e9a\u7fa4\u7684\u5206\u6790\u663e\u793a\uff0c\u5728\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0cmregDCs\u5927\u91cf\u51cf\u5c11\uff0c\u800ccDC1\u548ccDC2\u4e9a\u7fa4\u6574\u4f53\u4e0a\u5411\u8f83\u5c11\u8017\u7aed\/\u8010\u53d7\u539f\u72b6\u6001\u8f6c\u53d8\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u80bf\u7624\u5185\u7684DC\u4e9a\u7fa4\u5bf9\u54cd\u5e94\u7684CD8+ <\/sup>T\u7ec6\u80de\u7684\u79cd\u7c7b\u53ca\u5176\u6297\u80bf\u7624\u529f\u80fd\u7684\u8d28\u91cf\u90fd\u6709\u663e\u8457\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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6. \u80f0\u817a\u764c – \u4ece\u4e34\u5e8a\u53d1\u73b0\u5230\u65b0\u7684\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/p>\n

Vinod Balachandran – \u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff0c\u7f8e\u56fd\u67e5\u5c14\u65af\u987f<\/span><\/strong><\/p>\n<\/section>\n

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Vinod Balachandran\u7684\u7814\u7a76\u9886\u57df\u4e13\u6ce8\u4e8e\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u5178\u578b\u7684\u514d\u75ab”\u51b7”\u7624\uff0c\u5176\u7279\u70b9\u662f\u7a81\u53d8\u8d1f\u62c5\u8f83\u4f4e\u3001T\u7ec6\u80de\u6d78\u6da6\u8f83\u5c11\u4e14\u5bf9\u514d\u75ab\u7597\u6cd5\u5177\u6709\u62b5\u6297\u6027\u3002\u7136\u800c\uff0c\u5927\u7ea69%\u7684PDAC\u80bf\u7624\u662f\u514d\u75ab”\u70ed”\u7624\uff0c\u60a3\u6709\u8fd9\u79cd\u80bf\u7624\u7684\u60a3\u8005\u5177\u6709\u8f83\u9ad8\u7684\u751f\u5b58\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u786e\u5b9a\u5982\u4f55\u6700\u6709\u6548\u5730\u6fc0\u53d1\u65b0\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u589e\u5f3a\u5df2\u6709\u7684\u514d\u75ab\u5e94\u7b54\uff0c\u6216\u8005\u540c\u65f6\u5b9e\u73b0\u8fd9\u4e24\u4e2a\u76ee\u6807\uff0cBalachandran\u548c\u4ed6\u7684\u56e2\u961f\u5f00\u53d1\u4e86\u4e00\u4e2a\u8bc4\u4f30\u65b0\u6297\u539f\u8d28\u91cf\u7684\u6a21\u578b\u3002\u8fd9\u4e2a\u6a21\u578b\u901a\u8fc7\u9884\u6d4bMHC\u7ed3\u5408\u3001\u6f5c\u5728\u7684T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u53cd\u5e94\u6027\u4ee5\u53ca\u4e0e\u5df2\u77e5\u75c5\u6bd2\u6297\u539f\u80bd\u7684\u76f8\u4f3c\u6027\uff0c\u6765\u4f30\u8ba1\u6297\u539f\u7684”\u81ea\u8eab\u6027”\u548c”\u975e\u81ea\u8eab\u6027”\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u65b0\u6297\u539f\u7684\u8d28\u91cf\u800c\u975e\u6570\u91cf\u66f4\u80fd\u6709\u6548\u5730\u9884\u6d4b\u60a3\u8005\u7684\u751f\u5b58\u7387\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u9ad8\u8d28\u91cf\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53ef\u4ee5\u5728\u4e00\u4e9b\u80f0\u817a\u764c\u7684\u957f\u671f\u751f\u5b58\u8005\u7684\u8840\u6db2\u4e2d\u88ab\u68c0\u6d4b\u5230\uff0c\u751a\u81f3\u53ef\u4ee5\u6301\u7eed\u5b58\u5728\u957f\u8fbe\u5341\u5e74\u4e4b\u4e45\u3002\u5728\u8fd9\u4e9b\u957f\u671f\u751f\u5b58\u8005\u7684\u590d\u53d1\u6027\u80bf\u7624\u4e2d\uff0c\u9ad8\u8d28\u91cf\u7684\u65b0\u6297\u539f\u5f88\u53ef\u80fd\u4f1a\u88ab\u7f16\u8f91\uff0c\u800c\u81ea\u53d1\u4ea7\u751f\u7684\u9ad8\u8d28\u91cf\u65b0\u6297\u539f\u53ef\u80fd\u4f1a\u5f15\u53d1\u589e\u52a0\u7684\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\uff0c\u4ece\u800c\u5ef6\u7f13\u80bf\u7624\u7684\u590d\u53d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Balachandran\u548c\u4ed6\u7684\u56e2\u961f\u60f3\u8981\u63a2\u7d22\u662f\u5426\u53ef\u4ee5\u4f7f\u7528RNA\u75ab\u82d7\u6765\u6fc0\u53d1\u65b0\u7684\u514d\u75ab\u5e94\u7b54\u3002\u5728\u4e00\u9879\u5408\u4f5c\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u9488\u5bf9\u80f0\u817a\u764c\u7684\u4e2a\u6027\u5316mRNA\u75ab\u82d7\u3002\u4ed6\u4eec\u8fdb\u884c\u4e86\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2d\u60a3\u8005\u5728\u624b\u672f\u540e\u7684\u7b2c6\u5468\u63a5\u53d7atezolizumab\u6cbb\u7597\uff0c\u7136\u540e\u4ece\u7b2c9\u5468\u5f00\u59cb\u8fde\u7eed8\u6b21\u63a5\u79cd\u4e2a\u6027\u5316\u764c\u75c7\u75ab\u82d7\uff0c\u63a5\u7740\u4ece\u7b2c21\u5468\u5f00\u59cb\u63a5\u53d7\u6807\u51c6\u5316\u7597\uff0c\u5e76\u5728\u7b2c46\u5468\u8fdb\u884c\u6700\u540e\u7684\u8fdf\u53d1\u6027\u589e\u5f3a\u6cbb\u7597\u3002\u5c3d\u7ba1COVID-19\u5927\u6d41\u884c\u5bf9\u8fd9\u9879\u8bd5\u9a8c\u9020\u6210\u4e86\u5e72\u6270\uff0c\u4f46\u4ecd\u670916\u540d\u63a5\u53d7atezolizumab\u6cbb\u7597\u768419\u540d\u60a3\u8005\u7ee7\u7eed\u63a5\u53d7\u75ab\u82d7\u63a5\u79cd\uff0c\u8fd9\u8bc1\u5b9e\u4e86\u624b\u672f\u540e\u751f\u6210\u548c\u4f7f\u7528\u5b9a\u5236\u75ab\u82d7\u7684\u53ef\u884c\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u901a\u8fc7\u4e3b\u8981\u7684ELISpot\u5206\u6790\u548c\u786e\u8ba4\u6027TCR\u6d4b\u5e8fCloneTrack\u6d4b\u8bd5\uff0c\u4ed6\u4eec\u76d1\u6d4b\u4e86\u75ab\u82d7\u8bf1\u5bfc\u7684T\u7ec6\u80de\u5e94\u7b54\uff0c\u5e76\u53d1\u73b0\u5728\u5316\u7597\u540e\uff0c\u5f3a\u5927\u7684\u75ab\u82d7\u8bf1\u5bfc\u5e94\u7b54\u4ecd\u80fd\u88ab\u4fdd\u6301\u3002\u57fa\u4e8e\u5916\u5468\u8840\u4e2d\u75ab\u82d7\u8bf1\u5bfc\u7684\u514b\u9686\u8f68\u8ff9\u8fdb\u884c\u805a\u7c7b\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cmRNA\u75ab\u82d7\u6269\u589e\u7684\u591a\u514b\u9686T\u7ec6\u80de\u5e93\u5305\u62ec\u5728\u75ab\u82d7\u63a5\u79cd\u524d\u65e0\u6cd5\u68c0\u6d4b\u5230\u7684\u514b\u9686\uff0c\u4e0e\u6297PD-L1\u6269\u589e\u7684\u514b\u9686\u5e93\u660e\u663e\u4e0d\u540c\u3002\u8fd9\u79cd\u6548\u5e94\u5728\u75ab\u82d7\u589e\u5f3a\u5242\u540e\u66f4\u4e3a\u663e\u8457\uff0c\u8fdb\u4e00\u6b65\u6269\u5927\u4e86\u75ab\u82d7\u8bf1\u5bfc\u7684\u514b\u9686\uff0c\u800c\u975ePD-L1\u8bf1\u5bfc\u7684\u514b\u9686\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u4e00\u4e9b\u957f\u65f6\u95f4\u5b58\u6d3b\u7684\u60a3\u8005\u4f53\u5185\u5b58\u5728\u7684\u9ad8\u8d28\u91cf\u65b0\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u514b\u9686\u5728\u63a5\u53d7\u75ab\u82d7\u63a5\u79cd\u540e\u663e\u8457\u589e\u52a0\u3002\u8fd9\u4e9b\u7ed3\u679c\u90fd\u8868\u660e\uff0cmRNA\u75ab\u82d7\u53ef\u4ee5\u6269\u589e\u65b0\u7684\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0d\u4ec5\u5982\u6b64\uff0c\u62c9\u95e8\u897f\u6559\u6388\u8fd8\u5c06\u8fd9\u4e9b\u79d1\u7814\u6210\u679c\u8f6c\u5316\u4e3a\u5b9e\u9645\u5e94\u7528\uff0c\u7528\u4e8e\u4e2a\u6027\u5316\u6cbb\u7597\u80bd\u6bb5\u548cmRNA\u764c\u75c7\u75ab\u82d7\u7684\u8bbe\u8ba1\u3002\u4ed6\u7684\u7814\u7a76\u4ea6\u50ac\u751f\u4e86\u4e03\u5bb6\u516c\u53f8\uff0c\u5305\u62ecImmatics Biotechnologies\u548cCureVac\u7b49\u3002\u603b\u7684\u6765\u8bf4\uff0c\u62c9\u95e8\u897f\u6559\u6388\u5728\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u8d21\u732e\u5bf9\u4e8e\u79d1\u7814\u548c\u533b\u7597\u5b9e\u8df5\u90fd\u5177\u6709\u5e7f\u6cdb\u800c\u6df1\u8fdc\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u2014 THE  END \u2014<\/span><\/section>\n
\u6765\u6e90 | ACIR.ORG<\/span><\/section>\n
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ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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