{"id":3183,"date":"2023-06-29T14:27:27","date_gmt":"2023-06-29T06:27:27","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/06\/29\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%8d%a1%e4%bb%8b%e8%8b%97%e5%92%8c%e6%8a%97pd-l1%e6%8a%97%e4%bd%93%e5%9c%a8%e8%86%80%e8%83%b1%e8%82%bf%e7%98%a4%e4%b8%ad\/"},"modified":"2023-06-29T14:27:27","modified_gmt":"2023-06-29T06:27:27","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%8d%a1%e4%bb%8b%e8%8b%97%e5%92%8c%e6%8a%97pd-l1%e6%8a%97%e4%bd%93%e5%9c%a8%e8%86%80%e8%83%b1%e8%82%bf%e7%98%a4%e4%b8%ad","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/06\/29\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac22%e7%ab%a0%ef%bc%9a%e5%8d%a1%e4%bb%8b%e8%8b%97%e5%92%8c%e6%8a%97pd-l1%e6%8a%97%e4%bd%93%e5%9c%a8%e8%86%80%e8%83%b1%e8%82%bf%e7%98%a4%e4%b8%ad\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c22\u7ae0\uff1a\u5361\u4ecb\u82d7\u548c\u6297PD-L1\u6297\u4f53\u5728\u8180\u80f1\u80bf\u7624\u4e2d\u7684\u4f5c\u7528(\u4e0a\uff09"},"content":{"rendered":"
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22.1 \u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u662f\u5f53\u524d\u5907\u53d7\u5173\u6ce8\u7684\u764c\u75c7\u7814\u7a76\u9886\u57df\u3002\u5b83\u5df2\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u4e86\u6297\u80bf\u7624\u6d3b\u6027\u548c\u751f\u5b58\u4f18\u52bf\uff0c\u5305\u62ec\u8f6c\u79fb\u6027\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\uff08UC\uff09\u3002\u5b9e\u9645\u4e0a\uff0c\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597UC\u662f\u6709\u5145\u5206\u7406\u7531\u7684\uff0c\u56e0\u4e3aUC\u5df2\u7ecf\u4ece\u9759\u8109\u6ce8\u5c04\u5361\u4ecb\u82d7\uff08BCG\uff09\u7684\u514d\u75ab\u7597\u6cd5\u4e2d\u53d7\u76ca\u4e8640\u591a\u5e74\u3002\u5c3f\u8def\u4e0a\u76ae\u764c\u662f\u8bc1\u660e\u514d\u75ab\u68c0\u67e5\u70b9\u7597\u6cd5\u6709\u6548\u7684\u51e0\u79cd\u521d\u59cb\u764c\u75c7\u4e4b\u4e00\uff0c\u800c\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u76ee\u524d\u4ecd\u7136\u662f\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff08NMIBC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u5bf9\u4e8e\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u7814\u7a76\u8868\u660e\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u5c06\u6210\u4e3a\u6cbb\u7597\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u91cd\u8981\u7597\u6cd5\uff0c\u53ef\u7528\u4e8e\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u5404\u4e2a\u9636\u6bb5\uff0c\u4ee5\u6539\u5584\u60a3\u8005\u7684\u75c7\u72b6\u3002\u867d\u7136\u5728UC\u4e2d\u6709\u8bb8\u591a\u5176\u4ed6\u57fa\u4e8e\u514d\u75ab\u7684\u6cbb\u7597\u65b9\u6cd5\u6b63\u5728\u8fdb\u884c\u7814\u7a76\uff0c\u4f8b\u5982\u764c\u75c7\u75ab\u82d7\u548c\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff0c\u4f46\u672c\u7efc\u8ff0\u5c06\u91cd\u70b9\u4ecb\u7ecd\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea11\uff08PD-1\uff09\u548c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u6291\u5236\u5242\u5728UC\u4e2d\u7684\u5e94\u7528\uff0c\u5e76\u7b80\u8981\u4ecb\u7ecd\u5361\u4ecb\u82d7\u5728\u8180\u80f1\u764c\u4e2d\u7684\u53d1\u5c55\u5386\u53f2\u548c\u5e94\u7528\u3002\u8bf7\u6ce8\u610f\uff0c\u672c\u7ae0\u4e0d\u6d89\u53caPD-1\u548cPD-L1\u8f74\u7684\u751f\u7269\u5b66\u95ee\u9898\uff0c\u56e0\u4e3a\u540e\u7eed\u4f1a\u6709\u4e13\u95e8\u7684\u7ae0\u8282\u6765\u5173\u6ce8\u8fd9\u4e00\u9886\u57df\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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22.2  \u5361\u4ecb\u82d7\uff08BCG\uff09<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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22.2.1   BCG\u7684\u5f53\u524d\u9002\u5e94\u75c7<\/p>\n<\/section>\n

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\u514d\u75ab\u6cbb\u7597\u5728\u65e9\u671f\u8180\u80f1\u764c\u4e2d\u5df2\u7ecf\u5efa\u7acb\u4e8640\u5e74\uff0c\u5176\u4e2d\u9759\u8109\u5185\u6ce8\u5c04\u5361\u4ecb\u82d7\u7528\u4e8e\u975e\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u764c\uff08NMIBC\uff09\u662f\u6700\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u4e4b\u4e00\u3002\u5361\u4ecb\u82d7\u662f\u4e00\u79cd\u725b\u5206\u679d\u6746\u83cc\u51cf\u6bd2\u6d3b\u75ab\u82d7\uff0c\u6700\u521d\u662f\u4e3a\u9884\u9632\u7ed3\u6838\u75c5\u800c\u5f00\u53d1\u7684\u3002\u7ecf\u5c3f\u9053\u5207\u9664\u8180\u80f1\u80bf\u7624\uff08TURBT\uff09\u540e\u8fdb\u884c\u7684\u5361\u4ecb\u82d7\u514d\u75ab\u7597\u6cd5\u88ab\u8ba4\u4e3a\u662f\u514d\u75ab\u6cbb\u7597\u5728\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u6700\u6210\u529f\u7684\u5e94\u7528\u4e4b\u4e00\u3002<\/p>\n

\u5361\u4ecb\u82d7\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6f5c\u529b\u53ef\u4ee5\u8ffd\u6eaf\u52301929\u5e74\uff0c\u5f53\u65f6\u7684\u4e00\u9879\u7814\u7a76\u62a5\u544a\u79f0\uff0c\u7ed3\u6838\u75c5\u60a3\u8005\u7684\u764c\u75c7\u53d1\u75c5\u7387\u964d\u4f4e\u3002\u540e\u7eed\u7814\u7a76\u53d1\u73b0\uff0c\u8180\u80f1\u5bf9BCG\u7684\u53cd\u5e94\u4e0e\u76ae\u80a4\u4e0a\u7684\u8fdf\u53d1\u6027\u8d85\u654f\u53cd\u5e94\u96f7\u540c\u53d1\u751f\u3002\u4e00\u4e2a\u7ecf\u5178\u7684\u4e34\u5e8a\u75c5\u4f8b\u8868\u660e\uff0c\u76ae\u5185\u7684BCG\u6cbb\u7597\u5bf9\u8f6c\u79fb\u5230\u8180\u80f1\u7684\u9ed1\u8272\u7d20\u7624\u5177\u6709\u4e00\u5b9a\u7684\u7597\u6548\u3002\u8fd9\u4fc3\u4f7f\u7814\u7a76\u4eba\u5458\u5bf9\u5361\u4ecb\u82d7\u5728\u8180\u80f1\u764c\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u4f5c\u7528\u8fdb\u884c\u8bc4\u4f30\uff0c\u7ed3\u679c\u663e\u793a\u6bcf\u5468\u516d\u6b21\u9759\u8109\u5185\u52a0\u7ecf\u76ae\u7ed9\u836f\u53ef\u4f7f\u8180\u80f1\u80bf\u7624\u7684\u590d\u53d1\u7387\u964d\u4f4e12\u500d\u3002\u968f\u540e\u7684\u7b2c\u4e00\u4e2a\u5361\u4ecb\u82d7\u5bf9\u7167\u8bd5\u9a8c\u663e\u793a\uff0c\u572854\u540d\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u590d\u53d1\u7387\u6709\u660e\u663e\u7684\u4e0b\u964d\u3002\u5728\u98ce\u9669\u66f4\u5927\u7684\u60a3\u8005\u4e2d\u4e5f\u62a5\u544a\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u4e24\u9879Meta\u5206\u6790\u8868\u660e\uff0c\u5361\u4ecb\u82d7\u6cbb\u7597\u53ef\u4ee5\u9884\u9632\u6216\u81f3\u5c11\u5ef6\u7f13\u4e2d\u5ea6\u548c\u9ad8\u5ea6\u98ce\u9669\u7684NMIBC\u5728TURBT\u540e\u7684\u80bf\u7624\u8fdb\u5c55\u98ce\u9669\u3002<\/p>\n

\u76ee\u524d\uff0c\u5361\u4ecb\u82d7\u88ab\u63a8\u8350\u7528\u4e8e\u4e2d\u5371\u548c\u9ad8\u5371\u80bf\u7624\u60a3\u8005\uff083\u7ea7\u3001\u539f\u4f4d\u764c[CIS]\u3001T1\u671f\uff09\u3002\u4f7f\u7528\u5361\u4ecb\u82d7\u7684\u7406\u7531\u5305\u62ec\u9884\u9632\u6216\u5ef6\u7f13\u590d\u53d1\uff0c\u51cf\u5c11\u8fdb\u5c55\uff0c\u4ee5\u53ca\u907f\u514d\u6839\u6cbb\u6027\u8180\u80f1\u5207\u9664\u672f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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22.2.2   BCG\u7684\u4f5c\u7528\u673a\u5236<\/p>\n<\/section>\n

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\u5bf9\u4e8eBCG\u8bf1\u5bfc\u514d\u75ab\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u53cd\u5e94\u7684\u673a\u5236\u76ee\u524d\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002BCG\u53ef\u4ee5\u901a\u8fc7\u7279\u5f02\u6027\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d\u548c\u6574\u5408\u7d20\u53d7\u4f53\u4e0e\u8180\u80f1\u80bf\u7624\u7ec6\u80de\u548c\u5c3f\u8def\u4e0a\u76ae\u7ec6\u80de\u7c98\u9644\u5e76\u88ab\u5185\u5316\u3002\u5185\u5316\u7684BCG\u7279\u5f02\u6027\u6297\u539f\u4f1a\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff0c\u6b64\u65f6\u80bf\u7624\u7ec6\u80de\u4e0a\u7684\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53(MHC) II\u7c7b\u6297\u539f\u8868\u8fbe\u4e0a\u8c03\u3002\u7136\u800c\uff0cBCG\u7684\u7597\u6548\u9700\u8981\u4e00\u4e2a\u6709\u6548\u7684\u514d\u75ab\u7cfb\u7edf\u548c\u5177\u6709\u6297\u80bf\u7624\u514d\u75ab\u529f\u80fd\u7684T\u7ec6\u80de\u4e9a\u578b\uff08\u5982NK\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u7c92\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\uff09\uff0c\u4ee5\u53ca\u5404\u79cd\u7ec6\u80de\u56e0\u5b50\u548c\u767d\u7ec6\u80de\u4ecb\u7d20\u3002\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u88ab\u62db\u52df\u5230\u8180\u80f1\u5e76\u5728\u6cbb\u7597\u540e\u7684\u5c3f\u6db2\u4e2d\u5927\u91cf\u51fa\u73b0\u3002<\/p>\n

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\u5728BCG\u6cbb\u7597\u540e\uff0c\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u88ab\u8bf1\u5bfc\uff0c\u5305\u62ec\u767d\u7ec6\u80de\u4ecb\u7d20\uff08IL\uff09-1\u3001IL-2\u3001IL-6\u3001IL-8\u3001IL-10\u3001IL-12\u3001TNF-a\u3001\u5e72\u6270\u7d20\uff08IFN\uff09g\u3001\u7c92\u7ec6\u80de\/\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\u548c\u53ef\u6eb6\u6027\u7ec6\u80de\u95f4\u9ecf\u9644\u5206\u5b50I\u3002\u4e3a\u4e86\u83b7\u5f97\u6700\u4f73\u7597\u6548\uff0c\u5728\u60a3\u8005\u7b2c\u4e00\u6b21\u4f7f\u7528BCG\u6cbb\u7597\u540e\uff0c\u540e\u7eed\u6cbb\u7597\u4e2d\u4e5f\u8981\u6709\u8ba1\u5212\u5730\u7ee7\u7eed\u4f7f\u7528BCG\u3002EORTC-GU\u7ec4\u7684Meta\u5206\u6790\u8868\u660e\uff0c\u53ea\u6709\u6301\u7eed\u63a5\u53d7BCG\u6cbb\u7597\u7684\u60a3\u8005\u624d\u4f1a\u53d7\u76ca\uff0c\u4f46\u662f\u8fd9\u9879\u5206\u6790\u65e0\u6cd5\u786e\u5b9a\u54ea\u79cdBCG\u7ef4\u6301\u6cbb\u7597\u65b9\u6848\u8ba1\u5212\u6700\u6709\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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22.2.3   BCG\u8010\u836f\u673a\u5236<\/p>\n<\/section>\n

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\u7136\u800c\uff0c\u4f7f\u7528BCG\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670940-50%\u4ecd\u7136\u4f1a\u51fa\u73b0\u75be\u75c5\u8fdb\u5c55\u6216\u590d\u53d1\u3002\u90a3\u4e48\u95ee\u9898\u6765\u4e86\uff0c\u662f\u4ec0\u4e48\u5bfc\u81f4\u4e86BCG\u6cbb\u7597\u5bf9\u90e8\u5206NMIBC\u60a3\u8005\u65e0\u6548\u5462\uff1f\u4ee5\u4e0b\u63d0\u51fa\u4e86\u4e00\u4e9b\u5047\u8bbe\uff1a<\/p>\n

\u7b2c\u4e00\uff0c\u867d\u7136\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u5e7f\u6cdb\uff0c\u4f46\u80bf\u7624\u76f8\u5173\u6297\u539f\u7684\u7279\u5f02\u6027\u53ef\u80fd\u4e0d\u591f\u5f3a\u3002<\/p>\n

\u7b2c\u4e8c\uff0c\u867d\u7136\u5b58\u5728\u6297\u539f\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\uff0c\u4f46\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u5f53NK\u7ec6\u80de\u91ca\u653e\u9ad8\u6d53\u5ea6\u7684Th1\u7ec6\u80de\u56e0\u5b50\uff08\u5982IFN\u03b3\uff09\u65f6\uff0cPD-1\/PD-L1\u4e0a\u8c03\uff0c\u4ece\u800c\u635f\u5bb3\u4e86T\u7ec6\u80de\u7684\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n

\u80bf\u7624\u7ec6\u80dePD-L1\u8868\u8fbe\u7684\u589e\u52a0\u53ef\u4ee5\u9884\u6d4b\u5c40\u90e8\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u5206\u671f\u8fdb\u5c55\uff0c\u4e0e\u80bf\u7624\u5206\u7ea7\u65e0\u5173\u3002\u6b64\u5916\uff0cPD-L1\u5728\u539f\u4f4d\u764c\uff08CIS\uff09\u548cBCG\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u8180\u80f1\u8089\u82bd\u80bf\u5185\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\u3002\u5728BCG\u6cbb\u7597\u524d\uff0c\u7ea640%\u7684CIS\u80bf\u7624\u5b58\u5728PD-L1\uff0c\u4f46\u8fd9\u4e9b\u80bf\u7624\u7ec6\u80de\u7684PD-L1\u8868\u8fbe\u91cf\u76f8\u5bf9\u8f83\u4f4e\uff08\u7ea6\u5360\u80bf\u7624\u7ec6\u80de\u76845%\uff09\u3002<\/p>\n

\u76f8\u53cd\uff0c\u5728BCG\u6cbb\u7597\u6700\u7ec8\u5931\u8d25\u7684CIS\u75c5\u4f8b\u4e2d\uff0cPD-L1\u8868\u8fbe\u6c34\u5e73\u9ad8\u51fa15-20\u500d\uff0c\u4e14\u4e3b\u8981\u5b58\u5728\u4e8eBCG\u8089\u82bd\u80bf\u4e2d\u3002\u56e0\u6b64\uff0c\u8180\u80f1\u80bf\u7624\uff08\u5305\u62ecCIS\uff09\u8868\u8fbe\u7684PD-L1\u53ef\u80fd\u4e3a\u5c3f\u8def\u4e0a\u76ae\u80bf\u7624\u7ec6\u80de\u63d0\u4f9b\u4e00\u79cd\u7834\u574f\u5bbf\u4e3b\u6297\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u5e76\u63a8\u52a8\u6076\u6027\u80bf\u7624\u8fdb\u5c55\u7684\u5206\u5b50\u673a\u5236\u3002\u6b64\u5916\uff0cBCG\u6cbb\u7597\u540e\u88ab\u62db\u52df\u5230\u8180\u80f1\u7ec4\u7ec7\u4e2d\u7684\u5355\u6838\u7ec6\u80de\u5bf9T\u7ec6\u80de\u6291\u5236\u6027PD-L1\u7684\u8868\u8fbe\u589e\u52a0\u53ef\u80fd\u4f1a\u5bfc\u81f4\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0cBCG\u6cbb\u7597\u6548\u679c\u4e0b\u964d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4f7f\u7528\u8367\u5149\u7d20\u9176\u6807\u8bb0\u7684\u5c0f\u9f20\u8180\u80f1\u764c\u7ec6\u80deMB49(luc)\u8fdb\u884c\u7814\u7a76\u65f6\uff0c\u53d1\u73b0MB49(luc)\u8180\u80f1\u80bf\u7624\u7684PD-L1\u8868\u8fbe\u9ad8\u5ea6\u9633\u6027\uff0c\u5e76\u4e14\u963f\u7ef4\u5355\u6297\uff08avelumab\uff09\u8bf1\u5bfc\u4e86\u663e\u8457\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u8fd9\u4e9b\u6297\u80bf\u7624\u4f5c\u7528\u66f4\u4f9d\u8d56\u4e8eCD4+<\/sup>\u800c\u4e0d\u662fCD8+<\/sup> T\u7ec6\u80de\u7684\u5b58\u5728\uff0c\u4e14\u8fd9\u662f\u7531\u4f53\u5185\u514d\u75ab\u7ec6\u80de\u6d88\u8017\u7684\u6c34\u5e73\u51b3\u5b9a\u7684\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u8be5\u8180\u80f1\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u514d\u75ab\u6291\u5236PD-1\/PD-L1\u590d\u5408\u7269\u53ef\u6fc0\u6d3b\u5c40\u90e8\u9002\u5e94\u6027\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u51cf\u7f13\u80bf\u7624\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660ePD-L1\u7684\u5b58\u5728\u53ef\u80fd\u4e0e\u5bbf\u4e3b\u514d\u75ab\u76f8\u5173\u53cd\u5e94\u7684\u635f\u4f24\u53ca\u8180\u80f1\u764c\u7684\u8fdb\u5c55\u6709\u5173\u3002\u8fd9\u4e5f\u8868\u660ePD-1\/PD-L1\u76f8\u4e92\u4f5c\u7528\u5177\u6709\u6f5c\u5728\u7684\u751f\u7269\u5b66\u4f5c\u7528\uff0c\u53ef\u4ee5\u4f5c\u4e3aNMIBC\u65b0\u7684\u514d\u75ab\u6cbb\u7597\u9776\u70b9\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684\u51e0\u9879\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76PD-1\u6216PD-L1\u6291\u5236\u5242\u5728BCG\u96be\u6cbb\u6027NMIBC\u60a3\u8005\u53ca\u672a\u63a5\u53d7\u8fc7BCG\u6cbb\u7597\u7684\u9ad8\u5371NMIBC\u60a3\u8005\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

22.3  PD-1 \u548c PD-L1 \u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

22.3.1   PD-1 \u548c PD-L1 \u6291\u5236\u5242\u7684\u4f5c\u7528\u539f\u7406<\/p>\n<\/section>\n

\n
\n
\n

\u6b63\u5982\u4e0a\u8ff0\u6240\u8ff0\uff0cBCG\u6cbb\u7597NMIBC\u5df2\u7ecf\u4f7f\u7528\u4e86\u6570\u5341\u5e74\u3002\u9664\u4e86BCG\u7684\u4e34\u5e8a\u7597\u6548\u5916\uff0c\u5c3f\u9053\u764c\u7684\u751f\u7269\u7279\u5f81\u63d0\u793aPD-1\u548cPD-L1\u6291\u5236\u5242\u53ef\u80fd\u5bf9\u8180\u80f1\u764c\u6709\u6548\u3002\u9996\u5148\uff0c\u5df2\u7ecf\u8bc1\u5b9e\u65b0\u6297\u539f\u3001\u764c\u75c7\u7684\u514d\u75ab\u8c03\u8282\u548cPD-1\u8f74\u963b\u65ad\u7684\u4e34\u5e8a\u7597\u6548\u4e4b\u95f4\u5b58\u5728\u5173\u8054\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u548c\u80ba\u764c\u5728\u5185\u7684\u5404\u79cd\u7c7b\u578b\u7684\u764c\u75c7\u3002\u5728\u8fd9\u4e9b\u62a5\u9053\u4e2d\uff0c\u5177\u6709\u9ad8\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u548c\u9ad8\u65b0\u6297\u539f\u7684\u60a3\u8005\u66f4\u5bb9\u6613\u5bf9CTLA-4\u6291\u5236\u5242\u6216PD-1\/PD-L1\u6291\u5236\u5242\u4ea7\u751f\u53cd\u5e94\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\u514d\u75ab\u5fae\u73af\u5883\u4e2d\u7684\u603b\u4f53\u7a81\u53d8\u8d1f\u8377\u3001\u65b0\u6297\u539f\u8d1f\u8377\u548c\u7ec6\u80de\u6eb6\u89e3\u6807\u5fd7\u7269\u8868\u8fbe\u4e0e\u514d\u75ab\u7597\u6cd5\u7684\u4e34\u5e8a\u6548\u76ca\u663e\u8457\u76f8\u5173\u3002<\/p>\n

\u4e0e\u80ba\u764c\u4e00\u6837\uff0c\u5438\u70df\u5728\u8180\u80f1\u764c\u60a3\u8005\u4e2d\u4f1a\u8bf1\u53d1\u591a\u79cd\u86cb\u767d\u8d28\u6c34\u5e73\u7684\u9519\u8bef\uff0c\u5bfc\u81f4\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u51fa\u73b0\u5927\u91cf\u6076\u6027\u7684\u76f8\u5173\u65b0\u6297\u539f\u3002\u57fa\u56e0\u7ec4\u7814\u7a76\u8bc1\u5b9e\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\u5177\u6709\u9ad8\u5ea6\u7a81\u53d8\u7684\u7279\u70b9\uff0c\u6bcf\u5146\u78b1\u57fa\u7a81\u53d8\u4e2d\u4f4d\u6570\u4e3a8\u3002\u5f53\u5217\u51fa\u7a81\u53d8\u8d1f\u8377\u4ece\u9ad8\u5230\u4f4e\u7684\u764c\u75c7\u65f6\uff0c\u5c3f\u8def\u4e0a\u76ae\u764c\u6392\u540d\u7b2c\u4e09\uff0c\u7d27\u968f\u9ed1\u8272\u7d20\u7624\u548c\u80ba\u764c\u4e4b\u540e\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cPD-1\/PD-L1\u6291\u5236\u5242\u53ef\u80fd\u662f\u6cbb\u7597\u8180\u80f1\u764c\u7684\u6709\u6548\u65b9\u6cd5\u4e4b\u4e00\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5176\u6b21\uff0cPD-L1\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u6240\u6709\u9636\u6bb5\u90fd\u5f88\u5e38\u89c1\uff0c\u5e76\u4e14\u4e0eNMIBC\u548c\u808c\u5c42\u6d78\u6da6\u6027\u8180\u80f1\u80bf\u7624\uff08MIBC\uff09\u7684\u4e0d\u826f\u9884\u540e\u6709\u5173\u3002\u5728\u63a5\u53d7\u6839\u6cbb\u6027\u8180\u80f1\u5207\u9664\u672f\u7684\u975e\u8f6c\u79fb\u6027MIBC\u60a3\u8005\u4e2d\uff0c\u80bf\u7624\u7ec6\u80de\uff08TC\uff09PD-L1\u72b6\u6001\u4e0e\u665a\u671f\u75be\u75c5\u548c\u751f\u5b58\u7387\u4e0b\u964d\u6709\u5173\u3002\u4e00\u9879\u9488\u5bf9302\u540d\u60a3\u8005\u7684\u5927\u578b\u7814\u7a76\u63ed\u793a\u4e86PD-L1\u72b6\u6001\u4e0e\u8fdb\u884c\u4e86\u8180\u80f1\u5207\u9664\u672f\u7684\u5668\u5b98\u5c40\u9650\u6027\u75be\u75c5\u60a3\u8005\u7684\u6b7b\u4ea1\u98ce\u9669\u589e\u52a0\u4e4b\u95f4\u5b58\u5728\u76f8\u4f3c\u7684\u5173\u8054\u8d8b\u52bf\u3002<\/p>\n

\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u514d\u75ab\u7ec6\u80de(IC)PD-L1\u7684\u8868\u8fbe\u4e0e\u8f6c\u79fb\u6027\u94c2\u7c7b\u96be\u6cbb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u7684\u751f\u5b58\u6539\u5584\u6709\u5173\u3002\u53e6\u4e00\u9879\u7814\u7a76\u901a\u8fc7\u514d\u75ab\u7ec4\u5316(IHC)\u8bc1\u5b9e\u4e86PD-L1\u67d3\u8272\u4e0e\u987a\u94c2\u65b0\u8f85\u52a9\u5316\u7597\u7684\u7597\u6548\u5177\u6709\u76f8\u5173\u6027\u3002\u5bf9\u4e8e\u90a3\u4e9b\u5728\u65b0\u8f85\u52a9\u5316\u7597\u4e2d\u6ca1\u6709\u53cd\u5e94\u7684\u60a3\u8005\uff0c\u901a\u5e38\u5728\u80bf\u7624\u4e2d\u4f1a\u6709PD-L1\u7684\u8868\u8fbe(40%)\uff0c\u8fd9\u63d0\u793a\u8fd9\u4e9b\u60a3\u8005\u53ef\u80fd\u9002\u7528\u4e8e\u6297PD-L1\u7597\u6cd5\u3002<\/p>\n

\u603b\u4e4b\uff0c\u8fd9\u4e9b\u6570\u636e\u8868\u660ePD-L1\u5728\u80bf\u7624\u7ec6\u80de\u6216\u514d\u75ab\u7ec6\u80de\u4e0a\u7684\u8868\u8fbe\u4ee5\u53ca\u53ef\u4ee5\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u4e2d\u89c2\u5bdf\u5230\u7684\u9ad8\u7a81\u53d8\u8d1f\u8f7d\uff0c\u4e3a\u7814\u7a76\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5960\u5b9a\u4e86\u57fa\u7840\u3002\u8fd9\u4e00\u53d1\u73b0\u4e3a\u5f00\u53d1\u6cbb\u7597\u5c3f\u8def\u4e0a\u76ae\u764c\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u63d0\u4f9b\u4e86\u6307\u5bfc\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

22.3.2   PD-1 \u548c PD-L1 \u6291\u5236\u5242\u7684\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76<\/p>\n<\/section>\n

\n
\n
\n

\u57fa\u4e8e\u4e00\u98791\u671f\u6269\u5c55\u8bd5\u9a8c\u7684\u6570\u636e\uff0c\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08Atezolizumab\uff09\u5728\u6cbb\u7597\u5c3f\u8def\u4e0a\u76ae\u764c\u9886\u57df\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u8fdb\u5c55\uff0c\u8be5\u8bd5\u9a8c\u5bf9\u8c61\u4e3a68\u4f8b\u91cd\u5ea6\u9884\u5904\u7406\u7684\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u3002\u7814\u7a76\u5bf9\u514d\u75ab\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5b83\u4eec\u7684PD-L1\u514d\u75ab\u7ec4\u5316\u8bc4\u5206\u4e3a0\u30011\u30012\u30013\uff0c\u5206\u522b\u5bf9\u5e94\u67d3\u8272<1%\u30011-5%\u30015-10%\u548c>10%\u3002<\/p>\n

\u5728\u9884\u5148\u7b5b\u9009\u7684\u4eba\u7fa4\u4e2d\uff0c27%\u7684\u60a3\u8005\u7684\u80bf\u7624\u6d78\u6da6\u6027\u514d\u75ab\u7ec6\u80dePD-L1\u8868\u8fbe\u9633\u6027\uff08\u514d\u75ab\u7ec4\u5316\u8bc4\u5206\u4e3a2\u62163\uff09\u3002\u9996\u5148\uff0c\u5bf9\u6d78\u6da6\u6027\u80bf\u7624\u7684\u514d\u75ab\u7ec6\u80de\u8fdb\u884cPD-L1\u514d\u75ab\u7ec4\u5316\uff0c\u4ee5\u9a8c\u8bc1PD-L1\u9633\u6027\u60a3\u8005\u53ef\u80fd\u5bf9\u963f\u66ff\u5229\u73e0\u5355\u6297\u5177\u6709\u7279\u5f02\u6027\u53cd\u5e94\u7684\u5047\u8bbe\u3002\u968f\u540e\uff0c\u8be5\u8bd5\u9a8c\u6269\u5927\u5230\u6cbb\u7597\u65e0\u8bbaPD-L1\u72b6\u6001\u5982\u4f55\u7684\u60a3\u8005\uff0c\u4ee5\u786e\u5b9aPD-L1\u9634\u6027\u7684\u60a3\u8005\u662f\u5426\u4e5f\u4f1a\u6709\u53cd\u5e94\u3002\u603b\u5171\u7b5b\u67e5\u4e86205\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d23%\u7684\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80dePD-L1\u4e3a\u9633\u6027\uff0c4%\u7684\u60a3\u8005\u7684\u80bf\u7624\u7ec6\u80dePD-L1\u4e3a\u9633\u6027\u3002<\/p>\n

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\n
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\n

\u968f\u7740\u968f\u8bbf\u65f6\u95f4\u7684\u5ef6\u957f\uff0c\u5355\u836f\u963f\u66ff\u5229\u73e0\u5355\u6297\u5728\u672c1\u671f\u7814\u7a76\u7684\u91cd\u5ea6\u9884\u5904\u7406\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u89c2\u5bdf\u5230\u4e86\u5728\u5927\u91cf\u9884\u5904\u7406\u7684\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u4eba\u7fa4\u4e2d\u7684\u826f\u597d\u4e34\u5e8a\u6548\u76ca\u3002\u6240\u6709\u60a3\u8005\u76842\u5e74\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7387\u4e3a30%\uff0c\u800c\u514d\u75ab\u7ec4\u5316\u8bc4\u5206\u4e3a2\/3\u7684\u80bf\u7624\u60a3\u8005\u76842\u5e74\u603b\u751f\u5b58\u671f\u7387\u4e3a43%\uff0c\u5176\u5316\u7597\u53f2\u751f\u5b58\u7387\u9ad8\u4e8e\u65e2\u5f80\u751f\u5b58\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u5728310\u4f8b\u6cbb\u7597\u60a3\u8005\u4e2d\uff0c\u53ea\u67095%\u7684\u60a3\u8005\u51fa\u73b0\u4e863-4\u7ea7\u514d\u75ab\u4ecb\u5bfc\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5176\u4e2d\u80ba\u708e\u3001\u5929\u95e8\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u5347\u9ad8\u3001\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\u5347\u9ad8\u3001\u76ae\u75b9\u548c\u547c\u5438\u56f0\u96be\u662f\u6700\u5e38\u89c1\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u4e2d\u4f4d\u751f\u5b58\u671fOS\uff0850%\u7684\u60a3\u8005\u8fbe\u5230\u7684\u751f\u5b58\u65f6\u95f4\uff09\u4e3a15.9\u4e2a\u6708\uff0c\u8fdc\u597d\u4e8e\u8be5\u4eba\u7fa4\u63a5\u53d7\u5316\u7597\uff08\u7ea6\u4e3a9\u4e2a\u6708\uff09\u7684\u9884\u671fOS\u3002\u540c\u6837\uff0c\u8be5\u6cbb\u7597\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u53ea\u67098%\u7684\u60a3\u8005\u7ecf\u5386\u4e86\u5bfc\u81f4\u6cbb\u7597\u4e2d\u65ad\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c12%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u514d\u75ab\u4ecb\u5bfc\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

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\n
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\n

\u9664\u4e86\u963f\u66ff\u5229\u73e0\u5355\u6297\uff0c\u76ee\u524d\u8bb8\u591a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e5f\u5728\u7814\u7a76\u4e2d\uff0c\u5305\u62ecPD-1\u6291\u5236\u5242\u6d3e\u59c6\u5355\u6297\uff08pembrolizumab\uff09\u3001\u7eb3\u6b66\u5355\u6297\uff08nivolumab\uff09\u4ee5\u53caPD-L1\u6291\u5236\u5242\u5fb7\u74e6\u9c81\u5355\u6297\uff08durvalumab\uff09\u548c\u963f\u7ef4\u5355\u6297\uff08avelumab\uff09\u3002<\/p>\n

\u603b\u7684\u6765\u8bf4\uff0c\u57281\u671f\u548c2\u671f\u8bd5\u9a8c\u4e2d\uff0c\u8f6c\u79fb\u6027UC\u5316\u7597\u60a3\u8005\u7684\u603b\u4f53\u7f13\u89e3\u7387\u4e3a20-25%\uff0c\u65e9\u671f\u7f13\u89e3\uff08\u5728\u524d\u4e24\u4e2a\u6708\u5185\uff09\u548c\u6301\u4e45\u7f13\u89e3\uff08\u5728\u8bd5\u9a8c\u5206\u6790\u65f6\u901a\u5e38\u6ca1\u6709\u8fbe\u5230\uff09\u7684\u7ed3\u679c\u4e00\u81f4\uff08<\/span>Table 22.1)<\/span>\u3002\u6b64\u5916\uff0cPD-1\u548cPD-L1\u6291\u5236\u5242\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u6cbb\u7597\u76f8\u5173\u76843-4\u7ea7\u4e8b\u4ef6\u5f88\u5c11\uff08<15%\uff09\uff0c\u51e0\u4e4e\u6ca1\u6709\u6cbb\u7597\u76f8\u5173\u7684\u6b7b\u4ea1\u3002<\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u6570\u636e\u8d85\u8fc7\u4e86\u4e8c\u7ebf\u5316\u7597\u901a\u5e38\u89c2\u5bdf\u5230\u7684\u6570\u636e\uff0c\u4e8c\u7ebf\u5316\u7597\u7684\u5386\u53f2\u53cd\u5e94\u7387\u4e3a10%\u3002\u6b64\u5916\uff0c\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u5b89\u5168\u6027\u4e5f\u8f83\u597d\uff0c\u8fd9\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u5c06\u5176\u4f5c\u4e3a\u6cbb\u7597\u65e9\u671f\u6216\u8f6c\u79fb\u6027UC\u7684\u4e00\u79cd\u6709\u6548\u9009\u62e9\u7684\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Table 22.1<\/span> PD1\u6216PD-L\u6291\u5236\u5242\u5728\u8f6c\u79fb\u6027UC\u4e2d\u7684\u65e9\u671f1\/2\u671f\u7814\u7a76\u6570\u636e\u3002\u5176\u4e2dIC\u8868\u793a\u514d\u75ab\u7ec6\u80de\uff0cNA\u8868\u793a\u4e0d\u53ef\u7528\uff0cNR\u8868\u793a\u672a\u8fbe\u5230\uff0cORR\u4ee3\u8868\u603b\u5e94\u7b54\u7387\uff0cOS\u4ee3\u8868\u603b\u751f\u5b58\u7387\uff0cPD-1\u4ee3\u8868\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea11\uff0cPD-L1\u4ee3\u8868\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u914d\u4f531\uff0cTC\u4ee3\u8868\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Pernelle Lavaud and Yohann Loriot<\/span><\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u9648\u6653\u610f \u90ed\u5b50 \u7f57\u4f73\u4f73<\/span><\/span><\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u6797\u5b50\u7545<\/span><\/span><\/span><\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

22.1 \u4ecb\u7ecd \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u662f\u5f53\u524d\u5907\u53d7\u5173\u6ce8\u7684\u764c\u75c7\u7814\u7a76\u9886\u57df\u3002\u5b83\u5df2\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u663e\u793a\u51fa\u4e86\u6297\u80bf\u7624\u6d3b\u6027\u548c\u751f…<\/p>\n","protected":false},"author":1,"featured_media":3180,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3183"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3183"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3183\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3180"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3183"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}