{"id":3208,"date":"2023-08-15T11:18:16","date_gmt":"2023-08-15T03:18:16","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/08\/15\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac24%e7%ab%a0%ef%bc%9a%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%ef%bc%9at-vec%e5%92%8c%e5%85%b6%e4%bb%96%ef%bc%88%e4%b8%8b%ef%bc%89\/"},"modified":"2023-08-15T11:18:16","modified_gmt":"2023-08-15T03:18:16","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac24%e7%ab%a0%ef%bc%9a%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%ef%bc%9at-vec%e5%92%8c%e5%85%b6%e4%bb%96%ef%bc%88%e4%b8%8b%ef%bc%89","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/08\/15\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac24%e7%ab%a0%ef%bc%9a%e6%ba%b6%e7%98%a4%e7%97%85%e6%af%92%ef%bc%9at-vec%e5%92%8c%e5%85%b6%e4%bb%96%ef%bc%88%e4%b8%8b%ef%bc%89\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c24\u7ae0\uff1a\u6eb6\u7624\u75c5\u6bd2\uff1aT-VEC\u548c\u5176\u4ed6\uff08\u4e0b\uff09"},"content":{"rendered":"
\n
\n
\n

\u4e0a\u671f\u5185\u5bb9\uff1a<\/strong><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c24\u7ae0\uff1a\u6eb6\u7624\u75c5\u6bd2\uff1aT-VEC\u548c\u5176\u4ed6\uff08\u4e0a\uff09<\/a><\/p>\n<\/section>\n

\n


<\/p>\n<\/section>\n

\n

24.2.6 \u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/p>\n<\/section>\n

\n
\n
\n

\u5728\u5bf9436\u540d\u4e0d\u80fd\u5207\u9664\u7684IIIB-IV\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u8fdb\u884c\u7684\u968f\u673aIII\u671fOPTIM\u8bd5\u9a8c\u4e2d\uff0c\u6bd4\u8f83\u4e86\u7624\u5185\u6ce8\u5c04T-VEC\u548cGM-CSF\u7684\u7597\u6548\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u6301\u4e45\u53cd\u5e94\u7387\uff08DRR\uff09\uff0c\u5176\u5b9a\u4e49\u662f\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u6807\u51c6\u8bc4\u4f30\u7684\u3001\u5728\u5f00\u59cb\u6cbb\u7597\u7684\u524d12\u4e2a\u6708\u5185\u6301\u7eed\u22656\u4e2a\u6708\u7684\u53cd\u5e94\u3002T-VEC\u7ec4\u7684DRR\u660e\u663e\u4f18\u4e8eGM-CSF\u7ec4(16.3%\u6bd42.1%\uff1bp<0.001)\u3002\u4e0eGM-CSF\u7ec4\u76f8\u6bd4\uff0cT-VEC\u7ec4\u7684\u603b\u4f53\u53cd\u5e94\u7387(ORR)\u4e5f\u66f4\u9ad8(26.4% vs 5.7%)\uff0c T-VEC\u7ec4\u7684\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\uff09\u4e3a10.8%\u3002T-VEC\u7ec4\u7684\u603b\u751f\u5b58\u671f(OS)\u6709\u6539\u5584\u7684\u8d8b\u52bf\uff0c\u4e2d\u4f4dOS\u4e3a23.3\u4e2a\u6708\uff0c\u800cGM-CSF\u7ec4\u4e3a18.9\u4e2a\u6708\u3002\u63a2\u7d22\u6027\u5206\u6790\u8868\u660e\uff0cT-VEC \u5bf9\u65e9\u671f\u75be\u75c5\uff08IIIB\u3001IIIC \u6216 IVM1a \u671f\uff09\u60a3\u8005\u548c\u5bf9\u6cbb\u7597\u4e0d\u654f\u611f\u7684\u60a3\u8005\u7684 DRR \u548c OS \u7684\u5f71\u54cd\u66f4\u4e3a\u660e\u663e\uff08Fig. 24.4<\/span>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 24.4<\/span> Kaplan-Meier\u66f2\u7ebf\u63cf\u7ed8\u4e86\u5728III\u671fOPTIM\u8bd5\u9a8c\u4e2d\u60a3\u6709IIIB\u3001IIIC\u548cIV A\u671f\u75be\u75c5\u7684\u60a3\u8005\u7684\u603b\u5b58\u6d3b\u7387<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

Andtbacka \u7b49\u4eba\u5728\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\u62a5\u544a\u4e86 OPTiM \u7814\u7a76\u4e2d\u4f7f\u7528 T-VEC \u7684\u53cd\u5e94\u6a21\u5f0f\uff0c\u6307\u51fa\u5373\u4f7f\u5728\u672a\u6ce8\u5c04\u7684\u975e\u5185\u810f\u548c\u5185\u810f\u75c5\u53d8\u4e2d\uff0c\u53cd\u5e94\u7387\u4e5f\u76f8\u5f53\u53ef\u89c2\u3002\u6ce8\u5c04\u75c5\u7076\u3001\u672a\u6ce8\u5c04\u7684\u975e\u5185\u810f\u75c5\u7076\u548c\u5185\u810f\u75c5\u7076\u7684 ORR \u5206\u522b\u4e3a 32%\u300118% \u548c 14%\uff0c\u76f8\u5e94\u7684 CR \u7387\u5206\u522b\u4e3a 15%\u30016% \u548c 3%\u3002\u6ce8\u5c04\u75c5\u7076\u7684\u53cd\u5e94\u65f6\u95f4\u8f83\u77ed\uff0c\u7ea6\u4e3a9.3\u5468\uff0c\u800c\u672a\u6ce8\u5c04\u90e8\u4f4d\u7684\u53cd\u5e94\u65f6\u95f4\u4e3a12.3-12.9\u5468\u300216%\u63a5\u53d7T-VEC\u6cbb\u7597\u7684\u60a3\u8005\u6709\u6301\u4e45\u7684\u53cd\u5e94\u3002\u53cd\u5e94\u524d\u8fdb\u5c55\uff08PPR\uff09\u4e0d\u662f\u9884\u6d4bDR\u6301\u7eed\u65f6\u95f4\u6216OS\u7684\u6307\u6807\u3002\u7136\u800c\uff0c\u8fd1 50% \u7684 T-VEC \u6301\u4e45\u5e94\u7b54\u8005\u51fa\u73b0\u4e86 PPR\uff0c\u4e3b\u8981\u662f\u7531\u4e8e\u51fa\u73b0\u4e86\u65b0\u7684\u75c5\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.2.7 \u4e0d\u826f\u4e8b\u4ef6<\/p>\n<\/section>\n

\n
\n
\n

T-VEC\u7ed9\u836f\u901a\u5e38\u53ea\u4f1a\u51fa\u73b0\u8f7b\u5fae\u4e0d\u826f\u4e8b\u4ef6\u3002\u5728Hu\u7b49\u4eba\u7684I\u671f\u8bd5\u9a8c\u4e2d\uff0c\u6ce8\u610f\u5230\u7684\u4e3b\u8981\u526f\u4f5c\u7528\u662f1\/2\u7ea7\u53d1\u70ed\uff0c\u8fd9\u5728HSV\u8840\u6e05\u9634\u6027\u7684\u60a3\u8005\u4e2d\u66f4\u4e3a\u660e\u663e\u3002\u5176\u4ed6\u4e00\u4e9b\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u662f\u75b2\u52b3\u3001\u6076\u5fc3\u3001\u5455\u5410\u548c\u538c\u98df\u3002\u5728\u7b2c\u4e8c\u9636\u6bb5\u7814\u7a76\u4e2d\uff0c85%\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7ecf\u5386\u4e86\u6700\u5e38\u89c1\u76841\/2\u7ea7\u6d41\u611f\u6837\u75c7\u72b6\u7684\u4e0d\u826f\u4e8b\u4ef6\u30023 \u540d\u6709\u53cd\u5e94\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u767d\u765c\u98ce\uff0c\u8fd9\u662f\u5176\u4ed6\u514d\u75ab\u7597\u6cd5\uff08\u5982 IL-2\uff09\u7684\u5e38\u89c1\u75c7\u72b6\u3002\u5728 III \u671f OPTiM \u7814\u7a76\u4e2d\uff0cT-VEC\u5728\u7814\u7a76\u4eba\u7fa4\u4e2d\u603b\u4f53\u8010\u53d7\u6027\u826f\u597d\uff0c\u62a5\u544a\u7684\u5e38\u89c1\u4e0d\u826f\u4e8b\u4ef6(AEs)\u5305\u62ec\u75b2\u52b3\u3001\u5bd2\u6218\u548c\u53d1\u70e7\u30023\/4\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u975e\u5e38\u7f55\u89c1\uff0c\u552f\u4e00\u62a5\u544a\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u8702\u7a9d\u7ec4\u7ec7\u708e\uff0cT-VEC \u7ec4\u7684\u53d7\u8bd5\u8005\u4e2d\u4ec5\u6709 2% \u4ee5\u4e0a\u51fa\u73b0\u8fd9\u79cd\u4e0d\u826f\u53cd\u5e94\u3002\u5bf9\u4e59\u9170\u6c28\u57fa\u915a\u6216\u5432\u54da\u7f8e\u8f9b\u53ef\u7528\u4e8e\u9884\u9632\u6216\u6cbb\u7597 T-VEC \u6cbb\u7597\u540e\u5f15\u8d77\u7684\u75bc\u75db\u3001\u53d1\u70ed\u6216\u5bd2\u6218\u3002\u7532\u54cc\u5576\u53ef\u7528\u4e8e\u63a7\u5236\u75c9\u631b\u3002\u80be\u4e0a\u817a\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\u6216\u6bcf\u5929\u670d\u7528\u6cfc\u5c3c\u677e 10 \u6beb\u514b\u6216\u66f4\u5c11\u5242\u91cf\u7684\u80be\u4e0a\u817a\u529f\u80fd\u51cf\u9000\u75c7\u60a3\u8005\u53ef\u4ee5\u63a5\u53d7 T-VEC \u6cbb\u7597\u3002\u5982\u679c\u6ce8\u5c04\u540e\u51fa\u73b0\u53d1\u70ed\u6216\u6d41\u611f\u6837\u75c7\u72b6\u7b49\u4e0d\u826f\u53cd\u5e94\uff0c\u53ef\u589e\u52a0\u76ae\u8d28\u7c7b\u56fa\u9187\u7684\u5242\u91cf\u3002\u8702\u7a9d\u7ec4\u7ec7\u708e\u662fT-VEC\u7ed9\u836f\u7684\u5df2\u77e5\u4e0d\u826f\u4e8b\u4ef6\u3002\u75b1\u75b9\u8702\u7a9d\u7ec7\u708e\u901a\u5e38\u662f\u81ea\u9650\u6027\u7684\uff0c\u6700\u957f\u572848\u5c0f\u65f6\u5185\u6e05\u9664\u3002\u5982\u679c\u51fa\u73b0\u53d1\u70ed\u548c\u767d\u7ec6\u80de\u589e\u591a\uff0c\u5fc5\u987b\u8003\u8651\u53e0\u52a0\u7ec6\u83cc\u611f\u67d3\u3002\u5982\u679c\u6000\u7591\u6709\u8111\u708e\u6216\u75c5\u6bd2\u8840\u75c7\uff0c\u4ece\u8840\u6db2\u548c\u8111\u810a\u6db2\u4e2d\u68c0\u6d4bHSV DNA\u7684PCR\u68c0\u6d4b\u662f\u53ef\u9760\u7684\u3002\u5982\u679c\u610f\u5916\u63a5\u89e6T-VEC\uff0c\u53ef\u8003\u8651\u4f7f\u7528\u963f\u6614\u6d1b\u97e6\u6216\u7c7b\u4f3c\u7684\u6297\u75c5\u6bd2\u836f\u7269\u3002\u5c3d\u7ba1\u7406\u8bba\u4e0a\u4ecd\u7136\u62c5\u5fc3\u75c5\u6bd2\u53ef\u80fd\u53d8\u5f02\u5e76\u91cd\u65b0\u83b7\u5f97\u81f4\u75c5\u6027\uff0c\u4f46\u8fd9\u5c1a\u672a\u5728\u4e34\u5e8a\u4e0a\u89c2\u5bdf\u5230\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6839\u636e\u4e00\u4e9b\u7814\u7a76\uff0cT-VEC\u4e0d\u5e94\u7528\u4e8e\u6d3b\u52a8\u6027\u75b1\u75b9\u611f\u67d3\u60a3\u8005\u6216\u6bcf\u65e5\u670d\u7528\u963f\u6614\u6d1b\u97e6\u7b49\u6297\u75c5\u6bd2\u836f\u7269\u7684\u60a3\u8005\u3002\u9274\u4e8eT-VEC\u662f\u4e00\u79cd\u6539\u826f\u7684\u51cf\u6bd2\u6d3b\u75c5\u6bd2\uff0c\u4e0d\u63a8\u8350\u7528\u4e8e\u514d\u75ab\u72b6\u6001\u4e25\u91cd\u53d7\u635f\u7684\u60a3\u8005\uff0c\u5982\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u611f\u67d3\u3001\u767d\u8840\u75c5\u6216\u6dcb\u5df4\u7624\u60a3\u8005\u6216\u63a5\u53d7\u9ad8\u5242\u91cf\u514d\u75ab\u6291\u5236\u6cbb\u7597\u7684\u60a3\u8005\u3002\u6ca1\u6709\u8db3\u591f\u7684\u8bc1\u636e\u6765\u786e\u5b9aT-VEC\u5728\u5b55\u5987\u6216\u513f\u7ae5\u4e2d\u7684\u5b89\u5168\u6027\uff0c\u56e0\u6b64\u4e0d\u63a8\u8350\u5728\u8fd9\u4e00\u4eba\u7fa4\u4e2d\u4f7f\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.2.8 \u7ecf\u6279\u51c6\u7684\u7528\u9014<\/p>\n<\/section>\n

\n
\n
\n

T-VEC\u662f\u9996\u4e2a\u7ecf\u7f8e\u56fd\u8054\u90a6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u6eb6\u7624\u75c5\u6bd2\uff0c\u7528\u4e8e\u6cbb\u7597\u521d\u6b21\u624b\u672f\u540e\u51fa\u73b0\u76ae\u80a4\u3001\u76ae\u4e0b\u548c\u6dcb\u5df4\u7ed3\u75c5\u53d8\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002\u8fd9\u4e00\u6279\u51c6\u662f\u57282015\u5e7410\u6708\u5ba3\u5e03\u7684\u3002\u6b64\u540e\u4e0d\u4e45\uff0c\u53732015\u5e7412\u6708\uff0c\u6b27\u6d32\u533b\u7597\u673a\u6784\uff08EMA\uff09\u6279\u51c6\u5176\u5728\u6b27\u6d32\u4f7f\u7528\u3002T-VEC\u4e8e2016\u5e745\u6708\u83b7\u5f97\u6fb3\u5927\u5229\u4e9a\u6cbb\u7597\u5546\u54c1\u7ba1\u7406\u5c40(TGA)\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3002\u5728\u6b27\u6d32\u548c\u6fb3\u5927\u5229\u4e9a\u83b7\u5f97\u6279\u51c6\u4ec5\u9650\u4e8e\u60a3\u6709\u65e0\u6cd5\u5207\u9664\u7684III\u671f\u6216IVa\u671f\u75be\u75c5\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u5176\u4f9d\u636e\u662f OPTiM \u7814\u7a76\u4e2d\u53d1\u73b0\u7684\u8fd9\u90e8\u5206\u4eba\u7fa4\u7684\u5353\u8d8a\u53cd\u5e94\u7387 \u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

BioVex\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6700\u521d\u4ee5OncoVEXGM CSF\u7684\u540d\u4e49\u5f00\u53d1\u4e86T-VEC\u3002\u57282011\u5e74\u88ab\u5b89\u8fdb(Amgen)\u6536\u8d2d\u540e\uff0c\u5b83\u73b0\u5728\u4ee5Imlygic\u7684\u540d\u79f0\u751f\u4ea7\u548c\u9500\u552e\u3002\u5176\u4f7f\u7528\u7684\u4e24\u5927\u5c40\u9650\u6027\u662f(1)\u4e0d\u80fd\u63d0\u9ad8\u603b\u4f53\u5b58\u6d3b\u7387\u548c(2)\u5bf9\u5185\u810f\u8f6c\u79fb\u6ca1\u6709\u5f71\u54cd\u3002\u76ee\u524d\uff0c\u8fd8\u6ca1\u6709\u660e\u786e\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4ee5\u5e2e\u52a9\u4e34\u5e8a\u533b\u751f\u9009\u62e9\u9002\u5408T-VEC\u6cbb\u7597\u7684\u60a3\u8005\u3002T-VEC\u6cbb\u7597\u7684\u60a3\u8005\u9009\u62e9\u7684\u4e00\u4e9b\u5efa\u8bae\u6807\u51c6\u662f\u53ef\u89e6\u53ca\u75be\u75c5\u7684\u60a3\u8005\uff1b\u5185\u810f\u75be\u75c5\u8d1f\u62c5\u8f83\u8f7b\uff0c\u53ef\u5148\u63a5\u53d7 T-VEC \u6cbb\u7597\u4ee5\u63a7\u5236\u5c40\u90e8\u75be\u75c5\uff0c\u7136\u540e\u518d\u63a5\u53d7\u68c0\u67e5\u70b9\u963b\u65ad\u5242\u7b49\u5168\u8eab\u6cbb\u7597\u7684\u60a3\u8005\uff1b\u8001\u5e74\u4eba\u6216\u60a3\u6709\u4e25\u91cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6216\u5176\u4ed6\u5408\u5e76\u75c7\u4e14\u4e0d\u9002\u5408\u63a5\u53d7\u5176\u4ed6\u5f62\u5f0f\u6cbb\u7597\u7684\u60a3\u8005\uff1b\u4ee5\u53ca\u7ecf\u8fc7\u5176\u4ed6\u6cbb\u7597\u65b9\u6cd5\u540e\u75c5\u60c5\u4ecd\u5728\u8fdb\u5c55\u7684\u60a3\u8005\u3002\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.2.9 T-VEC\u7684\u672a\u6765<\/p>\n<\/section>\n

\n
\n
\n

\u5c3d\u7ba1T-VEC\u5bf9\u5c40\u90e8\u75be\u75c5\u63a7\u5236\u6709\u663e\u8457\u4f5c\u7528\uff0c\u4f46\u5168\u8eab\u4f5c\u7528\u8f83\u5f31\uff0c\u8fd9\u4e3a\u8054\u5408\u6cbb\u7597\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\u3002\u4e0e\u5176\u4ed6\u514d\u75ab\u7597\u6cd5\u7c7b\u4f3c\uff0c\u4f7f\u7528\u4f20\u7edf\u7684\u80bf\u7624\u53cd\u5e94\u8bc4\u4f30\u65b9\u6cd5\uff0c\u5982RECIST\u548cWHO\uff0c\u800c\u4f20\u7edf\u7684\u80bf\u7624\u53cd\u5e94\u8bc4\u4f30\u65b9\u6cd5\u533a\u5206\u771f\u5b9e\u8fdb\u5c55\u548c\u5047\u6027\u8fdb\u5c55\u662f\u5177\u6709\u6311\u6218\u6027\u7684\u3002\u76ee\u524d\uff0c\u514d\u75ab\u80bf\u7624\u5b66\u754c\u5e7f\u6cdb\u8ba8\u8bba\u540e\u5f97\u51fa\uff0c\u5728\u8bc4\u4f30\u514d\u75ab\u7597\u6cd5\u7684\u5e94\u7b54\u65f6\uff0c\u5e94\u7279\u522b\u4f7f\u7528\u57fa\u4e8e\u514d\u75ab\u7684\u5e94\u7b54\u6807\u51c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u540c\u65f6\uff0c\u6211\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u6765\u786e\u5b9aT-VEC\u4e0e\u5176\u4ed6\u514d\u75ab\u6cbb\u7597\u836f\u7269\u7684\u9002\u5f53\u7ed3\u5408\u3002\u6b64\u5916\uff0c\u4ece\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u5c06\u5728\u672a\u6765\u83b7\u5f97\u66f4\u591a\u5173\u4e8eT-VEC\u6cbb\u7597\u987a\u5e8f\u7684\u4fe1\u606f\u3002T-VEC\u7684\u5927\u90e8\u5206\u6210\u529f\u6848\u4f8b\u90fd\u662f\u901a\u8fc7\u5c40\u90e8\u6ce8\u5c04\u83b7\u5f97\u7684\u3002\u6709\u5fc5\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u5176\u4ed6\u7ed9\u836f\u65b9\u6cd5\uff0c\u4ee5\u63a2\u7d22\u5176\u5bf9\u975e\u76ae\u80a4\u6076\u6027\u80bf\u7624\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

24.3 <\/strong>\u5176\u4ed6\u6eb6\u7624\u75c5\u6bd2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.1 \u547c\u80a0\u5b64\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

Pelareorep\uff08REOLYSIN\u00ae\uff09\u662f\u4e00\u79cd\u6d3b\u76843\u578b\u547c\u80a0\u5b64\u75c5\u6bd2\uff08T3D\uff09\u682a\uff0c\u80fd\u591f\u901a\u8fc7\u6fc0\u6d3b\u7684Ras\u9014\u5f84\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u590d\u5236\u3002\u86cb\u767d\u6fc0\u9176R\uff08PKR\uff09\u662f\u4e00\u79cd\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176\uff0c\u53c2\u4e0e\u62b5\u5fa1\u75c5\u6bd2\u611f\u67d3\uff0c\u5728Ras\u8f6c\u5316\u7ec6\u80de\u4e2d\u4e0d\u88ab\u6fc0\u6d3b\/\u78f7\u9178\u5316\u3002\u7531\u4e8e\u8bb8\u591a\u80bf\u7624\u542b\u6709\u6fc0\u6d3b\u7684Ras\u9014\u5f84\uff0c\u800cPKR\u5904\u4e8e\u5931\u6d3b\u6216\u975e\u78f7\u9178\u5316\u72b6\u6001\uff0c\u56e0\u6b64\u547c\u80a0\u5b64\u75c5\u6bd2\u6eb6\u7624\u7597\u6cd5\u53ef\u7528\u4e8e\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u590d\u53d1\u6027\u6076\u6027\u80f6\u8d28\u7624\u60a3\u8005\u7624\u5185\u6ce8\u5c04\u547c\u80a0\u5b64\u75c5\u6bd2\u7684I\u671f\u7814\u7a76\uff08REO 003\uff09\u4e2d\uff0c\u672a\u53d1\u73b0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u572811\u540d\u53ef\u8bc4\u4f30\u75be\u75c5\u60a3\u8005\u4e2d\uff0c10\u540d\u60a3\u8005\u75c5\u60c5\u8fdb\u5c55\uff0c1\u540d\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\u3002\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a21\u5468\uff0c\u4e2d\u4f4d\u8fdb\u5c55\u65f6\u95f4\u4e3a4.3\u5468\u3002\u5728\u4e00\u9879IIb\u671f\u8bd5\u9a8c\uff08GOG 186H\uff09\u4e2d\uff0c\u6bd4\u8f83\u4e86\u590d\u53d1\u6027\u6216\u6301\u7eed\u6027\u5375\u5de2\u764c\u3001\u8f93\u5375\u7ba1\u764c\u6216\u8179\u819c\u764c\u60a3\u8005\u4e2dREOLYSIN\u00ae\u52a0\u7d2b\u6749\u9187\u4e0e\u5355\u72ec\u4f7f\u7528\u7d2b\u6749\u9187\u7684\u60c5\u51b5\uff0c\u4e24\u7ec4\u60a3\u8005\u7684\u603b\u4f53\u751f\u5b58\u7387\u6ca1\u6709\u5dee\u5f02\uff0c\u4e24\u7ec4\u7684\u6bd2\u6027\u7279\u5f81\u76f8\u4f3c\u3002\u5728\u4e00\u9879\u9488\u5bf9NSCLC(\u9cde\u72b6\u548c\u817a\u764c\u7ec4\u7ec7\u5b66)\u7684\u968f\u673aII\u671f\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7\u591a\u897f\u7d2b\u6749\u9187\u6216\u57f9\u7f8e\u66f2\u585e\u8054\u5408REOLYSIN\u00ae\u6cbb\u7597\u7684\u5973\u6027\u817a\u764c\u60a3\u8005\u7684PFS\u660e\u663e\u4f18\u4e8e\u5355\u72ec\u4f7f\u7528\u57f9\u7f8e\u66f2\u585e\u7684\u5973\u6027\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

REOLYSIN\u00ae\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u5bf9\u6076\u6027\u80f6\u8d28\u7624\u3001\u80f0\u817a\u764c\u3001\u8179\u819c\u764c\u3001\u5375\u5de2\u764c\u548c\u8f93\u5375\u7ba1\u764c\u7684\u7f55\u7528\u836f\u6307\u5b9a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.2 \u67ef\u8428\u5947\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

\u67ef\u8428\u5947A21\u75c5\u6bd2\uff0c\u4e5f\u88ab\u79f0\u4e3aCA-V-A-TAK\uff0c\u662f\u4e00\u79cd\u81ea\u7136\u4ea7\u751f\u7684\u5fae\u5c0f\u6838\u7cd6\u6838\u9178\u75c5\u6bd2\uff0c\u5df2\u88ab\u8bc1\u660e\u4f1a\u5bfc\u81f4\u4eba\u7c7b\u8f7b\u5ea6\u547c\u5438\u9053\u75be\u75c5\u3002\u5b83\u5df2\u88ab\u8bc1\u660e\uff0c\u9664\u4e86\u524d\u5217\u817a\u764c\u3001\u4e73\u817a\u764c\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7b49\u5176\u4ed6\u7c7b\u578b\u7684\u80bf\u7624\u5916\uff0c\u5b83\u8fd8\u4f18\u5148\u611f\u67d3\u9ed1\u8272\u7d20\u7624\u4e2d\u5e38\u89c1\u7684ICAM-1\u8868\u8fbe\u7ec6\u80de\u3002\u5b83\u662f\u4e00\u79cd\u57fa\u56e0\u4e0a\u672a\u7ecf\u4fee\u9970\u7684\u75c5\u6bd2\uff0c\u6839\u636e\u4e0d\u53ef\u5207\u9664\u7684III\/IV\u671f\u9ed1\u8272\u7d20\u7624\u8fdb\u884c\u7684II\u671fCALM\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\uff0c\u663e\u793a\u6709\u8f83\u597d\u7684\u7684\u7f13\u89e3\u7387\u3002irRC\u8bc4\u4f30\u7684\u6700\u4f73\u603b\u4f53\u7f13\u89e3\u7387\u4e3a28%\uff088\u4e2a\u5b8c\u5168\u7f13\u89e3\uff0c8\u4e2a\u90e8\u5206\u7f13\u89e3\uff09\u30026\u4e2a\u6708\u65f6\u7684irPFS\u7387\u4e3a39%\uff0c\u6301\u4e45\u7f13\u89e3\u7387\u4e3a21%\u300212\u4e2a\u6708OS\u7387\u4e3a73%\u3002\u5728\u6ce8\u5c04\u90e8\u4f4d\u548c\u975e\u6ce8\u5c04\u90e8\u4f4d\uff08\u5305\u62ec\u6dcb\u5df4\u7ed3\u3001\u80ba\u548c\u5176\u4ed6\u8fdc\u5904\u90e8\u4f4d\uff09\u5747\u89c2\u5bdf\u5230\u6d3b\u6027\u3002\u53e6\u4e00\u9879CVA21\u4e0epembrolizumab\u8054\u5408\u7684I\u671f\u8bd5\u9a8c\u8ba1\u5212\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u79cd\u4ecd\u5728\u8fdb\u884c\u4e34\u5e8a\u524d\u6d4b\u8bd5\u7684\u67ef\u8428\u5947\u75c5\u6bd2\u5df2\u663e\u793a\u51fa\u6cbb\u7597\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c(NSCLC)\u7684\u5e0c\u671b\u3002\u67ef\u8428\u5947\u75c5\u6bd2B3\uff08CVB3\uff09\u5bf9NSCLC\u7ec6\u80de\u7cfb\u663e\u793a\u51fa\u9009\u62e9\u6027\u503e\u5411\uff0c\u5e76\u663e\u793a\u51fa\u5f3a\u6548\u6027\u3002\u8fd9\u4e0e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u67ef\u8428\u5947\u548c\u817a\u75c5\u6bd2\u53d7\u4f53\uff08CARs\uff09\u7684\u8868\u8fbe\u76f8\u5173\u3002\u5409\u975e\u66ff\u5c3c\u5bf9\u653e\u5c04\u62b5\u6297\u548cEGFR\u963b\u65ad\u7684A549\u817a\u764c\u79fb\u690d\u7624\u6709\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.3 \u817a\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

Onyx-015\u662f\u901a\u8fc7\u5220\u9664\u817a\u75c5\u6bd2\u4e2d\u7684E1B\u57fa\u56e0\u6765\u6539\u9020\u7684\uff0c\u4ee5\u9009\u62e9\u6027\u5730\u590d\u5236\u548c\u6467\u6bc1p53\u7f3a\u5931\u7684\u80bf\u7624\u7ec6\u80de\u3002\u8fd9\u5728\u5355\u72ec\u6216\u4e0e\u5316\u7597\u8054\u5408\u6cbb\u7597\u590d\u53d1\u6027\/\u96be\u6cbb\u6027\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u65b9\u9762\u5df2\u663e\u793a\u51fa\u7597\u6548\u3002\u5b83\u5728\u4e2d\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5934\u9888\u764c\uff0c\u540d\u79f0\u4e3aH101\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

Delta-24-RGD(DNX-2401)\u662f\u4e00\u79cd\u9488\u5bf9\u80bf\u7624\u7ec6\u80de\u9009\u62e9\u6027\u9776\u5411\u6574\u5408\u7d20\u7684\u817a\u75c5\u6bd2\u3002\u5728\u4e34\u5e8a\u524d\uff0c\u5b83\u5df2\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u5de8\u5927\u7684\u524d\u666f\u3002\u76ee\u524d\uff0c\u6709\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u6d4b\u8bd5DNX-2401\u548cpembrolizumab\u8054\u5408\u6cbb\u7597\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3002\u4e00\u79cd\u8868\u8fbe\u4ebaGM-CSF\u7684\u5d4c\u5408\u817a\u75c5\u6bd2(Ad5\/3-D24-GMCSF)\u5df2\u7ecf\u572821\u4f8b\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86I\u671f\u8bd5\u9a8c\u3002\u6839\u636eRECIST\u6807\u51c6\u8bc4\u4f30\uff0c67%\u7684\u60a3\u8005\u83b7\u5f97\u4e86\u5ba2\u89c2\u7684\u4e34\u5e8a\u76ca\u5904\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8be5\u836f\u7269\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e3b\u8981\u4e3a1\/2\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e00\u9879Ad5\/3-D24-GMCSF\u4e0e\u4f4e\u5242\u91cf\u6301\u7eed\u73af\u78f7\u9170\u80fa\u8054\u5408\u7684I\/II\u671f\u7814\u7a76\u3002\u53e6\u5916\u8fd8\u6709\u4e00\u9879I\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\uff0c\u8be5\u8bd5\u9a8c\u4f7f\u7528\u8868\u8fbeL523S\u86cb\u767d\u7684\u91cd\u7ec4DNA\u548c\u817a\u75c5\u6bd2\u6cbb\u7597\u65e9\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.4 \u75d8\u82d7\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

Pexastimogene deval iepvec(PexA-V EC\u6216JX-594)\u662f\u4e00\u79cd\u57fa\u56e0\u5de5\u7a0b\u7684\u725b\u75d8\u75c5\u6bd2\u60e0\u6c0f\u682a\uff0c\u8868\u8fbeGM-CSF\uff0c\u4f46\u4e5f\u6709\u80f8\u82f7\u6fc0\u9176\u57fa\u56e0\u7684\u7f3a\u5931\uff0c\u8fd9\u6709\u52a9\u4e8e\u8be5\u75c5\u6bd2\u5728\u80f8\u82f7\u6fc0\u9176\u6c34\u5e73\u9ad8\u7684\u7ec6\u80de\u4e2d\u9009\u62e9\u6027\u590d\u5236\uff0c\u5c31\u50cf\u5728ras\u6216p53\u57fa\u56e0\u6539\u53d8\u7684\u80bf\u7624\u7ec6\u80de\u4e2d\u770b\u5230\u7684\u90a3\u6837\u3002\u5728PexA-V EC\u548c\u7d22\u62c9\u975e\u5c3c\u8054\u5408\u6cbb\u7597\u7684\u665a\u671f\u809d\u764c\u7684II\u671f\u7814\u7a76\u4e2d\uff0c\u5355\u72ec\u4f7f\u7528PexA-V EC\u7684\u75be\u75c5\u63a7\u5236\u7387\u4e3a62%\uff0c\u542f\u52a8\u7d22\u62c9\u975e\u5c3c\u540e\u7684\u75be\u75c5\u63a7\u5236\u7387\u4e3a59%\u3002\u89c2\u5bdf\u5230\u6682\u65f6\u60273\/4\u7ea7\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8be5\u65b9\u6848\u8010\u53d7\u6027\u826f\u597d\uff0c\u4ec5\u51fa\u73b0\u4e86\u7c7b\u4f3c\u6d41\u611f\u7684\u75c7\u72b6\u3001\u6076\u5fc3\u548c\u8179\u75db\u3002 <\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u53e6\u4e00\u9879\u6cbb\u7597\u96be\u6cbb\u6027\u7ed3\u76f4\u80a0\u764c\u7684Ib\u671f\u7814\u7a76\u4e2d\uff0c\u9759\u8109\u6ce8\u5c04Pexa Vec\u53ef\u8fbe\u523067%\u7684\u7a33\u5b9a\u53d1\u75c5\u7387\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u4e3a1\/2\u7ea7\u53d1\u70ed\u548c\u5bd2\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

PROSTVAC\u00ae\u662f\u4e00\u79cd\u4e3b\u8981\u7684\u76ae\u4e0b\u7528\u836f\u65b9\u6848\uff0c\u5df2\u5728\u75c7\u72b6\u8f7b\u5fae\u7684\u53bb\u52bf\u62b5\u6297\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u75d8\u82d7\u75c5\u6bd2\u4f5c\u4e3a\u4e3b\u8981\u514d\u75ab\u6cbb\u7597\u5242\uff0c\u968f\u540e\u662f\u4e00\u7cfb\u5217\u516d\u79cd\u79bd\u75d8\u75c5\u6bd2\u589e\u5f3a\u5242\uff0c\u5b83\u4eec\u90fd\u88ab\u8bbe\u8ba1\u6210\u8868\u8fbe\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\uff08PSA\uff09\u548c\u4e09\u79cd\u5171\u523a\u6fc0\u5206\u5b50\uff1aICAM-1\/CD54\u3001LFA-3\/CD58\u548cB7.1\/CD80\uff08\u79f0\u4e3a\u5171\u523a\u6fc0\u5206\u5b50\u7684TRIad\u6216TRICOM\uff09\u3002\u5728II\u671f\u7814\u7a76\u4e2d\uff0c\u53c2\u4e0e\u8005\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7PROSTVAC\u52a0GM-CSF\u6216\u7a7a\u767d\u8f7d\u4f53\u548c\u76d0\u6c34\u6ce8\u5c04\u7684\u5bf9\u7167\u7ec4\u3002\u5c3d\u7ba1\u4e24\u7ec4\u5728PFS\u65b9\u9762\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u57283\u5e74\u65f6\uff0c\u7814\u7a76\u836f\u7269\u7ec4\u7684\u751f\u5b58\u671f\u6bd4\u5bf9\u7167\u7ec4\u957f8.5\u4e2a\u6708\uff0c\u98ce\u9669\u6bd4\u4e3a0.56\uff08p=0.0061\uff09\u3002\u8fd9\u63a8\u52a8\u4e86\u7b2c\u4e09\u9636\u6bb5\u524d\u77bb\u6027\u8bd5\u9a8c\u7684\u5f00\u5c55\uff0c\u8be5\u8bd5\u9a8c\u5df2\u5b8c\u6210\u767b\u8bb0\uff0c\u9884\u8ba1\u5f88\u5feb\u5c31\u4f1a\u6709\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.5 \u9ebb\u75b9\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

MV-NIS\u662f\u8868\u8fbe\u4eba\u7532\u72b6\u817aNIS\uff08\u94a0\u94c1\u8f6c\u8fd0\u4f53\uff09\u7684Edmonston\u8c31\u7cfb\u9ebb\u75b9\u75c5\u6bd2\u7684\u5de5\u7a0b\u5316\u5f62\u5f0f\u3002NIS\u662f\u4e00\u79cd\u5728\u7532\u72b6\u817a\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u7684\u819c\u79bb\u5b50\u901a\u9053\uff0c\u6709\u52a9\u4e8e\u7898\u6355\u83b7\uff0c\u8fd9\u4e00\u7279\u5f81\u5bf9\u4e8e\u7532\u72b6\u817a\u626b\u63cf\uff08123I\u6216Technitium 99m\uff09\u6216\u6d88\u878d\uff08131I\uff09\u662f\u6709\u5229\u7684\u3002\u8fd9\u901a\u8fc7\u5408\u80de\u4f53\u5f62\u6210\u8bf1\u5bfc\u9009\u62e9\u6027\u764c\u7ec6\u80de\u6b7b\u4ea1\u3002\u5728\u4e00\u9879\u590d\u53d1\u3001\u8fdb\u5c55\u6027\u5375\u5de2\u4e0a\u76ae\u764c\u6216\u539f\u53d1\u6027\u8179\u819c\u764c\u7684I\u671f\u7814\u7a76\u4e2d\uff0c16\u540d\u63a5\u53d7MV-NIS\u6cbb\u7597\u7684\u60a3\u8005\u5e73\u5747OS\u4e3a26.5\u4e2a\u6708\uff0c\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f1\/2\u7ea7\u8179\u75db\u3001\u53d1\u70ed\u3001\u4e4f\u529b\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.6 \u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

PVSRIPO\u662f\u4e00\u79cd\u57fa\u56e0\u5de5\u7a0b\u7684\u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2Sabin 1\u578b\uff0c\u5176\u5185\u90e8\u6838\u7cd6\u4f53\u8fdb\u5165\u4f4d\u70b9\uff08IRES\uff09\u88ab\u4eba\u9f3b\u75c5\u6bd22\u578b\u7684IRES\u6240\u53d6\u4ee3\u3002\u8fd9\u79cd\u4fee\u9970\u6d88\u9664\u4e86\u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2\u7684\u795e\u7ecf\u6bd2\u529b\uff0c\u5e76\u9009\u62e9\u6027\u5730\u5728\u8868\u8fbeCD155\/Necl5(Necl5)\u7684\u7ec6\u80de\u4e2d\u590d\u5236\uff0c\u8fd9\u79cd\u5206\u5b50\u5728\u5b9e\u4f53\u764c\u4e2d\u53ef\u89c1\u3002\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5355\u6b21\u7624\u5185\u6ce8\u5c04PVSRIPO\u7684\u4e00\u671f\u7814\u7a76\u7684\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c1\u5e74\u603b\u751f\u5b58\u7387\u4e3a56%\uff0c\u6700\u5e38\u89c1\u76843\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u4e3a\u9ad8\u8840\u7cd6\u3001\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u548c\u504f\u762b\u30022016\u5e74\uff0c\u7f8e\u56fdFDA\u6388\u4e88PVSRIPO\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u4ee5\u4fc3\u8fdb\u8be5\u836f\u7269\u5728\u6f5c\u5728\u7684\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u65b9\u9762\u7684\u52a0\u901f\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.7 \u9006\u8f6c\u5f55\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

Vocimagene Amireptorepvec\u6216Toca 511\u662f\u4e00\u79cd\u57fa\u4e8e\u9f20\u767d\u8840\u75c5\u75c5\u6bd2\u7684\u975e\u6eb6\u89e3\u6027\u9006\u8f6c\u5f55\u75c5\u6bd2\uff0c\u5176\u57fa\u56e0\u5de5\u7a0b\u662f\u7f16\u7801\u80de\u5627\u5576\u8131\u6c28\u9176\u8f6c\u57fa\u56e0\u3002\u4e0e\u65b0\u578b\u53e3\u670d\u7f13\u91ca\u524d\u836f5-\u6c1f\u80de\u5627\u5576(TOCA FC)\u4e00\u8d77\u670d\u7528\uff0c\u5b83\u53ef\u4ee5\u50ac\u5316\u8be5\u524d\u836f\u8f6c\u5316\u4e3a5-\u6c1f\u5c3f\u5627\u5576\u300217\u4f8b\u4f7f\u7528Toca 511\u548cToca FC\u6cbb\u7597\u7684\u590d\u53d1\u6027\u9ad8\u7ea7\u522b\u80f6\u8d28\u7624\u60a3\u8005\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u53ea\u67091\u4f8b\u60a3\u8005\u76843\u7ea7\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u4e3a\u8840\u7ba1\u6e90\u6027\u6c34\u80bf\u3002\u7ecf\u6cbb\u7597\u540e\uff0c76%\u7684\u5207\u9664\u80bf\u7624\u4e2d\u53d1\u73b0\u75c5\u6bd2DNA\u3002\u4e0e\u4f7f\u7528\u5916\u90e8\u6d1b\u83ab\u53f8\u6c40\u7684\u5386\u53f2\u5bf9\u71677.1\u4e2a\u6708\u76f8\u6bd4\uff0c\u8be5\u65b9\u6848\u670913.6\u4e2a\u6708\u7684\u826f\u597dOS\u30022015\u5e74\uff0cToca 511\u548cToca FC\u88ab\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08USFDA\uff09\u6307\u5b9a\u4e3a\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u7f55\u7528\u836f\u30022017\u5e742\u6708\uff0c\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u4e3a\u8fd9\u4e9b\u6cbb\u7597\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u836f\u7269\u8fdb\u884c\u4e86\u7a81\u7834\u6027\u7684\u8ba4\u5b9a\u3002\u4e00\u9879II\/III\u671f\u8bd5\u9a8c\uff08Toca 5\uff09\u5c06Toca 511\u548cToca FC\u4e0e\u63a5\u53d7\u624b\u672f\u7684\u590d\u53d1\u6027\u795e\u7ecf\u80f6\u8d28\u7624\u7684\u62a4\u7406\u6807\u51c6\u8fdb\u884c\u6bd4\u8f83\uff0c\u8be5\u8bd5\u9a8c\u5df2\u5b8c\u6210\u767b\u8bb0\uff0c\u9884\u8ba1\u5c06\u4e8e2018\u5e74\u4e0a\u534a\u5e74\u53d6\u5f97\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

24.3.8 \u7ec6\u5c0f\u75c5\u6bd2<\/p>\n<\/section>\n

\n
\n
\n

\u7ec6\u5c0f\u75c5\u6bd2H-1(H-1PV)\u662f\u4e00\u79cd\u556e\u9f7f\u52a8\u7269\u5355\u94feDNA\u75c5\u6bd2\uff0c\u5bf9\u4eba\u7c7b\u65e0\u81f4\u75c5\u6027\uff0c\u5df2\u77e5\u53ef\u6fc0\u6d3bCaspin\u4ecb\u5bfc\u7684\u764c\u7ec6\u80de\u6b7b\u4ea1\u9014\u5f84\u3002\u5728\u4e00\u9879\u5355\u4e2d\u5fc3\u7684I\/IIa\u671f\u8bd5\u9a8c\u4e2d\uff0c\u80bf\u7624\u5185\u6216\u9759\u8109\u6ce8\u5c04H-1PV\u6cbb\u7597\u8fdb\u5c55\u6027\u539f\u53d1\u6216\u590d\u53d1\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\uff0c\u6ca1\u6709\u53d1\u73b0\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u300233%\u7684\u53c2\u4e0e\u8005\u7684PFS\u4e3a6\u4e2a\u6708\u6216\u4ee5\u4e0a\uff0c80%\u7684\u53c2\u4e0e\u8005\u67096\u4e2a\u6708\u4ee5\u4e0a\u7684OS\u3002\u8be5\u8bd5\u9a8c\u5df2\u5b8c\u6210\u767b\u8bb0\uff0c\u6700\u7ec8\u7ed3\u679c\u5c1a\u5f85\u516c\u5e03\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u4e00\u9879\u9488\u5bf9\u4e0d\u80fd\u624b\u672f\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u4f7f\u7528H-1PV\u7684I\/II\u671f\u8bd5\u9a8c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Rutika Mehta and Igor Puzanov<\/span><\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u674e\u5b89\u742a \u6f58\u541b\u541b<\/span><\/span><\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u90ed\u5b50<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a \u80bf\u7624\u514d\u75ab\u5b66-\u7b2c24\u7ae0\uff1a\u6eb6\u7624\u75c5\u6bd2\uff1aT-VEC\u548c\u5176\u4ed6\uff08\u4e0a\uff09 24.2.6 \u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c \u5728\u5bf9436\u540d\u4e0d…<\/p>\n","protected":false},"author":1,"featured_media":3206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3208"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3208"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3208\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3206"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3208"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}