{"id":3434,"date":"2024-04-06T11:10:44","date_gmt":"2024-04-06T03:10:44","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2024\/04\/06\/nat-commun%ef%bc%9a%e8%a1%b0%e8%80%81%e9%80%9a%e8%bf%87%e8%af%b1%e5%af%bc%e5%85%8d%e7%96%ab%e6%8a%91%e5%88%b6%e6%80%a7%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e5%af%bc%e8%87%b4%e5%85%8d%e7%96%ab\/"},"modified":"2024-04-06T11:10:44","modified_gmt":"2024-04-06T03:10:44","slug":"nat-commun%ef%bc%9a%e8%a1%b0%e8%80%81%e9%80%9a%e8%bf%87%e8%af%b1%e5%af%bc%e5%85%8d%e7%96%ab%e6%8a%91%e5%88%b6%e6%80%a7%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e5%af%bc%e8%87%b4%e5%85%8d%e7%96%ab","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2024\/04\/06\/nat-commun%ef%bc%9a%e8%a1%b0%e8%80%81%e9%80%9a%e8%bf%87%e8%af%b1%e5%af%bc%e5%85%8d%e7%96%ab%e6%8a%91%e5%88%b6%e6%80%a7%e8%82%bf%e7%98%a4%e5%be%ae%e7%8e%af%e5%a2%83%e5%af%bc%e8%87%b4%e5%85%8d%e7%96%ab\/","title":{"rendered":"Nat Commun\uff1a\u8870\u8001\u901a\u8fc7\u8bf1\u5bfc\u514d\u75ab\u6291\u5236\u6027\u80bf\u7624\u5fae\u73af\u5883\u5bfc\u81f4\u514d\u75ab\u6cbb\u7597\u6297\u6027"},"content":{"rendered":"
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\u524d\u671f\u7cbe\u5f69\u5185\u5bb9\uff1a<\/span><\/p>\n

Cancer Cell\uff1a\u901a\u8fc7mRNA\u6280\u672f\u7f16\u7801\u6301\u4e45\u6027IL-2\u5728MHC I\u7c7b\u5206\u5b50\u7f3a\u9677\u764c\u75c7\u4e2d\u53ef\u6062\u590d\u9488\u5bf9\u65b0\u6297\u539f\u7684CD8+ T\u7ec6\u80de\u53cd\u5e94<\/span><\/a><\/span><\/p>\n

Nature\uff1a\u4f24\u5bb3\u611f\u53d7\u795e\u7ecf\u5143\u5f71\u54cd\u80bf\u7624\u514d\u75ab\u76d1\u89c6<\/span><\/a><\/span><\/p>\n

Cell Metab\uff1a\u996e\u98df\u4e2d\u7684\u53cd\u5f0f\u6cb9\u9178\u901a\u8fc7ACSL5\u589e\u5f3a\u80bf\u7624\u6297\u539f\u5448\u9012\u548c\u6297\u80bf\u7624\u514d\u75ab<\/span><\/a><\/span><\/p>\n

Science\uff1a\u80bf\u7624\u6811\u7a81\u72b6\u7ec6\u80de\u4e2d\u524d\u4f53\u8102\u86cb\u767d\u7684\u9ad8\u5ea6\u7cd6\u57fa\u5316\u9a71\u52a8\u514d\u75ab\u9003\u9038<\/span><\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6742\u5fd7\u540d\u79f0<\/strong>\uff1aNat Commun.<\/span><\/p>\n

\u53d1\u8868\u65e5\u671f<\/strong>\uff1a2024.03.18<\/p>\n

DOI<\/strong>\uff1a10.1038\/s41467-024-46769-9.<\/p>\n

PubMed<\/strong>\uff1ahttps:\/\/pubmed.ncbi.nlm.nih.gov\/38499573\/<\/p>\n

\u5f71\u54cd\u56e0\u5b50<\/strong>\uff1a16.6<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5185\u5bb9\u7b80\u4ecb<\/strong><\/p>\n<\/section>\n

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\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7684\u6f5c\u529b\u53ef\u80fd\u5728\u514d\u75ab\u7ec6\u80de\u5065\u5eb7\u53d7\u635f\u7684\u60c5\u51b5\u4e0b\u53d7\u5230\u9650\u5236\u3002\u7814\u7a76\u8868\u660e\uff0c\u7531\u4e8e\u5728\u5c0f\u9f20\u4e2d\u548c\u6cbb\u7597\u8bf1\u5bfc\u7684\u7ec6\u80de\u8870\u8001\uff08TIS\uff09\u80cc\u666f\u4e0b\u79ef\u7d2f\u7684\u8870\u8001\u7ec6\u80de\uff0c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u53d7\u5230\u4e86\u5f71\u54cd\u3002\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u6297\u6027\u4e0e\u80bf\u7624\u5185CD8 T\u7ec6\u80de\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\u51cf\u5c11\u76f8\u5173\u3002\u6d88\u9664\u8870\u8001\u7ec6\u80de\u53ef\u4ee5\u6062\u590d\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u5185\u7684\u514d\u75ab\u7a33\u6001\uff0c\u5e76\u589e\u52a0\u5c0f\u9f20\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u751f\u5b58\u53cd\u5e94\u3002\u901a\u8fc7\u4f7f\u7528\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\uff0c\u89c2\u5bdf\u5230ABT263\uff08Navitoclax\uff09\u6ce8\u5c04\u53ef\u4ee5\u9006\u8f6cTME\u4e2d\u9ad3\u7cfb\u7ec6\u80de\u7684\u52a0\u5267\u7684\u514d\u75ab\u6291\u5236\u6027\u7279\u5f81\u3002\u8fd9\u4e9b\u9ad3\u7cfb\u7ec6\u80de\u7684\u6d88\u9664\u4e5f\u5728\u4f53\u5916\u6062\u590d\u4e86CD8 T\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u5e76\u5728\u4f53\u5185\u6d88\u9664\u4e86\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u6297\u6027\u3002\u603b\u7684\u6765\u8bf4\uff0c\u8be5\u7814\u7a76\u8868\u660e\uff0c\u5728ICI\u6cbb\u7597\u524d\u4f7f\u7528\u6e05\u9664\u8870\u8001\u7ec6\u80de\u7684\u836f\u7269\u53ef\u80fd\u6784\u6210\u4e00\u79cd\u836f\u7406\u5b66\u65b9\u6cd5\uff0c\u4ee5\u63d0\u9ad8\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u6709\u6548\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u521b\u65b0\u6027\u53ca\u7814\u7a76\u610f\u4e49<\/strong><\/p>\n<\/section>\n

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\u8fd9\u7bc7\u6587\u7ae0\u7684\u6838\u5fc3\u521b\u65b0\u6027\u5728\u4e8e\u63ed\u793a\u4e86\u7ec6\u80de\u8870\u8001\uff08senescence\uff09\u5728\u8bf1\u5bfc\u514d\u75ab\u6cbb\u7597\u6297\u6027\u4e2d\u7684\u5173\u952e\u4f5c\u7528\uff0c\u5e76\u901a\u8fc7\u5b9e\u9a8c\u8bc1\u660e\u4e86\u6d88\u9664\u8870\u8001\u7ec6\u80de\u80fd\u591f\u6062\u590d\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u514d\u75ab\u7a33\u6001\uff0c\u4ece\u800c\u589e\u5f3a\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u3002\u7814\u7a76\u663e\u793a\uff0c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u8870\u8001\u7ec6\u80de\u7684\u79ef\u7d2f\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u6297\u6027\u5bc6\u5207\u76f8\u5173\uff0c\u8fd9\u4e3b\u8981\u4f53\u73b0\u5728\u80bf\u7624\u5185CD8 T\u7ec6\u80de\u7684\u79ef\u7d2f\u548c\u6fc0\u6d3b\u51cf\u5c11\u4e0a\u3002<\/p>\n

\u7814\u7a76\u610f\u4e49\u65b9\u9762\uff0c\u8fd9\u9879\u5de5\u4f5c\u4e3a\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u9886\u57df\u63d0\u4f9b\u4e86\u65b0\u7684\u89c6\u89d2\u548c\u5e72\u9884\u624b\u6bb5\u3002\u901a\u8fc7\u4f7f\u7528\u6e05\u9664\u8870\u8001\u7ec6\u80de\u7684\u836f\u7269ABT263\uff08Navitoclax\uff09\uff0c\u80fd\u591f\u9006\u8f6c\u9ad3\u7cfb\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u6027\u7279\u5f81\uff0c\u6062\u590dCD8 T\u7ec6\u80de\u7684\u589e\u6b96\u80fd\u529b\uff0c\u5e76\u5728\u4f53\u5185\u6709\u6548\u514b\u670d\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u6297\u6027\u3002\u8fd9\u4e3a\u63d0\u9ad8\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u6709\u6548\u6027\u63d0\u4f9b\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u836f\u7406\u5b66\u7b56\u7565\uff0c\u5373\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u6cbb\u7597\u524d\u4f7f\u7528\u6e05\u9664\u8870\u8001\u7ec6\u80de\u7684\u836f\u7269\uff0c\u4ece\u800c\u589e\u5f3a\u6cbb\u7597\u6548\u679c\uff0c\u5bf9\u4e8e\u764c\u75c7\u6cbb\u7597\u5177\u6709\u91cd\u8981\u7684\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe1\uff1a\u8870\u8001\u5bfc\u81f4\u514d\u75ab\u7597\u6cd5\u6297\u6027\u589e\u5f3a<\/strong><\/p>\n

a <\/strong>\u5b9e\u9a8c\u793a\u610f\u56fe\u3002\u7b80\u8981\u6765\u8bf4\uff0c\u901a\u8fc7\u7ed9p16-3MR\u5c0f\u9f20\u65bd\u52a0\u4e00\u6b216.5 Gy\u7684\u6b21\u81f4\u6b7b\u5242\u91cf\u5168\u8eab\u7167\u5c04\uff08TBI\uff09\u6216\u6ce8\u5c04\u591a\u67d4\u6bd4\u661f\uff08Doxo\uff0c10mg\/kg\uff09\u6765\u8bf1\u5bfc\u8870\u8001\u3002\u5728TBI\u540e12\u5468\u6216\u591a\u67d4\u6bd4\u661f\u6ce8\u5c04\u540e4\u5468\uff0c\u5c0f\u9f20\u901a\u8fc7\u8179\u8154\u6ce8\u5c04GCV\uff0825mg\/kg\uff09\u8fde\u7eed5\u5929\uff0c\u4ee5\u6e05\u9664\u8870\u8001\u7ec6\u80de\u3002\u5728\u6700\u540e\u4e00\u6b21\u6ce8\u5c04GCV\u540e5\u5929\uff0c\u5c0f\u9f20\u5728\u6bcf\u4fa7\u80c1\u90e8\u5206\u522b\u6ce8\u5c045\u00d7105<\/sup>\u4e2a\u8868\u8fbemPlum\u8367\u5149\u86cb\u767d\u7684MC38\u80bf\u7624\u7ec6\u80de\u3002\u5728\u7b2c9\u5929\u548c\u7b2c12\u5929\uff0c\u5bf9\u5c0f\u9f20\u6ce8\u5c04\u03b1PD-L1\u963b\u65ad\u6297\u4f53\uff0c\u5e76\u6301\u7eed\u89c2\u5bdf\u80bf\u7624\u751f\u957f\u76f4\u81f3\u8fbe\u5230\u9650\u5236\u70b9\u3002<\/p>\n

b <\/strong>\u901a\u8fc7RT-qPCR\u5b9a\u91cf\u6d4b\u5b9a\u4e86TBI\u6216\u591a\u67d4\u6bd4\u661f\u5904\u7406\u540e10\u5468\u548c4\u5468\u813e\u810f\u4e2dp16\u548cp21\u7684\u76f8\u5bf9\u8868\u8fbe\u91cf\u3002CTL\u7ec49\u4e2a\u6837\u672c\uff0cTBI\u7ec46\u4e2a\u6837\u672c\uff1bDoxo\u7ec4\u5206\u522b\u4e3a7\u4e2a\u548c6\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002Doxo\u7ec4\u91c7\u7528\u53cc\u5c3e\u975e\u914d\u5bf9T\u68c0\u9a8c\u8fdb\u884cp16\/p21\u7684\u7edf\u8ba1\uff0c\u800cTBI\u7ec4\u91c7\u7528Mann-Whitney\u68c0\u9a8c\u3002\u6570\u636e\u4ee5\u5747\u503c\u00b1SEM\u663e\u793a\u3002<\/p>\n

c<\/strong> \u5728GCV\u5904\u7406\u524d\u540e\uff0c\u901a\u8fc7\u751f\u7269\u53d1\u5149\u6d4b\u91cfp16-3MR\u5c0f\u9f20\u813e\u810f\u4e2dp16\u7684\u8868\u8fbe\u3002CTL\u7ec45\u4e2a\u6837\u672c\uff0cCTL+GCV\u7ec45\u4e2a\u6837\u672c\uff0cTBI\u7ec47\u4e2a\u6837\u672c\uff0cTBI+GCV\u7ec46\u4e2a\u6837\u672c\uff0cDoxo\u7ec47\u4e2a\u6837\u672c\uff0cDoxo+GCV\u7ec44\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c\u00b1SEM\u663e\u793a\u3002<\/p>\n

d<\/strong> \u5c55\u793a\u4e86CTL\u5c0f\u9f2025\u5929\u5185\u53caTBI\/Doxo\u5c0f\u9f2028\u5929\u5185\u7684\u5e73\u5747\u80bf\u7624\u751f\u957f\u91cf\u00b1SEM\u3002\u672a\u7ecfTBI\u6216Doxo\u5904\u7406\u7684\u5bf9\u7167\u5c0f\u9f20\u6807\u8bb0\u4e3aCTL\u3002\u62ec\u53f7\u5185\u663e\u793a\u6bcf\u7ec4\u7684\u80bf\u7624\u603b\u6570\u3002\u91c7\u7528\u6df7\u5408\u6548\u5e94\u5206\u6790\u6216\u53cc\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002<\/p>\n

e<\/strong> \u5c55\u793a\u4e86\u6240\u6307\u65f6\u95f4\u70b9\u6bcf\u4e2a\u5355\u72ec\u80bf\u7624\u7684\u5927\u5c0f\u3002\u62ec\u53f7\u5185\u663e\u793a\u6bcf\u7ec4\u7684\u80bf\u7624\u603b\u6570\u3002<\/p>\n

f <\/strong>CTL\u3001TBI\u548cDoxo\u5c0f\u9f20\u5728\u5404\u6307\u5b9a\u6761\u4ef6\u4e0b\u7684Kaplan-Meyer\u751f\u5b58\u66f2\u7ebf\u3002\u62ec\u53f7\u5185\u663e\u793a\u6bcf\u7ec4\u7684\u5c0f\u9f20\u603b\u6570\u3002\u91c7\u7528Log-rank (Mantel-Cox\u68c0\u9a8c)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56fe2\uff1a\u4f7f\u7528ABT263\u6cbb\u7597\u6d88\u9664\u8870\u8001\u7ec6\u80de\u6539\u5584\u4e86\u53d7\u7167\u5c04\u5c0f\u9f20\u7684\u03b1PD-L1\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u6548\u679c<\/strong><\/p>\n

a <\/strong>\u5b9e\u9a8c\u793a\u610f\u56fe\u3002\u7b80\u8981\u6765\u8bf4\uff0c\u901a\u8fc7\u6b21\u81f4\u6b7b\u5242\u91cf\u7684TBI\u8bf1\u5bfc\u8870\u8001\uff0c10\u5468\u540e\u5c0f\u9f20\u901a\u8fc7\u80c3\u7ba1\u704c\u6ce8\u63a5\u53d7ABT263\uff0850 mg\/kg\uff09\u6cbb\u7597\uff0c\u5206\u4e24\u4e2a\u5468\u671f\uff0c\u6bcf\u4e2a\u5468\u671f\u8fde\u7eed5\u5929\uff0c\u4ee5\u6e05\u9664\u8870\u8001\u7ec6\u80de\u3002\u6700\u540e\u4e00\u6b21\u704c\u6ce8\u540e5\u5929\uff0c\u5c0f\u9f20\u8981\u4e48\u88ab\u727a\u7272\u4ee5\u5916\u90e8\u6d4b\u91cf\u813e\u810f\u4e2d\u7684\u8870\u8001\u60c5\u51b5\uff0c\u8981\u4e48\u6ce8\u5c04MC38\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n

b <\/strong>\u901a\u8fc7\u751f\u7269\u53d1\u5149\u6280\u672f\u8bc4\u4f30ABT263\u5904\u7406\u524d\u540e\u813e\u810f\u4e2dp16\u8868\u8fbe\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002CTL\u7ec47\u4e2a\u6837\u672c\uff0cCTL + ABT263\u7ec43\u4e2a\u6837\u672c\uff0cTBI\u7ec48\u4e2a\u6837\u672c\uff0cTBI + ABT263\u7ec47\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002<\/p>\n

c <\/strong>\u901a\u8fc7qPCR\u6280\u672f\u8bc4\u4f30ABT263\u5904\u7406\u524d\u540e\u813e\u810f\u4e2dp16\u548cp21\u7684\u8868\u8fbe\u3002CTL\u7ec411\u4e2a\u6837\u672c\uff0cCTL + ABT263\u7ec46\u4e2a\u6837\u672c\uff0cTBI\u7ec415\u4e2a\u6837\u672c\uff0cTBI + ABT263\u7ec413\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n

d <\/strong>\u8bc4\u4f30\u5404\u6307\u5b9a\u5c0f\u9f20\u7ec4\u7684\u80bf\u7624\u751f\u957f\u3002\u6bcf\u6761\u7ebf\u4ee3\u886825\u5929\u5185\u6216\u76f4\u81f3\u5fc5\u987b\u4ece\u7814\u7a76\u4e2d\u79fb\u9664\u8be5\u5c0f\u9f20\u4e3a\u6b62\u7684\u80bf\u7624\u5e73\u5747\u751f\u957f\u91cf \u00b1 SEM\u3002\u62ec\u53f7\u5185\u663e\u793a\u6bcf\u7ec4\u7684\u80bf\u7624\u603b\u6570\u3002\u91c7\u7528\u6df7\u5408\u6548\u5e94\u5206\u6790\u6216\u53cc\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002<\/p>\n

e <\/strong>\u5c55\u793a\u4e86\u6240\u6307\u65f6\u95f4\u70b9\u6bcf\u4e2a\u5355\u72ec\u80bf\u7624\u7684\u5927\u5c0f\u3002\u672a\u7ecfTBI\u5904\u7406\u7684\u5c0f\u9f20\u6807\u8bb0\u4e3a\u5bf9\u7167\u7ec4\uff08CTL\uff09\u3002\u62ec\u53f7\u5185\u663e\u793a\u6bcf\u7ec4\u7684\u80bf\u7624\u603b\u6570\u3002<\/p>\n

f <\/strong>\u5c55\u793a\u4e86\u5bf9\u7167\u7ec4\u548cTBI\u5c0f\u9f20\u5728\u5404\u6307\u5b9a\u6761\u4ef6\u4e0b\u7684Kaplan\u2013Meyer\u751f\u5b58\u66f2\u7ebf\u3002\u91c7\u7528Log-rank (Mantel-Cox\u68c0\u9a8c)\u3002<\/p>\n

g <\/strong>\u5728\u63a5\u79cd\u540e\u7b2c14\u5929\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u5206\u6790\u80bf\u7624\u89e3\u79bb\u540e\u7684\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u60c5\u51b5\u3002\u6570\u636e\u663e\u793aCD45+\u7ec6\u80de\u7fa4\u4e2dCD4 T\u7ec6\u80de\u3001CD8 T\u7ec6\u80de\u548cCD11b+\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002CTL\u7ec47\u4e2a\u6837\u672c\uff0cCTL (\u03b1PD-L1)\u7ec411\u4e2a\u6837\u672c\uff0cCTL + ABT263 (\u03b1PD-L1)\u7ec4\u517112\u4e2a\u6837\u672c\uff0cTBI\u7ec48\u4e2a\u6837\u672c\uff0cTBI (\u03b1PD-L1)\u7ec414\u4e2a\u6837\u672c\uff0cTBI + ABT263 (\u03b1PD-L1)\u7ec4\u517114\u4e2a\u6837\u672c\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n

h <\/strong>\u5c55\u793a\u4e86\u80bf\u7624\u4e2dCD8 T\u7ec6\u80de\u4e0eCD11b+\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002\u6570\u636e\u6765\u6e90\u540cg\u3002\u91c7\u7528Brown-Forsythe\u548cWelch ANOVA\u5206\u6790\u5e76\u8fdb\u884cGames-Howell\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/section>\n<\/section>\n
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\u56fe3\uff1aABT263\u6062\u590d\u4e86\u4e4b\u524d\u53d7\u7167\u5c04\u5c0f\u9f20\u4e2d\u53d7\u635f\u7684\u8fdc\u7aef\u6740\u4f24\u6548\u5e94<\/strong><\/p>\n

a <\/strong>\u5b9e\u9a8c\u793a\u610f\u56fe\u3002\u7ecf\u6216\u672a\u7ecfABT263\u5904\u7406\u7684CTL\u6216TBI\u5c0f\u9f20\u5728\u6bcf\u4fa7\u80c1\u90e8\u63a5\u79cd\u4e863\u62165 \u00d7 105<\/sup>\u4e2aMC38\u80bf\u7624\u7ec6\u80de\u3002\u5728\u80bf\u7624\u63a5\u79cd\u540e\u7684\u7b2c12\u300113\u548c14\u5929\uff0c\u5bf9\u8f83\u5927\u7684\u539f\u53d1\u6027\u80bf\u7624\u8fdb\u884c\u4e863\u8f6e\uff08\u6bcf\u8f6e8Gy\uff09\u7684\u653e\u5c04\u6cbb\u7597\uff08RT\uff09\u3002\u7136\u540e\u5728\u7b2c14\u300117\u548c20\u5929\u7ed9\u5c0f\u9f20\u6ce8\u5c04\u03b1CTLA-4\u963b\u65ad\u6297\u4f53\uff0c\u5e76\u8bc4\u4f30\u80bf\u7624\u751f\u957f\u76f4\u81f3\u8fbe\u5230\u9650\u5236\u70b9\u3002\u53e6\u5916\uff0c\u4e00\u4e9b\u5c0f\u9f20\u5728\u7b2c22\u5929\u88ab\u5b89\u4e50\u6b7b\uff0c\u5e76\u624b\u672f\u79fb\u9664\u80bf\u7624\u4ee5\u5206\u6790\u514d\u75ab\u6d78\u6da6\u3002<\/p>\n

b <\/strong>\u8bc4\u4f30\u4e86\u5404\u6307\u5b9a\u5c0f\u9f20\u7ec4\u7684\u80bf\u7624\u751f\u957f\u3002\u6bcf\u6761\u7ebf\u4ee3\u8868\u4e00\u4e2a\u5355\u72ec\u80bf\u7624\u572828\u5929\u5185\u6216\u76f4\u5230\u5fc5\u987b\u5c06\u5c0f\u9f20\u4ece\u7814\u7a76\u4e2d\u79fb\u9664\u4e3a\u6b62\u7684\u751f\u957f\u60c5\u51b5\u3002\u62ec\u53f7\u5185\u663e\u793a\u6bcf\u7ec4\u7684\u80bf\u7624\u603b\u6570\u3002\u91c7\u7528\u53cc\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n

c <\/strong>\u4e3a\u6bcf\u79cd\u6307\u5b9a\u6761\u4ef6\u7ed8\u5236\u7684Kaplan\u2013Meyer\u751f\u5b58\u66f2\u7ebf\u3002<\/p>\n

d <\/strong>\u76f4\u65b9\u56fe\u663e\u793a\u4e86\u6bcf\u7ec4\u4e2d\u5b9e\u73b0\u5b8c\u5168\u7684\u6b21\u751f\uff08\u8fdc\u9694\uff09\u80bf\u7624\u6d88\u9664\uff08CE\uff09\u7684\u5c0f\u9f20\u6bd4\u4f8b\u3002<\/p>\n

e <\/strong>\u5c55\u793a\u4e86\u7b2c22\u5929\u5728\u89e3\u79bb\u524d\u7684\u6b21\u751f\u80bf\u7624\u91cd\u91cf\u3002CTL\u7ec429\u4e2a\u6837\u672c\uff0cCTL (RT + \u03b1CTLA4)\u7ec417\u4e2a\u6837\u672c\uff0cCTL + ABT263\u7ec415\u4e2a\u6837\u672c\uff0cCTL + ABT263 (RT + \u03b1CTLA4)\u7ec45\u4e2a\u6837\u672c\uff0cTBI\u7ec429\u4e2a\u6837\u672c\uff0cTBI (RT + \u03b1CTLA4)\u7ec419\u4e2a\u6837\u672c\uff0cTBI + ABT263\u7ec416\u4e2a\u6837\u672c\uff0cTBI + ABT263 (RT + \u03b1CTLA4)\u7ec419\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002\u91c7\u7528Brown-Forsythe\u548cWelch ANOVA\u68c0\u9a8c\u5e76\u8fdb\u884cGames-Howell\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n

f <\/strong>\u5728\u63a5\u79cd\u540e\u7b2c22\u5929\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u4ece\u89e3\u79bb\u7684\u80bf\u7624\u4e2d\u786e\u5b9a\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u60c5\u51b5\u3002\u5c55\u793a\u4e86CD8 T\u7ec6\u80de\u3001CD4 T\u7ec6\u80de\u548cCD11b+\u7ec6\u80de\u76f8\u5bf9\u4e8e\u4ece\u80bf\u7624\u4e2d\u6536\u96c6\u7684CD45+\u7ec6\u80de\u603b\u6570\u7684\u6bd4\u4f8b\u3002\u5bf9\u4e8eCD8\u548cCD4\uff0cCTL\u7ec429\u4e2a\u6837\u672c\uff0cCTL (RT + \u03b1CTLA4)\u7ec417\u4e2a\u6837\u672c\uff0cCTL + ABT263\u7ec4\u53caCTL + ABT263 (RT + \u03b1CTLA4)\u7ec4\u517110\u4e2a\u6837\u672c\uff0cTBI\u7ec424\u4e2a\u6837\u672c\uff0cTBI (RT + \u03b1CTLA4)\u7ec417\u4e2a\u6837\u672c\uff0cTBI + ABT263\u7ec4\u53caTBI + ABT263 (RT + \u03b1CTLA4)\u7ec4\u517134\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002\u5bf9\u4e8eCD11b\uff0c\u6570\u636e\u6765\u6e90\u540c\u4e0a\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n

g <\/strong>\u5c55\u793a\u4e86\u7b2c22\u5929\u80bf\u7624\u4e2dCD8 T\u7ec6\u80de\u4e0eCD11b+\u7ec6\u80de\u7684\u6bd4\u4f8b\u3002\u6570\u636e\u6765\u6e90\u540cf\u3002\u91c7\u7528Brown-Forsythe\u548cWelch ANOVA\u5206\u6790\u5e76\u8fdb\u884cGames-Howell\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n

h <\/strong>\u5c55\u793a\u4e86\u7b2c22\u5929\u6d78\u6da6CD8 T\u7ec6\u80de\u4e2dIFN\u03b3\u8868\u8fbe\u7684\u5b9a\u91cf\uff0c\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u6d4b\u91cf\u3002CTL\u7ec44\u4e2a\u6837\u672c\uff0cCTL (RT + \u03b1CTLA4)\u7ec48\u4e2a\u6837\u672c\uff0cCTL + ABT263\u7ec4\u53caCTL + ABT263 (RT + \u03b1CTLA4)\u7ec4\u51718\u4e2a\u6837\u672c\uff0cTBI\u7ec44\u4e2a\u6837\u672c\uff0cTBI (RT + \u03b1CTLA4)\u7ec48\u4e2a\u6837\u672c\uff0cTBI + ABT263\u7ec44\u4e2a\u6837\u672c\uff0cTBI + ABT263 (RT + \u03b1CTLA4)\u7ec48\u4e2a\u72ec\u7acb\u52a8\u7269\u6837\u672c\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\u56fe4\uff1aABT263\u6cbb\u7597\u540e\uff0c\u5355\u6838\u7ec6\u80de\u7684\u514d\u75ab\u6291\u5236\u8868\u578b\u90e8\u5206\u6062\u590d<\/strong><\/p>\n

a <\/strong>\u5728\u63a5\u79cd\u540e\u7b2c22\u5929\u6536\u96c6\u6307\u5b9a\u5c0f\u9f20\u7ec4\u7684\u80bf\u7624\u5e76\u8fdb\u884c\u89e3\u79bb\u3002\u975e\u80bf\u7624\u751f\u6210\u7ec6\u80de\uff08\u79f0\u4e3a\u80bf\u7624\u5fae\u73af\u5883\u7ec6\u80de\uff09\u88ab\u5206\u9009\u5e76\u7528\u4e8e\u4e24\u4e2a\u72ec\u7acb\u5b9e\u9a8c\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5206\u6790\u3002\u6bcf\u7ec4\u5305\u542b\u6765\u81ea\u4e09\u4e2a\u80bf\u7624\u7684\u7ec6\u80de\u6c60\u3002\u6bcf\u7ec4\u5206\u6790\u4e86\u5927\u7ea610000\u4e2a\u7ec6\u80de\u3002<\/p>\n

b <\/strong>\u901a\u8fc7R-studio\u4e2d\u7684Seurat\u5305\uff0c\u751f\u6210\u4e8612\u4e2a\u4e0d\u540c\u7684\u7c07\uff0c\u4ee3\u8868\u4e86\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u51e0\u4e4e\u6240\u6709\u7684\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7c07\u901a\u8fc7U-MAP\u8868\u793a\u5b9a\u4f4d\u3002<\/p>\n

c <\/strong>\u5c55\u793a\u4e86\u4e00\u4e2aDotPlot\uff0c\u5217\u51fa\u4e86\u7528\u4e8e\u8bc6\u522bb\u9762\u677f\u4e2d\u751f\u6210\u7684\u7ec6\u80de\u7c07\u7684\u57fa\u56e0\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n

d <\/strong>\u5c55\u793a\u4e86\u4ece\u6240\u6709\u5206\u6790\u7ec6\u80de\u4e2d\u5355\u4e2a\u7ec6\u80de\u7fa4\u4f53\u7684\u6bd4\u4f8b\u3002<\/p>\n

e <\/strong>UpsetPlot\u663e\u793a\u4e86\u5728\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548cCD8 T\u7ec6\u80de\u6837\u672c\u6bd4\u8f83\u540e\u7684\u4ea4\u4e92\u4f5c\u7528\u5927\u5c0f\uff08\u5dee\u5f02\u8868\u8fbe\u57fa\u56e0\u7684\u6570\u91cf\uff09\u3002<\/p>\n

f <\/strong>\u5728ABT\u5904\u7406\u7684\u5c0f\u9f20\u4e2d\u6062\u590d\u8868\u8fbe\u7684\u5355\u6838\u7ec6\u80de\u7c07\u4e2d\u768463\u4e2a\u57fa\u56e0\u4e2d\uff0c\u6839\u636e\u5b83\u4eec\u4e0e\u514d\u75ab\u6291\u5236\/\u514d\u75ab\u7597\u6cd5\u6297\u6027\u7684\u5173\u8054\u9009\u62e9\u4e8613\u4e2a\u3002\u5b83\u4eec\u7684\u4e2a\u4f53\u8868\u8fbe\u60c5\u51b5\u901a\u8fc7RidgePlot\u5c55\u793a\uff0c\u4ee5\u6f14\u793a\u8fd9\u4e9b\u5355\u6838\u7ec6\u80de\u7684\u6574\u4f53\u514d\u75ab\u6291\u5236\u8868\u578b\u3002\u8fc7\u8868\u8fbe\u57fa\u56e0\u7684\u5168\u5c40\u8868\u8fbe\uff08\u4e0d\u5305\u62ecAtf3\uff09\u6784\u6210\u4e86TBI-\u5355\u6838\u7ec6\u80de-\u7279\u5f81\uff0c\u5e76\u901a\u8fc7ViolinPlot\u8868\u793a\u3002<\/p>\n

g <\/strong>\u5728f\u9762\u677f\u4e2d\u8bc6\u522b\u7684TBI-\u5355\u6838\u7ec6\u80de-\u7279\u5f81\u5728\u6574\u4e2a\u7ec6\u80de\u4e2d\u901a\u8fc7FeaturePlot\u8fdb\u884c\u91cf\u5316\uff0c\u4ee5\u7a81\u51fa\u5728b\u9762\u677f\u4e2d\u5b9a\u4e49\u7684\u5355\u6838\u7ec6\u80de\u7c07\u5185\u7684\u8868\u8fbe\u3002<\/p>\n

h <\/strong>\u4f7f\u7528Zhang\u7b49\u4eba\u5728\u8001\u9f84\uff0820-22\u4e2a\u6708\u5927\uff09\u548c\u5e74\u8f7b\uff086-8\u5468\u5927\uff09\u5c0f\u9f20\u4e2d\u6536\u96c6\u7684B16F10\u80bf\u7624\u4e2d\u751f\u6210\u7684\u5355\u7ec6\u80de\u6570\u636e\u96c6\uff0c\u901a\u8fc7\u5c0f\u63d0\u7434\u56fe\u5206\u6790TBI-\u5355\u6838\u7ec6\u80de-\u7279\u5f81\u5728\u5355\u6838\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\u56fe5\uff1aABT263\u53ef\u90e8\u5206\u6062\u590d\u5355\u6838\u7ec6\u80de\u4ecb\u5bfc\u7684CD8 T\u7ec6\u80de\u6fc0\u6d3b\u548c\u589e\u6b96\u53d7\u635f<\/strong><\/p>\n

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d <\/strong>\u793a\u610f\u56fe\u8868\u793a\u5728\u6fc0\u6d3b\u73e0\u523a\u6fc0\u4e0b\uff0c\u6765\u6e90\u4e8e\u6307\u5b9a\u7ec4\u7684\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u6709\u6216\u6ca1\u6709\u9ad3\u7cfb\u7ec6\u80de\uff08CD11b+\uff09\u7684CFSE\u67d3\u8272CD8 T\u7ec6\u80de\u7684\u4f53\u5916\u589e\u6b96\u80fd\u529b\u3002\u4f7f\u7528FlowJo\u8f6f\u4ef6\u548c\u589e\u6b96\u5de5\u5177\u8bc4\u4f30\u589e\u6b96\u6027CD8 T\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u3002CTL\u7ec49\u4e2a\u6837\u672c\uff0cCTL (-CD11b)\u7ec44\u4e2a\u6837\u672c\uff0cCTL + ABT263\u7ec44\u4e2a\u6837\u672c\uff0cCTL + ABT263 (-CD11b)\u7ec44\u4e2a\u6837\u672c\uff0cTBI\u7ec411\u4e2a\u6837\u672c\uff0cTBI (-CD11b)\u7ec45\u4e2a\u6837\u672c\uff0cTBI + ABT263\u7ec410\u4e2a\u6837\u672c\uff0cTBI + ABT263 (-CD11b)\u7ec45\u4e2a\u6837\u672c\u3002\u91c7\u7528\u666e\u901a\u5355\u5411ANOVA\u5206\u6790\u5e76\u8fdb\u884cTukey\u6821\u6b63\u3002\u6570\u636e\u4ee5\u5747\u503c \u00b1 SEM\u663e\u793a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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a <\/strong>\u5b9e\u9a8c\u793a\u610f\u56fe\u3002\u7b80\u8981\u6765\u8bf4\uff0cp16-3MR\u5c0f\u9f20\u5728\u6bcf\u4fa7\u80c1\u90e8\u6ce8\u5c04\u4e865 \u00d7 10^5\u4e2a\u8868\u8fbemPlum\u8367\u5149\u86cb\u767d\u7684MC38\u80bf\u7624\u7ec6\u80de\u3002\u5c0f\u9f20\u5728\u7b2c7\u300111\u548c15\u5929\u901a\u8fc7\u8179\u8154\u6ce8\u5c04\u63a5\u53d7\u03b1Ly6c\u963b\u65ad\u6297\u4f53\uff0c\u5e76\u5728\u7b2c9\u548c12\u5929\u63a5\u53d7\u03b1PD-L1\u963b\u65ad\u6297\u4f53\u3002<\/p>\n

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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

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\u2014 THE  END \u2014<\/span><\/section>\n
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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u524d\u671f\u7cbe\u5f69\u5185\u5bb9\uff1a Cancer Cell\uff1a\u901a\u8fc7mRNA\u6280\u672f\u7f16\u7801\u6301\u4e45\u6027IL-2\u5728MHC I\u7c7b\u5206\u5b50\u7f3a\u9677\u764c\u75c7\u4e2d\u53ef\u6062\u590d\u9488…<\/p>\n","protected":false},"author":1,"featured_media":3427,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[63],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3434"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3434"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3434\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3427"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3434"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3434"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3434"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}