{"id":3467,"date":"2024-07-16T10:32:12","date_gmt":"2024-07-16T02:32:12","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2024\/07\/16\/nature%e6%9c%80%e6%96%b0%e9%87%8d%e7%a3%85%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%99%8c%e7%bb%86%e8%83%9e%e4%bb%a3%e8%b0%a2%e4%b8%8e%e6%8a%97%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab\/"},"modified":"2024-07-16T10:32:12","modified_gmt":"2024-07-16T02:32:12","slug":"nature%e6%9c%80%e6%96%b0%e9%87%8d%e7%a3%85%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%99%8c%e7%bb%86%e8%83%9e%e4%bb%a3%e8%b0%a2%e4%b8%8e%e6%8a%97%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2024\/07\/16\/nature%e6%9c%80%e6%96%b0%e9%87%8d%e7%a3%85%e7%bb%bc%e8%bf%b0%ef%bc%9a%e7%99%8c%e7%bb%86%e8%83%9e%e4%bb%a3%e8%b0%a2%e4%b8%8e%e6%8a%97%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab\/","title":{"rendered":"Nature\u6700\u65b0\u91cd\u78c5\u7efc\u8ff0\uff1a\u764c\u7ec6\u80de\u4ee3\u8c22\u4e0e\u6297\u80bf\u7624\u514d\u75ab"},"content":{"rendered":"<div 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wrap;\"><strong>1.\u6458\u8981<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 2;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>2.\u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u764c\u75c7\u4ee3\u8c22\u5b66\u7684\u7814\u7a76\u8d77\u6e90\u4e8e\u4e00\u4e2a\u4e16\u7eaa\u524d\uff0c\u5f53\u5fb7\u56fd\u751f\u7406\u5b66\u5bb6\u5965\u6258\u00b7H\u00b7\u74e6\u5c14\u5821\u53d1\u73b0\u6076\u6027\u7ec6\u80de\u6bd4\u6b63\u5e38\u7ec6\u80de\u6444\u53d6\u66f4\u591a\u7684\u8461\u8404\u7cd6\u3002\u7814\u7a76\u8868\u660e\uff0c\u6076\u6027\u8f6c\u5316\u548c\u80bf\u7624\u8fdb\u5c55\u6d89\u53ca\u5168\u7ec6\u80de\u8303\u56f4\u7684\u4ee3\u8c22\u91cd\u7f16\uff0c\u8fd9\u4e0d\u4ec5\u4ec5\u5c40\u9650\u4e8e\u6240\u8c13\u7684\u201c\u74e6\u5c14\u5821\u6548\u5e94\u201d\uff0c\u800c\u662f\u5305\u62ec\u4e86\u6c27\u5316\u78f7\u9178\u5316\u3001\u4e09\u7fa7\u9178\u5faa\u73af\u3001\u591a\u79cd\u751f\u7269\u5408\u6210\u9014\u5f84\u548c\u5168\u7403\u6027\u5206\u89e3\u4ee3\u8c22\u9014\u5f84\uff0c\u5982\u81ea\u566c\u3002\u8fd9\u4e9b\u53d8\u5316\u4e0d\u4ec5\u9650\u4e8e\u764c\u7ec6\u80de\uff0c\u8fd8\u6d89\u53ca\u5230\u80bf\u7624\u5fae\u73af\u5883\uff0c\u4e3a\u764c\u7ec6\u80de\u63d0\u4f9b\u4e86\u5fc5\u9700\u7684\u4ee3\u8c22\u5e95\u7269\uff0c\u5982\u6838\u82f7\u9178\u3001\u8102\u8d28\u548c\u6c28\u57fa\u9178(<strong>Box 1<\/strong>)\u3002\u6b64\u5916\uff0c\u51e0\u4e4e\u6240\u6709\u764c\u7ec6\u80de\u7684\u4ee3\u8c22\u91cd\u7f16\u90fd\u8d4b\u4e88\u5b83\u4eec\u5728\u4e0d\u65ad\u53d8\u5316\u7684\u5fae\u73af\u5883\u4e2d\u751f\u5b58\u7684\u80fd\u529b\uff0c\u4ece\u800c\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u591a\u6837\u5316\u548c\u6f14\u53d8\u3002\u5df2\u6709\u6570\u636e\u663e\u793a\uff0c\u764c\u7ec6\u80de\u7684\u4ee3\u8c22\u53d8\u5316\u4e5f\u80fd\u5e2e\u52a9\u5b83\u4eec\u9003\u907f\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u76d1\u89c6\u548c\u6740\u4f24\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">Box 1: \u764c\u7ec6\u80de\u4ee3\u8c22\u5bf9\u80bf\u7624\u95f4\u8d28\u7684\u5f71\u54cd<\/span><\/p>\n<p style=\"text-wrap: 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T\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u7f3a\u6c27\u662f\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u6291\u5236\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>4.\u8102\u8d28\u4ee3\u8c22<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u764c\u7ec6\u80de\u7684\u589e\u6b96\u663e\u8457\u4f9d\u8d56\u4e8e\u8102\u8d28\u4ee3\u8c22\u7684\u589e\u5f3a\uff0c\u4e0d\u4ec5\u4e3a\u8102\u80aa\u9178\u6c27\u5316\uff08FAO\uff09\u9a71\u52a8\u7684\u6c27\u5316\u78f7\u9178\u5316\uff08OXPHOS\uff09\u63d0\u4f9b\u989d\u5916\u80fd\u6e90\uff0c\u8fd8\u4f5c\u4e3a\u7ec6\u80de\u819c\u548c\u5176\u4ed6\u8102\u8d28\u5408\u6210\u7684\u6765\u6e90\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u764c\u75c7\u76f8\u5173\u7684FAO\u548c\u8102\u80aa\u9178\u5408\u6210\u7684\u6539\u53d8\u4f1a\u5f71\u54cd\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff08<strong>\u56fe2<\/strong>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-imgfileid=\"308773818\" data-ratio=\"0.49166666666666664\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-e78dadf16be552807272d331e707718c.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p><span style=\"color: rgb(203, 47, 21);\">\u56fe2&nbsp;<\/span>\u8102\u80aa\u9178\u548c\u7c7b\u82b1\u751f\u9178\u4ee3\u8c22\u5bf9\u6297\u764c\u514d\u75ab\u7684\u5f71\u54cd\u3002\u764c\u7ec6\u80de\u901a\u5e38\u4ece\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u6444\u53d6\u66f4\u591a\u7684\u8102\u80aa\u9178\uff0c\u5e76\u901a\u8fc7\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u589e\u52a0\u5185\u6e90\u6027\u8102\u80aa\u9178\u7684\u5408\u6210\u3002\u8fd9\u4f1a\u5bfc\u81f4\u591a\u79cd\u514d\u75ab\u8c03\u8282\u6548\u5e94\u3002\u589e\u52a0\u764c\u7ec6\u80de\u8868\u9762MHC 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style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">4.1 \u8102\u80aa\u9178\u6c27\u5316\uff08FAO\uff09<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">FAO\u901a\u8fc7\u5c06\u957f\u94fe\u8102\u80aa\u9178\u5206\u89e3\u4e3a\u4e59\u9170\u8f85\u9176A\uff0c\u4e3a\u4e09\u7fa7\u9178\u5faa\u73af\uff08TCA\u5faa\u73af\uff09\u63d0\u4f9b\u5e95\u7269\u4ee5\u9a71\u52a8OXPHOS\u3002\u591a\u79cd\u764c\u75c7\u7c7b\u578b\uff08\u5982\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff0cGBM\uff09\u8868\u73b0\u51faFAO\u7387\u7684\u589e\u52a0\uff0c\u652f\u6301\u4e86\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u5728GBM\u4e2d\uff0c\u591a\u79cd\u4e0eFAO\u76f8\u5173\u7684\u9176\u5982\u8089\u6bd2\u78b1\u68d5\u6988\u9170\u8f6c\u79fb\u91761A\uff08CPT1A\uff09\u3001CPT2\u548c\u9170\u8f85\u9176A\u8131\u6c22\u9176\u5bb6\u65cf\u6210\u54589\uff08ACAD9\uff09\u7684\u4e0a\u8c03\uff0c\u4f34\u968f\u7740\u7ec6\u80de\u819c\u4e0a\u201c\u4e0d\u5403\u6211\u201d\u4fe1\u53f7CD47\u7684\u589e\u52a0\uff0c\u6291\u5236\u4e86\u9ad3\u7cfb\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\u5e76\u589e\u5f3a\u4e86\u653e\u5c04\u6297\u6027\u3002\u8fd9\u53cd\u6620\u4e86FAO\u884d\u751f\u7684\u4e59\u9170\u8f85\u9176A\u9a71\u52a8\u7684\u6297\u51cb\u4ea1NF-\u03baB\u4fe1\u53f7\u3002\u8054\u5408\u4f7f\u7528\u653e\u7597\u3001CPT1\u6291\u5236\u5242\u548cCD47\u963b\u65ad\u5242\u5728GBM\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u6bd4\u5355\u72ec\u653e\u7597\u66f4\u597d\u7684\u80bf\u7624\u63a7\u5236\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e59\u9170\u8f85\u9176A\u4e5f\u662f\u81ea\u566c\u7684\u5f3a\u6548\u6291\u5236\u5242\uff0c\u81ea\u566c\u5177\u6709\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u6d3b\u6027\uff0c\u53ef\u80fd\u5728FAO\u7684\u514d\u75ab\u6548\u5e94\u4e2d\u53d1\u6325\u4f5c\u7528(<strong>Box 3<\/strong>)\u3002CPT1A\u7684\u8868\u8fbe\u8fd8\u901a\u8fc7\u4fc3\u8fdb\u6297\u51cb\u4ea1\u4fe1\u53f7\uff0c\u4f7f\u764c\u7ec6\u80de\u5bf9CTL\u884d\u751f\u7684IFN\u03b3\u5177\u6709\u6297\u6027\uff0c\u81f3\u5c11\u5728\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624B16\u548c\u5c0f\u9f20\u524d\u5217\u817a\u764cRM1\u7ec6\u80de\u4e2d\u662f\u5982\u6b64\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e0eFAO\u7684\u514d\u75ab\u6291\u5236\u6548\u5e94\u76f8\u77db\u76fe\uff0c\u6709\u62a5\u9053\u79f0\uff0c\u4ece\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e2d\u5220\u9664\u4e0eFAO\u76f8\u5173\u7684\u57fa\u56e0\u4e59\u9170\u8f85\u9176A\u4e59\u9170\u8f6c\u79fb\u91761\uff08Acat1\uff09\u4f1a\u635f\u5bb3\u514d\u75ab\u8bc6\u522b\u548c\u80bf\u7624\u6e05\u9664\uff0c\u90e8\u5206\u539f\u56e0\u662f\u764c\u7ec6\u80de\u8868\u9762MHC I\u7c7b\u5206\u5b50\u8868\u8fbe\u7684\u51cf\u5c11\u4ee5\u53caTME\u4e2dT\u7ec6\u80de\u6d3b\u5316\u7684\u51cf\u5c11\u3002\u8fd9\u53ef\u80fd\u53cd\u6620\u4e86ACAT1\u5728\u80c6\u56fa\u9187\u916f\u5316\u4e2d\u7684\u4f5c\u7528\uff0c\u53ef\u80fd\u5f71\u54cd\u4e0eMHC\u5206\u5b50\u76f8\u5173\u7684\u7ec6\u80de\u819c\u8102\u7b4f\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u6570\u636e\u5b58\u5728\u77db\u76fe\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\u7814\u7a76\u8868\u660e\uff0c\u8102\u8d28\u4ee3\u8c22\u548cOXPHOS\u5728\u5bf9PD1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53cd\u5e94\u826f\u597d\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u88ab\u5bcc\u96c6\u3002\u8fd9\u4e9b\u89c2\u5bdf\u662f\u5426\u9002\u7528\u4e8e\u5176\u4ed6\u80bf\u7624\u7c7b\u578b\u8fd8\u6709\u5f85\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7531ADP\u6838\u7cd6\u57fa\u5316\u56e0\u5b501\uff08ARF1\uff09\u4ecb\u5bfc\u7684FAO\u4e0a\u6e38\u7684\u8102\u8d28\u52a8\u5458\u4e0e\u764c\u5e72\u7ec6\u80de\u7684\u5f3a\u5927\u514d\u75ab\u9003\u9038\u5c5e\u6027\u76f8\u5173\u3002\u5728\u9057\u4f20\u5de5\u7a0b\u7684\u7ed3\u76f4\u80a0\u764c\u6a21\u578b\u4e2d\u5220\u9664Arf1\u663e\u8457\u51cf\u6162\u4e86\u75be\u75c5\u7684\u53d1\u75c5\u548c\u8fdb\u5c55\uff0c\u6fc0\u6d3b\u4e86\u514d\u75ab\u539f\u6027\u538b\u529b\u548c\u764c\u5e72\u7ec6\u80de\u533a\u57df\u7684\u7ec6\u80de\u6b7b\u4ea1\u9014\u5f84\uff0c\u8fdb\u800c\u6fc0\u6d3b\u4e86\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u4f9d\u8d56\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\uff0cFAO\u5728\u764c\u7ec6\u80de\u4e2d\u5bf9\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u514d\u75ab\u73af\u5883\u7ed3\u6784\u548c\u764c\u75c7\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u654f\u611f\u6027\u6709\u91cd\u8981\u5f71\u54cd\u3002\u8102\u8d28\u4ee3\u8c22\u7684\u6539\u53d8\u4e0d\u4ec5\u5f71\u54cd\u764c\u7ec6\u80de\u7684\u80fd\u91cf\u4f9b\u5e94\u548c\u5408\u6210\u9700\u6c42\uff0c\u8fd8\u663e\u8457\u8c03\u8282\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u548c\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">Box 3: \u764c\u7ec6\u80de\u7684\u81ea\u566c\u53cd\u5e94\u548c\u6297\u80bf\u7624\u514d\u75ab<\/span><\/p>\n<p style=\"text-wrap: wrap;\">\u81ea\u566c\u662f\u4e00\u79cd\u4f9d\u8d56\u6eb6\u9176\u4f53\u7684\u5206\u89e3\u4ee3\u8c22\u8fc7\u7a0b\uff0c\u7528\u4e8e\u5904\u7406\u6f5c\u5728\u7684\u7ec6\u80de\u6bd2\u6027\u548c\/\u6216\u529f\u80fd\u969c\u788d\u7684\u7ec6\u80de\u8d28\u6210\u5206\uff08\u5982\u53d7\u635f\u7684\u7ebf\u7c92\u4f53\uff09\u3002\u81ea\u566c\u5728\u6240\u6709\u6709\u6838\u7ec6\u80de\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u7a33\u6001\u548c\u4ee3\u8c22\u529f\u80fd\uff0c\u4ece\u800c\u652f\u6301\u8bb8\u591a\u514d\u75ab\u7ec6\u80de\u7684\u5206\u5316\u548c\u529f\u80fd\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8868\u660e\uff0c\u6076\u6027\u7ec6\u80de\u4e2d\u7684\u81ea\u7136\u548c\u6cbb\u7597\u8bf1\u5bfc\u7684\u81ea\u566c\u53cd\u5e94\u53ef\u4ee5\u901a\u8fc7\u591a\u79cd\u60c5\u5883\u4f9d\u8d56\u673a\u5236\u5f71\u54cd\u9776\u5411\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002\u4e00\u65b9\u9762\uff0c\u514d\u75ab\u539f\u6027\u5316\u7597\u9a71\u52a8\u7684\u81ea\u566c\u53cd\u5e94\u88ab\u8bc1\u660e\u662f\u6b7b\u4ea1\u7ec6\u80de\u6700\u4f73\u91ca\u653eATP\u6240\u9700\uff0c\u8fd9\u534f\u8c03\u4e86\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u52df\u96c6\u548c\u6d3b\u5316\uff0c\u5e76\u6700\u7ec8\u4fc3\u8fdbCD8+\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u4f9d\u8d56\u7684\u6297\u764c\u514d\u75ab\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u81ea\u566c\u4e5f\u88ab\u62a5\u9053\u5177\u6709\u5f3a\u5927\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u5305\u62ec\u6291\u5236I\u578b\u5e72\u6270\u7d20\u53cd\u5e94\uff0c\u4f8b\u5982\u5728\u6076\u6027\u7ec6\u80de\u4e2d\u7531\u653e\u7597\u8bf1\u53d1\uff0c\u6216\u5728\u9ad8\u7a81\u53d8\u8d1f\u8377\u7684\u80bf\u7624\u4e2d\u81ea\u53d1\u9a71\u52a8\uff0c\u5bfc\u81f4\u8c03\u8282\u6027T\u7ec6\u80de\u4f18\u5148\u6d78\u6da6\u80bf\u7624\u5e76\u4f34\u968fCTL\u8017\u7aed\u3002\u6b64\u5916\uff0c\u81ea\u566c\u8fd8\u53ef\u4ee5\u6291\u5236\u764c\u7ec6\u80de\u8868\u9762MHC I\u7c7b\u5206\u5b50\u7684\u66b4\u9732\uff0c\u964d\u4f4e\u5176\u6297\u539f\u6027\uff0c\u4ee5\u53ca\u964d\u89e3\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u4ea7\u751f\u7684\u9897\u7c92\u9176B\uff0c\u4ece\u800c\u964d\u4f4e\u5bf9\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7684\u654f\u611f\u6027\u3002\u56e0\u6b64\uff0c\u6076\u6027\u7ec6\u80de\u7684\u81ea\u566c\u53cd\u5e94\u662f\u6297\u764c\u514d\u75ab\u5404\u65b9\u9762\u7684\u6838\u5fc3\u8c03\u8282\u56e0\u7d20\u3002\u7136\u800c\uff0c\u81ea\u566c\u8c03\u8282\u5242\u7684\u5f00\u53d1\u9762\u4e34\u591a\u9879\u5c1a\u672a\u89e3\u51b3\u7684\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">4.2 \u8102\u8d28\u5408\u6210<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u8102\u80aa\u9178\u5408\u9176\uff08FASN\uff09\u662f\u65b0\u751f\u8102\u8d28\u751f\u7269\u5408\u6210\u7684\u9650\u901f\u9176\uff0c\u5176\u8868\u8fbe\u6c34\u5e73\u901a\u5e38\u4e0e\u764c\u75c7\u7684\u665a\u671f\u9636\u6bb5\u548c\u8f6c\u79fb\u6027\u6269\u6563\u76f8\u5173\u3002\u5728\u5375\u5de2\u764c\u60a3\u8005\u4e2d\uff0c\u9ad8\u6c34\u5e73\u7684FASN\u4e0e\u80bf\u7624\u4e2dT\u7ec6\u80de\u6d78\u6da6\u7684\u51cf\u5c11\u76f8\u5173\u3002\u8fd9\u4e0d\u4ec5\u662f\u7531\u4e8eCD36\u4f9d\u8d56\u7684T\u7ec6\u80de\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u79ef\u7d2f\u7684\u8102\u80aa\u9178\u7684\u76f4\u63a5\u5438\u6536\u5bfc\u81f4\u7684T\u7ec6\u80de\u6291\u5236\uff0c\u8fd8\u5305\u62ec\u7531\u4e8e\u8102\u8d28\u9a71\u52a8\u7684T\u7ec6\u80de\u4ea4\u53c9\u5448\u9012\u7f3a\u9677\u7531\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u4ecb\u5bfc\uff0c\u4ee5\u53ca\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u529f\u80fd\u3002\u4e0eCD36\u4ecb\u5bfc\u7684\u8102\u80aa\u9178\u5438\u6536\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u76f8\u7b26\uff0c\u80bf\u7624\u4e2d\u8868\u8fbeCD36\u7684CD8+ T\u7ec6\u80de\u6d78\u6da6\u4e0e\u63a5\u53d7\u514d\u75ab\u539f\u6027\u5316\u7597\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e0d\u826f\u75be\u75c5\u9884\u540e\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">4.3 \u82b1\u751f\u56db\u70ef\u9178\u5408\u6210<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u589e\u52a0\u7684FASN\u6d3b\u6027\u8fd8\u4fc3\u8fdb\u4e86\u4e0e\u524d\u5217\u817a\u7d20\u5185\u8fc7\u6c27\u5316\u7269\u5408\u91762\uff08PTGS2\uff1b\u66f4\u5e7f\u4e3a\u4eba\u77e5\u7684\u540d\u79f0\u662f\u73af\u6c27\u5316\u91762\uff08COX2\uff09\uff09\u76f8\u5173\u7684\u7ec6\u80de\u5185\u8102\u6ef4\u7684\u79ef\u7d2f\uff0c\u8fd9\u662f\u5408\u6210\u5305\u62ec\u524d\u5217\u817a\u7d20E2\uff08PGE2\uff09\u5728\u5185\u7684\u82b1\u751f\u56db\u70ef\u9178\u7684\u5173\u952e\u9176\u3002PGE2\u5bf9\u6076\u6027\u7ec6\u80de\u5177\u6709\u76f4\u63a5\u7684\u4fc3\u5206\u88c2\u4f5c\u7528\uff0c\u540c\u65f6\u5177\u6709\u591a\u79cd\u514d\u75ab\u6291\u5236\u6548\u679c\u3002\u8fd9\u4e9b\u5305\u62ec\u7531\u4e8e\u524d\u5217\u817a\u7d20E\u53d7\u4f532\uff08PTGER2\uff09\u548cPTGER4\u4fe1\u53f7\u4f20\u5bfc\u53ca\u7ec6\u80de\u5185\u73af\u78f7\u9178\u817a\u82f7\u6c34\u5e73\u7684\u589e\u52a0\u5f15\u8d77\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff0c\u6291\u5236\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u5206\u6ccc\u6d3b\u6027\uff08\u8fd9\u4e5f\u5f71\u54cd\u5230\u4ea4\u53c9\u5448\u9012\u6297\u539f\u7ed9T\u7ec6\u80de\u6240\u9700\u76841\u578b\u5e38\u89c4DCs\u7684\u62db\u52df\uff09\uff0c\u4ee5\u53ca\u901a\u8fc7NF-\u03baB\u4ecb\u5bfc\u7684PD1\u4e0a\u8c03\u5bfc\u81f4\u7684T\u7ec6\u80de\u6291\u5236\uff0c\u8fd9\u4e00\u6548\u5e94\u88abPGE2\u4e0a\u8c03\u9ad3\u7cfb\u7ec6\u80de\u4e0a\u7684PDL1\u8868\u8fbe\u7684\u80fd\u529b\u52a0\u5267\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">PGE2\u8fd8\u5728\u9ad3\u7cfb\u7ec6\u80de\u4e0a\u5916\u819c\u6838\u82f7\u9178\u9176CD73\u7684\u4e0a\u8c03\u65b9\u9762\u4e0e\u7f3a\u6c27\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u76f8\u4f3c\uff0c\u8fd9\u6709\u52a9\u4e8e\u514d\u75ab\u6291\u5236\u7684\u6838\u82f7\u9178\u4ee3\u8c22\u6548\u5e94(<strong>Box 2<\/strong>)\u3002\u6709\u8da3\u7684\u662f\uff0c\u78f7\u8102\u9170\u80c6\u78b1\u8f6c\u8fd0\u86cb\u767dMFSD2A\u5df2\u88ab\u663e\u793a\u4e3a\u5728\u4eba\u7c7b\u548c\u5c0f\u9f20\u80c3\u764c\u7ec6\u80de\u4e2d\u4f5c\u4e3a\u5185\u6e90\u6027COX2\u6291\u5236\u5242\uff0c\u51cf\u5c11PGE2\u548c\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50TGF\u03b21\u7684\u751f\u4ea7\u548c\u91ca\u653e\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6076\u6027\u7ec6\u80de\u8fc7\u8868\u8fbeMFSD2A\u5df2\u88ab\u663e\u793a\u4e3a\u7ed5\u8fc7PD1\u963b\u65ad\u7684\u6297\u6027\uff0c\u5e76\u4e0eTME\u4e2d\u6539\u5584\u7684CD8+ CTL\u53cd\u5e94\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u8fd9\u4e9b\u89c2\u5bdf\u7a81\u51fa\u663e\u793a\u4e86\u8102\u80aa\u9178\u4ee3\u8c22\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u529f\u80fd\u4e4b\u95f4\u7684\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u3002\u66f4\u597d\u5730\u7406\u89e3\u8fd9\u4e9b\u673a\u5236\u5c06\u4e3a\u5f00\u53d1\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u5b9d\u8d35\u7684\u89c1\u89e3\uff0c\u4ee5\u63d0\u9ad8\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: flex;flex-flow: row;margin: 20px 0% 10px;text-align: left;justify-content: flex-start;\">\n<section style=\"display: inline-block;vertical-align: middle;width: 15%;align-self: center;background-color: rgb(49, 116, 161);flex: 0 0 auto;height: auto;border-width: 0px;line-height: 1.4;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: middle;width: auto;align-self: center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>5.\u5176\u4ed6\u4ee3\u8c22\u9014\u5f84<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u6076\u6027\u8f6c\u5316\u8fc7\u7a0b\u4e2d\uff0c\u5176\u4ed6\u4ee3\u8c22\u9014\u5f84\u7684\u53d8\u5316\u4e5f\u4f1a\u5f71\u54cd\u6297\u764c\u514d\u75ab\u76d1\u89c6\u3002\u8fd9\u4e9b\u9014\u5f84\u5305\u62ec\uff08\u4f46\u4e0d\u9650\u4e8e\uff09\u6838\u82f7\u9178\u548c\u5404\u79cd\u6c28\u57fa\u9178\u7684\u4ee3\u8c22\uff08<strong>\u56fe3<\/strong>\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-imgfileid=\"308773819\" data-ratio=\"0.4648148148148148\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1080\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-c2ca357789fae8564c286a53366208e5.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p><span style=\"color: rgb(203, 47, 21);\">\u56fe3&nbsp;<\/span>\u6838\u82f7\u9178\u548c\u6c28\u57fa\u9178\u4ee3\u8c22\u5bf9\u6297\u764c\u514d\u75ab\u7684\u5f71\u54cd\u3002a. 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wrap;\">\u4e0e\u6b63\u5e38\u7ec6\u80de\u76f8\u6bd4\uff0c\u764c\u7ec6\u80de\u7684\u6838\u82f7\u9178\u5408\u6210\u589e\u52a0\uff0c\u8fd9\u5bf9\u6297\u764c\u514d\u75ab\u6709\u663e\u8457\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u764c\u7ec6\u80de\u4e2d\u5c3f\u7d20\u5faa\u73af\u9176\u7684\u6539\u53d8\u5bfc\u81f4\u5c3f\u7d20\u5faa\u73af\u5931\u8c03\uff08UCD\uff09\uff0c\u5c06\u6c2e\u6d41\u8f6c\u5411\u78b3\u9170\u78f7\u9178\u5408\u6210\u91762\u3001\u5929\u51ac\u6c28\u9178\u8f6c\u6c28\u9176\u548c\u4e8c\u6c22\u4e73\u6e05\u9178\u8131\u6c22\u9176\uff08CAD\uff09\uff0c\u5bfc\u81f4\u5627\u5576\u5408\u6210\u8fc7\u5269\u3002\u8fd9\u6837\u7684\u6539\u53d8\u4fc3\u8fdb\u4e86\u4e00\u79cd\u72ec\u7279\u7684\u57fa\u56e0\u7ec4\u7279\u5f81\uff0c\u5176\u7279\u5f81\u662f\u560c\u5464\u5230\u5627\u5576\u7684\u6613\u4f4d\uff0c\u5e76\u4e0e\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u654f\u611f\u6027\u589e\u52a0\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">ATP\u7684\u8fd9\u79cd\u514d\u75ab\u523a\u6fc0\u6548\u5e94\u88ab\u7ec6\u80de\u5916\u6838\u82f7\u9178\u9176CD39\u548cCD73\u7684\u6d3b\u6027\u964d\u89e3\uff0c\u4e8c\u8005\u5171\u540c\u4fc3\u8fdb\u817a\u82f7\u7684\u751f\u6210\uff0c\u817a\u82f7\u662f\u4e00\u79cd\u5f3a\u6548\u7684\u514d\u75ab\u6291\u5236\u5206\u5b50\u3002\u56e0\u6b64\uff0c\u80bf\u7624\u5185CD39\u548cCD73\u7684\u6c34\u5e73\uff08\u5728\u4e0d\u540c\u80bf\u7624\u548c\u540c\u4e00\u80bf\u7624\u7684\u4e0d\u540c\u533a\u57df\u8868\u73b0\u51fa\u663e\u8457\u5dee\u5f02\uff09\u51b3\u5b9a\u4e86\u7ec6\u80de\u5916ATP\u514d\u75ab\u523a\u6fc0\uff08CD39\u548cCD73\u8868\u8fbe\u4f4e\uff09\u4e0e\u514d\u75ab\u6291\u5236\uff08CD39\u548cCD73\u8868\u8fbe\u9ad8\uff09\u7684\u5e73\u8861\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 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style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u901a\u8fc7\u5728TME\u4e2d\u4f18\u5148\u6fc0\u6d3b\u7684\u524d\u836f\uff08JHU083\uff09\u836f\u7406\u6291\u5236GLS\uff0c\u53ef\u4ee5\u6291\u5236\u764c\u7ec6\u80de\u4e2d\u7684\u6c27\u5316\u548c\u7cd6\u9175\u89e3\u4ee3\u8c22\uff0c\u540c\u65f6\u4fc3\u8fdbCTLs\u4e2d\u7684\u6c27\u5316\u78f7\u9178\u5316\uff08OXPHOS\uff09\uff0c\u4ece\u800c\u8bf1\u5bfc\u6301\u4e45\u6d3b\u5316\u7684\u8868\u578b\u3002\u8fd9\u5728\u643a\u5e26MC38\u7ed3\u76f4\u80a0\u764c\u7684\u5c0f\u9f20\u4e2d\u9a71\u52a8\u4e86\u5f3a\u5927\u7684\u6297\u764c\u53cd\u5e94\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u6709\u6548\u9776\u5411\u764c\u7ec6\u80de\u4e2d\u7684\u8c37\u6c28\u9170\u80fa\u4ee3\u8c22\uff0c\u540c\u65f6\u4fdd\u62a4\u80bf\u7624\u5185CTLs\u7684\u6cbb\u7597\u7b56\u7565\u5177\u6709\u8f83\u9ad8\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u6b64\u5916\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u548c\u7ed3\u76f4\u80a0\u764c\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u6076\u6027\u7ec6\u80de\u901a\u8fc7\u6eb6\u8d28\u8f7d\u4f53SLC38A2\u4e0e1\u578b\u5e38\u89c4\u6811\u7a81\u72b6\u7ec6\u80de\u7ade\u4e89\u80bf\u7624\u5185\u7684\u8c37\u6c28\u9170\u80fa\u53ef\u7528\u6027\u3002\u8fd9\u8868\u660e\u80bf\u7624\u7ec6\u80de\u4e0a\u7684SLC38A2\u662f\u65b0\u578b\u514d\u75ab\u6297\u764c\u836f\u7269\u7684\u6f5c\u5728\u9776\u70b9\u3002\u5728\u4e34\u5e8a\u524d\u9aa8\u8089\u7624\u6a21\u578b\u4e2d\uff0c\u764c\u7ec6\u80de\u901a\u8fc7LAT2\uff08\u4e5f\u79f0\u4e3aSLC7A8\uff09\u589e\u52a0\u7684\u8c37\u6c28\u9170\u80fa\u6444\u53d6\u4e0eCD47\u7684\u4e0a\u8c03\u76f8\u5173\uff0c\u5bfc\u81f4\u541e\u566c\u4f5c\u7528\u53d7\u5230\u6291\u5236\u5e76\u52a0\u901f\u80bf\u7624\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7efc\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u53d1\u73b0\u5c55\u793a\u4e86\u8c37\u6c28\u9170\u80fa\u4ee3\u8c22\u5728\u764c\u75c7\u548c\u514d\u75ab\u7ec6\u80de\u4e2d\u7684\u591a\u79cd\u514d\u75ab\u8c03\u8282\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">5.3 \u7532\u786b\u6c28\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7532\u786b\u6c28\u9178\uff08\u86cb\u6c28\u9178\uff09\u662f\u4e00\u79cd\u5fc5\u9700\u6c28\u57fa\u9178\uff0c\u9664\u4e86\u4fc3\u8fdb\u86cb\u767d\u8d28\u5408\u6210\u5916\uff0c\u8fd8\u53c2\u4e0e\u9176\u4fc3\u7532\u57fa\u5316\u53cd\u5e94\u3002\u5728\u5c0f\u9f20\u548c\u4eba\u7c7b\u809d\u7ec6\u80de\u764c\u6a21\u578b\u4e2d\uff0c\u7532\u786b\u6c28\u9178\u518d\u5faa\u73af\u9176\u53ca\u5176\u4ea7\u7269\uff08\u5305\u62ec5-\u7532\u57fa\u786b\u817a\u82f7\u548cS-\u817a\u82f7\u7532\u786b\u6c28\u9178[SAM]\uff09\u6c34\u5e73\u7684\u589e\u52a0\u4e0eT\u7ec6\u80de\u8017\u7aed\u76f8\u5173\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6572\u9664\u7532\u786b\u6c28\u9178\u817a\u82f7\u8f6c\u79fb\u91762A\uff08Mat2a\uff0c\u8be5\u9176\u5728SAM\u5408\u6210\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\uff09\u6062\u590d\u4e86\u4f53\u5185T\u7ec6\u80de\u6d3b\u5316\u548c\u809d\u7ec6\u80de\u764c\u7684\u63a7\u5236\u3002\u7c7b\u4f3c\u5730\uff0c\u7532\u786b\u6c28\u9178\u5df2\u88ab\u8bc1\u660e\u4ee5\u7532\u57fa\u5316\u4f9d\u8d56\u6027\u65b9\u5f0f\u635f\u5bb3cGAS\u6d3b\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u764c\u7ec6\u80de\u901a\u5e38\u8868\u8fbe\u9ad8\u6c34\u5e73\u7684\u7532\u786b\u6c28\u9178\u8f6c\u8fd0\u4f53LAT4\uff08\u4e5f\u79f0\u4e3aSLC43A2\uff09\uff0c\u4ece\u800c\u4e0eT\u7ec6\u80de\u7ade\u4e89\u8fd9\u79cd\u5fc5\u9700\u6c28\u57fa\u9178\u3002\u8fd9\u5bfc\u81f4T\u7ec6\u80de\u4e2d\u4e8c\u7532\u57fa\u5316\u7ec4\u86cb\u767dH3\u8d56\u6c28\u917879\uff08H3K79me2\uff09\u7684\u4e27\u5931\uff0c\u51cf\u5c11\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b505A\uff08STAT5A\uff09\u4fe1\u53f7\u4f20\u5bfc\uff0c\u5e76\u6291\u5236T\u7ec6\u80de\u529f\u80fd\u3002\u5728\u643a\u5e26\u7ed3\u76f4\u80a0\u764c\u7684\u5c0f\u9f20\u4e2d\uff0c\u6291\u5236LAT4\u548c\u8865\u5145\u7532\u786b\u6c28\u9178\u5747\u53ef\u514b\u670d\u8fd9\u4e00\u7f3a\u9677\u5e76\u6062\u590d\u6297\u764c\u514d\u75ab\u3002\u80bf\u7624\u7279\u5f02\u6027LAT4\u6291\u5236\u8054\u5408cGAS-STING1\u6fc0\u6d3b\uff08\u901a\u8fc7\u643a\u5e26\u9776\u5411slc43a2\u7684CRISPR-Cas9\u6784\u5efa\u7269\u548cZn2+\u79bb\u5b50\u7684\u53cc\u91d1\u5c5e\u7eb3\u7c73\u5e73\u53f0\u5b9e\u73b0\uff09\u5728\u4e34\u5e8a\u524dTNBC\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u6709\u524d\u666f\u7684\u514d\u75ab\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u8fd9\u4e9b\u4f8b\u5b50\u8868\u660e\uff0cLAT4\u662f\u5f00\u53d1\u65b0\u578b\u514d\u75ab\u523a\u6fc0\u5242\u7684\u6f5c\u5728\u9776\u70b9\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u5fc5\u987b\u8bbe\u60f3\u6709\u9488\u5bf9\u6027\u7684\u65b9\u6cd5\uff0c\u80fd\u591f\u4ece\u764c\u7ec6\u80de\u4e2d\u9009\u62e9\u6027\u5730\u6d88\u8017\u7532\u786b\u6c28\u9178\uff0c\u800c\u4e0d\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u7532\u786b\u6c28\u9178\u6444\u53d6\uff0c\u56e0\u4e3a\u514d\u75ab\u7ec6\u80de\u7684\u6297\u764c\u529f\u80fd\u4e5f\u4f9d\u8d56\u4e8e\u7532\u786b\u6c28\u9178\u7684\u6444\u53d6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">5.4 \u8272\u6c28\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7531\u9176IDO1\u548c\u8272\u6c28\u91782,3-\u53cc\u52a0\u6c27\u9176\uff08TDO\uff09\u542f\u52a8\u7684\u8272\u6c28\u9178\u5206\u89e3\u4ee3\u8c22\u5f15\u8d77\u4e86\u76f8\u5f53\u5927\u7684\u5173\u6ce8\uff0c\u4f5c\u4e3a\u5f00\u53d1\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u7684\u6f5c\u5728\u9776\u70b9\u3002\u5728\u4e00\u4e9b\u6076\u6027\u7ec6\u80de\u548c\u8010\u53d7\u6027\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u4e2d\uff0cIDO1\u7684\u8fc7\u5ea6\u6d3b\u5316\u5bfc\u81f4\u4e86\u5e7f\u6cdb\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u8fd9\u4e3b\u8981\u662f\u7531\u4e8e\u72ac\u5c3f\u6c28\u9178\u7684\u79ef\u7d2f\u3002\u72ac\u5c3f\u6c28\u9178\u80fd\u6709\u6548\u6291\u5236T\u7ec6\u80de\u5e76\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u5206\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5c3d\u7ba1\u8272\u6c28\u9178\u662f\u4e00\u79cd\u5fc5\u9700\u6c28\u57fa\u9178\uff0c\u4f46\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684\u6d53\u5ea6\u5e76\u672a\u4f4e\u4e8e\u9650\u5236\u9608\u503c\uff0c\u8fd9\u8868\u660e\u8272\u6c28\u9178\u7f3a\u4e4f\u5e76\u4e0d\u662fIDO1\u9a71\u52a8\u7684\u514d\u75ab\u6291\u5236\u7684\u4e3b\u8981\u673a\u5236\u3002IDO1\u901a\u8def\u7684\u5176\u4ed6\u514d\u75ab\u6291\u5236\u4ea7\u7269\u5305\u62ec\u55b9\u5549\u9178\uff0c\u5df2\u88ab\u8bc1\u660e\u5728\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u4e2d\u901a\u8fc7\u4fc3\u8fdbFOXO1\u4e0b\u6e38\u7684M2\u578b\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u6781\u5316\u548c\u8fc7\u6c27\u5316\u7269\u9176\u4f53\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u4f53-\u03b3\u4fe1\u53f7\u901a\u8def\u8d77\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">5.5 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wrap;\">\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5e72\u7ec6\u80de\u5df2\u88ab\u8bc1\u660e\u80fd\u591f\u91cd\u7f16\u7a0b\u8d56\u6c28\u9178\u5206\u89e3\u4ee3\u8c22\uff0c\u5bfc\u81f4\u5df4\u8c46\u9170\u8f85\u9176A\u5728\u7ec6\u80de\u5185\u79ef\u7d2f\uff0c\u8fdb\u800c\u5f15\u8d77\u7ec4\u86cb\u767dH4\u8d56\u6c28\u9178\u7684\u5df4\u8c46\u5316\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6291\u5236\u8d56\u6c28\u9178\u7684\u5df4\u8c46\u5316\u53ef\u589e\u5f3a\u7531\u53cc\u94feRNA\uff08dsRNA\uff09\u548c\u53cc\u94feDNA\uff08dsDNA\uff09\u8bf1\u5bfc\u7684I\u578b\u5e72\u6270\u7d20\u4fe1\u53f7\u4f20\u5bfc\uff0c\u6700\u7ec8\u6062\u590d\u80bf\u7624\u4e2d\u7684CD8+ 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center;border-style: none;border-width: 0px;border-color: rgb(49, 116, 161) rgb(49, 116, 161) rgb(49, 116, 161) rgb(0, 137, 123);flex: 100 100 0%;height: auto;\">\n<section style=\"padding-right: 10px;padding-left: 10px;line-height: 1.5;letter-spacing: 0px;color: rgb(0, 0, 0);font-size: 18px;text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><strong>6.\u9776\u5411\u80bf\u7624\u7ec6\u80de\u4ee3\u8c22<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"line-height: 0;\">\n<section style=\"vertical-align: middle;display: inline-block;line-height: 0;\"><img decoding=\"async\" data-imgfileid=\"308773821\" data-ratio=\"0.8804448563484708\" data-s=\"300,640\"  data-type=\"png\" data-w=\"1079\" style=\"vertical-align: middle;width: 100%;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-436bc5847d662b07c347b40dacb79ef5.png\"  \/><\/section>\n<\/section>\n<section style=\"text-align: right;justify-content: flex-end;margin-right: 0%;margin-bottom: 10px;margin-left: 0%;display: flex;flex-flow: row;\">\n<section style=\"display: inline-block;vertical-align: top;width: 30px;border-left: 2px solid rgb(113, 178, 198);border-bottom-left-radius: 0px;border-bottom: 2px solid rgb(113, 178, 198);border-bottom-right-radius: 0px;flex: 0 0 auto;height: auto;line-height: 1;align-self: flex-start;\">\n<section style=\"text-align: justify;\">\n<p style=\"text-wrap: wrap;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 90%;flex: 0 0 auto;height: auto;padding-left: 8px;align-self: flex-start;\">\n<section style=\"color: rgb(106, 106, 106);font-size: 15px;text-align: left;\">\n<p><span style=\"color: rgb(203, 47, 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\u6700\u5148\u8fdb\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff1bb. \u6839\u636eClinicalTrials.gov\uff0c\u622a\u81f32024\u5e742\u6708\u3002\u6b64\u8868\u683c\u5c55\u793a\u4e86\u9488\u5bf9\u764c\u7ec6\u80de\u4ee3\u8c22\u4ee5\u6062\u590d\u514d\u75ab\u76d1\u89c6\u7684\u4e3b\u8981\u4ee3\u8c22\u6291\u5236\u5242\u53ca\u5176\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u4fe1\u606f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">6.1 \u8461\u8404\u7cd6\u548c\u4e73\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u80f0\u817a\u764c\u548c\u80ba\u764c\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u836f\u7269Bay876\u5bf9GLUT1\u8fdb\u884c\u6291\u5236\uff0c\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u589e\u5f3a\u5bf9PD1\u9776\u5411\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7684\u6cbb\u7597\u53cd\u5e94\u3002\u7136\u800c\uff0cGLUT3\uff08\u4e5f\u79f0\u4e3aSLC2A3\uff09\u7684\u8fc7\u8868\u8fbe\u4f3c\u4e4e\u90e8\u5206\u4ee3\u507f\u4e86GLUT1\u7684\u6291\u5236\uff0c\u8fd9\u63d0\u793a\u8054\u5408\u6291\u5236GLUT1\u548cGLUT3\u53ef\u80fd\u662f\u66f4\u6709\u6548\u7684\u7b56\u7565\u3002\u5728\u9ed1\u8272\u7d20\u7624\u548c\u7ed3\u76f4\u80a0\u764c\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cPD1\u963b\u65ad\u4e0ePKF-015\uff08\u7cd6\u9175\u89e3\u91766-\u78f7\u9178\u679c\u7cd6-2-\u6fc0\u9176\/\u679c\u7cd6-2,6-\u4e8c\u78f7\u9178\u91763 [PFKFB3] 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style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">6.2 \u8c37\u6c28\u9170\u80fa<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u636e\u62a5\u9053\uff0cGLS\u9776\u5411\u836f\u7269Telaglenastat\uff08\u4e5f\u79f0\u4e3aCB-839\uff09\u4e0e\u653e\u7597\u8054\u5408\u4f7f\u7528\u53ef\u4ee5\u534f\u540c\u6cbb\u7597\u4eba\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u548c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u5f02\u79cd\u79fb\u690d\u7624\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695aTelaglenastat\u7684\u653e\u5c04\u589e\u654f\u4f5c\u7528\u662f\u5426\u6d89\u53ca\u56fa\u6709\u514d\u75ab\u6fc0\u6d3b\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5728\u514d\u75ab\u6b63\u5e38\u7684\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\uff0cTelaglenastat\u88ab\u8bc1\u660e\u4e0eCTLA4\u548cPD1\u963b\u6ede\u5242\u6709\u534f\u540c\u4f5c\u7528\uff0c\u8fd9\u8868\u660e\u8be5\u836f\u7269\u786e\u5b9e\u5177\u6709\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u514d\u75ab\u523a\u6fc0\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u51e0\u9879\u72ec\u7acb\u7814\u7a76\u7684\u4e34\u5e8a\u6570\u636e\u8868\u660e\uff0cTelaglenastat\u53ef\u4ee5\u5b89\u5168\u5730\u4e0e\u6807\u51c6\u5316\u7597\u8054\u5408\u4f7f\u7528\uff0c\u4f46\u6cbb\u7597\u83b7\u76ca\u8f83\u5c0f\u3002\u8fd9\u4e9b\u4e34\u5e8a\u53d1\u73b0\u964d\u4f4e\u4e86\u5c06Telaglenastat\u4f5c\u4e3a\u65b0\u578b\u6297\u764c\u836f\u7269\u5f00\u53d1\u7684\u5174\u8da3\uff0c\u622a\u81f32024\u5e742\u6708\uff0c\u53ea\u6709\u4e00\u9879\u9488\u5bf9NSCLC\u60a3\u8005\u7684\u7814\u7a76\u4ecd\u5728\u5f00\u653e\u62db\u52df\uff08ClinicalTrials.gov: NCT03831932\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5229\u75282-\u6c28\u57fa\u53cc\u73af-(2,2,1)-\u5e9a\u70f7-2-\u7fa7\u9178\uff08BCH\uff09\u901a\u8fc7LAT2\u836f\u7406\u6291\u5236\u8c37\u6c28\u9170\u80fa\u6444\u53d6\uff0c\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u589e\u5f3a\u514d\u75ab\u539f\u6027\u5316\u7597\u836f\u7269\u591a\u67d4\u6bd4\u661f\u5bf9\u9aa8\u8089\u7624\u7ec6\u80de\u7684\u6cbb\u7597\u6548\u679c\uff0c\u8fd9\u4e00\u6548\u5e94\u81f3\u5c11\u90e8\u5206\u5f52\u56e0\u4e8eCD47\u4e0b\u8c03\u548c\u764c\u7ec6\u80de\u541e\u566c\u4f5c\u7528\u589e\u52a0\u3002\u540c\u6837\uff0cV-9302\u662f\u4e00\u79cd\u901a\u8fc7\u6eb6\u8d28\u8f7d\u4f53ASCT2\uff08\u4e5f\u79f0\u4e3aSLC1A5\uff09\u6444\u53d6\u8c37\u6c28\u9170\u80fa\u7684\u836f\u7406\u5b66\u6291\u5236\u5242\uff0c\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u88ab\u8bc1\u660e\u80fd\u591f\u4ecb\u5bfcT\u7ec6\u80de\u4f9d\u8d56\u7684\u80bf\u7624\u63a7\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7136\u800c\uff0cV-9302\u5728\u5c0f\u9f20\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u4e2d\u4e5f\u901a\u8fc7NF-\u03baB\u4e0a\u8c03PDL1\uff0c\u6291\u5236\u4e86\u80bf\u7624\u9776\u5411\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u79cd\u514d\u75ab\u6291\u5236\u53cd\u5e94\u4f34\u968f\u7740\u6076\u6027\u7ec6\u80de\u8868\u9762\u6b7b\u4ea1\u53d7\u4f53FAS\uff08\u4e5f\u79f0\u4e3aCD95\uff09\u7684\u4e0a\u8c03\uff0c\u4ece\u800c\u4f7f\u6076\u6027\u7ec6\u80de\u5bf9PDL1\u963b\u6ede\u5242\u91cd\u65b0\u6fc0\u6d3b\u7684T\u7ec6\u80de\u5e94\u7b54\u66f4\u654f\u611f\u3002\u8fd9\u4e9b\u5173\u4e8eV-9302\u5bf9\u6297\u764c\u514d\u75ab\u5f71\u54cd\u7684\u4e0d\u540c\u89c2\u5bdf\u7ed3\u679c\u662f\u5426\u53cd\u6620\u4e86\u4e0d\u540c\u764c\u7ec6\u80de\u7c7b\u578b\u4e2d\u8c37\u6c28\u9170\u80fa\u4ee3\u8c22\u7684\u7279\u5f02\u6027\uff0c\u4ecd\u9700\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">6.3 \u8272\u6c28\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u4e00\u7cfb\u5217\u514d\u75ab\u6b63\u5e38\u7684\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u901a\u8fc7\u836f\u7406\u5b66\u6216\u9057\u4f20\u5b66\u65b9\u6cd5\u963b\u65adIDO1\u548c\/\u6216TDO\u6d3b\u6027\u53ef\u4ee5\u663e\u8457\u589e\u5f3a\u514d\u75ab\u6cbb\u7597\u6548\u679c\uff0c\u5e76\u4e14\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICIs\uff09\u901a\u5e38\u53ef\u4ee5\u653e\u5927\u8fd9\u79cd\u6548\u679c\u3002\u8fd9\u4e9b\u53d1\u73b0\u6fc0\u53d1\u4e86\u5f00\u53d1\u4e34\u5e8a\u4e0a\u53ef\u6d4b\u8bd5\u7684IDO1\u6291\u5236\u5242\uff08\u5982epacadostat\uff09\u7684\u6781\u5927\u5174\u8da3\u3002\u65e9\u671f\u975e\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u521d\u6b65\u7ed3\u679c\u663e\u793a\uff0c\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0cepacadostat\u8054\u5408PD1\u963b\u6ede\u5242\u662f\u5b89\u5168\u4e14\u6709\u6548\u7684\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u9884\u671f\u5f88\u9ad8\uff0c\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u8fdb\u884c\u7684\u4e00\u9879\u968f\u673a\u4e09\u671f\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0cepacadostat\u8054\u5408PD1\u963b\u6ede\u5242\u5e15\u535a\u5229\u73e0\u5355\u6297\u76f8\u6bd4\u4e8e\u5355\u72ec\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ca1\u6709\u663e\u793a\u51fa\u663e\u8457\u7684\u6cbb\u7597\u4f18\u52bf\u3002\u8fd9\u662f\u5426\u53cd\u6620\u4e86\u8272\u6c28\u9178\u66ff\u4ee3\u964d\u89e3\u9014\u5f84\u7684\u5b58\u5728\uff0c\u4ecd\u6709\u5f85\u8bc1\u5b9e\u3002\u8fd9\u4e9b\u66ff\u4ee3\u9014\u5f84\u5df2\u88ab\u8bc1\u660e\u5728\u975e\u80bf\u7624\u6027\u75be\u75c5\uff08\u5c24\u5176\u662f\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff09\u4e2d\u4ecb\u5bfc\u514d\u75ab\u6291\u5236\uff0c\u5e76\u53ef\u80fd\u5728IDO1\u6291\u5236\u7684\u60c5\u51b5\u4e0b\u4e0a\u8c03\u3002\u8fd9\u4e9b\u8d1f\u9762\u7ed3\u679c\u5927\u5927\u964d\u4f4e\u4e86\u5236\u836f\u516c\u53f8\u5bf9\u5f00\u53d1IDO1\u6291\u5236\u5242\u7684\u5174\u8da3\uff0c\u622a\u81f32024\u5e742\u6708\uff0c\u53ea\u6709\u5c11\u6570\u4e34\u5e8a\u8bd5\u9a8c\u4ecd\u5728\u5f00\u653e\u62db\u52df\u3002\u7136\u800c\uff0c\u65b0\u7684IDO1\u9776\u5411\u65b9\u6cd5\uff0c\u5982\u901a\u8fc7\u6291\u5236\u6cdb\u7d20\u7279\u5f02\u6027\u80bd\u917614\uff08USP14\uff09\u7684IU1\uff0c\u5df2\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u6709\u6548\u6062\u590d\u4e86T\u7ec6\u80de\u4f9d\u8d56\u7684\u75be\u75c5\u63a7\u5236\uff0c\u53ef\u80fd\u4f1a\u91cd\u65b0\u6fc0\u53d1\u4eba\u4eec\u7684\u5174\u8da3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">6.4 \u6838\u82f7\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u5404\u79cd\u4e34\u5e8a\u524d\u764c\u75c7\u6a21\u578b\u4e2d\uff0c\u836f\u7406\u5b66\u6291\u5236CD39\u3001CD73\u548c\/\u6216\u817a\u82f7\u53d7\u4f53\u4e0e\u6297\u764c\u514d\u75ab\u6062\u590d\u548c\u75be\u75c5\u63a7\u5236\u6539\u5584\u76f8\u5173\u3002\u636e\u62a5\u9053\uff0c\u9776\u5411CD73\u7684\u5c0f\u5206\u5b50AB680\u53ef\u4ee5\u589e\u5f3a\u5c0f\u9f20\u80f0\u817a\u764c\u5bf9PD1\u7279\u5f02\u6027\u514d\u75ab\u6291\u5236\u5242\u7684\u654f\u611f\u6027\uff0c\u8fd9\u79cd\u6cbb\u7597\u6548\u679c\u4e0eTreg\u7ec6\u80de\u5728\u80bf\u7624\u4e2d\u7684\u51cf\u5c11\u6709\u5173\u3002\u540c\u6837\uff0c\u5728\u4e73\u817a\u764c\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u9776\u5411CD73\u7684\u5355\u514b\u9686\u6297\u4f53\u53ef\u63d0\u9ad8\u5c40\u90e8\u653e\u7597\u8054\u5408CTLA4\u963b\u6ede\u5242\u7684\u7597\u6548\uff0c\u90e8\u5206\u539f\u56e0\u662fDC\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u589e\u52a0\u548c\u6d3b\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u3001\u9ed1\u8272\u7d20\u7624\u548c\u80ba\u764c\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u5c06\u53ef\u5c06\u7ec6\u80de\u5916\u817a\u82f7\u8f6c\u5316\u4e3a\u808c\u82f7\u7684\u805a\u4e59\u4e8c\u9187\u5316\u817a\u82f7\u8131\u6c28\u9176\u4e0ePD1\u963b\u6ede\u5242\u8054\u5408\u5e94\u7528\u4e5f\u663e\u793a\u4e86\u7c7b\u4f3c\u7684\u6548\u679c\u3002\u6700\u540e\uff0c\u817a\u82f7A2a\u53d7\u4f53\uff08ADORA2A\uff09\u62ee\u6297\u5242\u5728\u4e34\u5e8a\u524d\u80bf\u7624\u6a21\u578b\u4e2d\u5df2\u88ab\u8bc1\u660e\u4e0e\u51e0\u79cd\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u6709\u534f\u540c\u4f5c\u7528\uff0c\u5305\u62ec\u767d\u8840\u75c5\u6a21\u578b\u4e2d\u7684CAR T\u7ec6\u80de\u7597\u6cd5\u4ee5\u53ca\u4e73\u817a\u764c\u548c\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\u7684PD1\u963b\u6ede\u5242\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u4e0e\u8fd9\u4e9b\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\uff0c\u591a\u4e2aI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6216\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u8bc4\u4f30\u4e86ADORA2A\u6216ADORA2B\u62ee\u6297\u5242\uff0c\u7ed3\u679c\u4ee4\u4eba\u9f13\u821e\u3002\u6b64\u5916\uff0c\u4e24\u9879\u5e73\u884c\u7684II\u671f\u7814\u7a76\u62a5\u544a\u4e86\u4e2d\u548cCD73\u7684\u5355\u514b\u9686\u6297\u4f53\uff08oleclumab\uff09\u8054\u5408PDL1\u963b\u6ede\u5242durvalumab\u5728\u53ef\u624b\u672f\u7684NSCLC\u60a3\u8005\u4e2d\u4f5c\u4e3a\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u6216\u5728\u4e0d\u53ef\u624b\u672f\u7684NSCLC\u60a3\u8005\u4e2d\u4f5c\u4e3a\u6cbb\u7597\u7684\u4e00\u90e8\u5206\uff0c\u663e\u793a\u51fa\u4e86\u5f88\u6709\u524d\u666f\u7684\u6d3b\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u76f8\u53cd\uff0c\u5c3d\u7ba1\u5df2\u6709\u5927\u91cf\u7814\u7a76\u8bc4\u4f30\u5e76\u5c06\u7ee7\u7eed\u8bc4\u4f30CD39\u963b\u6ede\u5242\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u5e94\u7528\uff0c\u4f46\u5176\u4e34\u5e8a\u9002\u7528\u6027\u4ecd\u4e0d\u786e\u5b9a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">6.5 \u8102\u80aa\u9178<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u636e\u62a5\u9053\uff0cCPT1\u963b\u65ad\u5242Etomoxir\u4e0eCD47\u9776\u5411\u6297\u4f53\u548c\u653e\u7597\u8054\u5408\u4f7f\u7528\uff0c\u53ef\u4ee5\u534f\u540c\u5bf9\u6297\u5728\u9885\u5185\u5efa\u7acb\u7684\u653e\u5c04\u6297\u6027\u5c0f\u9f20\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\uff0c\u5e76\u4e0e\u5de8\u566c\u7ec6\u80de\u4f9d\u8d56\u7684\u764c\u7ec6\u80de\u541e\u566c\u529f\u80fd\u6062\u590d\u6709\u5173\u3002\u7136\u800c\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8fd9\u4e9b\u53d1\u73b0\u662f\u5426\u53ef\u4ee5\u8f6c\u5316\u4e3a\u4eba\u7c7bGBM\u3002\u5728\u5375\u5de2\u764c\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0c\u836f\u7269\u6d45\u84dd\u83cc\u7d20\u5bf9FASN\u8fdb\u884c\u6291\u5236\uff0c\u88ab\u8bc1\u660e\u53ef\u4ee5\u901a\u8fc7\u6548\u5e94T\u7ec6\u80de\u6062\u590dDC\u7684\u6d3b\u5316\u548c\u80bf\u7624\u6d78\u6da6\uff0c\u8fd9\u4e0e\u90e8\u5206\u80bf\u7624\u63a7\u5236\u76f8\u5173\u3002\u4e0e\u8fd9\u4e9b\u53d1\u73b0\u4e00\u81f4\uff0cFASN\u6291\u5236\u5242Denifanstat\uff08\u4e5f\u79f0\u4e3aTCB-2640\uff09\u5728\u665a\u671f\u80bf\u7624\u548c\u9ad8\u7ea7\u522b\u661f\u5f62\u7ec6\u80de\u7624\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u8fd9\u4fc3\u4f7f\u6211\u4eec\u542f\u52a8\u4e86\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff08ClinicalTrials.gov: NCT02980029\u3001NCT03179904\u3001NCT03808558\u3001NCT05743621\uff09\u3002\u5728\u80f0\u817a\u764c\u548c\u9ed1\u8272\u7d20\u7624\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\uff0cCD36\u963b\u65ad\u5242\u4e0e\u514d\u75ab\u539f\u6027\u514d\u75ab\u7597\u6cd5\u8054\u5408\u4f7f\u7528\u4e5f\u663e\u793a\u51fa\u524d\u666f\uff0c\u4f46\u5c06CD36\u963b\u65ad\u5242\u5f00\u53d1\u4e3a\u4e34\u5e8a\u53ef\u7528\u836f\u7269\u7684\u8fc7\u7a0b\u4ecd\u5904\u4e8e\u521d\u7ea7\u9636\u6bb5\u3002\u76ee\u524d\u53ea\u6709\u4e00\u79cd\u836f\u7269\uff08VT1021\uff09\u2014\u2014\u9776\u5411CD36\u914d\u4f53\u8840\u5c0f\u677f\u53cd\u5e94\u86cb\u767d1\uff08THBS1\uff09\u2014\u2014\u6b63\u5728\u8bc4\u4f30\u5176\u7528\u4e8eGBM\u7684\u6cbb\u7597\uff08ClinicalTrials.gov: NCT03970447\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"color: rgb(203, 47, 21);\">\n<p style=\"text-wrap: wrap;\">6.6 \u4e8c\u5341\u70f7\u7c7b<\/p>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: 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style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u7b2c\u4e09\uff0c\u76ee\u524d\u5927\u591a\u6570\u4e34\u5e8a\u524d\u80bf\u7624\u6a21\u578b\u672a\u80fd\u518d\u73b0\u4eba\u7c7b\u80bf\u7624\u7684\u4ee3\u8c22\u548c\u514d\u75ab\u5f02\u8d28\u6027\u3002\u643a\u5e26\u975e\u5206\u79bb\u7684\u60a3\u8005\u6765\u6e90\u7269\u8d28\u5e76\u6709\u60a3\u8005\u6765\u6e90\u9020\u8840\u524d\u4f53\u7ec6\u80de\u5b9a\u690d\u7684\u4eba\u6e90\u5316\u5c0f\u9f20\u53ef\u80fd\u90e8\u5206\u7ed5\u8fc7\u8fd9\u4e00\u95ee\u9898\uff0c\u4f46\u8fd9\u4e9b\u5c0f\u9f20\u4e5f\u6709\u81ea\u5df1\u7684\u5c40\u9650\u6027\u3002\u6700\u540e\uff0c\u4e00\u4e9b\u4e0e\u5bbf\u4e3b\u76f8\u5173\u7684\u56e0\u7d20\u5df2\u88ab\u8bc1\u660e\u5f71\u54cd\u764c\u7ec6\u80de\u7684\u4ee3\u8c22\u548c\/\u6216\u514d\u75ab\u529f\u80fd\uff0c\u4e0d\u4ec5\u5305\u62ec\u660e\u663e\u7684\u5168\u8eab\u6027\u75be\u75c5\uff0c\u5982\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\uff0c\u8fd8\u5305\u62ec\u4e00\u4e9b\u4e0d\u592a\u5bb9\u6613\u8bc6\u522b\u7684\u53d8\u91cf\uff0c\u5982\u80bf\u7624\u5185\u548c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7684\u4e30\u5ea6\u548c\u7ec4\u6210\u3002\u6211\u4eec\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u8fd9\u4e9b\u56e0\u7d20\u3001\u764c\u7ec6\u80de\u4ee3\u8c22\u548c\u80bf\u7624\u9776\u5411\u514d\u75ab\u4e4b\u95f4\u9519\u7efc\u590d\u6742\u7684\u673a\u5236\u8054\u7cfb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(241, 248, 240);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\">\u5c3d\u7ba1\u5b58\u5728\u8fd9\u4e9b\u548c\u5176\u4ed6\u6311\u6218\uff0c\u764c\u7ec6\u80de\u4ee3\u8c22\u4ecd\u662f\u6062\u590d\u514d\u75ab\u76d1\u89c6\u7684\u4e00\u4e2a\u6709\u5e0c\u671b\u7684\u9776\u70b9\uff0c\u53ef\u4ee5\u5c06\u201c\u51b7\u201d\u80bf\u7624\u8f6c\u5316\u4e3a\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u201c\u70ed\u201d\u75c5\u53d8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"display: inline-block;width: 100%;border-width: 2px;border-style: dashed;border-color: rgb(192, 200, 209);padding: 10px;background-color: rgb(250, 250, 239);border-radius: 0.7em;\">\n<section style=\"color: rgb(0, 0, 0);\">\n<p style=\"text-wrap: wrap;\"><span style=\"color: rgb(203, 47, 21);\">\u672f\u8bed\u8868<\/span><\/p>\n<p style=\"text-wrap: wrap;\">\u5408\u6210\u4ee3\u8c22:\u4e00\u7ec4\u4ee3\u8c22\u9014\u5f84\uff0c\u7531\u8f83\u5c0f\u7684\u5355\u4f4d\u6784\u5efa\u5927\u5206\u5b50\uff0c\u4ee5\u652f\u6301\u7ec6\u80de\u751f\u957f\u548c\u589e\u6b96\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u81ea\u566c:\u4e00\u79cd\u6eb6\u9176\u4f53\u4f9d\u8d56\u7684\u5206\u89e3\u4ee3\u8c22\u9014\u5f84\uff0c\u786e\u4fdd\u591a\u4f59\u7684\u3001\u529f\u80fd\u969c\u788d\u7684\u6216\u6f5c\u5728\u7684\u7ec6\u80de\u6bd2\u6027\u7ec6\u80de\u8d28\u7269\u8d28\u7684\u964d\u89e3\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de(CAFs):\u4e00\u7fa4\u5f02\u8d28\u6027\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u5b9a\u4e49\u80bf\u7624\u95f4\u8d28\uff0c\u5e76\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u7684\u6076\u6027\u548c\u514d\u75ab\u6210\u5206\u6c9f\u901a\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5206\u89e3\u4ee3\u8c22:\u4e00\u7ec4\u4ee3\u8c22\u9014\u5f84\uff0c\u5c06\u5927\u5206\u5b50\u5206\u89e3\u6210\u66f4\u5c0f\u7684\u5355\u4f4d\uff0c\u4ee5\u4fbf\u518d\u5faa\u73af\u6216\u4ea7\u751fATP\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5df4\u8c46\u9170\u5316:\u5df4\u8c46\u9170\u8f85\u9176a\u5bf9\u8d56\u6c28\u9178\u6b8b\u57fa\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u4ece\u5934\u8102\u8d28\u751f\u7269\u5408\u6210:\u5c06\u4e59\u9170\u8f85\u9176A\u8f6c\u5316\u4e3a\u7528\u4e8e\u7ec6\u80de\u5408\u6210\u4ee3\u8c22\u7684\u957f\u94fe\u8102\u8d28\u7684\u4ee3\u8c22\u7ea7\u8054\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242(ICIs):\u9776\u5411\u5171\u6291\u5236\u6027T\u7ec6\u80de\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u652f\u6301\u6062\u590d\u6297\u764c\u514d\u75ab\u76d1\u89c6<\/p>\n<p style=\"text-wrap: wrap;\">\u4e73\u9178\u5316:\u4e73\u9178\u5bf9\u8d56\u6c28\u9178\u6b8b\u57fa\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de(MDSCs):\u4f4e\u5206\u5316\u7684\u9ad3\u7cfb\u7ec6\u80de\uff0c\u5177\u6709\u663e\u8457\u7684\u514d\u75ab\u6291\u5236\u548c\u4fc3\u8fdb\u80bf\u7624\u7684\u7279\u6027\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u6c27\u5316\u78f7\u9178\u5316(OXPHOS):\u7531\u4e09\u7fa7\u9178\u5faa\u73af(TCA\u5faa\u73af)\u63d0\u4f9b\u7684NADH\u548c\u7425\u73c0\u9178\u63d0\u4f9b\u7684\u7ebf\u7c92\u4f53\u9014\u5f84\uff0c\u901a\u8fc7\u4e00\u7cfb\u5217\u6c27\u5316\u53cd\u5e94\u4ea7\u751fATP\uff0c\u6700\u7ec8\u751f\u6210H2O\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u78f7\u9178\u620a\u7cd6\u9014\u5f84:\u4e00\u79cd\u4ee3\u8c22\u5206\u6d41\uff0c\u5c06\u7cd6\u9175\u89e3\u4e2d\u95f4\u4f53\u8f6c\u5411\u6838\u82f7\u9178\u3001\u67d0\u4e9b\u6c28\u57fa\u9178\u548c\u6297\u6c27\u5316\u5242\u7684\u5408\u6210\u3002<\/p>\n<p style=\"text-wrap: wrap;\">T\u7ec6\u80de\u8017\u7aed:\u5728\u8bb8\u591a\u6162\u6027\u611f\u67d3\u548c\u764c\u75c7\u4e2d\u51fa\u73b0\u7684\u4e00\u79cdT\u7ec6\u80de\u529f\u80fd\u969c\u788d\u72b6\u6001\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u4e09\u7fa7\u9178\u5faa\u73af(TCA\u5faa\u73af):\u4e00\u79cd\u7ebf\u7c92\u4f53\u56de\u8def\uff0c\u786e\u4fdd\u53c2\u4e0e\u6570\u79cd\u5206\u89e3\u4ee3\u8c22\u548c\u5408\u6210\u4ee3\u8c22\u53cd\u5e94(\u5305\u62ec\u4e59\u9170\u8f85\u9176A\u3001\u4e19\u916e\u9178\u76d0\u3001\u8349\u4e59\u9178\u76d0\u3001\u7425\u73c0\u9178\u76d0\u548c\u03b1-\u916e\u620a\u4e8c\u9178)\u7684\u5173\u952e\u4ee3\u8c22\u7269\u8fbe\u5230\u8db3\u591f\u6c34\u5e73\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(TAMs):\u80bf\u7624\u5185\u5de8\u566c\u7ec6\u80de\u7684\u5f02\u8d28\u6027\u548c\u53ef\u5851\u6027\u7fa4\u4f53\uff0c\u5176\u6d3b\u6027\u8303\u56f4\u4ece\u663e\u8457\u7684\u6297\u80bf\u7624(m1\u6837TAMs)\u5230\u663e\u8457\u7684\u4fc3\u80bf\u7624(m2\u6837TAMs)\u3002\u5c06\u8fd9\u4e9b\u4f53\u5916\u5b9a\u4e49\u7684M1\u548cM2\u8868\u578b\u5916\u63a8\u5230\u4f53\u5185\u65f6\u5e94\u8c28\u614e\u3002<\/p>\n<p style=\"text-wrap: wrap;\">\u5c3f\u7d20\u5faa\u73af:\u5c06\u591a\u4f59\u7684\u6c28\u8f6c\u5316\u4e3a\u5c3f\u7d20\u6392\u6cc4\u7684\u4ee3\u8c22\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.5em;\" class=\"js_darkmode__119\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.5em;\"><span data-style=\"outline: 0px; color: rgb(0, 0, 0); font-size: 12px;\" class=\"js_darkmode__120\" style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 12px;\">\u2014 THE &nbsp;END \u2014<\/span><\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.5em;\" class=\"js_darkmode__121\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u6765\u6e90&nbsp;| Nat Rev Immunol.<\/span><\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.5em;\" class=\"js_darkmode__122\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\">\u7b5b\u9009\u6574\u7406<span style=\"outline: 0px;letter-spacing: 0.544px;\">&nbsp;| \u738b\u5764<\/span><\/span><\/span><\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.5em;\" class=\"js_darkmode__123\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\">\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u53ef\u8f6c\u5230\u6587\u7ae0\u9875\u9762<br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/span><\/span><\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(34, 34, 34); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.5em;\" class=\"js_darkmode__124\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(34, 34, 34);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.5em;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><span style=\"outline: 0px;letter-spacing: 0.544px;text-decoration-style: solid;text-decoration-color: rgb(136, 136, 136);\"><span data-style=\"outline: 0px; color: rgb(255, 0, 0); letter-spacing: 0.544px;\" class=\"js_darkmode__125\" style=\"outline: 0px;color: rgb(255, 0, 0);letter-spacing: 0.544px;\">\u516c\u4f17\u53f7\u53d1\u90012024042224\u53ef\u83b7\u53d6\u6587\u732e\u5168\u6587<\/span><\/span><\/span><\/section>\n<p data-style=\"margin-bottom: 0px; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255);\" class=\"js_darkmode__126\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;color: rgb(163, 163, 163) !important;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; background-color: rgb(255, 255, 255); color: rgb(53, 53, 53); font-size: 14px; font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; text-align: center; line-height: 1.6em;\" class=\"js_darkmode__127\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(53, 53, 53);letter-spacing: 0.544px;text-wrap: wrap;font-size: 14px;font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;text-align: center;line-height: 1.6em;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(163, 163, 163) !important;\" class=\"js_darkmode__128\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;color: rgb(163, 163, 163) !important;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0px; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255);\" class=\"js_darkmode__129\" style=\"margin-bottom: 0px;outline: 0px;background-color: rgb(255, 255, 255);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;color: rgb(163, 163, 163) !important;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<section data-style=\"margin-bottom: 8px; outline: 0px; font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(163, 163, 163) !important;\" class=\"js_darkmode__130\" style=\"margin-bottom: 8px;outline: 0px;background-color: rgb(255, 255, 255);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;color: rgb(163, 163, 163) !important;\"><strong style=\"outline: 0px;text-indent: 0em;font-family: mp-quote, -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;letter-spacing: 0.54px;text-align: center;visibility: visible;\"><strong data-style=\"outline: 0px; color: rgb(64, 118, 0); font-family: Arial, sans-serif; letter-spacing: 2px; visibility: visible;\" class=\"js_darkmode__131\" style=\"outline: 0px;color: rgb(64, 118, 0);font-family: Arial, sans-serif;letter-spacing: 2px;visibility: visible;\">\u2589&nbsp; \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n<section data-style=\"margin-bottom: 0px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); font-family: -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif; visibility: visible; color: rgb(163, 163, 163) !important;\" 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font-family: Arial, sans-serif; letter-spacing: 2px; visibility: visible;\" class=\"js_darkmode__133\" data-filtered=\"filtered\" style=\"outline: 0px;color: rgb(64, 118, 0);font-family: Arial, sans-serif;letter-spacing: 2px;visibility: visible;\"><\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;letter-spacing: 0.544px;visibility: visible;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;visibility: visible;\">\n<section style=\"margin-bottom: 0em;outline: 0px;visibility: visible;\">\n<section style=\"outline: 0px;visibility: visible;line-height: 2em;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;outline: 0px;text-align: center;justify-content: center;display: flex;flex-flow: row;visibility: visible;\">\n<section data-style=\"padding: 29px; outline: 0px; display: inline-block; width: 677px; vertical-align: top; background-color: rgba(97, 155, 139, 0.09); align-self: flex-start; flex: 0 0 auto; visibility: visible;\" style=\"padding: 29px;outline: 0px;display: inline-block;width: 677px;vertical-align: top;background-color: rgba(97, 155, 139, 0.09);align-self: flex-start;flex: 0 0 auto;visibility: visible;color: rgb(205, 205, 205) !important;\">\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;text-align: justify;visibility: visible;\">\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2826543872209125379&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;color: var(--weui-LINK);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;cursor: pointer;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?__biz=MzAwMDUzNTIxNA==&amp;action=getalbum&amp;album_id=1647467076418060289#wechat_redirect\" textvalue=\"\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener\">\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2018077716062715908&amp;count=3#wechat_redirect\" textvalue=\"\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=2822922341205737475&amp;count=3#wechat_redirect\" textvalue=\"ACIR\u6587\u732e\u901f\u9012\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564295698236358662&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u4f5c\u56fe\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564293167342993409&amp;count=3#wechat_redirect\" textvalue=\"SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1894714083283615746&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDUzNTIxNA==&amp;mid=2456254175&amp;idx=1&amp;sn=d302a786f8fea3868ee719195418af61&amp;scene=21#wechat_redirect\" textvalue=\"R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564291300860936193&amp;count=3#wechat_redirect\" textvalue=\"\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;font-size: 17px;\" rel=\"noopener\"><span style=\"outline: 0px;\">\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;color: var(--weui-LINK);font-family: system-ui, -apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;cursor: pointer;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564278007870046209&amp;count=3#wechat_redirect\" textvalue=\"RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;letter-spacing: 0.544px;\" rel=\"noopener\">RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n<p style=\"outline: 0px;visibility: visible;\"><span style=\"outline: 0px;letter-spacing: 0.544px;font-size: 17px;\"><a target=\"_blank\" href=\"https:\/\/mp.weixin.qq.com\/mp\/appmsgalbum?action=getalbum&amp;__biz=MzAwMDUzNTIxNA==&amp;scene=1&amp;album_id=1564286064490496000&amp;count=3#wechat_redirect\" textvalue=\"\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b\" linktype=\"text\" imgurl=\"\" imgdata=\"null\" tab=\"innerlink\" data-linktype=\"2\" style=\"outline: 0px;color: var(--weui-LINK);cursor: pointer;\" rel=\"noopener\">\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section powered-by=\"xiumi.us\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;\">\n<section powered-by=\"xiumi.us\" mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;letter-spacing: 0.544px;\">\n<section mpa-from-tpl=\"t\" style=\"outline: 0px;\">\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__134\" style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__135\" style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\"><img decoding=\"async\" class=\"rich_pages wxw-img js_darkmode__136\" data-cropselx1=\"0\" data-cropselx2=\"162\" data-cropsely1=\"0\" data-cropsely2=\"162\" data-fileid=\"308764751\" data-imgfileid=\"308773825\" data-ratio=\"1\" data-s=\"300,640\" data-type=\"jpeg\" data-w=\"258\" width=\"162px\"  style=\"outline: 0px;color: rgb(0, 0, 0);font-size: 14px;letter-spacing: 0.54px;display: initial;visibility: visible !important;width: 161.969px !important;\" src=\"http:\/\/oncolab.cn\/wp-content\/uploads\/2025\/01\/wxsync-2025-01-a3f870d15872aa84f61f506373575ea1.webp\"  \/><\/span><\/p>\n<p 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0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n<p style=\"outline: 0px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__141\" style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-bottom: 0em; outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" 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0.54px;text-align: center;\"><span style=\"outline: 0px;color: rgb(136, 136, 136);font-size: 12px;\">\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__144\" style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; font-size: 14px; letter-spacing: 0.54px; text-align: center;\" class=\"js_darkmode__145\" style=\"outline: 0px;color: rgb(0, 0, 0);font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 14px;letter-spacing: 0.54px;text-align: center;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"outline: 0px; color: rgb(0, 0, 0); font-family: 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-apple-system, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;color: rgb(163, 163, 163) !important;\"><br data-filtered=\"filtered\" style=\"outline: 0px;\"  \/><\/p>\n<p data-style=\"margin-right: 8px; margin-bottom: 0px; margin-left: 8px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; widows: 1; text-align: right; line-height: 1.6em;\" class=\"js_darkmode__148\" style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span data-style=\"outline: 0px; background-color: rgb(249, 237, 166); font-size: 15px; color: rgb(67, 67, 67) !important;\" class=\"js_darkmode__149\" style=\"outline: 0px;background-color: rgb(249, 237, 166);font-size: 15px;color: rgb(67, 67, 67) !important;\">\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b&nbsp;<\/span><\/p>\n<p data-style=\"margin-right: 8px; margin-bottom: 0px; margin-left: 8px; outline: 0px; letter-spacing: 0.544px; text-wrap: wrap; font-size: 16px; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-family: \u5fae\u8f6f\u96c5\u9ed1; widows: 1; text-align: right; line-height: 1.6em;\" class=\"js_darkmode__150\" style=\"margin-right: 8px;margin-bottom: 0px;margin-left: 8px;outline: 0px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);letter-spacing: 0.544px;text-wrap: wrap;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;widows: 1;text-align: right;line-height: 1.6em;\"><span data-style=\"outline: 0px; background-color: rgb(249, 237, 166); font-size: 15px; color: rgb(67, 67, 67) !important;\" class=\"js_darkmode__151\" style=\"outline: 0px;background-color: rgb(249, 237, 166);font-size: 15px;color: rgb(67, 67, 67) !important;\">\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n<p style=\"display: none;\"><mp-style-type data-value=\"3\"><\/mp-style-type><\/p>\n<blockquote>\n<p>\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7:                 OncoLab              <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>1.\u6458\u8981 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