{"id":3562,"date":"2023-11-27T17:37:17","date_gmt":"2023-11-27T09:37:17","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/11\/27\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac25%e7%ab%a0%ef%bc%9a%e5%85%88%e5%a4%a9%e5%85%8d%e7%96%ab%e5%8f%97%e4%bd%93%e5%9c%a8%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82\/"},"modified":"2023-11-27T17:37:17","modified_gmt":"2023-11-27T09:37:17","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac25%e7%ab%a0%ef%bc%9a%e5%85%88%e5%a4%a9%e5%85%8d%e7%96%ab%e5%8f%97%e4%bd%93%e5%9c%a8%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/11\/27\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac25%e7%ab%a0%ef%bc%9a%e5%85%88%e5%a4%a9%e5%85%8d%e7%96%ab%e5%8f%97%e4%bd%93%e5%9c%a8%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c25\u7ae0\uff1a\u5148\u5929\u514d\u75ab\u53d7\u4f53\u5728\u80bf\u7624\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09"},"content":{"rendered":"
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<\/p>\n<\/section>\n<\/section>\n

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25.1 \u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u764c\u75c7\u514d\u75ab\u76d1\u89c6\uff0c\u5373\u514d\u75ab\u7cfb\u7edf\u641c\u7d22\u5e76\u8bc6\u522b\u4f53\u5185\u764c\u75c7\u548c\u764c\u7ec6\u80de\u7684\u8fc7\u7a0b\uff0c\u5176\u5386\u53f2\u53ef\u4ee5\u8ffd\u6eaf\u523020\u4e16\u7eaa\u521d\uff0c\u5f53\u65f6\u4fdd\u7f57\u00b7\u57c3\u5c14\u5229\u5e0c\u5c31\u9884\u6d4b\u514d\u75ab\u7cfb\u7edf\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n

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25.1.1 TLRs \u5728\u8c03\u63a7\u80bf\u7624\u53d1\u751f\u4e2d\u7684\u4f5c\u7528<\/p>\n<\/section>\n

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\u5230\u76ee\u524d\u4e3a\u6b62\uff0cTLR \u5bb6\u65cf\u53d7\u4f53\u662f\u6700\u5bb9\u6613\u7406\u89e3\u7684\u5148\u5929\u4fe1\u53f7 PRRs \u7c7b\u7fa4\uff0c\u5b83\u4eec\u662f\u75c5\u539f\u4f53\u611f\u67d3\u7684\u54e8\u5175\u3002TLRs\u53ef\u4ee5\u8bc6\u522b\u5fae\u751f\u7269PAMPs\uff0c\u5e76\u901a\u8fc7\u52df\u96c6\u540c\u6e90\u63a5\u5934\u86cb\u767d\u6765\u53d1\u51fa\u4fe1\u53f7\u3002<\/p>\n

\u4e00\u822c\u6765\u8bf4\uff0cTLRs \u901a\u5e38\u5229\u7528\u88ab\u79f0\u4e3a\u9ad3\u7cfb\u5206\u5316\u4e3b\u8981\u53cd\u5e94\u57fa\u56e0 88\uff08MyD88\uff09\u7684\u9002\u914d\u4f53\u4f5c\u4e3a\u5176\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\uff1b\u7136\u800c\uff0cTLR3 \u5219\u5229\u7528\u542b TIR \u7ed3\u6784\u57df\u7684\u9002\u914d\u4f53\u8bf1\u5bfc IFN-\u03b2\uff08TRIF\uff0c\u53c8\u79f0 TICAM\uff09\u4fe1\u53f7\u4f20\u5bfc\u9014\u5f84\uff0c\u5c3d\u7ba1\u6709\u8bc1\u636e\u8868\u660e\u5b83\u4e5f\u5229\u7528 MyD88 \u9014\u5f84\u3002TLR4\u540c\u65f6\u9700\u8981MyD88\u548cTRIF\u901a\u8def\u624d\u80fd\u5b8c\u5168\u6fc0\u6d3b\u4e0b\u6e38\u7684\u4fe1\u53f7\u7ea7\u8054\u3002<\/p>\n

\u5728\u4e0eTLRs\u7ed3\u5408\u540e\uff0c\u63a5\u5934\u86cb\u767d\u4e0e\u5176\u4ed6\u4e0b\u6e38\u86cb\u767d\u8d28\u7ed3\u5408\uff0c\u8fd9\u4e9b\u4e0b\u6e38\u86cb\u767d\u8d28\u4ecb\u5bfc\u8f6c\u5f55\u56e0\u5b50\u548c\u86cb\u767d\u6fc0\u9176\u7684\u6fc0\u6d3b\uff0c\u5982NF-kappaB(NF-\u03baB)\u3001\u5e72\u6270\u7d20\u8c03\u8282\u56e0\u5b50(IRFs)\u548c\u4e1d\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176(MAPK)\uff0c\u4ee5\u8c03\u8282\u9776\u57fa\u56e0\u7684\u8f6c\u5f55\uff0c\u5982I\u578bIFN\u548c\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u8f6c\u5f55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLRs\u5728\u6297\u539f\u63d0\u5448\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u4e00\u4e9bTLRs\u7684\u6fc0\u6d3b\u8bf1\u5bfc\u6297\u80bf\u7624\u4ecb\u8d28\uff0c\u5982I\u578bIFN\uff0c\u8fd9\u4fc3\u4f7f\u4eba\u4eec\u52aa\u529b\u5229\u7528 TLR \u6fc0\u52a8\u5242\u6765\u6cbb\u7597\u80bf\u7624\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0cTLRs\u662f\u6fc0\u6d3b\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u91cd\u8981\u6cbb\u7597\u9776\u70b9\uff0c\u6700\u521d\u56e0Coley\u6bd2\u7d20\u548c\u5361\u4ecb\u82d7(BCG)\u76f8\u5173\u7684\u6297\u764c\u53cd\u5e94\u800c\u88ab\u91cd\u89c6\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0cTLR\u4fe1\u53f7\u4e5f\u8bf1\u5bfc\u708e\u75c7\u53cd\u5e94\uff0c\u56e0\u6b64\u4e5f\u53ef\u80fd\u6709\u5229\u4e8e\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n

\u4e00\u4e2a\u65b0\u5174\u7684\u6982\u5ff5\u662f\uff0c\u9664\u4e86PAMP\uff0cTLRs\u8fd8\u8bc6\u522b\u4e00\u7cfb\u5217\u88ab\u79f0\u4e3a\u635f\u4f24\u76f8\u5173\u5206\u5b50\uff08DAMPs\uff09\u7684\u81ea\u6211\u884d\u751f\u5206\u5b50\uff0c\u5b83\u4eec\u5728\u7ec6\u80de\u5e94\u6fc0\u65f6\u91ca\u653e\uff0c\u53ef\u6539\u53d8 TME\u3002<\/p>\n

\u56e0\u6b64\uff0c\u5982\u4e0b\u6240\u8ff0\uff0cTLRs\u660e\u663e\u5730\u540c\u65f6\u8868\u73b0\u51fa\u4e86\u4fc3\u80bf\u7624\u548c\u6297\u80bf\u7624\u529f\u80fd\u3002\u8fd9\u53ef\u80fd\u5f52\u56e0\u4e8e\u4e0d\u540c\u7684\u81f4\u7624\u65b9\u6848\u6216\u5c0f\u9f20\u7c7b\u578b\uff0c\u5b83\u4eec\u4f1a\u5f71\u54cd\u80bf\u7624\u7684\u53d1\u80b2\u8fc7\u7a0b\u548c\u5171\u751f\u83cc\u7fa4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLR1\/2\/6<\/strong>\u8fd9\u4e9bTLR\u8868\u8fbe\u5728\u7ec6\u80de\u8868\u9762\u3002<\/p>\n

TLR2\u4e0eTLR1\u6216TLR6\u5f62\u6210\u5f02\u4e8c\u805a\u4f53\uff0c\u8bc6\u522b\u591a\u79cdPAMP\uff0c\u5305\u62ec\u8102\u80bd\u3001\u80bd\u805a\u7cd6\u3001\u8102\u78f7\u58c1\u9178\u3001\u8102\u963f\u62c9\u4f2f\u7518\u9732\u805a\u7cd6\u3001\u9175\u6bcd\u591a\u7cd6\u3001\u514b\u6c0f\u9525\u866b\u7684\u7cd6\u57fa\u78f7\u8102\u9170\u808c\u9187\u951a\u5b9a\u7684\u7c98\u86cb\u767d\u6837\u7cd6\u86cb\u767d\u4ee5\u53ca\u7ec6\u83cc\u6216\u9175\u6bcd\u7684\u8840\u51dd\u7d20\u86cb\u767d\u3002<\/p>\n

TLR2\u8fd8\u88ab\u8bc1\u660e\u80fd\u591f\u8bc6\u522b\u5185\u6e90\u6027\u914d\u4f53\uff0c\u5982\u53cc\u805a\u7cd6\u3001\u900f\u660e\u8d28\u9178\u3001\u4e07\u897f\u5eb7\u548c\u8868\u9762\u6d3b\u6027\u86cb\u767dA\u3002\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u4e5f\u5df2\u7ecf\u8fdb\u884c\u4e86TLR2\u5728\u80bf\u7624\u53d1\u751f\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\u7684\u7814\u7a76\uff0c\u6709\u8bc1\u636e\u8868\u660eTLR2\u4fe1\u53f7\u53ef\u80fd\u53d1\u6325\u6297\u80bf\u7624\u6216\u4fc3\u80bf\u7624\u529f\u80fd\uff0c\u5176\u53d1\u6325\u7684\u529f\u80fd\u53d6\u51b3\u4e8e\u6240\u7814\u7a76\u7684\u6a21\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u5355\u6b21\u6ce8\u5c04 N-\u4e9a\u785d\u57fa\u4e8c\u4e59\u80fa\uff08DEN\uff09\u540e\u91cd\u590d\u6ce8\u5c04\u56db\u6c2f\u5316\u78b3\uff08CCl 4\uff09\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u6a21\u578b\uff08\u4ee5\u4e0b\u79f0 DEN\/CCl 4 \u6a21\u578b\uff09\u4e2d\uff0cTLR2 \u7f3a\u9677\u5c0f\u9f20\u8868\u73b0\u51fa\u80bf\u7624\u751f\u957f\u52a0\u5267\u3002\u7814\u7a76\u8868\u660e\uff0c\u5305\u62ec\u5e72\u6270\u7d20-\u03b3\u8868\u8fbe\u53d7\u635f\u3001\u7ec6\u80de\u8870\u8001\u548c\u4e27\u5931\u81ea\u566c\u5728\u5185\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u51cf\u5f31\u662f\u80bf\u7624\u751f\u957f\u6269\u5927\u7684\u539f\u56e0\u3002<\/p>\n

\u540c\u6837\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5728DEN\/CCL4\u6a21\u578b\u4e2d\uff0cTLR2\u7f3a\u9677\u5c0f\u9f20\u4f1a\u7f79\u60a3\u66f4\u591a\u66f4\u5927\u7684\u80a0\u9053\u80bf\u7624\u3002\u80bf\u7624\u53d1\u5c55\u7684\u7279\u5f81\u662f\u80a0\u9053TME\u4e2dIL-6\u3001IL-17A\u7684\u589e\u52a0\u4ee5\u53ca\u4fe1\u53f7\u8f6c\u5bfc\u548c\u8f6c\u5f55\u6fc0\u6d3b\u52423(STAT3)\u78f7\u9178\u5316\u6c34\u5e73\u7684\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u53e6\u4e00\u65b9\u9762\uff0c\u5728STAT3\u8fc7\u5ea6\u6fc0\u6d3b\u7684\u5c0f\u9f20\u80c3\u764c\u6a21\u578b\u4e2d\uff0cTLR2\u7f3a\u4e4f\u5bfc\u81f4\u80bf\u7624\u8d1f\u8377\u51cf\u5c11\uff0c\u8868\u660eTLR2\u5177\u6709\u4fc3\u80bf\u7624\u4f5c\u7528\u3002\u8fd9\u79cd\u4f5c\u7528\u4e0e\u708e\u75c7\u65e0\u5173\uff0c\u5176\u7279\u5f81\u662f\u5bbf\u4e3b\u80c3\u4e0a\u76ae\u7ec6\u80de\u7684\u589e\u6b96\u53d7\u635f\u548c\u51cb\u4ea1\u589e\u52a0\u3002\u8fd9\u4e9b\u73b0\u8c61\u7684\u89e3\u91ca\u662f\u7531\u4e8eTLR2\u7f3a\u4e4f\u800c\u6291\u5236\u4e86\u8fd9\u4e9b\u7ec6\u80de\u4e2d\u7684\u78f7\u8102\u9170\u808c\u9187-3\u6fc0\u9176(PI3K)\u3001\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176(AKT)\u3001\u7ec6\u80de\u5916\u4fe1\u53f7\u8c03\u8282\u86cb\u767d\u6fc0\u9176(ERK1\/2)\u3001c-jun\u6c28\u57fa\u672b\u7aef\u6fc0\u9176(JNK)\u548cNF-\u03baB\u901a\u8def\u3002<\/p>\n

\u6b64\u5916\uff0cTLR2\u4fe1\u53f7\u4e5f\u53ef\u80fd\u5728\u7ef4\u6301\u6b63\u5e38\u5e72\u7ec6\u80de\u548c\u80c3\u764c\u7ec6\u80de\u7684\u201c\u5e72\u6027\u201d\u65b9\u9762\u53d1\u6325\u4f5c\u7528\u3002\u5728\u80ba\u764c\u6a21\u578b\u4e2d\uff0cTLR2\u7f3a\u9677\u5c0f\u9f20\u4e0e\u91ce\u751f\u578b(WT)\u5c0f\u9f20\u76f8\u6bd4\uff0cLLC\u7ec6\u80de\u7684\u8f6c\u79fb\u751f\u957f\u7684\u901f\u5ea6\u8f83\u6162\u3002WT\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u7684\u589e\u5f3a\u53ef\u80fd\u662f\u7531\u4e8eLLC\u884d\u751f\u7684Verscan\u6fc0\u6d3bTLR2\uff1aTLR6\u590d\u5408\u4f53\uff0c\u5bfc\u81f4\u9ad3\u6837\u7ec6\u80de\u5206\u6ccc\u53ef\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1(TNF-\u03b1)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

TLR3<\/strong> TLR3\u5b9a\u4f4d\u4e8e\u5185\u4f53\u4e2d\uff0c\u8bc6\u522b\u6765\u81ea\u75c5\u6bd2\u7684\u5185\u541e\u53cc\u94feRNA(DsRNA)\uff0c\u4ee5\u53ca\u4ece\u6b7b\u4ea1\u7ec6\u80de\u4e2d\u91ca\u653e\u7684\u884d\u751fmRNA\u3002<\/p>\n

\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0cTLR3\u5177\u6709\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u7684\u4f5c\u7528\u3002\u5728\u524d\u5217\u817a\u764c\u690d\u5165\u6027\u8f6c\u57fa\u56e0\u7684\u817a\u764c\u6a21\u578b\u4e2d\uff0cTLR3\u7f3a\u9677\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u901f\u5ea6\u6bd4\u5bf9\u7167\u7ec4\u5feb\u3002\u5728\u8fd9\u4e2a\u6a21\u578b\u4e2d\uff0cTLR3-I\u578b\u5e72\u6270\u7d20\u4fe1\u53f7\u901a\u8def\u589e\u5f3a\u4e86NK\u7ec6\u80de\u7684\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n

\u4e0e\u6b64\u4e00\u81f4\u7684\u662f\uff0c\u4e00\u4e9b\u7814\u7a76\u5df2\u7ecf\u68c0\u9a8c\u4e86\u5408\u6210\u7684TLR3\u914d\u4f53\u805a\u808c\u82f7\u80de\u9178(PolyI\uff1aC)\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u7597\u6548\u3002PolyI\uff1aC-TLR3\u8f74\u7684\u53ef\u80fd\u4f5c\u7528\u673a\u5236\u662f\uff1a(A)\u8bf1\u5bfcDC\u7ec6\u80de\u4e0a\u4f9d\u8d56IRF3\u7684NK\u6fc0\u6d3b\u5206\u5b50(INAM)\uff0c(B)\u80bf\u7624\u6d78\u6da6\u6027\u5de8\u566c\u7ec6\u80de\u5411M1\u8868\u578b\u504f\u79fb\uff0c\u4ee5\u53ca(C)\u6fc0\u6d3bDC\uff0c\u5305\u62ec\u4ea7\u751fI\u578bIFN\u4ee5\u589e\u5f3a\u6709\u6548\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u53e6\u4e00\u65b9\u9762\uff0cTLR3\u4e5f\u5728\u81ea\u53d1\u7684\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\uff0cTLR3\u7f3a\u9677\u5c0f\u9f20\u5728\u8be5\u6a21\u578b\u4e2d\u7684\u80ba\u8f6c\u79fb\u53d7\u5230\u6291\u5236\u3002<\/p>\n

\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c\u6765\u81ea\u80bf\u7624\u5916\u5207\u4f53\u7684RNA\u53ef\u6fc0\u6d3bTLR3\u5728\u80ba\u4e0a\u76ae\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\uff0c\u5bfc\u81f4\u4e2d\u6027\u7c92\u7ec6\u80de\u52df\u96c6\u548c\u8f6c\u79fb\u524d\u751f\u6001\u4f4d\u7684\u53d1\u5c55\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u5982\u4e0a\u6240\u8ff0\uff0c\u51e0\u5341\u5e74\u6765TLR3\u6fc0\u52a8\u5242Poly I\uff1aC\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6709\u524d\u9014\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4f50\u5242\u3002\u8fd9\u79cd\u7597\u6cd5\u867d\u7136\u6709\u6548\uff0c\u4f46\u5df2\u88ab\u8bc1\u660e\u4f1a\u5f15\u8d77\u5371\u53ca\u751f\u547d\u7684\u526f\u4f5c\u7528\uff0c\u5982\u5f15\u53d1\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u62a5\u544a\u4e86\u4e00\u79cd\u65b0\u578b\u7684\u5408\u6210RNA\uff0c\u65e8\u5728\u9009\u62e9\u6027\u5730\u6fc0\u6d3bTRIF\u9014\u5f84\uff0c\u4ece\u800c\u6709\u6548\u5730\u6fc0\u6d3b\u8377\u7624\u5c0f\u9f20\u7684NK\u7ec6\u80de\u548c\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff0c\u800c\u4e0d\u4f1a\u5f15\u53d1\u7531\u5176\u4ed6\u7c7b\u578b\u7684dsRNA\u8bf1\u5bfc\u7684\u4e25\u91cd\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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TLR4<\/strong> TLR4\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u5e76\u8bc6\u522b\u9769\u5170\u6c0f\u9634\u6027\u6746\u83cc\u7684\u4e3b\u8981\u7ec4\u5206\u4e4b\u4e00\u8102\u591a\u7cd6(LPS)\u3002<\/p>\n

\u636e\u62a5\u9053\uff0cTLR4\u8bc6\u522b\u591a\u79cd\u5185\u6e90\u6027\u914d\u4f53\uff0c\u5982\u9ad8\u8fc1\u79fb\u7387\u65cf\u86cb\u767d1(HMGB1)\u3001\u70ed\u4f11\u514b\u86cb\u767d(HSPs)\u3001\u53cc\u7cd6\u94fe\u86cb\u767d\u805a\u7cd6\u3001\u900f\u660e\u8d28\u9178\u7247\u6bb5\u548c\u6c27\u5316\u578b\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

\u5728\u5355\u5242\u91cf\u5076\u6c2e\u7532\u70f7(AOM)\u8054\u5408\u786b\u9178\u8461\u805a\u7cd6\u94a0(DSS)\u8054\u5408\u4f5c\u7528\u7684\u5c0f\u9f20\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d(\u4ee5\u4e0b\u79f0\u4e3aAOM\/DSS\u6a21\u578b)\uff0cTLR4\u7f3a\u9677\u5c0f\u9f20\u663e\u793a\u51fa\u80bf\u7624\u8d1f\u8377\u51cf\u5c11\uff0c\u8868\u660eTLR4\u5177\u6709\u4fc3\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cTLR4\u4fe1\u53f7(\u53ef\u80fd\u7531\u5171\u751f\u7ec6\u83cc\u6fc0\u6d3b)\u5728\u7ed3\u80a0\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8bf1\u5bfc(A)\u514d\u75ab\u6291\u5236\u73af\u6c27\u5316\u9176-2(COX-2)\uff0c(B)\u53cc\u8c03\u8282\u7d20\u6fc0\u6d3b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53(EGFR)\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u4ee5\u53ca(C)\u901a\u8fc7\u52df\u96c6\u8868\u8fbeCOX-2\u7684\u5de8\u566c\u7ec6\u80de\u5f62\u6210TME\u3002<\/p>\n

\u6839\u636e\u4e0a\u8ff0\u7ed3\u679c\uff0c\u5728\u80a0\u4e0a\u76ae\u7ec6\u80de\u4e2d\u643a\u5e26\u7684\u7ed2\u6bdb\u86cb\u767d\u542f\u52a8\u5b50\u4e0a\u5177\u6709\u6784\u6210\u6d3b\u6027\u7684TLR4\u86cb\u767d\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u5728\u540c\u4e00\u5c0f\u9f20\u6a21\u578b\u4e2d\u66f4\u5bb9\u6613\u53d1\u751f\u80bf\u7624\u3002\u7136\u800c\uff0c\u5728\u53e6\u4e00\u4e2a\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\uff0cTLR4\u663e\u793a\u51fa\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

\u5728\u81ea\u53d1\u6027\u80a0\u9053\u80bf\u7624\u53d1\u751f\u7684APCmin\/+\u5c0f\u9f20\u6a21\u578b(APCmin\u6a21\u578b)\u4e2d\uff0c\u80a0\u9053\u4e0a\u76ae\u7ec6\u80de\u4e2d\u5177\u6709\u56fa\u6709\u6d3b\u6027\u7684TLR4\u7684\u5c0f\u9f20\u663e\u793a\u51fa\u80bf\u7624\u8d1f\u8377\u51cf\u5c11\u3002\u4ece\u8fd9\u4e9b\u5c0f\u9f20\u7684\u80a0\u9053\u5206\u79bb\u7684\u80bf\u7624\u7ec6\u80de\u663e\u793aIFN-\u03b2\u7684\u8868\u8fbe\u589e\u52a0\u548c\u534a\u80f1\u5929\u51ac\u86cb\u767d\u9176-3\u7684\u6fc0\u6d3b\uff0c\u8fd9\u4e0e\u4f53\u5185\u7ec6\u80de\u51cb\u4ea1\u7684\u589e\u52a0\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u809d\u7ec6\u80de\u764c\u6a21\u578b\u4e2d\uff0c\u5373DEN\/CCL4\u6a21\u578b\u4e2d\uff0c\u4e0eWT\u5c0f\u9f20\u76f8\u6bd4\uff0cTLR4\u7f3a\u9677\u5c0f\u9f20\u7684\u80bf\u7624\u53d1\u5c55\u8f83\u6162\uff0c\u8fd9\u6697\u793a\u4e86TLR4\u4fe1\u53f7\u7684\u4fc3\u80bf\u7624\u529f\u80fd\u3002<\/p>\n

\u80a0\u9053\u7684\u5fae\u751f\u7269\u533a\u548c\u809d\u810f\u7ec6\u80de\u4e0a\u7684TLR4\u88ab\u8ba4\u4e3a\u95f4\u63a5\u7684\u4fc3\u8fdb\u4e86\u589e\u6b96\uff0c\u963b\u6b62\u4e86\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\u548c\u809d\u810f\u6709\u4e1d\u5206\u88c2\u539f\u8868\u76ae\u751f\u957f\u7d20\u7684\u8868\u8fbe\u3002<\/p>\n

\u540c\u6837\uff0c\u5728DEN\u8bf1\u5bfc\u7684\u809d\u764c\u6a21\u578b\u4e2d\uff0c\u89c2\u5bdf\u5230TLR4\u7f3a\u9677\u5c0f\u9f20\u7684\u809d\u764c\u53d1\u5c55\u51cf\u5c11\u3002\u7136\u800c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5728DEN\u8bf1\u5bfc\u7684\u809d\u764c\u6a21\u578b\u4e2d\uff0cTLR4\u7f3a\u9677\u5c0f\u9f20\u8868\u73b0\u51fa\u66f4\u9ad8\u7684\u80bf\u7624\u8d1f\u8377\u3002DNA\u7684\u53d7\u635f\u4fee\u590d\u548c\u968f\u540e\u7684\u6c27\u5316\u5e94\u6fc0\u53ef\u4ee5\u89e3\u91ca\u8fd9\u79cd\u764c\u53d8\u52a0\u5267\u7684\u539f\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u57287\uff0c12-\u4e8c\u7532\u57fa\u82ef\u5e76\u83f2(DMBA)\u548c\u5df4\u8c46\u6cb9\u8054\u5408\u8bf1\u5bfc\u7684\u76ae\u80a4\u764c\u6a21\u578b\u4e2d\uff0c\u7f3a\u4e4fTLR4\u7684\u5c0f\u9f20\u4e5f\u663e\u793a\u51fa\u6297\u764c\u80fd\u529b\uff0c\u8868\u660eTLR4\u4fe1\u53f7\u6709\u4fc3\u764c\u4f5c\u7528\u3002\u4ece\u673a\u7406\u4e0a\u8bb2\uff0c\u4ece\u6fd2\u6b7b\u7684\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u4e2d\u91ca\u653e\u51fa\u6765\u7684HMGB1\uff0c\u6fc0\u6d3bTLR4\u5e76\u589e\u5f3a\u708e\u75c7\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u5c55\u3002<\/p>\n

\u6b64\u5916\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u7684\u57fa\u56e0\u5de5\u7a0b\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5373HGF-CDK4(R24C)\u5c0f\u9f20\uff0c\u7531\u4e8e\u81f4\u764c CDK4(R24C) \u57fa\u56e0\u7a81\u53d8\uff0c\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08HGF\uff09\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u4fe1\u53f7\u4f20\u5bfc\u5931\u8c03\uff0c\u7ec6\u80de\u5468\u671f\u63a7\u5236\u53d7\u635f\uff0cTLR4 \u7684\u7f3a\u4e4f\u53ef\u6291\u5236\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684\u80ba\u8f6c\u79fb\u589e\u5f3a\u3002\u5728\u8fd9\u4e2a\u5b9e\u9a8c\u8bbe\u7f6e\u4e2d\uff0cTLR4\u88ab\u7d2b\u5916\u7ebf\u635f\u4f24\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u91ca\u653e\u7684\u7ec6\u80de\u5916HMGB1\u6fc0\u6d3b\uff0c\u5bfc\u81f4\u4e2d\u6027\u7c92\u7ec6\u80de\u52df\u96c6\uff0c\u8bf1\u5bfc\u8840\u7ba1\u751f\u6210\u548c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u5411\u5185\u76ae\u7ec6\u80de\u8fc1\u79fb\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5728DMBA\u76ae\u80a4\u764c\u6a21\u578b\u4e2d\uff0cTLR4\u7f3a\u9677\u5c0f\u9f20\u7684\u80bf\u7624\u8d1f\u62c5\u589e\u52a0\uff0c\u5e76\u4f34\u968f\u7740\u8840\u6e05IL-17\u6c34\u5e73\u7684\u5347\u9ad8\u548c\u5e72\u6270\u7d20-\u03b3\u6c34\u5e73\u7684\u964d\u4f4e\uff0c\u8fd9\u8868\u660eTh1\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u53cd\u5e94\u53d7\u635f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5173\u4e8eTLR4\u5728\u5176\u4ed6\u5668\u5b98\u4e2d\u7684\u4f5c\u7528\u7684\u62a5\u9053\u76f8\u5f53\u6709\u9650\u3002\u5728Kras G12D\u80f0\u817a\u764c\u6a21\u578b\u4e2d\uff0c\u9020\u8840\u7ec6\u80de\u5ba4\u4e2d\u7f3a\u4e4fTLR4\u7684\u5c0f\u9f20\u5728P48CRE\u4e2d\u80f0\u817a\u4e0a\u76ae\u5185\u7624\u75c5\u53d8\u51cf\u5c11\u3002<\/p>\n

\u76f8\u53cd\uff0cTLR4\u7f3a\u4e4f\u4f1a\u5728\u6ce8\u5c043-\u7532\u57fa\u80c6\u84bd\u548c\u4e01\u57fa\u7f9f\u57fa\u7532\u82ef(BHT)\u540e\u5bfc\u81f4\u80ba\u90e8\u80bf\u7624\u52a0\u91cd\u3002TLR4\u4e5f\u88ab\u8bc1\u660e\u5bf9DMBA\u8bf1\u5bfc\u7684\u4e73\u817a\u764c\u6a21\u578b\u548c4T1\u63a5\u79cd\u7684\u8f6c\u79fb\u6a21\u578b\u90fd\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n

TLR4\u4fe1\u53f7\u7684\u4fc3\u80bf\u7624\u6216\u6297\u80bf\u7624\u7ed3\u679c\u53ef\u80fd\u53d6\u51b3\u4e8eMyD88\u548cTRIF\u4fe1\u53f7\u901a\u8def\u7684\u6fc0\u6d3b\u72b6\u6001\uff0c\u8fd9\u4e24\u4e2a\u4fe1\u53f7\u901a\u8def\u5206\u522b\u5177\u6709\u4fc3\u80bf\u7624\u548c\u6297\u80bf\u7624\u751f\u957f\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLR5<\/strong> TLR5\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff0c\u4e14\u80fd\u8bc6\u522b\u7ec6\u83cc\u97ad\u6bdb\u4e2d\u7684\u97ad\u6bdb\u86cb\u767d\u3002\u4e00\u9879\u7814\u7a76\u62a5\u9053\uff0c\u80bf\u7624\u7ec6\u80de\u5f02\u4f4d\u8868\u8fbe\u97ad\u6bdb\u86cb\u767d\u53ef\u8bf1\u5bfc\u53ef\u68c0\u6d4b\u5230\u7684\u9488\u5bf9EL4\u5c0f\u9f20\u6dcb\u5df4\u7624\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u5c06\u97ad\u6bdb\u86cb\u767d\u7528\u4e8e\u80bf\u7624\u75ab\u82d7\u3002\u8fd9\u79cd\u4f5c\u7528\u662f\u901a\u8fc7TLR5\u4fe1\u53f7\u548c\u7531\u6838\u82f7\u9178\u7ed3\u5408\u7684\u5be1\u805a\u5316\u7ed3\u6784\u57df(NOD)\u5305\u542b\u7c7b\u53d7\u4f53(NLR)\u6fc0\u6d3b\u800c\u5f15\u8d77\u7684\u708e\u75c7\u4f53\u6765\u4ecb\u5bfc\u7684\u3002<\/p>\n

\u7136\u800c\uff0c\u6700\u8fd1\u7684\u4e00\u4efd\u62a5\u544a\u8868\u660e\uff0cTLR5\u53ef\u4ee5\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\u3002\u5728TLR5\u7f3a\u9677\u5c0f\u9f20\u7684\u8089\u7624\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u80bf\u7624\u751f\u957f\u53d7\u963b\u3002TLR5 \u7f3a\u9677\u4e0e IL-6 \u8868\u8fbe\u51cf\u5c11\u6709\u5173\uff0cIL-6 \u8868\u8fbe\u51cf\u5c11\u4f1a\u5bfc\u81f4\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff08MDSCs\uff09\u62db\u52df\u51cf\u5c11\uff0cMDSCs \u4f1a\u5bfc\u81f4\u03b3\u03b4-T \u7ec6\u80de\u91ca\u653e galectin-1\uff0c\u4ece\u800c\u6291\u5236\u6297\u80bf\u7624\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u5e76\u52a0\u901f\u80bf\u7624\u8fdb\u5c55\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u4f9d\u8d56\u4e8e TLR5 \u7684\u80bf\u7624\u751f\u957f\u52a0\u901f\u662f\u901a\u8fc7\u4e0e\u5171\u751f\u5fae\u751f\u7269\u7fa4\u7684\u76f8\u4e92\u4f5c\u7528\u4ecb\u5bfc\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLR7\/8 <\/strong>TLR7\u53ef\u8bc6\u522b\u6765\u81eaRNA\u75c5\u6bd2\u7684\u5185\u541e\u4f53\u5185\u7684\u5355\u94feRNA(SsRNA)\u3002\u5b83\u5728\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de(PDC)\u4e0a\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5bf9\u4e8e\u5927\u91cf\u91ca\u653e\u9488\u5bf9\u8fd9\u79cd\u7ec6\u80de\u7c7b\u578b\u7684RNA\u75c5\u6bd2\u7684I\u578bIFN\u6765\u8bf4\u81f3\u5173\u91cd\u8981\u3002\u4eba\u7c7bTLR8\u4e5f\u8bc6\u522b\u75c5\u6bd2\u5355\u94feRNA\u3002\u7136\u800c\uff0cTLR8\u7f3a\u9677\u7684\u5c0f\u9f20\u7ec6\u80de\u5728\u4ea7\u751f\u9488\u5bf9\u75c5\u6bd2\u5355\u94feRNA\u7684\u7ec6\u80de\u56e0\u5b50\u65b9\u9762\u5374\u6ca1\u6709\u7f3a\u9677\u3002TLR7\u8fd8\u53ef\u4ee5\u8bc6\u522b\u4e0e\u81ea\u8eab\u6297\u4f53\u7ed3\u5408\u7684\u81ea\u6211\u884d\u751f\u7684\u5355\u94feRNA\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLR7\/8\u7684\u5c0f\u5206\u5b50\u6fc0\u52a8\u5242\u5df2\u88ab\u63d0\u8bae\u7528\u4f5c\u6297\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u836f\u7269\u3002\u5df2\u77e5\u54aa\u55b9\u83ab\u7279\u901a\u8fc7\u6fc0\u6d3bTLR7-MyD88\u4fe1\u53f7\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u3002\u4e00\u4e9b\u7814\u7a76\u5df2\u7ecf\u9610\u660e\u4e86\u8be5\u5316\u5408\u7269\u6297\u80bf\u7624\u4f5c\u7528\u7684\u8be6\u7ec6\u673a\u5236\u3002<\/p>\n

\u4f8b\u5982\uff0c\u54aa\u55b9\u83ab\u7279\u4f7fDC\u4ea7\u751fI\u578bIFN\uff0c\u5e76\u901a\u8fc7\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53(TRAIL)\u548c\u9897\u7c92\u9176B\u7684\u6d3b\u6027\uff0c\u5c06\u81ea\u5df1\u8f6c\u5316\u4e3a\u80fd\u591f\u76f4\u63a5\u6e05\u9664\u80bf\u7624\u7ec6\u80de\u7684\u7ec6\u80de\u3002<\/p>\n

\u6b64\u5916\uff0c\u5177\u6709\u7279\u5b9a\u5e8f\u5217\u7684\u514d\u75ab\u523a\u6fc0 RNA \u5be1\u6838\u82f7\u9178\u4e5f\u80fd\u4ee5 TLR7 \u4f9d\u8d56\u6027\u65b9\u5f0f\u901a\u8fc7 NK \u7ec6\u80de\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7136\u800c\uff0c\u9057\u4f20\u5b66\u7814\u7a76\u8868\u660e\uff0cTLR7 \u5bf9\u80bf\u7624\u53d1\u751f\u7684\u4f5c\u7528\u6070\u6070\u76f8\u53cd\u3002\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5728\u8868\u8fbe\u7a81\u53d8\u57fa\u56e0K-Ras\u7684\u5c0f\u9f20\u80f0\u817a\u764c\u6a21\u578b\u4e2d\uff0c\u9020\u8840\u7ec6\u80de\u4e2dTLR7\u7684\u7f3a\u4e4f\u4f1a\u963b\u6b62\u80bf\u7624\u7684\u53d1\u5c55\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u5728LLC\u80ba\u764c\u8f6c\u79fb\u6a21\u578b\u4e2d\uff0cTLR7 \u7f3a\u9677\u5c0f\u9f20\u7684\u80bf\u7624\u8d1f\u8377\u8f83\u8f7b\uff0c\u751f\u5b58\u671f\u5ef6\u957f\u3002<\/p>\n

\u4f7f\u7528\u5408\u6210\u914d\u4f53\u7684\u7814\u7a76\u548c\u9057\u4f20\u7814\u7a76\u4e4b\u95f4\u7684\u7ed3\u679c\u4f3c\u4e4e\u4e0d\u4e00\u81f4\uff0c\u56e0\u6b64\u5173\u4e8eTLR7\u4fe1\u53f7\u5bf9\u80bf\u7624\u8fdb\u5c55\u7684\u5f71\u54cd\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u660e\u786e\u7684\u89e3\u91ca\uff1b\u8fd9\u53ef\u80fd\u53d6\u51b3\u4e8e\u5408\u6210\u914d\u4f53\u548c\u5185\u6e90\u6027\u914d\u4f53\u4e4b\u95f4TLR7\u6fc0\u6d3b\u7684\u5e45\u5ea6\u548c\u6301\u7eed\u65f6\u95f4\uff0c\u5176\u4ed6PRRs\u4e5f\u53ef\u80fd\u5982\u6b64(\u89c1\u4e0b\u6587)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLR9 <\/strong>\u5185\u4f53\u4e2d\u7684TLR9\u8bc6\u522b\u672a\u7532\u57fa\u5316\u7684CpG DNA\u57fa\u5e8f\uff0c\u8fd9\u4e9b\u57fa\u5e8f\u7ecf\u5e38\u5728\u75c5\u6bd2\u548c\u7ec6\u83cc\u57fa\u56e0\u7ec4\u4e2d\u88ab\u53d1\u73b0\u3002TLR9 \u8fd8\u80fd\u4ee5\u7c7b\u4f3c\u4e8e TLR7 \u7684\u65b9\u5f0f\u8bc6\u522b\u4e0e\u81ea\u8eab\u6297\u4f53\u7ed3\u5408\u7684\u81ea\u8eab DNA\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

TLR9\u4fe1\u53f7\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u4f5c\u7528\u5df2\u88ab\u5927\u91cf\u62a5\u9053\u6240\u5f3a\u8c03\u3002<\/p>\n

\u6700\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cTLR9\u914d\u4f53CpG-\u5be1\u6838\u82f7\u9178(CpG-ODN)\u5bf9\u80bf\u7624\u751f\u957f\u7684\u6cbb\u7597\u4f5c\u7528\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002CpG-ODN\u5728\u6cbb\u7597C3\u5c0f\u9f20\u5bab\u9888\u764c\u6a21\u578b\u548cC26\u5c0f\u9f20\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\u8bf1\u5bfc\u4e86\u663e\u8457\u7684\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u8fd9\u79cd\u6cbb\u7597\u6240\u5bfc\u81f4\u7684\u80bf\u7624\u6d88\u9000\u548c\u5ef6\u957f\u751f\u5b58\u9700\u8981CD8+<\/sup>T\u7ec6\u80de\u7684\u53c2\u4e0e\u3002<\/p>\n

CpG-ODN\u5bf9\u5c0f\u9f20\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\u682aNeur2a\u4e5f\u6709\u6291\u5236\u4f5c\u7528\uff0c\u8fd9\u4f3c\u4e4e\u662f\u7531NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u3002<\/p>\n

\u6b64\u5916\uff0c\u5728\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u5c06\u53e6\u4e00\u79cd\u523a\u6fc0 TLR9 \u7684 ODN \u4e0e\u66f2\u59a5\u73e0\u5355\u6297\uff08\u4e00\u79cd\u6297\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 2\uff08HER2\uff09\u7684\u5355\u514b\u9686\u6297\u4f53\uff09\u7ed3\u5408\u4f7f\u7528\uff0c\u53ef\u6709\u6548\u63a7\u5236\u5bf9\u66f2\u59a5\u73e0\u5355\u6297\u8010\u836f\u7684\u4eba\u7c7b\u4e73\u817a\u764c\u7ec6\u80de\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u79cdODN\u5728\u819c\u6c34\u5e73\u4e0a\u8c03\u8282\u4e86TLR9\u4e0eHER\u53d7\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u6291\u5236HER\u6240\u4f9d\u8d56\u7684\u751f\u957f\u4fe1\u53f7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u65b9\u9762\uff0cTLR9\u53ef\u80fd\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002\u4e0eWT\u5c0f\u9f20\u76f8\u6bd4\uff0c\u539f\u4f4d\u79fb\u690d\u643a\u5e26K-RAS\u548cP53\u7a81\u53d8\u57fa\u56e0\u7684\u80f0\u817a\u764c\u7ec6\u80de\u5728TLR9\u7f3a\u9677\u5c0f\u9f20\u4e2d\u663e\u793a\u51fa\u751f\u957f\u5ef6\u8fdf\u3002\u8fd9\u79cd\u6548\u5e94\u662f\u80f0\u817aTME\u7279\u6709\u7684\uff0c\u56e0\u4e3a\u5728TLR9\u7f3a\u9677\u5c0f\u9f20\u4e2d\uff0c\u76ae\u4e0b\u79fb\u690d\u7684\u80f0\u817a\u7ec6\u80de\u6ca1\u6709\u663e\u793a\u51fa\u751f\u957f\u51cf\u5c11\u3002<\/p>\n

\u5728\u673a\u5236\u4e0a\uff0cTLR9\u6fc0\u6d3b\u80f0\u817a\u661f\u72b6\u7ec6\u80de(PSCs)\u5bfc\u81f4\u8d8b\u5316\u56e0\u5b50(C-C\u57fa\u5e8f)\u914d\u4f5311(CCL11)\u7684\u4ea7\u751f\uff0c\u901a\u8fc7\u5176\u53d7\u4f53\u8d8b\u5316\u56e0\u5b50(C-C\u57fa\u5e8f)\u53d7\u4f533(CCR3)\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u3002<\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u8868\u660e\uff0cPSCs\u53ef\u80fd\u662f\u901a\u8fc7CCL3-CCR5\u8f74\u5c06\u8c03\u8282\u6027T\u7ec6\u80de(Tregs)\u4ee5\u4f9d\u8d56TLR9\u7684\u65b9\u5f0f\u52df\u96c6\u5230\u80bf\u7624\u5468\u56f4\u90e8\u4f4d\u3002\u6b64\u5916\uff0c\u514d\u75ab\u7ec6\u80de\u4e2d\u7684 TLR9 \u4e5f\u4f1a\u5c06 MDSC \u62db\u52df\u5230\u80bf\u7624\u7ec4\u7ec7\u3001\u5668\u5b98\u548c\u7ec4\u7ec7\u4e2d\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u52a0\u5267\u80bf\u7624\u7684\u8fdb\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

25.1.2 \u7ec6\u80de\u8d28\u6838\u9178\u611f\u5e94\u5668\u5728\u80bf\u7624\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528<\/p>\n<\/section>\n

\n
\n
\n

\u80de\u8d28\u6838\u9178\u611f\u5e94\u5668PRRs\u51e0\u4e4e\u5728\u6240\u6709\u7c7b\u578b\u7684\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5e76\u901a\u8fc7\u68c0\u6d4bRNA\u548cDNA\u6216\u5b83\u4eec\u7684\u6a21\u62df\u7269\u6765\u6fc0\u53d1\u5148\u5929\u6027\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e9b\u80de\u8d28PRRs\u6fc0\u6d3b\u7684\u6807\u5fd7\u662fI\u578bIFNs\u7684\u8bf1\u5bfc\uff0c\u8fd9\u79cd\u8bf1\u5bfc\u662f PRRs \u8bc6\u522b\u75c5\u6bd2\u884d\u751f\u6838\u9178\u4ece\u800c\u4ea7\u751f\u6709\u6548\u6297\u75c5\u6bd2\u53cd\u5e94\u7684\u57fa\u7840 \u3002\u7531\u4e8eI\u578bIFNs\u7684\u6297\u80bf\u7624\u529f\u80fd\u5df2\u88ab\u5e7f\u6cdb\u8ba4\u8bc6\uff0c\u8fd9\u4e9bPRRs\u53d7\u4f53\u5728\u6297\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u4f5c\u7528\u4e5f\u4e00\u76f4\u662f\u4eba\u4eec\u5173\u6ce8\u7684\u7126\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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RLRs <\/strong>RIG-I(\u4e5f\u79f0\u4e3aDDX58)\u548c\u9ed1\u8272\u7d20\u7624\u5206\u5316\u76f8\u5173\u57fa\u56e05(MDA5)\u80fd\u611f\u77e5 RNA \u75c5\u6bd2\u7684\u590d\u5236\u4e2d\u95f4\u4f53 dsRNA\uff0c\u4ece\u800c\u5728\u611f\u67d3\u7ec6\u80de\u4e2d\u4ea7\u751f\u5927\u91cf I \u578b IFNs\u3002<\/p>\n

\u8be5\u5bb6\u65cf\u7684\u53e6\u4e00\u4e2a\u6210\u5458–LGP2\u4f5c\u4e3aRIG-I\u548cMDA-5\u7684\u8d1f\u53cd\u9988\u8c03\u8282\u56e0\u5b50\uff0c\u4f46\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u80fd\u4fc3\u8fdbMDA5\u4fe1\u53f7\u901a\u8def\u3002\u5c3d\u7ba1\u8fd9\u4e24\u79cd\u6fc0\u6d3b\u578b\u7684PRRs\u5728\u603b\u4f53\u7ed3\u6784\u4e0a\u76f8\u4f3c\uff0c\u4f46\u7531\u4e8e\u75c5\u6bd2\u884d\u751f RNA \u7684\u7ed3\u6784\u7279\u5f81\u4e0d\u540c\uff0c\u5b83\u4eec\u68c0\u6d4b\u7684\u75c5\u6bd2\u79cd\u7c7b\u4e5f\u4e0d\u540c\u3002RIG-I \u4e0e\u542b\u6709 5\u2032-\u4e09\u78f7\u9178\u7684 ssRNA\uff08\u5982\u75c5\u6bd2 RNA \u548c\u4f53\u5916\u8f6c\u5f55\u7684 dsRNA\uff09\u7279\u5f02\u6027\u7ed3\u5408\u3002<\/p>\n

\u7814\u7a76\u8fd8\u8868\u660e\uff0cRIG-I \u4f18\u5148\u4e0e\u77ed dsRNA \u7ed3\u5408\uff0c\u800c MDA5 \u5219\u4f18\u5148\u8bc6\u522b\u957f dsRNA\u3002\u8fd9\u4e24\u79cd RLR \u5177\u6709\u5171\u540c\u7684\u4fe1\u53f7\u7279\u5f81\u3002\u8bc6\u522b\u5230 dsRNA \u540e\uff0c\u5b83\u4eec\u4f1a\u88ab\u9002\u914d\u4f53 MAVS\uff08\u53c8\u79f0 IPS-1\u3001CARDIF \u6216 VISA\uff09\u62db\u52df\u5230\u7ebf\u7c92\u4f53\u5916\u819c\uff0c\u4ece\u800c\u6fc0\u6d3b\u591a\u4e2a\u8f6c\u5f55\u56e0\u5b50\uff0c\u5305\u62ec IRF3\u3001IRF7 \u548c NF-\u03baB\u3002IRF3 \u548c IRF7 \u4e3b\u8981\u4ecb\u5bfc I \u578b IFNs \u7684\u8bf1\u5bfc\uff0c\u800c NF-\u03baB \u5219\u8c03\u8282\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u57fa\u56e0\u8bf1\u5bfc\uff08\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u53c2\u9605 “\u7ec6\u80de\u56e0\u5b50 “\u4e00\u8282\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9bRLRs\u7684\u6fc0\u6d3b\u5f3a\u52b2\u8bf1\u5bfc\u4e86I\u578bIFN\uff0c\u4fc3\u4f7f\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u5b83\u4eec\u5728\u6297\u80bf\u7624\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\uff0c\u56e0\u4e3aI\u578bIFN\u53ef\u8c03\u8282\u6297\u75c5\u6bd2\u53cd\u5e94\u4e4b\u5916\u7684\u5305\u62ec\u5bf9\u7ec6\u80de\u751f\u957f\u3001\u5206\u5316\u548c\u6297\u80bf\u7624\u514d\u75ab\u7684\u5f71\u54cd\u7b49\u8bb8\u591a\u91cd\u8981\u7684\u7ec6\u80de\u529f\u80fd\u3002<\/p>\n

\u5728\u4eba\u7c7b\u809d\u764c\u7ec4\u7ec7\u4e2dRIG-I\u7684\u4f4e\u8868\u8fbe\u9884\u793a\u7740\u66f4\u5dee\u7684\u9884\u540e\u548c\u5bf9\u5e72\u6270\u7d20-\u03b1\u6cbb\u7597\u7684\u66f4\u9ad8\u62b5\u6297\u529b\u3002RIG-I\u7684\u80bf\u7624\u6291\u5236\u4f5c\u7528\u5df2\u5728RIG-I\u7f3a\u9677\u5c0f\u9f20\u7684\u809d\u764c\u6a21\u578b\u4e2d\u5f97\u5230\u9a8c\u8bc1\u3002\u53e6\u6709\u62a5\u9053\u79f0\uff0cRIG-I\u6fc0\u6d3b\u53ef\u8bf1\u5bfc\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u5206\u6ccc\u7ec6\u80de\u5916\u56ca\u6ce1(EV)\uff0c\u5e76\u5728\u5176\u8868\u9762\u8868\u8fbeNKp30\u914d\u4f53\uff0c\u4ece\u800c\u89e6\u53d1NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u5bf9\u5176\u7684\u6e05\u9664\u3002<\/p>\n

\u7531\u4e8e MDA5 \u89e6\u53d1\u4e86\u4e0e RIG-I \u7c7b\u4f3c\u751a\u81f3\u76f8\u540c\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u8fd9\u76f4\u63a5\u610f\u5473\u7740 MDA5 \u4e5f\u53c2\u4e0e\u4e86\u80bf\u7624\u7684\u53d1\u5c55\u3002<\/p>\n

\u7531\u4e8eLGP2\u589e\u5f3a\u4e86CD8+T\u7ec6\u80de\u7684\u5b58\u6d3b\u548c\u6fc0\u6d3b\uff0c\u56e0\u6b64LGP2\u4e5f\u53ef\u80fd\u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u53d1\u6325\u76f4\u63a5\u8c03\u8282\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u4e8b\u5b9e\u4e0a\uff0cRIG-I \u7684\u6fc0\u6d3b\u8fd8\u80fd\u901a\u8fc7 BH3 \u5bb6\u65cf\u8bf1\u5bfc\u7ec6\u80de\u5185\u5728\u51cb\u4ea1\uff0c\u800c\u8fd9\u79cd\u51cb\u4ea1\u4e0e I \u578b IFN \u4fe1\u53f7\u4f20\u5bfc\u65e0\u5173\uff0c\u56e0\u6b64\u4eba\u4eec\u5f00\u59cb\u7814\u7a76\u5982\u4f55\u5229\u7528 RIG-I \u4ecb\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u6765\u9009\u62e9\u6027\u5730\u6d88\u706d\u6076\u6027\u7ec6\u80de \u3002<\/p>\n

\u56e0\u6b64\uff0c\u4eba\u4eec\u81f4\u529b\u4e8e\u5f00\u53d1 RLR \u4fe1\u53f7\u901a\u8def\u7684\u9776\u5411\u836f\u7269\uff0c\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u5176\u5de5\u4f5c\u5047\u8bbe\u662f\uff0cI \u578b IFN\u3001\u7ec6\u80de\u51cb\u4ea1\u6216\u8fd9\u4e24\u79cd\u901a\u8def\u7684\u8bf1\u5bfc\u53ef\u80fd\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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DNA\u611f\u5e94\u5668 <\/strong>\u5728\u8fc4\u4eca\u62a5\u9053\u7684DNA\u611f\u5e94PRRs\u4e2d\uff0c\u73afGMP-AMP\uff08cGAMP\uff09\u5408\u6210\u9176\uff08cGAS\uff09\u5728\u6297\u75c5\u6bd2\u514d\u75ab\u4e2d\u7684\u4f5c\u7528\u662f\u7279\u5f81\u6700\u660e\u663e\u7684\u5206\u5b50\u4e4b\u4e00\u3002\u91ca\u653e\u5230\u7ec6\u80de\u8d28\u4e2d\u7684\u75c5\u6bd2 DNA \u5728 cGAS \u50ac\u5316\u4e0b\u8f6c\u5316\u4e3a cGAMP\uff0ccGAMP \u53cd\u8fc7\u6765\u53c8\u4e0e IFN \u57fa\u56e0\u523a\u6fc0\u56e0\u5b50\uff08STING\uff09\u7ed3\u5408\uff0c\u6fc0\u6d3b\u5176\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff0c\u5305\u62ec I \u578b IFNs \u3002<\/p>\n

\u4e00\u4e9b\u7814\u7a76\u8868\u660ecGAS\u53c2\u4e0e\u4e86\u5bbf\u4e3b\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8868\u8fbecGAS\u7684\u5de8\u566c\u7ec6\u80de\u5bf9\u4e8e\u80bf\u7624\u6765\u6e90\u7684\u03b2\u53cd\u5e94\u4ea7\u751f\u5e72\u6270\u7d20-DNA\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\u3002\u4e0e\u6b64\u4e00\u81f4\u7684\u662f\uff0c\u7167\u5c04\u7684\u80bf\u7624\u7ec6\u80de\u523a\u6fc0DC\u91ca\u653eIFN-\u03b2\uff0c\u4ee5cGAS\u4f9d\u8d56\u7684\u65b9\u5f0f\u4fc3\u8fdb\u6297\u539f\u7279\u5f02\u6027CD8+<\/sup>T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002<\/p>\n

\u6b64\u5916\uff0c\u6297\u764c\u836f\u7269\u987a\u94c2\u548c\u559c\u6811\u78b1\u4e5f\u9700\u8981 cGAS \u624d\u80fd\u89e6\u53d1 IFN-\u03b2 \u7684\u4ea7\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86cGAS\u4ecb\u5bfc\u7684\u9014\u5f84\u5916\uff0c\u5176\u4ed6DNA\u4f20\u611f\u673a\u5236\u5bf9\u4e8e\u80de\u8d28\u6838\u9178\u7684\u53cd\u5e94\u4e5f\u5f88\u91cd\u8981\u3002<\/p>\n

DNA\u4f9d\u8d56\u7684IRFs\u6fc0\u6d3b\u5242(DAI)\u4e0eTBK1\u548cIRF3\u7ed3\u5408\u5e76\u5e94\u7b54\u80de\u5185DNA\uff0c\u8bf1\u5bfcI\u578bIFN\uff0c\u5176\u6297\u80bf\u7624\u4f5c\u7528\u5df2\u88ab\u62a5\u9053\u3002\u53e6\u4e00\u79cdDNA\u4f20\u611f\u7684PRR–\u4eba\u7684IFN-\u03b3\u8bf1\u5bfc\u86cb\u767d16(IFI16)\u53ca\u5176\u5c0f\u9f20\u540c\u6e90\u57fa\u56e0p206\u5728\u80de\u6d46DNA\u523a\u6fc0\u4e0b\u8bf1\u5bfcIRF3\u6fc0\u6d3b\u548cIFN-\u03b2\u7684\u4ea7\u751f\uff0c\u5176\u4e2dSTING\u5230IFI16\u7684\u52df\u96c6\u53ef\u80fd\u662f\u4fe1\u53f7\u901a\u8def\u4e2d\u7684\u5173\u952e\u6b65\u9aa4\u3002<\/p>\n

\u53e6\u4e00\u79cdPRR-DDX41\u4e5f\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u4e0eSTING\u4e4b\u95f4\u7684\u5173\u8054\u3002DDX41\u8bc6\u522b\u591a\u79cdDNA\uff0c\u5e76\u4f5c\u4e3acGAMP\u7684\u7b2c\u4e8c\u4fe1\u4f7f\u76f4\u63a5\u611f\u5e94cGAMP-di-GMP\u548ccGAMP\u3002\u5df2\u6709\u62a5\u9053\u79f0\u5728\u7531 DDX41 \u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\u9020\u8840\u80bf\u7624\u4e2d\uff0cDDX41 \u5177\u6709\u6291\u5236\u80bf\u7624\u7684\u4f5c\u7528 \u3002<\/p>\n

\u6b64\u5916\uff0c\u4e00\u4e9bDNA\u635f\u4f24\u53cd\u5e94\u5206\u5b50\uff0c\u5982DNA\u4f9d\u8d56\u7684\u86cb\u767d\u6fc0\u9176(DNA-PK)\u548c\u51cf\u6570\u5206\u88c2\u91cd\u7ec411(Mre11)\uff0c\u53c2\u4e0e\u4e86\u80de\u8d28DNA\u4f20\u611f\uff1b\u7136\u800c\u5c1a\u4e0d\u6e05\u695a\u8fd9\u4e9bDNA\u4f20\u611f\u5668\u662f\u5426\u8c03\u63a7\u80bf\u7624\u7684\u53d1\u5c55\u3002<\/p>\n

\u603b\u4f53\u800c\u8a00\uff0c\u7531\u4e8e\u80bf\u7624\u6765\u6e90\u7684DNA\u88abTME\u4e2d\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de\u6444\u53d6\u5e76\u6fc0\u6d3bDNA\u4f20\u611f\u7684PRRs\uff0c\u5176\u6297\u80bf\u7624\u529f\u80fd\u4e00\u76f4\u662f\u57fa\u7840\u548c\u4e34\u5e8a\u764c\u75c7\u514d\u75ab\u5b66\u5173\u6ce8\u7684\u7126\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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STING<\/strong>\uff08\u5e72\u6270\u7d20\u57fa\u56e0\u523a\u6fc0\u56e0\u5b50\uff0cstimulator of interferon genes, STING\uff09\u5728\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u4f5c\u7528\u4e00\u76f4\u662f\u4eba\u4eec\u7279\u522b\u5173\u6ce8\u7684\u7126\u70b9\u3002<\/p>\n

\u5728\u63a5\u79cd\u4e86\u8868\u8fbe\u514d\u75ab\u539f\u80bd\u7684\u80bf\u7624\u7ec6\u80de\u7684\u5c0f\u9f20\u4e2d\uff0cSTING\u4f3c\u4e4e\u6709\u52a9\u4e8e\u5bf9\u8fd9\u4e9b\u7ec6\u80de\u7684\u6297\u80bf\u7624\u53cd\u5e94\uff0c\u5176\u4e2d\u80bf\u7624\u6765\u6e90\u7684DNA\u88abTME\u4e2d\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de\u6444\u53d6\uff0c\u523a\u6fc0STING\u5e76\u8bf1\u5bfcIRF3\u4ecb\u5bfc\u7684IFN-\u03b2\u7684\u4ea7\u751f\uff0c\u4ee5\u6269\u589e\u6297\u539f\u7279\u5f02\u6027CD8+T\u7ec6\u80de\u3002<\/p>\n

\u7c7b\u4f3c\u5730\uff0c\u653e\u5c04\u6cbb\u7597\u7684\u80bf\u7624\u4e5f\u4f1a\u89e6\u53d1STING\u4f9d\u8d56\u6027\u7684IFN-\u03b2\u7684\u4ea7\u751f\u548cCD8+T\u7ec6\u80de\u7684\u6fc0\u6d3b\u3002\u8fd9\u8868\u660e\u4e86\uff0c\u8fd9\u79cdIFN-\u03b2\u7684\u4e0a\u8c03\u662f\u7531\u6b7b\u4ea1\u7ec6\u80de\u4ea7\u751f\u7684DNA\u901a\u8fc7\u6fc0\u6d3bIRF3\u8bf1\u5bfc\u7684\u3002<\/p>\n

\u6b64\u5916\uff0cSTING\u4fc3\u8fdb\u80bf\u7624\u7ec4\u7ec7\u4e2dIL-18\u548cIL22BP\u7684\u8868\u8fbe\uff0c\u5e76\u6291\u5236AOM\/DSS\u7ed3\u80a0\u764c\u7684\u53d1\u751f\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u636e\u62a5\u9053\uff0cSTING\u4fe1\u53f7\u901a\u8def\u53ef\u4ee5\u4e0b\u8c03\u4fc3\u708e\u56e0\u5b50IL-6\u7684\u8868\u8fbe\uff0c\u800cIL-6\u53ef\u6fc0\u6d3b\u4fc3\u80bf\u7624\u8f6c\u5f55\u56e0\u5b50STAT3\u3002<\/p>\n

\u4e00\u9879\u4f7f\u7528\u80f6\u8d28\u7624\u6a21\u578b\u7684\u7814\u7a76\u8868\u660e\uff0cSTING\u901a\u8fc7\u589e\u5f3aCD8+T\u7ec6\u80de\u7684\u6d3b\u6027\u548c\u51cf\u5c11\u514d\u75ab\u6291\u5236\u7ec6\u80de(\u5982MDSCs\u548cTregs)\u5728\u5927\u8111\u4e2d\u7684\u6d78\u6da6\u6765\u51cf\u8f7b\u76f8\u5173\u7684\u764c\u75c7\u8d1f\u62c5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u603b\u7684\u6765\u8bf4\uff0c\u9776\u5411\u6fc0\u6d3b\u7684STING\u5728\u8bb8\u591a\u5c0f\u9f20\u6a21\u578b\u4e2d\u5bf9\u764c\u75c7\u7684\u6cbb\u7597\u662f\u6709\u76ca\u7684\u3002\u7ed9\u4e88cGAMP\u53ef\u51cf\u5c11\u7ed3\u80a0\u764c26\u7ec6\u80de\u7684\u80bf\u7624\u751f\u957f\uff0c\u4e0eDC\u6210\u719f\u6709\u5173\u3002<\/p>\n

\u6b64\u5916\uff0ccGAMP\u8fd8\u901a\u8fc7I\u578bIFN\u4fe1\u53f7\u9014\u5f84\u6fc0\u6d3bTME\uff08\u80bf\u7624\u5fae\u73af\u5883\uff09\u4e2d\u7684CD8+<\/sup>T\u7ec6\u80de\uff0c\u4ece\u800c\u6291\u5236\u4f53\u5185B16\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7531\u5316\u5408\u7269ML RR-S2\u6fc0\u6d3b\u7684STING\u53ef\u4ee5\u5728\u51e0\u79cd\u5c0f\u9f20\u6a21\u578b\u4e2d\u53d1\u6325\u6297\u80bf\u7624\u6d3b\u6027\u3002ML RR-S2\u5728\u5b9e\u9a8c\u4e0a\u4e5f\u53ef\u7528\u4f5cGM-CSF\u8868\u8fbe\u7684\u6b7b\u4ea1\u80bf\u7624\u7ec6\u80de\u6297\u764c\u75ab\u82d7\u7684\u4f50\u5242\u3002\u8fd9\u79cd\u6cbb\u7597\u7b56\u7565\u88ab\u79f0\u4e3a STINGVAX\uff0c\u5df2\u88ab\u8bc1\u660e\u5bf9\u68c0\u67e5\u70b9\u7597\u6cd5\u8010\u836f\u7684 B16 \u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u6709\u6548\u3002<\/p>\n

\u4e0e\u6b64\u76f8\u5173\uff0c\u5728\u8fd9\u65b9\u9762\u4e5f\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e00\u4e9b\u6297\u764c\u5316\u5b66\u836f\u7269\u4e5f\u662fDNA\u52a0\u5408\u7269\u5f62\u6210\u5242\uff0c\u89e6\u53d1\u7ec6\u80de\u6b7b\u4ea1\u5e76\u91ca\u653eSTING\u6fc0\u52a8\u5242\u3002\u5df2\u53d1\u73b05\uff0c6-\u4e8c\u7532\u57fa\u9ec4\u539f\u916e-4-\u918b\u9178(DMXAA)\u662f\u4e00\u79cd\u8840\u7ba1\u5e72\u6270\u5242\uff0c\u53ef\u76f4\u63a5\u4e0eSTING\u7ed3\u5408\uff0c\u73b0\u5df2\u88ab\u7528\u4f5cSTING\u6fc0\u52a8\u5242\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u3002DMXAA\u8bf1\u5bfc\u6297\u539f\u63d0\u5448\u7ec6\u80de\u4ea7\u751fIFN\u03b2\uff0c\u5e76\u901a\u8fc7\u589e\u5f3a\u83b7\u5f97\u6027\u514d\u75ab\u5bf9\u4f53\u5185\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u663e\u793a\u51fa\u5f3a\u5927\u7684\u6cbb\u7597\u6d3b\u6027\u3002<\/p>\n

\u6b64\u5916\uff0cDMXAA \u8fd8\u80fd\u9776\u5411\u5de8\u566c\u7ec6\u80de\uff0c\u5e76\u5c06\u5176\u4ece M2 \u578b\u6781\u5316\u4e3a M1 \u578b\u3002DMXAA\u6cbb\u7597\u4fc3\u8fdb\u4e86\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u8bb0\u5fc6\uff0c\u901a\u8fc7DMXAA\u6cbb\u7597\u800c\u83b7\u5f97\u4e86\u6392\u65a5\u67d0\u79cd\u80bf\u7624\u6548\u5e94\u7684\u5c0f\u9f20\u5bf9\u7ee7\u53d1\u6027\u80bf\u7624\u540c\u6837\u5177\u6709\u62b5\u6297\u529b\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u79cd\u836f\u7269\u7684\u7624\u5185\u7ed9\u836f\u6291\u5236\u4e86\u5176\u4ed6\u8fdc\u5904\u90e8\u4f4d\u7684\u80bf\u7624\u751f\u957f\u3002\u56e0\u6b64\uff0cSTING\u6fc0\u6d3b\u5206\u5b50\uff0c\u5982\u80de\u6d46\u73af\u4e8c\u6838\u82f7\u9178\u548c\u5316\u5b66\u5316\u5408\u7269\uff0c\u53ef\u80fd\u4e3a\u5efa\u7acb\u6709\u6548\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u94fa\u5e73\u9053\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u65b9\u9762\uff0c\u6709\u62a5\u9053\u663e\u793aSTING\u5177\u6709\u4fc3\u80bf\u7624\u4f5c\u7528\u3002\u5728\u81f4\u764c\u7269\u635f\u4f24\u7684\u7ec6\u80de\u4e2d\uff0cDNA\u91ca\u653e\u5230\u80de\u6d46\u4e2d\u4f1a\u523a\u6fc0STING\u8bf1\u5bfc\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u8868\u8fbe\uff0c\u5e76\u52a0\u5267DMBA\u8bf1\u5bfc\u7684\u76ae\u80a4\u764c\u3002<\/p>\n

\u4e5f\u6709\u62a5\u9053\u79f0\uff0c\u514d\u75ab\u6291\u5236\u5bbf\u4e3b\u4f53\u5185\u7684STING\u53ef\u4fc3\u8fdbLLC\u80bf\u7624\u7ec6\u80de\u7684\u76ae\u5185\u751f\u957f\u548c\u80ba\u8f6c\u79fb\u3002\u8fd9\u9879\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u9488\u5bf9gp100\u8f6c\u5bfc\u7684LLC\u7ec6\u80de\u7684\u6297\u80bf\u7624\u53cd\u5e94\u662f\u4ee5STING\u4f9d\u8d56\u7684\u65b9\u5f0f\u8bf1\u5bfc\u7684\uff0c\u8fd9\u610f\u5473\u7740STING\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u6216\u4fc3\u80bf\u7624\u53cd\u5e94\u4f9d\u8d56\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Sho Hangai, Yoshitaka Kimura,Tadatsugu Taniguchi, and Hideyuki Yanai<\/span><\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u6e29\u946b<\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u5415\u601d\u8d24<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

25.1 \u5f15\u8a00 \u764c\u75c7\u514d\u75ab\u76d1\u89c6\uff0c\u5373\u514d\u75ab\u7cfb\u7edf\u641c\u7d22\u5e76\u8bc6\u522b\u4f53\u5185\u764c\u75c7\u548c\u764c\u7ec6\u80de\u7684\u8fc7\u7a0b\uff0c\u5176\u5386\u53f2\u53ef\u4ee5\u8ffd\u6eaf\u523020\u4e16\u7eaa\u521d…<\/p>\n","protected":false},"author":1,"featured_media":3560,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3562"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3562"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3562\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3560"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3562"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}