{"id":3564,"date":"2023-11-28T07:25:58","date_gmt":"2023-11-27T23:25:58","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2023\/11\/28\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac25%e7%ab%a0%ef%bc%9a%e5%85%88%e5%a4%a9%e5%85%8d%e7%96%ab%e5%8f%97%e4%bd%93%e5%9c%a8%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82-2\/"},"modified":"2023-11-28T07:25:58","modified_gmt":"2023-11-27T23:25:58","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac25%e7%ab%a0%ef%bc%9a%e5%85%88%e5%a4%a9%e5%85%8d%e7%96%ab%e5%8f%97%e4%bd%93%e5%9c%a8%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82-2","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2023\/11\/28\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac25%e7%ab%a0%ef%bc%9a%e5%85%88%e5%a4%a9%e5%85%8d%e7%96%ab%e5%8f%97%e4%bd%93%e5%9c%a8%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%b0%83%e8%8a%82-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c25\u7ae0\uff1a\u5148\u5929\u514d\u75ab\u53d7\u4f53\u5728\u80bf\u7624\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c25\u7ae0\uff1a\u5148\u5929\u514d\u75ab\u53d7\u4f53\u5728\u80bf\u7624\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\uff08\u4e0a\uff09<\/span><\/a>\u200b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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OncoLab\u516c\u4f17\u53f7\u5df2\u589e\u52a0\u671f\u520a\u67e5\u8be2\u529f\u80fd<\/span><\/strong>\uff0cSCI\u671f\u520a<\/strong><\/span>\u53ef\u67e5\u8be2\u671f\u520a\u540d\u79f0\u7f29\u5199\u3001ISSN\u520a\u53f7\u3001\u8fd1\u4e94\u5e74\u5f71\u54cd\u56e0\u5b50<\/strong>\u3001\u6700\u65b0WOS\u7684JCR\u5206\u533a<\/strong>\u3001\u6700\u65b0\u4e2d\u79d1\u9662\u5206\u533a<\/strong>\u4ee5\u53ca\u4e2d\u79d1\u9662\u671f\u520a\u9884\u8b66\u4fe1\u606f<\/strong>\uff1b<\/p>\n

\u4e2d\u6587\u671f\u520a<\/span><\/strong>\u53ef\u68c0\u7d22CSCD\u6838\u5fc3<\/strong>\u3001\u5317\u5927\u4e2d\u6587\u6838\u5fc3<\/strong>\u3001\u79d1\u6280\u6838\u5fc3<\/strong>\u6536\u5f55\u60c5\u51b5\uff1b<\/p>\n

\u5728\u516c\u4f17\u53f7\u5bf9\u8bdd\u6846\u53d1\u9001\u6742\u5fd7\u540d\u79f0<\/span><\/strong>\u5373\u53ef\u5feb\u901f\u68c0\u7d22\uff0c\u652f\u6301\u6a21\u7cca\u68c0\u7d22\uff0c\u6b22\u8fce\u4f7f\u7528\uff01<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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25.1.3 C\u578b\u51dd\u96c6\u7d20\u53d7\u4f53\uff08CLRs)\u5728\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528<\/p>\n<\/section>\n

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CLR\u5bb6\u65cf\u6210\u5458\u7684\u4e3b\u8981\u7279\u5f81\u662f\u68c0\u6d4b\u7ec6\u83cc\u3001\u771f\u83cc\u548c\u75c5\u6bd2\u4e0a\u7684\u78b3\u6c34\u5316\u5408\u7269\uff0c\u6709\u4e9b CLR \u8fd8\u80fd\u8bc6\u522b\u6c27\u5316\u8102\u8d28\u548c\u53d7\u635f\u7ec6\u80de\u66b4\u9732\u7684\u5176\u4ed6\u635f\u4f24\u76f8\u5173\u5206\u5b50\u6a21\u5f0f (damage-associated\u2006molecular\u2006pattern, DAMP\uff09\u5206\u5b50\u3002<\/p>\n

CLR\u6fc0\u6d3b\u5bfc\u81f4\u514d\u75ab\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u6d3b\u57fa\u5e8f(ITAM)\/\u514d\u75ab\u53d7\u4f53\u916a\u6c28\u9178\u6291\u5236\u57fa\u5e8f(ITIM)\u4f9d\u8d56\u6216ITIM\u975e\u4f9d\u8d56\u7684\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u4ee5\u8bf1\u5bfc\u5bbf\u4e3b\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u4e00\u4e9b\u57fa\u4e8eITAM\u7684CLR\uff0c\u5982Dectin-1\u548cC\u578b\u51dd\u96c6\u7d20\u7ed3\u6784\u57df\u5bb6\u65cf2(CLEC-2)\uff0c\u5177\u6709hemITAM\u57fa\u5e8f\uff0c\u5e76\u901a\u8fc7caspase\u6fc0\u6d3b\u548c\u52df\u96c6\u7ed3\u6784\u57df9(CARD9) \u62db\u52df\u813e\u916a\u6c28\u9178\u6fc0\u9176(Syk)\u6765\u6fc0\u6d3bNF-\u03baB\u3002Syk\u8fdb\u4e00\u6b65\u8f6c\u5bfcMAPK\u548c\u6d3b\u5316T\u7ec6\u80de\u6838\u56e0\u5b50(NFAT)\u9014\u5f84\uff0c\u5e76\u8bf1\u5bfc\u4ea7\u751f\u6709\u52a9\u4e8eNACHT\u3001LRR\u548cPYD\u7ed3\u6784\u57df\u5305\u542b\u86cb\u767d3(NALP3)\u6fc0\u6d3b\u3002<\/p>\n

\u5176\u4ed6\u7684\u4ee5Dectin-2\u3001Mincle\u548c\u5de8\u566c\u7ec6\u80deC\u578b\u51dd\u96c6\u7d20(MCL)\u4e3a\u4ee3\u8868\u7684\u57fa\u4e8eITAM\u7684CLR\u4e0e\u542b\u6709ITAM\u7684\u63a5\u5934\u86cb\u767d\uff0c\u5982Fc\u53d7\u4f53\u03b3(FcR\u03b3)\u94fe\u7ed3\u5408\uff0c\u5bfc\u81f4Syk\u4f9d\u8d56\u7684\u4fe1\u53f7\u8f6c\u5bfc\u3002\u542bITIM\u7684CLRs\u901a\u8fc7Src-\u540c\u6e902\u542b\u7ed3\u6784\u57df\u7684\u78f7\u9178\u9176-1(SHP-1)\u548cSHP-2\u6291\u5236NF-\u03baB \u548c STAT5\u7684\u6fc0\u6d3b\u4ee5\u53ca\u57fa\u4e8eITAM\u7684\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n

\u9664\u4e86\u4fe1\u53f7\u8f6c\u5bfc\uff0cCLRs\u8fd8\u9a71\u52a8\u9ad3\u7cfb\u7ec6\u80de\u7684\u541e\u566c\u7cfb\u7edf\uff0c\u4fc3\u8fdb\u5165\u4fb5\u7684\u75c5\u539f\u4f53\u548c\u5f02\u5e38\u7684\u81ea\u4f53\u5206\u5b50\u7684\u6444\u53d6\u3002\u901a\u8fc7\u8fd9\u4e9b\u673a\u5236\uff0cCLRs\u5728\u8c03\u8282\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u548c\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CLR\u5728\u80bf\u7624\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u5c1a\u672a\u5f97\u5230\u6df1\u5165\u5206\u6790\u3002\u6700\u8fd1\u7684\u4e00\u4e9b\u7814\u7a76\u8868\u660e\uff0cCLRs\u63a7\u5236\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\uff0c\u4f5c\u4e3a\u5173\u952e\u7684\u5148\u5929\u53d7\u4f53\uff0c\u89e6\u53d1\u6297\u80bf\u7624\u548c\u4fc3\u80bf\u7624\u5bbf\u4e3b\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Dectin-1 <\/strong><\/p>\n

Dectin-1\u4e3b\u8981\u8bc6\u522b\u03b2-\u8461\u805a\u7cd6\u7ed3\u6784\uff0c\u6709\u52a9\u4e8e\u62b5\u5fa1\u7ec6\u83cc\u548c\u771f\u83cc\u611f\u67d3\u3002Dectin-1\u88ab\u8fd9\u6837\u7684\u78b3\u6c34\u5316\u5408\u7269\u6fc0\u6d3b\u540e\uff0c\u901a\u8fc7\u5176\u81ea\u8eab\u7684hemITAM\u57fa\u5e8f\u6fc0\u6d3bSyk\u4f9d\u8d56\u7684\u4fe1\u53f7\u8f6c\u5bfc\u3002<\/p>\n

\u5728\u63a7\u5236\u76ae\u4e0b\u80bf\u7624\u751f\u957f\u548c\u80ba\u8f6c\u79fb\u65b9\u9762\uff0cDectin-1\u901a\u8fc7\u589e\u5f3aNK\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u800c\u8bf1\u5bfc\u6297\u80bf\u7624\u53cd\u5e94\u3002\u8fd9\u79cd\u6297\u80bf\u7624\u673a\u5236\u662f\u901a\u8fc7Dectin-1\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u4e0a\u7684N-\u7cd6\u94fe\u7ed3\u6784\u6765\u89e6\u53d1\u7684\u3002<\/p>\n

\u867d\u7136Dectin-1\u662f\u4e00\u79cd\u03b2-\u8461\u805a\u7cd6\u53d7\u4f53\uff0c\u4f46\u764c\u7ec6\u80de\u4e0a\u7684\u5404\u79cd\u7cd6\u94fe\u7ed3\u6784\u4e5f\u53ef\u80fd\u4e0eDectin-1\u7ed3\u5408\u3002\u764c\u7ec6\u80de\u6fc0\u6d3b\u9ad3\u7cfb\u7ec6\u80de\u4e2d\u7684Dectin-1\u4fe1\u53f7\uff0c\u4ee5\u7ec6\u80de\u5bf9\u7ec6\u80de\u63a5\u89e6\u7684\u65b9\u5f0f\u4fc3\u8fdbNK\u7ec6\u80de\u7684\u6297\u80bf\u7624\u6740\u4f24\u4f5c\u7528\u3002<\/p>\n

\u652f\u6301\u8fd9\u4e00\u89c2\u70b9\u7684\u662f\uff0c\u5728\u764c\u7ec6\u80de\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0cDectin-1\u4e0a\u8c03\u4e86INAM\u7684\u8868\u8fbe\uff0cINAM\u662f\u4e00\u79cd\u9a71\u52a8NK\u7ec6\u80de\u6fc0\u6d3b\u7684\u819c\u86cb\u767d\u3002NK\u7ec6\u80de\u4ecb\u5bfc\u7684\u80bf\u7624\u6740\u4f24\u4e5f\u53ef\u4ee5\u8bf1\u5bfc\u5bf9\u809d\u8f6c\u79fb\u764c\u7ec6\u80de\u7684\u6740\u4f24\u3002Dectin-1\u901a\u8fc7NK\u7ec6\u80de\u589e\u5f3a\u5bf9SL4\u7ed3\u80a0\u764c\u7ec6\u80de\u7684\u6740\u4f24\u6d3b\u6027\u4ee5\u6291\u5236\u809d\u8f6c\u79fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f9d\u8d56Dectin-1\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u53ef\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u3002\u5728\u4eba\u4f53\u7814\u7a76\u4e2d\uff0c\u670d\u7528\u4ece\u9999\u83c7\u4e2d\u5206\u79bb\u51fa\u6765\u7684\u7eaf\u5316\u03b2-\u8461\u805a\u7cd6–\u6241\u8c46\u5357\uff08lentinan\uff09\u53ef\u6291\u5236\u80c3\u764c\u7684\u53d1\u5c55\u3002<\/p>\n

\u6b64\u5916\uff0c\u5f53\u4e0e\u987a\u94c2\u3001\u963f\u9709\u7d20\u548c\u73af\u78f7\u9170\u80fa\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u897f\u4f50\u5583\uff08\u4ece\u9999\u83c7\u4e2d\u63d0\u53d6\u7684\u03b2-\u8461\u805a\u7cd6\uff09\u53ef\u6539\u5584\u5375\u5de2\u764c\u60a3\u8005\u7684\u9884\u540e\u3002<\/p>\n

\u03b2-\u8461\u805a\u7cd6\u5bf9\u80bf\u7624\u751f\u957f\u3001\u4e73\u817a\u764c\u548c\u809d\u8f6c\u79fb\u7684\u5c0f\u9f20\u4f53\u5185\u6a21\u578b\u4e5f\u6709\u6cbb\u7597\u4f5c\u7528\u3002\u03b2-\u8461\u805a\u7cd6\u8bf1\u5bfc\u6297\u80bf\u7624\u6548\u5e94\u7684\u673a\u5236\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002<\/p>\n

Dectin-1\u6fc0\u52a8\u5242Curdlan\u53ef\u6fc0\u6d3bDC\u4ee5\u8bf1\u5bfc\u5f3a\u5927\u7684CD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\uff0c\u5e76\u663e\u8457\u51cf\u5c11B16\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u80ba\u8f6c\u79fb\u3002\u6b64\u5916\uff0c\u4ece\u8611\u83c7\u4e2d\u63d0\u53d6\u7684\u542b\u6709\u03b2\u8461\u805a\u7cd6\u7684\u63d0\u53d6\u7269\u53ef\u4ee5\u4fc3\u8fdbNK\u7ec6\u80de\u7684\u6269\u589e\uff0c\u5e76\u4e0a\u8c03\u6297\u80bf\u7624\u7ec6\u80de\u56e0\u5b50\uff08\u5982IFN-\u03b3\u548cIL-12\uff09\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u964d\u4f4e\u7ed3\u80a0\u764c\u7ec6\u80deCT26\u63a5\u79cd\u5c0f\u9f20\u7684\u80bf\u7624\u8d1f\u8377\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86\u6fc0\u53d1\u6297\u80bf\u7624\u514d\u75ab\u5916\uff0c\u03b2-\u8461\u805a\u7cd6\u8fd8\u53ef\u4ee5\u6291\u5236\u4fc3\u80bf\u7624\u5bbf\u4e3b\u53cd\u5e94\u3002\u6765\u81ea\u917f\u9152\u9175\u6bcd\u7684\u5b8c\u6574\u03b2-\u8461\u805a\u7cd6\u9897\u7c92(WGP)\u4e0b\u8c03\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff08MDSCs\uff09\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027\uff0c\u5e76\u6291\u5236MDSCs\u548cTregs\u5728TME\u4e2d\u7684\u6269\u5f20\u3002WGP\u8fd8\u4ee5\u4f9d\u8d56Dectin-1\u548cCARD9\u7684\u65b9\u5f0f\u5c06\u514d\u75ab\u6291\u5236\u7684M2\u6837\u5de8\u566c\u7ec6\u80de\u8f6c\u5316\u4e3aM1\u6837\u7ec6\u80de\u3002<\/p>\n

CARD9\u662f\u4e00\u79cd\u4fe1\u53f7\u5206\u5b50\uff0c\u7531ITAM\u76f8\u5173CLR\u6fc0\u6d3b\uff0c\u5982Dectin-1\uff0c\u53ef\u8bf1\u5bfc\u6297\u80bf\u7624\u53cd\u5e94\u3002\u7528\u8611\u83c7\u63d0\u53d6\u7684\u03b2-\u8461\u805a\u7cd6\u6cbb\u7597\u7684\u5c0f\u9f20\u4e5f\u8868\u73b0\u51faTME\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684\u4e27\u5931\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Dectin-2<\/strong><\/p>\n

Dectin-2\u4e0e\u5bcc\u542b\u7518\u9732\u7cd6\u7684\u78b3\u6c34\u5316\u5408\u7269\u7ed3\u5408\uff0c\u8f6c\u5bfcSyk\u4f9d\u8d56\u7684\u4fe1\u53f7\u3002\u4e0eDectin-1\u4e0d\u540c\uff0cDectin-2\u4e0d\u5177\u6709ITAM\u57fa\u5e8f\u3002\u76f8\u53cd\uff0c\u5b83\u4e0e\u81ea\u8eab\u5177\u6709ITAM\u57fa\u5e8f\u7684FcR\u03b3\u94fe\u7ed3\u5408\uff0c\u6765\u6fc0\u6d3b\u4e0b\u6e38\u901a\u8def\u3002<\/p>\n

\u4e0e\u5176\u4ed6CLR\u76f8\u6bd4\uff0cDectin-2\u5728\u80bf\u7624\u514d\u75ab\u4e2d\u7684\u4f5c\u7528\u662f\u76f8\u5bf9\u72ec\u7279\u7684\u3002Dectin-1\u6291\u5236\u76ae\u4e0b\u80bf\u7624\u751f\u957f\u548c\u80ba\u8f6c\u79fb\uff0c\u800cDectin-2\u5e76\u4e0d\u53c2\u4e0e\u8fd9\u4e9b\u53cd\u5e94\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cDectin-2\u6709\u52a9\u4e8e\u6291\u5236\u809d\u8f6c\u79fb\u3002\u5176\u6f5c\u5728\u7684\u673a\u5236\u8f83\u4e3a\u72ec\u7279\uff0c\u56e0\u4e3aDectin-2\u5728\u4f53\u5916\u4fc3\u8fdbKupffer\u7ec6\u80de(\u809d\u810f\u5de8\u566c\u7ec6\u80de)\u5bf9\u764c\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\uff0c\u4f46\u662f\u8fd9\u79cd\u4f9d\u8d56Dectin-2\u7684\u764c\u7ec6\u80de\u5728\u6444\u53d6\u9aa8\u9ad3\u6765\u6e90\u7684\u5de8\u566c\u7ec6\u80de\u548c\u80ba\u6ce1\u5de8\u566c\u7ec6\u80de\u4e2d\u6ca1\u6709\u89c2\u5bdf\u5230\u3002\u4e0e\u6b64\u4e00\u81f4\uff0cDectin-2\u7f3a\u9677\u5c0f\u9f20\u7684\u809d\u810f\u80bf\u7624\u8f6c\u79fb\u663e\u8457\u589e\u5f3a\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5f53 Dectin-2 \u88ab\u771f\u83cc\u6fc0\u6d3b\u65f6\u4f1a\u8bf1\u5bfc IL-6 \u548c CXCL1 \u7684\u8868\u8fbe\uff0c\u800c\u5f53 Dectin-2 \u7f3a\u5931\u7684 Kupffer \u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u65f6\uff0cIL-6 \u548c CXCL1 \u7684\u8868\u8fbe\u4e0d\u53d7\u5f71\u54cd\u3002\u8fd9\u4e00\u89c2\u5bdf\u7ed3\u679c\u8868\u660e\uff0cKupffer \u7ec6\u80de\u4e2d\u7684\u6297\u80bf\u7624 Dectin-2 \u4fe1\u53f7\u901a\u8def\u4e0d\u540c\u4e8e\u4f20\u7edf\u7684\u6297\u5fae\u751f\u7269\u53cd\u5e94\u901a\u8def\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

Mincle<\/strong><\/p>\n

\u5de8\u566c\u7ec6\u80de\u8bf1\u5bfc\u7684C\u578b\u51dd\u96c6\u7d20(Mincle)\u53ef\u4e0e\u7518\u9732\u7cd6\u4ee5\u53ca\u6d77\u85fb\u7cd6\u4e8c\u9709\u83cc\u9178\u916f(TDM\uff0c\u4e00\u79cd\u5206\u679d\u6746\u83cc\u7cd6\u8102)\u7ed3\u5408\u3002Mincle\u8fd8\u8bc6\u522b\u5185\u6e90\u6027\u6838\u7cd6\u6838\u86cb\u767d\u526a\u63a5\u4f53\u76f8\u5173\u86cb\u767d130(SAP-130)\uff0c\u8fd9\u79cd\u86cb\u767d\u662f\u4ece\u6fd2\u6b7b\u7ec6\u80de\u4e2d\u91ca\u653e\u51fa\u6765\u7684\u3002Mincle \u5728\u5176\u914d\u4f53\u7684\u523a\u6fc0\u4e0b\uff0c\u901a\u8fc7\u5177\u6709 ITAM \u7684 FcR\u03b3 \u94fe\u8bf1\u5bfc Syk \u4f9d\u8d56\u6027\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n

\u5728P48 Cre\uff1bKras G12D\u5c0f\u9f20\u80f0\u817a\u764c\u7684\u53d1\u5c55\u4e2d\uff0cMincle\u5efa\u7acb\u4e86\u4e00\u79cd\u514d\u75ab\u6291\u5236TME\u5e76\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u53d1\u5c55\u3002Mincle\u4fe1\u53f7\u589e\u5f3aT\u7ec6\u80de\u4ea7\u751fIL-10\u4ee5\u53ca\u80bf\u7624\u4e2dMDSCs\u548cM2\u6837\u5de8\u566c\u7ec6\u80de\u7684\u6e17\u900f\u3002\u8fd9\u4e00\u81f4\u764c\u8fc7\u7a0b\u4e0e\u80f0\u817a\u574f\u6b7b\u548cSAP-130\u8868\u8fbe\u7684\u8bf1\u5bfc\u6709\u5173\u3002\u7531\u4e8eSAP-130\u5728\u80f0\u817a\u5185\u6ce8\u5c04\u4f1a\u52a0\u5267\u80bf\u7624\u7684\u751f\u957f\uff0cMincle\u4e0e\u6b7b\u4ea1\u7ec6\u80de\u91ca\u653e\u7684SAP-130\u8fde\u63a5\uff0c\u5728\u514d\u75ab\u6291\u5236\u7684\u60c5\u51b5\u4e0b\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u5f62\u6210\u8fc7\u7a0b\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u5c3d\u7ba1Mincle\u5728\u80f0\u817a\u80bf\u7624\u8fdb\u5c55\u4e2d\u76f8\u5bf9\u91cd\u8981\uff0c\u4f46\u5b83\u5e76\u4e0d\u80fd\u63a7\u5236SL4\u7ed3\u80a0\u764c\u7ec6\u80de\u7684\u809d\u8f6c\u79fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

CLEC-2<\/strong><\/p>\n

CLEC-2\u662f\u4e00\u79cd\u86c7\u6bd2\u6bd2\u7d20\u2014\u2014\u86c7\u6bd2\u86cb\u767d\u7684\u53d7\u4f53\uff0c\u7528\u86c7\u6bd2\u86cb\u767d\u523a\u6fc0\u53ef\u8bf1\u5bfc\u4e0e ITAM \u4f9d\u8d56\u6027\u7c7b\u4f3c\u7684\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n

CLEC-2\u8fd8\u8bc6\u522bpodoplanin\u86cb\u767d\uff0c\u8fd9\u662f\u4e00\u79cd\u5728\u4e00\u4e9b\u764c\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u7c98\u86cb\u767d\u3002\u5c3d\u7ba1CLEC-2\u5728\u4f53\u5185\u7684\u7814\u7a76\u53d7\u5230CLEC-2\u7f3a\u9677\u5c0f\u9f20\u80da\u80ce\u81f4\u6b7b\u56f0\u96be\u7684\u6311\u6218\uff0c\u4f46CLEC-2\u4e0epodoplanin\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\u4ecd\u88ab\u8ba4\u4e3a\u662f\u4fc3\u8fdb\u80bf\u7624\u8f6c\u79fb\u7684\u5173\u952e\u4e8b\u4ef6\u3002<\/p>\n

\u8868\u8fbeCLEC-2\u7684\u8840\u5c0f\u677f\u88ab\u764c\u7ec6\u80de\u4e0a\u7684\u5e73\u8db3\u86cb\u767d\u6fc0\u6d3b\uff0c\u89e6\u53d1\u5b83\u4eec\u7684\u805a\u96c6\u3002\u8840\u5c0f\u677f\u805a\u96c6\u4e3b\u8981\u901a\u8fc7\u906e\u853d\u514d\u75ab\u7ec6\u80de\u7684\u68c0\u6d4b\u6765\u652f\u6301\u764c\u7ec6\u80de\u4ece\u514d\u75ab\u7cfb\u7edf\u4e2d\u9003\u8131\uff0c\u540c\u65f6\u8fd8\u901a\u8fc7\u4fc3\u8fdb\u4e0e\u8840\u7ba1\u5185\u76ae\u58c1\u7684\u9ecf\u9644\u6765\u4fc3\u8fdb\u8f6c\u79fb\u3002<\/p>\n

\u6b64\u5916\uff0cCLEC-2\u7684\u6fc0\u6d3b\u8bf1\u5bfc\u751f\u957f\u56e0\u5b50\u3001\u8d8b\u5316\u56e0\u5b50\u3001\u57fa\u8d28\u86cb\u767d\u548c\u8840\u7ba1\u751f\u6210\u56e0\u5b50\u7684\u5206\u6ccc\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u8f6c\u79fb\u3002<\/p>\n

CLEC-2\u8fd8\u6fc0\u6d3b\u764c\u7ec6\u80de\u4e2d\u7684podoplanin\u4fe1\u53f7\uff0c\u5bfc\u81f4E-cadherin\u7684\u4e0b\u8c03\u5e76\u4fc3\u8fdb\u764c\u8f6c\u79fb\u3002podoplanin\u86cb\u767d\u4e0e\u8840\u5c0f\u677f\u7684\u76f8\u4e92\u4f5c\u7528\u52a0\u901f\u4e86\u8868\u8fbepodoplanin\u86cb\u767d\u7684PC-10\u80ba\u764c\u7ec6\u80de\u7684\u76ae\u4e0b\u80bf\u7624\u751f\u957f\u3002<\/p>\n

\u56e0\u6b64\uff0c\u6211\u4eec\u80af\u5b9aCLEC-2\u5728\u80bf\u7624\u53d1\u5c55\u7684\u591a\u4e2a\u6b65\u9aa4\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

DC-SIGN<\/strong><\/p>\n

DC\u7279\u5f02\u6027ICAM-3\u652b\u53d6\u975e\u6574\u5408\u7d20(DC-SIGN)\u5bf9\u7518\u9732\u7cd6\u3001\u5ca9\u85fb\u7cd6\u3001N-\u4e59\u9170\u6c28\u57fa\u8461\u8404\u7cd6\u548cLewis\u6297\u539f\u663e\u793a\u51fa\u9ad8\u4eb2\u548c\u529b\u3002DC-SIGN\u6fc0\u6d3b\u901a\u8fc7\u6dcb\u5df4\u7ec6\u80de\u7279\u5f02\u6027\u86cb\u767d1(LSP1)\u9a71\u52a8ITAM\/ITIM\u975e\u4f9d\u8d56\u6027\u4fe1\u53f7\u4f20\u9012\uff0c\u4fc3\u8fdb\u6297\u539f\u5411CD8+<\/sup>T\u7ec6\u80de\u7684\u4ea4\u53c9\u9012\u5448\u3002\u4e0e\u6b64\u4e00\u81f4\u7684\u662f\uff0cLewis X\u5be1\u7cd6-\u4e59\u9170\u809d\u7d20\u9176\u590d\u5408\u4f53\u5904\u7406\u7684DC\u53ef\u589e\u5f3aCD8+<\/sup>T\u7ec6\u80de\u5e94\u7b54\uff0c\u5e76\u5177\u6709\u6291\u5236\u4f53\u5185G422\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\u751f\u957f\u7684\u80fd\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u65b9\u9762\uff0cDC-SIGN\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u8d77\u5230\u4fc3\u80bf\u7624\u4f5c\u7528\u3002DC-SIGN\u8bc6\u522b\u4e3b\u8981\u7531\u7ed3\u80a0\u764c\u7ec6\u80de\u8868\u8fbe\u7684\u764c\u80da\u6297\u539f(CEA)\u548cMac-2\u7ed3\u5408\u86cb\u767d(Mac-2BP)\u4e0a\u7684Lewis\u78b3\u6c34\u5316\u5408\u7269\u3002<\/p>\n

\u7531\u4e8e\u5de8\u566c\u7ec6\u80de\u4e0a\u7684DC-SIGN\u8fde\u63a5\u5230\u764c\u7ec6\u80de\u8bf1\u5bfc\u4ea7\u751fIL-10\uff0cDC-SIGN\u53ef\u80fd\u6709\u52a9\u4e8e\u5efa\u7acb\u514d\u75ab\u6291\u5236\u7684TME\u3002\u4e00\u4efd\u62a5\u544a\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8fd9\u4e00\u89c2\u70b9\uff0c\u8be5\u62a5\u544a\u663e\u793a\uff0c\u4e0eWT\u5c0f\u9f20\u76f8\u6bd4\uff0cDC-SIGN\u7f3a\u9677\u5c0f\u9f20\u7684LLC\u7ec6\u80de\u76ae\u4e0b\u80bf\u7624\u751f\u957f\u8f83\u6162\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

MGL<\/strong><\/p>\n

\u5de8\u566c\u7ec6\u80de\u534a\u4e73\u7cd6C\u578b\u51dd\u96c6\u7d20(MGL)\u5177\u6709\u534a\u4e73\u7cd6\u548cN-\u4e59\u9170\u534a\u4e73\u7cd6\u80fa\u7684\u914d\u4f53\u8bc6\u522b\u7279\u6027\u3002MGL\u4e0e\u5fae\u751f\u7269\u4e0a\u7684\u8fd9\u79cd\u78b3\u6c34\u5316\u5408\u7269\u90e8\u5206\u7ed3\u5408\u53ef\u4fc3\u8fdb\u5176\u6444\u53d6\uff0c\u5e76\u5bfc\u81f4\u6297\u539f\u5448\u9012\u3002<\/p>\n

\u6b64\u5916\uff0cMGL\u8bc6\u522b\u591a\u79cd\u764c\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u7c98\u86cb\u767d1(MUC1)\u4e0a\u7684\u78b3\u6c34\u5316\u5408\u7269\u6297\u539fTn\u548csialyl Tn\uff08\u553e\u6db2\u9178-Tn\uff09\u3002\u867d\u7136\u553e\u6db2\u9178\u5316Tn-\u76f8\u5173MUC1\u89e6\u53d1\u7684MGL\u6fc0\u6d3b\u4fc3\u8fdb\u4e86DC\u7684\u6210\u719f\u548c\u8fc1\u79fb\uff0c\u4f46\u6297MGL\u963b\u65ad\u6297\u4f53\u6291\u5236\u4e86\u8db3\u57ab\u63a5\u79cd\u7684\u764c\u7ec6\u80de\u5411\u6dcb\u5df4\u7ed3\u7684\u6269\u6563\u3002\u56e0\u6b64\uff0cMGL\u53ef\u80fd\u5728\u6dcb\u5df4\u8f6c\u79fb\u4e2d\u5177\u6709\u4fc3\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

MR <\/strong><\/p>\n

\u7518\u9732\u7cd6\u53d7\u4f53(MR)\u8bc6\u522b\u7518\u9732\u7cd6\u5e76\u4fc3\u8fdb\u5176\u5185\u541e\u3002\u5df2\u77e5\u5375\u6e05\u86cb\u767d(OVA)\u4e0e\u4eba\u5de5\u5408\u6210\u7684MR\u914d\u4f53\u30013-\u78fa\u9178-Lewis A\u548c\u4e09-N-\u4e59\u9170\u6c28\u57fa\u8461\u8404\u7cd6\u5076\u8054\uff0c\u53ef\u542f\u52a8DC\u8bf1\u5bfc\u6297\u539f\u7279\u5f02\u6027CD8+<\/sup>T\u7ec6\u80de\u589e\u6b96\u548cCD4+<\/sup>T\u7ec6\u80deTh1\u6781\u5316\u3002\u56e0\u6b64\uff0cMR\u4e0e\u5176\u914d\u4f53\u7684\u8fde\u63a5\u53ef\u80fd\u4f1a\u8bf1\u5bfc\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0cOVA\u4e0e\u6297MR\u6297\u4f53\u8054\u5408\u6cbb\u7597\u53ef\u5728\u4f53\u5185\u6fc0\u53d1CD8+<\/sup>T\u7ec6\u80de\u53cd\u5e94\uff0c\u4e0e CpG \u5904\u7406\u4e00\u8d77\uff0c\u53ef\u663e\u8457\u964d\u4f4e\u8868\u8fbe OVA \u7684 B16 \u7ec6\u80de\u5728 MR \u8f6c\u57fa\u56e0\u5c0f\u9f20\u76ae\u4e0b\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7136\u800c\uff0cMR\u4e5f\u5177\u6709\u4fc3\u80bf\u7624\u6d3b\u6027\u3002MR\u53c2\u4e0e\u80bf\u7624\u7279\u5f02\u6027\u7c98\u86cb\u767dCA-125\u548cTAG-72\u7684\u8bc6\u522b\u3002\u7528\u8fd9\u4e9b\u5206\u5b50\u523a\u6fc0\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de(TAM)\u4e0a\u7684MR\u53ef\u8bf1\u5bfcIL-10\u7684\u4ea7\u751f\u5e76\u6291\u5236IL-12\u7684\u8868\u8fbe\u3002<\/p>\n

\u6b64\u5916\uff0c\u80bf\u7624\u6fc0\u6d3b\u7684\u809d\u7aa6\u5185\u76ae\u7ec6\u80de(LSECs)\u4e0a\u8868\u8fbe\u7684MR\u6291\u5236\u4e86\u809d\u7aa6\u6dcb\u5df4\u7ec6\u80de(LSLs)\u7684\u6297\u80bf\u7624\u7ec6\u80de\u6bd2\u4f5c\u7528\u3002MR\u8fdb\u4e00\u6b65\u5206\u522b\u51cf\u5c11\u548c\u589e\u52a0\u4e86\u8377\u7624\u5c0f\u9f20\u7684LSL\u4ea7\u751f\u7684\u5e72\u6270\u7d20-\u03b3\u548cIL-10\u3002\u8fd9\u4e9b\u62a5\u544a\u4ee4\u4eba\u8054\u60f3\u5230 MR \u4f1a\u4fc3\u8fdb\u764c\u75c7\u7684\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

MCL <\/strong><\/p>\n

MCL \u662f\u4e00\u79cd\u4e0e FcR\u03b3 \u76f8\u5173\u7684 TDM \u53d7\u4f53\uff0c\u4e5f\u662f Dectin-2 \u7684\u5f02\u6e90\u4e8c\u805a\u4f53\u5bf9\u5e94\u7269\u3002\u4e0e\u6b64\u4e00\u81f4\uff0c\u4e0eDectin-2\u4e00\u6837\uff0cMCL\u589e\u5f3aKupffer\u7ec6\u80de\u7684\u541e\u566c\u6d3b\u6027\uff0c\u5e76\u6291\u5236SL4\u7ed3\u80a0\u764c\u7ec6\u80de\u7684\u809d\u8f6c\u79fb\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c3d\u7ba1MCL\u8bf1\u5bfc\u9aa8\u9ad3\u6765\u6e90\u7684\u5de8\u566c\u7ec6\u80de\u8868\u8fbeMincle\uff0c\u4f46\u5982\u4e0a\u6240\u8ff0\uff0cMincle\u5e76\u4e0d\u53c2\u4e0e\u63a7\u5236\u809d\u8f6c\u79fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5176\u4ed6CLR<\/strong><\/p>\n

\u5176\u4ed6CLR\u5728\u764c\u75c7\u4e2d\u7684\u4f5c\u7528\u4e5f\u5df2\u7ecf\u88ab\u7814\u7a76\u8fc7\uff0c\u4f46\u8fd8\u4e0d\u662f\u5f88\u5e7f\u6cdb\u3002\u4e00\u4e9b\u7814\u7a76\u8868\u660e\uff0cTME\u4e2d\u91ca\u653e\u7684DAMPs\u53ef\u4ee5\u8c03\u8282\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u6b64\u5916\uff0c\u4e00\u4e9bDAMP\u8fd8\u53ef\u4ee5\u4f5c\u4e3aCLRs\u7684\u914d\u4f53\u3002DC NK\u51dd\u96c6\u7d20\u53d7\u4f53-1(DNGR-1)\u8bc6\u522bF-\u808c\u52a8\u86cb\u767d\u548c\u8840\u5f71\u86cb\u767d\u03b2\u4e0e\u03b1-\u808c\u52a8\u86cb\u767d\u7684\u808c\u52a8\u86cb\u767d\u590d\u5408\u4f53\uff0c\u8fd9\u4e24\u79cd\u7269\u8d28\u90fd\u4f1a\u88ab\u53d7\u635f\u7ec6\u80de\u66b4\u9732\u51fa\u6765\u3002<\/p>\n

F-\u808c\u52a8\u86cb\u767d\u53ef\u4ee5\u5728\u8868\u8fbeDNGR-1\u7684\u7ec6\u80de\u4e2d\u9a71\u52a8Syk\u4f9d\u8d56\u7684\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u53c2\u4e0e\u4e86DNGR-1\u5728\u5bbf\u4e3b\u4f53\u5185\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n

\u6b64\u5916\uff0cCLEC12A \u8fd8\u80fd\u4e0e\u6b7b\u4ea1\u7ec6\u80de\u4e2d\u7684\u5c3f\u9178\u7ed3\u6676\u7ed3\u5408\uff0c\u6291\u5236\u4f53\u5185\u4e2d\u6027\u7c92\u7ec6\u80de\u5728\u53d7\u5230\u574f\u6b7b\u7ec6\u80de\u6216\u8f90\u7167\u540e\u5f15\u53d1\u7684\u708e\u75c7\u3002<\/p>\n

\u5c3f\u9178\u8fd8\u6709\u52a9\u4e8eDC\u6210\u719f\u3001CD8+<\/sup> T\u7ec6\u80de\u542f\u52a8\u548cTh17\u5206\u5316\u3002\u56e0\u6b64\uff0cCLEC12A \u53ef\u80fd\u4f1a\u5728\u6b7b\u7ec6\u80de\u4e30\u5bcc\u7684\u5fae\u73af\u5883\u4e2d\u8c03\u8282\u80bf\u7624\u7684\u53d1\u5c55\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

CLRs<\/strong>\u5728\u80bf\u7624\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\u53ef\u80fd\u4e0d\u53ea\u662f\u611f\u77e5DAMPs\u3002<\/p>\n

\u7518\u9732\u7cd6\u7ed3\u5408\u51dd\u96c6\u7d20(MBL)\u8bc6\u522bSW1116\u4eba\u7ed3\u80a0\u764c\u7ec6\u80de\u8868\u9762\u7684Lewis\u6297\u539f\u3002\u6b64\u5916\uff0c\u8840\u6db2\u6811\u7a81\u72b6\u7ec6\u80de\u6297\u539f 2\uff08BDCA-2\uff09\u53ea\u5728 pDC \u4e0a\u8868\u8fbe\uff0c\u5e76\u88ab\u5e26\u6709\u672b\u7aef\u534a\u4e73\u7cd6\u7684\u4eba\u9020\u5be1\u7cd6\u6fc0\u6d3b\uff0c\u6291\u5236 I \u578b IFN \u7684\u4ea7\u751f\uff0c\u5b83\u80fd\u4e0e\u591a\u79cd\u4eba\u7c7b\u764c\u7ec6\u80de\uff08\u5982\u5375\u5de2\u764c\u548c\u7ed3\u80a0\u764c\u7ec6\u80de\uff09\u7ed3\u5408\u3002<\/p>\n

\u9664\u4e0a\u8ff0\u53d7\u4f53\u5916\uff0c\u57fa\u4e8e ITAM \u7684 CLR\uff08\u5982 SIGN \u76f8\u5173\u57fa\u56e0 3\uff08SIGNR3\uff09\u548c\u9ad3\u6837 DAP12 \u76f8\u5173\u51dd\u96c6\u7d20\uff08MDL-1\uff09\uff09\u4e5f\u53ef\u80fd\u53c2\u4e0e\u80bf\u7624\u751f\u957f\uff0c\u56e0\u4e3a CARD9 \u4f1a\u4fc3\u8fdb APC \u5c0f\u9f20\u96c4\u6027\u7684\u7ed3\u80a0\u80bf\u7624\u53d1\u751f\u3002<\/p>\n

\u8fdb\u4e00\u6b65\u5206\u6790\u8fd9\u4e9b\u53d7\u4f53\u5728\u764c\u75c7\u514d\u75ab\u53cd\u5e94\u4e2d\u7684\u529f\u80fd\uff0c\u6709\u52a9\u4e8e\u66f4\u597d\u5730\u7406\u89e3 CLR \u4ecb\u5bfc\u7684\u80bf\u7624\u53d1\u751f\u8c03\u63a7\u3002<\/p>\n

\u4e0e\u6b64\u76f8\u5173\uff0cITIM \u76f8\u5173\u7684 CLR \u5982\u4f55\u53c2\u4e0e\u80bf\u7624\u751f\u957f\u548c\u8f6c\u79fb\u7684\u8c03\u63a7\uff0c\u8fd9\u4e2a\u8fc4\u4eca\u5c1a\u4e0d\u6e05\u695a\u7684\u95ee\u9898\u4e5f\u662f\u4e00\u4e2a\u6709\u5f85\u6f84\u6e05\u7684\u6709\u8da3\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

25.1.4 Nod\u6837\u53d7\u4f53\uff08NLRs\uff09\u5728\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528<\/p>\n<\/section>\n

\n
\n
\n

\u708e\u75c7\u5c0f\u4f53\u662f\u4e00\u79cd\u591a\u86cb\u767d\u590d\u5408\u4f53\uff0c\u7531PRR\u3001\u542b\u6709 CARD \u7684\u8fde\u63a5\u86cb\u767d\u51cb\u4ea1\u76f8\u5173\u6591\u70b9\u6837\u86cb\u767d (ASC)\u548ccaspase-1\u7ec4\u6210\u3002<\/p>\n

\u8fd9\u4e9bPRR\u5305\u62ecNLR\u6210\u5458\u548cAIM2\u6837\u53d7\u4f53\u5bb6\u65cf\u6210\u5458\uff0c\u5e76\u5206\u522b\u8bc6\u522b\u611f\u67d3\u6216\u7ec6\u80de\u635f\u4f24\u65f6\u7684\u5404\u79cdPAMP\u548cDAMP\uff0c\u4ee5\u62db\u52dfASC\u5e76\u89e6\u53d1caspase-1\u6fc0\u6d3b\u3002\u6fc0\u6d3b\u7684caspase-1\u968f\u540e\u5c06\u524d-IL-1\u03b2\u548c\u524d-IL-18\u88c2\u89e3\u6210\u5b83\u4eec\u7684\u6210\u719f\u5f62\u5f0f\u3002<\/p>\n

\u708e\u75c7\u5c0f\u4f53\u53c2\u4e0e\u5bbf\u4e3b\u5bf9\u75c5\u539f\u4f53\u7684\u9632\u5fa1\u4ee5\u53ca\u81ea\u8eab\u708e\u75c7\u3001\u795e\u7ecf\u9000\u884c\u6027\u548c\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u3002\u6709\u8bc1\u636e\u8868\u660e\uff0c\u708e\u75c7\u5c0f\u4f53\u53c2\u4e0e\u4e86\u764c\u75c7\u7684\u53d1\u5c55\uff0c\u8fd9\u4e00\u70b9\u4e5f\u4e0d\u8db3\u4e3a\u5947\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NLRP3<\/strong><\/p>\n

NLRP3\u8bc6\u522b\u591a\u79cd\u914d\u4f53\uff0c\u5305\u62ec\u7ec6\u83ccDNA\uff1aRNA\u6742\u5408\u4f53\u3001\u8702\u6bd2\u3001\u4e09\u78f7\u9178\u817a\u82f7\u3001\u5c3f\u9178\u6676\u4f53\u3001\u6c22\u6c27\u5316\u94dd\u548c\u77f3\u68c9\u3002NLRP3\u708e\u75c7\u5c0f\u4f53\u9700\u8981\u4e24\u4e2a\u4fe1\u53f7\u624d\u80fd\u5b8c\u5168\u6fc0\u6d3b\u3002\u7b2c\u4e00\u4e2a\u4fe1\u53f7\u662f\u7531\u51e0\u4e2a\u53d7\u4f53\u4ecb\u5bfc\u7684\uff0c\u5176\u4e2dTLRs\u662f\u4f17\u6240\u5468\u77e5\u7684\u6fc0\u6d3bNF-\u03baB\u4ecb\u5bfc\u7684NLRP3\u4e0a\u8c03\u7684\u53d7\u4f53\u3002\u7b2c\u4e8c\u4e2a\u4fe1\u53f7\u7531\u5176\u914d\u4f53\u4ecb\u5bfc\uff0c\u968f\u540e\u4fc3\u8fdb\u708e\u75c7\u5c0f\u4f53\u7ec4\u88c5\u3001caspase-1\u6fc0\u6d3b\u4ee5\u53caIL-1\u03b2\u548cIL-18\u7684\u91ca\u653e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NLRP3 \u5728\u80bf\u7624\u53d1\u751f\u4e2d\u7684\u4f5c\u7528\u4f3c\u4e4e\u53d6\u51b3\u4e8e\u5177\u4f53\u60c5\u51b5\u548c\u5177\u4f53\u5668\u5b98\u3002\u8bb8\u591a\u7814\u7a76\u5173\u6ce8 NLRP3 \u5728\u7ed3\u80a0\u764c\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u4e9b\u7814\u7a76\u901a\u5e38\u63cf\u8ff0\u4e86 NLRP3 \u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n

\u4f8b\u5982\uff0c\u5728 AOM\/DSS \u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\uff0cNLRP3 \u7f3a\u5931\u7684\u5c0f\u9f20\u663e\u793a\u80bf\u7624\u8d1f\u8377\u589e\u52a0\u3002\u80bf\u7624\u90e8\u4f4d IL-1\u03b2 \u548c IL-18 \u6c34\u5e73\u7684\u964d\u4f4e\u89e3\u91ca\u4e86\u8fd9\u79cd\u6548\u5e94\u3002\u7814\u7a76\u8fd8\u8868\u660e\uff0c\u9020\u8840\u7ec6\u80de\u4e2d\u7684 NLRP3 \u662f\u9020\u6210\u8fd9\u79cd\u6548\u5e94\u7684\u539f\u56e0\u3002<\/p>\n

\u53e6\u4e00\u9879\u7814\u7a76\u62a5\u544a\u79f0\uff0cNLRP3 \u7f3a\u4e4f\u5bfc\u81f4 IL-18 \u6c34\u5e73\u964d\u4f4e\uff0c\u4ece\u800c\u5f71\u54cd IFN-\u03b3 \u7684\u4ea7\u751f\uff0c\u4f7f\u6297\u80bf\u7624\u514d\u75ab\u529b\u4e0d\u8db3\u3002<\/p>\n

\u540c\u6837\uff0c\u5728\u7ed3\u80a0\u764c\u7ec6\u80de\u682a MC38 \u7684\u809d\u8f6c\u79fb\u6a21\u578b\u4e2d\uff0cNLRP3 \u7f3a\u4e4f\u7684\u5c0f\u9f20\u66f4\u5bb9\u6613\u60a3\u8f6c\u79fb\u6027\u80bf\u7624\u3002\u8fd9\u662f\u56e0\u4e3a IL-18 \u7684\u8bf1\u5bfc\u4e0d\u8db3\u5bfc\u81f4 NK \u7ec6\u80de\u7684\u6740\u7624\u6d3b\u6027\u53d7\u635f\u3002<\/p>\n

\u53e6\u4e00\u4efd\u62a5\u544a\u8fd8\u663e\u793a\uff0cNLRP3\u7f3a\u9677\u5c0f\u9f20\u5728DMBA\/TPA\u76ae\u80a4\u4e73\u5934\u72b6\u7624\u6a21\u578b\u4e2d\u6bd4WT\u5c0f\u9f20\u7f79\u60a3\u66f4\u4e25\u91cd\u7684\u80bf\u7624\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4e00\u4efd\u62a5\u544a\u663e\u793a\u4e86\u901a\u8fc7NLRP3\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u7684\u4f5c\u7528\u3002\u5728MCA\u8bf1\u5bfc\u7684\u7ea4\u7ef4\u8089\u7624\u6a21\u578b\u4e2d\uff0cNLRP3\u7f3a\u9677\u5c0f\u9f20\u663e\u793a\u51fa\u80bf\u7624\u8d1f\u8377\u7684\u51cf\u5c11\u3002<\/p>\n

\u5728E0771\u5c0f\u9f20\u4e73\u817a\u817a\u764c\u7ec6\u80de\u3001B16F10\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u548cRM-1\u5c0f\u9f20\u524d\u5217\u817a\u764c\u7ec6\u80de\u7684\u80ba\u8f6c\u79fb\u6a21\u578b\u4e2d\u4e5f\u53d1\u73b0\u4e86\u80bf\u7624\u53d1\u751f\u53d1\u5c55\u7684\u51cf\u5c11\u3002<\/p>\n

\u80bf\u7624\u8d1f\u8377\u7684\u51cf\u8f7b\u4e0eNK\u7ec6\u80de\u9891\u7387\u7684\u589e\u52a0\u6709\u5173\uff1b\u8868\u660eCD11b+ Gr-1int\u9ad3\u7cfb\u7ec6\u80de\u4e0a\u7684NLRP3\u53c2\u4e0eNK\u7ec6\u80de\u7684\u52df\u96c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NLRP3\u4f5c\u4e3a\u51b3\u5b9a\u6297\u764c\u5316\u7597\u7597\u6548\u7684\u5173\u952e\u5206\u5b50\u4e5f\u4e00\u76f4\u662f\u4eba\u4eec\u5173\u6ce8\u7684\u7126\u70b9\uff0c\u5c3d\u7ba1\u7ed3\u679c\u5b58\u5728\u4e89\u8bae\u3002<\/p>\n

\u4e00\u4efd\u62a5\u544a\u663e\u793a\uff0c\u5965\u6c99\u5229\u94c2\u7684\u6297\u764c\u5316\u7597\u5bf9\u5728NLRP3\u7f3a\u9677\u5c0f\u9f20\u4e2d\u5efa\u7acb\u7684EL4\u5c0f\u9f20\u6dcb\u5df4\u7624\u65e0\u6548\u3002\u673a\u5236\u4e0a\uff0c\u6fd2\u6b7b\u7684\u80bf\u7624\u7ec6\u80de\u91ca\u653eATP\uff0c\u901a\u8fc7\u6811\u7a81\u72b6\u7ec6\u80de\u4e0a\u7684\u560c\u5464\u80fd\u53d7\u4f53\u6fc0\u6d3bNLRP3\uff0c\u5e76\u6210\u529f\u5730\u6fc0\u6d3bCD8+<\/sup>T\u7ec6\u80de\u3002<\/p>\n

\u76f8\u53cd\uff0c\u53e6\u4e00\u4efd\u62a5\u544a\u663e\u793a\uff0c\u6fc0\u6d3bMDSC\u4e0a\u7684NLRP3\u4f1a\u5bfc\u81f4IL-1\u03b2\u7684\u91ca\u653e\uff0c\u4ece\u800c\u6291\u52365-\u6c1f\u5c3f\u5627\u5576(5-FU)\u5316\u7597\u5bf9EL4\u6dcb\u5df4\u7624\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u56e0\u6b64\uff0cNLRP3\u7f3a\u9677\u5c0f\u9f20\u5bf9\u6297\u764c\u5316\u7597\u7684\u53cd\u5e94\u589e\u5f3a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NLRC4<\/strong><\/p>\n

\u51e0\u79cd\u7ec6\u83cc\u7684III\u578b\u5206\u6ccc\u7cfb\u7edf\u7684\u97ad\u6bdb\u86cb\u767d\u548c\u5185\u6746\u86cb\u767d\u662fNLRC4\u7684\u914d\u4f53\u3002\u8fd9\u4e9b\u914d\u4f53\u4e0d\u76f4\u63a5\u4e0eNLRC4\u76f8\u4e92\u4f5c\u7528\u3002\u76f8\u53cd\uff0c\u5b83\u4eec\u4e0e\u51e0\u79cdNAIP\u86cb\u767d\u7ed3\u5408\uff0c\u4ece\u800c\u6fc0\u6d3bNLRC4\u708e\u75c7\u5c0f\u4f53\u5e76\u5bfc\u81f4caspase-1\u6fc0\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728AOM\/DSS\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\uff0cNLRC4\u7f3a\u9677\u7684\u5c0f\u9f20\u53d1\u751f\u66f4\u591a\u7684\u80bf\u7624\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u7ed3\u80a0\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u589e\u52a0\uff0c\u540c\u65f6\u51cb\u4ea1\u51cf\u5c11\uff0c\u800cNLRC4\u5728\u7ed3\u80a0\u764c\u53d1\u751f\u4e2d\u7684\u4f5c\u7528\u5c1a\u672a\u89c1\u62a5\u9053\u3002<\/p>\n

\u53e6\u4e00\u4efd\u62a5\u544a\u663e\u793a\uff0c\u5728 B16F10 \u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\uff0cNLRC4 \u57fa\u56e0\u7f3a\u9677\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u901f\u5ea6\u52a0\u5feb\u3002\u80bf\u7624\u751f\u957f\u7684\u52a0\u5267\u4e0e\u708e\u6027\u5c0f\u4f53\u65e0\u5173\uff0c\u5de8\u566c\u7ec6\u80de\u4e0a\u7684 NLRC4 \u662f\u8bf1\u5bfc\u6297\u80bf\u7624\u9002\u5e94\u6027\u514d\u75ab\u6240\u5fc5\u9700\u7684\u8981\u7d20\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

NLRP6\u548cNLRP12<\/strong><\/p>\n

NLRP6\u548cNLRP12\u7684\u914d\u4f53\u4ecd\u7136\u662f\u4e00\u4e2a\u8c1c\uff0c\u5b83\u4eec\u65e2\u53ef\u4ee5\u4f5c\u4e3a\u708e\u75c7\u7684\u6fc0\u6d3b\u5242\uff0c\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u708e\u75c7\u7684\u6291\u5236\u56e0\u5b50\u3002NLRP6\u53ef\u4ee5\u901a\u8fc7\u8bf1\u5bfcIL-18\u9884\u9632\u5b9e\u9a8c\u6027\u7ed3\u80a0\u708e\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0cNLRP6\u6291\u5236\u5355\u6838\u7ec6\u80de\u589e\u751f\u6027\u674e\u65af\u7279\u83cc\u3001\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u548c\u5927\u80a0\u6746\u83cc\u611f\u67d3\u7684\u5de8\u566c\u7ec6\u80de\u4e2d\u7684MAPK\u548cNF-\u03baB\u4fe1\u53f7\u8f6c\u5bfc\u3002<\/p>\n

NLRP12\u53ef\u5728\u9f20\u75ab\u8036\u5c14\u68ee\u6c0f\u83cc\u548c\u590f\u6c0f\u759f\u539f\u866b\u611f\u67d3\u4e2d\u6fc0\u6d3bcaspase-1\u3002\u7136\u800c\uff0c\u5b83\u4e5f\u53ef\u4ee5\u6291\u5236\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\u611f\u67d3\u4e2d\u7684NF-\u03baB\u9014\u5f84\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728AOM\/DSS\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\uff0cNLRP6\u57fa\u56e0\u7f3a\u9677\u7684\u5c0f\u9f20\u6613\u53d1\u751f\u80bf\u7624\uff08\u5bf9\u80bf\u7624\u53d1\u751f\u975e\u5e38\u654f\u611f\uff09\uff0c\u8fd9\u8868\u660eNLRP6\u5177\u6709\u6297\u80bf\u7624\u4f5c\u7528\u3002\u6709\u8da3\u7684\u662f\uff0c\u8fd9\u79cd\u6613\u611f\u6027\u662f\u901a\u8fc7\u4e0e\u5c0f\u9f20\u5171\u5c45\u4f20\u64ad\u7684\u3002\u8fd9\u4e9b\u7ed3\u679c\u5f52\u56e0\u4e8e\u5fae\u751f\u7269\u7fa4\u8bf1\u5bfc\u7684CCL5\uff0c\u901a\u8fc7\u6fc0\u6d3bIL-6\u4ecb\u5bfc\u7684\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u4e86\u4e0a\u76ae\u7ec6\u80de\u7684\u589e\u6b96\u3002<\/p>\n

NLRP12\u7f3a\u4e4f\u7684\u5c0f\u9f20\u4e5f\u4f1a\u56e0\u975e\u5178\u578bNF-\u03baB\u6d3b\u5316\u5347\u9ad8\u800c\u5bfc\u81f4\u66f4\u4e25\u91cd\u7684\u80bf\u7624\u53d1\u751f\u3002\u6709\u7814\u7a76\u8ba4\u4e3a\uff0cNLRP12\u901a\u8fc7\u8c03\u8282NF-\u03baB\u8bf1\u5bfc\u6fc0\u9176\uff08NIK\uff09\u548cTNF\u53d7\u4f53\u76f8\u5173\u56e0\u5b503\uff08TRAF3\uff09\u7684\u529f\u80fd\uff0c\u6291\u5236\u975e\u5178\u578bNF-\u03baB\u901a\u8def\u3002<\/p>\n

\u53e6\u4e00\u9879\u7814\u7a76\u4e5f\u62a5\u9053\u4e86 NLRP12 \u5728\u540c\u4e00\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u6291\u5236\u4f5c\u7528\u4ee5\u53ca\u5bf9\u5178\u578b NF-\u03baB \u548c ERK \u901a\u8def\u7684\u8d1f\u8c03\u63a7\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

AIM2 <\/strong><\/p>\n

AIM2\u901a\u8fc7\u5176\u6b63\u7535\u8377\u7684HIN-200\u7ed3\u6784\u57df\u8bc6\u522b\u53cc\u94feDNA(dsDNA)\uff0c\u5e76\u901a\u8fc7\u5176PYD\u7ed3\u6784\u57df\u62db\u52dfASC\u7528\u4e8ecaspase-1\u7684\u6fc0\u6d3b\u3002<\/p>\n

\u5728AOM\/DSS\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\uff0cAIM2\u7f3a\u9677\u5c0f\u9f20\u66f4\u5bb9\u6613\u53d1\u751f\u80bf\u7624\uff0c\u8fd9\u610f\u5473\u7740AIM2\u5177\u6709\u6297\u80bf\u7624\u4f5c\u7528\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cAIM2\u7f3a\u4e4f\u901a\u8fc7\u5f02\u5e38\u7684Wnt\u4fe1\u53f7\u5bfc\u81f4\u80bf\u7624\u8d77\u59cb\u5e72\u7ec6\u80de\u7684\u589e\u6b96\u3002\u6b64\u5916\uff0cAIM2\u7f3a\u9677\u5c0f\u9f20\u80a0\u9053\u5fae\u751f\u7269\u533a\u7cfb\u7684\u5931\u8c03\u4e5f\u6709\u52a9\u4e8e\u80bf\u7624\u53d1\u751f\u7684\u589e\u5f3a\u3002<\/p>\n

\u53e6\u4e00\u4efd\u62a5\u544a\u8fd8\u63ed\u793a\u4e86AIM2\u5728AOM\/DSS\u548cAPCmin<\/sup>\u4e24\u79cd\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\u7684\u4fdd\u62a4\u4f5c\u7528\u3002\u6709\u8da3\u7684\u662f\uff0cAIM2\u53ef\u4ee5\u4e0eDNA-PKcs\u76f8\u4e92\u4f5c\u7528\uff0c\u963b\u65adAkt\u901a\u8def\u7684\u6fc0\u6d3b\uff0c\u4fc3\u8fdb\u80bf\u7624\u53d1\u5c55\u3002<\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e24\u9879\u7814\u7a76\u90fd\u8ba4\u4e3aAIM2\u7684\u80bf\u7624\u6291\u5236\u6d3b\u6027\u4e0e\u5176\u5728\u708e\u75c7\u5c0f\u4f53\u6fc0\u6d3b\u4e2d\u7684\u4f5c\u7528\u65e0\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

ASC <\/strong><\/p>\n

ASC \u662f\u4e00\u79cd\u53cc\u5411\u9002\u914d\u86cb\u767d\uff0c\u5728 AIM2 \u548c\u5927\u591a\u6570 NLRs \u6fc0\u6d3b\u65f6\u5f62\u6210\u6591\u70b9\uff0c\u5e76\u901a\u8fc7\u5176 CARD \u7ed3\u6784\u57df\u4e0e caspase-1 \u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4 caspase-1 \u6fc0\u6d3b\u3002<\/p>\n

ASC \u7f3a\u5931\u7684\u5c0f\u9f20\u5728 AOM\/DSS \u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\u663e\u793a\u80bf\u7624\u53d1\u751f\u589e\u52a0\uff0c\u800c\u4e14\u6bd4 NLRP3 \u7f3a\u5931\u7684\u5c0f\u9f20\u80bf\u7624\u53d1\u751f\u66f4\u4e25\u91cd\uff0c\u4f46 ASC \u6d3b\u6027\u7684\u786e\u5207\u673a\u5236\u548c\u5206\u533a\u4ecd\u96be\u4ee5\u786e\u5b9a\u3002<\/p>\n

\u53e6\u4e00\u4efd\u62a5\u544a\u663e\u793a\uff0cASC\u7f3a\u9677\u5c0f\u9f20\u5728AOM\/DSS\u8bf1\u5bfc\u7684\u7ed3\u80a0\u764c\u6a21\u578b\u4e2d\u7684\u6613\u611f\u6027\u53ef\u901a\u8fc7\u540c\u7fa4\u9972\u517b\u4f20\u9012\uff0c\u8fd9\u8868\u660e\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u4e0eNLRP6\u7f3a\u9677\u5c0f\u9f20\u7684\u53c2\u4e0e\u65b9\u5f0f\u76f8\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728 DMBA\/TPA \u76ae\u80a4\u81f4\u764c\u6a21\u578b\u4e2d\uff0cASC \u4ee5\u7ec6\u80de\u7c7b\u578b\u7279\u5f02\u6027\u7684\u65b9\u5f0f\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n

\u9ad3\u7cfb\u7ec6\u80de\u7f3a\u4e4f ASC \u4f1a\u5bfc\u81f4\u80bf\u7624\u8d1f\u8377\u51cf\u5c11\uff0c\u8fd9\u8868\u660e ASC \u5177\u6709\u4fc3\u80bf\u7624\u4f5c\u7528\u3002\u80bf\u7624\u751f\u957f\u53d7\u963b\u7684\u540c\u65f6\uff0cIL-1\u03b1\u3001IL-1\u03b2\u3001TNF-\u03b1\u548cIL-6\u7b49\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u4e5f\u51cf\u5c11\u4e86\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u8868\u76ae\u7279\u5f02\u6027 ASC \u7f3a\u4e4f\u7684\u5c0f\u9f20\u4f1a\u7f79\u60a3\u66f4\u4e25\u91cd\u7684\u80bf\u7624\uff0c\u800c ASC \u53ef\u80fd\u901a\u8fc7\u6fc0\u6d3b p53 \u6765\u8c03\u8282\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u8fd9\u4e0e\u708e\u6027\u4f53\u7684\u6d3b\u6027\u65e0\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

25.2 <\/strong>\u7ed3\u675f\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u6211\u4eec\u91cd\u70b9\u63a2\u8ba8\u4e86\u5148\u5929\u6027\u514d\u75ab\u53d7\u4f53\u5728\u80bf\u7624\u514d\u75ab\u8c03\u8282\u4e2d\u7684\u4f5c\u7528\u3002\u514d\u75ab\u7cfb\u7edf\u672c\u8d28\u4e0a\u662f\u4e00\u628a\u53cc\u5203\u5251\uff0c\u867d\u7136\u5b83\u901a\u8fc7\u6d88\u9664\u4e0d\u826f\u5b9e\u4f53\uff08\u5206\u5b50\u3001\u75c5\u539f\u4f53\u548c\u764c\u7ec6\u80de\uff09\u5bf9\u5bbf\u4e3b\u7684\u7a33\u6001\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u5f53\u5b83\u5931\u8c03\u65f6\u4e5f\u4f1a\u5bfc\u81f4\u5404\u79cd\u6709\u5bb3\u4e8b\u4ef6\u3002<\/p>\n

\u7531\u4e8e\u5148\u5929\u6027\u514d\u75ab\u53d7\u4f53\u7684\u6fc0\u6d3b\u901a\u5e38\u4f1a\u5f15\u8d77\u708e\u75c7\u53cd\u5e94\uff0c\u800c\u708e\u75c7\u53cd\u5e94\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6297\u80bf\u7624\u53cd\u5e94\u6216\u4fc3\u80bf\u7624\u53cd\u5e94\uff0c\u56e0\u6b64\u5982\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e9b\u53d7\u4f53\u5728\u8c03\u8282\u80bf\u7624\u53d1\u751f\u65b9\u9762\u7684\u4f5c\u7528\u662f\u591a\u53d8\u7684\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u968f\u7740\u6211\u4eec\u5bf9\u8fd9\u4e9b\u5148\u5929\u6027\u53d7\u4f53\u5982\u4f55\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528\u7684\u8ba4\u8bc6\u4e0d\u65ad\u52a0\u6df1\uff0c\u6211\u4eec\u6709\u5fc5\u8981\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u4ee5\u5bfb\u6c42\u901a\u8fc7\u5229\u7528\u8fd9\u4e9b\u53d7\u4f53\u6765\u6cbb\u7597\u764c\u75c7\u7684\u66f4\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n

I \u578b IFN \u7cfb\u7edf\u7684\u6297\u80bf\u7624\u6d3b\u6027\u5df2\u4e3a\u4eba\u6240\u77e5\u6570\u5341\u5e74\uff0c\u5982\u4eca\u53c8\u88ab “\u91cd\u65b0\u5ba1\u89c6”\uff0c\u8fd9\u53ef\u80fd\u5c24\u5176\u4ee4\u4eba\u611f\u5174\u8da3\u3002\u6709\u8bc1\u636e\u8868\u660e\uff0cI\u578bIFN\u53c2\u4e0e\u4e86\u8fc5\u901f\u5d1b\u8d77\u7684\u764c\u75c7\u68c0\u67e5\u70b9\u7597\u6cd5\u9886\u57df\u3002<\/p>\n

\u6b64\u5916\uff0cIRF7-IFN-\u03b2 \u901a\u8def\u4f3c\u4e4e\u5bf9\u6700\u4f73\u6297\u80bf\u7624\u6d3b\u6027\u81f3\u5173\u91cd\u8981\u3002\u56e0\u6b64\uff0c\u4e00\u79cd\u53ef\u80fd\u7684\u65b9\u6cd5\u662f\u5f00\u53d1\u80fd\u9009\u62e9\u6027\u6fc0\u6d3b\u5148\u5929\u53d7\u4f53\u4ee5\u8bf1\u5bfc I \u578b IFNs \u7684\u6fc0\u52a8\u5242\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u663e\u7136\uff0c\u6211\u4eec\u53ef\u4ee5\u671f\u5f85\u8fdb\u4e00\u6b65\u7684\u5de5\u4f5c\u5c06\u5e26\u6765\u66f4\u597d\u7684\u65b9\u6cd5\uff0c\u6765\u5229\u7528\u5148\u5929\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u529b\u91cf\u6765\u6cbb\u7597\u764c\u75c7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u4f5c\u8005 | <\/span>Sho Hangai, Yoshitaka Kimura,Tadatsugu Taniguchi, and Hideyuki Yanai<\/span><\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u6e29\u946b<\/span><\/p>\n

\u7f16\u8f91\u6392\u7248<\/span> | \u5415\u601d\u8d24<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764 \u80e1\u73ca<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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