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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c26\u7ae0\uff1aCD137\u3001OX40\u3001GITR\u548cCD27\u5171\u523a\u6fc0\u5206\u5b50\u6fc0\u52a8\u5242\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\uff08\u4e0b\uff09<\/span><\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd1\u5e74\u6765\uff0c\u79d1\u5b66\u754c\u8d8a\u6765\u8d8a\u8ba4\u8bc6\u5230\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u5bf9\u5bbf\u4e3b\u5065\u5eb7\u548c\u75c5\u7406\u751f\u7406\u7684\u91cd\u8981\u5f71\u54cd\u3002\u80a0\u9053\u83cc\u7fa4\u6267\u884c\u591a\u79cd\u57fa\u7840\u529f\u80fd\uff0c\u5305\u62ec\u964d\u89e3\u8425\u517b\u7269\u8d28\u4ee5\u63d0\u4f9b\u80fd\u91cf\u3001\u6e05\u9664\u5916\u6765\u751f\u7269\u3001\u57f9\u517b\u514d\u75ab\u7cfb\u7edf\u3001\u652f\u6301\u80a0\u4e0a\u76ae\u7ec6\u80de\u7684\u751f\u957f\u4e0e\u5206\u5316\u3001\u4fc3\u8fdb\u80a0\u8815\u52a8\u3001\u4ea7\u751f\u6297\u83cc\u80bd\u4ee5\u6839\u9664\u75c5\u539f\u4f53\u5e76\u7ef4\u6301\u5b9a\u690d\u62b5\u6297\u529b\u3002\u80a0\u9053\u662f\u514d\u75ab\u7cfb\u7edf\u4e2d\u6700\u5927\u7684\u90e8\u5206\uff0c\u5b83\u4e0d\u4ec5\u66b4\u9732\u4e8e\u6211\u4eec\u5fc5\u987b\u8010\u53d7\u7684\u98df\u7269\u548c\u5171\u751f\u6297\u539f\uff0c\u8fd8\u662f\u8bb8\u591a\u75c5\u539f\u4f53\u7684\u6f5c\u5728\u5165\u53e3\u3002\u6cbf\u7740\u80c3\u80a0\u9053\u5411\u4e0b\uff0c\u7ec6\u83cc\u6570\u91cf\u9010\u6e10\u589e\u591a\uff0c\u5728\u7ed3\u80a0\u53ef\u8fbe\u6bcf\u6beb\u53471012<\/sup>\u4e2a\u3002\u597d\u6c27\u83cc\u4e3b\u8981\u5b58\u5728\u4e8e\u5c0f\u80a0\u4e0a\u90e8\uff0c\u800c\u538c\u6c27\u83cc\u5219\u5728\u7ed3\u80a0\u4e2d\u5360\u4e3b\u5bfc\u3002\u539a\u58c1\u83cc\u95e8\u3001\u62df\u6746\u83cc\u95e8\u3001\u53d8\u5f62\u83cc\u95e8\u548c\u653e\u7ebf\u83cc\u95e8\u662f\u6700\u5e38\u89c1\u7684\u83cc\u7fa4\uff0c\u53e4\u83cc\u4e5f\u662f\u5176\u6210\u5458\u4e4b\u4e00\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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27.2 \u8bc4\u4f30\u764c\u75c7\u643a\u5e26\u8005\u7684\u80a0\u9053\u5931\u8c03<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Dejea \u7b49\u4eba\u5229\u7528FISH\u548c16S rRNA\u6d4b\u5e8f\u5206\u6790\u4e86\u60a3\u6709\u6216\u672a\u60a3\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u53d7\u8bd5\u8005\u7684\u7ed3\u76f4\u80a0\u9ecf\u819c\uff0c\u53d1\u73b0\u4e86\u7ec6\u83cc\u751f\u7269\u819c\u7684\u5b58\u5728\uff0c\u5c3d\u7ba1\u6ca1\u6709\u53d1\u73b0\u4e00\u81f4\u7684\u7ec6\u83cc\u5c5e\u4e0e\u7ed3\u76f4\u80a0\u764c\u76f8\u5173\u3002\u5176\u4ed6\u5229\u752816S rRNA\u6216\u5b8f\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u7684\u7814\u7a76\u63ed\u793a\u4e86CRC\u60a3\u8005\u4e0e\u5bf9\u7167\u7ec4\u80a0\u9053\u83cc\u7fa4\u7ec4\u6210\u7684\u663e\u8457\u5dee\u5f02\uff0c\u7279\u522b\u662f\u68ad\u6746\u83cc\u548c\u535f\u5549\u5355\u80de\u83cc\u5728CRC\u53d7\u8bd5\u8005\u4e2d\u7684\u60a3\u75c5\u7387\u548c\u6c34\u5e73\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\u3002\u8fd9\u4e9b\u5dee\u5f02\u53ef\u80fd\u53d7\u5230\u7814\u7a76\u4eba\u7fa4\u7684\u996e\u98df\u3001\u836f\u7269\u4f7f\u7528\u4ee5\u53ca\u5b9e\u9a8c\u65b9\u6cd5\u548c\u75c5\u4f8b\u5bf9\u7167\u5339\u914d\u7b49\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u5728\u5f53\u524d\u7684\u5b8f\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u4e2d\uff0c\u65e0\u6cd5\u68c0\u6d4b\u5230\u4f4e\u4e8e10^5\u4e2a\u7ec6\u83cc\/\u514b\u7684\u6d53\u5ea6\u3002\u53ea\u6709\u5927\u7ea615%\u7684\u5df2\u9274\u5b9a\u79cd\u7c7b\u540c\u65f6\u88ab\u57f9\u517b\u7ec4\u548c\u5b8f\u57fa\u56e0\u7ec4\u68c0\u6d4b\u5230\uff0c\u7a81\u51fa\u4e86\u57f9\u517b\u4f9d\u8d56\u65b9\u6cd5\u4e0e\u57f9\u517b\u72ec\u7acb\u65b9\u6cd5\u7684\u4e92\u8865\u6027\u3002\u901a\u8fc7\u57f9\u517b\u6761\u4ef6\u7684\u591a\u6837\u5316\u548c\u57fa\u8d28\u8f85\u52a9\u6fc0\u5149\u89e3\u5438\u7535\u79bb\u98de\u884c\u65f6\u95f4\u8d28\u8c31\uff08MALDI-TOF MS\uff09\u7684\u5e94\u7528\uff0c\u5206\u7c7b\u57fa\u56e0\u7ec4\u5b66\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\u3002\u8fd9\u4e9b\u52aa\u529b\u5c06\u6709\u52a9\u4e8e\u672a\u6765\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\u961f\u5217\u4e2d\u5b9a\u4e49\u201c\u764c\u75c7\u76f8\u5173\u7684\u80a0\u9053\u6307\u7eb9\u201d\uff0c\u8fdb\u4e00\u6b65\u5efa\u7acb\u764c\u75c7\u5bf9\u80a0\u9053\u5931\u8c03\u5f71\u54cd\u7684\u5730\u7406\u5206\u5e03\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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27.3 \u5fae\u751f\u7269\u7ec4\u4e0e\u764c\u75c7\u53d1\u75c5\u7387<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bc4\u5c45\u5728\u80a0\u9053\u53ca\u8eab\u4f53\u5176\u4ed6\u90e8\u4f4d\u7684\u5171\u751f\u5fae\u751f\u7269\u7fa4\u4f53\uff0c\u4f3c\u4e4e\u5728\u80a0\u9053\u548c\u80a0\u5916\u764c\u75c7\u7684\u53d1\u5c55\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f46\u5c1a\u672a\u5b8c\u5168\u7406\u89e3\u7684\u4f5c\u7528\u3002\u5728\u65e0\u83cc\u6761\u4ef6\u4e0b\u6216\u7ecf\u514d\u75ab\u6291\u5236\u3001\u6297\u751f\u7d20\u5904\u7406\u7684\u556e\u9f7f\u7c7b\u52a8\u7269\u4e2d\u8fdb\u884c\u7684\u5f00\u521b\u6027\u7814\u7a76\u663e\u793a\uff0c\u8fd9\u4e9b\u5fae\u751f\u7269\u5728\u80bf\u7624\u5f62\u6210\u8fc7\u7a0b\u4e2d\u6709\u4e0d\u5bb9\u5ffd\u89c6\u7684\u5f71\u54cd\uff0c\u4e0d\u8bba\u708e\u75c7\u662f\u5426\u5b58\u5728\u3002\u5728\u7ed3\u80a0\u764c\u6216\u809d\u764c\u7684\u53d1\u5c55\u4e2d\uff0c\u5fae\u751f\u7269\u53ef\u901a\u8fc7\u4ea7\u751f\u6709\u6bd2\u4ee3\u8c22\u7269\u3001\u81f4\u764c\u7269\u6216\u8bf1\u5bfc\u708e\u75c7\u73af\u5883\uff08\u6700\u7ec8\u5bfc\u81f4\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u3001DNA\u635f\u4f24\u54cd\u5e94\u6216\u514d\u75ab\u9003\u9038\uff09\u76f4\u63a5\u4fc3\u8fdb\u764c\u53d8\u3002\u5171\u751f\u5fae\u751f\u7269\u8fd8\u53ef\u80fd\u901a\u8fc7\u5f62\u6210\u534f\u540c\u7684\u751f\u7269\u819c\uff0c\u4fc3\u8fdb\u4ea4\u53c9\u8425\u517b\u6216\u4ee3\u8c22\u4f5c\u7528\uff0c\u91cd\u65b0\u5b9a\u4e49\u764c\u75c7\u5fae\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u80a0\u9053\u5916\uff08\u5982\u4e73\u817a\u548c\u5375\u5de2\uff09\u80bf\u7624\u7684\u53d1\u5c55\u4e0e\u7531\u80a0\u9053\u5fae\u751f\u7269\u5f15\u53d1\u7684\u3001TLR5\u4ecb\u5bfc\u7684\u5168\u8eab\u6027\u708e\u75c7\u6709\u5173\uff0c\u8fd9\u79cd\u708e\u75c7\u901a\u5e38\u7531IL-6\u6216IL-17\u9a71\u52a8\u3002\u76f8\u5bf9\u5730\uff0c\u4e5f\u6709\u7814\u7a76\u8868\u660e\u7ec6\u83cc\u5728\u5bf9\u6297\u764c\u75c7\u65b9\u9762\u53ef\u80fd\u53d1\u6325\u6709\u76ca\u4f5c\u7528\u3002\u4f8b\u5982\uff0c\u5ef6\u957f\u4f7f\u7528\u7532\u785d\u5511\u548c\u73af\u4e19\u6c99\u661f\u7684\u6297\u751f\u7d20\u6cbb\u7597\u5728HER2\/neu\u57fa\u56e0\u9a71\u52a8\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u4e2d\u4f7f\u4e73\u817a\u764c\uff08BC\uff09\u7684\u53d1\u75c5\u7387\u589e\u52a0\u4e86\u4e09\u500d\u3002\u5728\u4eba\u7c7b\u4e2d\uff0c\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8868\u660e\u6297\u751f\u7d20\u4f7f\u7528\u4e0e\u4e73\u817a\u764c\u98ce\u9669\u4e4b\u95f4\u5b58\u5728\u5242\u91cf\u4f9d\u8d56\u5173\u7cfb\u3002Knekt\u7b49\u4eba\u9996\u6b21\u62a5\u9053\u4e86\u6297\u751f\u7d20\u6444\u5165\u4e0e\u4e73\u817a\u764c\u53d1\u75c5\u7387\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u7814\u7a76\u663e\u793a\uff0c\u5c0f\u4e8e50\u5c81\u7684\u5973\u6027\u62a5\u544a\u4ee5\u524d\u548c\/\u6216\u76ee\u524d\u4f7f\u7528\u6297\u751f\u7d20\u6cbb\u7597\u5c3f\u9053\u611f\u67d3\uff08\u4f46\u6ca1\u6709\u7ec6\u83cc\u5c3f\uff09\u7684\u60c5\u51b5\u4e0b\uff0c\u4e73\u817a\u764c\u98ce\u9669\u589e\u52a0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u591a\u9879\u7814\u7a76\u62a5\u544a\u4e86\u4eba\u4f53\u4e0d\u540c\u5165\u53e3\u5904\u7684\u5c40\u90e8\u5fae\u751f\u7269\u7ec4\u6210\u6539\u53d8\u4e0e\u764c\u75c7\u53d1\u751f\u4e4b\u95f4\u7684\u8054\u7cfb\uff0c\u5982\u5934\u9888\u764c\u4e2d\u7684\u53e3\u8154\u764c\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u7684\u652f\u6c14\u7ba1\u764c\uff0c\u4ee5\u53ca\u80a0\u9053\u548c\u7ed3\u80a0\u6076\u6027\u80bf\u7624\u4e0e\u5bab\u9888\u764c\u4e2d\u7684\u9634\u9053\u764c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u7136\u800c\uff0c\u8fd9\u4e9b\u7814\u7a76\u5f80\u5f80\u5b58\u5728\u7f3a\u9677\u6216\u504f\u89c1\uff1a(a) \u7f3a\u4e4f\u4e25\u683c\u7684\u65b9\u6cd5\u5b66\uff0c\u5982PCR\u300116S \u7126\u78f7\u9178\u6d4b\u5e8f\u5206\u6790\u3001\u6df1\u5ea6\u6d4b\u5e8f\uff08\u5b8f\u57fa\u56e0\u7ec4\u5b66\uff09\u3001\u6587\u5316\u7ec4\u5b66\uff1b(b) \u5ffd\u89c6\u4e86\u53ef\u80fd\u72ec\u7acb\u589e\u52a0\u764c\u75c7\u98ce\u9669\u7684\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\uff0c\u5982\u793e\u4f1a\u73af\u5883\u3001\u4e45\u5750\u4e0d\u52a8\u7684\u751f\u6d3b\u65b9\u5f0f\u3001\u8425\u517b\u4e0d\u826f\u3001\u9157\u9152\u6216\u5438\u70df\u884c\u4e3a\uff1b(c) \u7f3a\u4e4f\u9a8c\u8bc1\u961f\u5217\uff08\u6839\u636eREMARK\u6807\u51c6\uff09\uff1b(d) \u5fae\u751f\u7269\u4f18\u52bf\u4e0e\u6f5c\u5728\u7684\u75c5\u7406\u751f\u7406\u4e4b\u95f4\u7f3a\u4e4f\u660e\u786e\u7684\u56e0\u679c\u5173\u7cfb\u3002\u5f53\u524d\u5bf9\u80a0\u9053\u83cc\u7fa4\u5bf9\u764c\u75c7\u5f71\u54cd\u7684\u7814\u7a76\u5c06\u6fc0\u52b1\u4e34\u5e8a\u533b\u751f\u5f00\u5c55\u524d\u77bb\u6027\u7814\u7a76\uff0c\u8bc4\u4f30\u6297\u751f\u7d20\u4f7f\u7528\u3001\u8425\u517b\u3001\u9057\u4f20\u548c\u73af\u5883\u56e0\u7d20\u5728\u9a71\u52a8\u6216\u5f71\u54cd\u80bf\u7624\u53d1\u751f\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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27.4 \u653e\u5c04\u6cbb\u7597\u4e0e\u5fae\u751f\u7269\u7fa4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u653e\u5c04\u6cbb\u7597\u5bf9\u5fae\u751f\u7269\u7fa4\u53ca\u5176\u5728\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e2d\u7684\u5f71\u54cd\u5c1a\u672a\u88ab\u5e7f\u6cdb\u7814\u7a76\u3002\u76ee\u524d\u5927\u90e8\u5206\u7814\u7a76\u96c6\u4e2d\u5728\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u9053\u635f\u4f24\u53ca\u5176\u7531\u5bbf\u4e3b\u5fae\u751f\u7269\u7ec4\u8c03\u63a7\u7684\u5f71\u54cd\u4e0a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Crawford \u7b49\u4eba\u9996\u6b21\u62a5\u544a\u6307\u51fa\uff0c\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u662f\u8f90\u5c04\u8bf1\u5bfc\u7684\u80a0\u9053\u635f\u4f24\u7684\u4e00\u4e2a\u5173\u952e\u8c03\u8282\u56e0\u5b50\uff0c\u7814\u7a76\u663e\u793a\u65e0\u83cc\u52a8\u7269\u5bf9\u8f90\u5c04\u6027\u80a0\u708e\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u62b5\u6297\u529b\u3002\u8f90\u5c04\u663e\u8457\u6539\u53d8\u4e86\u5c0f\u9f20\u4f53\u5185\u7684\u5fae\u751f\u7269\u7ec4\u6210\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u5168\u8eab\u7167\u5c04\u540e\uff0c\u901a\u8fc7\u7caa\u4fbf\u5fae\u751f\u7269\u79fb\u690d\uff08FMT\uff09\u8c03\u8282\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u53ef\u4ee5\u63d0\u9ad8\u751f\u5b58\u7387\uff0c\u5e76\u901a\u8fc7\u523a\u6fc0\u8840\u7ba1\u751f\u6210\u90e8\u5206\u6062\u590d\u80a0\u4e0a\u76ae\u7684\u5b8c\u6574\u6027\u3002TLR\u4fe1\u53f7\u901a\u8def\u53ef\u80fd\u5728\u8f90\u5c04\u5bf9\u80a0\u9053\u7684\u4fdd\u62a4\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Ciorba \u7b49\u4eba\u5728\u8f90\u5c04\u8bf1\u5bfc\u7684\u80a0\u635f\u4f24\u7684\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u53d1\u73b0\uff0c\u4e73\u9178\u83cc\u901a\u8fc7TLR2\u4ee5\u53ca\u8868\u8fbeCOX-2\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7684\u8fc1\u79fb\u53d1\u6325\u4fdd\u62a4\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u4e34\u5e8a\u7814\u7a76\u4e5f\u62a5\u9053\u4e86\u8f90\u5c04\u8bf1\u5bfc\u80a0\u635f\u4f24\u540e\u80a0\u9053\u83cc\u7fa4\u7684\u53d8\u5316\u3002Wang \u7b49\u4eba\u53d1\u73b0\uff0c\u76c6\u8154\u7167\u5c04\u8bf1\u53d1\u60a3\u8005\u80a0\u9053\u708e\u75c7\u6807\u5fd7\u7269\u7684\u91ca\u653e\uff0c\u4e0e\u4e4f\u529b\u76f8\u5173\u3002\u8f83\u4f4e\u7684\u80a0\u9053\u5fae\u751f\u7269\u591a\u6837\u6027\u540c\u6837\u9884\u793a\u7740\u8f90\u5c04\u8bf1\u5bfc\u7684\u7ed3\u80a0\u708e\u7684\u53d1\u5c55\u3002Demers \u7b49\u4eba\u7684\u7814\u7a76\u8868\u660e\uff0c\u53cc\u6b67\u6746\u83cc\/\u4e73\u9178\u6746\u83cc\u663e\u8457\u964d\u4f4e\u8179\u6cfb\u7684\u53d1\u751f\u3002\u7136\u800c\uff0c\u6ca1\u6709\u5355\u4e00\u7684\u7ec6\u83cc\u83cc\u682a\u88ab\u4e00\u81f4\u8ba4\u4e3a\u5bf9\u8f90\u5c04\u5f15\u8d77\u7684\u80a0\u635f\u4f24\u6709\u76ca\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5fae\u751f\u7269\u7fa4\u5728\u653e\u5c04\u6cbb\u7597\u6548\u679c\u4e2d\u7684\u79ef\u6781\u4f5c\u7528\u4ecd\u9700\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002\u6709\u7406\u7531\u76f8\u4fe1\uff0c\u7834\u574f\u7c98\u819c\u5c4f\u969c\u548c\u4fc3\u8fdb\u9ecf\u819c\u5fae\u751f\u7269\u7684\u6613\u4f4d\u53ef\u80fd\u6fc0\u6d3b\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u3002Paulos \u7b49\u4eba\u9996\u6b21\u62a5\u544a\u4e86\u8fd9\u4e00\u53d1\u73b0\uff0c\u4ed6\u4eec\u8868\u660e\u5168\u8eab\u7167\u5c04\u4fc3\u8fdb\u4e86\u4f9d\u8d56\u4e8eLPS-TLR4\u7684\u6297\u539f\u63d0\u5448\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u589e\u5f3a\u4e86\u8fc7\u7ee7T\u7ec6\u80de\u8f6c\u79fb\u7684\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8f90\u5c04\u8bf1\u5bfc\u7684\u80a0\u635f\u4f24\u4fc3\u8fdb\u5171\u751f\u7ec6\u83cc\u7684\u6613\u4f4d\u548cLPS\u7684\u91ca\u653e\uff0c\u8fd9\u5bfc\u81f4\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u6fc0\u6d3b\u548c\u8fc7\u7ee7\u8f6c\u79fbT\u7ec6\u80de\u7684\u6d3b\u5316\u3002\u8fd9\u4e00\u8fc7\u7a0b\u4e0e\u6cbb\u7597\u6548\u679c\u53ca\u5728\u5c0f\u9f20\u4e2d\u957f\u671f\u6cbb\u6108\u9ed1\u8272\u7d20\u7624B16F10\u76f8\u5173\u3002\u56e0\u6b64\uff0c\u8c03\u8282\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u4e0e\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u5e73\u8861\u53ef\u80fd\u589e\u5f3a\u7ec6\u80de\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u3002\u7136\u800c\uff0cEspinosa-Carrasco \u7684\u540e\u7eed\u7814\u7a76\u8868\u660e\uff0cLPS\u7684\u6613\u4f4d\u53ea\u80fd\u90e8\u5206\u89e3\u91caPaulos \u7b49\u4eba\u89c2\u5bdf\u5230\u7684\u6548\u679c\u3002\u81f3\u4eca\uff0c\u5c1a\u65e0\u6570\u636e\u652f\u6301\u5fae\u751f\u7269\u7ec4\u6210\u5206\u5728\u653e\u5c04\u514d\u75ab\u6cbb\u7597\u4e2d\u4f5c\u4e3a\u8c03\u8282\u5242\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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27.5 \u73af\u78f7\u9170\u80fa\u4e0e\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7684\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f17\u6240\u5468\u77e5\uff0c\u5316\u7597\u4f1a\u8bf1\u53d1\u7c98\u819c\u708e\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\uff0c\u8fd9\u4e24\u79cd\u4e3b\u8981\u7684\u526f\u4f5c\u7528\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4f7f\u7528\u6297\u751f\u7d20\u5e76\u5bfc\u81f4\u751f\u7269\u5931\u8c03\u3002\u7814\u7a76\u4eba\u5458\u63a2\u8ba8\u4e86\u80a0\u9053\u83cc\u7fa4\u5bf9\u5316\u7597\u836f\u7269\uff0c\u7279\u522b\u662f\u80fd\u591f\u5f71\u54cd\u80a0\u9053\u5185\u7a33\u6001\u7684\u836f\u7269\u7597\u6548\u7684\u5f71\u54cd\u95ee\u9898\u3002\u73af\u78f7\u9170\u80fa(CTX)\u662f\u4e00\u79cddna\u70f7\u57fa\u5316\u5242\uff0c\u5c5e\u4e8e\u6c2e\u5bb6\u65cf\uff0c\u5177\u6709\u514d\u75ab\u8c03\u8282\u548c\u6297\u8840\u7ba1\u751f\u6210\u7684\u7279\u6027\uff0c\u76ee\u524d\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\u3001\u8089\u7624\u548c\u513f\u7ae5\u6076\u6027\u80bf\u7624\u7684\u4e34\u5e8a\uff0c\u5176\u7597\u6548\u53d6\u51b3\u4e8e\u5176\u8bf1\u5bfc\u5c0f\u80a0\u5185\u7684\u9009\u62e9\u6027\u9769\u5170\u6c0f\u9633\u6027\u7ec6\u83cc\u6613\u4f4d\u7684\u80fd\u529b\uff0c\u5982hirrae\u80a0\u7403\u83cc\u6216johnsonii\u4e73\u6746\u83cc\u8fdb\u5165\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\u3002\u4e8b\u5b9e\u4e0a\uff0cCTX\u8d1f\u8d23\u7834\u574f\u80a0\u9053\u5c4f\u969c\u7684\u5b8c\u6574\u6027\u548c\u80a0\u9053\u5185\u7a33\u6001(\u5305\u62ec\u4e0a\u76ae\u548c\u514d\u75ab\u9694\u5ba4)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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CTX\u6cbb\u7597\u7684\u60a3\u8005\u80a0\u9053\u5c4f\u969c\u8f83\u5f31\uff0c\u8fd9\u6253\u7834\u4e86\u5bf9\u80a0\u9053\u83cc\u7fa4\u7684\u8010\u53d7\u6027\uff0c\u5bfc\u81f4\u5176\u5bf9\u67d0\u4e9b\u83cc\u682a\u514d\u75ab\u3002\u8fd9\u79cd\u514d\u75ab\u662f\u7531CD4+<\/sup>\u6548\u5e94\u6dcb\u5df4\u7ec6\u80de\u201c\u81f4\u75c5Th17\u201d\u4ea7\u751fIFN\u03b3\u548cIL-17\uff0c\u5e2e\u52a9\u80bf\u7624\u6d78\u6da6Th1\u6dcb\u5df4\u7ec6\u80de\u63a7\u5236\u5c0f\u9f20\u80bf\u7624\u751f\u957f\u3002\u6709\u8da3\u7684\u662f\uff0c\u5e7f\u8c31\u6297\u751f\u7d20\u4ee5\u53ca\u4e07\u53e4\u9709\u7d20(\u4e3b\u8981\u6740\u6b7b\u9769\u5170\u6c0f\u9633\u6027\u83cc)\u548c\u7c98\u83cc\u7d20(\u4e3b\u8981\u6d88\u9664\u9769\u5170\u6c0f\u9634\u6027\u83cc)\u90fd\u635f\u5bb3\u4e86pTh17\u5728\u813e\u810f\u4e2d\u7684\u6781\u6027\uff0c\u4ee5\u53caCTX\u5728P815\u4e73\u817a\u7ec6\u80de\u7624\u548cMCA205\u8089\u7624\u5c0f\u9f20\u4f53\u5185\u7684\u5168\u9762\u6297\u764c\u6d3b\u6027\uff0c\u652f\u6301\u4e86\u73af\u78f7\u9170\u80fa\u7684\u529f\u6548\u4e0e\u83cc\u7fa4\u6709\u5173\u7684\u7684\u89c2\u70b9\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728\u6613\u4f4d\u9769\u5170\u6c0f\u9633\u6027\u7ec6\u83cc\u4e2d\uff0chirae\u8bf1\u5bfcTh17\u548cTh1 CD4+ <\/sup>T\u6dcb\u5df4\u7ec6\u80de\uff0c\u5e76\u523a\u6fc0\u80bf\u7624\u7279\u5f02\u6027CD8+ T\u7ec6\u80de\uff0c\u56e0\u4e3a\u5b83\u51cf\u5c11\u4e86\u514d\u75ab\u6291\u5236\u7624\u5185treg\u548c\u4ea7\u751fil -17\u7684\u03b3\u03b4 T\u7ec6\u80de(Fig 27.1<\/span>)\u3002\u6297\u751f\u7d20\u5904\u7406\u7684\u5c0f\u9f20\u4e0ehirai\u5927\u80a0\u6746\u83cc\u7684\u5355\u4e00\u8054\u5408\u4f5c\u7528\u5927\u5927\u63d0\u9ad8\u4e86CTX\u5bf9\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u4f5c\u7528\uff0c\u8fd9\u79cd\u4f5c\u7528\u88ab\u6d88\u8017CD8+<\/sup> T\u7ec6\u80de\u6216\u4e2d\u548cIFN\u03b3\u7684\u6297\u4f53\u6240\u963b\u65ad\uff0c\u8fd9\u8868\u660e\u5b83\u9700\u8981\u6297\u764c\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 27.1<\/span> E. hirae\u7684\u514d\u75ab\u539f\u6027\u3002\u5728\u5927\u7ea625%\u7684\u4e2a\u4f53\u4e2d\uff0cE. hirae\u5bc4\u5c45\u5728\u7a7a\u80a0\u548c\u7ed3\u80a0\u4e2d\u3002\u5728\u53e4\u65af\u5854\u592b\u00b7\u9c81\u897f\u7ef4\u52d2\u8ba9\u592b\u7684\u9f20\u80a0\u9053\u4e2d\uff0c\u8fd9\u79cd\u80a0\u7403\u83cc\u975e\u5e38\u5360\u4f18\u52bf\u3002\u8fd9\u79cd\u80a0\u7403\u83cc\u4e0d\u5177\u75c5\u539f\u6027\uff0c\u5e76\u4e14\u5f97\u76ca\u4e8e\u73af\u78f7\u9170\u80fa\u4ecb\u5bfc\u7684\u80a0\u9053\u901a\u900f\u6027\u589e\u52a0\uff0c\u80fd\u591f\u8f6c\u79fb\u5230\u6b21\u7ea7\u6dcb\u5df4\u5668\u5b98\uff0c\u6fc0\u6d3b\u7279\u5b9a\u7684\u81f4\u75c5\u6027CXCR3+ CCR3+ T\u7ec6\u80de\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u8fc1\u79fb\u5230\u80bf\u7624\u75c5\u53d8\u5904\uff0c\u5e76\u91cd\u65b0\u7f16\u7a0b\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5373\u51cf\u5c11\u8c03\u8282\u6027T\u7ec6\u80de\u548c\u03b3\u03b4T17\u7ec6\u80de\uff0c\u589e\u5f3a\u9488\u5bf9\u764c\u75c7\u7684CTL\u53cd\u5e94\u3002E. hirae\u8fd8\u4f5c\u7528\u4e8e\u80a0\u4e0a\u76ae\u7ec6\u80de\uff0c\u4ee5NOD2\u4f9d\u8d56\u7684\u65b9\u5f0f\u8c03\u8282\u51cb\u4ea1\u548cIL-18\u5206\u6ccc\u3002\u9aa8\u9ad3\u6811\u7a81\u72b6\u7ec6\u80de\u8bc6\u522bE. hirae\uff0c\u4ee5NOD2\u4f9d\u8d56\u7684\u65b9\u5f0f\u8bf1\u5bfcIL-12\u548cIL-27\u7684\u4ea7\u751f\u3002\u6240\u6709\u8fd9\u4e9b\u7279\u6027\u5171\u540c\u53c2\u4e0e\u5176\u4f50\u5242\u6548\u5e94\uff0c\u589e\u5f3a\u73af\u78f7\u9170\u80fa\u4ecb\u5bfc\u7684\u514d\u75ab\u6fc0\u6d3b\u80fd\u529b\u548c\u6297\u764c\u6548\u679c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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27.6 \u94c2\u76d0\u4e0e\u80a0\u9053\u83cc\u7fa4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Giorgio Trinchieri \u535a\u58eb\u7684\u7814\u7a76\u5c0f\u7ec4\u6307\u51fa\u4e86\u80a0\u9053\u83cc\u7fa4\u5bf9\u6297\u764c\u836f\u7269\u529f\u6548\u7684\u91cd\u8981\u5f71\u54cd\u3002Iida \u7b49\u4eba\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728\u57fa\u4e8e\u94c2\u7c7b\u7684\u6297\u764c\u6cbb\u7597\u4e2d\uff0c\u80bf\u7624\u6d78\u6da6\u7684\u9aa8\u9ad3\u7ec6\u80de\u4ea7\u751f\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u4ecb\u5bfc\u7684\u6297\u80bf\u7624\u4f5c\u7528\u4e0e\u7ec6\u83cc\u5b58\u5728\u5173\u8054\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u94c2\u76d0\uff08\u5305\u62ec\u5965\u6c99\u5229\u94c2\u548c\u987a\u94c2\uff09\u7684\u7597\u6548\u4f9d\u8d56\u4e8e\u80bf\u7624\u5185\u9ad3\u7cfb\u7ec6\u80de\uff08\u5305\u62ec\u9ad3\u7cfb\u6291\u5236\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u548c\u672a\u6210\u719f\u6811\u7a81\u72b6\u7ec6\u80de\uff09\u901a\u8fc7\u4f9d\u8d56MyD88\u7684\u673a\u5236\u4ea7\u751f\u6d3b\u6027\u6c27\u3002\u6d3b\u6027\u6c27\u5f15\u53d1DNA\u635f\u4f24\uff0c\u8fdb\u800c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80deDNA\u52a0\u5408\u7269\u7684\u5f62\u6210\u548c\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fd9\u662f\u5965\u6c99\u5229\u94c2\u5728MC38\u6216EL4\u8377\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\u90e8\u5206\u6740\u4f24\u6d3b\u6027\u7684\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6709\u8da3\u7684\u662f\uff0c\u7814\u7a76\u53d1\u73b0\u4e0e\u65e0\u7279\u5b9a\u75c5\u539f\u4f53\uff08SPF\uff09\u52a8\u7269\u76f8\u6bd4\uff0c\u65e0\u83cc\u6216\u63a5\u53d7\u6297\u7ed3\u6838\u6cbb\u7597\u7684\u5c0f\u9f20\u4e2d\u5316\u7597\u6548\u679c\u4e0d\u660e\u663e\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u63a2\u8ba8\u4e86\u6297\u7ed3\u6838\u6cbb\u7597\u5bf9\u5965\u6c99\u5229\u94c2\u4ecb\u5bfc\u7684ROS\u4ea7\u751f\u7684\u5f71\u54cd\uff0c\u53d1\u73b0\u7f16\u7801\u6d3b\u6027\u6c27\u751f\u6210\u9176NOX2\u7684Cybb\u57fa\u56e0\u8868\u8fbe\u5728\u63a5\u53d7\u6297\u7ed3\u6838\u6cbb\u7597\u7684\u5c0f\u9f20\u4e2d\u88ab\u6291\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u5f53\u4f7f\u7528\u55dc\u9178\u4e73\u6746\u83cc\u5bf9\u8fd9\u4e9b\u5c0f\u9f20\u8fdb\u884c\u5fae\u751f\u7269\u8865\u507f\u540e\uff0c\u6062\u590d\u4e86\u57fa\u4e8e\u987a\u94c2\u7684\u5316\u7597\u6548\u679c\uff0c\u5e76\u91cd\u5efa\u4e86\u4e0e\u987a\u94c2\u529f\u80fd\u76f8\u5173\u7684\u708e\u75c7\u57fa\u56e0\u8868\u8fbe\u3002\u603b\u4f53\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7ed3\u679c\u652f\u6301\u4e86\u4e00\u4e2a\u89c2\u70b9\uff1a\u80a0\u9053\u83cc\u7fa4\u901a\u8fc7\u5f71\u54cd\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u6c27\u5316\u8fd8\u539f\u5e73\u8861\uff0c\u8fdb\u800c\u5f71\u54cd\u5f53\u524d\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u94c2\u76d0\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u7f57\u8377<\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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