{"id":3589,"date":"2024-06-08T17:04:26","date_gmt":"2024-06-08T09:04:26","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2024\/06\/08\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac29%e7%ab%a0-%e5%87%8f%e5%b0%91%e8%82%bf%e7%98%a4%e5%86%85%e8%b0%83%e8%8a%82%e6%80%a7t%e7%bb%86%e8%83%9e%e7%9a%84%e7%ad%96%e7%95%a5%ef%bc%88\/"},"modified":"2024-06-08T17:04:26","modified_gmt":"2024-06-08T09:04:26","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac29%e7%ab%a0-%e5%87%8f%e5%b0%91%e8%82%bf%e7%98%a4%e5%86%85%e8%b0%83%e8%8a%82%e6%80%a7t%e7%bb%86%e8%83%9e%e7%9a%84%e7%ad%96%e7%95%a5%ef%bc%88","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2024\/06\/08\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac29%e7%ab%a0-%e5%87%8f%e5%b0%91%e8%82%bf%e7%98%a4%e5%86%85%e8%b0%83%e8%8a%82%e6%80%a7t%e7%bb%86%e8%83%9e%e7%9a%84%e7%ad%96%e7%95%a5%ef%bc%88\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c29\u7ae0 \u51cf\u5c11\u80bf\u7624\u5185\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u7b56\u7565\uff08\u4e0a\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c28\u7ae0\uff1a\u80bf\u7624\u7684\u5c40\u90e8\u514d\u75ab\u6cbb\u7597\uff08\u4e0b\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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29.1 \u5f15\u8a00<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.1.1  \u5c0f\u9f20\u548c\u4eba\u6e90\uff08\u9f20\u6e90\u548c\u4eba\u6e90\uff09Treg\u7ec6\u80de\u7684\u7279\u5f81<\/p>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u5728\u7ef4\u6301\u81ea\u8eab\u514d\u75ab\u8010\u53d7\u548c\u514d\u75ab\u7cfb\u7edf\u7684\u52a8\u6001\u5e73\u8861\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u8fd9\u7c7b\u7ec6\u80de\u901a\u8fc7\u591a\u79cd\u673a\u5236\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u52a9\u63a8\u80bf\u7624\u9003\u907f\u514d\u75ab\u76d1\u89c6\uff0c\u4ece\u800c\u6709\u5229\u4e8e\u80bf\u7624\u7684\u751f\u957f\u548c\u6269\u6563\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Treg\u7684\u5173\u952e\u6807\u5fd7\u662f\u8f6c\u5f55\u56e0\u5b50FoxP3\u7684\u8868\u8fbe\uff0c\u5b83\u5bf9Treg\u7684\u53d1\u80b2\u548c\u529f\u80fd\u81f3\u5173\u91cd\u8981\u3002\u5728\u5c0f\u9f20\u4e2d\uff0cTreg\u7ec6\u80de\u4f1a\u6301\u7eed\u8868\u8fbeFoxP3\uff0c\u800c\u5728\u4eba\u7c7b\u4e2d\uff0cTreg\u7684FoxP3\u8868\u8fbe\u5219\u4e0d\u5fc5\u7136\uff0c\u4e14\u6fc0\u6d3b\u7684\u4f20\u7edfT\u7ec6\u80de\uff08Tconv\uff09\u5728\u67d0\u4e9b\u6761\u4ef6\u4e0b\u4e5f\u53ef\u80fd\u6682\u65f6\u8868\u8fbe\u4e2d\u7b49\u6c34\u5e73\u7684FoxP3\u3002\u56e0\u6b64\uff0c\u4eba\u7c7bTreg\u7684\u8bc6\u522b\u66f4\u4e3a\u590d\u6742\uff0c\u6d89\u53ca\u591a\u79cd\u6807\u5fd7\u7269\u7684\u7ec4\u5408\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u4eba\u7c7bTreg\u53ef\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u88ab\u8bc6\u522b\u4e3aCD3+<\/sup>\u3001CD4+<\/sup>\u3001\u9ad8\u8868\u8fbeCD25\u4e14\u4f4e\u8868\u8fbeCD127\u7684\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u65e0\u8bba\u662f\u5728\u5c0f\u9f20\u8fd8\u662f\u4eba\u7c7b\u4e2d\uff0cTreg\u5747\u80fd\u8868\u8fbe\u591a\u79cd\u6291\u5236\u6027\u53d7\u4f53\uff0c\u5982CTLA-4\u3001PD-1\u548cLag-3\u3002\u5b83\u4eec\u8fd8\u8868\u8fbe\u4e00\u4e9b\u5171\u523a\u6fc0\u53d7\u4f53\uff0c\u5982\u7cd6\u76ae\u8d28\u6fc0\u7d20\u8bf1\u5bfc\u7684\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u86cb\u767d\uff08GITR\uff09\u548cOX40\uff08\u4e5f\u79f0CD134\uff09\uff0c\u4ee5\u53ca\u5176\u4ed6\u91cd\u8981\u7684\u8868\u9762\u6807\u8bb0\u7269\uff0c\u5982\u53ef\u8bf1\u5bfc\u5171\u523a\u6fc0\u5206\u5b50\uff08ICOS\uff09\u3001\u80de\u5916\u6838\u82f7\u9178\u9176CD39\u548cCD79\u3002\u8fd9\u4e9b\u8868\u9762\u5206\u5b50\u7684\u8868\u8fbe\u8d4b\u4e88Treg\u5176\u72ec\u7279\u7684\u8c03\u63a7\u529f\u80fd\uff0c\u4f7f\u5176\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.1.2 Treg\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027<\/p>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027\u662f\u5176\u5173\u952e\u529f\u80fd\uff0c\u4e3b\u8981\u901a\u8fc7\u4ee5\u4e0b\u56db\u79cd\u673a\u5236\u5b9e\u73b0\uff1a<\/p>\n

1. \u7ec6\u80de\u56e0\u5b50\u7684\u91ca\u653e<\/strong>\uff1aTreg\u80fd\u591f\u5206\u6ccc\u591a\u79cd\u5177\u6709\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u5305\u62ec\u767d\u7ec6\u80de\u4ecb\u7d20-10\uff08IL-10\uff09\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\uff08TGF-\u03b2\uff09\u548cIL-35\u3002\u8fd9\u4e9b\u56e0\u5b50\u80fd\u6709\u6548\u6291\u5236\u708e\u75c7\u53cd\u5e94\u548c\u4fc3\u8fdb\u514d\u75ab\u8010\u53d7\u3002
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2. \u7ec6\u80de\u6bd2\u6027\u4f5c\u7528<\/strong>\uff1aTreg\u4e5f\u53ef\u4ee5\u901a\u8fc7\u91ca\u653e\u7ec6\u80de\u6bd2\u6027\u5206\u5b50\u5982\u9897\u7c92\u9176A\u3001\u9897\u7c92\u9176B\u548c\u7a7f\u5b54\u7d20\uff0c\u76f4\u63a5\u6740\u4f24\u9776\u7ec6\u80de\uff0c\u8fd9\u4e00\u673a\u5236\u4e3b\u8981\u9488\u5bf9\u6fc0\u6d3b\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u4ee5\u51cf\u5c11\u514d\u75ab\u53cd\u5e94\u3002
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3. \u4ee3\u8c22\u5e72\u9884<\/strong>\uff1aTreg\u901a\u8fc7\u8868\u9762\u5206\u5b50\u5982CD25\uff08\u9ad8\u4eb2\u548c\u529b\u7684IL-2\u53d7\u4f53\u03b1\u94fe\uff09\u3001CD39\u548cCD73\u7b49\u5916\u5207\u6838\u82f7\u9178\u9176\uff0c\u5e72\u9884\u5176\u4ed6T\u7ec6\u80de\u7684\u4ee3\u8c22\u8fc7\u7a0b\u3002\u8fd9\u4e9b\u5206\u5b50\u7684\u4f5c\u7528\u4e3b\u8981\u662f\u964d\u4f4eIL-2\u7684\u53ef\u7528\u6027\u548c\u589e\u52a0\u7ec6\u80de\u5916\u817a\u82f7\u7684\u6d53\u5ea6\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u7684\u6d3b\u5316\u548c\u589e\u6b96\u3002
<\/p>\n

4. \u8c03\u8282\u6811\u7a81\u72b6\u7ec6\u80de\u529f\u80fd<\/strong>\uff1a\u901a\u8fc7\u5171\u6291\u5236\u53d7\u4f53\u5982CTLA-4\u6216LAG-3\uff0cTreg\u80fd\u591f\u6291\u5236\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u7684\u6d3b\u6027\u3002\u8fd9\u79cd\u4f5c\u7528\u4e0d\u4ec5\u51cf\u5f31\u4e86\u6811\u7a81\u72b6\u7ec6\u80de\u5bf9\u6548\u5e94T\u7ec6\u80de\u7684\u6fc0\u6d3b\u80fd\u529b\uff0c\u8fd8\u589e\u5f3a\u4e86\u514d\u75ab\u8010\u53d7\u73af\u5883\u7684\u5efa\u7acb\u3002
<\/p>\n

\u8fd9\u4e9b\u673a\u5236\u7684\u534f\u540c\u4f5c\u7528\u4f7f\u5f97Treg\u5728\u8c03\u63a7\u514d\u75ab\u53cd\u5e94\u3001\u7ef4\u62a4\u673a\u4f53\u514d\u75ab\u7a33\u5b9a\u4e2d\u53d1\u6325\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.1.3 \u5916\u5468\u8840\u548c\u80bf\u7624\u5fae\u73af\u5883\u4e2dTreg\u7684\u8868\u8fbe\u6c34\u5e73\u5bf9\u80bf\u7624\u9884\u540e\u7684\u5f71\u54cd<\/p>\n<\/section>\n

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\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u5728\u7ef4\u62a4\u81ea\u8eab\u8010\u53d7\u6027\u3001\u9884\u9632\u81ea\u8eab\u514d\u75ab\u75c5\u548c\u63a7\u5236\u6162\u6027\u708e\u75c7\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5728\u80bf\u7624\u75be\u75c5\u7684\u80cc\u666f\u4e0b\uff0cTreg\u7684\u4f5c\u7528\u8f83\u4e3a\u590d\u6742\uff0c\u5176\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\u7684\u8868\u8fbe\u4e0e\u9884\u540e\u4e4b\u95f4\u7684\u5173\u7cfb\u5404\u5f02\u3002<\/p>\n

\u7814\u7a76\u663e\u793a\uff0cTreg\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u7684\u9ad8\u8868\u8fbe\u4e0e\u4e0d\u826f\u9884\u540e\u76f8\u5173\uff0c\u5305\u62ec\u80f0\u817a\u764c\u3001\u809d\u764c\u3001\u80ba\u764c\u3001\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u3002\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0cTreg\u53ef\u80fd\u901a\u8fc7\u6291\u5236\u6709\u6548\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\uff0c\u5e2e\u52a9\u80bf\u7624\u7ec6\u80de\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u76d1\u63a7\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u6269\u6563\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u65b9\u9762\uff0c\u4e00\u4e9b\u8bc1\u636e\u8868\u660e\uff0cTreg\u5728\u67d0\u4e9b\u764c\u75c7\u7c7b\u578b\u5982\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u548c\u5934\u9888\u764c\u4e2d\u53ef\u80fd\u53d1\u6325\u4fdd\u62a4\u4f5c\u7528\uff0c\u8fd9\u53ef\u80fd\u4e0e\u8fd9\u4e9b\u80bf\u7624\u7684\u7279\u5b9a\u514d\u75ab\u73af\u5883\u6709\u5173\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u809b\u95e8\u9cde\u72b6\u7ec6\u80de\u764c\uff0c\u76ee\u524d\u7684\u7814\u7a76\u8868\u660eTreg\u7684\u8868\u8fbe\u6c34\u5e73\u4f3c\u4e4e\u5bf9\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u6ca1\u6709\u663e\u8457\u5f71\u54cd\u3002<\/p>\n

\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86\u5728\u4e0d\u540c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u9488\u5bf9Treg\u7684\u6f5c\u5728\u6cbb\u7597\u7b56\u7565\u9700\u8981\u56e0\u80bf\u7624\u7c7b\u578b\u800c\u5f02\uff0c\u4ee5\u4f18\u5316\u6cbb\u7597\u6548\u679c\u548c\u9884\u540e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.1.4 Treg\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u52df\u96c6<\/p>\n<\/section>\n

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\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0cTreg\u7684\u62db\u52df\u662f\u4e00\u4e2a\u590d\u6742\u800c\u5173\u952e\u7684\u8fc7\u7a0b\u3002\u901a\u5e38\uff0cTregs\u88ab\u5438\u5f15\u5230\u80bf\u7624\u90e8\u4f4d\uff0c\u4ee5\u53c2\u4e0e\u8c03\u8282\u80bf\u7624\u5468\u56f4\u7684\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u4e00\u8fc7\u7a0b\u4e3b\u8981\u7531\u6076\u6027\u7ec6\u80de\u548c\u5148\u5929\u514d\u75ab\u7ec6\u80de\u5206\u6ccc\u7684\u8d8b\u5316\u56e0\u5b50\u9a71\u52a8\u3002\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u4e00\u4e9b\u5173\u952e\u7684\u8d8b\u5316\u56e0\u5b50-\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u901a\u8def\u8d77\u7740\u6838\u5fc3\u4f5c\u7528\uff0c\u5305\u62ecCCL17\/CCL22\u4e0e\u5176\u53d7\u4f53CCR4\uff0c\u4ee5\u53caCXCL12\u4e0e\u5176\u53d7\u4f53CXCR4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u76f8\u6bd4\u4e8e\u6e90\u81ea\u5916\u5468\u8840\u6216\u5065\u5eb7\u7ec4\u7ec7\u7684Treg\uff0c\u80bf\u7624\u6d78\u6da6\u6027\uff08TI\uff09Treg\u5728\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u8868\u73b0\u51fa\u66f4\u5f3a\u7684\u514d\u75ab\u6291\u5236\u529f\u80fd\u3002\u8fd9\u79cd\u589e\u5f3a\u7684\u6291\u5236\u80fd\u529b\u53ef\u80fd\u662f\u7531\u4e8e\u5b83\u4eec\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7279\u5b9a\u6fc0\u6d3b\u72b6\u6001\u3002\u5728\u8fd9\u79cd\u73af\u5883\u4e0b\uff0cTreg\u53ef\u80fd\u63a5\u53d7\u5230\u989d\u5916\u7684\u523a\u6fc0\u4fe1\u53f7\uff0c\u5982\u5c40\u90e8\u7ec6\u80de\u56e0\u5b50\u7684\u6d53\u5ea6\u53d8\u5316\u6216\u4e0e\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u8fdb\u4e00\u6b65\u5f3a\u5316\u4e86\u5b83\u4eec\u7684\u529f\u80fd\u5e76\u52a0\u5267\u4e86\u514d\u75ab\u6291\u5236\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u6b64\uff0c\u4e86\u89e3Treg\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u52df\u96c6\u548c\u529f\u80fd\u673a\u5236\u5bf9\u4e8e\u5f00\u53d1\u9488\u5bf9Treg\u7684\u65b0\u578b\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u8fd9\u4e0d\u4ec5\u53ef\u4ee5\u5e2e\u52a9\u6211\u4eec\u66f4\u597d\u5730\u63a7\u5236\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u673a\u5236\uff0c\u8fd8\u53ef\u80fd\u4e3a\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u65b0\u7684\u9776\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.1.5 \u9776\u5411Treg\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5<\/p>\n<\/section>\n

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\u7531\u4e8eTreg\u7ec6\u80de\u5728\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3001\u53d1\u5c55\u53ca\u514d\u75ab\u9003\u9038\u4e2d\u626e\u6f14\u5173\u952e\u89d2\u8272\uff0c\u5b83\u4eec\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u4e2d\u6f5c\u5728\u7684\u9776\u70b9\u3002\u9488\u5bf9Treg\u7684\u6cbb\u7597\u7b56\u7565\u4e3b\u8981\u96c6\u4e2d\u5728\u4e24\u5927\u65b9\u5411\uff1a\u8017\u7aedTreg\u4ee5\u53ca\u6291\u5236\u5176\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9996\u5148\uff0c\u4f7f\u7528\u9488\u5bf9CD25\u7684\u7279\u5f02\u6027\u6297\u4f53\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u9776\u5411Treg\u7684\u7b56\u7565\uff0c\u56e0\u4e3aCD25\u662fTreg\u8868\u9762\u7684\u4e3b\u8981\u6807\u8bb0\u7269\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u65b9\u6cd5\u7684\u5c40\u9650\u6027\u5728\u4e8e\uff0c\u6fc0\u6d3b\u7684CD4+ \u548cCD8+ T\u7ec6\u80de\u540c\u6837\u8868\u8fbeCD25\uff0c\u56e0\u6b64\u8fd9\u7c7b\u6cbb\u7597\u53ef\u80fd\u4f1a\u5f71\u54cd\u5230\u8fd9\u4e9b\u5177\u6709\u91cd\u8981\u514d\u75ab\u529f\u80fd\u7684\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e3a\u4e86\u66f4\u52a0\u7cbe\u786e\u5730\u9776\u5411Treg\u800c\u4e0d\u5f71\u54cd\u5176\u4ed6\u514d\u75ab\u7ec6\u80de\uff0c\u5f53\u524d\u7814\u7a76\u6b63\u5728\u63a2\u7d22\u65b0\u7684\u7597\u6cd5\u3002\u8fd9\u5305\u62ec\u5f00\u53d1\u65b0\u7684\u836f\u7269\uff0c\u4ee5\u7279\u5b9a\u5730\u6291\u5236Treg\u7684\u514d\u75ab\u6291\u5236\u6d3b\u6027\uff0c\u6216\u901a\u8fc7\u9776\u5411\u4e0eTreg\u8fc1\u79fb\u81f3\u80bf\u7624\u5fae\u73af\u5883\u76f8\u5173\u7684\u8d8b\u5316\u56e0\u5b50\u53ca\u5176\u53d7\u4f53\u9014\u5f84\u6765\u9650\u5236\u5176\u5728\u80bf\u7624\u4e2d\u7684\u96c6\u805a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u4e00\u4e9b\u539f\u672c\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6\u75be\u75c5\u7684\u836f\u7269\uff0c\u5982\u6297\u8840\u7ba1\u751f\u6210\u836f\u7269\u548c\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u4e5f\u6b63\u5728\u88ab\u7814\u7a76\u662f\u5426\u80fd\u6709\u6548\u6291\u5236Treg\u7684\u529f\u80fd\u3002\u8fd9\u4e9b\u836f\u7269\u7684\u91cd\u65b0\u8bc4\u4f30\u53ef\u80fd\u4e3a\u764c\u75c7\u6cbb\u7597\u5e26\u6765\u65b0\u7684\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u672c\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u8be6\u7ec6\u4ecb\u7ecd\u8fd9\u4e9b\u7b56\u7565\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5305\u62ec\u5728\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u548c\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u5e94\u7528\u60c5\u51b5\u3002\u8fd9\u4e9b\u4fe1\u606f\u5c06\u4e3a\u672a\u6765\u764c\u75c7\u6cbb\u7597\u63d0\u4f9b\u91cd\u8981\u7684\u79d1\u5b66\u57fa\u7840\u548c\u4e34\u5e8a\u6307\u5bfc\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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29.2 \u5c0f\u5242\u91cf\u5316\u7597\u6240\u81f4\u7684Treg\u8017\u7aed<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd1\u5e74\u6765\uff0c\u4f20\u7edf\u7684\u89c2\u5ff5\u8ba4\u4e3a\u6297\u764c\u5316\u7597\u4e3b\u8981\u901a\u8fc7\u76f4\u63a5\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u6765\u53d1\u6325\u4f5c\u7528\uff0c\u5e76\u901a\u5e38\u4f1a\u6291\u5236\u514d\u75ab\u7cfb\u7edf\u3002\u7136\u800c\uff0c\u65b0\u7684\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u67d0\u4e9b\u5316\u7597\u836f\u7269\u4e5f\u80fd\u591f\u5f15\u53d1\u514d\u75ab\u4ecb\u5bfc\u7684\u6297\u764c\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u81ea21\u4e16\u7eaa\u521d\u4ee5\u6765\uff0c\u73af\u78f7\u9170\u80fa\uff08CTX\uff09\u3001\u7d2b\u6749\u9187\uff08PTX\uff09\u548c\u6c1f\u8fbe\u62c9\u6ee8\uff08FDB\uff09\u7b49\u5e38\u89c4\u5316\u7597\u836f\u7269\u5f00\u59cb\u88ab\u7528\u4e8e\u665a\u671f\u8010\u836f\u764c\u75c7\u60a3\u8005\u7684\u4f4e\u5242\u91cf\u957f\u671f\u7ed9\u836f\u8ba1\u5212\u4e2d\u3002\u8fd9\u79cd\u6240\u8c13\u7684\u8282\u5f8b\u5316\u7597\u65e8\u5728\u901a\u8fc7\u6700\u5c0f\u7684\u6bd2\u526f\u4f5c\u7528\u51cf\u5c11\u80bf\u7624\u8840\u7ba1\u751f\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fd9\u4e00\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u8868\u660e\u8fd9\u4e9b\u5316\u7597\u836f\u7269\u80fd\u591f\u8017\u7aed\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u53ca\u5916\u5468\u8840\u4e2d\u7684\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\uff0c\u4ece\u800c\u635f\u5bb3\u8fd9\u4e9b\u514d\u75ab\u6291\u5236\u7ec6\u80de\u7684\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u8282\u5f8b\u5316\u7597\u4e0d\u4ec5\u6709\u52a9\u4e8e\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u8fd8\u80fd\u6062\u590d\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u7684\u6297\u80bf\u7624\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Fig <\/span>29.1<\/span>  <\/span>\u63cf\u8ff0\u4e86\u5c0f\u5242\u91cf\u5316\u7597\u548cIL-2\/IL-2R\u9776\u5411\u836f\u7269\u5982\u4f55\u4ecb\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u8017\u7aed\uff1a<\/span>(A) \u5c0f\u5242\u91cf\u53e3\u670d\u8282\u5f8b\u5316\u7597\uff1a\u4f7f\u7528\u73af\u78f7\u9170\u80fa\uff08CTX\uff09\u3001\u7d2b\u6749\u9187\uff08PTX\uff09\u548c\u6c1f\u8fbe\u62c9\u6ee8\uff08FDB\uff09\u7b49\u836f\u7269\uff0c\u5728\u5468\u671f\u6027\u4f4e\u5242\u91cf\u7ed9\u836f\u7684\u65b9\u6848\u4e2d\uff0c\u53ef\u4ee5\u663e\u8457\u964d\u4f4eTreg\u7684\u6570\u91cf\u3002\u8fd9\u79cd\u7b56\u7565\u6700\u5c0f\u5316\u4e86\u6bd2\u526f\u4f5c\u7528\uff0c\u540c\u65f6\u6709\u6548\u5730\u6291\u5236\u4e86Treg\u7684\u514d\u75ab\u8c03\u8282\u529f\u80fd\uff0c\u4fc3\u8fdb\u4e86\u514d\u75ab\u7cfb\u7edf\u5bf9\u80bf\u7624\u7684\u653b\u51fb\u3002<\/span>(B) IL-2\/IL-2\u53d7\u4f53\u963b\u65ad\u5242\uff1a\u6297CD25\u6297\u4f53Daclizumab\u548cBasiliximab\u901a\u8fc7\u4ecb\u5bfc\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\u6216\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08CDC\uff09\u673a\u5236\uff0c\u80fd\u591f\u5f15\u53d1Treg\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u4e24\u79cd\u57fa\u4e8eCD25\u7684\u514d\u75ab\u6bd2\u7d20\u6297\u4f53\u6b63\u5728\u4eba\u7c7b\u764c\u75c7\u6cbb\u7597\u4e2d\u8fdb\u884c\u6d4b\u8bd5\uff1aIMITOX-25\uff08RFT5-DGA\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u5c06\u8131\u7cd6\u5316\u84d6\u9ebb\u6bd2\u7d20A\u4e0eCD25\u6297\u4f53RFT5\u76f8\u8fde\u7684\u836f\u7269\uff1b\u4ee5\u53caLMB-2\uff0c\u4e00\u4e2a\u5c06CD25\u6297\u4f53\u7684Fv\u90e8\u5206\u4e0e\u5047\u5355\u80de\u83cc\u5916\u6bd2\u7d20A\u7247\u6bb5\u7ed3\u5408\u7684\u878d\u5408\u86cb\u767d\u3002\u53e6\u4e00\u836f\u7269\uff0cDenileukin diftitox\uff08Ontak\uff09\uff0c\u56e0\u542b\u6709IL-2\u6210\u5206\uff0c\u80fd\u591f\u4e0e\u9ad8\u4eb2\u548c\u529b\u7684IL-2\u53d7\u4f53\uff08CD25\uff09\u7ed3\u5408\uff0c\u4fc3\u4f7fTreg\u7684\u5feb\u901f\u5185\u541e\u548c\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Ghiringhelli\u53ca\u5176\u540c\u4e8b\u9996\u6b21\u8bc1\u660e\uff0c\u4e0e\u672a\u7ecf\u6cbb\u7597\u7684\u52a8\u7269\u76f8\u6bd4\uff0c\u5355\u5242\u91cf\u7684\u73af\u78f7\u9170\u80fa\uff08CTX\uff09\u80fd\u663e\u8457\u8017\u7aed\u8377\u7624\u5927\u9f20\u4f53\u5185\u7684Tregs\u3002\u8fd9\u4e00\u53d1\u73b0\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5f97\u5230\u8fdb\u4e00\u6b65\u8bc1\u5b9e\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\u5916\u5468\u8840\u4e2d\u7684\u514d\u75ab\u6291\u5236Tregs\u6570\u91cf\u7684\u9009\u62e9\u6027\u6025\u5267\u51cf\u5c11\uff0c\u6709\u52a9\u4e8e\u6539\u5584\u80bf\u7624\u7684\u53d1\u751f\u548c\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u8fd9\u4e9b\u7814\u7a76\u5c06\u8282\u5f8b\u5316\u7597\u6cd5\uff0c\u7279\u522b\u662f\u4f7f\u7528CTX\uff0c\u5728\u6297\u764c\u514d\u75ab\u6cbb\u7597\u524d\uff0c\u4f5c\u4e3a\u964d\u4f4e\u80bf\u7624\u8bf1\u5bfc\u7684\u514d\u75ab\u8010\u53d7\u6027\u7684\u6709\u6548\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u5bf9\u96be\u6cbb\u6027\u548c\u8f6c\u79fb\u6027\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u8fdb\u884c\u7684\u7814\u7a76\u4e2d\uff0c\u845b\u82f1\u5b50\u7b49\u4eba\u76d1\u6d4b\u4e86\u6bcf\u592950\u6beb\u514b\u53e3\u670dCTX\uff08\u4e3a\u671f\u4e09\u4e2a\u6708\uff09\u5bf9\u5faa\u73af\u4e2dTreg\u6570\u91cf\u548c\u529f\u80fd\u7684\u5f71\u54cd\uff0c\u4ee5\u53ca\u5176\u5bf9\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u514d\u75ab\u5b66\u6548\u5e94\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u4e73\u817a\u764c\u60a3\u8005\u4e2dTreg\u7684\u77ed\u6682\u8017\u7aed\u4e0eT\u7ec6\u80de\u7684\u6d3b\u6027\u589e\u5f3a\u76f8\u5173\uff0c\u5e76\u4e0e\u826f\u597d\u7684\u4e34\u5e8a\u7ed3\u679c\u6709\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8bb8\u591a\u5c0f\u9f20\u548c\u4eba\u7c7b\u764c\u75c7\u7814\u7a76\u4e2d\uff0c\u75ab\u82d7\u63a5\u79cd\u524d\u901a\u8fc7\u4f4e\u5242\u91cf\u5316\u7597\u8017\u7aedTreg\u663e\u8457\u63d0\u9ad8\u4e86\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\uff0c\u5e76\u8bf1\u53d1\u4e86\u6709\u6548\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u9879\u9488\u5bf9\u80be\u764c\u7684\u968f\u673aII\u671f\u7814\u7a76\u4e2d\uff0c\u5355\u5242\u91cfCTX\u7684\u4f7f\u7528\u964d\u4f4e\u4e86Tregs\u7684\u6570\u91cf\u5e76\u8bf1\u5bfc\u4e86\u7279\u5f02\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u8fd9\u4e0e\u8f83\u957f\u7684\u751f\u5b58\u671f\u76f8\u5173\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7136\u800c\uff0c\u4e0d\u662f\u6240\u6709\u7814\u7a76\u90fd\u62a5\u544a\u4e86\u6b63\u9762\u7ed3\u679c\u3002\u5728\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u524d\u5217\u817a\u764c\uff08MCRPC\uff09\u60a3\u8005\u63a5\u53d7\u4e86DC\u75ab\u82d7\u548c\u957f\u671f\u7684\u5316\u7597\u836f\u7269\uff08\u8282\u5f8b\u5316\u73af\u78f7\u9170\u80fa\u3001\u591a\u897f\u7d2b\u6749\u9187\u548c\u6cfc\u5c3c\u677e\uff09\u6cbb\u7597\u3002\u867d\u7136\u89c2\u5bdf\u5230\u5916\u5468\u8840\u4e2dTregs\u663e\u8457\u4e0b\u964d\uff0c\u4f46\u76ee\u524d\u8fd8\u6ca1\u6709\u8bc1\u636e\u663e\u793a\u8fd9\u4e0e\u8f83\u597d\u7684\u751f\u5b58\u671f\u6709\u663e\u8457\u5173\u8054\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c49\u540d\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\uff08\u5305\u62ec\u4e73\u817a\u764c\u3001\u80ba\u764c\u3001\u80be\u764c\u3001\u80c3\u764c\u3001\u8180\u80f1\u764c\u548c\u524d\u5217\u817a\u764c\uff09\u63a5\u53d7\u4e86BCG\u548cCTX\u7684\u8054\u5408\u6cbb\u7597\u540e\uff0c\u5916\u5468Tregs\u6570\u91cf\u610f\u5916\u5730\u589e\u52a0\u3002\u8fd9\u79cd\u4e0e\u9884\u671f\u76f8\u53cd\u7684\u7ed3\u679c\u53ef\u80fd\u4e0e\u7ed9\u836f\u65b9\u5f0f\u7684\u4e0d\u540c\u6709\u5173\uff0c\u4f8b\u5982\u5728\u6b64\u7814\u7a76\u4e2dCTX\u662f\u9759\u8109\u6ef4\u6ce8\u7ed9\u836f\uff0c\u800c\u5176\u4ed6\u7814\u7a76\u4e2d\u901a\u5e38\u662f\u53e3\u670d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0cKoumarianou\u53ca\u5176\u540c\u4e8b\u7684\u7814\u7a76\u8868\u660e\uff0c\u5373\u4f7f\u662f\u53e3\u670d\u7684\u8282\u5f8b\u5316\u7597\u836f\u7269\u4e5f\u80fd\u8bf1\u5bfcTreg\u6570\u91cf\u589e\u52a0\u548c\u514d\u75ab\u6d3b\u6027\u7684\u6291\u5236\uff0c\u8fd9\u4e9b\u5f71\u54cd\u5728\u8282\u5f8b\u5316\u7597\u4e2d\u6bd4\u5728\u6807\u51c6\u5316\u7597\u4e2d\u66f4\u4e3a\u663e\u8457\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0cKoumarianou\u53ca\u5176\u540c\u4e8b\u7684\u7814\u7a76\u8868\u660e\uff0c\u5373\u4f7f\u662f\u53e3\u670d\u7684\u8282\u5f8b\u5316\u7597\u836f\u7269\u4e5f\u80fd\u8bf1\u5bfcTreg\u6570\u91cf\u589e\u52a0\u548c\u514d\u75ab\u6d3b\u6027\u7684\u6291\u5236\uff0c\u8fd9\u4e9b\u5f71\u54cd\u5728\u8282\u5f8b\u5316\u7597\u4e2d\u6bd4\u5728\u6807\u51c6\u5316\u7597\u4e2d\u66f4\u4e3a\u663e\u8457\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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29.3  IL-2\u53d7\u4f53(IL-2R)\u8bf1\u5bfc\u7684Treg\u8017\u7aed<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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T\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7279\u5f81\u6027\u8868\u8fbe\u9ad8\u4eb2\u548c\u529b\u7684IL-2\u53d7\u4f53\u03b1\u94fe\uff08CD25\uff09\u3002\u8fd9\u4e9b\u9ad8\u4eb2\u548c\u529b\u7684IL-2\u53d7\u4f53\u4f7fTreg\u80fd\u591f\u6355\u83b7\u73af\u5883\u4e2d\u7684IL-2\uff0c\u9650\u5236\u4f20\u7edfT\u7ec6\u80de\uff08Tconv\uff09\u7684\u53ef\u7528IL-2\uff0c\u4ece\u800c\u963b\u788d\u5b83\u4eec\u7684\u6269\u5f20\u548c\u6d3b\u5316\u3002\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\uff0c\u5229\u7528IL-2\/IL-2R\u8f74\u6765\u8017\u7aedTreg\uff0c\u6709\u52a9\u4e8e\u6062\u590d\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.3.1 \u6297CD25\u6297\u4f53\u6cbb\u7597(\u5982\u8fbe\u5229\u73e0\u5355\u6297\u548c\u5df4\u5229\u6614\u5355\u6297)<\/p>\n<\/section>\n

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Daclizumab\u662f\u4e00\u79cd\u4eba\u6e90\u5316\u7684\u9488\u5bf9\u4ebaCD25 IgG1-\u03ba\u7684\u5355\u6297\u3002\u7ed9\u836f\u65f6\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0d\u4f1a\u5f15\u8d77\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002\u5b83\u6700\u521d\u4e8e1997\u5e74\u88ab\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40(FDA)\u6279\u51c6\u7528\u4e8e\u9884\u9632\u80be\u79fb\u690d\u6392\u65a5\u53cd\u5e94\uff0c\u73b0\u5728\u5728\u51e0\u4e2a\u764c\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7528\u4e8e\u8fdb\u884cTregs\u8017\u7aed\u6d4b\u8bd5(Fig 29.1b<\/span>)(Table 29.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7b2c\u4e00\u7ec4\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u63a2\u8ba8\u4e86\u5728\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u63a5\u53d7DC\u75ab\u82d7\u63a5\u79cd\u524d\uff0cDaclizumab\u7528\u4e8e\u8017\u7aed\u764c\u75c7Treg\u7684\u6548\u679c\u3002\u7814\u7a76\u4f7f\u7528\u4e86Daclizumab\u7684\u5355\u4e00\u4f4e\u5242\u91cf\uff080.5 mg\/kg\uff09\uff0c\u53d1\u73b0\u8be5\u836f\u7269\u80fd\u6709\u6548\u8017\u5c3d\u60a3\u8005\u5916\u5468\u8840\u4e2d\u8868\u8fbeCD4+<\/sup>\u3001\u9ad8\u8868\u8fbeCD25\u548cFoxP3\u7684T\u7ec6\u80de\u3002\u7136\u800c\uff0c\u7ea630\u5929\u540e\uff0c\u968f\u7740Daclizumab\u7684\u6e05\u9664\uff0c\u89c2\u5bdf\u5230Tregs\u7684\u518d\u6b21\u51fa\u73b0\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u63a5\u53d7Daclizumab\u9884\u5904\u7406\u7684\u60a3\u8005\u76f8\u8f83\u4e8e\u4ec5\u63a5\u79cd\u75ab\u82d7\u7684\u60a3\u8005\uff0c\u5176\u75ab\u82d7\u8bf1\u5bfc\u7684\u6548\u5e94\u6027T\u7ec6\u80de\u7279\u5f02\u6027\u53cd\u5e94\u6548\u679c\u8f83\u5dee\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u53e6\u4e00\u9879\u5173\u4e8e\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u8bd5\u9a8c\u4e2d\uff0cRech\u7b49\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86Daclizumab\u4e0e\u591a\u80bd\u75ab\u82d7\u8054\u5408\u4f7f\u7528\u7684\u7597\u6548\u3002\u7ed3\u679c\u8868\u660e\uff0cDaclizumab\u80fd\u663e\u8457\u5e76\u6301\u7eed\u5730\u8017\u5c3d\u5916\u5468\u8840\u4e2d\u7684Tregs\uff0c\u5e76\u6709\u6548\u589e\u5f3a\u4e86\u75ab\u82d7\u8bf1\u5bfc\u7684\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u3002\u8fd9\u4e9b\u53d1\u73b0\u5f3a\u8c03\u4e86\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\uff0c\u901a\u8fc7\u9776\u5411Treg\u6765\u8c03\u8282\u514d\u75ab\u54cd\u5e94\u7684\u6f5c\u529b\uff0c\u5c3d\u7ba1\u5176\u6548\u679c\u53ef\u80fd\u53d7\u591a\u79cd\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u6297CD25\u5355\u514b\u9686\u6297\u4f53Daclizumab\u80fd\u6709\u6548\u8bf1\u5bfc\u764c\u75c7\u60a3\u8005\u4e2dTreg\u7684\u8017\u7aed\u3002Treg\u7684\u51cf\u5c11\u53ef\u80fd\u5bfc\u81f4\u4f53\u5185\u8868\u8fbeCD25\u7684T\u7ec6\u80de\u88ab\u6fc0\u6d3b\uff0c\u800c\u5269\u4f59\u5728\u4f53\u5185\u7684Daclizumab\u6297\u4f53\u53ef\u80fd\u5bf9\u8fd9\u4e9b\u65b0\u6fc0\u6d3b\u7684CD25+ T\u7ec6\u80de\u4ea7\u751f\u4e0d\u5229\u5f71\u54cd\u3002\u5b9e\u9645\u4e0a\uff0cDaclizumab\u7684\u534a\u8870\u671f\u8d85\u8fc7\u56db\u5468\uff0c\u8fd9\u53ef\u80fd\u89e3\u91ca\u4e86Jacobs\u7b49\u4eba\u89c2\u5bdf\u5230\u63a5\u79cd\u75ab\u82d7\u540e\u60a3\u8005T\u7ec6\u80de\u7279\u5f02\u6027\u53cd\u5e94\u8f83\u4f4e\u7684\u73b0\u8c61\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u79cd\u6297CD25\u5355\u514b\u9686\u6297\u4f53\uff0c\u5d4c\u5408\u6297\u4f53Basiliximab\uff0c\u4e5f\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u8bc4\u4f30\u5176\u5bf9Treg\u7684\u8017\u7aed\u6548\u679c(Fig 29.1b<\/span>)\u3002Basiliximab\u76ee\u524d\u6b63\u5728\u9488\u5bf9\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u3001\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u591a\u4e2aI\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u6d4b\u8bd5\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u65e8\u5728\u63a2\u7d22Basiliximab\u5728\u4e0d\u540c\u7c7b\u578b\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u6548\u7528\u548c\u5b89\u5168\u6027(Table 29.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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<\/p>\n<\/section>\n<\/section>\n

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Table 29.1<\/span><\/span> CD25-\u764c\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u9776\u5411\u836f\u7269<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.3.2 Denileukin Diftitox (ONTAK\u00ae)
<\/p>\n<\/section>\n

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Denileukin diftitox\uff08DD\uff09\/Ontak \u662f\u4e00\u79cd\u7531\u767d\u5589\u6bd2\u7d20\u7684\u7ed3\u6784\u57df\u548cIL-2\u6784\u6210\u7684\u57fa\u56e0\u5de5\u7a0b\u91cd\u7ec4\u878d\u5408\u86cb\u767d\u3002\u8fd9\u79cd\u86cb\u767d\u8d28\u5305\u542bIL-2\u6210\u5206\uff0c\u4f7f\u5176\u80fd\u591f\u4e0e\u9ad8\u4eb2\u548c\u529b\u7684IL-2\u53d7\u4f53\uff08IL-2R\uff09\u7ed3\u5408\uff0c\u4fc3\u4f7f\u7ec6\u80de\u8fc5\u901f\u5185\u541e\u5e76\u572840-72\u5c0f\u65f6\u5185\u5f15\u53d1\u7ec6\u80de\u51cb\u4ea1(Fig 29.1b<\/span>)\u3002\u81ea1999\u5e74\u8d77\uff0cOntak\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u8868\u8fbeIL-2R\u03b1\u94feCD25\u7684\u6301\u7eed\u6027\u6216\u590d\u53d1\u6027\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u3002\u81ea\u90a3\u65f6\u8d77\uff0cOntak\u4e5f\u88ab\u7528\u4e8e\u9776\u5411\u8868\u8fbeCD25\u7684Treg\u7ec6\u80de\u7684\u764c\u75c7\u6cbb\u7597\uff0c\u4ee5\u8017\u5c3dCD25+<\/sup>\u7ec6\u80de\u7fa4\u3002\u5230\u76ee\u524d\u4e3a\u6b62\uff0cOntak\u5df2\u7ecf\u7528\u4e8e\u6cbb\u7597\u4e0d\u540c\u764c\u75c7\u3001\u4e0d\u540c\u5242\u91cf\u548c\u4e0d\u540c\u65b9\u6848\u7684Treg\u8017\u7aed\u7684\u8bb8\u591a\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7ed3\u679c\u5404\u4e0d\u76f8\u540c(Table 29.2<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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Table 29.2<\/span><\/span> \u764c\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684Ontak(\u4ee3\u5c3c\u7f57\u91d1\u5730\u592b\u59a5)<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Ontak\u5df2\u7ecf\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u88ab\u7528\u4e8e\u6cbb\u7597\u4e0d\u540c\u7684\u764c\u75c7\u7c7b\u578b\uff0c\u8bd5\u9a8c\u4e2d\u91c7\u7528\u4e86\u4e0d\u540c\u7684\u5242\u91cf\u548c\u6cbb\u7597\u65b9\u6848\uff0c\u7ed3\u679c\u8868\u73b0\u5404\u5f02\u3002\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\uff0cOntak\u901a\u5e38\u4ee5\u5355\u524218\u03bcg\/kg\u7684\u5242\u91cf\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u6216\u591a\u80bd\u75ab\u82d7\u8054\u5408\u4f7f\u7528\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u6db5\u76d6\u4e86\u6cbb\u7597\u764c\u80da\u6297\u539f\uff08CEA\uff09\u9633\u6027\u7684\u6076\u6027\u80bf\u7624\u3001\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u548c\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002\u5728\u8fd9\u4e09\u9879\u7814\u7a76\u4e2d\uff0c\u6709\u4e24\u9879\u62a5\u544a\u6307\u51fa\u5728\u4f7f\u7528\u8be5\u5242\u91cf\u65f6CD4+<\/sup>CD25+<\/sup>FoxP3+ <\/sup>T\u7ec6\u80de\u7684\u6570\u91cf\u672a\u53d1\u751f\u53d8\u5316\u3002\u7136\u800c\uff0c\u5728\u80be\u764c\u7684\u8bd5\u9a8c\u4e2d\uff0c\u89c2\u5bdf\u5230\u9ad8\u8868\u8fbeCD4+<\/sup>\u548cCD25\u7684Treg\u6682\u65f6\u8017\u5c3d\uff0c\u4f46\u5bf9\u4f4e\u8868\u8fbeCD25\u7684T\u7ec6\u80de\u548c\u5176\u4ed6\u7ec6\u80de\u7fa4\u6ca1\u6709\u663e\u8457\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u9488\u5bf9\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u4f7f\u7528Ontak\u8fdb\u884cTreg\u8017\u7aed\u7684\u51e0\u9879\u8bd5\u9a8c\u4e2d\uff0c\u6709\u56db\u9879\u7814\u7a76\u5df2\u88ab\u53d1\u8868\u3002\u8fd9\u4e9b\u7814\u7a76\u663e\u793a\uff0cOntak\u5728\u4e00\u5b9a\u6761\u4ef6\u4e0b\u53ef\u4ee5\u6709\u6548\u8017\u7aedTreg\u3002\u5177\u4f53\u5730\uff0c\u5f53\u4ee512\u03bcg\/kg\/d\u7684\u5242\u91cf\u8fde\u7eed\u7ed9\u836f4\u5929\uff0c\u6216\u4ee55\u548c18\u03bcg\/kg\/d\u7684\u5242\u91cf\u8fde\u7eed\u7ed9\u836f3\u5929\u65f6\uff0cOntak\u80fd\u591f\u77ac\u65f6\u8017\u7aedTreg\u3002\u7136\u800c\uff0c\u4ee5\u5355\u6b21\u6ce8\u5c0418\u03bcg\/kg\u7684\u5242\u91cf\u6216\u8fde\u7eed5\u5929\u7ed9\u836f9\u548c18\u03bcg\/kg\u65f6\uff0c\u6548\u679c\u4e0d\u4f73\u3002\u8fd9\u8868\u660e\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u548c\u5176\u4ed6\u7c7b\u578b\u7684\u764c\u75c7\u6cbb\u7597\u4e2d\uff0c\u9009\u62e9\u5408\u9002\u7684Ontak\u5242\u91cf\u5bf9\u6709\u6548\u8017\u7aedTreg\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1\u5728\u4e00\u4e9b\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u4e86Treg\u7ec6\u80de\u7684\u8017\u7aed\uff0c\u4f46Ontak\u7684\u4e34\u5e8a\u6548\u679c\u5e76\u4e0d\u603b\u662f\u5982\u9884\u671f\u90a3\u6837\u663e\u8457\uff0c\u6709\u65f6\u751a\u81f3\u65e0\u660e\u663e\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u5f15\u53d1\u4e86\u5173\u4e8eOntak\u53ef\u80fd\u5bf9\u60a3\u8005\u514d\u75ab\u7cfb\u7edf\u6709\u5176\u4ed6\u672a\u88ab\u53d1\u73b0\u7684\u4e0d\u826f\u5f71\u54cd\u7684\u62c5\u5fe7\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u9879\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u4f7f\u7528Ontak\u9884\u5904\u7406\u6765\u8017\u7aedTregs\uff0c\u968f\u540e\u63a5\u79cdDC\u75ab\u82d7\u3002\u7ed3\u679c\u663e\u793a\uff0cOntak\u9884\u5904\u7406\u672a\u80fd\u6709\u6548\u8bf1\u5bfc\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684CD4+<\/sup>\u548cCD8+ <\/sup>T\u7ec6\u80de\u53cd\u5e94\uff0c\u4ece\u800c\u672a\u8fbe\u5230\u9884\u671f\u7684\u4e34\u5e8a\u7597\u6548\u3002\u7814\u7a76\u8fd8\u53d1\u73b0\uff0cOntak\u7684\u4f5c\u7528\u53ef\u80fd\u8d85\u51fa\u5355\u7eaf\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u8017\u7aed\uff0c\u5b83\u8fd8\u53ef\u80fd\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u5927\u7684\u514d\u75ab\u8c03\u8282\u5242\uff0c\u5bfc\u81f4\u751f\u6210\u8010\u53d7\u6027DC\u7ec6\u80de\u3002\u6b64\u5916\uff0cOntak\u672a\u80fd\u6709\u6548\u8bf1\u5bfcTreg\u7684\u51cb\u4ea1\uff0c\u4e5f\u672a\u63d0\u9ad8\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6700\u8fd1\uff0c\u8fd8\u542f\u52a8\u4e86\u4e00\u9879\u7b2c\u4e09\u9636\u6bb5\u8bd5\u9a8c\uff0c\u76ee\u7684\u662f\u8bc4\u4f30\u6539\u8fdb\u7eaf\u5ea6\u7684Ontak\uff08E7777\uff09\u6cbb\u7597\u6301\u7eed\u6027\u6216\u590d\u53d1\u6027\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CTCL\uff09\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u8bd5\u9a8c\u7f16\u53f7\u4e3aNCT01871727\u3002\u8fd9\u9879\u8bd5\u9a8c\u65e8\u5728\u8fdb\u4e00\u6b65\u9a8c\u8bc1E7777\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u7684\u6f5c\u529b\u548c\u6539\u8fdb\u7684\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

29.3.3  \u6297CD25\u514d\u75ab\u6bd2\u7d20\u6297\u4f53<\/p>\n<\/section>\n

\n
\n
\n

\u5728\u9776\u5411CD25\u7684\u514d\u75ab\u6bd2\u7d20\u6297\u4f53\u9886\u57df\uff0c\u5b58\u5728\u4e24\u79cd\u4e3b\u8981\u7684\u7597\u6cd5\uff1aIMITOX-25\uff08RFT5-DGA\uff09\u548cLMB-2\u3002IMITOX-25\u662f\u4e00\u79cd\u5c06\u8131\u7cd6\u57fa\u5316\u84d6\u9ebb\u6bd2\u7d20A\u4e0eCD25\u6297\u4f53RFT5\u7ed3\u5408\u7684\u4ea7\u54c1\uff0c\u8be5\u878d\u5408\u86cb\u767d\u5728\u7ec6\u80de\u5185\u5316\u540e\u901a\u8fc7\u6291\u5236\u86cb\u767d\u8d28\u5408\u6210\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u3002\u800cLMB-2\u5219\u662f\u4e00\u79cd\u5c06CD25\u6297\u4f53\u7684Fv\u7247\u6bb5\u4e0e\u5047\u5355\u80de\u83cc\u5916\u6bd2\u7d20A\u7247\u6bb5\u7ed3\u5408\u7684\u878d\u5408\u86cb\u767d\uff0c\u5df2\u77e5\u80fd\u591f\u8bf1\u5bfccaspase\u4ecb\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1(Fig 29.1b<\/span>)\u3002<\/strong>\u8fd9\u4e9b\u514d\u75ab\u6bd2\u7d20\u80fd\u591f\u5728\u4f53\u5185\u8fc5\u901f\uff08\u5c11\u4e8e4\u5c0f\u65f6\uff09\u6e05\u9664\u6297CD25\u6297\u4f53\uff0c\u5e76\u5df2\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30(Table 29.1<\/span>)\u3002\u7136\u800c\uff0c\u5c3d\u7ba1CD25+<\/sup> Treg\u7ec6\u80de\u53ef\u88ab\u77ed\u6682\u8017\u5c3d\uff0cCD25\u2212 <\/sup>Treg\u4e9a\u7fa4\u5374\u5f97\u4ee5\u5b58\u6d3b\uff0c\u5bfc\u81f4\u4ec5\u8017\u5c3dCD25+ <\/sup>Treg\u7ec6\u80de\u5e76\u4e0d\u8db3\u4ee5\u663e\u8457\u589e\u5f3a\u5bf9\u591a\u80bd\u75ab\u82d7\u7684\u514d\u75ab\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

\u7efc\u5408\u8003\u8651\uff0cDaclizumab\u3001Ontak\u4ee5\u53ca\u5176\u4ed6CD25+\u7ec6\u80de\u8017\u5c3d\u5242\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u5df2\u663e\u793a\u51fa\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u8017\u5c3dCD25+ <\/sup>Tregs\u7684\u6f5c\u529b\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7597\u6cd5\u7684\u6548\u679c\u6709\u65f6\u53d7\u9650\u4e8eCD25\u5e76\u975e\u53ea\u7531Tregs\u7279\u6709\u8868\u8fbe\u8fd9\u4e00\u4e8b\u5b9e\u3002\u5728\u4e00\u4e9b\u8bd5\u9a8c\u4e2d\uff0c\u8fd9\u4e9b\u7597\u6cd5\u672a\u80fd\u589e\u5f3a\u75ab\u82d7\u8bf1\u5bfc\u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u53ef\u80fd\u4e0e\u6b64\u76f8\u5173\u3002\u6b64\u5916\uff0cCD25+ <\/sup>Treg\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\u7684\u6301\u7eed\u5b58\u5728\u63d0\u793a\u6211\u4eec\uff0c\u5f00\u53d1\u66f4\u5177Treg\u7279\u5f02\u6027\u7684\u6cbb\u7597\u7b56\u7565\u6216\u5c06\u8fd9\u4e9b\u7597\u6cd5\u4e0e\u5176\u4ed6Treg\u8017\u5c3d\u836f\u7269\u7ed3\u5408\u4f7f\u7528\uff0c\u53ef\u80fd\u4f1a\u63d0\u4f9b\u66f4\u52a0\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.3.4  \u65b0\u5174\u7684\u6297CD25\u6297\u4f53\u7597\u6cd5<\/p>\n<\/section>\n

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\n
\n

\u53e6\u4e00\u4e2a\u5173\u4e8e\u9488\u5bf9CD25\u7684\u6cbb\u7597\u7b56\u7565\u7684\u7f3a\u9677\u662f\uff0c\u5168\u8eab\u6027\u8017\u5c3dTregs\u53ef\u80fd\u7834\u574f\u5916\u5468\u7684\u514d\u75ab\u5e73\u8861\uff0c\u5e76\u5bfc\u81f4\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002\u4e3a\u6b64\uff0c\u4e00\u79cd\u4ee4\u4eba\u5174\u594b\u7684\u65b0\u4e00\u4ee3\u6297CD25\u6297\u4f53\u5df2\u88ab\u5f00\u53d1\uff0c\u80fd\u591f\u9009\u62e9\u6027\u5730\u8017\u5c3d\u80bf\u7624\u5185\u7684Treg\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
\n

\u8fd1\u671f\uff0c\u4f50\u85e4\u7b49\u4eba\u5f00\u53d1\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u65b9\u6cd5\uff0c\u4ed6\u4eec\u5c06\u6297CD25 F(ab\u2018)2\u7247\u6bb5\u4e0e\u5149\u6fc0\u6d3b\u7845\u915e\u83c1\u67d3\u6599\uff08IRDye 700DX\uff09\u7ed3\u5408\u3002\u8fd9\u79cd\u7ed3\u5408\u7269\u88ab\u8bbe\u8ba1\u7528\u4e8e\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\u9009\u62e9\u6027\u5730\u6d88\u8017\u80bf\u7624\u5185\uff08TI\uff09Tregs\u3002\u901a\u8fc7\u6ce8\u5c04\u8fd9\u79cd\u5149\u6d3b\u5316\u6297\u4f53\u540e\uff0c\u5c06\u80bf\u7624\u5c40\u90e8\u66b4\u9732\u4e8e\u8fd1\u7ea2\u5916\u5149\uff0c\u6fc0\u6d3bIRDye 700DX\uff0c\u4ece\u800c\u5b9e\u73b0\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u5185\u7684Tregs\u8017\u5c3d\uff0c\u800c\u4e0d\u5f71\u54cd\u5468\u56f4\u7ec6\u80de\u6216\u7cfb\u7edf\u4e2d\u672a\u66b4\u9732\u4e8e\u8fd1\u7ea2\u5916\u5149\u7684CD25+ <\/sup>Tregs\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u80bf\u7624\u90e8\u4f4d\u768485% CD4+<\/sup>CD25+ <\/sup>Tregs\u572830\u5206\u949f\u5185\u88ab\u8017\u5c3d\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u89c2\u5bdf\u5230\uff0c\u8fd1\u7ea2\u5916\u6cbb\u7597\u540e\uff0cCD8+ T\u7ec6\u80de\u3001NK\u7ec6\u80de\u4ee5\u53ca\u6297\u539f\u63d0\u5448\u7ec6\u80de\u8fc5\u901f\u6fc0\u6d3b\u3002\u8fd9\u79cd\u9488\u5bf9\u5c40\u90e8Treg\u7684\u8017\u5c3d\u7b56\u7565\u4e0d\u4ec5\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u6d88\u9000\uff0c\u8fd8\u663e\u8457\u5ef6\u957f\u4e86\u5c0f\u9f20\u5728\u4ec5\u4e00\u6b21\u6cbb\u7597\u540e\u7684\u5b58\u6d3b\u65f6\u95f4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u6b64\u5916\uff0c\u5df2\u7ecf\u6709FDA\u6279\u51c6\u4f7f\u7528\u7684\u4eba\u6e90\u5316CD25\u6297\u4f53\uff0c\u5982daclizumab\u548cbasiliximab\uff0c\u51cf\u5c11\u4e86\u5c06\u8fd9\u79cd\u65b0\u7597\u6cd5\u8f6c\u5316\u4e3a\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u969c\u788d\u3002\u5e76\u4e14\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u4e0eIRDye 700DX\u7ed3\u5408\u7684\u6297\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u7684I\u671f\u4eba\u4f53\u7814\u7a76\uff0c\u9488\u5bf9\u65e0\u6cd5\u624b\u672f\u7684\u5934\u9888\u764c\u60a3\u8005\uff08NCT02422679\uff09\u3002\u8fd9\u4e9b\u8fdb\u5c55\u4f7f\u5f97\u8fd1\u7ea2\u5916\u5149\u514d\u75ab\u7597\u6cd5\u7b56\u7565\u6709\u671b\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e3a\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u6cbb\u7597\u65b0\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n
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<\/p>\n<\/section>\n<\/section>\n

\n
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29.4  \u5e72\u6270Treg\u7ec6\u80de\u5411\u80bf\u7624\u7684\u8fc1\u79fb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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29.4.1  CCL22-CCR4\u901a\u8def\u963b\u65ad<\/p>\n<\/section>\n

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\n
\n

CCR4-CCL22\u9014\u5f84\u662f\u80bf\u7624\u5185Treg\u62db\u52df\u7684\u4e3b\u8981\u673a\u5236\u3002\u5b9e\u9645\u4e0a\uff0cTreg\u7684\u8fd0\u8f93\u548c\u6e17\u900f\u5230\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\u4e2d\uff0c\u4f3c\u4e4e\u4e0e\u80bf\u7624\u7ec6\u80de\u6216\u6d78\u6da6\u6027\u5de8\u566c\u7ec6\u80de\u4ea7\u751f\u7684CCR4\u914d\u4f53\uff08CCL17\u548cCCL22\uff09\u7684\u8868\u8fbe\u6c34\u5e73\u6709\u5173(Fig 29.2a<\/span>)\u3002\u6b64\u5916\uff0cCCR4\u4e3b\u8981\u5728\u9ad8\u8868\u8fbeFoxP3\u548cCD25\u3001CD45RA\u2212\u7684\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u8fd9\u4e9b\u88ab\u79f0\u4e3a\u6548\u5e94\u578bTregs\uff08ETregs\uff09\uff0c\u5728\u80bf\u7624\u6d78\u6da6\u6027\uff08TI\uff09FoxP3+<\/sup> T\u7ec6\u80de\u4e2d\u5360\u636e\u4e3b\u5bfc\u5730\u4f4d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n


<\/p>\n

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<\/p>\n<\/section>\n<\/section>\n

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Fig 29.2 <\/span><\/span>\u63cf\u8ff0\u4e86\u5982\u4f55\u963b\u65adTreg\u7ec6\u80de\u5411\u80bf\u7624\u7684\u52df\u96c6\u3002\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u6076\u6027\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\uff08\u4f8b\u5982\u5de8\u566c\u7ec6\u80de\uff09\u5206\u6ccc\u7684\u8d8b\u5316\u56e0\u5b50\u4f1a\u5438\u5f15\u5927\u91cf\u7684Tregs\u5230\u80bf\u7624\u533a\u57df\u3002\u7279\u522b\u662fCCL17\/CCL22-CCR4\uff08A\uff09\u548cCXCL12-CXCR4\uff08B\uff09\u8fd9\u4e24\u6761\u5173\u952e\u7684\u8d8b\u5316\u56e0\u5b50-\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u901a\u8def\uff0c\u662f\u76ee\u6807\u5316\u7597\u7684\u5173\u952e\u70b9\uff0c\u5305\u62ec\u4f7f\u7528\u7279\u5f02\u6027\u62ee\u6297\u5242\u5355\u6297\u3001\u8d8b\u5316\u56e0\u5b50\u6291\u5236\u5242\u53ca\u5176\u7c7b\u4f3c\u7269\uff08\u8fd9\u4e9b\u6cbb\u7597\u624b\u6bb5\u4e0e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u7ade\u4e89\u6027\u7ed3\u5408\uff09\u3002<\/span>\u901a\u8fc7\u963b\u65ad\u8fd9\u4e9b\u5173\u952e\u7684\u4fe1\u53f7\u901a\u8def\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u963b\u6b62Tregs\u5411\u80bf\u7624\u5927\u91cf\u8fc1\u79fb\uff0c\u4ece\u800c\u53ef\u80fd\u4fc3\u8fdb\u80bf\u7624\u7684\u6d88\u9000\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u5728\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CTCL\uff09\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cIto\u7b49\u4eba\u4f7f\u7528\u4e86\u6297CCR4\u62ee\u6297\u5242\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5e76\u5c55\u793a\u4e86\u901a\u8fc7\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u8bf1\u5bfc\u7684\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\u53ef\u4ee5\u663e\u8457\u8017\u5c3dTI Tregs\u3002\u5176\u4ed6\u7814\u7a76\u5c0f\u7ec4\u8fd8\u8868\u660e\uff0c\u901a\u8fc7CCR4\u62ee\u6297\u5242\u6291\u5236\u8868\u8fbeTreg\u7684CCR4\u7fa4\u4f53\u8db3\u4ee5\u6253\u7834\u5bf9\u81ea\u53d1\u6027\u4e73\u817a\u80bf\u7624\u7684\u514d\u75ab\u8010\u53d7\uff0c\u8fd9\u7a81\u663e\u4e86CCR4\u5728Treg\u7684\u514d\u75ab\u6291\u5236\u529f\u80fd\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\u3002\u603b\u4f53\u6765\u8bf4\uff0c\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u4e3aCCR4\u548cCCL22\u62ee\u6297\u5242\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u5c55\u63d0\u4f9b\u4e86\u7406\u8bba\u57fa\u7840\uff0c\u4ee5\u963b\u65adTreg\u7ec6\u80de\u5411\u80bf\u7624\u7684\u8fc1\u79fb\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5230\u76ee\u524d\u4e3a\u6b62\uff0cCCR4\u62ee\u6297\u5242\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u8868\u8fbeCCR4\u7684T\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5305\u62ec\u6210\u4ebaT\u7ec6\u80de\u767d\u8840\u75c5-\u6dcb\u5df4\u7624\uff08ATLL\uff09\u3001\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PTCL\uff09\u548cCTCL(Table 29.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n
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\n

Table 29.3<\/span><\/span> CCR4-\u9776\u5411\u6297\u4f53\u4e34\u5e8a\u5e94\u7528<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

Mogamulizumab(KW-0761)\u662f\u4e00\u79cd\u9488\u5bf9CCR4(\u56fe29.2a)\u7684\u8131\u7cd6\u4eba\u6e90\u5316IgG1\u5355\u6297\uff0c\u5176\u8bbe\u8ba1\u76ee\u7684\u662f\u53d1\u6325\u5f3a\u5927\u7684ADCC\u4f5c\u7528\u3002\u5b83\u5728I\u671f\u548cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u663e\u793a\u51fa\u826f\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5c24\u5176\u662f\u5728\u6cbb\u7597\u9884\u540e\u4e0d\u4f73\u7684CTCL\u4e2d\u8868\u73b0\u7a81\u51fa\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6700\u521d\u7684I\/II\u671f\u591a\u4e2d\u5fc3\u7814\u7a76\u5bf9\u83ab\u4f3d\u6155\u73e0\u5355\u6297\uff08Mogamulizumab\uff09\u8fdb\u884c\u4e86\u5242\u91cf\u9012\u589e\u8bd5\u9a8c\uff0c\u4ee5\u8bc4\u4f30\u5176\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\u5728\u5df2\u7ecf\u63a5\u53d7\u8fc7\u9884\u6cbb\u7597\u7684\u5916\u5468T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PTCL\uff09\u6216\u76ae\u80a4T\u7ec6\u80de\u6dcb\u5df4\u7624\uff08CTCL\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5373\u4f7f\u5728\u6700\u4f4e\u5242\u91cf0.1 mg\/kg\u65f6\uff0c\u6297CCR4\u5355\u514b\u9686\u6297\u4f53\u4e5f\u80fd\u6709\u6548\u8017\u5c3d\u5faa\u73af\u4e2d\u7684CCR4+<\/sup>\u6548\u5e94\u578b\u8c03\u8282T\u7ec6\u80de\uff08eTregs\uff09\uff0c\u5e76\u6062\u590d\u6297\u539f\u7279\u5f02\u6027\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u7684\u53cd\u5e94\u3002\u57fa\u4e8e\u8fd9\u4e9b\u79ef\u6781\u7684\u521d\u6b65\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u7ec4\u6700\u8fd1\u542f\u52a8\u4e86\u4e00\u9879III\u671f\u8bd5\u9a8c\uff0c\u6bd4\u8f83\u83ab\u4f3d\u6155\u73e0\u5355\u6297\u548c\u4f0f\u7acb\u8bfa\uff08\u4e00\u79cd\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\u6291\u5236\u5242\uff09\u5728\u6cbb\u7597CTCL\u4e2d\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08NCT01728805\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0cSun\u7b49\u4eba\u7684\u7814\u7a76\u6307\u51fa\uff0c\u4e0e\u5176\u4ed6CCR4\u7ed3\u5408\u914d\u4f53\u76f8\u6bd4\uff0c\u5728\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u60a3\u8005\u4e2d\uff0c\u5355\u6838\u7ec6\u80de\u7684MCP-1\u662f\u4e00\u79cd\u5185\u6e90\u6027CCR4\u7ed3\u5408\u914d\u4f53\uff0c\u5e76\u7279\u5f02\u6027\u9ad8\u8868\u8fbe\u3002\u7814\u7a76\u901a\u8fc7\u4f7f\u7528CCR4\u62ee\u6297\u5242\u963b\u65adMCP-1\/CCR4\u4fe1\u53f7\uff0c\u6291\u5236Treg\u7ec6\u80de\u7684\u52df\u96c6\uff0c\u53d1\u73b0\u8fd9\u79cd\u65b9\u6cd5\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u751f\u957f\u5e76\u5ef6\u957f\u751f\u5b58\u671f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u81ea2014\u5e74\u4ee5\u6765\uff0c\u83ab\u4f3d\u6155\u73e0\u5355\u6297\u5df2\u5728\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u764c\u60a3\u8005\u4e2d\u8fdb\u884c\u4e86\u7597\u6548\u8bc4\u4f30\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u5927\u591a\u91c7\u7528\u83ab\u4f3d\u6155\u73e0\u5355\u6297\u4e0e\u5176\u4ed6\u514d\u75ab\u6cbb\u7597\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u5305\u62ec\u6297PD-1\u3001\u6297PD-L1\u3001\u6297CTLA-4\u3001\u62974-1BB\u6297\u4f53\u4ee5\u53ca\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u9176\uff08IDO\uff09\u6291\u5236\u5242\uff0c\u4ee5\u63a2\u7d22\u5176\u534f\u540c\u6cbb\u7597\u6548\u679c(Table 29.3<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

29.4.2  \u963b\u65adCXCR4-CXCL12\u901a\u8def<\/p>\n<\/section>\n

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CXCL12\uff08\u4e5f\u79f0\u4e3a\u57fa\u8d28\u7ec6\u80de\u884d\u751f\u56e0\u5b50-1\uff0cSDF-1\uff09\u662f\u4e00\u79cd\u4e3b\u8981\u7531\u9aa8\u9ad3\u3001\u6dcb\u5df4\u7ed3\u548c\u708e\u75c7\u7ec6\u80de\u5206\u6ccc\u7684\u8d8b\u5316\u56e0\u5b50\uff0c\u8d1f\u8d23\u5f15\u5bfc\u8868\u8fbeCXCR4\u7684Treg\u7ec6\u80de\u8fc1\u79fb\u81f3\u7279\u5b9a\u7ec4\u7ec7\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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CXCL12-CXCR4\u901a\u8def\u5728\u8bb8\u591a\u4eba\u7c7b\u764c\u75c7\u4e2d\u626e\u6f14\u7740\u5173\u952e\u89d2\u8272\uff0c\u53c2\u4e0e\u80bf\u7624\u7ec6\u80de\u7684\u8fdb\u5c55\u3001\u8840\u7ba1\u751f\u6210\u548c\u8f6c\u79fb\u8fc7\u7a0b\uff0c\u5982\u9ed1\u8272\u7d20\u7624\u3001\u5375\u5de2\u764c\u3001\u4e73\u817a\u764c\u3001\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u80c3\u764c\u3002\u56e0\u6b64\uff0c\u7531\u4e8e\u5176\u4e0e\u764c\u75c7\u8f6c\u79fb\u548c\u4e0d\u826f\u4e34\u5e8a\u7ed3\u679c\u7684\u5173\u8054\uff0c\u963b\u65adCXCL12\u4e0eCXCR4\u7684\u76f8\u4e92\u4f5c\u7528\u6216\u6291\u5236\u5176\u4e0b\u6e38\u4fe1\u53f7\u4f20\u5bfc\u7684\u6cbb\u7597\u7b56\u7565\u6210\u4e3a\u4e86\u7814\u7a76\u7684\u70ed\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u76ee\u524d\uff0c\u591a\u79cd\u9488\u5bf9CXCL12\u901a\u8def\u7684\u836f\u7269\u6b63\u5728\u5f00\u53d1\u4e2d\uff0c\u5305\u62ecAMD3100\uff08\u4e5f\u79f0\u4e3aplerixafor\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u9ad8\u5ea6\u7279\u5f02\u7684CXCR4\u62ee\u6297\u5242\uff1bCTCE-9908\uff0c\u4e00\u79cd\u80fd\u591f\u4e0eCXCR4\u7ade\u4e89\u6027\u7ed3\u5408\u7684CXCL12\u7c7b\u4f3c\u7269\uff1b\u4ee5\u53caSpiegelmer\/NOX-A12\uff0c\u4e00\u79cdCXCL12\u6291\u5236\u5242(Fig. 29.2B<\/span>)\u3002\u5728\u8fd9\u4e9b\u836f\u7269\u4e2d\uff0cAMD3100\u548cCTCE-9908\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u767d\u8840\u75c5\u548c\u9aa8\u8089\u7624\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1\u7684\u7814\u7a76\u8fd8\u63ed\u793a\u4e86CXCL12-CXCR4\u901a\u8def\u5728\u80bf\u7624\u5bf9\u5e38\u89c4\u5316\u7597\u548c\u6297\u8840\u7ba1\u751f\u6210\u6cbb\u7597\u53d1\u5c55\u8010\u836f\u6027\u4e2d\u7684\u6f5c\u5728\u4f5c\u7528\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e9b\u8010\u836f\u6027\uff0c\u76ee\u524d\u6b63\u5728\u63a2\u7d22\u6d89\u53ca\u963b\u65adCXCL12\u901a\u8def\u7684\u7efc\u5408\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1\u5982\u6b64\uff0c\u76ee\u524d\u9488\u5bf9CXCL12-CXCR4\u901a\u8def\u963b\u65ad\u5bf9\u4eba\u7c7bTreg\u7ec6\u80de\u7fa4\u4f53\u5f71\u54cd\u7684\u7814\u7a76\u5c1a\u4e0d\u5145\u5206\uff0c\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u79d1\u5b66\u63a2\u7d22\u6765\u9a8c\u8bc1\u8fd9\u4e9b\u6cbb\u7597\u7b56\u7565\u7684\u6548\u679c\u53ca\u5176\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u7f57\u4f73\u4f73<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u6f58\u541b\u541b \u90ed\u9707\u8fdc<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n

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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5173\u6ce8\u672c\u53f7~<\/span>
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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c28\u7ae0\uff1a\u80bf\u7624\u7684\u5c40\u90e8\u514d\u75ab\u6cbb\u7597\uff08\u4e0b\uff09 29.1 \u5f15\u8a00 29.1.1  \u5c0f\u9f20\u548c\u4eba\u6e90…<\/p>\n","protected":false},"author":1,"featured_media":3584,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3589"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3589"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3589\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3584"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3589"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}