{"id":3603,"date":"2024-06-11T06:42:25","date_gmt":"2024-06-10T22:42:25","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2024\/06\/11\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac30%e7%ab%a0%ef%bc%9a%e6%94%be%e5%b0%84%e6%b2%bb%e7%96%97%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e7%9a%84%e5%8d%8f%e5%90%8c%e4%bd%9c-2\/"},"modified":"2024-06-11T06:42:25","modified_gmt":"2024-06-10T22:42:25","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac30%e7%ab%a0%ef%bc%9a%e6%94%be%e5%b0%84%e6%b2%bb%e7%96%97%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e7%9a%84%e5%8d%8f%e5%90%8c%e4%bd%9c-2","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2024\/06\/11\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac30%e7%ab%a0%ef%bc%9a%e6%94%be%e5%b0%84%e6%b2%bb%e7%96%97%e4%b8%8e%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e7%9a%84%e5%8d%8f%e5%90%8c%e4%bd%9c-2\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c30\u7ae0\uff1a\u653e\u5c04\u6cbb\u7597\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u534f\u540c\u4f5c\u7528\uff08\u4e0b\uff09"},"content":{"rendered":"
\n
\n
\n
\n
\n

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c30\u7ae0\uff1a\u653e\u5c04\u6cbb\u7597\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u534f\u540c\u4f5c\u7528\uff08\u4e0a\uff09<\/span><\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

30.6 \u5e73\u8861\u884c\u4e3a\uff1a\u8f90\u5c04\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8bf1\u53d1\u7684\u6297\u80bf\u7624\u514d\u75ab\u7684\u8d1f\u5411\u8c03\u8282\u56e0\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u514d\u75ab\u4ecb\u5bfc\u7684\u80bf\u7624\u9003\u9038\u5bfc\u81f4\u80bf\u7624\u8fdb\u5c55\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u6d89\u53ca\u591a\u79cd\u514d\u75ab\u6291\u5236\u9014\u5f84\uff0c\u4e0d\u540c\u80bf\u7624\u5728\u5229\u7528\u8fd9\u4e9b\u9014\u5f84\u4e0a\u5404\u6709\u5dee\u5f02\u3002\u867d\u7136\u8f90\u5c04\u6cbb\u7597\u53ef\u4ee5\u7f13\u89e3\u6216\u62b5\u6297\u5176\u4e2d\u4e00\u4e9b\u6291\u5236\u673a\u5236\uff0c\u4f46\u5b83\u4e5f\u53ef\u80fd\u52a0\u5267\u5176\u4ed6\u673a\u5236\u3002\u4f8b\u5982\uff0c\u8f90\u5c04\u901a\u8fc7\u8bf1\u5bfc\u6d3b\u6027\u6c27\uff08ROS\uff09\u5f15\u8d77\u7684\u6784\u8c61\u53d8\u5316\uff0c\u5bfc\u81f4\u6f5c\u5728TGF-\u03b2\u4ece\u4e0e\u5176\u7ed3\u5408\u7684\u6f5c\u4f0f\u76f8\u5173\u80bd\u4e2d\u89e3\u79bb\uff0c\u4ece\u800c\u5b9e\u73b0\u6025\u6027\u6fc0\u6d3b\u3002TGF-\u03b2\u662f\u4e00\u79cd\u5f3a\u6548\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\uff0c\u5bf9\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u5177\u6709\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u5728TGF-\u03b2\u7684\u5b58\u5728\u4e0b\uff0c\u6fc0\u6d3b\u7684\u521d\u7ea7CD4+ <\/sup>T\u7ec6\u80de\u53ef\u80fd\u8f6c\u5316\u4e3a\u8c03\u8282\u6027T\u7ec6\u80de\u3002\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u8f90\u5c04\u8bf1\u5bfc\u7684TGF-\u03b2\u6fc0\u6d3b\u662f\u5426\u4e0e\u4e00\u4e9b\u7814\u7a76\u6240\u62a5\u544a\u7684\u8f90\u5c04\u8bf1\u5bfc\u8c03\u8282\u6027T\u7ec6\u80de\u589e\u52a0\u6709\u76f4\u63a5\u5173\u8054\u3002\u6b64\u5916\uff0c\u6b63\u5982\u4e4b\u524d\u6240\u8ff0\uff0c\u901a\u8fc7TGF-\u03b2\u6291\u5236\u6811\u7a81\u7ec6\u80de\uff08DC\uff09\u7684\u6fc0\u6d3b\u662f\u8f90\u5c04\u5f15\u53d1\u7684\u6297\u80bf\u7624T\u7ec6\u80de\u53cd\u5e94\u7684\u4e00\u4e2a\u660e\u663e\u969c\u788d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7814\u7a76\u663e\u793a\uff0c\u5728\u524d\u5217\u817a\u764c\u4e2d\u8f90\u5c04\u4f1a\u8bf1\u5bfc\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\uff08CSF1\uff09\u7684\u4e0a\u8c03\uff0c\u5728\u80f0\u817a\u764c\u4e2d\u5219\u8bf1\u5bfcC-C\u57fa\u5e8f\u914d\u4f532\uff08CCL2\uff09\u7684\u4e0a\u8c03\uff0c\u8fd9\u4e9b\u53d8\u5316\u5747\u4f1a\u589e\u52a0\u9ad3\u7cfb\u7ec6\u80de\u5411\u80bf\u7624\u7684\u52df\u96c6\u3002\u8fd9\u4e9b\u88ab\u62db\u52df\u7684\u9ad3\u7cfb\u7ec6\u80de\u5206\u5316\u4e3a\u5177\u6709\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAMs\uff09\uff0c\u5e76\u53c2\u4e0e\u534f\u8c03\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u8fdb\u5c55\u7684\u7ec4\u7ec7\u4fee\u590d\u7a0b\u5e8f\u3002\u5728\u9ad8\u5242\u91cf\uff08\u8d85\u8fc710Gy\uff09\u7684\u8f90\u5c04\u540e\uff0c\u8fd9\u4e00\u8fc7\u7a0b\u56e0\u5e7f\u6cdb\u7684\u5185\u76ae\u7ec6\u80de\u6b7b\u4ea1\u800c\u88ab\u52a0\u5267\uff0c\u5c24\u5176\u662f\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\u3002\u6709\u8da3\u7684\u662f\uff0c\u5c3d\u7ba1\u8840\u7ba1\u7ec6\u80de\u7684\u6b7b\u4ea1\u4e0e\u9ad8\u5242\u91cf\u8f90\u5c04\u6cbb\u7597\u76f8\u5173\uff0c\u4f46\u6700\u8fd1\u4e00\u9879\u4f7f\u7528\u81ea\u53d1\u81f4\u764c\u6a21\u578b\u7684\u7814\u7a76\u8868\u660e\uff0c\u5f53\u5728\u5185\u76ae\u7ec6\u80de\u6216\u8089\u7624\u7ec6\u80de\u4e2d\u9009\u62e9\u6027\u5220\u9664ATM\uff08\u5931\u8c03-\u6bdb\u7ec6\u8840\u7ba1\u6269\u5f20\u7a81\u53d8\uff09\u57fa\u56e0\u65f6\uff0c\u7acb\u4f53\u5b9a\u5411\u653e\u5c04\u6cbb\u7597\uff08SBRT\uff09\u5e76\u672a\u63d0\u9ad8\u8fd9\u4e9b\u7f3a\u5931ATM\u7684\u5185\u76ae\u7ec6\u80de\u7684\u6b7b\u4ea1\u7387\u3002\u5c3d\u7ba1\u8fd9\u9879\u7814\u7a76\u672a\u8bc4\u4f30\u514d\u75ab\u7cfb\u7edf\u5728\u80bf\u7624\u6839\u9664\u4e2d\u7684\u4f5c\u7528\uff0c\u4f46\u63a2\u8ba8ATM\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u662f\u5426\u5728\u80bf\u7624\u6839\u9664\u4e2d\u53d1\u6325\u4f5c\u7528\u5c06\u662f\u4e00\u4e2a\u6709\u8da3\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6b64\u5916\uff0c\u8f90\u5c04\u8fd8\u80fd\u4e0a\u8c03\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50-1\u03b1\uff08HIF1-\u03b1\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u5173\u952e\u7684\u8f6c\u5f55\u56e0\u5b50\uff0c\u5b83\u4e0d\u4ec5\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\uff0c\u8fd8\u80fd\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u548c\u9ad3\u7cfb\u7ec6\u80de\u8868\u8fbePD-L1\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u4ecb\u5bfc\u7684\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u56e0\u6b64\uff0c\u8f90\u5c04\u7684\u5f71\u54cd\u6781\u5176\u590d\u6742\uff0c\u53d6\u51b3\u4e8e\u591a\u4e2a\u53d8\u91cf\uff0c\u5305\u62ec\u80bf\u7624\u7c7b\u578b\u3001\u539f\u6709\u7684\u80bf\u7624\u5fae\u73af\u5883\u4ee5\u53ca\u4f7f\u7528\u7684\u8f90\u5c04\u5242\u91cf\u3002\u6df1\u5165\u7406\u89e3\u8fbe\u5230\u514d\u75ab\u6fc0\u6d3b\u4e0e\u514d\u75ab\u6291\u5236\u4fe1\u53f7\u5e73\u8861\u7684\u6cbb\u7597\u65b9\u6848\u548c\u7ec4\u5408\u7b56\u7565\uff0c\u5bf9\u4e8e\u6700\u4f73\u5229\u7528\u653e\u5c04\u6cbb\u7597\u4f5c\u4e3a\u539f\u4f4d\u80bf\u7624\u75ab\u82d7\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

30.7 \u91cd\u65b0\u5ba1\u89c6\u5f53\u524d\u6cbb\u7597\u65b9\u6848\uff1a\u5c40\u90e8\u653e\u7597\u5f15\u53d1\u7684\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u7ed3\u5408\u653e\u5c04\u6cbb\u7597\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\u65f6\uff0c\u4e00\u4e2a\u91cd\u8981\u7684\u5b9e\u9645\u8003\u8651\u56e0\u7d20\u662f\u88ab\u7167\u5c04\u7ec4\u7ec7\u7684\u4f53\u79ef\u6216\u201c\u573a\u5927\u5c0f\u201d\u3002\u6b63\u5982\u672c\u7ae0\u521d\u6240\u8ba8\u8bba\u7684\uff0c\u4f20\u7edf\u7684\u653e\u5c04\u6cbb\u7597\u6280\u672f\u901a\u5e38\u91c7\u7528\u5e7f\u6cdb\u7684\u8f90\u5c04\u8303\u56f4\uff0c\u5305\u62ec\u6db5\u76d6\u5f15\u6d41\u6dcb\u5df4\u7ed3\u3001\u90bb\u8fd1\u9aa8\u9abc\u4ee5\u53ca\u9020\u8840\u9aa8\u9ad3\u3002\u5c3d\u7ba1\u8fd9\u79cd\u65b9\u6cd5\u65e8\u5728\u5305\u62ec\u80bf\u7624\u8fb9\u7f18\u7684\u5fae\u89c2\u75c5\u53d8\uff0c\u4f46\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u4f8b\u5982\u665a\u671f\u5934\u9888\u764c\uff0c\u5c40\u90e8\u590d\u53d1\u7387\u4ecd\u9ad8\u8fbe\u7ea640%\uff0c\u5373\u4fbf\u662f\u5728\u603b\u5242\u91cf\u5927\u3001CTV\u5e7f\u3001\u77ed\u671f\u548c\u957f\u671f\u6bd2\u6027\u663e\u8457\u7684\u60c5\u51b5\u4e0b\u3002\u4f20\u7edf\u7684\u653e\u5c04\u751f\u7269\u5b66\u5e38\u5e38\u5c06\u8fd9\u4e9b\u6cbb\u7597\u5931\u8d25\u5f52\u548e\u4e8e\u8f90\u5c04\u5242\u91cf\u4e0d\u8db3\u6216\u7167\u5c04\u8303\u56f4\u8fb9\u7f18\u4e0d\u8db3\u3002\u7136\u800c\uff0c\u968f\u7740\u5bf9\u8f90\u5c04\u5728\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u4ee5\u63a7\u5236\u764c\u7ec6\u80de\u65b9\u9762\u4f5c\u7528\u7684\u8ba4\u8bc6\u52a0\u6df1\uff0c\u8fd9\u79cd\u6a21\u5f0f\u6b63\u5728\u88ab\u91cd\u65b0\u8bc4\u4f30\u3002\u5927\u8303\u56f4\u8f90\u5c04\u7684\u4e00\u4e2a\u4e3b\u8981\u526f\u4f5c\u7528\u662f\u5728\u8f90\u7167\u533a\u57df\u5185\u6740\u6b7b\u9a7b\u7559\u6216\u5faa\u73af\u7684\u6dcb\u5df4\u7ec6\u80de\uff08\u5728\u8f90\u5c04\u4f20\u9012\u8fc7\u7a0b\u4e2d\u88ab\u66b4\u9732\uff09\u3002\u7531\u4e8e\u6dcb\u5df4\u7ec6\u80de\u5bf9\u8f90\u5c04\u6781\u4e3a\u654f\u611f\uff0c\u5b83\u4eec\u7684\u51cf\u5c11\u964d\u4f4e\u4e86\u53c2\u4e0e\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u7684\u53ef\u7528\u7ec6\u80de\u6570\u91cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u653e\u5c04\u8bf1\u5bfc\u7684\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u5df2\u7ecf\u5728\u591a\u5f62\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u7814\u7a76\u4e2d\u5f97\u5230\u8bc1\u5b9e\uff0c\u8fd9\u79cd\u80bf\u7624\u901a\u5e38\u6d89\u53ca\u5927\u8111\u8fd9\u4e00\u9ad8\u5ea6\u704c\u6ce8\u7684\u5668\u5b98\uff0c\u5e76\u7ecf\u5e38\u63a5\u53d7\u5927\u8303\u56f4\u653e\u5c04\u6cbb\u7597\u3002\u5728\u63a5\u53d7\u6807\u51c6\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c40%\u53d1\u751f\u4e25\u91cd\u548c\u6301\u7eed\u7684\u6cbb\u7597\u76f8\u5173\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u3002\u91cd\u8981\u7684\u662f\uff0c\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u88ab\u8bc1\u5b9e\u4e0e\u751f\u5b58\u671f\u7f29\u77ed\u76f8\u5173\uff1aCD4\u8ba1\u6570\u57282\u4e2a\u6708\u5185\u4f4e\u4e8e200\u65f6\uff0c\u6b7b\u4ea1\u98ce\u9669\u6bd4\u4e3a1.66\uff08p=0.03\uff09\u3002\u8fd9\u4e00\u53d1\u73b0\u7a81\u663e\u4e86\u5728\u8bbe\u8ba1\u6cbb\u7597\u65b9\u6848\u65f6\u8003\u8651\u514d\u75ab\u4fdd\u62a4\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4e00\u9879\u9884\u6d4b\u8840\u6db2\u5f71\u54cd\u7684\u6a21\u578b\u7814\u7a76\u4e2d\uff0c\u8ba1\u7b97\u51fa\u5faa\u73af\u6dcb\u5df4\u7ec6\u80de\u7684\u5e73\u5747\u8f90\u5c04\u5242\u91cf\u4e3a2.2 Gy\uff0c\u5e76\u4e14\u572830\u6b21\u6cbb\u7597\u540e\uff0c\u6839\u636e\u4f7f\u7528\u7684\u8f90\u5c04\u8303\u56f4\uff0c\u670999%\u7684\u5faa\u73af\u8840\u6db2\u63a5\u53d7\u4e86\u81f3\u5c110.5 Gy\u7684\u8f90\u5c04\u3002\u4e3a\u4e86\u7814\u7a76\u5c40\u90e8\u665a\u671f\u80f0\u817a\u764c\u6cbb\u7597\u8fb9\u7f18\u5bf9\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u7684\u5f71\u54cd\uff0c\u6700\u8fd1\u5bf9\u7acb\u4f53\u5b9a\u5411\u653e\u5c04\u6cbb\u7597\u4e0e\u6807\u51c6\u4e09\u7ef4\u653e\u5c04\u6cbb\u7597\u57df\u7684\u603b\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e24\u4e2a\u6708\u65f6\uff0c\u4e0e\u7acb\u4f53\u5b9a\u5411\u6cbb\u7597\u76f8\u6bd4\uff0c\u6807\u51c6\u6cbb\u7597\u7ec4\u4e2d\u670946%\u7684\u60a3\u8005\u6dcb\u5df4\u7ec6\u80de\u6570\u663e\u8457\u51cf\u5c11\uff0c\u4e0e13.6%\u7684\u60a3\u8005\u76f8\u6bd4\u3002\u6b64\u5916\uff0c\u6cbb\u7597\u540e\u8f83\u9ad8\u7684\u603b\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u4e0e\u751f\u5b58\u671f\u7684\u5ef6\u957f\u663e\u8457\u76f8\u5173\uff0c\u8fd9\u8fdb\u4e00\u6b65\u8868\u660e\u4e86\u5927\u8303\u56f4\u6cbb\u7597\u533a\u57df\u7684\u4e0d\u5229\u5f71\u54cd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u653e\u5c04\u6cbb\u7597\u671f\u95f4\u7167\u5c04\u5faa\u73afT\u7ec6\u80de\u53ef\u80fd\u5bf9\u514d\u75ab\u8bb0\u5fc6\u7684\u7ef4\u6301\u4ea7\u751f\u663e\u8457\u5f71\u54cd\uff0c\u800c\u514d\u75ab\u8bb0\u5fc6\u4f9d\u8d56\u4e8e\u6301\u7eed\u7684\u7ec6\u80de\u7a33\u6001\u8f6c\u6362\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u62a5\u544a\u6307\u51faT\u7ec6\u80de\u7684\u529f\u80fd\u53ef\u80fd\u53d7\u5230\u635f\u5bb3\u3002\u4ece\u60a3\u8005\u5916\u5468\u8840\u4e2d\u91c7\u96c6\u7684T\u7ec6\u80de\u5728\u4f53\u5916\u91cd\u65b0\u523a\u6fc0\u540e\uff0c\u5176\u589e\u6b96\u80fd\u529b\u51cf\u5f31\uff0c\u4e14\u5728\u653e\u5c04\u6cbb\u7597\u7ed3\u675f\u56db\u5468\u540e\u4ecd\u53ef\u68c0\u6d4b\u5230\u8fd9\u79cd\u635f\u4f24\u3002\u653e\u7597\u540e\u6dcb\u5df4\u7ec6\u80de\u7684\u6301\u7eed\u51cf\u5c11\u4e0e\u7ec6\u80de\u56e0\u5b50\u53cd\u5e94\u6301\u7eed\u5931\u8d25\u6709\u5173\u3002\u56e0\u6b64\uff0c\u5728\u8bbe\u8ba1\u653e\u5c04\u6cbb\u7597\u65b9\u6848\u65f6\u8003\u8651\u7167\u5c04\u7ec4\u7ec7\u7684\u4f53\u79ef\u548c\u6cbb\u7597\u7684\u5206\u6570\u663e\u5f97\u5c24\u4e3a\u5173\u952e\u3002\u521d\u6b65\u8bc1\u636e\u8868\u660e\uff0c\u4f20\u7edf\u7684\u5206\u5272\u653e\u5c04\u6cbb\u7597\u65b9\u6848\u5e94\u907f\u514d\u5c06\u6bcf\u65e5\u6cbb\u7597\u5ef6\u957f\u81f34-8\u5468\uff0c\u5c24\u5176\u662f\u5f53\u7167\u5c04\u5927\u9776\u4f53\u79ef\u65f6\u3002\u8fd9\u4e00\u70b9\u5bf9\u4e8e\u653e\u5c04\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\u6210\u529f\u7ec4\u5408\u81f3\u5173\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

30.8 \u5229\u7528\u8f90\u5c04\u6548\u5e94\u63d0\u9ad8\u514d\u75ab\u6cbb\u7597\u7684\u53cd\u5e94<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u542f\u52a8\u671f\u548c\u6548\u5e94\u671f\u53d7\u5230\u591a\u4e2a\u68c0\u67e5\u70b9\u7684\u8c03\u63a7\uff0c\u8fd9\u4e9b\u68c0\u67e5\u70b9\u5fc5\u987b\u88ab\u514b\u670d\u4ee5\u4ea7\u751f\u4e34\u5e8a\u6709\u6548\u7684\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u3002\u76ee\u524d\uff0c\u5df2\u6279\u51c6\u6216\u6b63\u5728\u7814\u7a76\u7684\u514d\u75ab\u7597\u6cd5\u9488\u5bf9\u4e00\u4e2a\u6216\u51e0\u4e2a\u8fd9\u6837\u7684\u68c0\u67e5\u70b9\uff0c\u4f46\u5728\u5f88\u591a\u60c5\u51b5\u4e0b\u8fd9\u4e9b\u6cbb\u7597\u672a\u80fd\u5f15\u53d1\u663e\u8457\u7684\u4e34\u5e8a\u53cd\u5e94\u3002\u653e\u5c04\u6cbb\u7597\u5728\u514d\u75ab\u53cd\u5e94\u7684\u542f\u52a8\u671f\u548c\u6548\u5e94\u671f\u90fd\u5177\u6709\u6f5c\u5728\u7684\u8c03\u8282\u4f5c\u7528\uff0c\u8fd9\u4f7f\u5f97\u5b83\u5728\u4e0e\u5404\u79cd\u514d\u75ab\u7597\u6cd5\u7ec4\u5408\u65f6\u663e\u793a\u51fa\u7279\u522b\u7684\u4f18\u52bf\u3002\u76f8\u5173\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u793a\u4f8b\u5217\u5728Table 30.1<\/span>\u4e2d\u3002\u867d\u7136Table 30.1<\/span>\u5e76\u672a\u6db5\u76d6\u6240\u6709\u76f8\u5173\u6587\u732e\uff0c\u4f46\u6240\u63d0\u4f9b\u7684\u6570\u636e\u5f3a\u6709\u529b\u5730\u652f\u6301\u4e86\u653e\u5c04\u6cbb\u7597\u53ef\u4ee5\u4e0e\u4e0d\u540c\u7b56\u7565\u534f\u540c\u4f5c\u7528\u4ee5\u63d0\u9ad8\u80bf\u7624\u63a7\u5236\u7684\u5047\u8bbe\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6709\u8da3\u7684\u662f\uff0c\u4e0d\u540c\u7814\u7a76\u4e2d\u6d4b\u8bd5\u7684\u653e\u5c04\u5242\u91cf\u5dee\u5f02\u5f88\u5927\uff0c\u4f46\u53ea\u6709\u5c11\u6570\u7814\u7a76\u540c\u65f6\u6d4b\u8bd5\u4e86\u4e0d\u540c\u7684\u5242\u91cf\u548c\u5206\u5272\u65b9\u6cd5\uff0c\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e9b\u7814\u7a76\u5e76\u672a\u80fd\u660e\u786e\u6700\u6709\u6548\u7684\u5242\u91cf\u3002\u6b64\u5916\uff0c\u53ea\u6709\u6781\u5c11\u6570\u7814\u7a76\u8be6\u7ec6\u68c0\u67e5\u4e86\u8fd9\u4e9b\u6cbb\u7597\u7ec4\u5408\u5bf9\u4f53\u5916\u80bf\u7624\u6a21\u578b\u7684\u5f71\u54cd\u3002\u5c3d\u7ba1\u573a\u5185\u63a7\u5236\u662f\u5b9e\u73b0\u8fdc\u9694\u6548\u5e94\u7684\u5fc5\u8981\u6761\u4ef6\uff0c\u4f46\u589e\u5f3a\u7684\u573a\u5185\u53cd\u5e94\u5e76\u4e0d\u4e00\u5b9a\u80fd\u8f6c\u5316\u4e3a\u7cfb\u7edf\u6027\u7684\u6cbb\u7597\u6548\u679c\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u5e94\u8c28\u614e\u5730\u5229\u7528\u4e34\u5e8a\u524d\u6570\u636e\u6765\u63a8\u65ad\u54ea\u4e9b\u8f90\u5c04\u5242\u91cf\u5e94\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u6d4b\u8bd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Table30.1 <\/span><\/span>\u5c55\u793a\u4e86\u5728\u4e34\u5e8a\u524d\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u653e\u5c04\u6cbb\u7597\u5982\u4f55\u6539\u5584\u5bf9\u591a\u79cd\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\u3002<\/span>CEA\uff1a\u764c\u80da\u6297\u539f\uff1b<\/span>CpG\uff1aC-G\u5bcc\u96c6\u7684\u5408\u6210\u5be1\u8131\u6c27\u6838\u82f7\u9178\uff1bCTLA-4\uff1aT\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff1bDC\uff1a\u6811\u7a81\u72b6\u7ec6\u80de\uff1bGM-CSF\uff1a\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff1bi.p.\uff1a\u8179\u8154\u6ce8\u5c04\uff1bi.v.\uff1a\u9759\u8109\u6ce8\u5c04\uff1bMDSC\uff1a\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff1bMHC\uff1a\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u4f53\uff1bNK\uff1a\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff1bPD-1\uff1a\u7a0b\u5e8f\u6027\u6b7b\u4ea1-1\uff1b\u76ae\u4e0b\u6ce8\u5c04\uff1bTAM\uff1a\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff1bTLR\uff1aToll\u6837\u53d7\u4f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

30.9 \u653e\u5c04\u6cbb\u7597\u4e0e\u514d\u75ab\u6cbb\u7597\u7ec4\u5408\u7684\u4e34\u5e8a\u8f6c\u5316\uff1a\u4e00\u9879\u8fdb\u884c\u4e2d\u7684\u5de5\u4f5c<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u663e\u793a\u51fa\u76f8\u52a0\u6027\u6216\u534f\u540c\u6548\u679c\u7684\u653e\u5c04\u4e0e\u514d\u75ab\u6cbb\u7597\u7ec4\u5408\uff0c\u76ee\u524d\u5df2\u5728\u4e34\u5e8a\u4e0a\u8fdb\u884c\u4e86\u6d4b\u8bd5\u3002\u5f00\u521b\u6027\u7684\u7814\u7a76\u6d4b\u8bd5\u4e86\u4f7f\u7528\u751f\u957f\u56e0\u5b50\uff08\u5982\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff0cGM-CSF\uff09\u6216TLR\u6fc0\u52a8\u5242\uff08\u5982CpG\uff09\u6765\u589e\u5f3a\u6297\u539f\u5448\u9012\u7ec6\u80de\u529f\u80fd\u548c\/\u6216\u6fc0\u6d3b\u7684\u7b56\u7565\uff0c\u8fd9\u5728\u5b9e\u4f53\u7624\u548c\u6dcb\u5df4\u7624\u4e2d\u5206\u522b\u5b9e\u73b0\u4e86\u63a5\u8fd130%\u7684\u8fdc\u9694\u6548\u5e94\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6700\u8fd1\uff0c\u9488\u5bf9CTLA-4\u548cPD-1\u4fe1\u53f7\u901a\u8def\u7684\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u6210\u529f\uff0c\u5bfc\u81f4FDA\u8fc5\u901f\u6279\u51c6\u4e86\u591a\u79cd\u836f\u7269\uff08\u5305\u62ecnivolumab\u3001pembrolizumab\u3001ipilimumab\u548catezolizumab\uff09\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3001\u80ba\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u5c3f\u9053\u4e0a\u76ae\u764c\u3001\u5934\u9888\u764c\u548c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002\u7136\u800c\uff0c\u6839\u636e\u4e0d\u540c\u7684\u75be\u75c5\u7c7b\u578b\uff0c\u5355\u4e00\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53cd\u5e94\u7387\u5927\u7ea6\u4fdd\u6301\u572815-30%\u5de6\u53f3\uff0c\u5e76\u4e14\u5728\u591a\u6570\u60c5\u51b5\u4e0b\u4f1a\u51fa\u73b0\u8010\u836f\u6027\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u6709\u8fd1100\u9879\u8bd5\u9a8c\u6b63\u5728\u7814\u7a76\u8f90\u5c04\u4e0e\u8fd9\u4e9b\u836f\u7269\u8054\u5408\u4f7f\u7528\u662f\u5426\u80fd\u591f\u514b\u670d\u8010\u836f\u6027\uff0c\u4ee5\u53ca\u662f\u5426\u80fd\u591f\u4ea7\u751f\u66f4\u4e3a\u5f3a\u70c8\u548c\u6301\u4e45\u7684\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u4e9b\u7814\u7a76\u5927\u591a\u6570\u5904\u4e8eI\/II\u671f\u9636\u6bb5\uff1b\u7136\u800c\uff0c\u76ee\u524d\u4e5f\u6709\u9488\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NCT02768558\uff09\u3001\u5934\u9888\u764c\uff08NCT03040999\uff09\u548c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08NCT02617589\uff09\u7684III\u671f\u7814\u7a76\u5728\u6d4b\u8bd5\u8f90\u5c04\u548cPD-1\u6291\u5236\u5242\u7ec4\u5408\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4e00\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c799\u540d\u63a5\u53d7\u591a\u897f\u4ed6\u8d5b\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u53bb\u52bf\u62b5\u6297\u6027\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u60a3\u8005\u88ab\u968f\u673a\u5206\u4e3a\u4e24\u7ec4\u3002\u8fd9\u4e24\u7ec4\u60a3\u8005\u5206\u522b\u63a5\u53d7\u4e86\u5355\u6b218 Gy\u9488\u5bf9\u9aa8\u8f6c\u79fb\u7684\u653e\u5c04\u6cbb\u7597\uff0c\u968f\u540e\u6bcf\u4e09\u5468\u63a5\u53d7\u4e00\u6b21\u4f0a\u5339\u5355\u6297\uff0810 mg\/kg\uff09\u6216\u5b89\u6170\u5242\uff0c\u6700\u591a\u63a5\u53d7\u56db\u6b21\u3002\u4e0e\u63a5\u53d7\u5b89\u6170\u5242\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u63a5\u53d7\u4f0a\u5339\u5355\u6297\u7684\u7ec4\u4e2d\u5e76\u672a\u89c2\u5bdf\u5230\u663e\u8457\u7684\u751f\u5b58\u7387\u63d0\u9ad8\u3002\u7136\u800c\uff0c\u5728\u5177\u6709\u8f83\u597d\u9884\u540e\u7279\u5f81\u4e14\u65e0\u5185\u810f\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\uff0c\u4f0a\u5339\u5355\u6297\u63d0\u9ad8\u4e86\u4e2d\u4f4d\u751f\u5b58\u671f\uff0c\u8fd9\u63d0\u793a\u9009\u62e9\u75c5\u60c5\u8f83\u8f7b\u4e14\u53ef\u80fd\u5177\u6709\u8f83\u597d\u514d\u75ab\u529f\u80fd\u7684\u60a3\u8005\u8fdb\u884c\u6b64\u7c7b\u6cbb\u7597\u53ef\u80fd\u5341\u5206\u91cd\u8981\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u6b64\u5916\uff0c\u5df2\u6709\u4e24\u9879I\u671f\u8bd5\u9a8c\u7684\u7ed3\u679c\u53d1\u5e03\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u6d4b\u8bd5\u4e86\u653e\u7597\u4e0e\u4f0a\u5339\u5355\u6297\u8054\u5408\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6548\u679c\uff0c\u6bcf\u9879\u8bd5\u9a8c\u5747\u7eb3\u5165\u4e8622\u540d\u60a3\u8005\u3002\u5728\u8fd9\u4e24\u9879\u7814\u7a76\u4e2d\uff0c\u89c2\u5bdf\u5230\u7684\u6bd2\u6027\u4e0e\u5355\u72ec\u4f7f\u7528\u4f0a\u5339\u5355\u6297\u7684\u9884\u671f\u6bd2\u6027\u76f8\u4f3c\u3002\u5728\u7b2c\u4e00\u9879\u7814\u7a76\u4e2d\uff0c18%\u7684\u60a3\u8005\u5b9e\u73b0\u4e86\u90e8\u5206\u7f13\u89e3\uff08\u8fd9\u662f\u6700\u4f73\u7ed3\u679c\uff09\uff0c\u53e6\u591618%\u7684\u60a3\u8005\u5728\u672a\u63a5\u53d7\u653e\u7597\u7684\u75c5\u7076\u4e2d\u75c5\u60c5\u7a33\u5b9a\uff0c\u8fd9\u4e0e\u5355\u7528\u4f0a\u5339\u5355\u6297\u7684\u9884\u671f\u6548\u679c\u76f8\u4f3c\u3002\u5728\u7b2c\u4e8c\u9879\u7814\u7a76\u4e2d\uff0c27.3%\u7684\u60a3\u8005\u5b9e\u73b0\u4e86\u5ba2\u89c2\u7f13\u89e3\uff0c\u5176\u4e2d\u5305\u62ec3\u4f8b\u5b8c\u5168\u7f13\u89e3\u548c3\u4f8b\u90e8\u5206\u7f13\u89e3\uff0c\u53e6\u670922.7%\u7684\u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\u3002\u5355\u72ec\u4f7f\u7528\u4f0a\u5339\u5355\u6297\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4e2d\u5f88\u5c11\u89c1\u5230\u5b8c\u5168\u7f13\u89e3\uff0c\u8fd9\u8868\u660e\u653e\u5c04\u6cbb\u7597\u53ef\u80fd\u786e\u5b9e\u589e\u5f3a\u4e86\u6cbb\u7597\u6548\u679c\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e24\u9879\u7814\u7a76\u5728\u653e\u7597\u4e0e\u4f0a\u5339\u5355\u6297\u7ed9\u836f\u7684\u987a\u5e8f\u4e0a\u5b58\u5728\u5dee\u5f02\uff1a\u7b2c\u4e00\u9879\u7814\u7a76\u5728\u653e\u7597\u540e3-5\u5929\u7ed9\u836f\uff0c\u800c\u7b2c\u4e8c\u9879\u7814\u7a76\u5728\u653e\u7597\u524d5\u5929\u5185\u7ed9\u836f\uff0c\u8fd9\u6697\u793a\u4e86\u6cbb\u7597\u7684\u987a\u5e8f\u53ef\u80fd\u81f3\u5173\u91cd\u8981\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u4e5f\u5df2\u8bc1\u660e\u5728\u653e\u7597\u524d\u6216\u653e\u7597\u8fc7\u7a0b\u4e2d\u7ed9\u4e88\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6bd4\u653e\u7597\u540e\u7ed9\u4e88\u66f4\u4e3a\u6709\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT02239900\uff09\u7684I\u671f\u7ed3\u679c\u5df2\u516c\u5e03\uff0c\u8be5\u8bd5\u9a8c\u68c0\u6d4b\u4e86\u5728\u665a\u671f\u5b9e\u4f53\u80bf\u7624\u4e2d\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff0c8\u4f8b\uff09\u3001\u7ed3\u76f4\u80a0\u764c\uff084\u4f8b\uff09\u3001\u8089\u7624\uff083\u4f8b\uff09\u548c\u80be\u7ec6\u80de\u764c\uff083\u4f8b\uff09\uff0c\u517131\u540d\u60a3\u8005\u63a5\u53d7SBRT\u8054\u5408\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u7684\u4f53\u5916\u53cd\u5e94\u3002SBRT\u4ee512.5 Gy \u00d7 4\u6b21\u62166 Gy \u00d7 10\u6b21\u7684\u5242\u91cf\u914d\u6bd4\uff0c\u4e0e\u4f0a\u5339\u5355\u6297\u540c\u65f6\u7ed9\u4e88\u6216\u5728\u7b2c\u4e8c\u6b21\u7ed9\u836f\u540e1\u5468\u8fde\u7eed\u7ed9\u4e88\uff0c\u7528\u4e8e\u6cbb\u7597\u809d\u810f\u6216\u80ba\u90e8\u8f6c\u79fb\u3002\u670923%\u7684\u60a3\u8005\u83b7\u5f97\u4e34\u5e8a\u6548\u76ca\uff08\u975e\u8f90\u5c04\u533a\u75c5\u7076\u90e8\u5206\u7f13\u89e3\u6216\u75be\u75c5\u7a33\u5b9a\u6301\u7eed6\u4e2a\u6708\u4ee5\u4e0a\uff09\u3002\u8fd9\u4e00\u7ed3\u679c\u5bf9\u4e8e\u90a3\u4e9b\u5df2\u77e5\u5bf9\u4f0a\u5339\u5355\u6297\u65e0\u53cd\u5e94\u7684\u80bf\u7624\u7c7b\u578b\u6765\u8bf4\uff0c\u662f\u975e\u5e38\u9f13\u821e\u4eba\u5fc3\u7684\uff0c\u4f46\u8981\u786e\u5b9a\u8f90\u5c04\u5242\u91cf\u3001\u7167\u5c04\u90e8\u4f4d\u6216\u4f0a\u5339\u5355\u6297\u7684\u7ed9\u836f\u987a\u5e8f\u662f\u5426\u4f1a\u5f71\u54cd\u6548\u679c\uff0c\u76ee\u524d\u8fd8\u4e3a\u65f6\u5c1a\u65e9\u3002\u5916\u5468\u8840CD8+ <\/sup>T\u7ec6\u80de\u548cCD8\/CD4 T\u7ec6\u80de\u6bd4\u7387\u7684\u589e\u52a0\u4e0e\u4e34\u5e8a\u83b7\u76ca\u76f8\u5173\u3002\u6709\u8da3\u7684\u662f\uff0c\u63a5\u53d7\u809d\u810f\u653e\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u4e00\u4e9bT\u7ec6\u80de\u6fc0\u6d3b\u6807\u8bb0\u7269\u7684\u8868\u8fbe\u9ad8\u4e8e\u63a5\u53d7\u80ba\u90e8\u653e\u7597\u7684\u60a3\u8005\uff0c\u4f46\u8fd9\u4e00\u73b0\u8c61\u4ecd\u9700\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7814\u7a76\u56e2\u961f\u5728ASTRO\u4f1a\u8bae\u4e0a\u62a5\u544a\u4e86\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT02221739\uff09\u7684\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u6d4b\u8bd5\u4e86\u653e\u7597\u548c\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u5316\u7597\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002\u572821\u540d\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7\u4e866 Gy \u00d7 5\u6b21\u62169.5 Gy \u00d7 3\u6b21\u7684\u653e\u7597\uff0c\u5e76\u5728\u653e\u7597\u671f\u95f4\u7ed9\u4e88\u4e86\u9996\u5242\u4f0a\u5339\u5355\u6297\uff0c\u968f\u540e\u5b8c\u6210\u4e864\u4e2a\u5468\u671f\u7684\u4f0a\u5339\u5355\u6297\u6cbb\u7597\uff0c33%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u90e8\u5206\u6216\u5b8c\u5168\u7684\u5f02\u4f4d\u53cd\u5e94\u3002\u751f\u5b58\u968f\u8bbf\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u4f46\u8fd9\u9879\u5c0f\u578b\u7814\u7a76\u7684\u6570\u636e\u663e\u793a\uff0c\u653e\u7597\u523a\u6fc0\u4e86\u5bf9\u4f0a\u5339\u5355\u6297\u7684\u53cd\u5e94\uff0c\u5e76\u8868\u660e\u4e0e\u5355\u72ec\u4f7f\u7528\u4f0a\u5339\u5355\u6297\u76f8\u6bd4\uff0c\u8054\u5408\u6cbb\u7597\u53ef\u80fd\u66f4\u4e3a\u6709\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8054\u5408\u653e\u7597\u548c\u963b\u65ad\u5176\u4ed6\u514d\u75ab\u6291\u5236\u9014\u5f84\u7684\u7814\u7a76\u4e5f\u53d6\u5f97\u4e86\u6709\u5e0c\u671b\u7684\u7ed3\u679c\u3002\u7531\u4e8eTGF-\u03b2\u5728\u8f90\u5c04\u8bf1\u5bfc\u7ea4\u7ef4\u5316\u4e2d\u7684\u4f5c\u7528\u4ee5\u53ca\u5176\u6291\u5236\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u7684\u80fd\u529b\uff0c\u5b83\u6210\u4e3a\u4e00\u4e2a\u6709\u5438\u5f15\u529b\u7684\u9776\u70b9\u3002\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30\u6297\u4f53\u4e2d\u548cTGF\u03b2\u4ee5\u53caTGF\u03b2\u53d7\u4f53\u5c0f\u5206\u5b50\u6291\u5236\u5242\u4e0e\u653e\u7597\u8054\u5408\u4f7f\u7528\uff0c\u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08NCT01401062\uff09\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NCT02581787\uff09\u3001\u76f4\u80a0\u764c\uff08NCT02688712\uff09\u548c\u80f6\u8d28\u7624\uff08NCT01220271\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

TLR\u6fc0\u52a8\u5242\u5df2\u6210\u529f\u7528\u4e8e\u514b\u670d\u514d\u75ab\u6291\u5236\u7684\u80bf\u7624\u5fae\u73af\u5883\u3002\u4f8b\u5982\uff0cTLR7\u6fc0\u52a8\u5242\u54aa\u55b9\u83ab\u7279\u80fd\u589e\u5f3a\u6811\u7a81\u7ec6\u80de\u7684\u6210\u719f\u548c\u6297\u539f\u5448\u9012\u80fd\u529b\uff0c\u5e76\u4fc3\u8fdb\u5411Th1\u578b\u514d\u75ab\u54cd\u5e94\u7684\u504f\u5411\uff0c\u4ee5\u53ca\u589e\u52a0T\u7ec6\u80de\u7684\u5f52\u5de2\u3002\u5728\u4e73\u817a\u764c\u76ae\u80a4\u8f6c\u79fb\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u4e34\u5e8a\u524d\u6570\u636e\u8868\u660e\uff0c\u5916\u7528\u54aa\u55b9\u83ab\u7279\u4e0e\u4f4e\u5242\u91cf\u5206\u5272\u653e\u7597\u7ed3\u5408\uff0c\u5728CD8+ <\/sup>T\u7ec6\u80de\u4f9d\u8d56\u7684\u65b9\u5f0f\u4e2d\u6291\u5236\u80bf\u7624\u751f\u957f\uff0c\u5e76\u4e0e\u73af\u78f7\u9170\u80fa\u8bf1\u5bfc\u7684\u514d\u75ab\u8bb0\u5fc6\u5171\u540c\u4f5c\u7528\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u9488\u5bf9\u80f8\u58c1\u590d\u53d1\u6216\u76ae\u80a4\u8f6c\u79fb\u7684\u4e73\u817a\u764c\u60a3\u8005\u7684\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT01421017\uff09\u63d0\u4f9b\u4e86\u79d1\u5b66\u4f9d\u636e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

PD-1\/PD-L\u8f74\uff0c\u5305\u62ec\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u86cb\u767d1\uff08PD-1\uff09\u53ca\u5176\u914d\u4f53\uff08PD-L1\u548cPD-L2\uff09\uff0c\u662f\u7ef4\u6301\u5916\u5468\u8010\u53d7\u7684\u91cd\u8981\u751f\u7406\u673a\u5236\u4e4b\u4e00\u3002\u5b83\u5728\u63a7\u5236\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u89c4\u6a21\u65b9\u9762\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5e76\u5728\u51e0\u4e4e\u6240\u6709\u7c7b\u578b\u7684\u708e\u75c7\u72b6\u6001\u4e2d\u90fd\u6709\u6240\u6d89\u53ca\u3002PD-1\u5728\u6d3b\u5316\u7684T\u7ec6\u80de\u548cB\u7ec6\u80de\u4e0a\u8868\u8fbe\uff0c\u5176\u8868\u8fbe\u662f\u7531TCR\u4f9d\u8d56\u7684\u6fc0\u6d3b\u8bf1\u5bfc\u7684\uff0c\u5c3d\u7ba1\u8868\u8fbe\u6c34\u5e73\u548c\u6301\u7eed\u65f6\u95f4\u4f1a\u53d7\u5230\u6fc0\u52b1\u7684\u6027\u8d28\u548c\u6301\u7eed\u6027\u7684\u5f71\u54cd\u3002PD-L1\u548cPD-L2\u901a\u5e38\u7531\u4e00\u90e8\u5206\u5de8\u566c\u7ec6\u80de\u8868\u8fbe\uff0c\u4f46\u4e5f\u53ef\u4ee5\u5728\u591a\u79cd\u9020\u8840\u7ec6\u80de\u548c\u975e\u9020\u8840\u7ec6\u80de\u4e2d\u88ab\u5404\u79cd\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u8bf1\u5bfc\u3002PD-1\/PD-L1\u8f74\u53c2\u4e0e\u6291\u5236T\u7ec6\u80de\u7684\u6838\u5fc3\u529f\u80fd\uff0c\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3001\u7ec6\u80de\u589e\u6b96\u548c\u7ec6\u80de\u6bd2\u6027\u9897\u7c92\u7684\u5f62\u6210\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u57fa\u4e8e\u5728\u6cbb\u7597\u6dcb\u5df4\u7624\u4e2d\u4f7f\u7528TLR9\u6fc0\u52a8\u5242\u53ca\u80bf\u7624\u9776\u5411\u8f90\u5c04\u7684\u79ef\u6781\u6570\u636e\uff0c\u4e00\u9879\u65b0\u7814\u7a76\u65e8\u5728\u901a\u8fc7\u6dfb\u52a0Flt3L\u5e76\u5c06Toll\u6837\u53d7\u4f53\uff08TLR\uff09\u6fc0\u52a8\u5242\u66f4\u6362\u4e3apoly-ICLC\u6765\u6539\u5584\u4f4e\u7ea7\u522bB\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5176\u4e2dpoly-ICLC\u88ab\u8ba4\u4e3a\u662fFlt3L\u62db\u52df\u7684\u6811\u7a81\u7ec6\u80de\u7684\u6700\u4f73TLR\u6fc0\u52a8\u5242\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

30.10 \u4f7f\u7528\u653e\u5c04\u6cbb\u7597\u8bf1\u5bfc\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u57fa\u56e0\u7ec4\u4e2d\u7684\u7a81\u53d8\u6709\u65f6\u4f1a\u7f16\u7801\u51fa\u5177\u6709\u514d\u75ab\u539f\u6027\u7684\u86cb\u767d\u8d28\uff08\u5373\u65b0\u6297\u539f\uff09\uff0c\u8fd9\u4e9b\u65b0\u6297\u539f\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u6bcf\u4e2a\u80bf\u7624\u7279\u6709\u7684\u3002\u65b0\u6297\u539f\u4f5c\u4e3a\u6cbb\u7597\u9776\u6807\u975e\u5e38\u6709\u5438\u5f15\u529b\uff0c\u56e0\u4e3a\u5b83\u4eec\u901a\u5e38\u4e0d\u4f1a\u5f15\u8d77\u514d\u75ab\u7cfb\u7edf\u7684\u8010\u53d7\u6027\u53cd\u5e94\uff0c\u800c\u4e14\u80bf\u7624\u7684\u9009\u62e9\u6027\u8868\u8fbe\u8fd9\u4e9b\u65b0\u6297\u539f\u53ef\u4ee5\u6700\u5c0f\u5316\u81ea\u8eab\u514d\u75ab\u7684\u98ce\u9669\u3002\u7136\u800c\uff0c\u8bf1\u5bfc\u5bf9\u8fd9\u4e9b\u65b0\u6297\u539f\u7684\u514d\u75ab\u53cd\u5e94\u9700\u8981\u9ad8\u5ea6\u4e2a\u6027\u5316\u7684\u7b56\u7565\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u76f8\u8f83\u4e8e\u6df1\u5ea6\u6d4b\u5e8f\u548c\u751f\u7269\u4fe1\u606f\u5b66\u7684\u8ba1\u7b97\u673a\u9884\u6d4b\u65b9\u6cd5\uff0c\u653e\u5c04\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u66f4\u5feb\u901f\u3001\u7ecf\u6d4e\u7684\u65b9\u5f0f\u6765\u751f\u6210\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5173\u4e8e\u5982\u4f55\u4f7f\u7528\u653e\u5c04\u6cbb\u7597\u6765\u542f\u52a8\u6709\u6548\u7684\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u7684\u6700\u4f73\u65b9\u6cd5\u4ecd\u6709\u8bb8\u591a\u672a\u89e3\u51b3\u7684\u95ee\u9898\u3002\u76ee\u524d\u6b63\u5728\u79ef\u6781\u7814\u7a76\u7684\u65b9\u9762\u5305\u62ec\u7ec4\u7ec7\u5b66\u7279\u6027\u3001\u653e\u5c04\u5242\u91cf\u548c\u5206\u5272\u65b9\u5f0f\u3001\u7167\u5c04\u90e8\u4f4d\u3001\u6cbb\u7597\u987a\u5e8f\u4ee5\u53ca\u6240\u4f7f\u7528\u7684\u514d\u75ab\u7597\u6cd5\u3002\u6b64\u5916\uff0c\u60a3\u8005\u7684\u4e2a\u4f53\u7279\u6027\uff0c\u5982\u9057\u4f20\u80cc\u666f\u3001\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u7684\u591a\u6001\u6027\u3001\u80bf\u7624\u7684\u9057\u4f20\u548c\u8868\u89c2\u9057\u4f20\u7279\u5f81\u3001\u7ffb\u8bd1\u540e\u8c03\u63a7\u8def\u5f84\uff0c\u4ee5\u53ca\u5305\u62ec\u6e29\u5ea6\u3001\u4ee3\u8c22\u548c\u5fae\u751f\u7269\u7ec4\u5728\u5185\u7684\u73af\u5883\u56e0\u7d20\uff0c\u90fd\u53ef\u80fd\u5f71\u54cd\u653e\u5c04\u6cbb\u7597\u751f\u6210\u539f\u4f4d\u80bf\u7624\u75ab\u82d7\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8feb\u5207\u9700\u8981\u8bc6\u522b\u53ef\u9884\u6d4b\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4ee5\u4fbf\u4e3a\u60a3\u8005\u9009\u62e9\u548c\u5b9a\u5236\u6cbb\u7597\u65b9\u6848\u3002\u76ee\u524d\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u4e2d\uff0c\u5e7f\u6cdb\u4f7f\u7528PD-L1\u514d\u75ab\u67d3\u8272\u4f5c\u4e3a\u9884\u6d4b\u5e15\u59c6\u5355\u6297\u514d\u75ab\u6cbb\u7597\u53cd\u5e94\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u65b0\u5174\u7684\u751f\u7269\u6807\u5fd7\u7269\u5305\u62ec\u201c\u514d\u75ab\u8bc4\u5206\u201d\uff0c\u8fd9\u662f\u57fa\u4e8e\u6cbb\u7597\u524d\u80bf\u7624\u6837\u672c\u4e2d\u6d78\u6da6\u514d\u75ab\u7ec6\u80de\u7684\u7efc\u5408\u5206\u6790\uff0c\u5b83\u4e0d\u4ec5\u53cd\u6620\u4e86\u80bf\u7624\u5fae\u73af\u5883\u7684\u6574\u4f53\u514d\u75ab\u539f\u6027\uff0c\u8fd8\u53ef\u80fd\u6307\u660e\u54ea\u4e9b\u514d\u75ab\u7ec6\u80de\u662f\u6700\u4f73\u7684\u6cbb\u7597\u9776\u6807\uff08\u4f8b\u5982\uff0c\u80bf\u7624\u6291\u5236\u7684\u5de8\u566c\u7ec6\u80de\u4e0e\u8c03\u8282\u6027T\u7ec6\u80de\uff09\u3002\u9664\u4e86\u5fae\u73af\u5883\u6307\u6807\u5916\uff0c\u901a\u8fc7\u80bf\u7624\u7684\u7a81\u53d8\u8d1f\u8377\u6216\u65b0\u6297\u539f\u8d1f\u8377\u6765\u6d4b\u91cf\u80bf\u7624\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u7279\u5f81\u5df2\u663e\u793a\u51fa\u5176\u9884\u6d4b\u4ef7\u503c\u3002\u4f8b\u5982\uff0c\u5728NSCLC\u4e2d\uff0c\u8f83\u9ad8\u7684\u7a81\u53d8\u548c\u65b0\u6297\u539f\u8d1f\u8377\u5747\u9884\u793a\u7740\u5bf9\u6297PD-1\u514d\u75ab\u6cbb\u7597\u7684\u826f\u597d\u53cd\u5e94\u3002\u5177\u6709DNA\u4fee\u590d\u7f3a\u9677\uff08\u5982\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff09\u7684\u80bf\u7624\u4e5f\u8868\u73b0\u51fa\u66f4\u597d\u7684\u5bf9\u6297PD-1\u514d\u75ab\u6cbb\u7597\u7684\u53cd\u5e94\u3002\u6700\u540e\uff0c\u60a3\u8005\u4e4b\u95f4\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff08SNPs\uff09\uff0c\u8fd9\u4e9b\u4e0e\u80bf\u7624\u7a81\u53d8\u65e0\u5173\u7684\u5fae\u5c0f\u9057\u4f20\u5dee\u5f02\uff0c\u5176\u4f5c\u7528\u4e5f\u5f00\u59cb\u88ab\u8ba4\u8bc6\u5230\u3002\u4f8b\u5982\uff0cPD-L1\u4e2d\u7684SNPs\u5df2\u88ab\u8bc1\u5b9e\u5728\u9884\u6d4b\u5316\u7597\u53cd\u5e94\u4e2d\u5177\u6709\u6f5c\u5728\u4ef7\u503c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u867d\u7136\u5728\u8bca\u65ad\u65f6\u6df1\u5165\u4e86\u89e3\u60a3\u8005\u7684\u764c\u75c7\u514d\u75ab\u72b6\u6001\u548c\u9057\u4f20\u7279\u5f81\u975e\u5e38\u91cd\u8981\uff0c\u4f46\u5df2\u7ecf\u6e05\u695a\u5730\u8ba4\u8bc6\u5230\uff0c\u5373\u4f7f\u60a3\u8005\u5bf9\u514d\u75ab\u6cbb\u7597\u6709\u521d\u6b65\u53cd\u5e94\uff0c\u5927\u591a\u6570\u60a3\u8005\u6700\u7ec8\u8fd8\u662f\u4f1a\u51fa\u73b0\u75c5\u60c5\u8fdb\u5c55\u3002\u56e0\u6b64\uff0c\u63a2\u7a76\u514d\u75ab\u9003\u9038\u673a\u5236\u81f3\u5173\u91cd\u8981\u3002\u5c3d\u7ba1\u6700\u521d\u7684\u6d3b\u68c0\u548c\u8840\u6db2\u6d4b\u8bd5\u6709\u52a9\u4e8e\u4e3a\u9002\u5f53\u7684\u6cbb\u7597\u63d0\u4f9b\u6307\u5bfc\uff0c\u4f46\u9274\u4e8e\u80bf\u7624\u5728\u514d\u75ab\u538b\u529b\u4e0b\u7684\u9057\u4f20\u6f14\u53d8\u6216\u201c\u514d\u75ab\u7f16\u8f91\u201d\u53cd\u5e94\uff0c\u53ef\u80fd\u9700\u8981\u5728\u764c\u75c7\u8fdb\u5c55\u7684\u5404\u4e2a\u9636\u6bb5\u5bf9\u80bf\u7624\u548c\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u91c7\u6837\uff0c\u4ee5\u4fbf\u4e3a\u6cbb\u7597\u5e72\u9884\u63d0\u4f9b\u6570\u636e\u652f\u6301\u3002\u4e3a\u6b64\uff0c\u201c\u6db2\u4f53\u6d3b\u68c0\u201d\u6216\u5229\u7528\u5916\u5468\u8840\u6837\u672c\u4f5c\u4e3a\u80bf\u7624\u7fa4\u4f53\u7684\u4ee3\u8868\uff0c\u63d0\u4f9b\u4e86\u4e00\u79cd\u957f\u671f\u76d1\u6d4b\u60a3\u8005\u7684\u5fae\u521b\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u653e\u5c04\u6cbb\u7597\u548c\u514d\u75ab\u6cbb\u7597\u7684\u7ec4\u5408\u5728\u7279\u5b9a\u60c5\u51b5\u4e0b\u5c55\u73b0\u51fa\u663e\u8457\u6548\u679c\uff0c\u4f8b\u5982\u5728\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u5bf9\u665a\u671f\u5316\u7597\u96be\u6cbb\u6027\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u8fdb\u884c\u975e\u6d88\u878d\u6027\u7167\u5c04\u5e76\u8054\u5408\u4f7f\u7528\u56db\u5242\u4f0a\u5339\u5355\u6297\u6cbb\u7597\u540e\uff0c\u60a3\u8005\u8d85\u8fc7\u56db\u5e74\u4ecd\u65e0\u80bf\u7624\u590d\u53d1\uff0c\u8fd9\u4e00\u7ed3\u679c\u6fc0\u53d1\u4e86\u6781\u5927\u7684\u70ed\u60c5\u3002\u7136\u800c\uff0c\u6b64\u7c7b\u53cd\u5e94\u4ecd\u7136\u76f8\u5bf9\u7f55\u89c1\u3002\u7814\u7a76\u8005\u4ecd\u5728\u5b66\u4e60\u5982\u4f55\u6700\u4f73\u5730\u7ed3\u5408\u653e\u5c04\u548c\u514d\u75ab\u6cbb\u7597\uff0c\u5e76\u5728\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u4e2d\u8003\u8651\u4f17\u591a\u56e0\u7d20\u3002\u6700\u7ec8\uff0c\u5c06\u7531\u60a3\u8005\u7279\u5b9a\u7684\u56e0\u7d20\u6765\u6307\u5bfc\u6cbb\u7597\u65b9\u6848\u7684\u9009\u62e9\u548c\u5b9e\u65bd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u6f58\u541b\u541b<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u6f58\u541b\u541b<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n

<\/span>
<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c30\u7ae0\uff1a\u653e\u5c04\u6cbb\u7597\u4e0e\u514d\u75ab\u6cbb\u7597\u7684\u534f\u540c\u4f5c\u7528\uff08\u4e0a\uff09 30.6 \u5e73\u8861\u884c\u4e3a\uff1a\u8f90\u5c04\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8bf1\u53d1…<\/p>\n","protected":false},"author":1,"featured_media":3601,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3603"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3603"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3603\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3601"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3603"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}