{"id":3643,"date":"2024-08-15T06:31:06","date_gmt":"2024-08-14T22:31:06","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2024\/08\/15\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac36%e7%ab%a0-%e5%8d%b5%e5%b7%a2%e7%99%8c%e5%92%8c%e4%b9%b3%e8%85%ba%e7%99%8c%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e9%9d%a2%e4%b8%b4%e7%9a%84\/"},"modified":"2024-08-15T06:31:06","modified_gmt":"2024-08-14T22:31:06","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac36%e7%ab%a0-%e5%8d%b5%e5%b7%a2%e7%99%8c%e5%92%8c%e4%b9%b3%e8%85%ba%e7%99%8c%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e9%9d%a2%e4%b8%b4%e7%9a%84","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2024\/08\/15\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac36%e7%ab%a0-%e5%8d%b5%e5%b7%a2%e7%99%8c%e5%92%8c%e4%b9%b3%e8%85%ba%e7%99%8c%e5%85%8d%e7%96%ab%e6%b2%bb%e7%96%97%e9%9d%a2%e4%b8%b4%e7%9a%84\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c36\u7ae0 \u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u514d\u75ab\u6cbb\u7597\u9762\u4e34\u7684\u6311\u6218\uff08\u4e0a\uff09"},"content":{"rendered":"
\n
\n
\n
\n
\n

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c35\u7ae0 \u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\uff1a\u4e00\u4e2a\u4e0d\u65ad\u53d1\u5c55\u7684\u9886\u57df\uff08\u4e0b\uff09<\/span><\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

36.1 \u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u7684\u80bf\u7624\u5fae\u73af\u5883\u53ca\u6cbb\u7597\u9776\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u5fae\u73af\u5883\uff08Tumor Microenvironment, TME\uff09\u5728\u80bf\u7624\u7684\u53d1\u751f\u3001\u53d1\u5c55\u548c\u8f6c\u79fb\u4e2d\u626e\u6f14\u7740\u81f3\u5173\u91cd\u8981\u7684\u89d2\u8272\u3002Hanahan\u53ca\u5176\u56e2\u961f\u5f3a\u8c03\u4e86\u5404\u79cd\u57fa\u8d28\u7ec6\u80de\u5728\u80bf\u7624\u8fdb\u5c55\u4e2d\u7684\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5728\u8f6c\u79fb\u751f\u6001\u4f4d\u7684\u5f62\u6210\u3001\u4ee3\u8c22\u6fc0\u6d3b\u3001\u80bf\u7624\u7ec6\u80de\u8fc1\u79fb\u3001\u514d\u75ab\u8c03\u8282\u3001\u8840\u7ba1\u751f\u6210\u4ee5\u53ca\u57fa\u8d28\u91cd\u5851\u7b49\u65b9\u9762\uff0c\u8fd9\u4e9b\u8fc7\u7a0b\u5171\u540c\u4fc3\u8fdb\u4e86\u80bf\u7624\u7684\u751f\u957f\u548c\u7ef4\u6301\u3002TME\u7531\u57fa\u8d28\u7ec6\u80de\u3001\u7ec6\u80de\u5916\u57fa\u8d28\u548c\u591a\u79cd\u86cb\u767d\u8d28\u56e0\u5b50\u7ec4\u6210\u3002\u57fa\u8d28\u7ec6\u80de\u5305\u62ec\u8102\u80aa\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u514d\u75ab\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\uff1b\u7ec6\u80de\u5916\u57fa\u8d28\u5219\u7531\u900f\u660e\u8d28\u9178\u3001\u86cb\u767d\u805a\u7cd6\u548c\u7ea4\u7ef4\u6027\u86cb\u767d\uff08\u5982\u80f6\u539f\u86cb\u767d\u3001\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d\u548c\u5c42\u7c98\u8fde\u86cb\u767d\uff09\u6784\u6210\u3002\u86cb\u767d\u8d28\u56e0\u5b50\u6db5\u76d6\u4e86\u751f\u957f\u56e0\u5b50\u3001\u514d\u75ab\u7403\u86cb\u767d\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u7b49\u3002\u5728\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u4e2d\uff0c\u80bf\u7624\u76f8\u5173\u7684\u57fa\u8d28\u7ec6\u80de\u6709\u591a\u79cd\u4e9a\u578b\uff0c\u5305\u62ec\u80bf\u7624\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u8102\u80aa\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u548c\u80bf\u7624\u76f8\u5173\u514d\u75ab\u7ec6\u80de\uff08\u5982\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff09\u3002\u5728\u672c\u8282\u4e2d\uff0c\u6211\u4eec\u8be6\u7ec6\u63cf\u8ff0\u4e86\u5df2\u5728\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u7684TME\u4e2d\u88ab\u8868\u5f81\u7684\u4e3b\u8981\u7ec6\u80de\u4e9a\u578b (Fig 36.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n

\n
\n

Fig 36.1 <\/span>\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u6d78\u6da6\u60c5\u51b5\u3002<\/span><\/p>\n

\u5728\u786e\u8bca\u7684\u764c\u75c7\u4e2d\uff0c\u80bf\u7624\u5fae\u73af\u5883\u5305\u542b\u591a\u79cd\u514d\u75ab\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u5171\u540c\u4fc3\u8fdb\u4e86\u6076\u6027\u80bf\u7624\u7684\u751f\u957f\u3002\u80bf\u7624\u4e2d\u6d78\u6da6\u7684\u7ec6\u80de\u65e2\u5305\u62ec\u5148\u5929\u514d\u75ab\u7ec6\u80de\uff0c\u4e5f\u5305\u62ec\u83b7\u5f97\u6027\u514d\u75ab\u7ec6\u80de\uff0c\u5982\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08TAM\uff09\u3001\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u3001\u6dcb\u5df4\u7ec6\u80de\u3001\u80a5\u5927\u7ec6\u80de\u3001\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u3002\u8fd9\u4e9b\u7ec6\u80de\u901a\u8fc7\u534f\u8c03\u5f62\u6210\u4e00\u4e2a\u590d\u6742\u7684\u8c03\u63a7\u7f51\u7edc\uff0c\u8425\u9020\u51fa\u6709\u5229\u4e8e\u764c\u75c7\u9003\u907f\u514d\u75ab\u76d1\u89c6\u548c\u7834\u574f\u7684\u73af\u5883\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\u3002
<\/p>\n

\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u53ca\u53ef\u6eb6\u6027\u56e0\u5b50\u6216\u5177\u6709\u514d\u75ab\u6291\u5236\u7279\u6027\u7684\u9176\uff0c\u5982\u7c92\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08G-CSF\uff09\u3001\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\uff09\u3001\u4e00\u6c27\u5316\u6c2e\uff08NO\uff09\u3001\u6d3b\u6027\u6c27\uff08ROS\uff09\u3001\u524d\u5217\u817a\u7d20E2\uff08PEG2\uff09\u3001\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u9176\uff08IDO\uff09\u3001IL-10\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50\uff08TGF\uff09\u3001\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u548c\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08CTLA-4\uff09\u7b49\uff0c\u5747\u5728\u6b64\u8fc7\u7a0b\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002
<\/p>\n

\u6b64\u5916\uff0c\u67d0\u4e9b\u80bf\u7624\u76f8\u5173\u6297\u539f\uff0c\u5982HER2\/neu\u3001CA-125\u548c\u53f6\u9178\u53d7\u4f53\u03b1\uff08FR\u03b1\uff09\uff0c\u53ef\u4f5c\u4e3a\u4e0d\u540c\u514d\u75ab\u7597\u6cd5\u7684\u9776\u70b9\uff0c\u5305\u62ec\u5355\u514b\u9686\u6297\u4f53\uff08moAb\uff09\u7597\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

36.1.1 \u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de<\/span><\/p>\n

\n
\n
\n

\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08Tumor-Infiltrating Lymphocytes, TILs\uff09\u5e38\u89c1\u4e8e\u5404\u79cd\u80bf\u7624\u4e2d\uff0c\u8868\u660e\u80bf\u7624\u5728\u5bbf\u4e3b\u4f53\u5185\u5f15\u53d1\u4e86\u514d\u75ab\u5e94\u7b54\u3002TILs\u901a\u5e38\u5206\u4e3a\u6d78\u6da6\u80bf\u7624\u764c\u5de2\uff08\u4e0a\u76ae\u5185\uff09\u7684TILs\u548c\u4f4d\u4e8e\u7624\u5468\u95f4\u9699\uff08\u95f4\u8d28\uff09\u7684TILs\u3002\u514d\u75ab\u7cfb\u7edf\uff0c\u5c24\u5176\u662f\u4e0a\u76ae\u5185TILs\uff0c\u88ab\u8ba4\u4e3a\u5728\u51e0\u4e4e\u6240\u6709\u5b9e\u4f53\u7624\u7684\u80bf\u7624\u751f\u957f\u63a7\u5236\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\uff0c\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u4e5f\u4e0d\u4f8b\u5916\u3002<\/p>\n

\u5df2\u6709\u7814\u7a76\u62a5\u9053\u4e86TILs\u53ca\u5176\u514d\u75ab\u57fa\u56e0\u6807\u8bb0\u5728\u4e73\u817a\u764c\u4e2d\u7684\u9884\u540e\u4ef7\u503c\u3002Salgado\u53ca\u5176\u56e2\u961f\u63d0\u51fa\u4e86\u4e00\u79cd\u6807\u51c6\u5316\u7684\u65b9\u6cd5\u6765\u8ba1\u6570TILs\u3002\u5728\u4e0d\u8868\u8fbe\u96cc\u6fc0\u7d20\u53d7\u4f53\u3001\u5b55\u6fc0\u7d20\u53d7\u4f53\u6216HER2\/neu\u57fa\u56e0\u7684\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u4e2d\uff0cTILs\u65e2\u6709\u9884\u540e\u4ef7\u503c\uff0c\u4e5f\u6709\u9884\u6d4b\u4ef7\u503c\u3002\u5728\u8f85\u52a9\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u65e0\u8bba\u662f\u5426\u8fdb\u884c\u6cbb\u7597\uff0cTILs\u7684\u5b58\u5728\u90fd\u4e0e\u66f4\u597d\u7684\u751f\u5b58\u7387\u76f8\u5173\u3002\u4e00\u4e9b\u65b0\u8f85\u52a9\u6cbb\u7597\u7814\u7a76\u53d1\u73b0\uff0c\u514d\u75ab\u7ec6\u80de\u4e30\u5bcc\u7684\u4e73\u817a\u764c\u60a3\u8005\u7684\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff08pCR\uff09\u7387\u663e\u8457\u9ad8\u4e8e\u514d\u75ab\u7ec6\u80de\u532e\u4e4f\u7684\u60a3\u8005\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u63a5\u53d7\u8f85\u52a9\u5316\u7597\u7684\u60a3\u8005\u4e2d\uff0cTILs\u8ba1\u6570\u6bcf\u589e\u52a018%\uff0c\u8fdc\u5904\u590d\u53d1\u7684\u98ce\u9669\u5c31\u4f1a\u964d\u4f4e18%\u3002\u5728HER2\u9633\u6027\u4e73\u817a\u764c\u4e2d\uff0cTILs\u540c\u6837\u4e0e\u8f83\u597d\u7684\u9884\u540e\u76f8\u5173\uff0c\u4f46\u5176\u9884\u6d4b\u4ef7\u503c\u7684\u7ed3\u679c\u8f83\u4e3a\u4e0d\u4e00\u81f4\u3002\u9488\u5bf9\u8154\u5185\u4e73\u817a\u764c\u7684\u7814\u7a76\u8f83\u5c11\uff0c\u4f46\u73b0\u6709\u5c11\u91cf\u6570\u636e\u8868\u660e\uff0cTILs\u53ef\u80fd\u5bf9\u8154\u5185B\u578b\u9ad8\u589e\u6b96\u4e9a\u578b\u7684\u9884\u540e\u5177\u6709\u66f4\u597d\u7684\u9884\u6d4b\u4f5c\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u81ea1991\u5e74\u4ee5\u6765\uff0cTILs\u5bf9\u5375\u5de2\u764c\u60a3\u8005\u751f\u5b58\u76ca\u5904\u7684\u7814\u7a76\u5df2\u7ecf\u5e7f\u6cdb\u5f00\u5c55\u3002\u6700\u8fd1\uff0cHwang\u7b49\u4eba\u8fdb\u884c\u4e86\u4e00\u9879\u835f\u8403\u5206\u6790\uff0c\u65e8\u5728\u8bc4\u4f30TILs\u5728\u5375\u5de2\u764c\u4e2d\u7684\u9884\u540e\u4ef7\u503c\uff0c\u5e76\u7814\u7a76\u5305\u62ec\u80bf\u7624\u7ec4\u7ec7\u5b66\u5728\u5185\u7684\u5176\u4ed6\u5f71\u54cd\u9884\u540e\u7684\u56e0\u7d20\u3002\u4ed6\u4eec\u4f7f\u7528CD3\u6216CD8\u4f5c\u4e3aTILs\u7684\u6807\u8bb0\u7269\uff0c\u7b5b\u9009\u51fa\u4e8610\u9879\u9002\u5408\u7eb3\u5165\u835f\u8403\u5206\u6790\u7684\u7814\u7a76\uff0c\u5171\u5305\u62ec1815\u540d\u53d7\u8bd5\u8005\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0a\u76ae\u5185TILs\u7684\u7f3a\u4e4f\u4e0e\u8f83\u5dee\u7684\u751f\u5b58\u7387\u663e\u8457\u76f8\u5173\uff08\u603b\u4f53\u98ce\u9669\u6bd4\uff1a2.24, 95% CI; 1.71-2.91\uff09\u3002\u56e0\u6b64\uff0c\u4e0a\u76ae\u5185CD8+ TILs\u4f3c\u4e4e\u662f\u5375\u5de2\u764c\u9884\u540e\u7684\u53ef\u9760\u9884\u6d4b\u56e0\u5b50\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

36.1.2 \u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de<\/p>\n<\/section>\n

\n
\n
\n

\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08Cancer-Associated Fibroblasts, CAFs\uff09\u5728\u80bf\u7624\u8fdb\u5c55\u548c\u8010\u836f\u8fc7\u7a0b\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002CAFs\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u751f\u3001\u751f\u957f\u3001\u8840\u7ba1\u751f\u6210\u3001\u4fb5\u88ad\u548c\u8f6c\u79fb\uff0c\u8fd9\u4e9b\u4fc3\u7624\u4f5c\u7528\u4e0e\u5b83\u4eec\u5206\u6ccc\u7684\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u3001\u86cb\u767d\u9176\u3001\u751f\u957f\u56e0\u5b50\u53ca\u5176\u4ed6\u7ec6\u80de\u5916\u57fa\u8d28\u56e0\u5b50\u5bc6\u5207\u76f8\u5173\u3002CAFs\u88ab\u5b9a\u4e49\u4e3a\u6d3b\u5316\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\uff0c\u4e0e\u6b63\u5e38\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u533a\u522b\u5728\u4e8e\u5b83\u4eec\u8868\u8fbe\u4e86\u03b1-\u5e73\u6ed1\u808c\u808c\u52a8\u86cb\u767d\uff08\u03b1-SMA\uff09\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u6d3b\u5316\u86cb\u767d\uff08FAP\uff09\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7279\u5f02\u6027\u86cb\u767d\u548c\u8840\u5c0f\u677f\u884d\u751f\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7b49\u5206\u5b50\u6807\u5fd7\u7269\u3002<\/p>\n

CAFs\u5728\u80bf\u7624\u95f4\u8d28\u4e2d\u53ef\u80fd\u6765\u6e90\u4e8e\u4e94\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\uff1a\u6b63\u5e38\u95f4\u8d28\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u6d3b\u5316\u3001\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u3001\u5468\u7ec6\u80de\u3001\u4e73\u817a\u6216\u5375\u5de2\u4e0a\u76ae\u7ec6\u80de\uff08\u901a\u8fc7\u4e0a\u76ae-\u95f4\u8d28\u8f6c\u5316\uff0cEMT\uff09\u4ee5\u53ca\u5185\u76ae\u7ec6\u80de\uff08\u901a\u8fc7\u5185\u76ae-\u95f4\u8d28\u8f6c\u5316\uff0cEndMT\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u4e0d\u540c\u7684\u6cbb\u7597\u7b56\u7565\u88ab\u63a2\u7d22\u4ee5\u51cf\u5c11\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u4e2d\u7684CAFs\u6570\u91cf\u3002\u4e00\u4e9b\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u8bc4\u4f30\u4e86\u9776\u5411FAP\u7684\u6cbb\u7597\u6548\u679c\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u5355\u72ec\u963b\u65adFAP\u6216\u4e0e\u5316\u7597\u8054\u5408\u4f7f\u7528\u5747\u80fd\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u51cf\u7f13\u80bf\u7624\u751f\u957f\u3002\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86RO6874813\uff08\u4e00\u79cdFAP\u6297\u4f53\uff09\u5728\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u6548\u679c\u3002\u76ee\u524d\u53e6\u4e00\u9879I\u671f\u7814\u7a76\u6b63\u5728\u6d4b\u8bd5RO6874281\uff08\u4e00\u79cd\u7531\u6297FAP\/\u767d\u7ec6\u80de\u4ecb\u7d20-2\u878d\u5408\u86cb\u767d\u7ec4\u6210\u7684\u514d\u75ab\u7ec6\u80de\u56e0\u5b50\uff09\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\u7684\u5e94\u7528\uff0c\u5b83\u901a\u8fc7\u76f4\u63a5\u6291\u5236CAF\u7684\u6d3b\u5316\u8d77\u4f5c\u7528\u3002<\/p>\n

\u6b64\u5916\uff0c\u9488\u5bf9CAFs\u5206\u6ccc\u7684\u56e0\u5b50\u7684\u9776\u5411\u6cbb\u7597\u4e5f\u5728\u591a\u4e2a\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002CAFs\u6bd4\u6b63\u5e38\u6210\u7ea4\u7ef4\u7ec6\u80de\u5206\u6ccc\u66f4\u9ad8\u6c34\u5e73\u7684\u57fa\u8d28\u7ec6\u80de\u884d\u751f\u56e0\u5b501\uff08SDF-1\uff09\uff0c\u8be5\u56e0\u5b50\u4e0e\u764c\u7ec6\u80de\u8868\u9762\u7684CXCR4\u53d7\u4f53\u7ed3\u5408\uff0c\u662f\u4fc3\u8fdb\u4e73\u817a\u80bf\u7624\u8fdb\u5c55\u7684\u5173\u952e\u56e0\u7d20\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0cCXCR4\u6291\u5236\u5242\u80fd\u591f\u5728\u4f53\u5185\u548c\u4f53\u5916\u51cf\u7f13\u4e73\u817a\u80bf\u7624\u7684\u751f\u957f\u3002\u4e00\u9879Ia\/Ib\u671f\u7814\u7a76\u6b63\u5728\u8bc4\u4f30CXCR4\u80bd\u62ee\u6297\u5242LY2510924\u5728\u665a\u671f\u96be\u6cbb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u6548\u679c\uff0c\u5e76\u63a2\u8ba8\u4e86\u5176\u4e0e\u6297PD-L1\u6297\u4f53\u8054\u5408\u4f7f\u7528\u7684\u6f5c\u529b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

36.1.3 \u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de<\/p>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08Tumor-Associated Macrophages, TAMs\uff09\u5728\u80bf\u7624\u8fdb\u5c55\u548c\u8f6c\u79fb\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002TAMs\u901a\u5e38\u5206\u4e3a\u4e24\u79cd\u4e3b\u8981\u7c7b\u578b\uff1a\u4fc3\u708e\u578b\u7684M1\u5de8\u566c\u7ec6\u80de\u548c\u5177\u6709\u514d\u75ab\u6291\u5236\u4f5c\u7528\u7684M2\u5de8\u566c\u7ec6\u80de\u3002\u5728\u4e73\u817a\u764c\u548c\u5375\u5de2\u764c\u4e2d\uff0cTAMs\u4e3b\u8981\u8868\u73b0\u4e3aM2\u5de8\u566c\u7ec6\u80de\u6d78\u6da6\u3002\u591a\u9879\u7814\u7a76\u8868\u660e\uff0c\u5faa\u73af\u4e2d\u7684\u5355\u6838\u7ec6\u80de\u5411M2\u578b\u5de8\u566c\u7ec6\u80de\u7684\u5206\u5316\u4f9d\u8d56\u4e8e\u591a\u79cd\u751f\u957f\u56e0\u5b50\uff0c\u5305\u62ec\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\uff08CSF-1\/MCSF\uff09\u3001\u7c92\u7ec6\u80de-\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b50\uff08GM-CSF\/CSF-2\uff09\u3001\u5de8\u566c\u7ec6\u80de\u523a\u6fc0\u86cb\u767d\uff08MSP\uff09\u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b21\uff08TGF-\u03b21\uff09\u3001\u8d8b\u5316\u56e0\u5b50\u548c\u4fc3\u8840\u7ba1\u751f\u6210\u56e0\u5b50\u3002\u6b64\u5916\uff0cTAMs\u7684\u4fc3\u80bf\u7624\u4f5c\u7528\u4e3b\u8981\u6e90\u4e8e\u5b83\u4eec\u5206\u6ccc\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\uff0c\u8fd9\u4e9b\u56e0\u5b50\u4f1a\u4e0b\u8c03T\u7ec6\u80de\u7684\u6548\u5e94\u529f\u80fd\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9488\u5bf9CSF1\/CSF1R\uff08CSF1\u53d7\u4f53\uff09\u7684\u9776\u5411\u6cbb\u7597\u5df2\u5728\u591a\u9879\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\u5f97\u5230\u8bc4\u4f30\u3002\u7814\u7a76\u8868\u660e\uff0cCSF1\u6216CSF1R\u7684\u836f\u7406\u5b66\u6291\u5236\u6216\u57fa\u56e0\u7f3a\u5931\u53ef\u4ee5\u5728\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u6709\u6548\u6291\u5236\u80bf\u7624\u751f\u957f\u3002\u5728\u8fd9\u4e9b\u6a21\u578b\u4e2d\uff0cCSF1R\u7684\u6291\u5236\u901a\u8fc7\u51cf\u5c11TAMs\u7684\u6570\u91cf\u5e76\u589e\u5f3aCD8+ T\u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u4ece\u800c\u5ef6\u7f13\u4e86\u5bab\u9888\u548c\u4e73\u817a\u80bf\u7624\u7684\u751f\u957f\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u963b\u65adCSF1\/CSF1R\u6216\u5176\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff0c\u80fd\u591f\u51cf\u5c11\u5de8\u566c\u7ec6\u80de\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u6d78\u6da6\uff0c\u589e\u52a0CD8+ T\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u5e76\u8fdb\u4e00\u6b65\u6291\u5236\u4e73\u817a\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n

\u5728\u591a\u79cd\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cCSF1R\u6291\u5236\u5242\u4e0e\u7d2b\u6749\u9187\u8054\u5408\u4f7f\u7528\uff0c\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u751f\u5b58\u7387\uff0c\u8fd8\u964d\u4f4e\u4e86\u8f6c\u79fb\u7684\u98ce\u9669\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u56e0\u6b64\uff0cCSF1\/CSF1R\u963b\u65ad\u5df2\u7ecf\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u5f97\u5230\u4e86\u6d4b\u8bd5\u3002\u5728\u4e00\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0cRO5509554\u901a\u8fc7\u6291\u5236CSF1R\u4e8c\u805a\u5316\uff0c\u5728\u591a\u79cd\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u6210\u529f\u51cf\u5c11\u4e86\u5de8\u566c\u7ec6\u80de\u7684\u6d78\u6da6\uff0c\u5e76\u8bf1\u5bfc\u4e86CD8\/CD4\u6bd4\u503c\u7684\u5347\u9ad8\uff0c\u540c\u65f6\u8868\u73b0\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u8fd9\u79cd\u4eba\u6e90\u5316\u6297huCSF1R IgG1\u5355\u514b\u9686\u6297\u4f53\u80fd\u591f\u963b\u65ad\u914d\u4f53\u4f9d\u8d56\u6027\u548c\u975e\u914d\u4f53\u4f9d\u8d56\u6027\u53d7\u4f53\u7684\u6fc0\u6d3b\u3002<\/p>\n

\u4e09\u9879\u5f00\u653e\u6807\u7b7e\u7684\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86RO5509554\u5728\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u6cbb\u7597\u6d3b\u6027\u3002RO5509554\u65e2\u7528\u4e8e\u5355\u836f\u6cbb\u7597\uff0c\u4e5f\u4e0e\u7d2b\u6749\u9187\u6216\u963f\u66ff\u5229\u73e0\u5355\u6297\uff08\u963b\u65adPD-L1\u7684\u5355\u514b\u9686\u6297\u4f53\uff09\u8054\u5408\u4f7f\u7528\u3002\u53e6\u4e00\u79cdCSF1R\u6291\u5236\u5242LY3022855\u4e5f\u5728\u4e09\u9879\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u5355\u72ec\u6216\u4e0e\u5176\u4ed6\u5206\u5b50\u8054\u5408\u5e94\u7528\u4e8e\u6cbb\u7597\u3002LY3022855\u662f\u4e00\u79cd\u9776\u5411CSF1R\u7684\u4ebaIgG1\u5355\u514b\u9686\u6297\u4f53\uff0c\u5176\u4e2d\u4e24\u9879\u7814\u7a76\u8bc4\u4f30\u4e86\u5176\u5355\u72ec\u5e94\u7528\u4e8e\u665a\u671f\u96be\u6cbb\u6027\u4e73\u817a\u764c\u6216\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u6548\u679c\uff0c\u53e6\u4e00\u9879\u7814\u7a76\u5219\u8bc4\u4f30\u4e86LY3022855\u4e0edurvalumab\u6216tremelimumab\u8054\u5408\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u7684\u7597\u6548\u3002<\/p>\n

\u6b64\u5916\uff0c\u4e00\u9879\u9488\u5bf9CSF-1\u7684II\u671f\u7814\u7a76\u5df2\u7ecf\u542f\u52a8\uff0c\u8fd9\u9879\u968f\u673a\u7814\u7a76\u8bc4\u4f30\u4e86MCS110\uff08\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff09\u4e0e\u5361\u94c2\u548c\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u6cbb\u7597\u665a\u671f\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u7597\u6548\u3002\u53e6\u4e00\u9879Ib\/II\u671f\u7814\u7a76\u6b63\u5728\u8bc4\u4f30MCS110\u4e0ePDR001\uff08\u4e00\u79cd\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff09\u8054\u5408\u6cbb\u7597\u665a\u671f\u6076\u6027\u80bf\u7624\u60a3\u8005\u7684\u6548\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9664\u4e86\u6297\u4f53\u7597\u6cd5\u5916\uff0c\u4e00\u4e9b\u7814\u7a76\u8fd8\u805a\u7126\u4e8eCSF1R\u6fc0\u9176\u6291\u5236\u5242\u3002\u4e24\u9879\u4e00\u671f\u7814\u7a76\u8bc4\u4f30\u4e86\u57f9\u897f\u8fbe\u66ff\u5c3c\u5355\u72ec\u6216\u4e0e\u7d2b\u6749\u9187\u8054\u5408\u7528\u4e8e\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u7597\u6548\u3002\u57f9\u897f\u8fbe\u66ff\u5c3c\u662f\u4e00\u79cd\u53e3\u670d\u9ad8\u6548\u7684\u591a\u9776\u70b9\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u4f5c\u7528\u4e8eCSF1R\u3001Kit\u548cFlt3\u3002\u6b64\u5916\uff0c\u4e00\u9879\u4e00\u671f\u7814\u7a76\u6b63\u5728\u8bc4\u4f30BLZ945\u5355\u72ec\u6216\u4e0ePDR001\u8054\u5408\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u7597\u6548\u3002BLZ945\u662f\u4e00\u79cd\u53e3\u670d\u6709\u6548\u3001\u9009\u62e9\u6027\u5f3a\u7684CSF1R\u6291\u5236\u5242\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u2014 THE  END \u2014<\/span><\/p>\n


<\/p>\n

\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u51bc\u91d1\u6b22<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u59da\u4f69\u8a00 \u9093\u8d8a\u534e<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n

<\/span>
<\/p>\n

\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
\n
\n
\n
\n
<\/strong><\/strong><\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
<\/p>\n

\u53ef\u4ee5\u67e5\u8be22024\u5e74\u6700\u65b0SCI\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\u5566\uff01<\/a>
\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

RCIM\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

<\/span><\/p>\n

\u5173\u6ce8\u672c\u53f7~<\/span>
<\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


<\/p>\n

<\/p>\n

\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


<\/p>\n


<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

<\/mp-style-type><\/p>\n

\n

\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c35\u7ae0 \u524d\u5217\u817a\u764c\u7684\u514d\u75ab\u6cbb\u7597\uff1a\u4e00\u4e2a\u4e0d\u65ad\u53d1\u5c55\u7684\u9886\u57df\uff08\u4e0b\uff09 36.1 \u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u7684\u80bf\u7624\u5fae…<\/p>\n","protected":false},"author":1,"featured_media":3641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3643"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3643"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3643\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3641"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3643"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}