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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c37\u7ae0 \u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u6311\u6218\u4e0e\u5e94\u5bf9\u7b56\u7565\u2014\u2014\u4ece\u75ab\u82d7\u7814\u53d1\u5230\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\uff08\u4e0a\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.9 \u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u9664\u4e86\u514d\u75ab\u7ec6\u80de\u548c\u8c03\u8282\u4fe1\u53f7\u7684\u5b9a\u91cf\u5b58\u5728\u5916\uff0c\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u4e5f\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\uff0c\u5e76\u5177\u6709\u6f5c\u5728\u7684\u6cbb\u7597\u5e72\u9884\u4ef7\u503c\u3002\u8fd9\u4e9b\u5206\u5b50\u5bf9\u5c40\u90e8\u80bf\u7624\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u53ca\u5176\u4ed6\u7ec6\u80de\u7684\u7ec4\u6210\u6709\u7740\u663e\u8457\u7684\u5f71\u54cd\u3002\u9664\u4e86\u7ecf\u5178\u7684\u5e72\u6270\u7d20-\u03b3\u548c\u767d\u7ec6\u80de\u4ecb\u7d20-2\u5916\uff0c\u8fd8\u6709\u4e00\u7cfb\u5217\u86cb\u767d\u8d28\u80fd\u591f\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u7684\u884c\u4e3a\uff0c\u8fdb\u800c\u5bf9\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002\u5728\u8fd9\u4e2a\u590d\u6742\u7684\u73af\u5883\u4e2d\uff0c\u8bb8\u591a\u673a\u5236\u4ecd\u7136\u672a\u5b8c\u5168\u88ab\u7406\u89e3\uff0c\u4f46Wolf H. Friedman\u7814\u7a76\u5c0f\u7ec4\u7684\u5f00\u521b\u6027\u5de5\u4f5c\u5df2\u660e\u786e\u8868\u660e\uff1a\u514d\u75ab\u5b66\u80cc\u666f\u662f\u5173\u952e\u51b3\u5b9a\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n

IL-10\u7684\u4f5c\u7528\u662f\u8fd9\u4e00\u73af\u5883\u4e2d\u4e00\u4e2a\u7279\u522b\u6709\u8da3\u7684\u4f8b\u5b50\u3002IL-10\u7684\u53d1\u73b0\u4ee5\u53ca\u968f\u540e\u7684\u5927\u91cf\u7814\u7a76\u8868\u660e\u4e86\u5176\u5728\u80bf\u7624\u75be\u75c5\u4e2d\u7684\u91cd\u8981\u6027\u3002\u957f\u671f\u4ee5\u6765\uff0cIL-10\u88ab\u666e\u904d\u8ba4\u4e3a\u5177\u6709\u514d\u75ab\u6291\u5236\u529f\u80fd\uff0c\u4ece\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\uff0c\u56e0\u6b64\u5b83\u6210\u4e3a\u4e86\u514d\u75ab\u7cfb\u7edf\u4e2d\u6291\u5236\u6297\u80bf\u7624\u6d3b\u6027\u7684\u4e3b\u8981\u9776\u70b9\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u8fd1\u5e74\u6765\u7684\u7814\u7a76\u663e\u793a\uff0cIL-10\u4e0d\u4ec5\u5177\u6709\u514d\u75ab\u6291\u5236\u529f\u80fd\uff0c\u8fd8\u5177\u5907\u514d\u75ab\u523a\u6fc0\u548c\u514d\u75ab\u805a\u7126\u7684\u80fd\u529b\u3002\u5b8c\u5168\u7f3a\u4e4fIL-10\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8f6c\u79fb\u6269\u6563\u7684\u589e\u5f3a\u4ee5\u53ca\u5176\u4ed6\u4fc3\u80bf\u7624\u4f5c\u7528\u3002\u8fd9\u4e0d\u4ec5\u53cd\u6620\u4e86\u5176\u9ad8\u5ea6\u7684\u73af\u5883\u4f9d\u8d56\u6027\uff0c\u8fd8\u63ed\u793a\u4e86\u708e\u75c7\u7ec6\u80de\u56e0\u5b50\u7684\u529f\u80fd\u5177\u6709\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u8fd9\u79cd\u5242\u91cf\u4f9d\u8d56\u6027\u529f\u80fd\u5728\u5176\u4ed6\u7ec6\u80de\u56e0\u5b50\u7684\u7814\u7a76\u4e2d\u8f83\u96be\u628a\u63e1\uff0c\u4f46\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\u9700\u8981\u66f4\u7efc\u5408\u7684\u5206\u6790\u65b9\u6cd5\u3002<\/p>\n

\u8fd9\u4e9b\u5206\u6790\u5fc5\u987b\u7ed3\u5408\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u7684\u7a7a\u95f4\u5206\u5e03\u548c\u68af\u5ea6\uff0c\u4ee5\u53ca\u80bf\u7624\u7ec6\u80de\u4e0e\u514d\u75ab\u7ec6\u80de\u7684\u5f02\u8d28\u6027\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u590d\u6742\u7684\u529f\u80fd\u5173\u7cfb\u53ef\u80fd\u63ed\u793a\u6f5c\u5728\u6a21\u5f0f\u7684\u5dee\u5f02\u6027\u6548\u5e94\u3002\u4ece\u529f\u80fd\u89d2\u5ea6\u6765\u770b\uff0c\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50\u53ef\u4ee5\u88ab\u5206\u7c7b\u4e3a\u7279\u5b9a\u514d\u75ab\u6fc0\u6d3b\u6a21\u5f0f\u7684\u53cd\u6620\uff0c\u4f8b\u5982TH1\u3001TH2\u548cTH17\u7ec4\u7ec6\u80de\u56e0\u5b50\u3002TH1\u7ec6\u80de\u56e0\u5b50\u7684\u5206\u6ccc\u901a\u5e38\u4e0e\u6548\u5e94T\u7ec6\u80de\u7684\u6fc0\u6d3b\uff08\u5982IL-2\u6c34\u5e73\u7684\u5347\u9ad8\uff09\u76f8\u5173\uff0c\u800cTH2\u73af\u5883\u5219\u4fc3\u4f7f\u6297\u4f53\u751f\u6210\u7684B\u7ec6\u80de\u7684\u6d3b\u5316\u3002TH17\u73af\u5883\u901a\u5e38\u4e0e\u81ea\u8eab\u514d\u75ab\u548c\u03b3-\u03b4 T\u7ec6\u80de\u7684\u6fc0\u6d3b\u6709\u5173\u3002\u5728\u8fd9\u4e9b\u4e0d\u540c\u60c5\u51b5\u4e0b\uff0c\u4e0d\u540c\u7684\u7ec6\u80de\u7fa4\u4f1a\u4ea7\u751f\u7279\u5b9a\u7684\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u7c07\uff0c\u5bf9\u514d\u75ab\u7ec6\u80de\u4e9a\u7fa4\u4ea7\u751f\u4e0d\u540c\u5f71\u54cd\u3002<\/p>\n

\u6709\u4e9b\u7ec6\u80de\u56e0\u5b50\uff0c\u5982\u5de8\u566c\u7ec6\u80de\u8fc1\u79fb\u6291\u5236\u56e0\u5b50\uff08MIF\uff09\uff0c\u5728\u591a\u4e2a\u7cfb\u7edf\u4e2d\uff08\u5982\u8840\u7ba1\u751f\u6210\u3001\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u7b49\uff09\u5177\u6709\u5e7f\u6cdb\u7684\u591a\u6548\u6027\u4f5c\u7528\uff0c\u56e0\u6b64\u96be\u4ee5\u7b80\u5355\u5730\u5f52\u7c7b\u5230\u4e0a\u8ff0\u67d0\u4e00\u7cfb\u7edf\u3002\u8fd9\u8868\u660e\uff0c\u7406\u89e3\u8fd9\u4e9b\u5206\u5b50\u7684\u4f5c\u7528\u9700\u8981\u66f4\u5168\u9762\u7684\u5206\u6790\u548c\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.10 \u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u7b56\u7565<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u4eba\u4eec\u5bf9\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u3001\u80bf\u7624\u7ec6\u80de\u53ca\u5176\u4ed6\u7ec6\u80de\u4e4b\u95f4\u7684\u514d\u75ab\u673a\u5236\u548c\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u89e3\u5df2\u7ecf\u6709\u4e86\u663e\u8457\u8fdb\u5c55\u3002\u5bf9\u8fd9\u4e9b\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u7684\u7814\u7a76\u4ece\u591a\u4e2a\u65b9\u9762\u5f97\u5230\u4e86\u6df1\u5165\u63a2\u8ba8\u3002\u514d\u75ab\u7597\u6cd5\u7684\u4e34\u5e8a\u8fdb\u5c55\u65e0\u7591\u6b63\u5728\u4e3a\u80bf\u7624\u5b66\u5e26\u6765\u9769\u547d\u6027\u7684\u53d8\u5316\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u79d1\u5b66\u8fdb\u5c55\u662f\u5426\u4e5f\u5728\u63a8\u52a8\u7ed3\u76f4\u80a0\u764c\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u53d1\u5c55\u5462\uff1f\u8fd9\u4e2a\u95ee\u9898\u5e76\u4e0d\u5bb9\u6613\u56de\u7b54\u3002<\/p>\n

\u5bf9\u4e8e\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u4e9a\u7fa4\uff0c\u514d\u75ab\u6cbb\u7597\u5df2\u7ecf\u663e\u793a\u51fa\u660e\u663e\u7684\u7597\u6548\u3002\u4f46\u5bf9\u4e8e\u5176\u4ed6\u4e9a\u7fa4\u800c\u8a00\uff0c\u5c3d\u7ba1\u5df2\u7ecf\u8fdb\u884c\u4e86\u591a\u79cd\u514d\u75ab\u5e72\u9884\u5c1d\u8bd5\uff0c\u7ed3\u76f4\u80a0\u764c\u4f9d\u7136\u662f\u4e00\u4e2a\u6781\u5177\u6311\u6218\u6027\u7684\u514d\u75ab\u6cbb\u7597\u5bf9\u8c61\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u6709\u4e00\u4e9b\u4ee4\u4eba\u9f13\u821e\u7684\u62a5\u544a\u663e\u793a\uff0c\u65e0\u8bba\u5fae\u536b\u661f\u7a33\u5b9a\u6027\u6216BRAF\u7a81\u53d8\u72b6\u6001\u5982\u4f55\uff0c\u514d\u75ab\u6cbb\u7597\u5728\u665a\u671f\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u4ecd\u7136\u53d6\u5f97\u4e86\u4e34\u5e8a\u6548\u679c\u3002\u8fd9\u4e3a\u672a\u6765\u7684\u6cbb\u7597\u7b56\u7565\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.11 \u75ab\u82d7\u63a5\u79cd\u4e0e\u6811\u7a81\u72b6\u7ec6\u80de\u6cbb\u7597\uff1a\u91cd\u5851\u514d\u75ab\u7cfb\u7edf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4ece\u5386\u53f2\u89d2\u5ea6\u6765\u770b\uff0c\u75ab\u82d7\u63a5\u79cd\u5df2\u5e7f\u6cdb\u7528\u4e8e\u5404\u79cd\u764c\u75c7\u7c7b\u578b\u7684\u6cbb\u7597\uff08\u89c1Fig 37.3<\/span>\uff09\u30022006\u5e74\u5bf9\u7ed3\u76f4\u80a0\u764c\u75ab\u82d7\u63a5\u79cd\u7b56\u7565\u7684\u603b\u7ed3\u663e\u793a\u51fa\u4ee4\u4eba\u6df1\u601d\u7684\u7ed3\u679c\u3002Nagorsen\u548cThiel\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728\u5bf9527\u540d\u60a3\u8005\u8fdb\u884c\u591a\u79cd\u7279\u5b9a\u4e3b\u52a8\u514d\u75ab\u7b56\u7565\u7684\u5206\u6790\u4e2d\uff0c\u603b\u4f53\u5e94\u7b54\u7387\u4ec5\u4e3a0.9%\u3002\u5927\u7ea6\u4e00\u534a\u7684\u60a3\u8005\u8868\u73b0\u51fa\u4f53\u6db2\u514d\u75ab\u548c\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\u3002\u5176\u4ed6\u7b56\u7565\u4e5f\u8fdb\u884c\u4e86\u5c1d\u8bd5\uff0c\u4f8b\u5982\u5c06\u5316\u5b66\u514d\u75ab\u7597\u6cd5\u4e0e\u75ab\u82d7\u63a5\u79cd\u76f8\u7ed3\u5408\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 37.3 <\/span>\u7ed3\u76f4\u80a0\u764c\u7684\u75ab\u82d7\u63a5\u79cd\u7b56\u7565<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5c3d\u7ba1\u8fd9\u79cd\u7ed3\u5408\u65b9\u6cd5\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u663e\u793a\u51fa\u4e34\u5e8a\u6548\u679c\uff0c\u4f46\u5c1a\u4e0d\u6e05\u695a\u662f\u5316\u5b66\u514d\u75ab\u7597\u6cd5\u8fd8\u662f\u75ab\u82d7\u63a5\u79cd\u4ea7\u751f\u4e86\u4f5c\u7528\u3002\u5feb\u901f\u6210\u719f\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u764c\u80da\u6297\u539f\u75ab\u82d7\u5728\u8c03\u8282\u514d\u75ab\u7cfb\u7edf\u65b9\u9762\u6ca1\u6709\u8868\u73b0\u51fa\u663e\u8457\u7684\u4e34\u5e8a\u6548\u679c\u3002\u5728\u4e00\u9879\u9488\u5bf950\u540d\u60a3\u8005\u7684\u7814\u7a76\u4e2d\uff0c\u809d\u8f6c\u79fb\u7076\u5207\u9664\u540e\u5c1d\u8bd5\u5229\u7528\u65b0\u57ce\u75ab\u75c5\u6bd2\u4fee\u9970\u7684\u80bf\u7624\u7ec6\u80de\u8fdb\u884c\u8f85\u52a9\u514d\u75ab\uff0c\u4f46\u540c\u6837\u6ca1\u6709\u89c2\u5bdf\u5230\u660e\u786e\u7684\u4e34\u5e8a\u76ca\u5904\u3002\u5728\u764c\u75c7\u548c\u767d\u8840\u75c5B\u7ec4\u7814\u7a76\u4e2d\uff0c\u6297\u72ec\u7279\u578b\u5355\u514b\u9686\u6297\u4f53\u75ab\u82d7\u88ab\u7528\u4e8e50\u540d\u6839\u6cbb\u6027\u5207\u9664\u540e\u7684\u60a3\u8005\uff0c\u4f462\u5e74\u540e\u7684\u8bc4\u4f30\u663e\u793a\uff0c\u63a5\u79cd\u7ec4\u5e76\u672a\u83b7\u76ca\u3002<\/p>\n

\u5728\u4e00\u9879\u968f\u673aII\u671f\u8bd5\u9a8c\u4e2d\uff0c\u6bd4\u8f83\u4e86\u4f7f\u7528\u7f16\u7801CEA\u548cMUC1\u7684\u75d8\u82d7\u75c5\u6bd2\u8f7d\u4f53\u4fee\u9970\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u4e0e\u76f8\u540c\u65b9\u6848\u52a0GM-CSF\u5728\u5207\u9664\u540e\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u6548\u679c\uff0c\u7ed3\u679c\u663e\u793a\u51fa\u4e00\u4e9b\u5e0c\u671b\u3002\u6811\u7a81\u72b6\u7ec6\u80de\u75ab\u82d7\u548c\u75d8\u82d7\u75c5\u6bd2\u8f7d\u4f53\u75ab\u82d7\u7684\u63a5\u79cd\u5747\u4f7f\u60a3\u8005\u5b58\u6d3b\u65f6\u95f4\u5ef6\u957f\u3002\u5c3d\u7ba1\u968f\u540e\u63d0\u51fa\u4e86\u8fdb\u4e00\u6b65\u7684\u968f\u673a\u8bd5\u9a8c\u8ba1\u5212\uff0c\u4f46\u76ee\u524d\u5c1a\u65e0\u53ef\u7528\u6570\u636e\u3002<\/p>\n

\u5bf9\u7ed3\u76f4\u80a0\u764c\u75ab\u82d7\u63a5\u79cd\u7684\u7814\u7a76\u5174\u8da3\u4ecd\u7136\u5f3a\u70c8\uff0c\u5e76\u4e14\u4e0d\u65ad\u5c1d\u8bd5\u901a\u8fc7\u4e0d\u540c\u7684\u4f50\u5242\u6765\u589e\u5f3a\u514d\u75ab\u7ec6\u80de\u7684\u6fc0\u6d3b\u4f5c\u7528\uff08Garbitsch\u7b49\u4eba\uff0cJCO 32:5 s 2014, \u6458\u89813093\uff09\u3002\u867d\u7136\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6cbb\u7597\u65b9\u6cd5\u79cd\u7c7b\u7e41\u591a\uff0c\u4f46\u603b\u4f53\u800c\u8a00\uff0c\u4ec5\u5728\u8f85\u52a9\u6cbb\u7597\u7684\u60c5\u51b5\u4e0b\uff0c\u75ab\u82d7\u63a5\u79cd\u663e\u793a\u51fa\u4e86\u4e00\u4e9b\u663e\u8457\u6548\u679c\uff0c\u4f46\u5c1a\u65e0\u5927\u578b\u8bd5\u9a8c\u8bc1\u5b9e\u3002\u800c\u5bf9\u4e8e\u665a\u671f\u75be\u75c5\uff0c\u7ed3\u679c\u5374\u4ee4\u4eba\u5931\u671b\u3002<\/p>\n

Stimuvax\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u8bd5\u9a8c\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u4f46\u5728\u80ba\u764c\u4e2d\u7684\u8bd5\u9a8c\u672a\u663e\u793a\u51fa\u4e34\u5e8a\u6548\u679c\u3002\u9884\u8ba1\u52302018\u5e74\uff0c\u5c06\u63ed\u6653\u7ed3\u76f4\u80a0\u764c\u7814\u7a76\u7684\u7ed3\u679c\u3002\u76f8\u6bd4\u201c\u73b0\u6210\u7684\u201d\u75ab\u82d7\uff0c\u4e2a\u4f53\u5316\u75ab\u82d7\u4f3c\u4e4e\u662f\u4e00\u4e2a\u66f4\u6709\u524d\u666f\u7684\u65b0\u65b9\u5411\uff0c\u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6709\u671b\u5f88\u5feb\u542f\u52a8\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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37.12 \u7ec6\u80de\u56e0\u5b50\u7684\u6cbb\u7597\u5e94\u7528<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u7ec6\u80de\u56e0\u5b50\u7684\u514d\u75ab\u8c03\u8282\u663e\u793a\u51fa\u4e86\u4e00\u4e9b\u6709\u8da3\u7684\u7ed3\u679c\u3002\u5728\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5316\u7597\u514d\u75ab\u6cbb\u7597\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u548cFOLFOX-4\u65b9\u6848\uff0c\u968f\u540e\u76ae\u4e0b\u6ce8\u5c04GM-CSF\u548cIL-2\uff08GOLFIG\uff09\uff0c\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u6cbb\u7597\u6d3b\u6027\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5bf9\u7167\u7ec4\u62db\u52df\u95ee\u9898\uff0c\u6700\u7ec8\u8bd5\u9a8c\u7684\u6570\u636e\u5b58\u5728\u4e0d\u786e\u5b9a\u6027\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u4e00\u7cfb\u5217\u8bd5\u9a8c\u7684\u6570\u636e\u8868\u660e\u8be5\u65b9\u6848\u5177\u6709\u5ba2\u89c2\u7684\u7597\u6548\u3002<\/p>\n

\u6b64\u5916\uff0c\u8fd9\u79cd\u7ec4\u5408\u65b9\u6cd5\u8fd8\u5728\u540c\u65f6\u63a5\u79cd\u75ab\u82d7\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u4f7f\u7528\u4e86\u9776\u5411\u80f8\u82f7\u9178\u5408\u6210\u9176\uff08TSPP\uff09\u7684\u591a\u8868\u4f4d\u80bd\u75ab\u82d7\u3002\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u6ce8\u5c04\u90e8\u4f4d\u80bf\u80c0\u548c\u7ea2\u6591\uff0817\u4f8b\uff09\u3001I-II\u7ea7\u8840\u6db2\u5b66\u6539\u53d8\uff0816\u4f8b\uff09\u4ee5\u53ca\u80c3\u80a0\u9053\u4e8b\u4ef6\uff0812\u4f8b\uff09\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8be5\u65b9\u6848\u8fd8\u5f15\u53d1\u4e86\u4e00\u4e9b\u5168\u8eab\u6027\u53cd\u5e94\uff0c\u5305\u62ec\u53d1\u70ed\u3001\u9f3b\u708e\u3001\u7ed3\u819c\u708e\u3001\u591a\u5173\u8282\u75db\u4ee5\u53ca\u81ea\u8eab\u6297\u4f53\u5347\u9ad8\uff0c\u5982ANA\u3001ENA\u3001c-ANCA\u548cp-ANCA\u3002<\/p>\n

\u76ee\u524d\uff0c\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u8bc4\u4f30\u6b63\u5728\u8ba1\u5212\u4e2d\uff0c\u4ee5\u66f4\u5168\u9762\u5730\u4e86\u89e3\u8be5\u65b9\u6848\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.13 \u8fc7\u7ee7T\u7ec6\u80de\u7597\u6cd5\u548c\u8f6c\u57fa\u56e0T\u7ec6\u80de\u7597\u6cd5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fc7\u7ee7\u6027T\u7ec6\u80de\u6cbb\u7597\u662f\u7ed3\u76f4\u80a0\u764c\u7814\u7a76\u7684\u4e00\u4e2a\u91cd\u8981\u9886\u57df\uff0c\u5728\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7684\u6cbb\u7597\u4e2d\u5df2\u53d6\u5f97\u4e86\u663e\u8457\u6548\u679c\uff0c\u5982Fig 37.4<\/span>\u6240\u793a\u3002\u7136\u800c\uff0c\u8fc7\u7ee7\u6027T\u7ec6\u80de\u7597\u6cd5\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u5e94\u7528\u5374\u5927\u591a\u4e0d\u5c3d\u5982\u4eba\u610f\u3002\u4e00\u9879\u9488\u5bf9\u809d\u8f6c\u79fb\u764c\u6839\u6cbb\u6027\u5207\u9664\u540e\u7684\u8f85\u52a9\u8bd5\u9a8c\u4e2d\uff0c\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u52a0IL-2\u6cbb\u7597\u57285\u5e74\u968f\u8bbf\u5206\u6790\u4e2d\u663e\u793a\u51fa\u4ee4\u4eba\u5931\u671b\u7684\u7ed3\u679c\u3002\u8fd9\u79cd\u65b9\u6cd5\u56e0\u6b64\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u88ab\u5f03\u7528\u3002
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 37.4 <\/span>\u8fc7\u7ee7\u514d\u75ab\u6cbb\u7597\u793a\u610f\u56fe<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u79cd\u6cbb\u7597\u7b56\u7565\u662f\u5229\u7528\u8f6c\u57fa\u56e0\u6280\u672f\u4fee\u9970T\u7ec6\u80de\u53d7\u4f53\u4ee5\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\u3002\u5c3d\u7ba1\u5728\u6076\u6027\u8840\u6db2\u75c5\u4e2d\u53d6\u5f97\u4e86\u663e\u8457\u6210\u529f\uff0c\u4f46\u8fd9\u4e00\u65b9\u6cd5\u5c1a\u672a\u5728\u5b9e\u4f53\u7624\u4e2d\u5f97\u5230\u590d\u5236\uff0c\u7279\u522b\u662f\u5728\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u4e2d\u3002\u901a\u8fc7\u57fa\u56e0\u4fee\u9970T\u7ec6\u80de\u4ee5\u8d4b\u4e88\u5176\u7279\u5f02\u6027T\u7ec6\u80de\u53d7\u4f53\u662f\u4e00\u79cd\u5de7\u5999\u7684\u65b9\u6cd5\uff0c\u4f46\u8fd9\u4e9b\u4fee\u9970\u7684T\u7ec6\u80de\u4f3c\u4e4e\u5728\u7ed3\u76f4\u80a0\u764c\u7684\u5fae\u73af\u5883\u4e2d\u5bb9\u6613\u53d7\u5230\u5176\u4ed6\u9003\u9038\u673a\u5236\u7684\u6291\u5236\u3002\u6b64\u5916\uff0c\u7ed3\u76f4\u80a0\u764c\u9762\u4e34\u7684\u53e6\u4e00\u4e2a\u6311\u6218\u662f\u9776\u70b9\u7684\u7279\u5f02\u6027\u95ee\u9898\u3002CEA\uff08\u764c\u80da\u6297\u539f\uff09\u5728\u5176\u4ed6\u7ec6\u80de\u4e2d\u4e5f\u6709\u8868\u8fbe\uff0c\u5bfc\u81f4\u4e86\u5927\u91cf\u4e0d\u5fc5\u8981\u7684\u4e25\u91cd\u526f\u4f5c\u7528\uff0c\u5176\u4e2d\u4e4b\u4e00\u662f\u4e25\u91cd\u7684\u77ed\u6682\u6027\u7ed3\u80a0\u708e\u3002\u5c3d\u7ba1\u5728\u67d0\u4e9b\u75c5\u4f8b\u4e2d\u89c2\u5bdf\u5230\u8f6c\u79fb\u6027\u764c\u75c7\u7684\u5ba2\u89c2\u56de\u5f52\uff0c\u4f46\u8fd9\u4e9b\u7597\u6cd5\u5f15\u53d1\u7684\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u9650\u5236\u4e86\u5176\u5e94\u7528\u3002<\/p>\n

\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u627e\u5230\u66f4\u5408\u9002\u7684\u9776\u70b9\u548c\u66f4\u6709\u6548\u7684\u673a\u5236\uff0c\u4ee5\u66f4\u597d\u5730\u63a7\u5236\u4fee\u9970\u540e\u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09T\u7ec6\u80de\uff0c\u4ece\u800c\u4e3a\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u5e26\u6765\u65b0\u7684\u673a\u4f1a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.14 \u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u68c0\u67e5\u70b9\u6291\u5236\u6cbb\u7597<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI\uff09\u7684\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u514d\u75ab\u8c03\u8282\u4e0e\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u53d6\u5f97\u4e86\u663e\u8457\u6210\u529f\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u7edd\u5927\u591a\u6570\u5fae\u536b\u661f\u7a33\u5b9a\u6027\uff08MSS\uff09\u7684\u60a3\u8005\uff0c\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u8fc4\u4eca\u672a\u80fd\u53d6\u5f97\u663e\u8457\u6548\u679c\u3002\u867d\u7136MSI\u80bf\u7624\u603b\u4f53\u4e0a\u663e\u793a\u51fa\u826f\u597d\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u5e76\u5728\u4e0d\u540c\u7c7b\u578b\u7684\u764c\u75c7\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u6548\u679c\uff0c\u4f46\u5728MSS\u7ed3\u76f4\u80a0\u764c\u4e2d\uff0c\u6297PD-1\u3001\u6297PD-L1\u6216\u6297CTLA-4\u7684\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u5c1a\u672a\u663e\u793a\u51fa\u7597\u6548\u3002<\/p>\n

CheckMate 142\u8bd5\u9a8c\u4e2d\uff0c\u8054\u5408\u4f7f\u7528\u6297PD-1\uff08nivolumab\uff09\u548c\u6297CTLA-4\uff08ipilimumab\uff09\u7684\u6cbb\u7597\u663e\u793a\u51fa\u5bf9\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u75c7\u72b6\u7684\u6291\u5236\u4f5c\u7528\u3002\u6b63\u5982\u9884\u671f\u7684\u90a3\u6837\uff0c\u8fd9\u4e00\u7597\u6cd5\u5bf9MSI\u80bf\u7624\u60a3\u8005\u8868\u73b0\u51fa\u826f\u597d\u7684\u53cd\u5e94\uff0c\u800cMSS\u80bf\u7624\u60a3\u8005\u5219\u672a\u89c1\u660e\u663e\u5e94\u7b54\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u65e9\u671fI\u671f\u8bd5\u9a8c\u4e2d\uff0c\u6297PD-L1\u4e0e\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff08\u5982MEK\u6291\u5236\u5242\uff09\u7684\u7ec4\u5408\u663e\u793a\u51fa\u6709\u5e0c\u671b\u7684\u7ed3\u679c\uff08\u89c1Fig 37.5<\/span>\uff09\u3002\u5728\u62a5\u544a\u768423\u540d\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08\u5176\u4e2d22\u540d\u4e3aKRAS\u7a81\u53d8\u4f53\uff0c1\u540d\u4e3a\u91ce\u751f\u578b\uff09\u4e2d\uff0c\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u76f8\u5173\u526f\u4f5c\u7528\u5305\u62ec\u8179\u6cfb\uff0869.6%\uff09\u3001\u75b2\u52b3\uff0852.2%\uff09\u3001\u75e4\u75ae\u6837\u76ae\u708e\uff0843.5%\uff09\u3001\u76ae\u75b9\uff0834.8%\uff09\u3001\u6591\u4e18\u75b9\uff0826.1%\uff09\u3001\u7619\u75d2\uff0826.1%\uff09\u548c\u6076\u5fc3\uff0826.1%\uff09\u3002III\u7ea7\u548cIV\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u7684\u53d1\u751f\u7387\u4e3a34.8%\uff0c\u5176\u4e2d\u8d85\u8fc7\u4e24\u540d\u60a3\u8005\u51fa\u73b0\u4e86\u4e25\u91cd\u7684\u8179\u6cfb\uff088.7%\uff09\u3002\u7136\u800c\uff0c\u6ca1\u6709\u62a5\u544aV\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u3002\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a17%\uff0c\u5176\u4e2d4\u4f8b\u90e8\u5206\u7f13\u89e3\uff0c5\u4f8b\u75c5\u60c5\u7a33\u5b9a\u3002\u6709\u8da3\u7684\u662f\uff0c\u62a5\u544a\u7684\u4e09\u4e2a\u53cd\u5e94\u4ecd\u5728\u6301\u7eed\uff08\u622a\u81f3\u6570\u636e\u622a\u6b62\u65f6\u4e3a4.0-7.7\u4e2a\u6708\uff09\u3002\u7531\u4e8e\u8be5\u8bd5\u9a8c\u9488\u5bf9\u7684\u662fMSS\u578b\u60a3\u8005\uff0c\u4e09\u540d\u5e94\u7b54\u8005\u4e3a\u9519\u914d\u4fee\u590d\u529f\u80fd\u6b63\u5e38\u8005\uff0c\u4e00\u540d\u60a3\u8005\u7684\u72b6\u6001\u672a\u77e5\u3002\u4e0e\u9884\u671f\u76f8\u53cd\uff0c\u53cd\u5e94\u4e0e\u57fa\u7ebfPD-L1\u8868\u8fbe\u65e0\u5173\u3002<\/p>\n

\u4e3a\u4e86\u66f4\u597d\u5730\u7406\u89e3\u6cbb\u7597\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f71\u54cd\uff0c\u7814\u7a76\u8005\u8fdb\u884c\u4e86\u7cfb\u5217\u6d3b\u68c0\uff0c\u7ed3\u679c\u663e\u793a\u6cbb\u7597\u4e0ePD-L1\u4e0a\u8c03\u3001CD8 T\u7ec6\u80de\u6d78\u6da6\u4ee5\u53caMHC I\u7c7b\u5206\u5b50\u8868\u8fbe\u589e\u5f3a\u6709\u5173\u3002\u8fd9\u4e00\u53d1\u73b0\u4e0e\u5148\u524d\u7684\u89c2\u5bdf\u76f8\u7b26\uff0c\u5373MEK\u6291\u5236\u5242\u5bf9T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u529f\u80fd\u7684\u6291\u5236\u6548\u679c\u5728\u5b58\u5728PD-L1\/PD-1\u9014\u5f84\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u5728\u4f53\u5185\u88ab\u90e8\u5206\u514b\u670d\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cMEK\u6291\u5236\u5242\u8054\u5408PD-L1\u963b\u65ad\u80fd\u591f\u589e\u5f3a\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u662f\u901a\u8fc7\u6291\u5236MEK\u4e0a\u8c03\u80bf\u7624MHC I\u7c7b\u5206\u5b50\u7684\u8868\u8fbe\u800c\u5b9e\u73b0\u7684\u3002\u8fd9\u4e00\u6cbb\u7597\u6982\u5ff5\u76ee\u524d\u6b63\u5728\u4e00\u9879III\u671f\u8bd5\u9a8c\uff08NCT02788279\uff09\u4e2d\u8fdb\u884c\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 37.5<\/span> MEK\u6291\u5236\u548c\u6297PD- L1\u8054\u5408\u6cbb\u7597\u5728\u5fae\u73af\u5883\u4e2d\u7684\u6548\u679c<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.15 \u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u8c03\u8282<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u4f20\u7edf\u6fc0\u6d3b\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u514d\u75ab\u7597\u6cd5\u4e0d\u540c\uff0c\u4e00\u79cd\u65b0\u5174\u7684\u7597\u6cd5\u2014\u2014\u5de8\u566c\u7ec6\u80de\u8c03\u8282\uff08MOMA\uff09\u7597\u6cd5\uff0c\u65e8\u5728\u8c03\u63a7\u5148\u5929\u514d\u75ab\u7ec6\u80de\u3002\u8fd9\u79cd\u7597\u6cd5\u901a\u8fc7\u8c03\u52a8\u514d\u75ab\u7cfb\u7edf\u7684\u5148\u5929\u90e8\u5206\u6765\u5bf9\u6297\u80bf\u7624\uff0c\u4e0e\u53cc\u81a6\u9178\u76d0\u6216\u6d88\u8017\u6297\u4f53\uff08\u5982\u6297CSF-1R\uff09\u7b49\u6d88\u8017\u6027\u65b9\u6cd5\u5f62\u6210\u5bf9\u6bd4\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u8fd9\u4e00\u9886\u57df\uff0c\u4e00\u79cd\u6f5c\u5728\u7684\u6cbb\u7597\u7b56\u7565\u662f\u6291\u5236CD47-SIRP\u03b1\u76f8\u4e92\u4f5c\u7528\u3002CD47\u662f\u4e00\u79cd\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7684\u201c\u4e0d\u8981\u5403\u6211\u201d\u4fe1\u53f7\uff0c\u901a\u8fc7\u4e0e\u5de8\u566c\u7ec6\u80de\u4e0a\u7684SIRP\u03b1\u76f8\u4e92\u4f5c\u7528\u6765\u6291\u5236\u541e\u566c\u4f5c\u7528\u3002\u6700\u521d\u7684\u7814\u7a76\u663e\u793a\uff0c\u8fd9\u4e00\u7b56\u7565\u5728\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e2d\u8868\u73b0\u51fa\u826f\u597d\u7684\u6548\u679c\uff0c\u5e76\u4e14\u5bf9\u5b9e\u4f53\u80bf\u7624\u4e5f\u5177\u6709\u6f5c\u529b\u3002\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u5f00\u59cb\u8bc4\u4f30\u8fd9\u4e00\u6982\u5ff5\uff08\u5982NCT02367196\u3001NCT02678338\u548cNCT02890368\uff09\uff0c\u4f46\u7ed3\u679c\u5c1a\u5f85\u516c\u5e03\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u4e8e\u5bf9\u8f6c\u79fb\u6027\u764c\u75c7\u5fae\u73af\u5883\u7684\u5206\u6790\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u66ff\u4ee3\u7597\u6cd5\uff0c\u5e76\u6210\u529f\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002\u8fd9\u4e00\u7597\u6cd5\u901a\u8fc7\u6291\u5236CCL5-CCR5\u8f74\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u809d\u810f\u75c5\u53d8\u4e2d\u7684\u4f5c\u7528\uff08\u89c1Fig 37.6<\/span>\uff09\uff0c\u5728I\u671f\u8bd5\u9a8c\uff08NCT01736813\uff09\u4e2d\u4f7f\u7528\u4e86\u4e34\u5e8a\u53ef\u7528\u7684CCR5\u6291\u5236\u5242Maraviroc\u3002CCR5\u6291\u5236\u5242\u901a\u8fc7\u590d\u6781\u5316\u5de8\u566c\u7ec6\u80de\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u7684\u5148\u5929\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u526f\u4f5c\u7528\u8f83\u5c0f\uff0c\u5e76\u5728\u4e00\u5c0f\u90e8\u5206\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u4e0e\u5316\u7597\u7684\u534f\u540c\u6548\u679c\u3002<\/p>\n

\u5728\u8be5\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u4e2d\u5b58\u5728BRAF\u7a81\u53d8\uff087.14%\uff09\u6216KRAS\u7a81\u53d8\uff0857.14%\uff09\uff0c\u5176\u4e2d\u4e00\u4e9b\u60a3\u8005\u5df2\u7ecf\u63a5\u53d7\u4e86\u591a\u8fbe\u516d\u79cd\u6cbb\u7597\u65b9\u6cd5\uff0c\u5305\u62ec\u96f7\u6208\u975e\u5c3c\u6cbb\u7597\uff0828.57%\uff09\u3002\u603b\u4f53\u800c\u8a00\uff0c\u526f\u4f5c\u7528\u6709\u9650\uff0c\u5927\u591a\u6570\u4e3aI\u7ea7\u548cII\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff0889.33%\uff09\uff0cIII\u7ea7\u548cIV\u7ea7\u4e8b\u4ef6\u8f83\u5c11\uff0810.77%\uff09\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u5b9e\u9a8c\u5ba4\u503c\u504f\u5dee\uff0c\u5982\u03b3-\u8c37\u6c28\u9170\u8f6c\u79fb\u9176\u5347\u9ad8\u3002\u4e34\u5e8a\u89c2\u5bdf\u4e2d\uff0c\u5f71\u50cf\u5b66\u5206\u6790\u663e\u793a\u8f6c\u79fb\u6027\u75c5\u53d8\u7684\u574f\u6b7b\u589e\u52a0\uff0c\u5e76\u901a\u8fc7\u6d3b\u68c0\u7ec4\u7ec7\u5b66\u5206\u6790\u5f97\u5230\u8bc1\u5b9e\u3002\u8fde\u7eed\u6d3b\u68c0\u8fd8\u663e\u793a\uff0c\u6cbb\u7597\u540e\u809d\u8f6c\u79fb\u7076\u7684\u6d78\u6da6\u8fb9\u7f18\u51fa\u73b0\u4e86\u7a33\u5b9a\u7684T\u7ec6\u80de\u6d78\u6da6\u3002<\/p>\n

\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u60a3\u8005\u88ab\u5141\u8bb8\u5c06CCR5\u6291\u5236\u5242\u4e0e\u5148\u524d\u4e0d\u6210\u529f\u7684\u5316\u7597\u8054\u5408\u4f7f\u7528\u3002\u5176\u57fa\u672c\u539f\u7406\u662f\u5047\u8bbe\u9aa8\u9ad3\u7ec6\u80de\u4ea7\u751f\u7684\u5e72\u6270\u7d20\u4f1a\u589e\u5f3a\u5316\u7597\u6548\u679c\u3002\u57285\u4f8b\u60a3\u8005\u4e2d\uff0c3\u4f8b\u51fa\u73b0\u4e86\u8054\u5408\u6cbb\u7597\u7684\u5ba2\u89c2\u53cd\u5e94\uff081\u4f8b\u65e0\u6cd5\u8bc4\u4f30\uff09\uff0c\u80bf\u7624\u63a7\u5236\u7387\u8fbe\u523080%\u3002<\/p>\n

\u7531\u6b64\u53ef\u89c1\uff0c\u5c06\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u6fc0\u6d3b\u4e0e\u5176\u4ed6\u514d\u75ab\u8c03\u8282\u65b9\u6cd5\u76f8\u7ed3\u5408\u5177\u6709\u826f\u597d\u7684\u524d\u666f\uff0c\u8fd9\u4e00\u6982\u5ff5\u76ee\u524d\u6b63\u5728\u8fdb\u4e00\u6b65\u7684\u8bd5\u9a8c\u4e2d\u6df1\u5165\u7814\u7a76\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 37.6 <\/span>\u6291\u5236CCR5\u5bf9\u5927\u80a0\u764c\u5de8\u566c\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u7684\u5f71\u54cd\u793a\u610f\u56fe<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.16 \u603b\u7ed3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ed3\u76f4\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597\u4e00\u76f4\u9762\u4e34\u6311\u6218\uff0c\u76f4\u5230\u6700\u8fd1\uff0c\u7597\u6548\u5927\u591a\u4e0d\u663e\u8457\u751a\u81f3\u65e0\u6548\u3002\u7136\u800c\uff0c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI\uff09\u80bf\u7624\u60a3\u8005\u7684\u524d\u666f\u4ee4\u4eba\u632f\u594b\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u80bf\u7624\u5bf9\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8868\u73b0\u51fa\u6781\u9ad8\u7684\u5e94\u7b54\u7387\u3002\u76ee\u524d\uff0c\u7ec4\u5408\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u6b63\u5728\u8fd9\u4e00\u7279\u5b9a\u4e9a\u7ec4\u60a3\u8005\u4e2d\u8fdb\u884c\u6d4b\u8bd5\uff0c\u7ed3\u679c\u975e\u5e38\u9f13\u821e\u4eba\u5fc3\u3002<\/p>\n

\u5bf9\u4e8e\u5927\u591a\u6570\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u80bf\u7624\u60a3\u8005\uff0c\u60c5\u51b5\u4e5f\u5728\u9010\u6b65\u6539\u5584\u3002\u5c3d\u7ba1KRAS\u3001BRAF\u548cPI3K\u7a81\u53d8\u65e0\u5173\u7684\u6cbb\u7597\u65b9\u6848\u5c1a\u5728\u7814\u7a76\u4e2d\uff0c\u4f46\u514d\u75ab\u6cbb\u7597\u4f9d\u7136\u663e\u793a\u51fa\u663e\u8457\u7684\u53cd\u5e94\u7387\u3002\u5c3d\u7ba1\u76ee\u524d\u4e3a\u6b62\uff0c\u68c0\u67e5\u70b9\u6291\u5236\u5728MSS\u60a3\u8005\u4e2d\u7684\u6570\u636e\u5c1a\u672a\u4ee4\u4eba\u4fe1\u670d\uff0c\u4f46\u901a\u8fc7\u7ed3\u5408\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u548c\u9002\u5e94\u6027\u514d\u75ab\u7cfb\u7edf\u6765\u6539\u9020\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5df2\u5c55\u73b0\u51fa\u65b0\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u8fd9\u4e00\u8d8b\u52bf\u4e3a\u672a\u6765\u6cbb\u7597\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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37.17 \u5c55\u671b\u548c\u672a\u6765\u65b9\u5411<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u66fe\u4e16\u7eaa<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u59da\u4f69\u8a00 \u675c\u8f7b\u677e<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c37\u7ae0 \u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u6311\u6218\u4e0e\u5e94\u5bf9\u7b56\u7565\u2014\u2014\u4ece\u75ab\u82d7\u7814\u53d1\u5230\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\uff08\u4e0a\uff09 37.9 \u5fae…<\/p>\n","protected":false},"author":1,"featured_media":3648,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3653"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3653"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3653\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3648"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3653"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}