{"id":3657,"date":"2024-08-31T22:33:42","date_gmt":"2024-08-31T14:33:42","guid":{"rendered":"http:\/\/oncolab.cn\/index.php\/2024\/08\/31\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac38%e7%ab%a0-%e8%a1%80%e6%b6%b2%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%82%bf%e7%98%a4%e5%ad%a6%e7%a0%94%e7%a9%b6%e7%8e%b0%e7%8a%b6%ef%bc%88\/"},"modified":"2024-08-31T22:33:42","modified_gmt":"2024-08-31T14:33:42","slug":"%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac38%e7%ab%a0-%e8%a1%80%e6%b6%b2%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%82%bf%e7%98%a4%e5%ad%a6%e7%a0%94%e7%a9%b6%e7%8e%b0%e7%8a%b6%ef%bc%88","status":"publish","type":"post","link":"http:\/\/oncolab.cn\/index.php\/2024\/08\/31\/%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e5%ad%a6-%e7%ac%ac38%e7%ab%a0-%e8%a1%80%e6%b6%b2%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e8%82%bf%e7%98%a4%e5%ad%a6%e7%a0%94%e7%a9%b6%e7%8e%b0%e7%8a%b6%ef%bc%88\/","title":{"rendered":"\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c38\u7ae0 \u8840\u6db2\u80bf\u7624\u514d\u75ab\u80bf\u7624\u5b66\u7814\u7a76\u73b0\u72b6\uff08\u4e0a\uff09"},"content":{"rendered":"
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\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c37\u7ae0 \u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u6311\u6218\u4e0e\u5e94\u5bf9\u7b56\u7565\u2014\u2014\u4ece\u75ab\u82d7\u7814\u53d1\u5230\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\uff08\u4e0b\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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38.1 \u5f15\u8a00<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5229\u7528\u514d\u75ab\u7cfb\u7edf\u6765\u6d88\u706d\u6076\u6027\u7ec6\u80de\u4e00\u76f4\u662f\u8840\u6db2\u5b66\u5bb6\u548c\u80bf\u7624\u5b66\u5bb6\u7684\u957f\u671f\u8ffd\u6c42\u3002\u5f02\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\uff08HSCT\uff09\u4e3a\u8fd9\u4e00\u68a6\u60f3\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u8fd9\u662f\u9996\u6b21\u5728\u4e34\u5e8a\u4e0a\u6210\u529f\u9a8c\u8bc1\u514d\u75ab\u6cbb\u7597\u5728\u764c\u75c7\u4e2d\u7684\u6f5c\u529b\uff0c\u5c24\u5176\u662f\u5728\u79fb\u690d\u7269\u5bf9\u6297\u767d\u8840\u75c5\u7684\u6548\u679c\u5f97\u5230\u660e\u786e\u8bc1\u660e\u4e4b\u540e\u3002\u5c3d\u7ba1\u540c\u79cd\u5f02\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u5df2\u6210\u4e3a\u5e38\u89c4\u6cbb\u7597\u624b\u6bb5\uff0c\u4f46\u5176\u4e3b\u8981\u5c40\u9650\u6027\u4ecd\u5305\u62ec\u77ed\u671f\u548c\u957f\u671f\u7684\u6bd2\u6027\u3001\u526f\u4f5c\u7528\uff0c\u4ee5\u53ca\u9002\u5408\u8fd9\u79cd\u7597\u6cd5\u7684\u8840\u6db2\u6076\u6027\u80bf\u7624\u79cd\u7c7b\u6709\u9650\u3002\u6b64\u5916\uff0c\u83b7\u53d6\u5e72\u7ec6\u80de\u4f9b\u4f53\u4e5f\u5b58\u5728\u4e00\u5b9a\u56f0\u96be\u3002<\/p>\n

\u7ecf\u8fc7\u6570\u5341\u5e74\u7684\u6df1\u5165\u7814\u7a76\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u5e76\u9a8c\u8bc1\u4e86\u591a\u79cd\u65b0\u7684\u7b56\u7565\uff0c\u4ee5\u6269\u5c55\u514d\u75ab\u6cbb\u7597\u7684\u5e94\u7528\u8303\u56f4\u3002\u9776\u5411\u6076\u6027\u7ec6\u80de\u8868\u9762\u6297\u539f\u662f\u5176\u4e2d\u7684\u5173\u952e\u4e00\u6b65\uff0c\u6297CD20\u5355\u514b\u9686\u6297\u4f53\u5229\u59a5\u6614\u5355\u6297\u5c31\u662f\u8fd9\u4e00\u7b56\u7565\u7684\u5178\u578b\u4ee3\u8868\u3002\u8fd1\u5e74\u6765\uff0c\u9488\u5bf9\u65b0\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\u3001\u65b0\u4e00\u4ee3\u5c06\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u5bfc\u5411\u80bf\u7624\u7ec6\u80de\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08BsAbs\uff09\uff0c\u4ee5\u53ca\u57fa\u56e0\u4fee\u9970\u7684T\u7ec6\u80de\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICB\uff09\u7684\u53d1\u5c55\uff0c\u5728\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u4e86\u6781\u5927\u7684\u6f5c\u529b\uff0c\u6709\u671b\u6210\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u65b0\u524d\u6cbf\u3002\u8fd9\u4e9b\u65b0\u7597\u6cd5\u80fd\u591f\u7a81\u7834\u201c\u764c\u75c7\u514d\u75ab\u8bbe\u5b9a\u70b9\u201d\u7684\u5c4f\u969c\uff0c\u514b\u670d\u764c\u75c7\u8bf1\u5bfc\u7684\u514d\u75ab\u9003\u9038\u673a\u5236\u3002<\/p>\n

\u5728\u672c\u7ae0\u4e2d\uff0c\u6211\u4eec\u5c06\u56de\u987e\u8fd1\u671f\u5173\u4e8e\u514d\u75ab\u80bf\u7624\u5b66\u5728\u8840\u6db2\u5b66\u9886\u57df\u5e94\u7528\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6210\u679c\uff0c\u671f\u671b\u8fd9\u4e9b\u7814\u7a76\u80fd\u591f\u6fc0\u53d1\u8be5\u9886\u57df\u7684\u8fdb\u4e00\u6b65\u63a2\u7d22\uff0c\u4ece\u800c\u663e\u8457\u6539\u5584\u764c\u75c7\u60a3\u8005\u7684\u9884\u540e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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38.2 \u76f4\u63a5\u9776\u5411\u7ec6\u80de\u8868\u9762\u6297\u539f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f53\u6db2\u514d\u75ab\u5728\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e2d\u7684\u6297\u80bf\u7624\u6f5c\u529b\u65e9\u5df2\u88ab\u8bc6\u522b\uff0c\u5e76\u63a8\u52a8\u4e86\u9488\u5bf9\u6076\u6027\u7ec6\u80de\u8868\u9762\u5206\u5b50\u53d1\u5c55\u7684\u5355\u514b\u9686\u6297\u4f53\u6280\u672f\u3002\u5355\u514b\u9686\u6297\u4f53\u7684\u4f5c\u7528\u673a\u5236\u5305\u62ec\u76f4\u63a5\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u3001\u901a\u8fc7Fc\u53d7\u4f53\u4ecb\u5bfc\u7684\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\uff08ADCC\uff09\/\u541e\u566c\uff08ADCP\uff09\u4ee5\u53ca\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\u3002\u901a\u8fc7\u5c06\u6297\u4f53\u4e0e\u7ec6\u80de\u6bd2\u7d20\u7ed3\u5408\u6216\u4fc3\u4f7f\u7ec6\u80de\u5185\u5316\u540e\u7684\u7ec6\u80de\u6bd2\u6027\u6765\u589e\u5f3a\u6740\u4f24\u6548\u679c\uff0c\u4e5f\u662f\u5e38\u89c1\u7b56\u7565\u4e4b\u4e00\u3002<\/p>\n

\u5229\u59a5\u6614\u5355\u6297\uff08rituximab\uff09\u662f\u9996\u4e2a\u6210\u529f\u5f00\u53d1\u5e76\u5e94\u7528\u4e8e\u4e34\u5e8a\u7684\u6297CD20\u5355\u514b\u9686\u6297\u4f53\uff0c\u5728\u8840\u6db2\u5b66\u9886\u57df\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\u3002\u7136\u800c\uff0c\u5728\u63a5\u4e0b\u6765\u7684\u5341\u591a\u5e74\u91cc\uff0c\u5927\u591a\u6570\u9776\u5411\u5176\u4ed6\u7ec6\u80de\u6297\u539f\u7684\u5355\u514b\u9686\u6297\u4f53\u5e76\u672a\u80fd\u5c55\u793a\u51fa\u8db3\u591f\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u968f\u7740\u5bf9\u514d\u75ab\u7f16\u8f91\u548c\u5355\u514b\u9686\u6297\u4f53\u5de5\u7a0b\u6280\u672f\u7684\u6df1\u5165\u7406\u89e3\uff0c\u8fd1\u5e74\u6765\u8fd9\u79cd\u60c5\u51b5\u5f00\u59cb\u597d\u8f6c\uff0c\u4e00\u4e9b\u65b0\u7684\u5355\u514b\u9686\u6297\u4f53\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u6d3b\u6027(Fig 38.1<\/span>)\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig 38.1<\/span>\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u514d\u75ab\u80bf\u7624\u836f\u7269\u53d1\u73b0\u4e0e\u5f00\u53d1\u7684\u5173\u952e\u65f6\u95f4\u70b9<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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38.2.1 CD20\u7684\u6210\u529f\u6545\u4e8b<\/p>\n<\/section>\n

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\u901a\u8fc7\u4eba\u6e90\u5316\u5c0f\u9f20\u6297\u4f53\u6210\u529f\u514b\u670d\u4e86\u5f02\u79cd\u514d\u75ab\u539f\u6027\u8fd9\u4e00\u969c\u788d\uff0c\u6700\u7ec8\u4fc3\u6210\u4e86\u5229\u59a5\u6614\u5355\u6297\u7684\u5f00\u53d1\u3002\u8fd9\u662f\u9996\u4e2a\u9488\u5bf9CD20\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u5728\u590d\u53d1\u6027CD20\u9633\u6027\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u4e86\u524d\u6240\u672a\u6709\u7684\u4e34\u5e8a\u6d3b\u6027\u3002\u57282002\u5e74\u53d1\u8868\u7684\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u7684\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6cd5\u56fdGELA\u5c0f\u7ec4\u8bc1\u660e\uff0c\u5728\u6807\u51c6\u7684CHOP\u65b9\u6848\u4e2d\u52a0\u5165\u5229\u59a5\u6614\u5355\u6297\uff0c\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u8001\u5e74\u60a3\u8005\u7684\u7f13\u89e3\u7387\uff0c\u5e76\u5c06\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u548c\u603b\u4f53\u751f\u5b58\u671f\uff08OS\uff09\u5ef6\u957f\u81f310\u5e74\uff08\u5206\u522b\u4e3a44%\u548c28%\uff09\u3002\u81ea\u6b64\u5173\u952e\u8bd5\u9a8c\u4ee5\u6765\uff0c\u5229\u59a5\u6614\u5355\u6297\u5df2\u88ab\u8bc1\u660e\u5bf9\u51e0\u4e4e\u6240\u6709\u7c7b\u578b\u7684CD20\u9633\u6027B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u6709\u6548\uff0c\u73b0\u5df2\u6210\u4e3a\u60f0\u6027\u548c\u4fb5\u88ad\u6027\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NHL\uff09\u4ee5\u53ca\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u7684\u6807\u51c6\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd1\u5e74\u6765\uff0c\u4e24\u9879\u5927\u578b\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u5229\u59a5\u6614\u5355\u6297\u5728\u6cbb\u7597\u4f2f\u57fa\u7279\u6dcb\u5df4\u7624\u548c\u6210\u4ebaB\u7ec6\u80de\u578b\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u4e2d\u7684\u4f18\u52bf\u3002\u7b2c\u4e8c\u4ee3\u9488\u5bf9CD20\u7684\u5355\u514b\u9686\u6297\u4f53obinutuzumab\uff08GA101\uff09\u662f\u4e00\u79cd\u901a\u8fc7\u7cd6\u57fa\u5de5\u7a0b\u6539\u9020\u7684II\u578b\u4eba\u6e90\u5316\u5355\u6297\uff0c\u8bbe\u8ba1\u65f6\u8003\u8651\u4e86\u5176\u5bf9\u514d\u75ab\u7ec6\u80de\u4e0a\u7684Fc\u03b3RIII\u53d7\u4f53\u5177\u6709\u66f4\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\u8868\u73b0\u51fa\u53ef\u80fd\u4f18\u4e8e\u5229\u59a5\u6614\u5355\u6297\u7684\u6548\u679c\u3002\u4e0e\u5229\u59a5\u6614\u5355\u6297\u76f8\u6bd4\uff0cobinutuzumab\u8868\u73b0\u51fa\u66f4\u76f4\u63a5\u7684\u7ec6\u80de\u6b7b\u4ea1\u8bf1\u5bfc\u4f5c\u7528\u548c\u589e\u5f3a\u7684ADCC\/ADCP\u6d3b\u6027\uff0c\u4f46\u5176\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08CDC\uff09\u8f83\u4f4e\u3002\u6b64\u5916\uff0cobinutuzumab\u4e0e\u5355\u4e2aCD20\u56db\u805a\u4f53\u7ed3\u5408\uff0c\u5185\u5316\u7a0b\u5ea6\u4f4e\u4e8e\u5229\u59a5\u6614\u5355\u6297\uff0c\u8fd9\u53ef\u80fd\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86ADCC\/ADCP\u6548\u5e94\u3002\u5728\u4e00\u9879\u5927\u578b\u968f\u673a\u8bd5\u9a8c\u4e2d\uff0cobinutuzumab\u4e0e\u6c2f\u82ef\u8fbe\u83ab\u53f8\u6c40\u8054\u5408\u4f7f\u7528\u76f8\u6bd4\u4e8e\u4e0e\u5229\u59a5\u6614\u5355\u6297\u7684\u7ec4\u5408\uff0c\u5728\u53cd\u5e94\u7387\u548c\u5b8c\u5168\u7f13\u89e3\u7387\u65b9\u9762\u8868\u73b0\u51fa\u4f18\u52bf\uff0c\u968f\u540e\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8001\u5e74\u6216\u4e0d\u9002\u5408\u8fdb\u884c\u5176\u4ed6\u6cbb\u7597\u7684CLL\u60a3\u8005\u3002\u7136\u800c\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cobinutuzumab\u8054\u5408\u6c2f\u82ef\u8fbe\u83ab\u53f8\u6c40\u7684\u6cbb\u7597\u65b9\u6848\u6bd2\u6027\u66f4\u5927\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728CLL\u7684\u6cbb\u7597\u4e2d\uff0cobinutuzumab\u6b63\u5728\u4e0e\u65b0\u578b\u836f\u7269\u5982Bcl-2\u62ee\u6297\u5242Venetoclax\u548cBTK\u6291\u5236\u5242Ibrutinib\u8054\u5408\u4f7f\u7528\uff0c\u521d\u6b65\u7ed3\u679c\u663e\u793a\u51fa\u5f88\u6709\u5e0c\u671b\u7684\u524d\u666f\uff0c\u8868\u660e\u5728\u4e0d\u4e45\u7684\u5c06\u6765\uff0cobinutuzumab\u53ef\u80fd\u4f1a\u5728CLL\u6cbb\u7597\u4e2d\u5e7f\u6cdb\u5e94\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u5728GADOLIN III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cobinutuzumab\u8054\u5408\u82ef\u8fbe\u83ab\u53f8\u6c40\u6cbb\u7597\u590d\u53d1\u6027\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\uff0c\u76f8\u6bd4\u82ef\u8fbe\u83ab\u53f8\u6c40\u5355\u836f\u6cbb\u7597\uff0c\u663e\u8457\u5ef6\u957f\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u540c\u6837\uff0c\u5728GALLIUM\u7814\u7a76\u4e2d\uff0c\u57fa\u4e8eobinutuzumab\u7684\u8bf1\u5bfc\u548c\u7ef4\u6301\u6cbb\u7597\u663e\u8457\u5ef6\u957f\u4e86\u5148\u524d\u672a\u7ecf\u6cbb\u7597\u7684\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u7684PFS\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5728\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u548cCLL\u4e2d\u89c2\u5bdf\u5230\u7684\u6210\u529f\uff0c\u672a\u5fc5\u80fd\u5728\u66f4\u5177\u4fb5\u88ad\u6027\u7684\u6dcb\u5df4\u7624\u4e2d\u5f97\u5230\u91cd\u590d\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728GOYA\u7814\u7a76\u4e2d\uff0c\u8fd9\u9879\u5927\u578b\u968f\u673aIII\u671f\u8bd5\u9a8c\u6bd4\u8f83\u4e86\u5229\u59a5\u6614\u5355\u6297\u6216obinutuzumab\u8054\u5408CHOP\u6cbb\u7597\u7684\u6548\u679c\uff0c\u6d89\u53ca1418\u4f8b\u672a\u7ecf\u6cbb\u7597\u7684\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\uff0c\u7ed3\u679c\u672a\u80fd\u8fbe\u5230\u5176\u4e3b\u8981\u7ec8\u70b9\uff08\u7814\u7a76\u8005\u8bc4\u4f30\u7684PFS\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

38.2.2 \u9776\u5411CD20\u4ee5\u5916\u7684\u5206\u5b50<\/p>\n<\/section>\n

\n

38.2.2.1 \u963f\u4ed1\u5355\u6297<\/p>\n<\/section>\n

\n
\n
\n

\u963f\u4ed1\u5355\u6297\u662f\u4e00\u79cd\u9488\u5bf9CD52\u7684\u5355\u514b\u9686\u6297\u4f53\uff0cCD52\u662f\u4e00\u79cd\u8868\u8fbe\u5728B\u7ec6\u80de\u3001T\u7ec6\u80de\u548c\u5355\u6838\u7ec6\u80de\u8868\u9762\u7684\u6297\u539f\u3002\u6700\u521d\uff0c\u963f\u4ed1\u5355\u6297\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5bf9\u6c1f\u8fbe\u62c9\u6ee8\u8010\u836f\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u548c\u5177\u6709del17p\u7a81\u53d8\u7684CLL\u3002\u867d\u7136\u963f\u4ed1\u5355\u6297\u5bf9\u4e09\u5206\u4e4b\u4e00\u7684\u6c1f\u8fbe\u62c9\u6ee8\u8010\u836f\u60a3\u8005\u6709\u6548\uff0c\u4f46\u5176\u5e7f\u6cdb\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\u4e0e\u4e25\u91cd\u751a\u81f3\u81f4\u547d\u7684\u673a\u4f1a\u6027\u611f\u67d3\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n

\u5728CLL\u548c\u5176\u4ed6\u6dcb\u5df4\u7624\u4e9a\u578b\u7684\u6cbb\u7597\u4e2d\uff0c\u963f\u4ed1\u5355\u6297\u4e0e\u5316\u7597\u8054\u5408\u4f7f\u7528\u7684\u5927\u591a\u6570\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u672a\u80fd\u663e\u793a\u51fa\u76f8\u8f83\u4e8e\u6807\u51c6\u6cbb\u7597\u7684\u660e\u663e\u4f18\u52bf\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u611f\u67d3\u76f8\u5173\u7684\u9ad8\u6b7b\u4ea1\u7387\uff0c\u4e00\u4e9b\u7814\u7a76\u751a\u81f3\u4e0d\u5f97\u4e0d\u4e2d\u9014\u505c\u6b62\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u540c\u6837\u5730\uff0c\u7531\u4e8e\u5176\u53ef\u80fd\u589e\u52a0\u5371\u53ca\u751f\u547d\u7684\u611f\u67d3\u5e76\u53d1\u75c7\u548c\u8f83\u9ad8\u7684\u75be\u75c5\u590d\u53d1\u7387\uff0c\u963f\u4ed1\u5355\u6297\u5728\u975e\u6e05\u9ad3\u6027\u540c\u79cd\u5f02\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u9884\u5904\u7406\u65b9\u6848\u4e2d\u4f7f\u7528\u4e5f\u53d7\u5230\u9650\u5236\u30022012\u5e74\uff0c\u963f\u4ed1\u5355\u6297\u7528\u4e8e\u8840\u6db2\u6076\u6027\u80bf\u7624\u7684\u5546\u4e1a\u5316\u88ab\u4e2d\u65ad\uff0c\u539f\u56e0\u662f\u5236\u9020\u5546\u8ba1\u5212\u5c06\u5176\u91cd\u65b0\u547d\u540d\u5e76\u7528\u4e8e\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u6cbb\u7597\u3002\u4e0d\u8fc7\uff0c\u5728\u4e00\u4e9b\u56fd\u5bb6\uff0c\u901a\u8fc7\u7279\u5b9a\u5206\u53d1\u7a0b\u5e8f\uff0c\u4ecd\u7136\u53ef\u4ee5\u83b7\u5f97\u963f\u4ed1\u5355\u6297\u7528\u4e8eCLL\u7684\u6cbb\u7597\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

38.2.2.2 \u5409\u59a5\u73e0\u5355\u6297<\/p>\n<\/section>\n

\n
\n
\n

\u5409\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cd\u9488\u5bf9CD33\u8868\u9762\u6297\u539f\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u8026\u8054\u4e86\u5f3a\u6548\u6297\u80bf\u7624\u836f\u7269\u5361\u5229\u51ef\u9709\u7d20\uff08calicheamicin\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u84bd\u73af\u7c7b\u6297\u751f\u7d20\u3002\u5728\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u4e2d\uff0cCD33\u662f\u4e00\u4e2a\u7279\u522b\u6709\u5438\u5f15\u529b\u7684\u9776\u70b9\uff0c\u56e0\u4e3a\u5b83\u5728\u5927\u591a\u6570AML\u7ec6\u80de\u4e2d\u5747\u6709\u8868\u8fbe\u3002\u5409\u59a5\u73e0\u5355\u6297\u5728\u6cbb\u7597\u590d\u53d1\u6027AML\u7684\u8001\u5e74\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684II\u671f\u4e34\u5e8a\u6570\u636e\u540e\u83b7\u5f97FDA\u6279\u51c6\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5728\u4e00\u9879\u5927\u578b\u968f\u673a\u8bd5\u9a8c\u4e2d\u7684\u8d1f\u9762\u7ed3\u679c\uff08\u89c1Rowe\u548cLowenberg\u7684\u6700\u65b0\u7efc\u8ff0\uff09\uff0c\u5409\u59a5\u73e0\u5355\u6297\u7684\u4f7f\u7528\u5f15\u53d1\u4e86\u5e7f\u6cdb\u4e89\u8bae\uff0c\u6700\u7ec8\u88ab\u64a4\u56de\u3002<\/p>\n

\u5c3d\u7ba1\u5982\u6b64\uff0c\u6765\u81ea\u56db\u9879\u968f\u673a\u8bd5\u9a8c\u7684\u6c47\u603b\u6570\u636e\u91cd\u65b0\u6fc0\u53d1\u4e86\u5bf9\u5728\u65b0\u8bca\u65adAML\u4e2d\u4f7f\u7528\u5409\u59a5\u73e0\u5355\u6297\u7684\u5174\u8da3\uff0c\u7279\u522b\u662f\u5728\u7ec6\u80de\u9057\u4f20\u5b66\u8868\u73b0\u66f4\u6709\u5229\u7684\u60a3\u8005\u4e2d\u3002\u6b64\u5916\uff0c\u5409\u59a5\u73e0\u5355\u6297\u5728\u65b0\u8bca\u65ad\u548c\u590d\u53d1\u7684\u6025\u6027\u65e9\u5e7c\u7c92\u7ec6\u80de\u767d\u8840\u75c5\uff08APL\uff09\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u7279\u522b\u9ad8\u7684\u6d3b\u6027\uff0c\u8fd9\u4e9b\u60a3\u8005\u901a\u5e38\u8868\u8fbe\u9ad8\u6c34\u5e73\u7684CD33b\u3002\u9274\u4e8e\u8fc7\u53bb\u4e09\u5341\u5e74\u4e2d\u7f3a\u4e4f\u65b0\u7684AML\u6709\u6548\u836f\u7269\uff0c\u5409\u59a5\u73e0\u5355\u6297\u7684\u4e34\u5e8a\u5e94\u7528\u53ef\u80fd\u5e94\u6839\u636e\u8fd9\u4e9b\u65b0\u7684\u7814\u7a76\u7ed3\u679c\u91cd\u65b0\u8bc4\u4f30\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

38.2.3 \u65b0\u7684\u7814\u7a76\u70ed\u70b9<\/p>\n<\/section>\n

\n

38.2.3.1 \u672c\u59a5\u6614\u5355\u6297<\/p>\n<\/section>\n

\n
\n
\n

\u672c\u59a5\u6614\u5355\u6297\u662f\u4e00\u79cd\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\uff0c\u7531\u9776\u5411CD30\u7684\u5355\u514b\u9686\u6297\u4f53\u4e0e\u5fae\u7ba1\u7834\u574f\u5242MMAE\u901a\u8fc7\u53ef\u88ab\u86cb\u767d\u9176\u5207\u5272\u7684\u8fde\u63a5\u7269\u8026\u8054\u800c\u6210\u3002CD30\u662f\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\u53d7\u4f53\u8d85\u5bb6\u65cf\u7684\u4e00\u4e2a\u6210\u5458\uff0c\u4e3b\u8981\u5728B\u7ec6\u80de\u548cT\u7ec6\u80de\u6d3b\u5316\u540e\u8868\u8fbe\u3002CD30\u7684\u8868\u8fbe\u5df2\u5728\u591a\u79cd\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u80bf\u7624\u4e2d\u88ab\u62a5\u9053\u3002\u5728\u8840\u6db2\u5b66\u4e2d\uff0c\u8868\u8fbeCD30\u7684\u4e3b\u8981\u6076\u6027\u80bf\u7624\u5305\u62ec\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u3001\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff08ALCL\uff09\u3001\u539f\u53d1\u6027\u7eb5\u9694B\u7ec6\u80de\u6dcb\u5df4\u7624\u3001T\u7ec6\u80de\u6dcb\u5df4\u7624\u4ee5\u53caEBV\u8bf1\u5bfc\u7684\u79fb\u690d\u540e\u6dcb\u5df4\u7ec6\u80de\u589e\u751f\u6027\u75be\u75c5\u3002<\/p>\n

\u672c\u59a5\u6614\u5355\u6297\uff08BV\uff09\u5728\u590d\u53d1\/\u96be\u6cbb\u6027CD30\u9633\u6027\u6dcb\u5df4\u7624\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7684\u4e34\u5e8a\u6d3b\u6027\uff0c\u5df2\u88ab\u6279\u51c6\u4f5c\u4e3a\u8be5\u75c5\u75c7\u53caALCL\u7684\u5355\u836f\u6cbb\u7597\u3002\u5728\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u5355\u836f\u6cbb\u7597\u4e2d\uff0cBV\u7684\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a75%\uff0c\u5176\u4e2d\u8fd1\u4e00\u534a\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u590d\u53d1\u7684\u60a3\u8005\u83b7\u5f97\u4e86\u6301\u4e45\u7f13\u89e3\u3002\u4e00\u9879\u8bc4\u4f30BV\u4f5c\u4e3a\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9488\u5bf9\u4e0d\u9002\u5408\u5e38\u89c4\u5316\u7597\u7684\u8001\u5e74\u60a3\u8005\uff0c\u663e\u793a\u51fa\u603b\u7f13\u89e3\u7387\u8fbe92%\uff0c\u5176\u4e2d\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a73%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u591a\u9879I\u671f\u548cII\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cBV\u8054\u5408\u5316\u7597\u548c\u653e\u7597\u8868\u73b0\u51fa\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u53ef\u884c\u6027\u3002\u7136\u800c\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0cBV\u4e0d\u5e94\u4e0e\u542b\u6709\u535a\u83b1\u9709\u7d20\u7684\u65b9\u6848\u8054\u5408\u4f7f\u7528\uff0c\u56e0\u4e3a\u8fd9\u4f1a\u663e\u8457\u589e\u52a0\u80ba\u90e8\u5e76\u53d1\u75c7\u7684\u98ce\u9669\u3002\u5728\u4e00\u9879II\u671f\u8bd5\u70b9\u7814\u7a76\u4e2d\uff0cBV\u4e0ea\u578bVD\u8054\u5408\u4f7f\u7528\u7528\u4e8e\u65e9\u671f\u9ad8\u5371\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5728\u7ecf\u8fc72\u4e2a\u548c4\u4e2a\u5468\u671f\u7684\u6cbb\u7597\u540e\uff0c\u5206\u522b\u670990%\uff0826\/29\uff09\u548c93%\uff0827\/29\uff09\u7684\u60a3\u8005PET\u626b\u63cf\u7ed3\u679c\u4e3a\u9634\u6027\u3002\u76ee\u524d\uff0c\u4e00\u9879\u5927\u578bIII\u671f\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30BV + AVD\u65b9\u6848\u4e0eABVD\u65b9\u6848\u5728\u665a\u671f\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08NCT01712490\uff09\u4e2d\u7684\u7597\u6548\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

AETHERA\u7814\u7a76\u63a2\u7d22\u4e86BV\u5728\u590d\u53d1\u6027\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u4f5c\u4e3a\u5de9\u56fa\u6cbb\u7597\u7684\u6f5c\u529b\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cBV\u7ec4\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a42.9\u4e2a\u6708\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4ec5\u4e3a24.1\u4e2a\u6708\uff0c\u652f\u6301\u4e86BV\u5728\u79fb\u690d\u540e\u73af\u5883\u4e2d\u7684\u6709\u6548\u6027\u3002\u6700\u65b0\u7684\u6570\u636e\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86BV\u5728AETHERA\u7814\u7a76\u4e2d\u7684\u4f18\u8d8a\u6027\u3002\u4e00\u4e9b\u7814\u7a76\u8fd8\u8868\u660e\uff0cBV\u53ef\u4ee5\u5728\u81ea\u4f53\u6216\u540c\u79cd\u5f02\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u590d\u53d1\u7684\u60a3\u8005\u4e2d\u6709\u6548\u63a7\u5236\u75be\u75c5\u3002\u603b\u4f53\u800c\u8a00\uff0cBV\u5728\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\u5c55\u73b0\u51fa\u975e\u5e38\u6709\u524d\u666f\u7684\u6cbb\u7597\u6548\u679c\u3002\u591a\u4e2a\u6b63\u5728\u8fdb\u884c\u7684III\u671f\u968f\u673a\u8bd5\u9a8c\u53ef\u80fd\u4f1a\u5c06BV\u7eb3\u5165\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30BV\u4e0e\u5316\u7597\u8054\u5408\u7528\u4e8e\u672a\u7ecf\u6cbb\u7597\u6216\u590d\u53d1\u7684\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u5728\u5c0f\u89c4\u6a21\u8bd5\u9a8c\u6216\u75c5\u4f8b\u62a5\u544a\u4e2d\uff0cBV\u4e5f\u88ab\u7528\u4e8e\u6cbb\u7597\u5176\u4ed6CD30\u9633\u6027\u7684\u6dcb\u5df4\u7ec6\u80de\u6076\u6027\u80bf\u7624\uff1b\u7136\u800c\uff0c\u4e0e\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u6570\u636e\u7684\u7a33\u5b9a\u6027\u8f83\u5dee\u3002\u572858\u4f8b\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\uff0cBV\u7684\u603b\u7f13\u89e3\u7387\u4e3a85%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u4e3a12.6\u4e2a\u6708\u3002\u76ee\u524d\uff0cI\/II\u671f\u7814\u7a76\u6b63\u5728\u62db\u52df\u60a3\u8005\uff0c\u4ee5\u8bc4\u4f30BV\u8054\u5408\u5316\u7597\u6cbb\u7597CD30\u9633\u6027\u539f\u53d1\u6027\u7eb5\u9694B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08PMBCL\uff09\u3001\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u548c\u7070\u8272\u5730\u5e26\u6dcb\u5df4\u7624\uff08NCT01994850\uff09\u7684\u6548\u679c\u3002\u7279\u522b\u662f\u5728T\u7ec6\u80de\u6dcb\u5df4\u7624\u4e2d\uff0c\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3aT\u7ec6\u80de\u6dcb\u5df4\u7624\u901a\u5e38\u5bf9\u6807\u51c6\u5316\u7597\u8010\u836f\uff0c\u8feb\u5207\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u6765\u6539\u5584\u5176\u9884\u540e\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

38.2.3.2 \u8fbe\u96f7\u6728\u5355\u6297<\/p>\n<\/section>\n

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\n

\u8fbe\u96f7\u6728\u5355\u6297\u662f\u4e00\u79cd\u9776\u5411CD38\u7684IgG1\u5355\u514b\u9686\u6297\u4f53\u3002CD38\u662f\u4e00\u79cd\u8de8\u819c\u7cd6\u86cb\u767d\uff0c\u7531\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u8868\u8fbe\uff0c\u5305\u62ecT\u7ec6\u80de\u3001B\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u3001NK\u7ec6\u80de\u548cNK\/T\u7ec6\u80de\u3002\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u7ec6\u80de\u4e2d\uff0cCD38\u7684\u5e7f\u6cdb\u8868\u8fbe\u4f7f\u5176\u6210\u4e3a\u4e00\u4e2a\u91cd\u8981\u7684\u6cbb\u7597\u9776\u70b9\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u7684\u751f\u7269\u5b66\u6548\u5e94\u4e0d\u4ec5\u9650\u4e8e\u4f20\u7edf\u6cbb\u7597\u6027\u5355\u514b\u9686\u6297\u4f53\u7684\u529f\u80fd\uff0c\u8fd8\u53ef\u80fd\u6d89\u53ca\u514d\u75ab\u8c03\u8282\u3002\u8fbe\u96f7\u6728\u5355\u6297\u53ef\u4ee5\u51cf\u5c11\u8c03\u8282\u6027\u514d\u75ab\u7ec6\u80de\u7684\u6570\u91cf\uff0c\u4f8b\u5982\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff08MDSC\uff09\u3001\u8c03\u8282\u6027B\u7ec6\u80de\u548c\u65b0\u53d1\u73b0\u7684CD38\u9ad8\u8868\u8fbe\u7684\u8c03\u8282\u6027T\u7ec6\u80de\u4e9a\u7fa4\uff0c\u8fd9\u4e00\u4f5c\u7528\u5141\u8bb8CD4+<\/sup>\u8f85\u52a9\u6027T\u7ec6\u80de\u548cCD8+<\/sup>\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u7684\u6269\u589e\uff0c\u5e76\u589e\u52a0IFN-\u03b3\u7684\u4ea7\u751f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5728\u4e24\u9879\u9488\u5bf9\u91cd\u5ea6\u9884\u5904\u7406\u7684\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u4f5c\u4e3a\u5355\u836f\u663e\u793a\u51fa\u663e\u8457\u7684\u7597\u6548\uff0c\u8bf1\u5bfc\u4e86\u9ad8\u6bd4\u4f8b\u7684\u7f13\u89e3\uff0c\u5305\u62ec\u4e25\u683c\u7684\u5b8c\u5168\u7f13\u89e3\u548c\u5ef6\u957f\u7684\u4e34\u5e8a\u7f13\u89e3\u3002\u8fd9\u4e9b\u7ed3\u679c\u4f7f\u5176\u83b7\u5f97\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u5df2\u63a5\u53d7\u81f3\u5c11\u4e09\u79cd\u6cbb\u7597\u65b9\u6848\uff08\u5305\u62ec\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\u548cIMID\u6216\u4e24\u8005\uff09\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u65e9\u671f\u53d1\u8868\u7684CASTOR\u548cPOLLUX\u8bd5\u9a8c\u6570\u636e\u5206\u522b\u8bc4\u4f30\u4e86\u8fbe\u96f7\u6728\u5355\u6297\u4e0e\u787c\u66ff\u4f50\u7c73\u548c\u5730\u585e\u7c73\u677e\u6216\u6765\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u8054\u5408\u4f7f\u7528\u5728\u65e2\u5f80\u6cbb\u7597\u8fc7\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u7814\u7a76\u7684\u968f\u8bbf\u65f6\u95f4\u76f8\u5bf9\u8f83\u77ed\uff08\u5206\u522b\u4e3a7.5\u4e2a\u6708\u548c13.5\u4e2a\u6708\uff09\uff0c\u4f46\u5728\u7f13\u89e3\u7387\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u65b9\u9762\u5747\u663e\u793a\u51fa\u663e\u8457\u6539\u5584\u3002\u5728CASTOR\u8bd5\u9a8c\u4e2d\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u7ec4\u768412\u4e2a\u6708PFS\u4e3a60.7%\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a26.9%\uff1b\u5728POLLUX\u8bd5\u9a8c\u4e2d\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u7ec4\u7684PFS\u4e3a83.2%\uff0c\u5bf9\u7167\u7ec4\u4e3a60.1%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8fbe\u96f7\u6728\u5355\u6297\u7684\u5e94\u7528\u8fc5\u901f\u6269\u5c55\u81f3\u4e00\u7ebf\u6cbb\u7597\uff0c\u5e76\u6b63\u5728\u4e0e\u5176\u4ed6\u6297\u9aa8\u9ad3\u7624\u836f\u7269\u8054\u5408\u8fdb\u884c\u8bc4\u4f30\u3002\u5728\u7b26\u5408\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\uff08HSCT\uff09\u6761\u4ef6\u7684\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\uff0cIFM\u7684CASSIOPEA III\u671f\u5927\u578b\u968f\u673a\u8bd5\u9a8c\u6b63\u5728\u6bd4\u8f83\u6807\u51c6\u6cbb\u7597\u65b9\u6848VTD\uff08\u787c\u66ff\u4f50\u7c73\u3001\u6c99\u5229\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\uff09\u4e0e\u8fbe\u96f7\u6728\u5355\u6297+VTD\u7684\u7597\u6548\uff08NCT02252172\uff09\u3002\u5728\u8001\u5e74\u60a3\u8005\u4e2d\uff0cVMP\uff08\u787c\u66ff\u4f50\u7c73\u3001\u7f8e\u6cd5\u5170\u548c\u6cfc\u5c3c\u677e\uff09\u4e5f\u5728\u4e0e\u8fbe\u96f7\u6728\u5355\u6297+VMP\u8fdb\u884c\u6bd4\u8f83\uff08NCT02195479\uff09\u3002\u5982\u679c\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u80fd\u591f\u8bc1\u5b9e\u5176\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e2d\u7684\u7597\u6548\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u53ef\u80fd\u4f1a\u6210\u4e3a\u201c\u9aa8\u9ad3\u7624\u4e2d\u7684\u5229\u59a5\u6614\u5355\u6297\u201d\u3002<\/p>\n

\u9664\u4e86\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u5916\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u5728\u5176\u4ed6\u8868\u8fbeCD38\u7684\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u4e2d\u7684\u5e94\u7528\u4e5f\u503c\u5f97\u63a2\u7d22\u3002\u4e34\u5e8a\u524d\u6570\u636e\u652f\u6301\u8bc4\u4f30\u8fbe\u96f7\u6728\u5355\u6297\u5728\u9ad8\u5371\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09\u4e2d\u7684\u4f5c\u7528\uff0c\u56e0\u5176\u4e2d\u7684\u6076\u6027B\u7ec6\u80de\u7fa4\u4f53\u901a\u5e38\u9ad8\u8868\u8fbeCD38\u3002\u6700\u8fd1\uff0c\u8fbe\u96f7\u6728\u5355\u6297\u5728\u96be\u6cbb\u6027CD38+ NK\/T\u7ec6\u80de\u6dcb\u5df4\u7624\u4e2d\u4e5f\u53d6\u5f97\u4e86\u6210\u529f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

38.2.3.3 \u827e\u6d1b\u73e0\u5355\u6297<\/p>\n<\/section>\n

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\u827e\u6d1b\u73e0\u5355\u6297\u662f\u4e00\u79cd\u9776\u5411CS1\/SLAMF7\u53d7\u4f53\u7684\u5355\u514b\u9686\u6297\u4f53\u3002SLAMF7\u5728\u6b63\u5e38\u548c\u6076\u6027\u6d46\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u4f46\u5728\u9664NK\u7ec6\u80de\u5916\u7684\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u4e2d\u8868\u8fbe\u8f83\u5c11\u3002\u827e\u6d1b\u73e0\u5355\u6297\u7684\u4f5c\u7528\u673a\u5236\u4e0e\u5176\u4ed6\u5355\u514b\u9686\u6297\u4f53\uff08\u5982\u8fbe\u96f7\u6728\u5355\u6297\uff09\u6709\u6240\u4e0d\u540c\u3002<\/p>\n

\u827e\u6d1b\u73e0\u5355\u6297\u901a\u8fc7\u9996\u5148\u4e0eNK\u7ec6\u80de\u8868\u9762\u7684SLAMF7\u53d7\u4f53\u7ed3\u5408\uff0c\u6fc0\u6d3b\u8fd9\u4e9bNK\u7ec6\u80de\u3002\u88ab\u6fc0\u6d3b\u7684NK\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u5e76\u901a\u8fc7\u5176CD16\u53d7\u4f53\u4e0e\u827e\u6d1b\u73e0\u5355\u6297\u7684Fc\u533a\u7ed3\u5408\u3002\u8fd9\u79cd\u7ed3\u5408\u4f7f\u5f97NK\u7ec6\u80de\u80fd\u591f\u9501\u5b9a\u5e76\u6740\u6b7b\u90a3\u4e9b\u88ab\u827e\u6d1b\u73e0\u5355\u6297\u6807\u8bb0\u7684\u6076\u6027\u6d46\u7ec6\u80de\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u5b9a\u5411\u6740\u4f24\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\n

\u827e\u6d1b\u73e0\u5355\u6297\u4f5c\u4e3a\u5355\u836f\u5728\u6cbb\u7597\u590d\u53d1\/\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u65f6\u6548\u679c\u6709\u9650\u3002\u7136\u800c\uff0c\u5728I\u671f\u8bd5\u9a8c\u4e2d\uff0c\u827e\u6d1b\u73e0\u5355\u6297\u4e0e\u5176\u4ed6\u6297\u9aa8\u9ad3\u7624\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\u663e\u793a\u51fa\u663e\u8457\u6d3b\u6027\u3002\u5728\u4e00\u9879\u968f\u673a\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u7814\u7a76\u4e2d\uff0c\u827e\u6d1b\u73e0\u5355\u6297\u4e0e\u787c\u66ff\u4f50\u7c73\u8054\u5408\u6cbb\u7597\u7565\u5fae\u63d0\u9ad8\u4e86150\u4f8b\u5148\u524d\u6cbb\u7597\u8fc7\u7684MM\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u30021\u5e74\u7684PFS\u7387\u4e3a39%\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a33%\uff1b\u5728\u6700\u65b0\u7684\u5206\u6790\u4e2d\uff0c2\u5e74\u7684PFS\u7387\u4e3a18%\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a11%\u3002<\/p>\n

\u5728\u4e00\u9879\u5927\u578b\u968f\u673a\u591a\u4e2d\u5fc3III\u671fELOQUENT-2\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u6bd4\u8f83\u4e86\u6765\u90a3\u5ea6\u80fa\u548c\u5730\u585e\u7c73\u677e\u8054\u5408\u6216\u4e0d\u8054\u5408\u827e\u6d1b\u73e0\u5355\u6297\u5728\u6cbb\u7597646\u4f8b\u590d\u53d1\/\u96be\u6cbb\u6027MM\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u827e\u6d1b\u73e0\u5355\u6297\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a79%\uff0c\u5bf9\u7167\u7ec4\u4e3a66%\uff1b\u4e2d\u4f4dPFS\u5206\u522b\u4e3a19.4\u4e2a\u6708\u548c14.9\u4e2a\u6708\u3002\u8fd9\u4e9b\u7ed3\u679c\u4fc3\u4f7f\u827e\u6d1b\u73e0\u5355\u6297\u57282015\u5e74\u83b7\u5f97FDA\u7684\u6279\u51c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\n

\u603b\u7684\u6765\u8bf4\uff0c\u827e\u6d1b\u73e0\u5355\u6297\u8054\u5408\u6765\u90a3\u5ea6\u80fa\u5728MM\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u4e00\u5b9a\u7684\u4e34\u5e8a\u6d3b\u6027\uff0c\u5c3d\u7ba1\u5176\u7597\u6548\u4f3c\u4e4e\u4e0d\u5982\u8fbe\u96f7\u6728\u5355\u6297\u90a3\u6837\u663e\u8457\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u4ecd\u7136\u9700\u8981\u6765\u660e\u786e\u827e\u6d1b\u73e0\u5355\u6297\u5728MM\u6cbb\u7597\u4e2d\u7684\u786e\u5207\u5730\u4f4d\uff0c\u7279\u522b\u662f\u786e\u5b9a\u5176\u6700\u4f73\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

38.2.3.4 \u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u4f53<\/p>\n<\/section>\n

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\u524d\u9762\u7684\u7ae0\u8282\u4e2d\u63d0\u5230\uff0c\u5355\u514b\u9686\u6297\u4f53\u63d0\u4f9b\u4e86\u4e00\u79cd\u6bd4\u6807\u51c6\u5316\u7597\u66f4\u5177\u9009\u62e9\u6027\u3001\u4e14\u6bd2\u6027\u66f4\u5c0f\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u7136\u800c\uff0c\u5355\u514b\u9686\u6297\u4f53\u7684\u4e00\u4e2a\u4e3b\u8981\u7f3a\u70b9\u662f\uff0c\u5b83\u4eec\u65e0\u6cd5\u6709\u6548\u5730\u5c06\u7ec6\u80de\u6bd2\u6027T\u6dcb\u5df4\u7ec6\u80de\uff08CTL\uff09\u62db\u52df\u5230\u80bf\u7624\u533a\u57df\uff0c\u4e5f\u65e0\u6cd5\u5c06\u975e\u708e\u75c7\u6027\u80bf\u7624\u5fae\u73af\u5883\u8f6c\u53d8\u4e3a\u708e\u75c7\u6027\u73af\u5883\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u6d78\u6da6\u7684T\u7ec6\u80de\u6570\u91cf\u4e0e\u4e0d\u540c\u764c\u75c7\u7684\u4e34\u5e8a\u7ed3\u679c\u76f4\u63a5\u76f8\u5173\u3002\u81ea\u5229\u59a5\u6614\u5355\u6297\u5f00\u53d1\u4ee5\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u82b1\u8d39\u4e86\u5341\u591a\u5e74\u7684\u65f6\u95f4\uff0c\u8bd5\u56fe\u627e\u5230\u80fd\u591f\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u76f4\u63a5\u589e\u52a0\u548c\u6fc0\u6d3b\u7279\u5f02\u6027CTL\u7684\u65b9\u6cd5\u3002\u8fd9\u79cd\u7814\u7a76\u7684\u8303\u5f0f\u8f6c\u53d8\uff0c\u6210\u529f\u50ac\u751f\u4e86\u4e24\u79cd\u4e0d\u540c\u7684\u4e34\u5e8a\u7b56\u7565\uff1a<\/p>\n

1. \u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICBs\uff09\uff1a\u901a\u8fc7\u6291\u5236T\u7ec6\u80de\u8868\u9762\u6291\u5236\u6027\u53d7\u4f53\u548c\u914d\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5982PD-1\u548cCTLA-4\uff0cICBs\u80fd\u591f\u91ca\u653eT\u7ec6\u80de\u4ecb\u5bfc\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u4f7f\u5176\u5728\u542f\u52a8\u671f\u548c\u6548\u5e94\u671f\u66f4\u52a0\u6d3b\u8dc3\u3002<\/p>\n

2. \u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\u7ec6\u80de\uff09\uff1a\u901a\u8fc7\u8f6c\u5bfc\u81ea\u4f53T\u7ec6\u80de\uff0c\u4f7f\u5176\u8868\u8fbe\u7279\u5f02\u6027\u6297\u539f\u7ed3\u5408\u57df\u548c\u7ec6\u80de\u5185\u4fe1\u53f7\u53d7\u4f53\uff0c\u4ece\u800c\u7ed5\u8fc7T\u7ec6\u80de\u8017\u7aed\uff0c\u91cd\u65b0\u5f15\u5bfcCTL\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u6740\u4f24\u764c\u7ec6\u80de\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7136\u800c\uff0c\u7531\u4e8e\u5728\u826f\u597d\u751f\u4ea7\u89c4\u8303\uff08GMP\uff09\u8bbe\u65bd\u4e2d\u4e3a\u6bcf\u4f4d\u60a3\u8005\u5236\u9020\u4e2a\u6027\u5316CAR-T\u7ec6\u80de\u7684\u6210\u672c\u3001\u590d\u6742\u6027\u548c\u65f6\u95f4\u5ef6\u8fdf\uff0c\u79d1\u5b66\u5bb6\u4eec\u63a2\u7d22\u4e86\u53e6\u4e00\u79cd\u91cd\u5b9a\u5411T\u7ec6\u80de\u7684\u7b56\u7565\uff0c\u5373\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08BsAb\uff09\u7684\u53d1\u5c55\u3002\u8fd9\u79cd\u7b56\u7565\u88ab\u8ba4\u4e3a\u662f\u6700\u91cd\u8981\u7684\u521b\u65b0\u4e4b\u4e00\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08BsAb\uff09\u53c8\u79f0\u53cc\u9776\u5411\u6297\u4f53\uff0c\u5177\u6709\u540c\u65f6\u7ed3\u5408\u4e24\u4e2a\u4e0d\u540c\u76ee\u6807\u7684\u80fd\u529b\uff0c\u4f7fT\u7ec6\u80de\u4e0e\u764c\u7ec6\u80de\u63a5\u89e6\u3002\u8fd9\u79cd\u6280\u672f\u80fd\u591f\u8ba9\u60a3\u8005\u4f53\u5185\u7684CTL\u76f4\u63a5\u4e0e\u764c\u7ec6\u80de\u63a5\u89e6\uff0c\u5e76\u4fc3\u4f7f\u80bf\u7624\u7684\u6301\u7eed\u6eb6\u89e3\u3002\u7ee7\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u6cbb\u7597\u4e2d\u7684\u6210\u529f\u4e4b\u540e\uff0cBsAb\u6210\u4e3a\u53d1\u5c55\u6700\u5feb\u7684\u6297\u764c\u7597\u6cd5\u4e4b\u4e00\uff0c\u76ee\u524d\u5df2\u670950\u591a\u79cdBsAb\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f8b\u5982\uff0cBlinatumomab\u662f\u4e00\u79cd\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u4f53\uff08BiTe\uff09\uff0c\u7531\u4e24\u4e2a\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\uff08scFv\uff09\u7ec4\u6210\uff0c\u901a\u8fc7\u4e00\u4e2a\u7075\u6d3b\u7684\u77ed\u8fde\u63a5\u4f53\u8fde\u63a5(Fig 38.2<\/span>)\u3002N\u7aef\u7684scFv\u8bc6\u522b\u80bf\u7624\u76f8\u5173\u6297\u539f\uff08TAA\uff09\uff0cC\u7aef\u7684scFv\u5219\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u7684CD3\u03b5\u3002\u4e24\u4e2a\u81c2\u4e4b\u95f4\u7684\u8fde\u63a5\u4f53\u8d4b\u4e88\u4e86Blinatumomab\u9ad8\u5ea6\u7684\u7075\u6d3b\u6027\uff0c\u8fd9\u79cd\u7ed3\u6784\u65e0\u9700\u4f9d\u8d56T\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u7684\u7279\u5f02\u6027\u548c\u80bd\u6297\u539f\u7684\u5448\u9012\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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Fig <\/span>38.2<\/span> \u5c55\u793a\u4e86Blinatumomab\u7684\u7ed3\u6784\u548c\u4f5c\u7528\u673a\u5236<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u56e0\u6b64\uff0cBlinatumomab\u53ef\u4ee5\u7ed5\u8fc7CTL\u4e0a\u7684MHC I-TCR\u8f74\uff0c\u4f7f\u591a\u514b\u9686T\u7ec6\u80de\u80fd\u591f\u88ab\u62db\u52df\u5230\u80bf\u7624\u5fae\u73af\u5883\u4e2d\uff0c\u4ece\u800c\u514b\u670d\u80bf\u7624\u7ec6\u80de\u4e0a\u5e38\u89c1\u7684MHC\u5206\u5b50\u4e0b\u8c03\u95ee\u9898\u3002\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c\u7c7b\u4f3cBlinatumomab\uff08CD3\/CD19\uff09\u7684BsAb\u53ef\u4ee5\u89e6\u53d1\u6548\u5e94T\u7ec6\u80de\u4e0e\u767d\u8840\u75c5\u7ec6\u80de\u4e4b\u95f4\u7684\u514d\u75ab\u7a81\u89e6\u5f62\u6210\u3002\u8fd9\u4e9b\u7a81\u89e6\u5141\u8bb8T\u7ec6\u80de\u91ca\u653e\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176\uff08\u6210\u5b54\u86cb\u767d\uff09\uff0c\u8fdb\u4e00\u6b65\u5f15\u53d1\u7ec6\u80de\u6838\u7684\u51dd\u96c6\u548c\u819c\u7684\u8d77\u6ce1\u3002\u6b64\u5916\uff0c\u514d\u75ab\u7a81\u89e6\u8fd8\u4f1a\u5bfc\u81f4\u514d\u75ab\u6fc0\u6d3b\u53d7\u4f53\u5982CD25\u548cCD69\u7684\u4e0a\u8c03\uff0c\u5e76\u4fc3\u8fdb\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u5982IL-2\u3001IFN-\u03b3\u548cIL-6\u7684\u4ea7\u751f\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u4f7f\u7528Blinatumomab\u540e\uff0cCD4+<\/sup>\u548cCD8+ <\/sup>T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6fc0\u6d3b\u90fd\u4e0d\u9700\u8981\u989d\u5916\u7684IL-2\u8865\u5145\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u7f57\u8377<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u90ed\u5b50 \u5e94\u6b63<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n


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\u2589  \u5f80\u671f\u63a8\u9001\u5408\u8f91<\/strong><\/strong><\/section>\n
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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

\u795e\u7ecf\u79d1\u5b66\u539f\u7406\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5173\u6ce8\u672c\u53f7~<\/span>
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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

\uff08\u6dfb\u52a0\u8bf7\u5907\u6ce8\u5355\u4f4d\u59d3\u540d\uff09<\/span><\/p>\n


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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u80bf\u7624\u514d\u75ab\u5b66-\u7b2c37\u7ae0 \u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u7597\u6311\u6218\u4e0e\u5e94\u5bf9\u7b56\u7565\u2014\u2014\u4ece\u75ab\u82d7\u7814\u53d1\u5230\u5de8\u566c\u7ec6\u80de\u590d\u6781\u5316\uff08\u4e0b\uff09 38.1 \u5f15…<\/p>\n","protected":false},"author":1,"featured_media":3654,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[65],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3657"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3657"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3657\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3654"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3657"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}