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39.1 \u7b80\u4ecb<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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39.2 \u786e\u5b9a\u5408\u9002\u7684\u6297\u539f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n

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39.3 \u80f6\u8d28\u7624\u4e2d\u7684\u65b0\u8868\u4f4d<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u65e9\u671f\u7814\u7a76\u8fd8\u663e\u793a\uff0c\u5927\u591a\u6570\u590d\u53d1\u60a3\u8005\u4e2dEGFRvIII\u5df2\u4e0d\u518d\u53ef\u68c0\u6d4b\uff0c\u8fd9\u8868\u660eEGFRvIII PepKLH\uff08Rindopepimut\u00ae\uff09\u5728\u65b0\u8bca\u65ad\u7684EGFRvIII\u9633\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u4e2d\uff0c\u4f5c\u4e3a\u8054\u5408\u653e\u5316\u7597\uff08temozolomide\uff09\u7684\u8f85\u52a9\u6cbb\u7597\u63aa\u65bd\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u751f\u7269\u5b66\u7597\u6548\u3002\u7136\u800c\uff0c\u5728\u4e00\u9879\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u6ce8\u518c\u8bd5\u9a8c\uff08ACT-IV\uff0cNCT01480479\uff09\u4e2d\uff0c\u8be5\u75ab\u82d7\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0cRindopepimut\u00ae\u7ec4\u7684\u603b\u751f\u5b58\u671f\u4e3a20.4\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a21.1\u4e2a\u6708\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u5fb7\u56fd\u7684\u516b\u4e2a\u7814\u7a76\u5730\u70b9\uff0c30\u540d\u53ef\u8bc4\u4f30\u7684\u65b0\u8bca\u65ad3\u7ea7\u62164\u7ea7\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u7624\u60a3\u8005\u5df2\u5b8c\u6210\u62db\u52df\uff0c\u8fd9\u9879\u591a\u4e2d\u5fc3I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT02454634\uff09\u65e8\u5728\u8bc4\u4f30\u75ab\u82d7\u7684\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\u3002\u60a3\u8005\u63a5\u53d7\u4e868\u6b2120-mer\u80bd\uff08\u5728Montanide-ISA51\u00ae\u4e73\u5316\u5242\u4e2d\uff09\u63a5\u79cd\uff0c\u8be5\u6cbb\u7597\u88ab\u6574\u5408\u5230\u4e3b\u8981\u6cbb\u7597\u65b9\u6848\u4e2d\u3002\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u548c\u514d\u75ab\u539f\u6027\uff0c\u7279\u522b\u662fT\u7ec6\u80de\u548c\u6297\u4f53\u53cd\u5e94\u7684\u8bc1\u636e\u3002\u76ee\u524d\u4ecd\u9700\u8fdb\u4e00\u6b65\u63a2\u8ba8\u7684\u91cd\u8981\u95ee\u9898\u5305\u62ec\uff1aCD4+ IDH1R132H\u7279\u5f02\u6027T\u7ec6\u80de\u7684\u4f5c\u7528\u673a\u5236\u3001CD8\u8868\u4f4d\u7684\u6297\u539f\u6269\u6563\u7a0b\u5ea6\u4ee5\u53ca\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u4e2d\u80bf\u7624\u5185T\u7ec6\u80de\u7684\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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IDH1R132H\u3001H3.3K27M\u548cEGFRvIII\u662f\u80f6\u8d28\u7624\u4e2d\u5e38\u89c1\u6216\u5171\u4eab\u7684\u65b0\u8868\u4f4d\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u80f6\u8d28\u7624\u4e2d\u7684\u65b0\u8868\u4f4d\u662f\u79c1\u6709\u8868\u4f4d\u3002\u4e3a\u4e86\u9488\u5bf9\u60a3\u8005\u7279\u5f02\u6027\u7684\u65b0\u6297\u539f\uff0c\u5b9e\u65bd\u4e86\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6cd5\u3002\u76ee\u524d\uff0c\u57fa\u4e8eHLA\u7ed3\u5408\u9884\u6d4b\u7684\u7a81\u53d8\u8868\u4f4d\u8ba1\u7b97\u6d41\u7a0b\uff0c\u4e00\u9879I\u671f\u7814\u7a76\u6b63\u5728\u6d4b\u8bd5\u4e2a\u6027\u5316\u80bd\u75ab\u82d7\uff08NeoVax\uff09\u5bf9\u65b0\u8bca\u65ad\u7684MGMT\u672a\u7532\u57fa\u5316\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7684\u7597\u6548\uff08NCT02287428\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u4e8e\u5168\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u548cHLA\u914d\u4f53\u7ec4\u5206\u6790\uff0c\u6b27\u6d32\u80f6\u8d28\u7624\u79ef\u6781\u4e2a\u6027\u5316\u75ab\u82d7\u8054\u76df\uff08GAPVAC\uff09\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u591a\u4e2d\u5fc3\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u6d4b\u8bd5\u9488\u5bf9\u65b0\u8bca\u65ad\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u7684\u4e2a\u4f53\u5316\u65b0\u8868\u4f4d\u75ab\u82d7\uff08GAPVAC-101\uff0cNCT02149225\uff09\u3002\u867d\u7136\u8fd9\u79cd\u4e2a\u6027\u5316\u65b9\u6cd5\u589e\u52a0\u4e86\u8868\u4f4d\u53d1\u73b0\u7684\u590d\u6742\u6027\uff0c\u4f46\u75ab\u82d7\u751f\u4ea7\u7684\u5468\u8f6c\u65f6\u95f4\u4ecd\u8db3\u4ee5\u4e0e\u4e3b\u8981\u6cbb\u7597\u76f8\u6574\u5408\u3002\u7531\u4e8e\u8fd9\u4e9b\u4e2a\u6027\u5316\u6982\u5ff5\u5177\u6709\u76d1\u7ba1\u6311\u6218\uff0c\u5fc5\u987b\u5728\u6267\u884c\u524d\u83b7\u5f97\u57fa\u4e8e\u63d0\u8bae\u5de5\u4f5c\u6d41\u7a0b\u7684\u4e2a\u6027\u5316\u6574\u5408\u5206\u5b50\u75c5\u7406\u5b66\uff08IMP\uff09\u7684\u6279\u51c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7531Oncolab\u5fae\u4fe1\u516c\u4f17\u53f7\u7ffb\u8bd1\u6574\u7406\u81eaOncoimmunology: A Practical Guide for Cancer Immunotherapy\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Oncoimmunology: A Practical Guide <\/span><\/p>\n

for Cancer Immunotherapy<\/span><\/p>\n

\u521d\u7a3f\u7ffb\u8bd1 | \u4efb\u632f\u9633<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u90ed\u9707\u8fdc \u9ea6\u601d\u6dcb<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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