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\u4e0a\u671f\u5185\u5bb9\uff1a\u795e\u7ecf\u79d1\u5b66\u539f\u7406-\u7b2c2\u7ae0 \u57fa\u56e0\u548c\u884c\u4e3a\uff08\u4e0a\uff09<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.6 \u901a\u8fc7\u7814\u7a76\u4eba\u7c7b\u9057\u4f20\u7efc\u5408\u75c7\u521d\u6b65\u63ed\u793a\u793e\u4f1a\u884c\u4e3a\u7684\u57fa\u7840<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.6.1 \u4eba\u7c7b\u8111\u90e8\u75be\u75c5\u662f\u57fa\u56e0\u4e0e\u73af\u5883\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c<\/strong><\/p>\n<\/section>\n

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2.6.2 \u7f55\u89c1\u7684\u795e\u7ecf\u53d1\u80b2\u7efc\u5408\u75c7\u4e3a\u793e\u4f1a\u884c\u4e3a\u3001\u77e5\u89c9\u548c\u8ba4\u77e5\u7684\u751f\u7269\u5b66\u63d0\u4f9b\u4e86\u89c1\u89e3<\/strong><\/p>\n<\/section>\n

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\u5728\u81ea\u95ed\u75c7\u513f\u7ae5\u4e2d\uff0c\u8bed\u8a00\u76f8\u5173\u7684\u5927\u8111\u533a\u57df\u53d7\u635f\uff0c\u800c\u8fd9\u4e9b\u533a\u57df\u5728\u5a01\u5ec9\u65af\u7efc\u5408\u75c7\u60a3\u8005\u4e2d\u5374\u8868\u73b0\u6d3b\u8dc3\u6216\u8fc7\u5ea6\u6d3b\u8dc3\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5a01\u5ec9\u65af\u7efc\u5408\u75c7\u60a3\u8005\u7684\u4e00\u822c\u667a\u529b\u548c\u7a7a\u95f4\u667a\u529b\u53d7\u635f\u7a0b\u5ea6\u8fdc\u9ad8\u4e8e\u5927\u591a\u6570\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u513f\u7ae5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2011\u5e74\uff0c\u4e24\u9879\u5927\u89c4\u6a21\u7814\u7a76\u540c\u65f6\u5bf9\u4e00\u4e2a\u660e\u786e\u5b9a\u4e49\u7684\u961f\u5217\u8fdb\u884c\u4e86\u53bb\u65b0\u62f7\u8d1d\u6570\u53d8\u5f02\u7684\u5206\u6790\uff0c\u53d1\u73b0\u5a01\u5ec9\u7efc\u5408\u75c7\u4e2d\u7f3a\u5931\u7684\u540c\u4e00\u533a\u57df\u5728\u67d0\u4e9b\u4e2a\u4f53\u4e2d\u663e\u8457\u589e\u52a0\u4e86\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u98ce\u9669\u3002\u7136\u800c\uff0c\u5728\u8fd9\u4e9b\u6848\u4f8b\u4e2d\uff0c\u5bfc\u81f4\u98ce\u9669\u589e\u52a0\u7684\u5e76\u975e\u7f3a\u5931\uff0c\u800c\u662f\u8be5\u533a\u57df\u7684\u989d\u5916\u526f\u672c\uff08\u91cd\u590d\uff09\u3002\u8fd9\u4e9b\u53d1\u73b0\u8868\u660e\uff0c\u76f8\u540c\u4e00\u7ec4\u57fa\u56e0\u7684\u4e22\u5931\u548c\u589e\u52a0\u53ef\u80fd\u4f1a\u5bfc\u81f4\u622a\u7136\u4e0d\u540c\u7684\u793e\u4f1a\u884c\u4e3a\u8868\u578b\uff0c\u5c3d\u7ba1\u4e24\u8005\u901a\u5e38\u90fd\u4e0e\u667a\u529b\u969c\u788d\u6709\u5173\u3002\u8fd9\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8ba4\u77e5\u548c\u884c\u4e3a\u529f\u80fd\u9886\u57df\u53ef\u4ee5\u5206\u79bb\uff0c\u4f46\u53ef\u80fd\u5171\u4eab\u91cd\u8981\u7684\u5206\u5b50\u673a\u5236\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8106\u6027X\u7efc\u5408\u75c7\u662f\u53e6\u4e00\u79cd\u63d0\u4f9b\u8ba4\u77e5\u529f\u80fd\u9057\u4f20\u5b66\u6df1\u5165\u89c1\u89e3\u7684\u513f\u7ae5\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u3002\u4e0e\u5a01\u5ec9\u7efc\u5408\u75c7\u4e0d\u540c\uff0c\u8106\u6027X\u7efc\u5408\u75c7\u5df2\u88ab\u5b9a\u4f4d\u5230X\u67d3\u8272\u4f53\u4e0a\u7684\u5355\u4e2a\u57fa\u56e0\u3002\u8106\u6027X\u7efc\u5408\u75c7\u7684\u8868\u73b0\u5404\u4e0d\u76f8\u540c\uff0c\u53d7\u5f71\u54cd\u7684\u513f\u7ae5\u53ef\u80fd\u8868\u73b0\u51fa\u667a\u529b\u969c\u788d\u3001\u793e\u4ea4\u8ba4\u77e5\u56f0\u96be\u3001\u9ad8\u5ea6\u793e\u4ea4\u7126\u8651\u548c\u91cd\u590d\u884c\u4e3a\uff1b\u5927\u7ea630%\u7684\u8106\u6027X\u7efc\u5408\u75c7\u7537\u5b69\u7b26\u5408\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u7684\u8bca\u65ad\u6807\u51c6\u3002\u6b64\u5916\uff0c\u8106\u6027X\u7efc\u5408\u75c7\u8fd8\u4e0e\u4e00\u4e9b\u8eab\u4f53\u7279\u5f81\u6709\u5173\uff0c\u4f8b\u5982\u957f\u8138\u548c\u7a81\u51fa\u7684\u8033\u6735\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u53e6\u4e00\u79cd\u5e7f\u4e3a\u4eba\u77e5\u7684\u5b5f\u5fb7\u5c14\u9057\u4f20\u75be\u75c5\u662f\u96f7\u7279\u7efc\u5408\u75c7\uff08\u5728\u7b2c62\u7ae0<\/span>\u4e2d\u8be6\u7ec6\u8ba8\u8bba\uff09\u3002\u96f7\u7279\u7efc\u5408\u75c7\u662f\u4e00\u79cdX\u8fde\u9501\u7684\u8fdb\u884c\u6027\u795e\u7ecf\u53d1\u80b2\u969c\u788d\uff0c\u662f\u5973\u6027\u667a\u529b\u969c\u788d\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u8fd9\u79cd\u75be\u75c5\u51e0\u4e4e\u53ea\u5f71\u54cd\u5973\u6027\uff0c\u56e0\u4e3a\u5178\u578b\u7684\u96f7\u7279\u7efc\u5408\u75c7\u7a81\u53d8\u5728\u53d1\u80b2\u4e2d\u7684\u7537\u6027\u80da\u80ce\u4e2d\u901a\u5e38\u662f\u81f4\u547d\u7684\uff0c\u7537\u6027\u53ea\u6709\u4e00\u6761X\u67d3\u8272\u4f53\u3002\u53d7\u5f71\u54cd\u7684\u5973\u5b69\u901a\u5e38\u57286\u81f318\u4e2a\u6708\u5927\u65f6\uff0c\u53d1\u80b2\u51fa\u73b0\u505c\u6ede\uff0c\u8bed\u8a00\u80fd\u529b\u672a\u80fd\u6b63\u5e38\u83b7\u5f97\uff0c\u667a\u529b\u529f\u80fd\u5f00\u59cb\u9000\u5316\uff0c\u5e76\u4e14\u8868\u73b0\u51fa\u5f3a\u8feb\u6027\u3001\u4e0d\u53d7\u63a7\u5236\u7684\u624b\u90e8\u626d\u52a8\uff0c\u800c\u975e\u6709\u76ee\u7684\u7684\u624b\u90e8\u52a8\u4f5c\u3002\u6b64\u5916\uff0c\u60a3\u6709\u96f7\u7279\u7efc\u5408\u75c7\u7684\u5973\u5b69\u901a\u5e38\u4f1a\u7ecf\u5386\u4e00\u6bb5\u65f6\u95f4\u7684\u793e\u4ea4\u4e92\u52a8\u660e\u663e\u53d7\u635f\uff0c\u8fd9\u53ef\u80fd\u4e0e\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u96be\u4ee5\u533a\u5206\uff0c\u5c3d\u7ba1\u793e\u4ea4\u529f\u80fd\u5728\u540e\u671f\u751f\u6d3b\u4e2d\u901a\u5e38\u4f1a\u6709\u6240\u6539\u5584\u3002\u80e1\u8fbe\u00b7\u4f50\u683c\u6bd4\u548c\u5979\u7684\u56e2\u961f\u53d1\u73b0\uff0c\u8fd9\u79cd\u7efc\u5408\u75c7\u7684\u4e3b\u8981\u539f\u56e0\u662f\u7532\u57faCpG\u7ed3\u5408\u86cb\u767d2\uff08MeCP2\uff09\u57fa\u56e0\u7684\u7a81\u53d8\u3002\u7279\u5b9aCpG\u5e8f\u5217\u7684DNA\u7532\u57fa\u5316\u4f1a\u6539\u53d8\u90bb\u8fd1\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u800cMeCP2\u7684\u4f5c\u7528\u4e4b\u4e00\u662f\u7ed3\u5408\u7532\u57fa\u5316DNA\uff0c\u8c03\u63a7\u4fe1\u4f7fRNA\u7684\u8f6c\u5f55\u8fc7\u7a0b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7f55\u89c1\u7efc\u5408\u75c7\u8fd8\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e9b\u5173\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u9057\u4f20\u57fa\u7840\u7684\u521d\u6b65\u89c1\u89e3\uff08\u89c1\u7b2c60\u7ae0<\/span>\uff09\u3002\u4f8b\u5982\uff0c1978\u5e74\uff0c\u7f57\u4f2f\u6258\u00b7\u4ec0\u666e\u6797\u8328\u6069\u53ca\u5176\u540c\u4e8b\u9996\u6b21\u63cf\u8ff0\u4e8622q11\u67d3\u8272\u4f53\u7f3a\u5931\uff0c\u53d1\u73b0\u8fd9\u79cd\u7f3a\u5931\u4f1a\u5bfc\u81f4\u5e7f\u6cdb\u7684\u8eab\u4f53\u548c\u884c\u4e3a\u75c7\u72b6\uff0c\u5305\u62ec\u7cbe\u795e\u75c5\u3002\u73b0\u5728\uff0c\u8fd9\u79cd\u60c5\u51b5\u901a\u5e38\u88ab\u79f0\u4e3a\u816d\u5fc3\u9762\u7efc\u5408\u75c7\u3001\u8fea\u683c\u5965\u5c14\u683c\u7efc\u5408\u75c7\u621622q11\u7f3a\u5931\u7efc\u5408\u75c7\u3002\u7531\u4e8e\u4e0e\u76f8\u540c\u7f3a\u5931\u76f8\u5173\u7684\u8868\u578b\u5dee\u5f02\u975e\u5e38\u5927\uff0c\u6700\u521d\u8fd9\u79cd\u63cf\u8ff0\u53d7\u5230\u4e86\u8d28\u7591\u3002\u7136\u800c\uff0c\u73b0\u5728\u5df2\u666e\u904d\u63a5\u53d7\uff0c22q11\u7f3a\u5931\u662f\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u513f\u7ae5\u671f\u53d1\u75c5\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u6700\u5e38\u89c1\u67d3\u8272\u4f53\u5f02\u5e38\u4e4b\u4e00\u3002\u6b64\u5916\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u540c\u4e00\u533a\u57df\u7684\u67d3\u8272\u4f53\u7f3a\u5931\u4e5f\u4e0e\u81ea\u95ed\u75c7\u98ce\u9669\u589e\u52a0\u6709\u5173\u3002\u867d\u7136\u76ee\u524d\u5c1a\u672a\u786e\u5b9a\u8be5\u533a\u57df\u5185\u5177\u4f53\u5bfc\u81f4\u7cbe\u795e\u75c5\u8868\u578b\u7684\u57fa\u56e0\uff0c\u4f46\u6765\u81ea\u81ea\u95ed\u75c7\u7814\u7a76\u7684\u6700\u65b0\u8bc1\u636e\u8868\u660e\uff0c\u8fd9\u4e00\u533a\u57df\u5185\u591a\u4e2a\u57fa\u56e0\u7684\u7ec4\u5408\u2014\u2014\u6bcf\u4e2a\u57fa\u56e0\u90fd\u5177\u6709\u76f8\u5bf9\u8f83\u5c0f\u7684\u6548\u5e94\u2014\u2014\u53ef\u80fd\u5171\u540c\u5bfc\u81f4\u4e86\u793e\u4f1a\u969c\u788d\u7684\u8868\u578b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.7 \u7cbe\u795e\u75be\u75c5\u6d89\u53ca\u591a\u57fa\u56e0\u7279\u5f81<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u672c\u7ae0\u7684\u4f59\u4e0b\u90e8\u5206\uff0c\u6211\u4eec\u5c06\u6df1\u5165\u63a2\u8ba8\u4e24\u79cd\u590d\u6742\u795e\u7ecf\u53d1\u80b2\u548c\u7cbe\u795e\u75be\u75c5\u7684\u9057\u4f20\u5b66\uff1a\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u3002\u4e0e\u524d\u9762\u8ba8\u8bba\u7684\u7f55\u89c1\u5b5f\u5fb7\u5c14\u9057\u4f20\u75c5\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u5e38\u89c1\u75be\u75c5\u7684\u9057\u4f20\u5b66\u66f4\u52a0\u590d\u6742\u3001\u591a\u6837\u4e14\u5f02\u8d28\uff0c\u6d89\u53ca\u8bb8\u591a\u4e0d\u540c\u4e2a\u4f53\u4e2d\u7684\u4f17\u591a\u57fa\u56e0\uff0c\u4ee5\u53ca\u591a\u4e2a\u5171\u540c\u4f5c\u7528\u63d0\u4f9b\u6613\u611f\u6027\u7684\u98ce\u9669\u57fa\u56e0\u3002\u6b64\u5916\uff0c\u5c3d\u7ba1\u6709\u5927\u91cf\u8bc1\u636e\u8868\u660e\u8fd9\u4e9b\u75be\u75c5\u6709\u663e\u8457\u7684\u9057\u4f20\u6210\u5206\uff0c\u4f46\u73af\u5883\u56e0\u7d20\u7684\u5f71\u54cd\u540c\u6837\u4e0d\u53ef\u5ffd\u89c6\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5bf9\u8fd9\u4e9b\u75be\u75c5\u7684\u7406\u89e3\u5f97\u76ca\u4e8e\u57fa\u56e0\u7ec4\u6280\u672f\u548c\u7edf\u8ba1\u65b9\u6cd5\u7684\u5feb\u901f\u53d1\u5c55\u3001\u5f00\u653e\u6570\u636e\u5171\u4eab\u7684\u6587\u5316\uff0c\u4ee5\u53ca\u5927\u89c4\u6a21\u60a3\u8005\u961f\u5217\u7684\u6574\u5408\uff0c\u8fd9\u4e9b\u56e0\u7d20\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u80fd\u591f\u68c0\u6d4b\u5230\u975e\u5e38\u7f55\u89c1\u7684\u9ad8\u6e17\u900f\u6027\u7b49\u4f4d\u57fa\u56e0\u548c\u643a\u5e26\u5c0f\u98ce\u9669\u589e\u91cf\u7684\u5e38\u89c1\u9057\u4f20\u53d8\u5f02\u3002\u66f4\u4e3a\u91cd\u8981\u7684\u662f\uff0c\u6700\u8fd1\u5728\u7406\u89e3\u8fd9\u4e24\u79cd\u7efc\u5408\u75c7\u65b9\u9762\u53d6\u5f97\u7684\u8fdb\u5c55\uff0c\u4e3a\u6df1\u5165\u63a2\u7a76\u8fd9\u4e9b\u9057\u4f20\u98ce\u9669\u56e0\u7d20\u5728\u5206\u5b50\u3001\u7ec6\u80de\u548c\u795e\u7ecf\u56de\u8def\u5c42\u9762\u5f15\u53d1\u7684\u75c5\u7406\u751f\u7406\u5b66\u5960\u5b9a\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.7.1 \u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\u9057\u4f20\u5b66\u7684\u8fdb\u5c55\u63ed\u793a\u4e86\u7f55\u89c1\u548c\u4ece\u5934\u7a81\u53d8\u5728\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u4e2d\u7684\u5173\u952e\u4f5c\u7528<\/strong><\/p>\n<\/section>\n

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\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u662f\u4e00\u7c7b\u5177\u6709\u4e0d\u540c\u7a0b\u5ea6\u4e25\u91cd\u6027\u7684\u53d1\u80b2\u7efc\u5408\u75c7\uff0c\u5f71\u54cd\u5927\u7ea62%\u81f33%\u7684\u4eba\u53e3\uff0c\u5176\u7279\u5f81\u662f\u793e\u4ea4\u6c9f\u901a\u969c\u788d\u3001\u523b\u677f\u5174\u8da3\u4ee5\u53ca\u91cd\u590d\u884c\u4e3a\u3002ASD\u5728\u7537\u6027\u4e2d\u66f4\u4e3a\u5e38\u89c1\uff0c\u53d7\u5f71\u54cd\u7684\u7537\u5b69\u4eba\u6570\u5e73\u5747\u662f\u5973\u5b69\u7684\u4e09\u500d\u3002ASD\u7684\u4e34\u5e8a\u75c7\u72b6\u901a\u5e38\u5728\u751f\u547d\u7684\u524d3\u5e74\u5185\u663e\u73b0\uff0c\u5c3d\u7ba1\u5728\u751f\u547d\u7684\u6700\u521d\u51e0\u4e2a\u6708\u5185\uff0c\u53d7\u5f71\u54cd\u7684\u513f\u7ae5\u4e0e\u672a\u53d7\u5f71\u54cd\u7684\u513f\u7ae5\u4e4b\u95f4\u5df2\u7ecf\u80fd\u591f\u89c2\u5bdf\u5230\u663e\u8457\u7684\u5dee\u5f02\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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ASD\u60a3\u8005\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u8868\u578b\u53d8\u5f02\u6027\uff0c\u8fd9\u5bfc\u81f4\u4e86\u8be5\u969c\u788d\u7684\u5e7f\u6cdb\u8bca\u65ad\u5206\u7c7b\u3002\u6b64\u5916\uff0cASD\u60a3\u8005\u6bd4\u4e00\u822c\u4eba\u7fa4\u66f4\u9891\u7e41\u5730\u51fa\u73b0\u766b\u75eb\u53d1\u4f5c\u548c\u8ba4\u77e5\u95ee\u9898\uff0c\u5e76\u4e14\u5728\u9002\u5e94\u529f\u80fd\u65b9\u9762\u5f80\u5f80\u9762\u4e34\u4e25\u91cd\u7684\u6311\u6218\u3002\u7136\u800c\uff0c\u8bb8\u591aASD\u60a3\u8005\u5e76\u672a\u53d7\u5230\u5982\u6b64\u4e25\u91cd\u7684\u5f71\u54cd\uff0c\u80fd\u591f\u8fc7\u4e0a\u975e\u5e38\u6210\u529f\u7684\u751f\u6d3b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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ASD\u5177\u6709\u5f88\u5f3a\u7684\u9057\u4f20\u57fa\u7840\uff08\u89c1\u56fe2.1.1A<\/span>\uff09\uff0c\u8fd9\u53ef\u80fd\u662f\u5b83\u6210\u4e3a\u9996\u6279\u901a\u8fc7\u73b0\u4ee3\u57fa\u56e0\u53d1\u73b0\u5de5\u5177\u548c\u65b9\u6cd5\u5f97\u5230\u6df1\u5165\u7814\u7a76\u7684\u590d\u6742\u795e\u7ecf\u7cbe\u795e\u7efc\u5408\u75c7\u4e4b\u4e00\u7684\u539f\u56e0\u3002ASD\u7684\u7814\u7a76\u4e0d\u4ec5\u5bf9\u7406\u89e3\u8fd9\u79cd\u7279\u5b9a\u969c\u788d\u5177\u6709\u610f\u4e49\uff0c\u8fd8\u4e3a\u7406\u89e3\u5178\u578b\u7684\u4eba\u7c7b\u884c\u4e3a\uff08\u5982\u8bed\u8a00\u3001\u590d\u6742\u667a\u529b\u548c\u4eba\u9645\u4e92\u52a8\uff09\u63d0\u4f9b\u4e86\u91cd\u8981\u89c1\u89e3\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cASD\u4e2d\u89c2\u5bdf\u5230\u7684\u793e\u4ea4\u6c9f\u901a\u7f3a\u9677\u53ef\u4ee5\u4e0e\u6b63\u5e38\u667a\u529b\u548c\u5176\u4ed6\u8ba4\u77e5\u529f\u80fd\u5171\u5b58\uff0c\u8fd9\u8868\u660e\u5927\u8111\u5728\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u662f\u6a21\u5757\u5316\u7684\uff0c\u4e0d\u540c\u7684\u8ba4\u77e5\u529f\u80fd\u53ef\u4ee5\u72ec\u7acb\u53d8\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u67d3\u8272\u4f53\u7ed3\u6784\u4e2d\u7684\u4ece\u5934\u4e9a\u663e\u5fae\u7f3a\u5931\u548c\u91cd\u590d\u53ef\u80fd\u663e\u8457\u589e\u52a0\u4e2a\u4f53\u60a3\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\uff08ASD\uff09\u7684\u98ce\u9669\u3002\u8fd9\u4e9b\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNV\uff09\u5f80\u5f80\u96c6\u4e2d\u5728\u57fa\u56e0\u7ec4\u7684\u7279\u5b9a\u533a\u57df\uff0c\u4ece\u800c\u786e\u5b9a\u4e86\u7279\u5b9a\u7684\u98ce\u9669\u533a\u6bb5\u3002\u65e9\u671f\u7684\u7814\u7a76\u8868\u660e\uff0c\u5c3d\u7ba1\u67d3\u8272\u4f5316p11.2\u7684\u65b0\u751fCNV\u4ec5\u51fa\u73b0\u5728\u5927\u7ea60.5%\u81f31%\u7684ASD\u60a3\u8005\u4e2d\uff0c\u4f46\u5b83\u80fd\u5c06\u60a3ASD\u7684\u98ce\u9669\u589e\u52a010\u500d\u4ee5\u4e0a\u3002\u968f\u540e\uff0c\u7814\u7a76\u786e\u5b9a\u4e86\u5341\u591a\u4e2a\u7c7b\u4f3c\u7684\u9ad8\u98ce\u9669CNV\uff0c\u5305\u62ec16\u53f7\u67d3\u8272\u4f531\u533a1\u5e262\u4e9a\u5e26\u30011\u53f7\u67d3\u8272\u4f532\u533a1\u5e26\u300115\u53f7\u67d3\u8272\u4f531\u533a1\u5e261\u4e9a\u5e263\u6b21\u4e9a\u5e26\u30013\u53f7\u67d3\u8272\u4f532\u533a9\u5e26\u300122\u53f7\u67d3\u8272\u4f531\u533a1\u5e26\u548c1\u533a3\u5e26\uff08SHANK3\u57fa\u56e0\u7f3a\u5931\uff09\u30012\u53f7\u67d3\u8272\u4f531\u533a6\u5e26\uff08NXRN1\u57fa\u56e0\u7f3a\u5931\uff09\u4ee5\u53ca7\u53f7\u67d3\u8272\u4f531\u533a1\u5e262\u4e9a\u5e263\u6b21\u4e9a\u5e26\uff08\u5a01\u5ec9\u7efc\u5408\u75c7\u533a\u57df\uff09\u7684\u4ece\u5934\u91cd\u590d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5927\u89c4\u6a21\u7814\u7a76\u73b0\u5df2\u786e\u5b9a\u4e86100\u591a\u4e2a\u4e0eASD\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u5176\u4e2d\u7ea645\u4e2a\u8fbe\u5230\u4e86\u7edf\u8ba1\u5b66\u4e0a\u7684\u6700\u9ad8\u7f6e\u4fe1\u5ea6\u3002\u8fd9\u4e9b\u57fa\u56e0\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684\u5df2\u77e5\u529f\u80fd\uff0c\u4f46\u5206\u6790\u8868\u660e\uff0c\u53c2\u4e0e\u7a81\u89e6\u5f62\u6210\u548c\u529f\u80fd\u4ee5\u53ca\u8f6c\u5f55\u8c03\u63a7\u7684\u57fa\u56e0\u5728ASD\u4e2d\u663e\u8457\u8fc7\u91cf\u3002\u6b64\u5916\uff0c\u7f16\u7801\u8106\u6027X\u667a\u529b\u4f4e\u4e0b\u86cb\u767d\u7684\u57fa\u56e0\u4ee5\u53ca\u5728\u65e9\u671f\u5927\u8111\u53d1\u80b2\u4e2d\u6d3b\u8dc3\u7684\u57fa\u56e0\u4e5f\u663e\u8457\u8d85\u8fc7\u4e86\u9884\u671f\u3002\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u7406\u89e3ASD\u7684\u751f\u7269\u5b66\u57fa\u7840\u63d0\u4f9b\u4e86\u91cd\u8981\u7ebf\u7d22\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.7.2 \u7cbe\u795e\u5206\u88c2\u75c7\u57fa\u56e0\u7684\u9274\u5b9a\u63ed\u793a\u4e86\u7f55\u89c1\u548c\u5e38\u89c1\u98ce\u9669\u53d8\u5f02\u7684\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n<\/section>\n

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\u7cbe\u795e\u5206\u88c2\u75c7\u5f71\u54cd\u4e86\u7ea61%\u7684\u5e74\u8f7b\u4eba\uff0c\u8868\u73b0\u4e3a\u601d\u7ef4\u969c\u788d\u548c\u60c5\u611f\u9000\u7f29\uff0c\u4e25\u91cd\u635f\u5bb3\u4e86\u751f\u6d3b\u8d28\u91cf\u3002\u8fd9\u79cd\u75be\u75c5\u5177\u6709\u5f88\u5f3a\u7684\u9057\u4f20\u6027\uff08\u89c1\u56fe2.1.1B<\/span>\uff09\uff0c\u540c\u65f6\u4e5f\u53d7\u5230\u4e0e\u80ce\u513f\u671f\u538b\u529b\u76f8\u5173\u7684\u5f3a\u5927\u73af\u5883\u56e0\u7d20\u7684\u5f71\u54cd\u3002\u4e8c\u6218\u540e\u8377\u5170\u9965\u8352\u671f\u95f4\u51fa\u751f\u7684\u513f\u7ae5\uff0c\u5728\u591a\u5e74\u540e\u60a3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u98ce\u9669\u663e\u8457\u589e\u52a0\uff1b\u540c\u6837\uff0c\u57281960\u5e74\u4ee3\u98ce\u75b9\u75c5\u6bd2\u5927\u6d41\u884c\u671f\u95f4\uff0c\u5b55\u671f\u611f\u67d3\u98ce\u75b9\u75c5\u6bd2\u7684\u6bcd\u4eb2\u6240\u751f\u7684\u513f\u7ae5\uff0c\u4e5f\u9762\u4e34\u66f4\u9ad8\u7684\u60a3\u75c5\u98ce\u9669\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u53d1\u75c5\u53d7\u57fa\u56e0\u548c\u73af\u5883\u7684\u5171\u540c\u5f71\u54cd\u3002\u4e0e\u5b64\u72ec\u75c7\u7c7b\u4f3c\uff0c\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u3001\u5168\u57fa\u56e0\u7ec4\u57fa\u56e0\u5206\u578b\u548c\u62f7\u8d1d\u6570\u53d8\u5f02\uff08CNV\uff09\u68c0\u6d4b\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u52a0\u4e0a\u5927\u89c4\u6a21\u60a3\u8005\u961f\u5217\u7684\u6574\u5408\uff0c\u63a8\u52a8\u4e86\u7cbe\u795e\u5206\u88c2\u75c7\u9057\u4f20\u5b66\u7814\u7a76\u7684\u91cd\u5927\u7a81\u7834\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9996\u5148\uff0c\u52302000\u5e74\u4ee3\u521d\u671f\uff0c\u7f55\u89c1\u7684\u65b0\u53d1CNV\u5f00\u59cb\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u98ce\u9669\u76f8\u5173\u8054\u3002\u8fd9\u4e9b\u67d3\u8272\u4f53\u5f02\u5e38\u5f80\u5f80\u4e0e\u81ea\u95ed\u75c7\u8c31\u7cfb\u969c\u788d\u76f8\u5173\u7684\u4f4d\u70b9\u9ad8\u5ea6\u91cd\u53e0\uff0c\u4f46\u5728\u98ce\u9669\u8868\u73b0\u4e0a\u6709\u6240\u4e0d\u540c\u3002\u4f8b\u5982\uff0c16\u53f7\u67d3\u8272\u4f531\u533a1\u5e262\u4e9a\u5e26\u533a\u57df\u7684\u91cd\u590d\u548c\u7f3a\u5931\u90fd\u4e0eASD\u548c\u7cbe\u795e\u5206\u88c2\u75c7\u6709\u5173\uff0c\u4f46\u8be5\u533a\u57df\u7684\u91cd\u590d\u66f4\u53ef\u80fd\u5bfc\u81f4\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u800c\u7f3a\u5931\u5219\u66f4\u5e38\u89c1\u4e8eASD\u548c\u667a\u529b\u969c\u788d\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fc7\u53bb\u5341\u4e94\u5e74\u4e2d\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7814\u7a76\u7684\u6700\u91cd\u8981\u8fdb\u5c55\u4e4b\u4e00\u662f\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u7684\u51fa\u73b0\u3002\u4e0e\u65e9\u671f\u57fa\u4e8e\u5047\u8bbe\u7684\u5019\u9009\u57fa\u56e0\u7814\u7a76\u4e0d\u540c\uff0cGWAS\u901a\u8fc7\u540c\u65f6\u68c0\u6d4b\u57fa\u56e0\u7ec4\u4e2d\u6bcf\u4e2a\u57fa\u56e0\u7684\u591a\u6001\u6027\u6765\u8bc6\u522b\u98ce\u9669\u57fa\u56e0\u3002\u8fd9\u79cd\u65e0\u5047\u8bbe\u7684\u65b9\u6cd5\uff0c\u7ed3\u5408\u5927\u89c4\u6a21\u961f\u5217\uff0c\u5e76\u9002\u5f53\u6821\u6b63\u591a\u91cd\u6bd4\u8f83\uff0c\u5df2\u6210\u4e3a\u4e00\u79cd\u9ad8\u5ea6\u53ef\u9760\u548c\u53ef\u91cd\u590d\u7684\u7b56\u7565\uff0c\u7528\u4e8e\u8bc6\u522b\u5e38\u89c1\u75be\u75c5\u4e2d\u7684\u5e38\u89c1\u98ce\u9669\u7b49\u4f4d\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e00\u53d1\u73b0\u662f\u5c06\u57fa\u56e0\u7ec4\u5b66\u4e0e\u75be\u75c5\u98ce\u9669\u7684\u6f5c\u5728\u751f\u7269\u673a\u5236\u8054\u7cfb\u8d77\u6765\u7684\u4e00\u4e2a\u91cd\u8981\u4f8b\u8bc1\u3002\u7136\u800c\uff0c\u5373\u4f7f\u643a\u5e26\u6700\u9ad8\u98ce\u9669C4\u5355\u500d\u578b\u4e14\u6ca1\u6709\u7cbe\u795e\u5206\u88c2\u75c7\u5bb6\u65cf\u53f2\u7684\u4e2a\u4f53\uff0c\u5176\u56e0\u8be5\u7b49\u4f4d\u57fa\u56e0\u800c\u7f79\u60a3\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u6982\u7387\u4e5f\u4ec5\u4ece1%\u589e\u52a0\u5230\u7ea61.3%\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u6709\u4e00\u7ea7\u4eb2\u5c5e\u60a3\u6709\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u4e2a\u4f53\uff0c\u5176\u98ce\u9669\u589e\u52a0\u7ea610\u500d\u3002\u8fd9\u4e00\u53d1\u73b0\u663e\u793a\u4e86\u7cbe\u795e\u5206\u88c2\u75c7\u9057\u4f20\u7814\u7a76\u7684\u5e0c\u671b\uff0c\u540c\u65f6\u4e5f\u63ed\u793a\u4e86\u5176\u5c40\u9650\u6027\uff1a\u4ece\u5e38\u89c1\u53d8\u5f02\u7684\u6210\u529f\u9274\u5b9a\u5230\u6df1\u5165\u89e3\u6790\u5bfc\u81f4\u4eba\u7c7b\u75c5\u7406\u7684\u5177\u4f53\u673a\u5236\u4e4b\u95f4\u4ecd\u7136\u5b58\u5728\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86\u786e\u5b9a\u591a\u4e2a\u7279\u5b9a\u7684\u98ce\u9669\u4f4d\u70b9\u5916\uff0cGWAS\u7814\u7a76\u8fd8\u53d1\u73b0\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u98ce\u9669\u662f\u7531\u8bb8\u591a\u5e38\u89c1\u7b49\u4f4d\u57fa\u56e0\u7684\u7d2f\u52a0\u6548\u5e94\u63a8\u52a8\u7684\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e3a\u63a2\u7d22\u57fa\u56e0\u578b\u4e0e\u8868\u578b\u5173\u7cfb\u63d0\u4f9b\u4e86\u65b0\u7684\u5f3a\u5927\u8def\u5f84\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e2a\u4f53\u643a\u5e26\u7684\u98ce\u9669\u7b49\u4f4d\u57fa\u56e0\u6570\u91cf\u4f1a\u663e\u8457\u5f71\u54cd\u5176\u60a3\u75c5\u98ce\u9669\u3002\u4f8b\u5982\uff0c\u5728\u6240\u8c13\u7684\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\u4e2d\u5904\u4e8e\u6700\u9ad8\u5341\u5206\u4f4d\u6570\u7684\u4eba\uff0c\u5176\u7cbe\u795e\u5206\u88c2\u75c7\u98ce\u9669\u6bd4\u666e\u901a\u4eba\u7fa4\u9ad8\u51fa8\u523020\u500d\u3002\u867d\u7136\u7d2f\u79ef\u6548\u5e94\u7684\u751f\u7269\u5b66\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u4f46\u8fd9\u4e00\u53d1\u73b0\u4e3a\u7814\u7a76\u4e0e\u75be\u75c5\u8fdb\u7a0b\u548c\u6cbb\u7597\u53cd\u5e94\u76f8\u5173\u7684\u95ee\u9898\u5960\u5b9a\u4e86\u57fa\u7840\uff0c\u5e76\u53ef\u80fd\u91cd\u65b0\u6fc0\u53d1\u7ed3\u5408\u795e\u7ecf\u5f71\u50cf\u5b66\u4e0e\u57fa\u56e0\u7ec4\u5b66\u7684\u7814\u7a76\u5174\u8da3\u3002\u65e9\u671f\u7684\u5e38\u89c1\u53d8\u5f02\u7814\u7a76\u66fe\u56e0\u4e13\u6ce8\u4e8e\u751f\u7269\u5b66\u4e0a\u5408\u7406\u7684\u5019\u9009\u57fa\u56e0\u800c\u5b58\u5728\u5c40\u9650\u6027\uff0c\u5bfc\u81f4\u7ed3\u679c\u7684\u53ef\u9760\u6027\u95ee\u9898\uff0c\u800c\u65b0\u7684\u65b9\u6cd5\u6709\u671b\u6539\u5584\u8fd9\u4e00\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u7c7b\u4f3c\u4e8e\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\u7814\u7a76\u4e2d\u91c7\u7528\u7684\u9ad8\u901a\u91cf\u6d4b\u5e8f\u65b9\u6cd5\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7814\u7a76\u4e2d\u4e5f\u5f00\u59cb\u5e94\u7528\u8fd9\u4e9b\u6280\u672f\u5e76\u53d6\u5f97\u4e86\u521d\u6b65\u6210\u679c\u3002\u5177\u4f53\u6765\u8bf4\uff0c\u5916\u663e\u5b50\u7ec4\u6d4b\u5e8f\u5728\u5bfb\u627e\u7f55\u89c1\u548c\u65b0\u53d1\u98ce\u9669\u7b49\u4f4d\u57fa\u56e0\u65b9\u9762\u53d6\u5f97\u4e86\u4e00\u4e9b\u6210\u529f\u3002\u7136\u800c\uff0c\u4e0e\u5b64\u72ec\u75c7\u8c31\u7cfb\u969c\u788d\u76f8\u6bd4\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u7814\u7a76\u9700\u8981\u66f4\u5927\u7684\u961f\u5217\u6765\u786e\u5b9a\u53ef\u80fd\u7684\u57fa\u56e0\u7834\u574f\u7a81\u53d8\u7684\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff0c\u8fd9\u8868\u660e\u8fd9\u4e9b\u53d8\u5f02\u5728\u7cbe\u795e\u5206\u88c2\u75c7\u4e2d\u7684\u6574\u4f53\u5f71\u54cd\u53ef\u80fd\u8f83\u5c0f\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8fd9\u4e9b\u7814\u7a76\u5df2\u7ecf\u9274\u5b9a\u51fa\u4e00\u4e9b\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u98ce\u9669\u57fa\u56e0\uff0c\u5e76\u6d89\u53ca\u5173\u952e\u7684\u795e\u7ecf\u751f\u7269\u5b66\u9014\u5f84\u3002\u7279\u522b\u662f\uff0c\u6700\u8fd1\u7684\u5916\u663e\u5b50\u7ec4\u7814\u7a76\u63ed\u793a\u4e86\u6d3b\u6027\u8c03\u8282\u7684\u7ec6\u80de\u9aa8\u67b6\u590d\u5408\u4f53\u4e2d\u7684\u5206\u5b50\uff0c\u4ee5\u53ca\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u53d1\u75c5\u673a\u5236\u76f8\u5173\u7684\u7ec4\u86cb\u767dH3\u8d56\u6c28\u91784\u7279\u5f02\u6027\u7532\u57fa\u8f6c\u79fb\u9176\u76f8\u5173\u7684\u57fa\u56e0\u7ec4\u7ed3\u6784\u57df\u7684\u91cd\u8981\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.8 \u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u9057\u4f20\u57fa\u7840\u7684\u89c1\u89e3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u57fa\u56e0\u5728\u884c\u4e3a\u7684\u8bb8\u591a\u65b9\u9762\u90fd\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5373\u4f7f\u662f\u5206\u5f00\u629a\u517b\u7684\u53cc\u80de\u80ce\uff0c\u4e5f\u5728\u6027\u683c\u7279\u8d28\u548c\u7cbe\u795e\u75be\u75c5\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u7684\u76f8\u4f3c\u6027\u3002\u5bb6\u755c\u548c\u5b9e\u9a8c\u5ba4\u52a8\u7269\u53ef\u4ee5\u901a\u8fc7\u57f9\u80b2\u5c55\u73b0\u51fa\u7279\u5b9a\u7684\u3001\u7a33\u5b9a\u7684\u884c\u4e3a\u7279\u5f81\uff1b\u6b64\u5916\uff0c\u6211\u4eec\u5bf9\u795e\u7ecf\u53d1\u80b2\u548c\u7cbe\u795e\u75be\u75c5\u7684\u5e7f\u6cdb\u9057\u4f20\u53d8\u5f02\u7684\u8d21\u732e\u4e5f\u5728\u4e0d\u65ad\u52a0\u6df1\u7406\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e00\u7cfb\u5217\u5e73\u884c\u7684\u53d1\u5c55\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4e00\u4e2a\u524d\u6240\u672a\u6709\u7684\u673a\u4f1a\u53bb\u7406\u89e3\u57fa\u56e0\u3001\u5927\u8111\u548c\u884c\u4e3a\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u7528\u4e8e\u64cd\u4f5c\u548c\u7814\u7a76\u6a21\u578b\u7cfb\u7edf\u7684\u6280\u672f\u5df2\u7ecf\u53d1\u751f\u4e86\u9769\u547d\u6027\u7684\u53d8\u5316\uff1b\u4e0e\u6b64\u540c\u65f6\uff0c\u5728\u786e\u5b9a\u4eba\u7c7b\u795e\u7ecf\u7cbe\u795e\u75be\u75c5\u7684\u9057\u4f20\u98ce\u9669\u56e0\u7d20\u65b9\u9762\u4e5f\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\u3002\u5c3d\u7ba1\u8fd9\u4e2a\u9886\u57df\u4ecd\u5904\u4e8e\u53d1\u5c55\u7684\u65e9\u671f\u9636\u6bb5\uff0c\u4f46\u5df2\u7ecf\u6709\u4e86\u591a\u4e2a\u6210\u529f\u7684\u57fa\u56e0\u53d1\u73b0\u6848\u4f8b\uff0c\u5e76\u901a\u8fc7\u8fd9\u4e9b\u53d1\u73b0\u8fdb\u4e00\u6b65\u6df1\u5316\u4e86\u5bf9\u76f8\u5173\u751f\u7269\u5b66\u7684\u7406\u89e3\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6700\u8fd1\u795e\u7ecf\u53d1\u80b2\u548c\u7cbe\u795e\u75be\u75c5\u9057\u4f20\u5b66\u7814\u7a76\u4e2d\u7684\u4e00\u4e2a\u5f15\u4eba\u6ce8\u76ee\u7684\u53d1\u73b0\u662f\uff0c\u4e0d\u540c\u8bca\u65ad\u8303\u7574\u4e4b\u95f4\u7684\u9057\u4f20\u98ce\u9669\u5b58\u5728\u91cd\u53e0\u3002\u5c3d\u7ba1\u751f\u7269\u5b66\u4e0d\u5b8c\u5168\u9075\u5faa\u4f20\u7edf\u7684\u5206\u7c7b\u8bca\u65ad\u6807\u51c6\u8fd9\u4e00\u70b9\u5e76\u4e0d\u4ee4\u4eba\u610f\u5916\uff0c\u4f46\u5982\u4f55\u8ffd\u8e2a\u8fd9\u4e9b\u91cd\u53e0\u6548\u5e94\u5e76\u63d0\u51fa\u65b0\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u4ecd\u7136\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u5bf9\u4e8e\u8bb8\u591a\u5c1a\u672a\u53d6\u5f97\u663e\u8457\u8fdb\u5c55\u7684\u7cbe\u795e\u75be\u75c5\uff0c\u89e3\u51b3\u65b9\u6848\u4f3c\u4e4e\u4e5f\u5f88\u7b80\u5355\uff1a\u66f4\u5927\u7684\u6295\u8d44\u548c\u66f4\u5927\u7684\u6837\u672c\u91cf\u5c06\u5e26\u6765\u66f4\u6df1\u5165\u7684\u6d1e\u5bdf\u529b\u3002\u4f8b\u5982\uff0c\u6700\u8fd1\u5bf9\u56fe\u96f7\u7279\u7efc\u5408\u75c7\u548c\u5f3a\u8feb\u75c7\u65b0\u53d1\u7a81\u53d8\u7684\u7814\u7a76\u8868\u660e\uff0c\u9650\u5236\u9ad8\u7f6e\u4fe1\u5ea6\u98ce\u9669\u57fa\u56e0\u9274\u5b9a\u7684\u5173\u952e\u56e0\u7d20\u662f\u4eb2\u5b50\u4e09\u4eba\u7ec4\u6d4b\u5e8f\u6570\u636e\u7684\u53ef\u7528\u6027\u3002\u540c\u6837\uff0c\u91cd\u5ea6\u6291\u90c1\u75c7\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff0c\u76f4\u5230\u6700\u8fd1\u6837\u672c\u91cf\u624d\u8fbe\u5230\u8db3\u4ee5\u786e\u8ba4\u7edf\u8ba1\u5b66\u663e\u8457\u76f8\u5173\u53d8\u5f02\u7684\u6c34\u5e73\u3002\u8fd9\u4e9b\u7814\u7a76\u5305\u62ec\u4e86\u6570\u5341\u4e07\u4eba\uff0c\u5e76\u4e14\u4e0d\u51fa\u6240\u6599\u5730\u53d1\u73b0\u4e86\u5bf9\u75be\u75c5\u98ce\u9669\u4ec5\u6709\u5fae\u5c0f\u5f71\u54cd\u7684\u7b49\u4f4d\u57fa\u56e0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd9\u4e00\u70b9\u7a81\u51fa\u4e86\u4e00\u4e2a\u91cd\u8981\u89c2\u70b9\uff0c\u5373\u5728\u884c\u4e3a\u3001\u53d1\u80b2\u548c\u7cbe\u795e\u75be\u75c5\u7684\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\u4e2d\uff0c\u6ca1\u6709\u4e00\u79cd\u65b9\u6cd5\u80fd\u9002\u7528\u4e8e\u6240\u6709\u60c5\u51b5\u3002\u4ece\u6a21\u578b\u7cfb\u7edf\u7684\u7814\u7a76\u5230\u7f55\u89c1\u5b5f\u5fb7\u5c14\u75be\u75c5\u7684\u89e3\u6790\uff0c\u518d\u5230\u5e38\u89c1\u548c\u7f55\u89c1\u53d8\u5f02\u5bf9\u5e38\u89c1\u75be\u75c5\u7684\u8d21\u732e\uff0c\u5f53\u4eca\u53ef\u7528\u7684\u5de5\u5177\u548c\u7814\u7a76\u673a\u4f1a\u662f\u524d\u6240\u672a\u6709\u7684\u3002\u672a\u6765\u51e0\u5e74\u5e94\u8be5\u80fd\u591f\u5927\u5e45\u52a0\u6df1\u6211\u4eec\u5bf9\u7cbe\u795e\u75be\u75c5\u548c\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u7684\u751f\u7269\u5b66\u7406\u89e3\uff0c\u5e76\u6709\u671b\u5e26\u6765\u53ef\u4ee5\u5e2e\u52a9\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.9 \u672c\u7ae0\u8981\u70b9\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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1. \u8106\u6027X\u7efc\u5408\u75c7\u3001\u96f7\u7279\u7efc\u5408\u75c7\u548c\u5a01\u5ec9\u7efc\u5408\u75c7\u7b49\u7f55\u89c1\u9057\u4f20\u7efc\u5408\u75c7\u4e3a\u6211\u4eec\u63ed\u793a\u4e86\u590d\u6742\u4eba\u7c7b\u884c\u4e3a\u7684\u5206\u5b50\u673a\u5236\uff0c\u63d0\u4f9b\u4e86\u5b9d\u8d35\u7684\u89c1\u89e3\u3002\u5c3d\u7ba1\u76f8\u5173\u7814\u7a76\u4ecd\u6709\u5927\u91cf\u5de5\u4f5c\u8981\u5b8c\u6210\uff0c\u4f46\u8fd9\u4e9b\u7814\u7a76\u5df2\u7ecf\u6311\u6218\u4e86\u8ba4\u77e5\u548c\u884c\u4e3a\u7f3a\u9677\u4e0d\u53ef\u6539\u53d8\u7684\u89c2\u5ff5\uff0c\u5e76\u8bc1\u660e\u4e86\u5e7f\u6cdb\u5e94\u7528\u6a21\u578b\u7cfb\u7edf\u5728\u9610\u660e\u4fdd\u5b88\u751f\u7269\u5b66\u673a\u5236\u65b9\u9762\u7684\u6548\u7528\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2. \u968f\u7740\u4eba\u7c7b\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u3001\u9ad8\u901a\u91cf\u57fa\u56e0\u7ec4\u68c0\u6d4b\u7684\u53d1\u5c55\uff0c\u4ee5\u53ca\u8ba1\u7b97\u548c\u65b9\u6cd5\u5b66\u7684\u8fdb\u6b65\uff0c\u6211\u4eec\u5bf9\u4eba\u7c7b\u884c\u4e3a\u548c\u7cbe\u795e\u75be\u75c5\u9057\u4f20\u5b66\u7684\u7406\u89e3\u53d1\u751f\u4e86\u6df1\u523b\u53d8\u9769\u3002\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u81ea\u95ed\u75c7\u7b49\u51e0\u79cd\u5178\u578b\u75be\u75c5\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u663e\u8457\u8fdb\u5c55\uff0c\u5df2\u9274\u5b9a\u51fa\u6570\u5341\u4e2a\u660e\u786e\u7684\u9057\u4f20\u98ce\u9669\u57fa\u56e0\u548c\u67d3\u8272\u4f53\u533a\u57df\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3. \u8fc7\u53bb\u5341\u5e74\u91cc\uff0c\u7cbe\u795e\u75c5\u5b66\u9057\u4f20\u5b66\u548c\u57fa\u56e0\u7ec4\u5b66\u9886\u57df\u7684\u53d1\u5c55\u63ed\u793a\u4e86\u4f20\u7edf\u5019\u9009\u57fa\u56e0\u7814\u7a76\u7684\u5c40\u9650\u6027\u3002\u8fd9\u7c7b\u7814\u7a76\u73b0\u5df2\u88ab\u5168\u57fa\u56e0\u7ec4\u626b\u63cf\u53d6\u4ee3\uff0c\u6db5\u76d6\u4e86\u5e38\u89c1\u548c\u7f55\u89c1\u7b49\u4f4d\u57fa\u56e0\u3002\u901a\u8fc7\u7ed3\u5408\u4e25\u683c\u7684\u7edf\u8ba1\u6846\u67b6\u548c\u5171\u8bc6\u7edf\u8ba1\u9608\u503c\uff0c\u8fd9\u4e9b\u7814\u7a76\u6b63\u5728\u4ea7\u751f\u9ad8\u5ea6\u53ef\u9760\u4e14\u53ef\u91cd\u590d\u7684\u7ed3\u679c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4. \u76ee\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u590d\u6742\u884c\u4e3a\u7efc\u5408\u75c7\u7684\u9057\u4f20\u57fa\u7840\u6db5\u76d6\u4e86\u591a\u79cd\u7c7b\u578b\u7684\u53d8\u5f02\uff0c\u5305\u62ec\u5e38\u89c1\u548c\u7f55\u89c1\u3001\u9057\u4f20\u548c\u65b0\u53d1\u3001\u751f\u6b96\u7ec6\u80de\u548c\u4f53\u7ec6\u80de\uff0c\u4ee5\u53ca\u5e8f\u5217\u548c\u67d3\u8272\u4f53\u7ed3\u6784\u53d8\u5f02\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u4e0d\u540c\u7c7b\u578b\u7684\u9057\u4f20\u53d8\u5f02\u5bf9\u7279\u5b9a\u75be\u75c5\u7684\u5f71\u54cd\u7a0b\u5ea6\u5404\u4e0d\u76f8\u540c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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5. \u4eba\u7c7b\u884c\u4e3a\u9057\u4f20\u5b66\u7684\u6700\u65b0\u53d1\u73b0\u4e2d\u4e00\u4e2a\u5f15\u4eba\u6ce8\u76ee\u7684\u73b0\u8c61\u662f\uff0c\u5177\u6709\u4e0d\u540c\u75c7\u72b6\u548c\u75c5\u7a0b\u7684\u7efc\u5408\u75c7\u4e4b\u95f4\u5b58\u5728\u9057\u4f20\u98ce\u9669\u7684\u91cd\u53e0\u3002\u7406\u89e3\u76f8\u540c\u7a81\u53d8\u5982\u4f55\u5728\u4e0d\u540c\u4e2a\u4f53\u4e2d\u5bfc\u81f4\u591a\u6837\u5316\u7684\u8868\u578b\u7ed3\u679c\uff0c\u5c06\u662f\u672a\u6765\u7814\u7a76\u4e2d\u7684\u4e00\u5927\u6311\u6218\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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6. \u5e38\u89c1\u7cbe\u795e\u75be\u75c5\u7684\u7814\u7a76\u8868\u660e\uff0c\u9057\u4f20\u5f02\u8d28\u6027\u975e\u5e38\u9ad8\u3002\u8fd9\u4e00\u73b0\u8c61\uff0c\u52a0\u4e0a\u5df2\u786e\u5b9a\u7684\u98ce\u9669\u57fa\u56e0\u7684\u751f\u7269\u5b66\u591a\u6548\u6027\uff0c\u4ee5\u53ca\u4eba\u7c7b\u5927\u8111\u53d1\u80b2\u7684\u52a8\u6001\u6027\u548c\u590d\u6742\u6027\uff0c\u9884\u793a\u7740\u5728\u4ece\u7406\u89e3\u98ce\u9669\u57fa\u56e0\u5230\u7406\u89e3\u884c\u4e3a\u4e4b\u95f4\u5b58\u5728\u91cd\u5927\u6311\u6218\u3002\u540c\u6837\uff0c\u76ee\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u63ed\u793a\u98ce\u9669\u57fa\u56e0\u7684\u751f\u7269\u5b66\u529f\u80fd\u4e0e\u9610\u660e\u884c\u4e3a\u7efc\u5408\u75c7\u7684\u75c5\u7406\u751f\u7406\u5b66\u4e4b\u95f4\u8fd8\u5b58\u5728\u91cd\u8981\u7684\u533a\u522b\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672c\u6587\u7ffb\u8bd1\u6574\u7406\u81eaPrinciples of Neural Science, Sixth Edition\uff0c\u7ffb\u8bd1\u521d\u7a3f\u6765\u81ea\u4e8eGitHub\/OpenHUTB\uff0c\u672c\u516c\u4f17\u53f7\u8fdb\u884c\u8fdb\u4e00\u6b65\u6821\u5bf9\u6392\u7248\u540e\u53d1\u5e03\uff0c\u4ec5\u7528\u4e8e\u5b66\u4e60\u4ea4\u6d41\u4f7f\u7528\uff0c\u5982\u9700\u8d2d\u4e70\u539f\u7248\u4e66\u7c4d\u53ef\u70b9\u51fb\u9605\u8bfb\u539f\u6587\u8d2d\u4e70\u3002<\/span>
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\u2014 THE  END \u2014<\/span><\/p>\n


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\u6765\u6e90 | Principles of Neural Science, Sixth Edition<\/span><\/p>\n

\u56fe\u6587\u6392\u7248 | \u674e\u828b\u5cad<\/span><\/span><\/p>\n

\u5ba1\u6838\u4fee\u6539 | \u738b\u5764<\/span><\/p>\n

\uff08\u8f6c\u8f7d\u8bf7\u4fdd\u7559\u6b64\u90e8\u5206\u5185\u5bb9\uff09<\/span><\/strong><\/p>\n

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\u80bf\u7624\u514d\u75ab\u5b66\u6700\u65b0\u6587\u732e<\/span><\/a>
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\u53ef\u4ee5\u67e5\u8be22024\u5e74\u6700\u65b0SCI\u671f\u520a\u5f71\u54cd\u56e0\u5b50\u53ca\u5206\u533a\u5566\uff01<\/span><\/a>
\u514d\u75ab\u5b66\u62fe\u9057\u7cfb\u5217<\/span><\/a><\/p>\n

\u80bf\u7624\u514d\u75ab\u5b66\u7cfb\u5217<\/span><\/a><\/p>\n

\u795e\u7ecf\u79d1\u5b66\u539f\u7406\u7cfb\u5217<\/span><\/a><\/p>\n

ACIR\u6587\u732e\u901f\u9012<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u4f5c\u56fe<\/span><\/a><\/p>\n

SCI\u8bba\u6587\u5199\u4f5c\u53ca\u6295\u7a3f<\/span><\/a><\/p>\n

\u751f\u4fe1\u5165\u95e8\u5b66\u4e60\u7b14\u8bb0<\/span><\/a><\/p>\n

R\u8bed\u8a00\u57fa\u7840\u4e0e\u5355\u7ec6\u80de\u5206\u6790\u5b9e\u6218\u89c6\u9891\u8bfe\u7a0b<\/span><\/a><\/p>\n

\u751f\u7269\u5b66\u5b9e\u9a8c\u6280\u672f\u53ca\u5e38\u7528\u8f6f\u4ef6<\/span><\/a><\/p>\n

\u5e38\u7528\u5b9e\u9a8c<\/span>\u4eea\u5668\u7b80\u4ecb\u53ca\u64cd\u4f5c\u89c6\u9891<\/span><\/a><\/span><\/p>\n

\u5e38\u7528\u7535\u8111\u8f6f\u4ef6\u4f7f\u7528\u6559\u7a0b<\/span><\/a><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u5173\u6ce8\u672c\u53f7~<\/span>
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\u52a0\u5165\u8bfb\u8005\u4ea4\u6d41\u7fa4~<\/span><\/p>\n

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\u52a0\u5165\u77e5\u8bc6\u661f\u7403~<\/span><\/p>\n


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\u70b9\u4eae\u8d5e\u4e0e\u5728\u770b <\/span><\/p>\n

\u8ba9\u66f4\u591a\u4eba\u770b\u5230<\/span><\/p>\n

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\u672c\u7bc7\u6587\u7ae0\u6765\u6e90\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7: OncoLab <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u4e0a\u671f\u5185\u5bb9\uff1a\u795e\u7ecf\u79d1\u5b66\u539f\u7406-\u7b2c2\u7ae0 \u57fa\u56e0\u548c\u884c\u4e3a\uff08\u4e0a\uff09 2.6 \u901a\u8fc7\u7814\u7a76\u4eba\u7c7b\u9057\u4f20\u7efc\u5408\u75c7\u521d\u6b65\u63ed\u793a\u793e\u4f1a\u884c\u4e3a\u7684\u57fa\u7840 2.6…<\/p>\n","protected":false},"author":1,"featured_media":3708,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[78],"tags":[],"_links":{"self":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3709"}],"collection":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/comments?post=3709"}],"version-history":[{"count":0,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/posts\/3709\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media\/3708"}],"wp:attachment":[{"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/media?parent=3709"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/categories?post=3709"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/oncolab.cn\/index.php\/wp-json\/wp\/v2\/tags?post=3709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}